Genetic research and health disparities.
paper
Cited
Public
Unavailable
- Authors
- Sankar, Pamela; Cho, Mildred K; Condit, Celeste M; Hunt, Linda M; Koenig, Barbara; Marshall, Patricia; Lee, Sandra Soo-Jin; Spicer, Paul
- Year
- 2004
- Journal
- JAMA
- PMID
- 15213210
- DOI
- 10.1001/jama.291.24.2985
- PMCID
- PMC2271142
Alleviating health disparities in the United States is a goal with broad support. Medical research undertaken to achieve this goal typically adopts the well-established perspective that racial discrimination and poverty are the major contributors to unequal health status. However, the suggestion is increasingly made that genetic research also has a significant role to play in alleviating this problem, which likely overstates the importance of genetics as a factor in health disparities. Overemphasis on genetics as a major explanatory factor in health disparities could lead researchers to miss factors that contribute to disparities more substantially and may also reinforce racial stereotyping, which may contribute to disparities in the first place. Arguments that promote genetics research as a way to help alleviate health disparities are augmented by several factors, including research funding initiatives and the distinct demographic patterns of health disparities in the United States.
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|---|---|---|---|---|
| African Genetic Ancestry, Structural and Social Determinants of Health, and Mortality in Black Adults. | Iyer HS et al. | — | 2025 | → |
| Breaking research silos to achieve equitable precision medicine in rheumatology. | Ainsworth HC et al. | — | 2025 | → |
| Disparities in disease presentation among patients with papillary thyroid cancer: A retrospective cohort study. | Rodriguez N et al. | — | 2025 | → |
| Prevalence and Clinical Characteristics of Vasculitis in the Alaska Native and American Indian Peoples of Alaska. | Henderson BA et al. | — | 2025 | → |
| Rethinking ethnicity data for precision health. | Poduval S et al. | — | 2025 | → |
| Stakeholder experiences and perspectives of genetic and genomic screening procedures in the Gulf Cooperation Council (GCC) region: a qualitative exploration. | Shaheen S et al. | — | 2025 | → |
| Addressing the research gap: access to care hinders genetic discovery in systemic lupus erythematosus patients throughout the African diaspora. | Hwang J et al. | — | 2024 | → |
| Aspiring toward equitable benefits from genomic advances to individuals of ancestrally diverse backgrounds. | Wang Y et al. | — | 2024 | → |
| Cross-disciplinary rapid scoping review of structural racial and caste discrimination associated with population health disparities in the 21<sup>st</sup>Century | Rasali DP et al. | — | 2024 | — |
| Racial Disparities in Sports Cardiology: A Review. | Krishnan S et al. | — | 2024 | → |
| Sociodemographic Disparities in HER2+ Breast Cancer Trastuzumab Receipt: An English Population-Based Study. | Norris RP et al. | — | 2024 | → |
| Age-based spatial disparities of COVID-19 incidence rates in the United States counties. | Huang Q | — | 2023 | → |
| Can lifestyle factors explain racial and ethnic inequalities in all-cause mortality among US adults? | Puka K et al. | — | 2023 | → |
| Health inequity in genomic personalized medicine in underrepresented populations: a look at the current evidence. | Tawfik SM et al. | — | 2023 | → |
| Latinx attitudes, barriers, and experiences with genetic counseling and testing: A systematic review. | Dron HA et al. | — | 2023 | → |
| Locking the Revolving Door: Racial Disparities in Cardiovascular Disease. | Velarde G et al. | — | 2023 | → |
| Obesity Stigma: Causes, Consequences, and Potential Solutions. | Westbury S et al. | — | 2023 | → |
| Sick individuals, sick populations revisited: a test of the Rose hypothesis for type 2 diabetes disparities. | Gupta S et al. | — | 2023 | → |
| A bibliometric review on the top 20 cited articles in the Jackson heart study. | Shareef MA et al. | — | 2022 | → |
| A lack of race and ethnicity data in the treatment of hereditary hemorrhagic telangiectasia: a systematic review of intravenous bevacizumab efficacy. | Galiatsatos P et al. | — | 2022 | → |
| Health equality, race and pharmacogenomics. | Magavern EF et al. | — | 2022 | → |
| Recommendations on the use and reporting of race, ethnicity, and ancestry in genetic research: Experiences from the NHLBI TOPMed program. | Khan AT et al. | — | 2022 | → |
| Structural Racial Discrimination and Structural Resilience: Measurement Precedes Change. | Szanton SL et al. | — | 2022 | → |
| The Challenge of Recruiting Diverse Populations into Health Research: An embedded social science perspective. | Outram SM et al. | — | 2022 | → |
| A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals. | Schaniel C et al. | — | 2021 | → |
| Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated. | Beach SRH et al. | — | 2021 | → |
| Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations. | Yang C et al. | — | 2021 | → |
| Increasing access to individualized medicine: a matched-cohort study examining Latino participant experiences of genomic screening. | Pacyna JE et al. | — | 2021 | → |
| Leveraging genetic ancestry to study health disparities. | Batai K et al. | — | 2021 | → |
| Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues. | Lewis ACF et al. | — | 2021 | → |
| The Role of Genetic Ancestry as a Risk Factor for Primary Open-angle Glaucoma in African Americans. | Cole BS et al. | — | 2021 | → |
| Applying Mental Model Methods to Characterize Understanding of Gene-Environment Influences: The Case of Podoconiosis in Ethiopia. | Allen CG et al. | — | 2019 | → |
| Understanding the potential of state-based public health genomics programs to mitigate disparities in access to clinical genetic services. | Senier L et al. | — | 2019 | → |
| Addressing racial bias in wards. | Tsai J et al. | — | 2018 | → |
| Assessment of health care, hospital admissions, and mortality by ethnicity: population-based cohort study of health-system performance in Scotland. | Katikireddi SV et al. | — | 2018 | → |
| Ethnic and population differences in the genetic predisposition to human obesity. | Stryjecki C et al. | — | 2018 | → |
| Genetic disease risks can be misestimated across global populations. | Kim MS et al. | — | 2018 | → |
| Prioritizing diversity in human genomics research. | Hindorff LA et al. | — | 2018 | → |
| Prognostic markers in well differentiated papillary and follicular thyroid cancer (WDTC). | Gillanders SL et al. | — | 2018 | → |
| Risk for spontaneous preterm birth among inter-racial/ethnic couples. | Shachar BZ et al. | — | 2018 | → |
| SAGE: a comprehensive resource of genetic variants integrating South Asian whole genomes and exomes. | Hariprakash JM et al. | — | 2018 | → |
| Sequencing Newborns: A Call for Nuanced Use of Genomic Technologies. | Johnston J et al. | — | 2018 | → |
| Barriers and Strategies Related to Qualitative Research on Genetic Ancestry Testing in Indigenous Communities. | Blanchard JW et al. | — | 2017 | → |
| Genomics, Health Disparities, and Missed Opportunities for the Nation's Research Agenda. | West KM et al. | — | 2017 | → |
| Photo-documentation in the community: reflections on genetics, health and health disparities. | Morello L et al. | — | 2017 | → |
| Precisely Where Are We Going? Charting the New Terrain of Precision Prevention. | Meagher KM et al. | — | 2017 | → |
| Precision Nutrition and Omega-3 Polyunsaturated Fatty Acids: A Case for Personalized Supplementation Approaches for the Prevention and Management of Human Diseases. | Chilton FH et al. | — | 2017 | → |
| Review: Genetic research on alcohol use outcomes in African American populations: A review of the literature, associated challenges, and implications. | Dick DM et al. | — | 2017 | → |
| Accelerated Health Declines among African Americans in the USA. | Thorpe RJ et al. | — | 2016 | → |
| Ethnic Classification in the New Zealand Health Care System. | Rata E et al. | — | 2016 | → |
| Examining the Presence, Consequences, and Reduction of Implicit Bias in Health Care: A Narrative Review. | Zestcott CA et al. | — | 2016 | → |
| From "Personalized" to "Precision" Medicine: The Ethical and Social Implications of Rhetorical Reform in Genomic Medicine. | Juengst E et al. | — | 2016 | → |
| Precision medicine: opportunities, possibilities, and challenges for patients and providers. | Adams SA et al. | — | 2016 | → |
| Race Matters? Examining and Rethinking Race Portrayal in Preclinical Medical Education. | Tsai J et al. | — | 2016 | → |
| Ethical, legal and social implications of incorporating personalized medicine into healthcare. | Brothers KB et al. | — | 2015 | → |
| Genomics in research and health care with Aboriginal and Torres Strait Islander peoples. | McWhirter R et al. | — | 2015 | → |
| Mapping the Ethics of Translational Genomics: Situating Return of Results and Navigating the Research-Clinical Divide. | Wolf SM et al. | — | 2015 | → |
| Prevalence and Severity of Symptoms in a Sample of African Americans and White Participants. | Taneja I et al. | — | 2015 | → |
| Sedentary behavior and prevalent diabetes in Non-Latino Whites, Non-Latino Blacks and Latinos: findings from the National Health Interview Survey. | Larsen BA et al. | — | 2015 | → |
| Self-reported race/ethnicity in the age of genomic research: its potential impact on understanding health disparities. | Mersha TB et al. | — | 2015 | → |
| Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. | Chilton FH et al. | — | 2014 | → |
| Emerging issues in public health genomics. | Roberts JS et al. | — | 2014 | → |
| Perceptions of African-American health professionals and community members on the participation of children and pregnant women in genetic research. | Ngui EM et al. | — | 2014 | → |
| Racial and socioeconomic disparities in presentation and outcomes of well-differentiated thyroid cancer. | Harari A et al. | — | 2014 | → |
| The public health exposome: a population-based, exposure science approach to health disparities research. | Juarez PD et al. | — | 2014 | → |
| Advancing genomic research and reducing health disparities: what can nurse scholars do? | Jaja C et al. | — | 2013 | → |
| Defining race/ethnicity and explaining difference in research studies on lung function. | Braun L et al. | — | 2013 | → |
| Ethical issues in pediatric pharmacogenomics. | Brothers KB | — | 2013 | → |
| Gene-environment interactions and health inequalities: views of underserved communities. | Goldenberg AJ et al. | — | 2013 | → |
| Genome science and health disparities: a growing success story? | Rotimi C et al. | — | 2013 | → |
| Surrogate consent for genetic testing, the reconsent process, and consent for long-term outcomes in acute respiratory distress syndrome trials. | Smart A et al. | — | 2013 | → |
| The effects of race, ethnicity, and mood/anxiety disorders on the chronic physical health conditions of men from a national sample. | Johnson-Lawrence V et al. | — | 2013 | → |
| A study of national physician organizations' efforts to reduce racial and ethnic health disparities in the United States. | Peek ME et al. | — | 2012 | → |
| Estimating the contribution of genetic variants to difference in incidence of disease between population groups. | Moonesinghe R et al. | — | 2012 | → |
| Finding a place for genomics in health disparities research. | Fullerton SM et al. | — | 2012 | → |
| Genome-wide approaches in pharmacogenomics: heritability estimation and pharmacoethnicity as primary challenges. | Gamazon ER et al. | — | 2012 | → |
| Individual breast cancer risk assessment in underserved populations: integrating empirical bioethics and health disparities research. | Anderson EE et al. | — | 2012 | → |
| Management of AIDS-associated Kaposi's sarcoma in Nigerian children: a case series and review of literature. | Ahmed A et al. | — | 2012 | → |
| Non-hispanic whites have higher risk for pulmonary impairment from pulmonary tuberculosis. | Pasipanodya JG et al. | — | 2012 | → |
| Psychoneuroimmunology in pregnancy: immune pathways linking stress with maternal health, adverse birth outcomes, and fetal development. | Christian LM | — | 2012 | → |
| Racial/ethnic health disparities and ethics -- the need for a multilevel approach. | Brody H et al. | — | 2012 | → |
| The evolution and development of human social systems requires more than parasite-stress avoidance explanation. | Grotuss J | — | 2012 | → |
| A critical review of racial/ethnic variables in osteoporosis and bone density research. | Megyesi MS et al. | — | 2011 | → |
| Charting a course for genomic medicine from base pairs to bedside. | Green ED et al. | — | 2011 | → |
| Complex systems thinking and current impasses in health disparities research. | Diez Roux AV | — | 2011 | → |
| Factors associated with attributions about child health conditions and social distance preference. | Mukolo A et al. | — | 2011 | → |
| Interactions among genes, tumor biology and the environment in cancer health disparities: examining the evidence on a national and global scale. | Wallace TA et al. | — | 2011 | → |
| Patient perspectives on group benefits and harms in genetic research. | Goldenberg AJ et al. | — | 2011 | → |
| The racial disparity in breast cancer mortality. | Whitman S et al. | — | 2011 | → |
| The use of race, ethnicity and ancestry in human genetic research. | Ali-Khan SE et al. | — | 2011 | → |
| Ancestry and disease in the age of genomic medicine. | Rotimi CN et al. | — | 2010 | → |
| Collection of data on patients' race and ethnic group by physician practices. | Wynia MK et al. | — | 2010 | → |
| Disparidad en Salud: Un Fenómeno Multidimensional. | Urrutia MT et al. | — | 2010 | → |
| Exploring genetic susceptibility to cancer in diverse populations. | Haiman CA et al. | — | 2010 | → |
| Asking the right questions: views on genetic variation research among black and white research participants. | Bussey-Jones J et al. | — | 2009 | → |
| Community-based dialogue: engaging communities of color in the United states' genetics policy conversation. | Bonham VL et al. | — | 2009 | → |
| Functions of health fatalism: fatalistic talk as face saving, uncertainty management, stress relief and sense making. | Keeley B et al. | — | 2009 | → |
| Genetic ancestry, social classification, and racial inequalities in blood pressure in Southeastern Puerto Rico. | Gravlee CC et al. | — | 2009 | → |
| Hereditary breast and ovarian cancer syndrome : the impact of race on uptake of genetic counseling and testing. | Simon MS et al. | — | 2009 | → |
| Imaging genetics and the power of combined technologies: a perspective from neuroethics. | Tairyan K et al. | — | 2009 | → |
| Physicians' attitudes toward race, genetics, and clinical medicine. | Bonham VL et al. | — | 2009 | → |
| Race and ancestry in biomedical research: exploring the challenges. | Caulfield T et al. | — | 2009 | → |
| Race reconciled?: How biological anthropologists view human variation. | Edgar HJ et al. | — | 2009 | → |
| Racial and ethnic differences in willingness to participate in psychiatric genetic research. | Murphy EJ et al. | — | 2009 | → |
| The global pattern of gene identity variation reveals a history of long-range migrations, bottlenecks, and local mate exchange: implications for biological race. | Hunley KL et al. | — | 2009 | → |
| The Politics of the Gene: Social Status and Beliefs about Genetics for Individual Outcomes. | Shostak S et al. | — | 2009 | → |
| Conceptualizing race in research. | Corbie-Smith G et al. | — | 2008 | → |
| Cumulative burden of atherosclerotic risk genotypes and the age at onset of a first myocardial infarction: a case-only carriership approach. | Goldenberg I et al. | — | 2008 | → |
| Family physicians' beliefs about genetic contributions to racial/ethnic and gender differences in health and clinical decision-making. | Warshauer-Baker E et al. | — | 2008 | → |
| Genes, race and research ethics: who's minding the store? | Hunt LM et al. | — | 2008 | → |
| Genetics and the social science explanation of individual outcomes. | Freese J | — | 2008 | → |
| Implications of ethnicity for the treatment of hypertensive kidney disease, with an emphasis on African Americans. | Norris KC et al. | — | 2008 | → |
| Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience. | Christensen KD et al. | — | 2008 | → |
| Race, ethnicity, and racism in medical anthropology, 1977-2002. | Gravlee CC et al. | — | 2008 | → |
| The ambiguous meanings of the racial/ethnic categories routinely used in human genetics research. | Hunt LM et al. | — | 2008 | → |
| Too many referrals of low-risk women for BRCA1/2 genetic services by family physicians. | White DB et al. | — | 2008 | → |
| BiDil for heart failure in black patients: implications of the U.S. Food and Drug Administration approval. | Bibbins-Domingo K et al. | — | 2007 | → |
| Can ethical reasoning contribute to better epidemiology? A case study in research on racial health disparities. | de Melo-Martín I et al. | — | 2007 | → |
| Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis. | Bogatkevich GS et al. | — | 2007 | → |
| [Importance of genetics for health inequalities]. | Mielck A et al. | — | 2007 | → |
| Mixed Race: Understanding Difference in the Genome Era. | Phillips EM et al. | — | 2007 | → |
| Psychosocial contributors to preterm birth must be considered. | Moultrie SZ | — | 2007 | → |
| [Race and epidemiology: strategies to build on biological differences]. | Laguardia J | — | 2007 | → |
| Racial categories in medical practice: how useful are they? | Braun L et al. | — | 2007 | → |
| The future of genomic nursing research. | Conley YP et al. | — | 2007 | → |
| Will genomics widen or help heal the schism between medicine and public health? | Khoury MJ et al. | — | 2007 | → |
| An overview of ethnicity and assessment of family history in primary care settings. | Maradiegue A et al. | — | 2006 | → |
| A public health genetic approach for schizophrenia. | Danese A | — | 2006 | → |
| Ashkenazi Jews and breast cancer: the consequences of linking ethnic identity to genetic disease. | Brandt-Rauf SI et al. | — | 2006 | → |
| Attitudes and beliefs of pediatricians and genetic counselors regarding testing and screening for CF and G6PD: implications for policy. | Koopmans J et al. | — | 2006 | → |
| BiDil: assessing a race-based pharmaceutical. | Brody H et al. | — | 2006 | → |
| Dissecting racial and ethnic differences. | Risch N | — | 2006 | → |
| Genes, race, and population: avoiding a collision of categories. | Kahn J | — | 2006 | → |
| Genetics, epidemiology, and cancer disparities: is it black and white? | Rebbeck TR et al. | — | 2006 | → |
| Health disparities and differences in asthma: concepts and controversies. | Shanawani H | — | 2006 | → |
| National data for monitoring and evaluating racial and ethnic health inequities: where do we go from here? | Griffith DM et al. | — | 2006 | → |
| Sample bias among women with retained DNA samples for future genetic studies. | Aagaard-Tillery K et al. | — | 2006 | → |
| The burden of disease associated with being African-American in the United States and the contribution of socio-economic status. | Franks P et al. | — | 2006 | → |
| The routinisation of genomics and genetics: implications for ethical practices. | Foster MW et al. | — | 2006 | → |
| What role for public health in genetics and vice versa? | Holtzman NA | — | 2006 | → |
| Blazing a trail: a public health research agenda in genomics and chronic disease. | McBride CM | — | 2005 | → |
| Changes in reporting of race/ethnicity, socioeconomic status, gender, and age over 10 years. | Brahan D et al. | — | 2005 | → |
| Contributions of public health to genetics education for health care professionals. | Burke W | — | 2005 | → |
| Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension. | Dries DL et al. | — | 2005 | → |
| Does race have a place in biotechnological research? | McCain J | — | 2005 | → |
| Eliminating disparities in cardiovascular health: six strategic imperatives and a framework for action. | Mensah GA | — | 2005 | → |
| Ethnicity, ancestry, and race in molecular epidemiologic research. | Rebbeck TR et al. | — | 2005 | → |
| Genes, environment, and race: quantitative genetic approaches. | Whitfield KE et al. | — | 2005 | → |
| Genes, race, and psychology in the genome era: an introduction. | Anderson NB et al. | — | 2005 | → |
| Genetic diversity and new therapeutic concepts. | Shastry BS | — | 2005 | → |
| In the eye of the storm: race and genomics in research and practice. | Wang VO et al. | — | 2005 | → |
| Measurement issues in health disparities research. | Ramírez M et al. | — | 2005 | → |
| personalized medicine and pharmacogenomics: ethical and social challenges. | Lee SS | — | 2005 | → |
| Race, genes and preterm delivery. | Fiscella K | — | 2005 | → |
| Stormy weather: race, gene expression, and the science of health disparities. | Krieger N | — | 2005 | → |
| The use of race variables in genetic studies of complex traits and the goal of reducing health disparities: a transdisciplinary perspective. | Shields AE et al. | — | 2005 | → |
| The use of racial, ethnic, and ancestral categories in human genetics research. | Race et al. | — | 2005 | → |
| When timing is of the essence. | McCain J | — | 2005 | → |
| Assessing genetic contributions to phenotypic differences among 'racial' and 'ethnic' groups. | Mountain JL et al. | — | 2004 | → |
| What we do and don't know about 'race', 'ethnicity', genetics and health at the dawn of the genome era. | Collins FS | — | 2004 | → |