CYP2E1 and oxidative liver injury by alcohol.
paper
Cited
Public
Unavailable
- Authors
- Lu, Yongke; Cederbaum, Arthur I
- Year
- 2008
- Journal
- Free radical biology & medicine
- PMID
- 18078827
- DOI
- 10.1016/j.freeradbiomed.2007.11.004
- PMCID
- PMC2268632
Ethanol-induced oxidative stress seems to play a major role in mechanisms by which ethanol causes liver injury. Many pathways have been suggested to contribute to the ability of ethanol to induce a state of oxidative stress. One central pathway seems to be the induction of cytochrome P450 2E1 (CYP2E1) by ethanol. CYP2E1 metabolizes and activates many toxicological substrates, including ethanol, to more reactive, toxic products. Levels of CYP2E1 are elevated under a variety of physiological and pathophysiological conditions and after acute and chronic alcohol treatment. CYP2E1 is also an effective generator of reactive oxygen species such as the superoxide anion radical and hydrogen peroxide and, in the presence of iron catalysts, produces powerful oxidants such as the hydroxyl radical. This review article summarizes some of the biochemical and toxicological properties of CYP2E1 and briefly describes the use of cell lines developed to constitutively express CYP2E1 and CYP2E1 knockout mice in assessing the actions of CYP2E1. Possible therapeutic implications for treatment of alcoholic liver injury by inhibition of CYP2E1 or CYP2E1-dependent oxidative stress will be discussed, followed by some future directions which may help us to understand the actions of CYP2E1 and its role in alcoholic liver injury.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| An Update on Animal Models of Alcohol-Associated Liver Disease. | Cao P et al. | β | 2026 | β |
| Bioactive nanoparticles from clam extracts mitigate alcoholic liver injury by modulating multiple pathways. | Kuo YR et al. | β | 2026 | β |
| Ethanol exacerbates noise-induced cochlear injury: Effects on hearing thresholds and hair cell loss. | Lee S et al. | β | 2026 | β |
| Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation. | Cui S et al. | β | 2026 | β |
| Fucoidan oligosaccharides alleviated alcoholic liver fibrosis by blocking the core fucosylation of TGF-Ξ² receptors via the JAK/STAT3/FUT8 axis. | Wang G et al. | β | 2026 | β |
| Hepatocyte-hepatic stellate cell interactions in liver fibrosis: Mechanisms and therapeutic implications. | Wang Z et al. | β | 2026 | β |
| Isobavachin Ameliorates Acetaminophen-Induced Liver Injury Through Modulation of CYP2E1-Mediated Bioactivation and NRF2/PI3K/AKT Cytoprotective Pathways. | Ye W et al. | β | 2026 | β |
| Metallothionein-dependent recovery of alcohol-related liver injury by zinc-glutathione. | Feng Y et al. | β | 2026 | β |
| Mitochondrial Calcium Signaling in Hepatocyte Health and Disease. | Eberhardt DR et al. | β | 2026 | β |
| Self-decreasing pH hydrolysis produces absorbed soybean peptides with enhanced hepatoprotection: The indispensable role of a tunable aromatic-pro-Arg/Lys motif. | Yu S et al. | β | 2026 | β |
| The Link between Alcohol Consumption and Kidney Injury. | Yokus B et al. | β | 2026 | β |
| Zonal hepatocellular responses to acute ethanol consumption: impacts on mitochondrial function and liver metabolism. | Savoca MT et al. | β | 2026 | β |
| Activation of hepatic alcohol metabolism by enzymatic porcine placenta hydrolysate in rats. | Shin J et al. | β | 2025 | β |
| A nano-pesticide with low toxicity for earthworms obtained by immobilizing avermectin onto Mg/Al layered double hydroxides. | Shi L et al. | β | 2025 | β |
| Ceramide kinase suppresses ferroptosis and protects against alcohol-associated liver disease through the p38 MAPK-HSPB1 pathway. | Tao Y et al. | β | 2025 | β |
| Curcumin Nanocarriers in the Protection Against Iron- and Alcohol-Induced Oxidative Stress in a Cellular Model of Liver Disease. | Petagine L et al. | β | 2025 | β |
| Cytochrome P450 as possible link between Mallory-Denk body formation in DDC-intoxicated mouse liver and human steatohepatitis. | Stumptner C et al. | β | 2025 | β |
| Decoding the Liver-Heart Axis in Cardiometabolic Diseases. | Capone F et al. | β | 2025 | β |
| Effects of Berberis vulgaris, and its active constituent berberine on cytochrome P450: a review. | Bathaei P et al. | β | 2025 | β |
| Effects of Crocus sativus and its active constituents on cytochrome P450: a review. | Bathaei P et al. | β | 2025 | β |
| Effects of periconceptional ethanol on mitochondrial content and oxidative stress in maternal liver and placentas from male and female fetuses in rats. | Steane SS et al. | β | 2025 | β |
| Effects of the Polar Fraction of <i>Lophocereus schottii</i> on Gene Expression and Hepatocyte Proliferation in a Wistar Rat Model of Hepatocellular Carcinoma. | Campos-Valdez M et al. | β | 2025 | β |
| Excessive alcohol consumption: a driver of metabolic dysfunction and inflammation. | Lee J et al. | β | 2025 | β |
| Food-derived alcohol dehydrogenase activating peptides: production, identification, structure-activity relationship, and mechanism of action. | Li M et al. | β | 2025 | β |
| Food plants as adjuvant medicines: a review of protective effects and clinical potential in alcoholic liver disease. | Li C et al. | β | 2025 | β |
| Genetic Polymorphisms of <i>ALDH2</i> and <i>ADH1B</i> in Alcohol-Induced Liver Injury: Molecular Mechanisms of Inflammation and Disease Progression in East Asian Populations. | Tadokoro T et al. | β | 2025 | β |
| Hemolytic Uremic Syndrome Complicated by Severe Neuropsychiatric Symptoms: A Case Report and Review of the Literature. | Wang D et al. | β | 2025 | β |
| Hepatic NMNAT1 is required to defend against alcohol-associated fatty liver disease. | Ding Q et al. | β | 2025 | β |
| Hepatoprotective Potential of <i>Murraya koenigii</i> (Curry Leaves) against Xenobiotics, Heavy Metals, and Hepatotoxic Agents: A Comprehensive Review. | Gangawat R et al. | β | 2025 | β |
| High-coverage whole-genome sequencing of a Jakun individual from the "Orang Asli" Proto-Malay subtribe from Peninsular Malaysia. | Yap WS et al. | β | 2025 | β |
| Impact of binge drinking on alcoholic liver disease. | Kang J et al. | β | 2025 | β |
| Induction of Cyp2e1 contributes to asparaginase-induced hepatocyte sensitization to lipotoxicity. | Zhu Y et al. | β | 2025 | β |
| In Vitro Metabolism of Doping Agents (Stanozolol, LGD-4033, Anastrozole, GW1516, Trimetazidine) by Human Seminal Vesicle and Liver Fractions. | Sternberg J et al. | β | 2025 | β |
| <i>Portulaca oleracea</i> L. extract relieve mice liver fibrosis by inhibiting TLR-4/NF-ΞΊB, Bcl-2/Bax and TGF-Ξ²1/Smad2 signalling transduction. | Meng X et al. | β | 2025 | β |
| Modulatory effects of CNNM4 on protein- l -isoaspartyl- O -methyltransferase repair function during alcohol-induced hepatic damage. | GonzΓ‘lez-Recio I et al. | β | 2025 | β |
| Neutral polysaccharide from Dendrobium officinale alleviates acute alcohol-induced liver injury via the gut microbiota-short chain fatty acids-liver axis. | Tao M et al. | β | 2025 | β |
| Oxidative stress in a cellular model of alcohol-related liver disease: protection using curcumin nanoformulations. | Petagine L et al. | β | 2025 | β |
| Oxidative Stress in Liver Metabolic Dysfunction and Diseases, with a Focus on Hepatogenic Diabetes: Effect of Alcohol Consumption. | Contreras-Zentella ML et al. | β | 2025 | β |
| Oxidative stress modulation in alcohol-related liver disease: From chinese botanical drugs to exercise-based interventions. | Zhu Y et al. | β | 2025 | β |
| Parental Alcohol Use Disrupts Offspring Mitochondrial Activity, Promoting Susceptibility to Toxicant-Induced Liver Cancer. | Basel A et al. | β | 2025 | β |
| Perfluorooctane sulfonate exposure and alcohol-associated liver disease severity in a mouse chronic-binge ethanol feeding model. | Ekuban FA et al. | β | 2025 | β |
| Perspective on alcohol-induced organ damage via autophagy-dependent cellular changes. | Bakheet A et al. | β | 2025 | β |
| Pharmacotherapy variability and precision medicine in neurocritical care. | Mahmoud SH et al. | β | 2025 | β |
| Phytol enhances catalase-dependent ethanol metabolism in liver independent of PPARΞ±. | Mazur A et al. | β | 2025 | β |
| Post-COVID metabolic enzyme alterations in K18-hACE2 mice exacerbate alcohol-induced liver injury through transcriptional regulation. | Park S et al. | β | 2025 | β |
| Prolonged Intestinal Ethanol Absorption and Oxidative Stress: Revisiting the Gut-Liver Axis in Alcohol-Associated Disease. | Chung BS et al. | β | 2025 | β |
| Protective effects of boric acid on HBV-transgenic mice with chronic alcohol consumption: An experimental study. | Erguven P et al. | β | 2025 | β |
| Roles of Oxidative Stress and Autophagy in Alcohol-Mediated Brain Damage. | Ruiter-Lopez L et al. | β | 2025 | β |
| Temporal changes of hepatic drug-metabolizing enzymes mediated by hepatic ischemia-reperfusion injury and the protective effect of Oridonin. | Gu T et al. | β | 2025 | β |
| Theaflavin-3,3'-digallate prevents alcoholic liver injury by suppressing hepatic TLR4/NF-ΞΊB signaling and modulating the gut-liver axis in mice. | Tang MG et al. | β | 2025 | β |
| The alcohol exposome. | Sabet NH et al. | β | 2025 | β |
| The Pathophysiology of Alcohol-Associated Liver Disease: Focusing on Superoxide Dismutase 1 as a Therapeutic Target. | Gopal T et al. | β | 2025 | β |
| TIPE2 deficiency amplifies inflammation and immune dysregulation in MASH through modulating hepatic lipid metabolism and immune cell function. | Rabiu L et al. | β | 2025 | β |
| Transcriptional Regulation of CYP2E1: Promoter Methylation in In Vitro Models and Human Liver Disease Samples. | Komaniecka N et al. | β | 2025 | β |
| A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death. | Allevato MM et al. | β | 2024 | β |
| CYP2E1 mediated advanced oxidation protein products exacerbate acetaminophen induced drug-derived liver injury in vitro and in vivo. | Xun T et al. | β | 2024 | β |
| Degradation effects and mechanisms of <i>Limosilactobacillus fermentum</i> on ethanol. | Zhang L et al. | β | 2024 | β |
| Different ethanol exposure durations affect cytochrome P450 2E1-mediated sevoflurane metabolism in rat liver. | Jiang W et al. | β | 2024 | β |
| Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: a metabolic mechanism perspective. | Rani J et al. | β | 2024 | β |
| Effects of Dietary Supplementations of Vitamin C, Organic Selenium, Betaine, and Pomegranate Peel on Alleviating the Effect of Heat Stress on Growing Rabbits. | Abu Hafsa SH et al. | β | 2024 | β |
| ERRΞ³-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress. | Jung YS et al. | β | 2024 | β |
| Folic acid antioxidant supplementation to binge drinking adolescent rats improves hydric-saline balance and blood pressure, but fails to increase renal NO availability and glomerular filtration rate. | Gallego-LΓ³pez MDC et al. | β | 2024 | β |
| Hemochromatosis: Ferroptosis, ROS, Gut Microbiome, and Clinical Challenges with Alcohol as Confounding Variable. | Teschke R | β | 2024 | β |
| Hepatocyte-Targeted Lipid Nanoparticle Delivery of HERC2 Plasmid Controls Drug-Induced Hepatotoxicity by Limiting Ξ²-Catenin-Regulated CYP2E1 Expression. | Liu Y et al. | β | 2024 | β |
| Hepatoprotection of capsaicin in alcoholic and non-alcoholic fatty liver diseases. | Karimi-Sales E et al. | β | 2024 | β |
| Hydroxysafflor yellow A ameliorates alcohol-induced liver injury through PI3K/Akt and STAT3/NF-ΞΊB signaling pathways. | Wang W et al. | β | 2024 | β |
| Imaging of Alcohol-Associated Liver Disease. | Maheshwari S et al. | β | 2024 | β |
| Interaction between fatty acid oxidation and ethanol metabolism in liver. | Lu Y et al. | β | 2024 | β |
| Key regulators of hepatic stellate cell activation in alcohol liver Disease: A comprehensive review. | Patidar P et al. | β | 2024 | β |
| Loss of GCN5L1 exacerbates damage in alcoholic liver disease through ferroptosis activation. | Yang C et al. | β | 2024 | β |
| Mitochondrial quality control in alcohol-associated liver disease. | Thoudam T et al. | β | 2024 | β |
| Preparation of <i>Pueraria lobata</i> Root-Derived Exosome-Like Nanovesicles and Evaluation of Their Effects on Mitigating Alcoholic Intoxication and Promoting Alcohol Metabolism in Mice. | Zhang W et al. | β | 2024 | β |
| Protective Effect and Mechanism of L-Theanine on Acute Alcoholic Liver Injury in Mice. | Liu MY et al. | β | 2024 | β |
| Protective Effects of Cereal Grain Extracts on Alcohol-Induced Hepatocyte Damage. | Song J et al. | β | 2024 | β |
| SPRTN is involved in hepatocellular carcinoma development through the ER stress response. | Batel A et al. | β | 2024 | β |
| The antioxidant peptides from walnut protein hydrolysates and their protective activity against alcoholic injury. | Chen P et al. | β | 2024 | β |
| The Interplay between Endogenous and Foodborne Pro-Oxidants and Antioxidants in Shaping Redox Homeostasis. | Jakubek P et al. | β | 2024 | β |
| The protective effect of Enteromorpha prolifera polysaccharide on alcoholic liver injury in C57BL/6 mice. | Yan T et al. | β | 2024 | β |
| Wine, Polyphenols, and the Matrix Effect: Is Alcohol Always the Same? | Miraldi E et al. | β | 2024 | β |
| Alcohol, White Adipose Tissue, and Brown Adipose Tissue: Mechanistic Links to Lipogenesis and Lipolysis. | Li Q et al. | β | 2023 | β |
| Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by <i>inΒ vivo</i> RNAi targeting <i>Cyp2e1</i>. | Wang Y et al. | β | 2023 | β |
| A Microfluidic Device for Long-Term Maintenance of Organotypic Liver Cultures. | Vega JMH et al. | β | 2023 | β |
| Associations of hypomagnesemia in patients seeking a first treatment of alcohol use disorder. | HernΓ‘ndez-Rubio A et al. | β | 2023 | β |
| Autophagy, Oxidative Stress, and Alcoholic Liver Disease: A Systematic Review and Potential Clinical Applications. | Salete-Granado D et al. | β | 2023 | β |
| Binge drinking leads to an oxidative and metabolic imbalance in skeletal muscle during adolescence in rats: endocrine repercussion. | Romero-Herrera I et al. | β | 2023 | β |
| Caulerpa lentillifera improves ethanol-induced liver injury and modulates the gut microbiota in rats. | Lin KY et al. | β | 2023 | β |
| Cyp3A4 *1G polymorphism is associated with alcohol drinking: A 5-year retrospective single centered population-based study in China. | Jia X et al. | β | 2023 | β |
| DNA Methylation in Alcohol Use Disorder. | Zheng Q et al. | β | 2023 | β |
| Fatty Acid Ethyl Ethers: New Modulators of Acute Ethanol-Mediated Hepatotoxicity? | Anton P et al. | β | 2023 | β |
| Fermented <i>Aloe arborescens</i> Miller Leaf Extract Suppresses Acute Alcoholic Liver Injury via Antioxidant and Anti-Inflammatory Effects in C57BL/6J Mice. | Kim MJ et al. | β | 2023 | β |
| Hepatitis Delta Virus Antigens Trigger Oxidative Stress, Activate Antioxidant Nrf2/ARE Pathway, and Induce Unfolded Protein Response. | Smirnova OA et al. | β | 2023 | β |
| Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases. | Cui S et al. | β | 2023 | β |
| Interaction between dual specificity phosphatase-1 and cullin-1 attenuates alcohol-related liver disease by restoring p62-mediated mitophagy. | Li R et al. | β | 2023 | β |
| Lutein Prevents Liver Injury and Intestinal Barrier Dysfunction in Rats Subjected to Chronic Alcohol Intake. | Zhao S et al. | β | 2023 | β |
| New insights in the pathogenesis of alcohol-related liver disease: The metabolic, immunologic, and neurologic pathways<sup>β</sup>. | Ryu T et al. | β | 2023 | β |
| Pathological role of methionine in the initiation and progression of biliary atresia. | Jiachen Z et al. | β | 2023 | β |
| Regulatory effect of moderate Jiang-flavour baijiu (Chinese liquor) dosage on organ function and gut microbiota in mice. | Wang H et al. | β | 2023 | β |
| Research progress on the P2X7 receptor in liver injury and hepatocellular carcinoma. | Li X et al. | β | 2023 | β |
| Small-molecule chemical probes for the potential therapeutic targets in alcoholic liver diseases. | Dogra A et al. | β | 2023 | β |
| Spectrum-effect relationship study to reveal the pharmacodynamic substances in Flos Puerariae-Semen Hoveniae medicine pair for the treatment of alcohol-induced liver damage. | Zhang H et al. | β | 2023 | β |
| Steatotic Liver Disease: Metabolic Dysfunction, Alcohol, or Both? | Staufer K et al. | β | 2023 | β |
| Structure and hepatoprotective activity of Usp10/NF-ΞΊB/Nrf2 pathway-related Morchella esculenta polysaccharide. | Teng S et al. | β | 2023 | β |
| The effect of liver disease on hepatic microenvironment and implications for immune therapy. | Brown ZJ et al. | β | 2023 | β |
| Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease. | Gutierrez AH et al. | β | 2023 | β |
| Under peroxisome proliferation acyl-CoA oxidase coordinates with catalase to enhance ethanol metabolism. | Chen X et al. | β | 2023 | β |
| A Comparison of Mesenchymal Stem Cell-derived Hepatocyte-like Cells and HepG2 Cells for Use in Drug-Induced Liver Injury Studies. | Perera D et al. | β | 2022 | β |
| Advancements in the Alcohol-Associated Liver Disease Model. | Zhu L et al. | β | 2022 | β |
| Alcohol-Associated Tissue Injury: Current Views on Pathophysiological Mechanisms. | Simon L et al. | β | 2022 | β |
| Alcohol-Related Liver Disease: An Overview on Pathophysiology, Diagnosis and Therapeutic Perspectives. | Ha Y et al. | β | 2022 | β |
| Alcohol use patterns and risk of incident cataract surgery: a large scale case-control study in Japan. | Fukai K et al. | β | 2022 | β |
| A retinoic acid receptor Ξ²2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes. | Melis M et al. | β | 2022 | β |
| Binge drinking during the adolescence period causes oxidative damage-induced cardiometabolic disorders: A possible ameliorative approach with selenium supplementation. | Ojeda ML et al. | β | 2022 | β |
| CD73-Adenosine A<sub>1</sub>R Axis Regulates the Activation and Apoptosis of Hepatic Stellate Cells Through the PLC-IP<sub>3</sub>-Ca<sup>2+</sup>/DAG-PKC Signaling Pathway. | Liu Z et al. | β | 2022 | β |
| Could Alcohol Abuse and Dependence on Junk Foods Inducing Obesity and/or Illicit Drug Use Represent Danger to Liver in Young People with Altered Psychological/Relational Spheres or Emotional Problems? | Tarantino G et al. | β | 2022 | β |
| Crosstalk between CYP2E1 and PPAR<i>Ξ±</i> substrates and agonists modulate adipose browning and obesity. | Zhang Y et al. | β | 2022 | β |
| Crosstalk between Oxidative Stress and Inflammatory Liver Injury in the Pathogenesis of Alcoholic Liver Disease. | Yang YM et al. | β | 2022 | β |
| Current Therapeutic Options and Potential of Mesenchymal Stem Cell Therapy for Alcoholic Liver Disease. | Han J et al. | β | 2022 | β |
| CYP2E1-dependent upregulation of SIRT7 is response to alcohol mediated metastasis in hepatocellular carcinoma. | Zhang C et al. | β | 2022 | β |
| Differentially Expressed Hepatic Genes Revealed by Transcriptomics in Pigs with Different Liver Lipid Contents. | Lyu W et al. | β | 2022 | β |
| Diurnal Variation in Biomarkers of Exposure to Endocrine-Disrupting Chemicals and Their Association with Oxidative Damage in Norwegian Adults: The EuroMix Study. | Abimbola SO et al. | β | 2022 | β |
| Effects of Regular Low-Level Alcohol Consumption in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Crossover Study. | Oshima S et al. | β | 2022 | β |
| Endoplasmic reticulum-targeted inhibition of CYP2E1 with vitamin E nanoemulsions alleviates hepatocyte oxidative stress and reverses alcoholic liver disease. | Shi Y et al. | β | 2022 | β |
| Ethanol Metabolism in the Liver, the Induction of Oxidant Stress, and the Antioxidant Defense System. | Contreras-Zentella ML et al. | β | 2022 | β |
| Folic Acid Homeostasis and Its Pathways Related to Hepatic Oxidation in Adolescent Rats Exposed to Binge Drinking. | Gallego-Lopez MDC et al. | β | 2022 | β |
| Ginsenoside Rc Modulates SIRT6-NRF2 Interaction to Alleviate Alcoholic Liver Disease. | Pan Z et al. | β | 2022 | β |
| <i>Levilactobacillus brevis</i> MG5311 Alleviates Ethanol-Induced Liver Injury by Suppressing Hepatic Oxidative Stress in C57BL/6 Mice. | Jung H et al. | β | 2022 | β |
| Important Drug-Drug Interactions for the Addiction Psychiatrist. | Sandson N | β | 2022 | β |
| Increased serum anti-CYP2E1 IgG autoantibody levels may be involved in the pathogenesis of occupational trichloroethylene hypersensitivity syndrome: a case-control study. | Nakajima T et al. | β | 2022 | β |
| Investigation of CYP2E1 and Caspase-3 Gene Expressions in COVID-19 patients. | Karabulut Uzuncakmak S et al. | β | 2022 | β |
| <i>Periplaneta americana</i> extract alleviates steatohepatitis in a mouse model by modulating HMGB1-mediated inflammatory response. | Xiao Y et al. | β | 2022 | β |
| <i>Poria cocos</i> polysaccharide prevents alcohol-induced hepatic injury and inflammation by repressing oxidative stress and gut leakiness. | Jiang YH et al. | β | 2022 | β |
| Lactoferrin Prevents Chronic Alcoholic Injury by Regulating Redox Balance and Lipid Metabolism in Female C57BL/6J Mice. | Li DM et al. | β | 2022 | β |
| Mice lacking Ξ±4 nicotinic acetylcholine receptors are protected against alcohol-associated liver injury. | Watson WH et al. | β | 2022 | β |
| Myricetin (3,3<sup>'</sup>,4<sup>'</sup>,5,5<sup>'</sup>,7-hexahydroxyflavone) prevents ethanol-induced biochemical and inflammatory damage in the liver of Wistar rats. | Ahmad SB et al. | β | 2022 | β |
| Novel Insights into Alcoholic Liver Disease: Iron Overload, Iron Sensing and Hemolysis. | Mueller S et al. | β | 2022 | β |
| Potential Effect of Enzymatic Porcine Placental Hydrolysate (EPPH) to Improve Alcoholic Liver Disease (ALD) by Promoting Lipolysis in the Liver. | Lee HY et al. | β | 2022 | β |
| PPARΞ± agonist WY-14,643 induces the PLA2/COX-2/ACOX1 pathway to enhance peroxisomal lipid metabolism and ameliorate alcoholic fatty liver in mice. | Xu Y et al. | β | 2022 | β |
| Probiotic-fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota. | Zhao W et al. | β | 2022 | β |
| Protective effects of curcumin/cyclodextrin polymer inclusion complex against hydrogen peroxide-induced LO2 cells damage. | Chen J et al. | β | 2022 | β |
| Purpurin ameliorates alcohol-induced hepatotoxicity by reducing ROS generation and promoting Nrf2 expression. | Hussain Y et al. | β | 2022 | β |
| Role of antioxidants and oxidative stress in the evolution of acute pancreatitis (Review). | PΔdureanu V et al. | β | 2022 | β |
| Role of mechanistic target of rapamycin in autophagy and alcohol-associated liver disease. | Chao X et al. | β | 2022 | β |
| The case for FAT10 as a novel target in fatty liver diseases. | Wimalarathne MM et al. | β | 2022 | β |
| Turmeric extract (<i>Curcuma longa</i> L.) regulates hepatic toxicity in a single ethanol binge rat model. | Lee HY et al. | β | 2022 | β |
| Vitamin C alleviates alcoholic liver injury by suppressing neutrophil infiltration in senescence marker protein 30-knockout mice irrespective of its antioxidant effects. | Baek SM et al. | β | 2022 | β |
| Vitamin Supplements as a Nutritional Strategy against Chronic Alcohol Consumption? An Updated Review. | Sandoval C et al. | β | 2022 | β |
| Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis. | Hamada K et al. | β | 2022 | β |
| Ξ²-Carotene Increases Activity of Cytochrome P450 2E1 during Ethanol Consumption. | Sandoval C et al. | β | 2022 | β |
| 10-Dehydrogingerdione ameliorates renal endoplasmic reticulum/oxidative stress and apoptosis in alcoholic nephropathy induced in experimental rats. | Elnagar GM et al. | β | 2021 | β |
| 3-B-RUT, a derivative of RUT, protected against alcohol-induced liver injury by attenuating inflammation and oxidative stress. | Xu JJ et al. | β | 2021 | β |
| Alcoholic liver disease-from steatosis to cirrhosis - a biochemistry approach. | Cioarca-Nedelcu R et al. | β | 2021 | β |
| A review of the role of ethanol-induced adipose tissue dysfunction in alcohol-associated liver disease. | Gopal T et al. | β | 2021 | β |
| Chlorogenic Acid Protects against Advanced Alcoholic Steatohepatitis in Rats via Modulation of Redox Homeostasis, Inflammation, and Lipogenesis. | Buko V et al. | β | 2021 | β |
| Curcumin Can be Acts as Effective agent for Prevent or Treatment of Alcohol-induced Toxicity in Hepatocytes: An Illustrated Mechanistic Review. | Salehi E et al. | β | 2021 | β |
| CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload. | HarjumΓ€ki R et al. | β | 2021 | β |
| Downregulation of Glutathione-Mediated Detoxification Capacity by Binge Drinking Aggravates Acetaminophen-Induced Liver Injury through IRE1Ξ± ER Stress Signaling. | Kim SH et al. | β | 2021 | β |
| Epigenetic Biomarkers of Transition from Metabolically Healthy Obesity to Metabolically Unhealthy Obesity Phenotype: A Prospective Study. | GutiΓ©rrez-Repiso C et al. | β | 2021 | β |
| Fermentation of Sprouted Ginseng (<i>Panax ginseng</i>) Increases Flavonoid and Phenolic Contents to Attenuate Alcoholic Hangover and Acute Liver Injury in Mice. | Je J et al. | β | 2021 | β |
| Ginger (<i>Zingiber officinale</i> roscoe) extract could upregulate the renal expression of <i>NRF2</i> and <i>TNFΞ±</i> and prevents ethanol-induced toxicity in rat kidney. | Fathi R et al. | β | 2021 | β |
| Hepatoprotection by Ginsenoside Rg1 in alcoholic liver disease. | Yang C et al. | β | 2021 | β |
| H<sub>2</sub>O<sub>2</sub>-mediated autophagy during ethanol metabolism. | Chen C et al. | β | 2021 | β |
| Impact of body mass and alcohol consumption on all-cause and liver mortality in 240β000 adults in the United States. | Patra J et al. | β | 2021 | β |
| Lactic Acid Bacteria Exert a Hepatoprotective Effect against Ethanol-Induced Liver Injury in HepG2 Cells. | Lee JY et al. | β | 2021 | β |
| <i>S</i>-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling. | Luo P et al. | β | 2021 | β |
| Oligopeptides from Jinhua ham prevent alcohol-induced liver damage by regulating intestinal homeostasis and oxidative stress in mice. | Nie W et al. | β | 2021 | β |
| Pathophysiological Aspects of Alcohol Metabolism in the Liver. | Hyun J et al. | β | 2021 | β |
| PPARΞ± agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase. | Chen X et al. | β | 2021 | β |
| PPARΞ± agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1. | Xu Y et al. | β | 2021 | β |
| Protective Role of Vanillic Acid against Diethylnitrosamine- and 1,2-Dimethylhydrazine-Induced Hepatocarcinogenesis in Rats. | Punvittayagul C et al. | β | 2021 | β |
| Red Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in Mice Fed Alcohol Liquid Diet. | Lin TA et al. | β | 2021 | β |
| Salidroside alleviates liver inflammation in furan-induced mice by regulating oxidative stress and endoplasmic reticulum stress. | Yuan Y et al. | β | 2021 | β |
| Selenium, a dietary-antioxidant with cardioprotective effects, prevents the impairments in heart rate and systolic blood pressure in adolescent rats exposed to binge drinking treatment. | Ojeda ML et al. | β | 2021 | β |
| Stability investigations of cytochrome P450 (CYP) enzymes immediately after death in a pig model support the applicability of postmortem hepatic CYP quantification. | Pedersen KW et al. | β | 2021 | β |
| Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway. | Ishida K et al. | β | 2021 | β |
| The Timing and Effects of Low-Dose Ethanol Treatment on Acetaminophen-Induced Liver Injury. | Liu FC et al. | β | 2021 | β |
| Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease. | Jiang Y et al. | β | 2020 | β |
| An activatable probe for detecting alcoholic liver injury via multispectral optoacoustic tomography and fluorescence imaging. | Chen J et al. | β | 2020 | β |
| A novel acidic polysaccharide from the residue of Panax notoginseng and its hepatoprotective effect on alcoholic liver damage in mice. | Wang C et al. | β | 2020 | β |
| Combined alcoholic and non-alcoholic steatohepatitis. | Ntandja Wandji LC et al. | β | 2020 | β |
| Comparative liver metabolic enzyme activity of cytochrome P450 and glutathione-S-transferase in crocodile (Crocodylus siamensis) and livestock. | Thiendedsakul P et al. | β | 2020 | β |
| Current Treatment Options for HCC: From Pharmacokinetics to Efficacy and Adverse Events in Liver Cirrhosis. | Galati G et al. | β | 2020 | β |
| Danger signals in liver injury and restoration of homeostasis. | Han H et al. | β | 2020 | β |
| Dipeptide YA is Responsible for the Positive Effect of Oyster Hydrolysates on Alcohol Metabolism in Single Ethanol Binge Rodent Models. | Siregar AS et al. | β | 2020 | β |
| Effect of Single-Dose, Oral Enzymatic Porcine Placental Extract on Pharmacokinetics of Alcohol and Liver Function in Rats. | Kim HJ et al. | β | 2020 | β |
| Effects of insulin treatment on hepatic CYP1A1 and CYP2E1 activities and lipid peroxidation levels in streptozotocin-induced diabetic rats. | Kuzgun G et al. | β | 2020 | β |
| Ethanol-Induced Oxidative Stress Modifies Inflammation and Angiogenesis Biomarkers in Retinal Pigment Epithelial Cells (ARPE-19): Role of CYP2E1 and its Inhibition by Antioxidants. | Martinez-Gil N et al. | β | 2020 | β |
| Functional characterization of the chlorzoxazone 6-hydroxylation activity of human cytochrome P450 2E1 allelic variants in Han Chinese. | Wang T et al. | β | 2020 | β |
| Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice. | Hsu MF et al. | β | 2020 | β |
| Higher sensitivity of female cells to ethanol: methylation of DNA lowers Cyp2e1, generating more ROS. | Penaloza CG et al. | β | 2020 | β |
| <i>Hylocereus polyrhizus</i> Peel Extract Retards Alcoholic Liver Disease Progression by Modulating Oxidative Stress and Inflammatory Responses in C57BL/6 Mice. | Yeh WJ et al. | β | 2020 | β |
| <i>Polygonum minus</i> essential oil modulates cisplatin-induced hepatotoxicity through inflammatory and apoptotic pathways. | Abd Rashid N et al. | β | 2020 | β |
| Jujube (<i>Ziziphus jujuba</i> Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation. | Hong S et al. | β | 2020 | β |
| MEHP/ethanol co-exposure favors the death of steatotic hepatocytes, possibly through CYP4A and ADH involvement. | TΓͺte A et al. | β | 2020 | β |
| Microfluidic confinement enhances phenotype and function of hepatocyte spheroids. | Choi JH et al. | β | 2020 | β |
| Molecular mechanisms of protective roles of isoflavones against chemicals-induced liver injuries. | Alipour MR et al. | β | 2020 | β |
| Nanoformulated SOD1 ameliorates the combined NASH and alcohol-associated liver disease partly via regulating CYP2E1 expression in adipose tissue and liver. | Gopal T et al. | β | 2020 | β |
| Physicochemical properties and hepatoprotective effects of glycated Snapper fish scale peptides conjugated with xylose via maillard reaction. | Chen X et al. | β | 2020 | β |
| Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease. | Shim YR et al. | β | 2020 | β |
| Role of Mechanistic Target of Rapamycin and Autophagy in Alcohol-Induced Adipose Atrophy and Liver Injury. | Li Y et al. | β | 2020 | β |
| Self-assembled Angelica sinensis polysaccharide nanoparticles with an instinctive liver-targeting ability as a drug carrier for acute alcoholic liver damage protection. | Wang K et al. | β | 2020 | β |
| The Potential Benefit of Monitoring Oxidative Stress and Inflammation in the Prevention of Non-Communicable Diseases (NCDs). | Seyedsadjadi N et al. | β | 2020 | β |
| Therapeutic potency of fermented field water-dropwort (<i>Oenanthe javanica</i> (Blume) DC.) in ethanol-induced liver injury. | Lee DH et al. | β | 2020 | β |
| Vinegar extract ameliorates alcohol-induced liver damage associated with the modulation of gut microbiota in mice. | Xia T et al. | β | 2020 | β |
| Vitamin D Deficiency Aggravates Hepatic Oxidative Stress and Inflammation during Chronic Alcohol-Induced Liver Injury in Mice. | Hu CQ et al. | β | 2020 | β |
| Alcohol abuse and disorder of granulopoiesis. | Shi X et al. | β | 2019 | β |
| A prospective study of the incidence of drug-induced liver injury by the modern volatile anaesthetics sevoflurane and desflurane. | Bishop B et al. | β | 2019 | β |
| Babao Dan attenuates acute ethanol-induced liver injury via Nrf2 activation and autophagy. | Yu Y et al. | β | 2019 | β |
| Curcumin-galactomannosides mitigate alcohol-induced liver damage by inhibiting oxidative stress, hepatic inflammation, and enhance bioavailability on TLR4/MMP events compared to curcumin. | Mohan R et al. | β | 2019 | β |
| Diallyl disulfide inhibits ethanol-induced pulmonary cell vitamin D and antimicrobial peptide cathelicidin depletion. | Ogunsakin O et al. | β | 2019 | β |
| Effects of <i>Eriobotrya japonica</i> Water Extract on Alcoholic and Nonalcoholic Fatty Liver Impairment. | Mun J et al. | β | 2019 | β |
| Ethanol and its metabolites: update on toxicity, benefits, and focus on immunomodulatory effects. | Le DarΓ© B et al. | β | 2019 | β |
| Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook. | Singh L et al. | β | 2019 | β |
| Fine Tuning of Hepatocyte Differentiation from Human Embryonic Stem Cells: Growth Factor <i>vs.</i> Small Molecule-Based Approaches. | Varghese DS et al. | β | 2019 | β |
| Future Directions of Pharmacovigilance Studies Using Electronic Medical Recording and Human Genetic Databases. | Choi YH et al. | β | 2019 | β |
| In Vivo Hepatoprotective Effects of a Peptide Fraction from Krill Protein Hydrolysates against Alcohol-Induced Oxidative Damage. | Park SY et al. | β | 2019 | β |
| Lipid peroxidation derived reactive aldehydes in alcoholic liver disease. | Ali H et al. | β | 2019 | β |
| Methionine adenosyltransferases in liver cancer. | Murray B et al. | β | 2019 | β |
| Methionine Adenosyltransferase Ξ±1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression. | Murray B et al. | β | 2019 | β |
| Microsomal Ethanol-Oxidizing System: Success Over 50 Years and an Encouraging Future. | Teschke R | β | 2019 | β |
| Natural compounds in the chemoprevention of alcoholic liver disease. | Tu Y et al. | β | 2019 | β |
| Orally administration of <i>Neolentinus lepideus</i> extracts attenuated ethanol induced accumulation of hepatic lipid in mice. | Park KM et al. | β | 2019 | β |
| Oxidative stress in biological systems and its relation with pathophysiological functions: the effect of physical activity on cellular redox homeostasis. | Kruk J et al. | β | 2019 | β |
| Peroxiredoxin 6 Confers Protection Against Nonalcoholic Fatty Liver Disease Through Maintaining Mitochondrial Function. | Lee DH et al. | β | 2019 | β |
| Plasma exosomes exacerbate alcohol- and acetaminophen-induced toxicity via CYP2E1 pathway. | Rahman MA et al. | β | 2019 | β |
| Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation. | Zheng J et al. | β | 2019 | β |
| Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis. | Li D et al. | β | 2019 | β |
| Role and mechanisms of autophagy in alcohol-induced liver injury. | Chao X et al. | β | 2019 | β |
| Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice. | Chen X et al. | β | 2019 | β |
| The Immunogenicity in Mice of HCV Core Delivered as DNA Is Modulated by Its Capacity to Induce Oxidative Stress and Oxidative Stress Response. | Jansons J et al. | β | 2019 | β |
| The role of cytochrome P450 2E1 on ethanol-mediated oxidative stress and HIV replication in human monocyte-derived macrophages. | Gong Y et al. | β | 2019 | β |
| The Significance of Lactoperoxidase System in Oral Health: Application and Efficacy in Oral Hygiene Products. | Magacz M et al. | β | 2019 | β |
| 2,4-Dimethylaniline generates phosphorylated histone H2AX in human urothelial and hepatic cells through reactive oxygen species produced by cytochrome P450 2E1. | Qi Y et al. | β | 2018 | β |
| Alcoholic Hepatitis: Lost in Translation. | Woolbright BL et al. | β | 2018 | β |
| Alcoholic Liver Disease: Alcohol Metabolism, Cascade of Molecular Mechanisms, Cellular Targets, and Clinical Aspects. | Teschke R | β | 2018 | β |
| Antioxidant Activity and Protective Effects of Enzyme-Extracted Oudemansiella radiata Polysaccharides on Alcohol-Induced Liver Injury. | Wang X et al. | β | 2018 | β |
| Antiulcer Activity and Potential Mechanism of Action of the Leaves of <i>Spondias mombin</i> L. | Brito SA et al. | β | 2018 | β |
| Aqueous Extract of Pepino (<i>Solanum muriactum</i> Ait) Leaves Ameliorate Lipid Accumulation and Oxidative Stress in Alcoholic Fatty Liver Disease. | Hsu JY et al. | β | 2018 | β |
| Astaxanthin alleviated ethanol-induced liver injury by inhibition of oxidative stress and inflammatory responses via blocking of STAT3 activity. | Han JH et al. | β | 2018 | β |
| A Unifying Hypothesis Linking Hepatic Adaptations for Ethanol Metabolism to the Proinflammatory and Profibrotic Events of Alcoholic Liver Disease. | Zhong Z et al. | β | 2018 | β |
| Chemical constituents from Sambucus williamsii Hance fruits and hepatoprotective effects in mouse hepatocytes. | Kuang H et al. | β | 2018 | β |
| Cytochrome P450s and Alcoholic Liver Disease. | Lu Y et al. | β | 2018 | β |
| Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats. | Yu JY et al. | β | 2018 | β |
| Effects of Digeda-4 Decoction on the CYP450 Activities in Rats Using a Cocktail Method by HPLC. | Zhang D et al. | β | 2018 | β |
| Evaluating the effect of diallyl sulfide on regulation of inflammatory mRNA expression in 3T3L1 adipocytes and RAW 264.7 macrophages during ethanol treatment. | Kema VH et al. | β | 2018 | β |
| From hepatofibrosis to hepatocarcinogenesis: Higher cytochrome P450 2E1 activity is a potential risk factor. | Gao J et al. | β | 2018 | β |
| High-throughput toxicity testing of chemicals and mixtures in organotypic multi-cellular cultures of primary human hepatic cells. | Orbach SM et al. | β | 2018 | β |
| Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver. | Zeng T et al. | β | 2018 | β |
| Inhibition of Formation of Azoxymethane-induced Colonic Aberrant Crypt Foci in Rats by Edible Green Algae <i>Capsosiphon fulvescens</i> and Brown Algae <i>Hizikia fusiforme</i>. | Son YS et al. | β | 2018 | β |
| Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish. | Bambino K et al. | β | 2018 | β |
| In silico prediction of potential chemical reactions mediated by human enzymes. | Yu MS et al. | β | 2018 | β |
| Investigating the CYP2E1 Potential Role in the Mechanisms Behind INH/LPS-Induced Hepatotoxicity. | Hassan HM et al. | β | 2018 | β |
| In vitro evaluation of structural analogs of diallyl sulfide as novel CYP2E1 inhibitors for their protective effect against xenobiotic-induced toxicity and HIV replication. | Rahman MA et al. | β | 2018 | β |
| Kaempferol's Protective Effect on Ethanol-Induced Mouse Primary Hepatocytes Injury Involved in the Synchronous Inhibition of SP1, Hsp70 and CYP2E1. | Zhou B et al. | β | 2018 | β |
| Mild drinking habit is a risk factor for hepatocarcinogenesis in non-alcoholic fatty liver disease with advanced fibrosis. | Kimura T et al. | β | 2018 | β |
| Modulators of Redox Metabolism in Head and Neck Cancer. | Chen X et al. | β | 2018 | β |
| Mouse models of hepatocellular carcinoma: an overview and highlights for immunotherapy research. | Brown ZJ et al. | β | 2018 | β |
| Neurotoxicity, behavioral changes and gene-expression profile of mice exposed to SnS<sub>2</sub> nanoflowers. | Bai D et al. | β | 2018 | β |
| Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5. | Chen X et al. | β | 2018 | β |
| Nrf2 in alcoholic liver disease. | Sun J et al. | β | 2018 | β |
| Polymorphisms of drug-metabolizing enzyme CYP2E1 in Chinese Uygur population. | Zhu L et al. | β | 2018 | β |
| Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure. | Bucher S et al. | β | 2018 | β |
| Protective effect of <i>Ruellia tuberosa</i>Β L. extracts against abnormal expression of hepatic detoxification enzymes in diabetic rats. | Chang WC et al. | β | 2018 | β |
| Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway. | Na AY et al. | β | 2018 | β |
| Role of lipid mediators in the regulation of oxidative stress and inflammatory responses in dairy cattle. | Mavangira V et al. | β | 2018 | β |
| Sasa quelpaertensis leaves ameliorate alcohol-induced liver injury by attenuating oxidative stress in HepG2 cells and mice. | Madushani Herath KHIN et al. | β | 2018 | β |
| Sources of free radicals and oxidative stress in the oral cavity. | Ε»ukowski P et al. | β | 2018 | β |
| The antioxidant activities of alkalic-extractable polysaccharides from Coprinus comatus on alcohol-induced liver injury in mice. | Zhao H et al. | β | 2018 | β |
| The Effect of Ethanol on Telomere Dynamics and Regulation in Human Cells. | Harpaz T et al. | β | 2018 | β |
| The Lieber-DeCarli Diet-A Flagship Model for Experimental Alcoholic Liver Disease. | Guo F et al. | β | 2018 | β |
| Trichloroethylene exposure results in the phosphorylation of histone H2AX in a human hepatic cell line through cytochrome P450 2E1-mediated oxidative stress. | Toyooka T et al. | β | 2018 | β |
| 1,2-Dichloropropane generates phosphorylated histone H2AX via cytochrome P450 2E1-mediated metabolism. | Toyooka T et al. | β | 2017 | β |
| Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame. | Ramadori P et al. | β | 2017 | β |
| Alcoholic Liver Disease: from CYP2E1 to CYP2A5. | Leung TM et al. | β | 2017 | β |
| Alcohol Misuse and Kidney Injury: Epidemiological Evidence and Potential Mechanisms. | Varga ZV et al. | β | 2017 | β |
| Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARΞ±-mediated lipogenic gene expression. | Wang F et al. | β | 2017 | β |
| A systematic evaluation of microRNAs in regulating human hepatic CYP2E1. | Wang Y et al. | β | 2017 | β |
| Baicalin Ameliorates Liver Injury Induced by Chronic plus Binge Ethanol Feeding by Modulating Oxidative Stress and Inflammation via CYP2E1 and NRF2 in Mice. | He P et al. | β | 2017 | β |
| Biological implications of selenium in adolescent rats exposed to binge drinking: Oxidative, immunologic and apoptotic balance. | Ojeda ML et al. | β | 2017 | β |
| CYP2E1 regulates the development of radiation-induced pulmonary fibrosis via ER stress- and ROS-dependent mechanisms. | Son B et al. | β | 2017 | β |
| Direct Molecular Fishing of New Protein Partners for Human Thromboxane Synthase. | Svirid AV et al. | β | 2017 | β |
| Docosahexaenoic acid attenuates carbon tetrachloride-induced hepatic fibrosis in rats. | He J et al. | β | 2017 | β |
| Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice. | MΓΌller MF et al. | β | 2017 | β |
| Ginsenosides from stems and leaves of ginseng prevent ethanol-induced lipid accumulation in human L02 hepatocytes. | Hu CF et al. | β | 2017 | β |
| Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications. | Nelson LJ et al. | β | 2017 | β |
| <i>In vitro</i> and <i>in vivo</i> antioxidative and hepatoprotective activity of aqueous extract of Cortex Dictamni. | Li L et al. | β | 2017 | β |
| Increased oxidative stress and deficient antioxidant levels may be involved in the pathogenesis of idiopathic recurrent acute pancreatitis. | Bopanna S et al. | β | 2017 | β |
| Inhibition of aldose reductase ameliorates alcoholic liver disease by activating AMPK and modulating oxidative stress and inflammatory cytokines. | Shi C et al. | β | 2017 | β |
| Kinetic characterizations of diallyl sulfide analogs for their novel role as CYP2E1 enzyme inhibitors. | Rahman MA et al. | β | 2017 | β |
| Malondialdehyde-acetaldehyde (MAA) adducted surfactant protein induced lung inflammation is mediated through scavenger receptor a (SR-A1). | Sapkota M et al. | β | 2017 | β |
| Mice lacking liver-specific Ξ²-catenin develop steatohepatitis and fibrosis after iron overload. | Preziosi ME et al. | β | 2017 | β |
| Oxidative stress and cellular and tissue damage in organogenic outbred mouse embryos after moderate perigestational alcohol intake. | Coll TA et al. | β | 2017 | β |
| Oxidative stress, a trigger of hepatitis C and B virus-induced liver carcinogenesis. | Ivanov AV et al. | β | 2017 | β |
| Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice. | Jiang Z et al. | β | 2017 | β |
| Protective Effects of Diallyl Sulfide Against Ethanol-Induced Injury in Rat Adipose Tissue and Primary Human Adipocytes. | Kema VH et al. | β | 2017 | β |
| Quercetin prevents type 1 diabetic liver damage through inhibition of CYP2E1. | Maksymchuk O et al. | β | 2017 | β |
| Repeated administration of ethambutol in therapeutic dose causes testes alteration and spermatogenesis disruption in Wistar rats. | Shayakhmetova GM et al. | β | 2017 | β |
| Role of CYP2E1 in Mitochondrial Dysfunction and Hepatic Injury by Alcohol and Non-Alcoholic Substances. | Abdelmegeed MA et al. | β | 2017 | β |
| The Role of CYP2E1 in the Drug Metabolism or Bioactivation in the Brain. | GarcΓa-SuΓ‘stegui WA et al. | β | 2017 | β |
| The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. | Xu J et al. | β | 2017 | β |
| Transcriptional profiling of male F344 rats suggests the involvement of calcium signaling in the mode of action of acrylamide-induced thyroid cancer. | Chepelev NL et al. | β | 2017 | β |
| Alcohol Upregulation of CYP2A5: Role of Reactive Oxygen Species. | Lu Y et al. | β | 2016 | β |
| A Mechanistic Review of Cell Death in Alcohol-Induced Liver Injury. | Wang S et al. | β | 2016 | β |
| AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550. | Joo MS et al. | β | 2016 | β |
| An improved in vitro method for screening toxin and medicine targeting CYP2E1. | Wang M et al. | β | 2016 | β |
| Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9. | Yauk CL et al. | β | 2016 | β |
| Changing phenotype and disease behaviour of chronic pancreatitis in India: evidence for gene-environment interactions. | Garg PK et al. | β | 2016 | β |
| Characterization of novel cytochrome P450 2E1 knockout rat model generated by CRISPR/Cas9. | Wang X et al. | β | 2016 | β |
| Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway. | Chen Y et al. | β | 2016 | β |
| Critical Roles of Kupffer Cells in the Pathogenesis of Alcoholic Liver Disease: From Basic Science to Clinical Trials. | Zeng T et al. | β | 2016 | β |
| Decreased hepatic iron in response to alcohol may contribute to alcohol-induced suppression of hepcidin. | Varghese J et al. | β | 2016 | β |
| Defect of mitochondrial respiratory chain is a mechanism of ROS overproduction in a rat model of alcoholic liver disease: role of zinc deficiency. | Sun Q et al. | β | 2016 | β |
| Dietary Fisetin Supplementation Protects Against Alcohol-Induced Liver Injury in Mice. | Sun Q et al. | β | 2016 | β |
| Differential contribution of complement receptor C5aR in myeloid and non-myeloid cells in chronic ethanol-induced liver injury in mice. | McCullough RL et al. | β | 2016 | β |
| Effects of Linderae radix extracts on a rat model of alcoholic liver injury. | Wang JW et al. | β | 2016 | β |
| Effects of soy containing diet and isoflavones on cytochrome P450 enzyme expression and activity. | Ronis MJ | β | 2016 | β |
| Ephedra water decoction and cough tablets containing ephedra and liquorice induce CYP1A2 but not CYP2E1 hepatic enzymes in rats. | Tang J et al. | β | 2016 | β |
| Gender differences in murine pulmonary responses elicited by cellulose nanocrystals. | Shvedova AA et al. | β | 2016 | β |
| Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1. | Smirnova OA et al. | β | 2016 | β |
| Ligularia fischeri extract attenuates liver damage induced by chronic alcohol intake. | Kim D et al. | β | 2016 | β |
| Linking Pathogenic Mechanisms of Alcoholic Liver Disease WithΒ Clinical Phenotypes. | Nagy LE et al. | β | 2016 | β |
| Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets. | Zhang CY et al. | β | 2016 | β |
| Lupane-type triterpenes and their anti-cancer activities against most common malignant tumors: A review. | ChΓ‘irez-RamΓrez MH et al. | β | 2016 | β |
| Moderate (2%, v/v) Ethanol Feeding Alters Hepatic Wound Healing after Acute Carbon Tetrachloride Exposure in Mice. | Deshpande KT et al. | β | 2016 | β |
| Oxidative Stress in the Healthy and Wounded Hepatocyte: A Cellular Organelles Perspective. | Mello T et al. | β | 2016 | β |
| Protective effect of Cistanchis A on ethanol-induced damage in primary cultured mouse hepatocytes. | Luo H et al. | β | 2016 | β |
| Protective effect of PyropiaΒ yezoensis glycoprotein on chronic ethanol consumption-induced hepatotoxicity in rats. | Choi JW et al. | β | 2016 | β |
| Protective Effect of Tyrosol and S-Adenosylmethionine against Ethanol-Induced Oxidative Stress of Hepg2 Cells Involves Sirtuin 1, P53 and Erk1/2 Signaling. | Stiuso P et al. | β | 2016 | β |
| Roles of CYP2e1 in 1,2-dichloroethane-induced liver damage in mice. | Sun Q et al. | β | 2016 | β |
| Roles of defective ALDH2 polymorphism on liver protection and cancer development. | Matsumoto A et al. | β | 2016 | β |
| The Benefits of Administering Folic Acid in Order to Combat the Oxidative Damage Caused by Binge Drinking in Adolescent Rats. | Ojeda ML et al. | β | 2016 | β |
| The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference. | Hong F et al. | β | 2016 | β |
| Tlr4-mutant mice are resistant to acute alcohol-induced sterol-regulatory element binding protein activation and hepatic lipid accumulation. | Zhang ZH et al. | β | 2016 | β |
| Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice. | Hong F et al. | β | 2015 | β |
| Alcoholic liver disease: mechanisms of injury and targeted treatment. | Louvet A et al. | β | 2015 | β |
| Alteration in the expression of cytochrome P450s (CYP1A1, CYP2E1, and CYP3A11) in the liver of mouse induced by microcystin-LR. | Zhang B et al. | β | 2015 | β |
| Anti-inflammatory and antioxidant effects of umbelliferone in chronic alcohol-fed rats. | Sim MO et al. | β | 2015 | β |
| Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity. | Lu Y et al. | β | 2015 | β |
| Binge Ethanol and MDMA Combination Exacerbates Toxic Cardiac Effects by Inducing Cellular Stress. | Navarro-Zaragoza J et al. | β | 2015 | β |
| Circadian rhythms, alcohol and gut interactions. | Forsyth CB et al. | β | 2015 | β |
| Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model. | Zhang P et al. | β | 2015 | β |
| Development of an Animal Model for Alcoholic Liver Disease in Zebrafish. | Lin JN et al. | β | 2015 | β |
| Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1. | Rao PS et al. | β | 2015 | β |
| Dietary saturated fatty acids reduce hepatic lipid accumulation but induce fibrotic change in alcohol-fed rats. | Chen YL et al. | β | 2015 | β |
| Effect of alcohol on adipose tissue: a review on ethanol mediated adipose tissue injury. | Kema VH et al. | β | 2015 | β |
| Effects of tetrahydroxystilbene glucoside on mouse liver cytochrome P450 enzyme expressions. | Wang YY et al. | β | 2015 | β |
| Effects of triterpenoid from Schisandra chinensis on oxidative stress in alcohol-induced liver injury in rats. | Li B et al. | β | 2015 | β |
| Establishment of the tree shrew as an alcohol-induced Fatty liver model for the study of alcoholic liver diseases. | Xing H et al. | β | 2015 | β |
| Ethanol at low concentrations protects glomerular podocytes through alcohol dehydrogenase and 20-HETE. | McCarthy ET et al. | β | 2015 | β |
| HCV core protein uses multiple mechanisms to induce oxidative stress in human hepatoma Huh7 cells. | Ivanov AV et al. | β | 2015 | β |
| Hepatobiliary Quiz (Answers)-15 (2015). | Rathi S et al. | β | 2015 | β |
| Hepatoprotective potential of Lavandula coronopifolia extracts against ethanol induced oxidative stress-mediated cytotoxicity in HepG2 cells. | Farshori NN et al. | β | 2015 | β |
| Inflammatory PAF Receptor Signaling Initiates Hedgehog Signaling and Kidney Fibrogenesis During Ethanol Consumption. | Latchoumycandane C et al. | β | 2015 | β |
| Inhibition of Hepatocyte Apoptosis: An Important Mechanism of Corn Peptides Attenuating Liver Injury Induced by Ethanol. | Ma Z et al. | β | 2015 | β |
| Interleukin-32Ξ³ attenuates ethanol-induced liver injury by the inhibition of cytochrome P450 2E1 expression and inflammatory responses. | Lee DH et al. | β | 2015 | β |
| Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/Sirt1 activation. | Han JY et al. | β | 2015 | β |
| Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease. | Tebay LE et al. | β | 2015 | β |
| Metabolic methanol: molecular pathways and physiological roles. | Dorokhov YL et al. | β | 2015 | β |
| Myeloperoxidase formation of PAF receptor ligands induces PAF receptor-dependent kidney injury during ethanol consumption. | Latchoumycandane C et al. | β | 2015 | β |
| Novel insights into the mechanisms whereby isoflavones protect against fatty liver disease. | Qiu LX et al. | β | 2015 | β |
| Role of Kupffer cells in ischemic injury in alcoholic fatty liver. | Park SW et al. | β | 2015 | β |
| Sweet grass protection against oxidative stress formation in the rat brain. | Εuczaj W et al. | β | 2015 | β |
| Transgenic mouse models for alcohol metabolism, toxicity, and cancer. | Heit C et al. | β | 2015 | β |
| Use of metabolomics to elucidate the metabolic perturbation associated with hypertension in a black South African male cohort: the SABPA study. | van Deventer CA et al. | β | 2015 | β |
| Vitamin paradox in obesity: Deficiency or excess? | Zhou SS et al. | β | 2015 | β |
| Xenobiotic and Endobiotic Mediated Interactions Between the Cytochrome P450 System and the Inflammatory Response in the Liver. | Woolbright BL et al. | β | 2015 | β |
| Antioxidant properties of jujube honey and its protective effects against chronic alcohol-induced liver damage in mice. | Cheng N et al. | β | 2014 | β |
| Autophagy in alcohol-induced multiorgan injury: mechanisms and potential therapeutic targets. | Li Y et al. | β | 2014 | β |
| Berberine protects liver from ethanol-induced oxidative stress and steatosis in mice. | Zhang P et al. | β | 2014 | β |
| Binge alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-induced simple steatosis. | Minato T et al. | β | 2014 | β |
| Binge alcohol promotes hypoxic liver injury through a CYP2E1-HIF-1Ξ±-dependent apoptosis pathway in mice and humans. | Yun JW et al. | β | 2014 | β |
| Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan. | Jackson AF et al. | β | 2014 | β |
| Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model. | Kim HG et al. | β | 2014 | β |
| CYP2E1 autoantibodies in liver diseases. | Sutti S et al. | β | 2014 | β |
| CYP2E1 induction leads to oxidative stress and cytotoxicity in glutathione-depleted cerebellar granule neurons. | Valencia-Olvera AC et al. | β | 2014 | β |
| Dysregulation of hepatic zinc transporters in a mouse model of alcoholic liver disease. | Sun Q et al. | β | 2014 | β |
| Farnesoid X receptor regulates forkhead BoxΒ O3a activation in ethanol-induced autophagy and hepatotoxicity. | Manley S et al. | β | 2014 | β |
| Functional roles of protein nitration in acute and chronic liver diseases. | Abdelmegeed MA et al. | β | 2014 | β |
| Hepatoprotective effects of fermented Curcuma longa L. on carbon tetrachloride-induced oxidative stress in rats. | Kim Y et al. | β | 2014 | β |
| Human placental lactogen induces CYP2E1 expression via PI 3-kinase pathway in female human hepatocytes. | Lee JK et al. | β | 2014 | β |
| Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness. | Forsyth CB et al. | β | 2014 | β |
| Leukocyte activity in patients with ST-segment elevation acute myocardial infarction treated with anakinra. | Sonnino C et al. | β | 2014 | β |
| Neurotoxicity and gene-expressed profile in brain-injured mice caused by exposure to titanium dioxide nanoparticles. | Ze Y et al. | β | 2014 | β |
| Oleanolic acid co-administration alleviates ethanol-induced hepatic injury via Nrf-2 and ethanol-metabolizing modulating in rats. | Liu J et al. | β | 2014 | β |
| Pathogenesis of alcoholic liver disease: role of oxidative metabolism. | Ceni E et al. | β | 2014 | β |
| Pre-endurance training prevents acute alcoholic liver injury in rats through the regulation of damaged mitochondria accumulation and mitophagy balance. | Ma GD et al. | β | 2014 | β |
| Protective effect of flavonoid extract from Chinese bayberry (Myrica rubra Sieb. et Zucc.) fruit on alcoholic liver oxidative injury in mice. | Liu H et al. | β | 2014 | β |
| Protective effects of dioscin against alcohol-induced liver injury. | Xu T et al. | β | 2014 | β |
| Role and importance of polymorphisms with respect to DNA methylation for the expression of CYP2E1 enzyme. | Naselli F et al. | β | 2014 | β |
| Sorghum-based alcoholic beverage, Burukutu, perturbs the redox status of the liver of male rats. | Ajiboye TO et al. | β | 2014 | β |
| Taurine and liver diseases: a focus on the heterogeneous protective properties of taurine. | Miyazaki T et al. | β | 2014 | β |
| The role of oxidative stress in the development of alcoholic liver disease. | Galicia-Moreno M et al. | β | 2014 | β |
| Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway. | Xiao J et al. | β | 2014 | β |
| Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease. | Hayashi N et al. | β | 2013 | β |
| Alcohol dehydrogenase and cytochrome P450 2E1 can be induced by long-term exposure to ethanol in cultured liver HEP-G2 cells. | Balusikova K et al. | β | 2013 | β |
| [Alcoholic and non-alcoholic steatohepatitis: who is affected and what can we do for them?]. | Gallego-DurΓ‘n R et al. | β | 2013 | β |
| Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress. | Singh S et al. | β | 2013 | β |
| Bermuda Triangle for the liver: alcohol, obesity, and viral hepatitis. | Zakhari S | β | 2013 | β |
| Circadian disruption: potential implications in inflammatory and metabolic diseases associated with alcohol. | Voigt RM et al. | β | 2013 | β |
| CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease. | Leung TM et al. | β | 2013 | β |
| Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells. | Leung T et al. | β | 2013 | β |
| Cytochrome P4502E1 inhibitor, chlormethiazole, decreases lipopolysaccharide-induced inflammation in rat Kupffer cells with ethanol treatment. | Ye Q et al. | β | 2013 | β |
| Cytochrome P450 2E1: its clinical aspects and a brief perspective on the current research scenario. | Dey A | β | 2013 | β |
| Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1Ξ± in vivo. | Wang X et al. | β | 2013 | β |
| Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. | Zanger UM et al. | β | 2013 | β |
| Differences in the expression and sensitivity of cultured rat brain neuronal and glial cells toward the monocrotophos. | Tripathi VK et al. | β | 2013 | β |
| Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer. | Hakenewerth AM et al. | β | 2013 | β |
| Effects of the extracts and an active compound curcumenone isolated from Curcuma zedoaria rhizomes on alcohol-induced drunkenness in mice. | Kimura Y et al. | β | 2013 | β |
| Estrogen-related receptor Ξ³ controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol. | Kim DK et al. | β | 2013 | β |
| Ethanol potentiates hepatitis B virus replication through oxidative stress-dependent and -independent transcriptional activation. | Min BY et al. | β | 2013 | β |
| Evaluation of genetic polymorphisms in patients with multiple chemical sensitivity. | Cui X et al. | β | 2013 | β |
| HCV and oxidative stress in the liver. | Ivanov AV et al. | β | 2013 | β |
| Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models. | Bansal S et al. | β | 2013 | β |
| Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis. | Shearn CT et al. | β | 2013 | β |
| Influence of aging on ethanol-induced oxidative stress in digestive tract of rats. | VuceviΔ D et al. | β | 2013 | β |
| Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK. | Wu D et al. | β | 2013 | β |
| Involvement of free radicals and oxidative stress in NAFLD/NASH. | Sumida Y et al. | β | 2013 | β |
| Metabolomics of ginger essential oil against alcoholic fatty liver in mice. | Liu CT et al. | β | 2013 | β |
| microRNAs as mediators of drug toxicity. | Yokoi T et al. | β | 2013 | β |
| Nicotine enhances ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse liver. | Lu Y et al. | β | 2013 | β |
| Nrf2 and antioxidant defense against CYP2E1 toxicity. | Cederbaum AI | β | 2013 | β |
| Polymorphisms in the human cytochrome P450 and arylamine N-acetyltransferase: susceptibility to head and neck cancers. | Khlifi R et al. | β | 2013 | β |
| Pregnancy and pharmacogenomics in the context of drug metabolism and response. | HelldΓ©n A et al. | β | 2013 | β |
| Protective effect of Aplysin on hepatic injury in ethanol-treated rats. | Ge N et al. | β | 2013 | β |
| Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity via depleting heme pool and releasing CO. | Tang Y et al. | β | 2013 | β |
| Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. | Jin M et al. | β | 2013 | β |
| Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability. | Forsyth CB et al. | β | 2013 | β |
| Roles of cytochrome P4502E1 gene polymorphisms and the risks of alcoholic liver disease: a meta-analysis. | Zeng T et al. | β | 2013 | β |
| STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease. | Petrasek J et al. | β | 2013 | β |
| The activation of HO-1/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stress. | Zeng T et al. | β | 2013 | β |
| Agrimonia eupatoria protects against chronic ethanol-induced liver injury in rats. | Yoon SJ et al. | β | 2012 | β |
| Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytes. | Howarth DL et al. | β | 2012 | β |
| Alcohol metabolism. | Cederbaum AI | β | 2012 | β |
| Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy. | Wu D et al. | β | 2012 | β |
| A proteomic analysis of liver after ethanol binge in chronically ethanol treated rats. | Aroor AR et al. | β | 2012 | β |
| Bio-informatics based analysis of genes implicated in alcohol mediated liver injury. | Jagannathan L et al. | β | 2012 | β |
| Calcium-dependent physiologic and pathologic stimulus-metabolic response coupling in hepatocytes. | Gaspers LD et al. | β | 2012 | β |
| Chronic pancreatitis in India and Asia. | Garg PK | β | 2012 | β |
| Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model. | Gong WH et al. | β | 2012 | β |
| Cytochrome P450 2E1 variable number tandem repeat polymorphisms and health risks: a genotype-phenotype study in cancers associated with drinking and/or smoking. | Catanzaro I et al. | β | 2012 | β |
| Cytokines in alcoholic liver disease. | An L et al. | β | 2012 | β |
| Effects of ethanol on CYP2E1 levels and related oxidative stress using a standard balanced diet. | Azzalis LA et al. | β | 2012 | β |
| Effects of L-carnitine against oxidative stress in human hepatocytes: involvement of peroxisome proliferator-activated receptor alpha. | Li JL et al. | β | 2012 | β |
| Ethanol-induced oxidative stress via the CYP2E1 pathway disrupts adiponectin secretion from adipocytes. | Tang H et al. | β | 2012 | β |
| Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. | Lu Y et al. | β | 2012 | β |
| Ethanol suppresses ureagenesis in rat hepatocytes: role of acetaldehyde. | Holmuhamedov EL et al. | β | 2012 | β |
| Genes encoding enzymes involved in ethanol metabolism. | Hurley TD et al. | β | 2012 | β |
| Genetic polymorphisms of genes coding to alcohol-metabolizing enzymes in western Mexicans: association of CYP2E1*c2/CYP2E1*5B allele with cirrhosis and liver function. | GarcΓa-BaΓ±uelos J et al. | β | 2012 | β |
| In vitro evidence for chronic alcohol and high glucose mediated increased oxidative stress and hepatotoxicity. | Chandrasekaran K et al. | β | 2012 | β |
| K(Ca)2 channels: novel therapeutic targets for treating alcohol withdrawal and escalation of alcohol consumption. | Mulholland PJ | β | 2012 | β |
| Liver cancer and alcohol. | Grewal P et al. | β | 2012 | β |
| Oxidative stress and inflammation: essential partners in alcoholic liver disease. | Ambade A et al. | β | 2012 | β |
| Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury. | Bae SH et al. | β | 2012 | β |
| Phosphoenolpyruvic acid, an intermediary metabolite of glycolysis, as a potential cytoprotectant and anti-oxidant in HeLa cells. | Kondo Y et al. | β | 2012 | β |
| Potential in vitro Protective Effect of Quercetin, Catechin, Caffeic Acid and Phytic Acid against Ethanol-Induced Oxidative Stress in SK-Hep-1 Cells. | Lee KM et al. | β | 2012 | β |
| Regulation of mitochondrial function by voltage dependent anion channels in ethanol metabolism and the Warburg effect. | Lemasters JJ et al. | β | 2012 | β |
| Rodent models of alcoholic liver disease: of mice and men. | Brandon-Warner E et al. | β | 2012 | β |
| The effects of cold-induced stress on liver oxidative injury during binge drinking. | OstojiΔ JN et al. | β | 2012 | β |
| Alcohol induces liver neoplasia in a novel alcohol-preferring rat model. | Yip-Schneider MT et al. | β | 2011 | β |
| Caffeic acid inhibits the formation of 1-hydroxyethyl radical in the reaction mixture of rat liver microsomes with ethanol partly through its metal chelating activity. | Ikeda H et al. | β | 2011 | β |
| Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells. | Jeannot E et al. | β | 2011 | β |
| Co-treatment with Shengmai San-derived herbal product ameliorates chronic ethanol-induced liver damage in rats. | Chiu PY et al. | β | 2011 | β |
| Discovery of serum biomarkers of alcoholic fatty liver in a rodent model: C-reactive protein. | Liu SL et al. | β | 2011 | β |
| Drug metabolism alterations in nonalcoholic fatty liver disease. | Merrell MD et al. | β | 2011 | β |
| Effect of alcohol on drug efflux protein and drug metabolic enzymes in U937 macrophages. | Jin M et al. | β | 2011 | β |
| Ethanol, acetaldehyde, and estradiol affect growth and differentiation of rhesus monkey embryonic stem cells. | VandeVoort CA et al. | β | 2011 | β |
| Ethanol induction of CYP2A5: permissive role for CYP2E1. | Lu Y et al. | β | 2011 | β |
| Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice. | Sebastian BM et al. | β | 2011 | β |
| In vitro inhibition of porcine cytochrome P450 by 17Ξ² -estradiol and 17Ξ±-estradiol. | Zamaratskaia G et al. | β | 2011 | β |
| Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in mice. | Li S et al. | β | 2011 | β |
| Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis. | Chacko BK et al. | β | 2011 | β |
| Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress. | Zhang J et al. | β | 2011 | β |
| Progression of alcoholic and non-alcoholic steatohepatitis: common metabolic aspects of innate immune system and oxidative stress. | Sakaguchi S et al. | β | 2011 | β |
| Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells. | Andreo U et al. | β | 2011 | β |
| Some enzymatic/nonenzymatic antioxidants as potential stress biomarkers of trichloroethylene, heavy metal mixture, and ethyl alcohol in rat tissues. | Tabrez S et al. | β | 2011 | β |
| Stabilization of superoxide dismutase by acetyl-l-carnitine in human brain endothelium during alcohol exposure: novel protective approach. | Haorah J et al. | β | 2011 | β |
| Survival rates of early-stage HCV-related liver cirrhosis patients without hepatocellular carcinoma are decreased by alcohol. | Yamada M et al. | β | 2011 | β |
| The inflammatory footprints of alcohol-induced oxidative damage in neurovascular components. | Alikunju S et al. | β | 2011 | β |
| Toxicological implications of modulation of gene expression by microRNAs. | Yokoi T et al. | β | 2011 | β |
| Acetaldehyde adducts in alcoholic liver disease. | Setshedi M et al. | β | 2010 | β |
| Activation of ASK-1 and downstream MAP kinases in cytochrome P4502E1 potentiated tumor necrosis factor alpha liver injury. | Wu D et al. | β | 2010 | β |
| Aquaporin-4 knockout enhances astrocyte toxicity induced by 1-methyl-4-phenylpyridinium ion and lipopolysaccharide via increasing the expression of cytochrome P4502E1. | Hao C et al. | β | 2010 | β |
| Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. | Ding WX et al. | β | 2010 | β |
| Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress. | Lv X et al. | β | 2010 | β |
| Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. | Lu Y et al. | β | 2010 | β |
| Conformational anti-cytochrome P4502E1 (CYP2E1) auto-antibodies contribute to necro-inflammatory injury in chronic hepatitis C. | Sutti S et al. | β | 2010 | β |
| CYP2E1 potentiation of LPS and TNFΞ±-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction. | Lu Y et al. | β | 2010 | β |
| Effects of hepatic drug-metabolizing enzyme induction on clinical pathology parameters in animals and man. | Ennulat D et al. | β | 2010 | β |
| Ethanol-induced oxidative stress: basic knowledge. | Comporti M et al. | β | 2010 | β |
| Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicology. | Josephy PD | β | 2010 | β |
| Gentiana manshurica Kitagawa reverses acute alcohol-induced liver steatosis through blocking sterol regulatory element-binding protein-1 maturation. | Lian LH et al. | β | 2010 | β |
| Hepatocyte death: a clear and present danger. | Malhi H et al. | β | 2010 | β |
| Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells. | Yang H et al. | β | 2010 | β |
| Homology modeling and molecular dynamics of CYP1A1 and CYP2B1 to explore the metabolism of aryl derivatives by docking and experimental assays. | Rosales-HernΓ‘ndez MC et al. | β | 2010 | β |
| Human CYP2E1 is regulated by miR-378. | Mohri T et al. | β | 2010 | β |
| In vitro and in vivo hepatoprotective effects of the aqueous extract from Taraxacum officinale (dandelion) root against alcohol-induced oxidative stress. | You Y et al. | β | 2010 | β |
| Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. | Powell CL et al. | β | 2010 | β |
| Mechanisms of MDMA (ecstasy)-induced oxidative stress, mitochondrial dysfunction, and organ damage. | Song BJ et al. | β | 2010 | β |
| Molecular basis and current treatment for alcoholic liver disease. | Miranda-Mendez A et al. | β | 2010 | β |
| Paeonol, the main active principles of Paeonia moutan, ameliorates alcoholic steatohepatitis in mice. | Hu S et al. | β | 2010 | β |
| Pharmacogenetics of drug-induced liver injury. | Russmann S et al. | β | 2010 | β |
| Polymorphisms of alcohol metabolizing enzymes in indigenous Mexican population: unusual high frequency of CYP2E1*c2 allele. | Gordillo-Bastidas E et al. | β | 2010 | β |
| Protective Effect of Emblica officinalis Against Alcohol-Induced Hepatic Injury by Ameliorating Oxidative Stress in Rats. | Damodara Reddy V et al. | β | 2010 | β |
| Protective effect of Phyllanthus niruri on alcohol and heated sunflower oil induced hyperlipidemia in Wistar rats. | Latha P et al. | β | 2010 | β |
| Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma. | Brandon-Warner E et al. | β | 2010 | β |
| Structural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR. | Gay SC et al. | β | 2010 | β |
| The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat. | Ronis MJ et al. | β | 2010 | β |
| The role of NOX enzymes in ethanol-induced oxidative stress and apoptosis in mouse embryos. | Dong J et al. | β | 2010 | β |
| A randomized controlled trial of antioxidant supplementation for pain relief in patients with chronic pancreatitis. | Bhardwaj P et al. | β | 2009 | β |
| Chlorzoxazone hydroxylation in microsomes and hepatocytes from cytochrome P450 oxidoreductase-null mice. | Li L et al. | β | 2009 | β |
| Chronic ethanol feeding affects proteasome-interacting proteins. | Bousquet-Dubouch MP et al. | β | 2009 | β |
| CYP1A2*1C, CYP2E1*5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients. | Olivieri EH et al. | β | 2009 | β |
| Ethanol-induced liver injury and changes in sulfur amino acid metabolomics in glutathione peroxidase and catalase double knockout mice. | Kim SJ et al. | β | 2009 | β |
| Formation of gamma-ketoaldehyde-protein adducts during ethanol-induced liver injury in mice. | Roychowdhury S et al. | β | 2009 | β |
| Fructose and carbonyl metabolites as endogenous toxins. | Lee O et al. | β | 2009 | β |
| Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity. | Vinken M et al. | β | 2009 | β |
| Hepatocyte growth factor protects hepatocytes against oxidative injury induced by ethanol metabolism. | ValdΓ©s-Arzate A et al. | β | 2009 | β |
| Hepatocyte inflammation model for cytotoxicity research: fructose or glycolaldehyde as a source of endogenous toxins. | Feng CY et al. | β | 2009 | β |
| Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice. | Zhuge J et al. | β | 2009 | β |
| Metabolism of ethanol to acetaldehyde and increased susceptibility to oxidative stress could play a role in the ovarian tissue cell injury promoted by alcohol drinking. | Faut M et al. | β | 2009 | β |
| Nrf2 and antioxidant defense against CYP2E1 toxicity. | Cederbaum A | β | 2009 | β |
| PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease. | Hardwick JP et al. | β | 2009 | β |
| Protective effects of saponins from the root of Platycodon grandiflorum against fatty liver in chronic ethanol feeding via the activation of AMP-dependent protein kinase. | Khanal T et al. | β | 2009 | β |
| Role of free radicals in liver diseases. | Muriel P | β | 2009 | β |
| Saponins isolated from the root of Platycodon grandiflorum protect against acute ethanol-induced hepatotoxicity in mice. | Khanal T et al. | β | 2009 | β |
| Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of alpha-tocopherol deficient mice. | Vasu VT et al. | β | 2009 | β |
| The double danger of ethanol and hypoxia: their effects on a hepatoma cell line. | Wang SM et al. | β | 2009 | β |
| The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model. | Butura A et al. | β | 2009 | β |
| The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. | Mandrekar P et al. | β | 2009 | β |
| Vitamin E supplementation does not prevent ethanol-reduced hepatic retinoic acid levels in rats. | Chung J et al. | β | 2009 | β |
| Alcohol and the liver. | Reuben A | β | 2008 | β |
| Deleterious effects induced by oxidative stress in liver nuclei from rats receiving an alcohol-containing liquid diet. | DΓaz GΓ³mez MI et al. | β | 2008 | β |
| Mechanism of alcohol-induced oxidative stress and neuronal injury. | Haorah J et al. | β | 2008 | β |
| New concepts in the pathogenesis of alcoholic liver disease. | Albano E | β | 2008 | β |
| Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates. | Porubsky PR et al. | β | 2008 | β |