Interaction between SLC6A4 promoter variants and childhood trauma on the age at onset of bipolar disorders.
paper
Cited
Public
- Authors
- Etain, B; Lajnef, M; Henrion, A; Dargél, A A; Stertz, L; Kapczinski, F; Mathieu, F; Henry, C; Gard, S; Kahn, J P; Leboyer, M; Jamain, S; Bellivier, F
- Year
- 2015
- Journal
- Scientific reports
- PMID
- 26542422
- DOI
- 10.1038/srep16301
- PMCID
- PMC4635347
Age at onset (AAO) of bipolar disorders (BD) could be influenced both by a repeat length polymorphism (5HTTLPR) in the promoter region of the serotonin transporter gene (SLC6A4) and exposure to childhood trauma. We assessed 308 euthymic patients with BD for the AAO of their first mood episode and childhood trauma. Patients were genotyped for the 5HTTLPR (long/short variant) and the rs25531. Genotypes were classified on functional significance (LL, LS, SS). A sample of 126 Brazilian euthymic patients with BD was used for replication. In the French sample, the correlation between AAO and trauma score was observed only among 'SS' homozygotes (p = 0.002) but not among 'L' allele carriers. A history of at least one trauma decreased the AAO only in 'SS' homozygotes (p = 0.001). These results remained significant after correction using FDR. Regression models suggested an interaction between emotional neglect and 'SS' genotype on the AAO (p = 0.009) and no further interaction with other trauma subtypes. Partial replication was obtained in the Brazilian sample, showing an interaction between emotional abuse and 'LS' genotype on the AAO (p = 0.02). In conclusion, an effect of childhood trauma on AAO of BD was observed only in patients who carry a specific stress responsiveness-related SLC6A4 promoter genotype.
Medians and Median Absolute Deviations of AAO according the absence/presence of trauma and the SLC6A4 genotypes.Legend: SLC6A4 (serotonin transporter gene).
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| Citation | PMID | DOI | Status |
|---|---|---|---|
| AasM. et al. Additive effects of childhood abuse and cannabis abuse on clinical expressions of bipolar disorders. Psychol Med, 1–10, 10.1017/S0033291713002316 (2013).24028906 | — | — | — |
| American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, French Edition: by Masson, Paris. (1994). | — | — | — |
| BalestriM., CalatiR., SerrettiA. & De RonchiD. Genetic modulation of personality traits: a systematic review of the literature. International clinical psychopharmacology 29, 1–15, 10.1097/YIC.0b013e328364590b (2014).24100617 | — | — | — |
| BauerM. et al. Impact of sunlight on the age of onset of bipolar disorder. Bipolar Disord 14, 654–663, 10.1111/j.1399-5618.2012.01025.x (2012).22612720PMC3525652 | — | — | — |
| BauerM. et al. Influence of light exposure during early life on the age of onset of bipolar disorder. J Psychiatr Res 64, 1–8, 10.1016/j.jpsychires.2015.03.013 (2015).25862378 | — | — | — |
| BauerM. et al. Relationship between sunlight and the age of onset of bipolar disorder: an international multisite study. J Affect Disord 167, 104–111, 10.1016/j.jad.2014.05.032 (2014).24953482 | — | — | — |
| BechP., RafaelsenO. J., KrampP. & BolwigT. G. The mania rating scale: scale construction and inter-observer agreement. Neuropharmacology 17, 430–431 (1978).67316110.1016/0028-3908(78)90022-9 | — | — | — |
| BellivierF. et al. Age at onset in bipolar I affective disorder in the USA and Europe. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 15, 369–376, 10.3109/15622975.2011.639801 (2014).22188366 | — | — | — |
| BellivierF. et al. Age at onset in bipolar I affective disorder: further evidence for three subgroups. Am J Psychiatry 160, 999–1001 (2003).1272770810.1176/appi.ajp.160.5.999 | — | — | — |
| BellivierF. et al. Apolipoprotein E gene polymorphism in early and late onset bipolar patients. Neurosci Lett. 233, 45–48. (1997).932423610.1016/s0304-3940(97)00624-1 | — | — | — |
| BellivierF. et al. Serotonin transporter gene polymorphism influences age at onset in patients with bipolar affective disorder. Neurosci Lett 334, 17–20 (2002).1243176510.1016/s0304-3940(02)01029-7 | — | — | — |
| BellivierF., GolmardJ. L., HenryC., LeboyerM. & SchurhoffF. Admixture analysis of age at onset in bipolar I affective disorder. Arch Gen Psychiatry 58, 510–512 (2001).1134353310.1001/archpsyc.58.5.510 | — | — | — |
| BenedettiF. et al. A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression. Neurosci Lett 368, 123–126 (2004).1535143210.1016/j.neulet.2004.06.050 | — | — | — |
| BenedettiF. et al. A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder. Neurosci Lett 445, 184–187, 10.1016/j.neulet.2008.09.002 (2008).18789374 | — | — | — |
| BenedettiF. et al. The serotonin transporter genotype modulates the relationship between early stress and adult suicidality in bipolar disorder. Bipolar Disord 16, 857–866, 10.1111/bdi.12250 (2014).25219494 | — | — | — |
| BernsteinD. P. & FinkL. Childhood Trauma Questionnaire: a retrospective self-report - Manual. (The psychological Corporation—Harcourt Brace and Company. 1998). | — | — | — |
| BernsteinD. P. et al. Initial reliability and validity of a new retrospective measure of child abuse and neglect. Am J Psychiatry 151, 1132–1136 (1994).803724610.1176/ajp.151.8.1132 | — | — | — |
| BraehlerC. et al. Diurnal cortisol in schizophrenia patients with childhood trauma. Schizophr Res 79, 353–354 (2005).1605530710.1016/j.schres.2004.07.007 | — | — | — |
| BremnerJ. D. Neuroimaging of childhood trauma. Semin Clin Neuropsychiatry 7, 104–112 (2002).1195393410.1053/scnp.2002.31787 | — | — | — |
| CaspiA. et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386–389 (2003).1286976610.1126/science.1083968 | — | — | — |
| CaspiA., HaririA. R., HolmesA., UherR. & MoffittT. E. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 167, 509–527, 10.1176/appi.ajp.2010.09101452 (2010).20231323PMC2943341 | — | — | — |
| ChiaroniP. et al. Possible involvement of the dopamine D3 receptor locus in subtypes of bipolar affective disorder. Psychiatr Genet 10, 43–49 (2000).1090912810.1097/00041444-200010010-00008 | — | — | — |
| Daruy-FilhoL., BrietzkeE., LaferB. & Grassi-OliveiraR. Childhood maltreatment and clinical outcomes of bipolar disorder. Acta Psychiatr Scand 124, 427–434, 10.1111/j.1600-0447.2011.01756.x (2011).21848703 | — | — | — |
| De PradierM., GorwoodP., BeaufilsB., AdesJ. & DubertretC. Influence of the serotonin transporter gene polymorphism, cannabis and childhood sexual abuse on phenotype of bipolar disorder: a preliminary study. European psychiatry: the journal of the Association of European Psychiatrists 25, 323–327, 10.1016/j.eurpsy.2009.10.002 (2010).20434316 | — | — | — |
| DelBelloM. P. et al. Prior stimulant treatment in adolescents with bipolar disorder: association with age at onset. Bipolar Disord 3, 53–57 (2001).1133306210.1034/j.1399-5618.2001.030201.x | — | — | — |
| DiLilloD. et al. Retrospective assessment of childhood sexual and physical abuse: a comparison of scaled and behaviorally specific approaches. Assessment. 13, 297–312 (2006).1688028110.1177/1073191106288391 | — | — | — |
| DizierM. H. et al. Genetic heterogeneity according to age at onset in bipolar disorder: a combined positional cloning and candidate gene approach. American journal of medical genetics. Part B, Neuropsychiatric genetics: the official publication of the International Society of Psychiatric Genetics 159B, 653–659, 10.1002/ajmg.b.32069 (2012).22628130 | — | — | — |
| Dmitrzak-WeglarzM. et al. Dopamine receptor D1 gene -48A/G polymorphism is associated with bipolar illness but not with schizophrenia in a Polish population. Neuropsychobiology 53, 46–50 (2006).1639740410.1159/000090703 | — | — | — |
| DrabantE. M. et al. Neural mechanisms underlying 5-HTTLPR-related sensitivity to acute stress. Am J Psychiatry 169, 397–405, 10.1176/appi.ajp.2011.10111699 (2012).22362395PMC3761065 | — | — | — |
| DuncanL. E. & KellerM. C. A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. Am J Psychiatry 168, 1041–1049, 10.1176/appi.ajp.2011.11020191 (2011).21890791PMC3222234 | — | — | — |
| EtainB. et al. A SNAP25 promoter variant is associated with early-onset bipolar disorder and a high expression level in brain. Mol Psychiatry 15, 748–755, 10.1038/mp.2008.148 (2010).19125158PMC2937032 | — | — | — |
| EtainB. et al. Childhood Trauma Is Associated With Severe Clinical Characteristics of Bipolar Disorders. Journal of Clinical Psychiatry 74, 991–998 (2013).2422975010.4088/JCP.13m08353 | — | — | — |
| EtainB. et al. Clinical expression of bipolar disorder type I as a function of age and polarity at onset: convergent findings in samples from France and the United States. J Clin Psychiatry 73, e561–566, 10.4088/JCP.10m06504 (2012).22579163 | — | — | — |
| Evans-LackoS. E., ZeberJ. E., GonzalezJ. M. & OlveraR. L. Medical comorbidity among youth diagnosed with bipolar disorder in the United States. J Clin Psychiatry 70, 1461–1466, 10.4088/JCP.08m04871 (2009).19744408 | — | — | — |
| FicksC. A. & WaldmanI. D. Candidate Genes for Aggression and Antisocial Behavior: A Meta-analysis of Association Studies of the 5HTTLPR and MAOA-uVNTR. Behavior genetics, 10.1007/s10519-014-9661-y (2014).24902785 | — | — | — |
| FirstM., SptzerR., GibbonM. & WilliamJ. Structured Clinical Interview for DSM-IV Axis I Disorders—Patient Edition (SCID-I/P). (New York State Psychiatric Institute., 1995). | — | — | — |
| FisherH. & HosangG. Childhood Maltreatment and Bipolar Disorder: A Critical Review of the Evidence. Mind & Brain, the Journal of Psychiatry, 1–11 (2010). | — | — | — |
| GeoffroyP. A. et al. Reconsideration of bipolar disorder as a developmental disorder: Importance of the time of onset. Journal of physiology, Paris 107, 278–285, 10.1016/j.jphysparis.2013.03.006 (2013).23542544 | — | — | — |
| GizerI. R., FicksC. & WaldmanI. D. Candidate gene studies of ADHD: a meta-analytic review. Human genetics 126, 51–90, 10.1007/s00439-009-0694-x (2009).19506906 | — | — | — |
| GoodmanM., NewA. & SieverL. Trauma, genes, and the neurobiology of personality disorders. Ann N Y Acad Sci 1032, 104–116 (2004).1567739810.1196/annals.1314.008 | — | — | — |
| Grassi-OliveiraR., SteinL. M. & PezziJ. C. [Translation and content validation of the Childhood Trauma Questionnaire into Portuguese language]. Revista de saude publica 40, 249–255, /S0034-89102006000200010 (2006).1658303510.1590/s0034-89102006000200010 | — | — | — |
| HardtJ. & RutterM. Validity of adult retrospective reports of adverse childhood experiences: review of the evidence. J Child Psychol Psychiatry. 45, 260–273. (2004).1498224010.1111/j.1469-7610.2004.00218.x | — | — | — |
| HaririA. R. & HolmesA. Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn Sci. 10, 182–191. Epub 2006 Mar 2010. (2006).1653046310.1016/j.tics.2006.02.011 | — | — | — |
| HeffnerJ. L., DelBelloM. P., FleckD. E., AnthenelliR. M. & StrakowskiS. M. Cigarette smoking in the early course of bipolar disorder: association with ages-at-onset of alcohol and marijuana use. Bipolar Disord 10, 838–845, 10.1111/j.1399-5618.2008.00630.x (2008).19032716 | — | — | — |
| HeimC. & NemeroffC. B. The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry 49, 1023–1039 (2001).1143084410.1016/s0006-3223(01)01157-x | — | — | — |
| HeimC. et al. The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis. Depress Anxiety 15, 117–125 (2002).1200118010.1002/da.10015 | — | — | — |
| JamainS. et al. Common and rare variant analysis in early-onset bipolar disorder vulnerability. PloS one 9, e104326, 10.1371/journal.pone.0104326 (2014).25111785PMC4128749 | — | — | — |
| KargK., BurmeisterM., SheddenK. & SenS. The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. Arch Gen Psychiatry 68, 444–454, 10.1001/archgenpsychiatry.2010.189 (2011).21199959PMC3740203 | — | — | — |
| LagerbergT. V. et al. Excessive cannabis use is associated with earlier age at onset in bipolar disorder. European archives of psychiatry and clinical neuroscience 261, 397–405, 10.1007/s00406-011-0188-4 (2011).21267743PMC3159738 | — | — | — |
| LagerbergT. V. et al. Indications of a dose-response relationship between cannabis use and age at onset in bipolar disorder. Psychiatry Res 215, 101–104, 10.1016/j.psychres.2013.10.029 (2014).24262665 | — | — | — |
| LeboyerM., HenryC., Paillere-MartinotM. L. & BellivierF. Age at onset in bipolar affective disorders: a review. Bipolar Disord 7, 111–118 (2005).1576285110.1111/j.1399-5618.2005.00181.x | — | — | — |
| LeeY. J. & KimY. K. The impact of glycogen synthase kinase 3beta gene on psychotic mania in bipolar disorder patients. Progress in neuro-psychopharmacology & biological psychiatry 35, 1303–1308, 10.1016/j.pnpbp.2011.04.006 (2011).21549170 | — | — | — |
| Lev-RanS., Le FollB., McKenzieK., GeorgeT. P. & RehmJ. Bipolar disorder and co-occurring cannabis use disorders: Characteristics, co-morbidities and clinical correlates. Psychiatry Res, 10.1016/j.psychres.2012.12.014 (2013).23312479 | — | — | — |
| LinP. I. et al. Clinical correlates and familial aggregation of age at onset in bipolar disorder. Am J Psychiatry 163, 240–246 (2006).1644947710.1176/appi.ajp.163.2.240 | — | — | — |
| LinY. F., HuangM. C. & LiuH. C. Glycogen synthase kinase 3beta gene polymorphisms may be associated with bipolar I disorder and the therapeutic response to lithium. J Affect Disord 147, 401–406, 10.1016/j.jad.2012.08.025 (2013).23021822 | — | — | — |
| ManchiaM. et al. Mixture regression analysis on age at onset in bipolar disorder patients: investigation of the role of serotonergic genes. European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology 20, 663–670, 10.1016/j.euroneuro.2010.04.001 (2010).20452754 | — | — | — |
| ManiglioR. The impact of child sexual abuse on the course of bipolar disorder: a systematic review. Bipolar Disord 15, 341–358, 10.1111/bdi.12050 (2013).23346867 | — | — | — |
| MassatI. et al. COMT and age at onset in mood disorders: a replication and extension study. Neurosci Lett 498, 218–221, 10.1016/j.neulet.2011.05.012 (2011).21600957 | — | — | — |
| MillerS. et al. Brain-derived neurotrophic factor val66met genotype and early life stress effects upon bipolar course. J Psychiatr Res 47, 252–258, 10.1016/j.jpsychires.2012.10.015 (2013).23182421PMC3529984 | — | — | — |
| MinH. J. et al. Association of the Brain-derived Neurotrophic Factor Gene and Clinical Features of Bipolar Disorder in Korea. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 10, 163–167, 10.9758/cpn.2012.10.3.163 (2012).23430274PMC3569161 | — | — | — |
| MontgomeryS. A. & AsbergM. A new depression scale designed to be sensitive to change. Br J Psychiatry 134, 382–389 (1979).44478810.1192/bjp.134.4.382 | — | — | — |
| MunafoM. R., BrownS. M. & HaririA. R. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry 63, 852–857, 10.1016/j.biopsych.2007.08.016 (2008).17949693PMC2755289 | — | — | — |
| MunafoM. R., DurrantC., LewisG. & FlintJ. Gene X environment interactions at the serotonin transporter locus. Biol Psychiatry 65, 211–219, 10.1016/j.biopsych.2008.06.009 (2009).18691701 | — | — | — |
| NurnbergerJ. I.Jr. et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry 51, 849–859; discussion 863–844 (1994).794487410.1001/archpsyc.1994.03950110009002 | — | — | — |
| OliveiraJ. et al. Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disorders. PloS one 10, e0119702, 10.1371/journal.pone.0119702 (2015).25790282PMC4366110 | — | — | — |
| Ospina-DuqueJ. et al. An association study of bipolar mood disorder (type I) with the 5-HTTLPR serotonin transporter polymorphism in a human population isolate from Colombia. Neurosci Lett 292, 199–202 (2000).1101831110.1016/s0304-3940(00)01464-6 | — | — | — |
| O’MahonyE. et al. Sibling pairs with affective disorders: resemblance of demographic and clinical features. Psychol Med 32, 55–61 (2002).1188373010.1017/s0033291701004986 | — | — | — |
| PaquetteD., LaporteL., BigrasM. & ZoccolilloM. Validation de la version française du CTQ et prévalence de l’histoire de maltraitance Santé Mentale au Québec 29, 201–220 (2004).1547057310.7202/008831ar | — | — | — |
| Pergamin-HightL., Bakermans-KranenburgM. J., van IjzendoornM. H. & Bar-HaimY. Variations in the promoter region of the serotonin transporter gene and biased attention for emotional information: a meta-analysis. Biol Psychiatry 71, 373–379, 10.1016/j.biopsych.2011.10.030 (2012).22138391 | — | — | — |
| PriebeL. et al. Genome-wide survey implicates the influence of copy number variants (CNVs) in the development of early-onset bipolar disorder. Mol Psychiatry 17, 421–432, 10.1038/mp.2011.8 (2012).21358712 | — | — | — |
| ReichartC. G. & NolenW. A. Earlier onset of bipolar disorder in children by antidepressants or stimulants? An hypothesis. J Affect Disord 78, 81–84 (2004).1467280110.1016/s0165-0327(02)00180-5 | — | — | — |
| RischN. et al. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA 301, 2462–2471, 10.1001/jama.2009.878 (2009).19531786PMC2938776 | — | — | — |
| RoyA. Self-rated childhood emotional neglect and CSF monoamine indices in abstinent cocaine-abusing adults: possible implications for suicidal behavior. Psychiatry Res 112, 69–75 (2002).1237945210.1016/s0165-1781(02)00176-2 | — | — | — |
| RoyA. Urinary free cortisol and childhood trauma in cocaine dependent adults. J Psychiatr Res 36, 173–177 (2002).1188669510.1016/s0022-3956(02)00002-x | — | — | — |
| RoyC. A. & PerryJ. C. Instruments for the assessment of childhood trauma in adults. J Nerv Ment Dis. 192, 343–351. (2004).1512688810.1097/01.nmd.0000126701.23121.fa | — | — | — |
| SchulzeT. G., HedekerD., ZandiP., RietschelM. & McMahonF. J. What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristics. Arch Gen Psychiatry 63, 1368–1376 (2006).1714601110.1001/archpsyc.63.12.1368 | — | — | — |
| SpijkerA. T. et al. Glucocorticoid and mineralocorticoid receptor polymorphisms and clinical characteristics in bipolar disorder patients. Psychoneuroendocrinology 36, 1460–1469, 10.1016/j.psyneuen.2011.03.020 (2011).21531081 | — | — | — |
| SquassinaA. et al. Age at onset in bipolar disorder: Investigation of the role of TaqIA polymorphism of DRD2 gene in a Sardinian sample. European psychiatry: the journal of the Association of European Psychiatrists 26, 141–143, 10.1016/j.eurpsy.2010.09.013 (2011).21292452 | — | — | — |
| StataCorp. Stata Statistical Software: Release 12. College Station, TX: StataCorp LP (2011). | — | — | — |
| StroberM. et al. A family study of bipolar I disorder in adolescence. Early onset of symptoms linked to increased familial loading and lithium resistance. J Affect Disord. 15, 255–268. (1988).297529810.1016/0165-0327(88)90023-7 | — | — | — |
| UherR. Gene-environment interactions in severe mental illness. Frontiers in psychiatry 5, 48, 10.3389/fpsyt.2014.00048 (2014).24860514PMC4030208 | — | — | — |
| WendlandJ. R., MartinB. J., KruseM. R., LeschK. P. & MurphyD. L. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 11, 224–226, 10.1038/sj.mp.4001789 (2006).16402131 | — | — | — |
| ZhangD. et al. Singleton deletions throughout the genome increase risk of bipolar disorder. Mol Psychiatry 14, 376–380, 10.1038/mp.2008.144 (2009).19114987PMC2735188 | — | — | — |
| ZhangX. et al. Association of genetic variation in CACNA1C with bipolar disorder in Han Chinese. J Affect Disord, 10.1016/j.jad.2013.04.004 (2013).23680436 | — | — | — |
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | 2018 | 28373689 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Genetic Predisposition and Genetic Resilience Factors in Stress-Related Disorders During the Developmental Age: A Narrative Review. | Raffagnato A et al. | — | 2025 | → |
| The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders. | Lippard ETC et al. | — | 2023 | → |
| Biomarker potential of hsa-miR-145-5p in peripheral whole blood of manic bipolar I patients. | Tekin SS et al. | — | 2022 | → |
| Going beyond risk factor: Childhood maltreatment and associated modifiable targets to improve life-long outcomes in mood disorders. | Lippard ETC et al. | — | 2022 | → |
| Bipolar disorder: Trimodal age-at-onset distribution. | Bolton S et al. | — | 2021 | → |
| Childhood Maltreatment in Bipolar Disorders. | Etain B et al. | — | 2021 | → |
| Childhood maltreatment, prefrontal-paralimbic gray matter volume, and substance use in young adults and interactions with risk for bipolar disorder. | Kirsch DE et al. | — | 2021 | → |
| Interaction between adverse childhood experiences and polygenic risk in patients with bipolar disorder. | Park YM et al. | — | 2020 | → |
| Proof-of-concept study of a multi-gene risk score in adolescent bipolar disorder. | Dimick MK et al. | — | 2020 | → |
| The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders. | Lippard ETC et al. | — | 2020 | → |
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | Culverhouse RC et al. | — | 2018 | → |
| Childhood trauma is associated with increased brain responses to emotionally negative as compared with positive faces in patients with psychotic disorders. | Aas M et al. | — | 2017 | → |
| Environmental factors, life events, and trauma in the course of bipolar disorder. | Aldinger F et al. | — | 2017 | → |
| The role of childhood trauma in bipolar disorders. | Aas M et al. | — | 2016 | → |