Genes encoding longevity: from model organisms to humans.
paper
Cited
Public
Unavailable
- Authors
- Kuningas, Maris; Mooijaart, Simon P; van Heemst, Diana; Zwaan, Bas J; Slagboom, P Eline; Westendorp, Rudi G J
- Year
- 2008
- Journal
- Aging cell
- PMID
- 18208581
- DOI
- 10.1111/j.1474-9726.2008.00366.x
Ample evidence from model organisms has indicated that subtle variation in genes can dramatically influence lifespan. The key genes and molecular pathways that have been identified so far encode for metabolism, maintenance and repair mechanisms that minimize age-related accumulation of permanent damage. Here, we describe the evolutionary conserved genes that are involved in lifespan regulation of model organisms and humans, and explore the reasons of discrepancies that exist between the results found in the various species. In general, the accumulated data have revealed that when moving up the evolutionary ladder, together with an increase of genome complexity, the impact of candidate genes on lifespan becomes smaller. The presence of genetic networks makes it more likely to expect impact of variation in several interacting genes to affect lifespan in humans. Extrapolation of findings from experimental models to humans is further complicated as phenotypes are critically dependent on the setting in which genes are expressed, while laboratory conditions and modern environments are markedly dissimilar. Finally, currently used methodologies may have only little power and validity to reveal genetic variation in the population. In conclusion, although the study of model organisms has revealed potential candidate genetic mechanisms determining aging and lifespan, to what extent they explain variation in human populations is still uncertain.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Longevity candidate genes and their association with personality traits in the elderly. | 2012 | 22213687 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Design principles of gene circuits for longevity. | Godoy P et al. | β | 2025 | β |
| Rationale and design of the Dog Aging Project precision cohort: a multi-omic resource for longitudinal research in geroscience. | Prescott J et al. | β | 2025 | β |
| Enhanced cellular longevity arising from environmental fluctuations. | Liu Y et al. | β | 2024 | β |
| Senolytics Enhance the Longevity of Caenorhabditis elegans by Altering Betaine Metabolism. | Lan W et al. | β | 2024 | β |
| Dietary stress remodels the genetic architecture of lifespan variation in outbred Drosophila. | Pallares LF et al. | β | 2023 | β |
| Engineering longevity-design of a synthetic gene oscillator to slow cellular aging. | Zhou Z et al. | β | 2023 | β |
| Senolytics enhance longevity in<i>Caenorhabditis elegans</i>by altering betaine metabolism | Lan W et al. | β | 2023 | β |
| Sex- and APOE-specific genetic risk factors for late-onset Alzheimer's disease: Evidence from gene-gene interaction of longevity-related loci. | Dato S et al. | β | 2023 | β |
| Association Between a Novel Metabolic Score for Insulin Resistance and Mortality in People With Diabetes. | Wang Z et al. | β | 2022 | β |
| MTBP and MYC: A Dynamic Duo in Proliferation, Cancer, and Aging. | Grieb BC et al. | β | 2022 | β |
| The Nonlinear Correlation Between a Novel Metabolic Score for Insulin Resistance and Subclinical Myocardial Injury in the General Population. | Wang Z et al. | β | 2022 | β |
| Gene-by-environment modulation of lifespan and weight gain in the murine BXD family. | Roy S et al. | β | 2021 | β |
| Hippocampal epigenetic and insulin-like growth factor alterations in noninvasive versus invasive mechanical ventilation in preterm lambs. | Ke X et al. | β | 2021 | β |
| An Aging-Related Single-Nucleotide Polymorphism is Associated With Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients. | Lamparello AJ et al. | β | 2020 | β |
| A scan for genes associated with cancer mortality and longevity in pedigree dog breeds. | Doherty A et al. | β | 2020 | β |
| Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. | Florian MC et al. | β | 2020 | β |
| Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy. | Li YF et al. | β | 2018 | β |
| Mechanisms involved in anti-aging effects of guarana (Paullinia cupana) in Caenorhabditis elegans. | Arantes LP et al. | β | 2018 | β |
| Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease. | Santos AL et al. | β | 2017 | β |
| Sevoflurane downregulates IGFβ1 via microRNAβ98. | Jiang J et al. | β | 2017 | β |
| Functionally Diverse NK-Like T Cells Are Effectors and Predictors of Successful Aging. | Michel JJ et al. | β | 2016 | β |
| Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice. | Grieb BC et al. | β | 2016 | β |
| Has gene duplication impacted the evolution of Eutherian longevity? | Doherty A et al. | β | 2016 | β |
| Physiological underpinnings in life-history trade-offs in man's most popular selection experiment: the dog. | Jimenez AG | β | 2016 | β |
| Rosmarinus officinalis L. increases Caenorhabditis elegans stress resistance and longevity in a DAF-16, HSF-1 and SKN-1-dependent manner. | Zamberlan DC et al. | β | 2016 | β |
| Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies. | Kulminski AM et al. | β | 2015 | β |
| Insulin-like growth factor-1 and insulin-like growth factor binding protein 3 and risk of postoperative cognitive dysfunction. | Jiang J et al. | β | 2015 | β |
| Paradoxical Associations of Insulin Resistance With Total and Cardiovascular Mortality in Humans. | Kim KS et al. | β | 2015 | β |
| What can long-lived mutants tell us about mechanisms causing aging and lifespan variation in natural environments? | Briga M et al. | β | 2015 | β |
| Exome sequencing of three cases of familial exceptional longevity. | Cash TP et al. | β | 2014 | β |
| Gene expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphic. | Arslan-Ergul A et al. | β | 2014 | β |
| Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis. | Debrabant B et al. | β | 2014 | β |
| Insulin-like growth factor-1 and risk of late-onset Alzheimer's disease: findings from a family study. | van Exel E et al. | β | 2014 | β |
| Association of heat shock proteins with all-cause mortality. | Broer L et al. | β | 2013 | β |
| Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children. | Kulminski AM et al. | β | 2013 | β |
| Exploring the role of genetic variability and lifestyle in oxidative stress response for healthy aging and longevity. | Dato S et al. | β | 2013 | β |
| GSK-3Ξ± is a central regulator of age-related pathologies in mice. | Zhou J et al. | β | 2013 | β |
| Inter-chromosomal level of genome organization and longevity-related phenotypes in humans. | Kulminski AM et al. | β | 2013 | β |
| The decay of stem cell nourishment at the niche. | Font de Mora J et al. | β | 2013 | β |
| The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway. | Wang M et al. | β | 2013 | β |
| Thyroid hormone signaling and homeostasis during aging. | Bowers J et al. | β | 2013 | β |
| Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations. | Kulminski AM et al. | β | 2013 | β |
| Aging and the survival of quiescent and non-quiescent cells in yeast stationary-phase cultures. | Werner-Washburne M et al. | β | 2012 | β |
| Are sirtuins viable targets for improving healthspan and lifespan? | Baur JA et al. | β | 2012 | β |
| Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies. | Soerensen M et al. | β | 2012 | β |
| Longevity candidate genes and their association with personality traits in the elderly. | Luciano M et al. | β | 2012 | β |
| A genome-wide association study of aging. | Walter S et al. | β | 2011 | β |
| Epigenetic control of aging. | MuΓ±oz-Najar U et al. | β | 2011 | β |
| Familial longevity is marked by enhanced insulin sensitivity. | Wijsman CA et al. | β | 2011 | β |
| GiSAO.db: a database for ageing research. | Hofer E et al. | β | 2011 | β |
| Immune aging and challenges for immune protection of the graying population. | Vallejo AN | β | 2011 | β |
| Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study. | Mooijaart SP et al. | β | 2011 | β |
| Postmyocardial infarct remodeling and heart failure: potential contributions from pro- and antiaging factors. | Idikio HA | β | 2011 | β |
| Respiratory chain cysteine and methionine usage indicate a causal role for thiyl radicals in aging. | Moosmann B | β | 2011 | β |
| An evolutionary genome scan for longevity-related natural selection in mammals. | Jobson RW et al. | β | 2010 | β |
| Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context. | Kulminski AM et al. | β | 2010 | β |
| Correlations of plasma cortisol levels, chaperone expression and mammalian longevity: a review of published data. | KrΓΈll J | β | 2010 | β |
| Dietary interventions to extend life span and health span based on calorie restriction. | Minor RK et al. | β | 2010 | β |
| Diet (zinc)-gene interaction related to inflammatory/immune response in ageing: possible link with frailty syndrome? | Mocchegiani E et al. | β | 2010 | β |
| Gene activation regresses atherosclerosis, promotes health, and enhances longevity. | Luoma PV | β | 2010 | β |
| Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains. | Leduc MS et al. | β | 2010 | β |
| Mutation and the evolution of ageing: from biometrics to system genetics. | Hughes KA | β | 2010 | β |
| Suitability of the clonal marbled crayfish for biogerontological research: a review and perspective, with remarks on some further crustaceans. | Vogt G | β | 2010 | β |
| The connections between general and reproductive senescence and the evolutionary basis of menopause. | Kirkwood TB et al. | β | 2010 | β |
| Aging influences wound healing in patients with chronic lower extremity wounds treated in a specialized Wound Care Center. | Wicke C et al. | β | 2009 | β |
| Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. | Yuan R et al. | β | 2009 | β |
| Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. | Pawlikowska L et al. | β | 2009 | β |
| Common gene signature of cancer and longevity. | Budovsky A et al. | β | 2009 | β |
| Environmental effects on sex differences in the genetic load for adult lifespan in a seed-feeding beetle. | Fox CW et al. | β | 2009 | β |
| Genetic determinants of ageing processes and diseases in later life. | Bostock CV et al. | β | 2009 | β |
| Human genetic variations: Beacons on the pathways to successful ageing. | Cluett C et al. | β | 2009 | β |
| Human insulin/IGF-1 and familial longevity at middle age. | Rozing MP et al. | β | 2009 | β |
| Mitochondrial polymorphisms are associated both with increased and decreased longevity. | Castri L et al. | β | 2009 | β |
| Quantitative physiology of Saccharomyces cerevisiae at near-zero specific growth rates. | Boender LG et al. | β | 2009 | β |
| The szilard hypothesis on the nature of aging revisited. | Zetterberg H et al. | β | 2009 | β |
| By studying ageing, endocrinology stays young. | van der Lely AJ | β | 2008 | β |
| New model of health promotion and disease prevention for the 21st century. | Butler RN et al. | β | 2008 | β |
| Zinc-gene interaction related to inflammatory/immune response in ageing. | Mocchegiani E et al. | β | 2008 | β |