Drug wanting: behavioral sensitization and relapse to drug-seeking behavior.
- Authors
- Steketee, Jeffery D; Kalivas, Peter W
- Year
- 2011
- Journal
- Pharmacological reviews
- PMID
- 21490129
- DOI
- 10.1124/pr.109.001933
- PMCID
- PMC3082449
Repeated exposure to drugs of abuse enhances the motor-stimulant response to these drugs, a phenomenon termed behavioral sensitization. Animals that are extinguished from self-administration training readily relapse to drug, conditioned cue, or stress priming. The involvement of sensitization in reinstated drug-seeking behavior remains controversial. This review describes sensitization and reinstated drug seeking as behavioral events, and the neural circuitry, neurochemistry, and neuropharmacology underlying both behavioral models will be described, compared, and contrasted. It seems that although sensitization and reinstatement involve overlapping circuitry and neurotransmitter and receptor systems, the role of sensitization in reinstatement remains ill-defined. Nevertheless, it is argued that sensitization remains a useful model for determining the neural basis of addiction, and an example is provided in which data from sensitization studies led to potential pharmacotherapies that have been tested in animal models of relapse and in human addicts.
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|---|---|---|---|---|
| Administration of an extrasynaptic Ξ΄-subunit GABA<sub>A</sub> receptor agonist in the prelimbic cortex attenuates methamphetamine sensitisation and relapse to methamphetamine-seeking behaviour in male rats. | van den Buuse M et al. | β | 2026 | β |
| Delta Opioid Receptors within the Cortico-Thalamic Circuitry Underlie Hyperactivity Induced by High-Dose Morphine. | Li CY et al. | β | 2026 | β |
| Distinct interneuronal dynamics selectively gate target-specific cortical projections in drug seeking. | Jeong M et al. | β | 2026 | β |
| Dopamine D2 Receptors, D1/D2 Receptor Heteromers and CaMKII Signaling in the Neurobiology of Drug Addiction. | Jia W et al. | β | 2026 | β |
| Effect of Natural Rewards on Substance Use Disorder: An Incentive Sensitization Perspective. | Zheng W et al. | β | 2026 | β |
| Estrous Cycle Influences Cell-Type-Specific Translatomic Signatures of Repeated Ketamine Exposure in the Rat Nucleus Accumbens. | Saland SK et al. | β | 2026 | β |
| Fentanyl, Methamphetamine and Polysubstance Use Differentially Affect Locomotor Sensitisation and Social Behaviour in Rats: Psychedelic Treatment Reverses Social Deficits. | Salinsky LM et al. | β | 2026 | β |
| Nicotine produces a sex- and subregion-specific hypoglutamatergic state in rodent amygdala which can be reversed by motor-skill training. | Lucente E et al. | β | 2026 | β |
| Tirzepatide attenuates mesolimbic cocaine-evoked dopamine levels and reduces cocaine taking, motivation and seeking behaviours in male rodents. | Edvardsson CE et al. | β | 2026 | β |
| Treatment with rapamycin prevents induction and expression of locomotor sensitization to synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV) in mice. | Wojcieszak J et al. | β | 2026 | β |
| A proposed mechanism for amphetamine-induced behavioral sensitization involving the vesicular monoamine transporter. | Garcia V et al. | β | 2025 | β |
| Astrocytic regulation of cocaine locomotor sensitization in EcoHIV infected mice. | Xie Q et al. | β | 2025 | β |
| COT-TT vaccine attenuates induction and expression of cocaine-induced behavioral sensitization in rats: a dose-response study. | Barbosa-Mendez S et al. | β | 2025 | β |
| Generalized cue reactivity in rat dopamine neurons after opioids. | Lehmann CM et al. | β | 2025 | β |
| Generalized Tetanus Associated With Malaria and Probable Meningitis in a 4-Year-Old Patient: A Case Report in Limbe Regional Hospital, Cameroon. | Tchuisseu Ngapjang CD et al. | β | 2025 | β |
| Morphine self-administration decreases intrinsic excitability of accumbal medium spiny neurons and suppresses the innate immune system in male Wistar rats. | Adermark L et al. | β | 2025 | β |
| Nandrolone alters the behavioral response to cocaine as well as striatal and cortical dopamine receptors of prepubertal male rats. | Freire-Arvelo JA et al. | β | 2025 | β |
| Polygalae Radix Attenuates Methamphetamine-Induced Behavioral Sensitization Through the TrkB/ERK Pathway in the Caudate Putamen of Mice. | Qian H et al. | β | 2025 | β |
| Rewarding properties of L-Dopa in experimental parkinsonism are mediated by sensitized dopamine D1 receptors in the dorsal striatum. | Plewnia C et al. | β | 2025 | β |
| Sex differences in stress-modulated cocaine vulnerability: female rodents are more sensitive to the effects of stress exposure at different developmental stages. | MartΓnez-Caballero MΓ et al. | β | 2025 | β |
| The Effect and Mechanism of Magnesium Valproate on Methamphetamine-Addicted Rats. | Li Y et al. | β | 2025 | β |
| The Effect of N-Acetylcysteine on Behavioral Sensitization to Methamphetamine in Mice. | MΓ‘chalovΓ‘ A et al. | β | 2025 | β |
| Toluene Toxicity in the Brain: From Cellular Targets to Molecular Mechanisms. | Shaw AA et al. | β | 2025 | β |
| Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens. | Fu XP et al. | β | 2025 | β |
| Ξ±-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice. | Xu W et al. | β | 2025 | β |
| Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral sensitization. | Ahmed MR et al. | β | 2024 | β |
| Conditioned place preference with low dose mixtures of Ξ±-pyrrolidinopentiophenone (Ξ±-PVP) and 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley rats. | Shaykin JD et al. | β | 2024 | β |
| Disrupting heroin-associated memory reconsolidation through actin polymerization inhibition in the nucleus accumbens core. | Zhao H et al. | β | 2024 | β |
| Effect of exercise duration on toluene-induced locomotor sensitization in mice: a focus on the Renin Angiotensin System. | Gallardo-OrtΓz IA et al. | β | 2024 | β |
| Effects of Hydrocodone Overdose and Ceftriaxone on Astrocytic Glutamate Transporters and Glutamate Receptors, and Associated Signaling in Nucleus Accumbens as well as Locomotor Activity in C57/BL Mice. | Wong W et al. | β | 2024 | β |
| Enhancing translation: A need to leverage complex preclinical models of addictive drugs to accelerate substance use treatment options. | Corley C et al. | β | 2024 | β |
| Established sensitization of ethanol-induced locomotor activity is not reversed by psilocybin or the 5-HT<sub>2A</sub> receptor agonist TCB-2 in male DBA/2J mice. | Fletcher PJ et al. | β | 2024 | β |
| Identification of the circRNA-miRNA-mRNA network for treating methamphetamine-induced relapse and behavioral sensitization with cannabidiol. | Liu L et al. | β | 2024 | β |
| Isradipine, an L-type calcium channel blocker, attenuates cocaine effects in mice by reducing central glutamate release. | Lima ALD et al. | β | 2024 | β |
| <i>Tmod2</i> Is a Regulator of Cocaine Responses through Control of Striatal and Cortical Excitability and Drug-Induced Plasticity. | Mitra A et al. | β | 2024 | β |
| Nandrolone alters the behavioral response to cocaine as well as striatal and cortical dopamine receptors of prepubertal male rats | Freire-Arvelo JA et al. | β | 2024 | β |
| Nicotinic Ξ±7 receptors on cholinergic neurons in the striatum mediate cocaine-reinforcement, but not food reward. | Fritz M et al. | β | 2024 | β |
| N-Isopropylbenzylamine-induced conditioned place preference, sensitization behaviour and self-administration in rodents. | Lai M et al. | β | 2024 | β |
| Parental Exposure to Morphine Before Conception Decreases Morphine and Cocaine-Induced Locomotor Sensitization in Male Offspring. | Heidari A et al. | β | 2024 | β |
| Restoring GABA<sub><i>B</i></sub> receptor expression in the ventral tegmental area of methamphetamine addicted mice inhibits locomotor sensitization and drug seeking behavior. | Hleihil M et al. | β | 2024 | β |
| Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses. | Gobira PH et al. | β | 2024 | β |
| Single-nucleus RNA-sequencing of orbitofrontal cortex in rat model of methamphetamine-induced sensitization. | Li Q et al. | β | 2024 | β |
| Advancing the preclinical study of comorbid neuroHIV and substance use disorders: Current perspectives and future directions. | Namba MD et al. | β | 2023 | β |
| An ethogram analysis of cutaneous thermal pain sensitivity and oxycodone reward-related behaviors in rats. | Brice-Tutt AC et al. | β | 2023 | β |
| Behavioral sensitization to psychostimulants and opioids: What is known in rodents and what still needs to be explored in humans? | Delage C et al. | β | 2023 | β |
| Cellular signaling pathways as plastic, proto-cognitive systems: Implications for biomedicine. | Mathews J et al. | β | 2023 | β |
| Cocaine induces locomotor sensitization through a dopamine-dependent VTA-mPFC-FrA cortico-cortical pathway in male mice. | Wang L et al. | β | 2023 | β |
| Disrupting astrocyte-neuron lactate transport prevents cocaine seeking after prolonged withdrawal. | Chen W et al. | β | 2023 | β |
| Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters in <i>Drosophila melanogaster</i> Brain following Volatilized Cocaine or Methamphetamine Administrations. | FiloΕ‘eviΔ VujnoviΔ A et al. | β | 2023 | β |
| Distinctive Neuroanatomic Regions Involved in Cocaine-Induced Behavioral Sensitization in Mice. | Santos-Baldaia RD et al. | β | 2023 | β |
| Effects of ambient temperature on locomotor activity and place conditioning elicited by abused psychostimulants in mice: Role of 3,4-methylenedioxy moiety. | Gannon BM et al. | β | 2023 | β |
| <i>Ξ²</i>-Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives. | Wess J et al. | β | 2023 | β |
| Metformin Prevents Cocaine Sensitization: Involvement of Adenosine Monophosphate-Activated Protein Kinase Trafficking between Subcellular Compartments in the Corticostriatal Reward Circuit. | Aruldas R et al. | β | 2023 | β |
| Normalization of the H3K9me2/H3K14ac-ΞFosB pathway in the nucleus accumbens underlying the reversal of morphine-induced behavioural and synaptic plasticity by Compound 511. | Wang Q et al. | β | 2023 | β |
| Repeated chemogenetic activation of dopaminergic neurons induces reversible changes in baseline and amphetamine-induced behaviors. | Chohan MO et al. | β | 2023 | β |
| Repeated dosing with cocaine produces strain-dependent effects on responding for conditioned reinforcement in Collaborative Cross mice. | Bailey LS et al. | β | 2023 | β |
| Reward prediction-errors weighted by cue salience produces addictive behaviours in simulations, with asymmetrical learning and steeper delay discounting. | Kalhan S et al. | β | 2023 | β |
| Rewiring of Prelimbic Inputs to the Nucleus Accumbens Core Underlies Cocaine-Induced Behavioral Sensitization. | Kwon J et al. | β | 2023 | β |
| Sensitization of Hypertension: The Impact of Earlier Life Challenges: Excellence Award for Hypertension Research 2021. | Xue B et al. | β | 2023 | β |
| Sex- and Gender-Specific Drug Abuse Dynamics: The Need for Tailored Therapeutic Approaches. | Marinelli S et al. | β | 2023 | β |
| Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress. | RincΓ³n-CortΓ©s M | β | 2023 | β |
| Sex Differences in Cocaine Sensitization Vary by Mouse Strain. | Chapp AD et al. | β | 2023 | β |
| The Evolving Role of Animal Models in the Discovery and Development of Novel Treatments for Psychiatric Disorders. | Teal LB et al. | β | 2023 | β |
| The role of the L-arginine-NO-cGMP-dependent pathway in the development of sensitization to mephedrone effects on the locomotor activity in mice. | Bielecka-Papierz G et al. | β | 2023 | β |
| Top-down circuitry from the anterior insular cortex to VTA dopamine neurons modulates reward-related memory. | HernΓ‘ndez-Ortiz E et al. | β | 2023 | β |
| Value-based decision-making network functional connectivity correlates with substance use and delay discounting behaviour among young adults. | Loganathan K et al. | β | 2023 | β |
| VU0155041, a positive allosteric modulator of mGluR4, in the nucleus accumbens facilitates extinction and inhibits the reinstatement of morphine-induced conditioned place preference in male rats. | Ebrahimi Z et al. | β | 2023 | β |
| Acute and chronic effects by nicotine on striatal neurotransmission and synaptic plasticity in the female rat brain. | Lucente E et al. | β | 2022 | β |
| Adolescent nicotine potentiates the inhibitory effect of raclopride, a D<sub>2</sub>R antagonist, on phencyclidine-sensitized psychotic-like behavior in mice. | Dutra-Tavares AC et al. | β | 2022 | β |
| Anaesthesia of decapod crustaceans. | de Souza Valente C | β | 2022 | β |
| Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice. | Almeida CAF et al. | β | 2022 | β |
| Captopril and losartan attenuate behavioural sensitization in mice chronically exposed to toluene. | Oros-GonzΓ‘lez A et al. | β | 2022 | β |
| Chronic exposure to cyclohexane induces stereotypic circling, hyperlocomotion, and anxiety-like behavior associated with atypical c-Fos expression in motor- and anxiety-related brain regions. | Campos-OrdoΓ±ez T et al. | β | 2022 | β |
| D2 receptor antagonism enhances cocaine-induced behavioral sensitization in female, but not male Japanese quail ( Coturnix japonica ). | Gill KE et al. | β | 2022 | β |
| Impact of Nutrition, Microbiota Transplant and Weight Loss Surgery on Dopaminergic Alterations in Parkinson's Disease and Obesity. | Hamamah S et al. | β | 2022 | β |
| m-CF<sub>3</sub>-substituted diphenyl diselenide attenuates all phases of morphine-induced behavioral locomotor sensitization in mice. | Rodrigues RF et al. | β | 2022 | β |
| mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1-GluA2 interaction in the nucleus accumbens. | Li HC et al. | β | 2022 | β |
| Mu-opioid receptors in septum mediate the development of behavioural sensitization to a single morphine exposure in male rats. | Li YL et al. | β | 2022 | β |
| Neuroadaptations and TGF-Ξ² signaling: emerging role in models of neuropsychiatric disorders. | Mitra S et al. | β | 2022 | β |
| Neurobiological and neuropharmacological aspects of food addiction. | Guleken Z et al. | β | 2022 | β |
| Neurodevelopmental origins of substance use disorders: Evidence from animal models of early-life adversity and addiction. | Levis SC et al. | β | 2022 | β |
| Opioid and Sucrose Craving Are Accompanied by Unique Behavioral and Affective Profiles after Extended Abstinence in Male and Female Rats. | Mayberry HL et al. | β | 2022 | β |
| Peri-adolescent exposure to (meth)amphetamine in animal models. | Phillips TJ et al. | β | 2022 | β |
| Regulation of cocaine-related behaviours by estrogen and progesterone. | Peart DR et al. | β | 2022 | β |
| Repeated ketamine anesthesia during neurodevelopment upregulates hippocampal activity and enhances drug reward in male mice. | Cui J et al. | β | 2022 | β |
| Role of neuropeptide neuromedin U in the nucleus accumbens shell in cocaine self-administration in male rats. | Kasper JM et al. | β | 2022 | β |
| Sensitization-based risk for substance abuse in vulnerable individuals with ADHD: Review and re-examination of evidence. | Ivanov I et al. | β | 2022 | β |
| Striatal miR-183-5p inhibits methamphetamine-induced locomotion by regulating glucocorticoid receptor signaling. | Song SH et al. | β | 2022 | β |
| Susceptibility to express amphetamine locomotor sensitization correlates with dorsolateral striatum bursting activity and GABAergic synapses in the globus pallidus. | Gatica RI et al. | β | 2022 | β |
| The abuse liability of ketamine: A scoping review of preclinical and clinical studies. | Le TT et al. | β | 2022 | β |
| The collaborative cross strains and their founders vary widely in cocaine-induced behavioral sensitization. | Schoenrock SA et al. | β | 2022 | β |
| The development of behavioral sensitization induced by a single morphine exposure in adult zebrafish (Danio rerio). | Bian Y et al. | β | 2022 | β |
| The Role of Ghrelin/GHS-R1A Signaling in Nonalcohol Drug Addictions. | Sustkova-Fiserova M et al. | β | 2022 | β |
| A breeding strategy to identify modifiers of high genetic risk for methamphetamine intake. | Reed C et al. | β | 2021 | β |
| A Novel Assay Allowing Drug Self-Administration, Extinction, and Reinstatement Testing in Head-Restrained Mice. | Vollmer KM et al. | β | 2021 | β |
| A salience misattribution model for addictive-like behaviors. | Kalhan S et al. | β | 2021 | β |
| Behavioral sensitization induced by methamphetamine causes differential alterations in gene expression and histone acetylation of the prefrontal cortex in rats. | Li H et al. | β | 2021 | β |
| Bidirectional role of acupuncture in the treatment of drug addiction. | Lee MY et al. | β | 2021 | β |
| Chronic stress in adolescence differentially affects cocaine vulnerability in adulthood in a selectively bred rat model of individual differences: role of accumbal dopamine signaling. | Aydin C et al. | β | 2021 | β |
| Cocaine-Seeking Behavior Induced by Orexin A Administration in the Posterior Paraventricular Nucleus of the Thalamus Is Not Long-Lasting: Neuroadaptation of the Orexin System During Cocaine Abstinence. | Matzeu A et al. | β | 2021 | β |
| Combined and sequential effects of alcohol and methamphetamine in animal models. | Stafford AM et al. | β | 2021 | β |
| Distinct Regulation of Dopamine D3 Receptor in the Basolateral Amygdala and Dentate Gyrus during the Reinstatement of Cocaine CPP Induced by Drug Priming and Social Stress. | Guerrero-Bautista R et al. | β | 2021 | β |
| Dopamine D1 receptor-expressing neurons activity is essential for locomotor and sensitizing effects of a single injection of cocaine. | Nakamura Y et al. | β | 2021 | β |
| Effects of fentanyl on acute locomotor activity, behavioral sensitization, and contextual reward in female and male rats. | Gaulden AD et al. | β | 2021 | β |
| Effects of Glucagon-Like Peptide-1 Receptor Agonist Exendin-4 on the Reinstatement of Cocaine-Mediated Conditioned Place Preference in Mice. | Zhu C et al. | β | 2021 | β |
| Effects of the monoamine stabilizer, (-)-OSU6162, on cocaine-induced locomotion and conditioned place preference in mice. | Asth L et al. | β | 2021 | β |
| Extinction blunts paraventricular thalamic contributions to heroin relapse. | Giannotti G et al. | β | 2021 | β |
| Functional validation of a finding from a mouse genome-wide association study shows that Azi2 influences the acute locomotor stimulant response to methamphetamine. | Zhou X et al. | β | 2021 | β |
| Impact of Acute and Persistent Excitation of Prelimbic Pyramidal Neurons on Motor Activity and Trace Fear Learning. | Rose TR et al. | β | 2021 | β |
| Impact of Caffeine on Ethanol-Induced Stimulation and Sensitization: Changes in ERK and DARPP-32 Phosphorylation in Nucleus Accumbens. | Porru S et al. | β | 2021 | β |
| Lack of dopamine D4 receptor participation in mouse hyperdopaminergic locomotor response. | Liao IM et al. | β | 2021 | β |
| Lateral hypothalamic LEPR neurons drive appetitive but not consummatory behaviors. | Siemian JN et al. | β | 2021 | β |
| Locomotor sensitization modulates voluntary self-administration of methamphetamine in Drosophila melanogaster. | Rigo F et al. | β | 2021 | β |
| Long-term high fat diet consumption reversibly alters feeding behavior via a dopamine-associated mechanism in mice. | Altherr E et al. | β | 2021 | β |
| Low-normal doses of methiopropamine induce aggressive behaviour in mice. | Foti F et al. | β | 2021 | β |
| Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward. | Jiang C et al. | β | 2021 | β |
| Phosphorylation of GluN2B subunits of N-methyl-d-aspartate receptors in the frontal association cortex involved in morphine-induced conditioned place preference in mice. | Chen G et al. | β | 2021 | β |
| Pitolisant, a wake-promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetol. | Krief S et al. | β | 2021 | β |
| Prenatal opioid exposure and vulnerability to future substance use disorders in offspring. | Abu Y et al. | β | 2021 | β |
| Sensitization to amphetamine psychostimulant effect: A key role for ventral tegmental area neurotensin type 2 receptors and MAP kinase pathway. | Voyer D et al. | β | 2021 | β |
| The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review. | Li JH et al. | β | 2021 | β |
| The cognitive and behavioral effects of D-amphetamine and nicotine sensitization in adult zebrafish. | Cleal M et al. | β | 2021 | β |
| The duration of withdrawal affects the muscarinic signaling in the nucleus accumbens after chronic morphine exposure in neonatal rats. | Jiang X et al. | β | 2021 | β |
| The Impact of Adolescent Alcohol Exposure on Nicotine Behavioral Sensitization in the Adult Male Neonatal Ventral Hippocampal Lesion Rat. | Sullivan EDK et al. | β | 2021 | β |
| The IntelliCage System: A Review of Its Utility as a Novel Behavioral Platform for a Rodent Model of Substance Use Disorder. | Iman IN et al. | β | 2021 | β |
| The role of CYP2D in rat brain in methamphetamine-induced striatal dopamine and serotonin release and behavioral sensitization. | Stocco MR et al. | β | 2021 | β |
| The role of HINT1 protein in morphine addiction: An animal model-based study. | Liu P et al. | β | 2021 | β |
| The SEEKING Drive and Its Fixation: A Neuro-Psycho-Evolutionary Approach to the Pathology of Addiction. | Alcaro A et al. | β | 2021 | β |
| Time-dependent changes in striatal monoamine levels and gene expression following single and repeated amphetamine administration in rats. | Sequeira-Cordero A et al. | β | 2021 | β |
| Value-based cognition and drug dependency. | Loganathan K | β | 2021 | β |
| 4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels. | Abiero A et al. | β | 2020 | β |
| Abuse potential and toxicity of the synthetic cathinones (i.e., "Bath salts"). | Riley AL et al. | β | 2020 | β |
| Alpha-1 Adrenergic Receptors Modulate Glutamate and GABA Neurotransmission onto Ventral Tegmental Dopamine Neurons during Cocaine Sensitization. | Velasquez-Martinez MC et al. | β | 2020 | β |
| A New Look at an Old Drug: Cumulative Effects of Low Ribavirin Doses in Amphetamine-Sensitized Rats. | PetkoviΔ B et al. | β | 2020 | β |
| Choice is relative: Reinforcing value of food and activity in obesity treatment. | Carr KA et al. | β | 2020 | β |
| Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorder. | PetkoviΔ B et al. | β | 2020 | β |
| Cross-generational THC Exposure Weakly Attenuates Cocaine's Rewarding Effects in Adult Male Offspring. | Hempel BJ et al. | β | 2020 | β |
| Cross-reinstatement between 3,4-methylenedioxypyrovalerone (MDPV) and cocaine using conditioned place preference. | Duart-Castells L et al. | β | 2020 | β |
| Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors. | Escobar ADP et al. | β | 2020 | β |
| Deep brain stimulation of the infralimbic cortex attenuates cocaine priming-induced reinstatement of drug seeking. | Guercio LA et al. | β | 2020 | β |
| Dopamine Receptor DRD2 Gene rs1076560, Personality Traits and Anxiety in the Polysubstance Use Disorder. | Suchanecka A et al. | β | 2020 | β |
| Effect of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide on Acquisition and Expression of Nicotine-Induced Behavioral Sensitization and Striatal Adenosine Levels. | Ur Rehman N et al. | β | 2020 | β |
| Effects of a trace amine-associated receptor 1 agonist RO 5263397 on ethanol-induced behavioral sensitization. | Wu R et al. | β | 2020 | β |
| Effects of Ethanol Exposure During Adolescence or Adulthood on Locomotor Sensitization and Dopamine Levels in the Reward System. | Carrara-Nascimento PF et al. | β | 2020 | β |
| Enriched Environment Ameliorates Cognitive Deficits and Locomotor Sensitization in Morphine-Withdrawn Rats Receiving Methadone Maintenance Treatment. | Akbari P et al. | β | 2020 | β |
| Environmental enrichment reduces behavioural sensitization in mice previously exposed to toluene: The role of D1 receptors. | PΓ‘ez-MartΓnez N et al. | β | 2020 | β |
| Exposure to Commercial Cigarette Smoke Produces Psychomotor Sensitization Via Hyperstimulation of Glutamate Response in the Dorsal Striatum. | Ryu IS et al. | β | 2020 | β |
| Functional and Dysfunctional Neuroplasticity in Learning to Cope with Stress. | Cabib S et al. | β | 2020 | β |
| Ifenprodil Attenuates Methamphetamine-Induced Behavioral Sensitization Through the GluN2B-PP2A-AKT Cascade in the Dorsal Striatum of Mice. | Chen G et al. | β | 2020 | β |
| Improving translation of animal models of addiction and relapse by reverse translation. | Venniro M et al. | β | 2020 | β |
| Individual Differences in Amphetamine Locomotor Sensitization are Accompanied with Changes in Dopamine Release and Firing Pattern in the Dorsolateral Striatum of Rats. | Gatica RI et al. | β | 2020 | β |
| Insights into the Neurobiology of Craving in Opioid Use Disorder. | Lueptow LM et al. | β | 2020 | β |
| Involvement of dopamine D3 receptor and dopamine transporter in methamphetamine-induced behavioral sensitization in tree shrews. | Huang J et al. | β | 2020 | β |
| Ketamine sensitization: Influence of dose, environment, social isolation and treatment interval. | Trujillo KA et al. | β | 2020 | β |
| Locomotor effects of 3,4-methylenedioxymethamphetamine (MDMA) and its deuterated form in mice: psychostimulant effects, stereotypy, and sensitization. | Berquist MD et al. | β | 2020 | β |
| Possible Role of CRF-Hcrt Interaction in the Infralimbic Cortex in the Emergence and Maintenance of Compulsive Alcohol-Seeking Behavior. | Kim JS et al. | β | 2020 | β |
| Profiling of behavioral effects evoked by ketamine and the role of 5HT<sub>2</sub> and D<sub>2</sub> receptors in ketamine-induced locomotor sensitization in mice. | Galvanho JP et al. | β | 2020 | β |
| Reduced expression of ethanol sensitization by Ξ±3Ξ²4 nicotinic acetylcholine receptors in DBA/2J mice. | Miller CN et al. | β | 2020 | β |
| Resting-state effective connectivity in the motive circuit of methamphetamine users: A case controlled fMRI study. | Mansoory MS et al. | β | 2020 | β |
| Social Isolation in Male Rats During Adolescence Inhibits the Wnt/Ξ²-Catenin Pathway in the Prefrontal Cortex and Enhances Anxiety and Cocaine-Induced Plasticity in Adulthood. | Cuesta S et al. | β | 2020 | β |
| The Brain Emotional Systems in Addictions: From Attachment to Dominance/Submission Systems. | Giacolini T et al. | β | 2020 | β |
| The non-receptor tyrosine kinase Pyk2 modulates acute locomotor effects of cocaine in D1 receptor-expressing neurons of the nucleus accumbens. | de Pins B et al. | β | 2020 | β |
| The potent psychomotor, rewarding and reinforcing properties of 3-fluoromethamphetamine in rodents. | Ryu IS et al. | β | 2020 | β |
| The role of DNA methyltransferase activity in cocaine treatment and withdrawal in the nucleus accumbens of mice. | Urb M et al. | β | 2020 | β |
| The role of nicotinic acetylcholine receptors in alcohol-related behaviors. | Miller CN et al. | β | 2020 | β |
| The roles of cannabinoid CB1 and CB2 receptors in cocaine-induced behavioral sensitization and conditioned place preference in mice. | Lopes JB et al. | β | 2020 | β |
| Acute and repeated administration of MDPV increases aggressive behavior in mice: forensic implications. | De-Giorgio F et al. | β | 2019 | β |
| Agmatine Inhibits Behavioral Sensitization to Ethanol Through Imidazoline Receptors. | Taksande BG et al. | β | 2019 | β |
| An Assessment between D1 Receptor Agonist and D2 receptor Antagonist into the Ventral Tegmental Area on Conditioned Place Preference and Locomotor Activity. | Ahmadian SM et al. | β | 2019 | β |
| A Neurobehavioral Approach to Addiction: Implications for the Opioid Epidemic and the Psychology of Addiction. | Bechara A et al. | β | 2019 | β |
| Are All Dopamine Agonists Essentially the Same? | Torti M et al. | β | 2019 | β |
| Behavioral and Noradrenergic Sensitizations in Vulnerable Traumatized Rats Suggest Common Bases with Substance Use Disorders. | Le Dorze C et al. | β | 2019 | β |
| Cocaine withdrawal reduces GABA<sub>B</sub> R transmission at entopeduncular nucleus - lateral habenula synapses. | Tan D et al. | β | 2019 | β |
| Consequence of Two Protocols of Social Defeat Stress on Nicotine-Induced Psychomotor Effects in Mice. | Domingues LP et al. | β | 2019 | β |
| Dopaminergic Effects of Major Bath Salt Constituents 3,4-Methylenedioxypyrovalerone (MDPV), Mephedrone, and Methylone Are Enhanced Following Co-exposure. | Allen SA et al. | β | 2019 | β |
| Effects of adenosine A<sub>2A</sub> receptor antagonists on cocaine-induced locomotion and cocaine seeking. | Haynes NS et al. | β | 2019 | β |
| Enduring effects of juvenile social isolation on physiological properties of medium spiny neurons in nucleus accumbens. | Zhang XQ et al. | β | 2019 | β |
| Fish oil treatment reduces chronic alcohol exposure induced synaptic changes. | Shi Z et al. | β | 2019 | β |
| Growth hormone secretagogue receptor signalling affects high-fat intake independently of plasma levels of ghrelin and LEAP2, in a 4-day binge eating model. | Cornejo MP et al. | β | 2019 | β |
| Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex. | Miranda MendonΓ§a AP et al. | β | 2019 | β |
| Identifying Triggers of Alcohol Craving to Develop Effective Virtual Environments for Cue Exposure Therapy. | GhiΕ£Δ A et al. | β | 2019 | β |
| Inhibitory regulation of the prefrontal cortex following behavioral sensitization to amphetamine and/or methamphetamine psychostimulants: A review of GABAergic mechanisms. | Wearne TA et al. | β | 2019 | β |
| Omega-3 decreases D1 and D2 receptors expression in the prefrontal cortex and prevents amphetamine-induced conditioned place preference in rats. | Metz VG et al. | β | 2019 | β |
| Opioid system modulators buprenorphine and samidorphan alter behavior and extracellular neurotransmitter concentrations in the Wistar Kyoto rat. | Smith KL et al. | β | 2019 | β |
| Oxytocin prevents the increase of cocaine-related responses produced by social defeat. | Ferrer-PΓ©rez C et al. | β | 2019 | β |
| Post Traumatic Stress Disorder and Substance Use Disorder as Two Pathologies Affecting Memory Reactivation: Implications for New Therapeutic Approaches. | Gisquet-Verrier P et al. | β | 2019 | β |
| Prepulse Inhibition of the Startle Reflex as a Predictor of Vulnerability to Develop Locomotor Sensitization to Cocaine. | Arenas MC et al. | β | 2019 | β |
| Selective dopamine D3 receptor antagonist YQA14 inhibits morphine-induced behavioral sensitization in wild type, but not in dopamine D3 receptor knockout mice. | Lv Y et al. | β | 2019 | β |
| Sensitization to the prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA). | Curry DW et al. | β | 2019 | β |
| Sex- and dose-dependent abuse liability of repeated subanesthetic ketamine in rats. | Schoepfer KJ et al. | β | 2019 | β |
| Substitution therapy with amphetamine-isotherapic attenuates amphetamine toxicological aspects of addiction. | Segat HJ et al. | β | 2019 | β |
| The undeveloped properties of GABA neurons in the ventral tegmental area promote energy intake for growth in juvenile rats. | Maejima Y et al. | β | 2019 | β |
| Abstinence to chronic methamphetamine switches connectivity between striatal, hippocampal and sensorimotor regions and increases cerebral blood volume response. | Choi JK et al. | β | 2018 | β |
| Antagonism of corticotropin-releasing factor CRF<sub>1</sub> receptors blocks the enhanced response to cocaine after social stress. | Ferrer-PΓ©rez C et al. | β | 2018 | β |
| Associations Between the Dopamine D4 Receptor and DAT1 Dopamine Transporter Genes Polymorphisms and Personality Traits in Addicted Patients. | Chmielowiec J et al. | β | 2018 | β |
| Balance of Go1Ξ± and Go2Ξ± expression regulates motor function via the striatal dopaminergic system. | Baron J et al. | β | 2018 | β |
| Central nervous system neuroplasticity and the sensitization of hypertension. | Johnson AK et al. | β | 2018 | β |
| Cocaine-Evoked Locomotor Activity Negatively Correlates With the Expression of Neuromedin U Receptor 2 in the Nucleus Accumbens. | Kasper JM et al. | β | 2018 | β |
| Cocaine increases dopaminergic connectivity in the nucleus accumbens. | Dos Santos M et al. | β | 2018 | β |
| Cocaine-induced locomotor sensitization associates with slow oscillatory firing of neurons in the ventral tegmental area. | Liu CL et al. | β | 2018 | β |
| Dentate gyrus neurogenesis ablation via cranial irradiation enhances morphine self-administration and locomotor sensitization. | Bulin SE et al. | β | 2018 | β |
| Drug Seeking and Relapse: New Evidence of a Role for Orexin and Dynorphin Co-transmission in the Paraventricular Nucleus of the Thalamus. | Matzeu A et al. | β | 2018 | β |
| Effects of Oral Calcium Dosage and Timing on Ethanol-Induced Sensitization of Locomotion in DBA/2 Mice. | Shimizu C et al. | β | 2018 | β |
| Effects of repeated cocaine administration on dopamine D1 receptor modulation of mesocorticolimbic GABA and glutamate transmission. | Steketee JD et al. | β | 2018 | β |
| Enkephalin as a Pivotal Player in Neuroadaptations Related to Psychostimulant Addiction. | Mongi-Bragato B et al. | β | 2018 | β |
| Ghrelin Recruits Specific Subsets of Dopamine and GABA Neurons of Different Ventral Tegmental Area Sub-nuclei. | Cornejo MP et al. | β | 2018 | β |
| High Throughput Measurement of Locomotor Sensitization to Volatilized Cocaine in <i>Drosophila melanogaster</i>. | FiloΕ‘eviΔ A et al. | β | 2018 | β |
| Inhibitory Plasticity of Mesocorticolimbic Circuits in Addiction and Mental Illness. | Ostroumov A et al. | β | 2018 | β |
| Kinase interest you in treating incubated cocaine-craving? A hypothetical model for treatment intervention during protracted withdrawal from cocaine. | Szumlinski KK et al. | β | 2018 | β |
| Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons. | Runegaard AH et al. | β | 2018 | β |
| MHC class I in dopaminergic neurons suppresses relapse to reward seeking. | Murakami G et al. | β | 2018 | β |
| Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity. | Klawonn AM et al. | β | 2018 | β |
| Neurobiology of Propofol Addiction and Supportive Evidence: What Is the New Development? | Xiong M et al. | β | 2018 | β |
| Opioid and Psychostimulant Plasticity: Targeting Overlap in Nucleus Accumbens Glutamate Signaling. | Hearing M et al. | β | 2018 | β |
| PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis. | Jensen KL et al. | β | 2018 | β |
| Regulator of G protein signaling-12 modulates the dopamine transporter in ventral striatum and locomotor responses to psychostimulants. | Gross JD et al. | β | 2018 | β |
| Repeated Administration of Cigarette Smoke Condensate Increases Glutamate Levels and Behavioral Sensitization. | Ryu IS et al. | β | 2018 | β |
| Repeated restraint stress reduces the acquisition and relapse of methamphetamine-conditioned place preference but not behavioral sensitization. | Seo JY et al. | β | 2018 | β |
| Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking. | Parrilla-Carrero J et al. | β | 2018 | β |
| Role of orexin-1 receptors in the dorsal hippocampus (CA1 region) in expression and extinction of the morphine-induced conditioned place preference in the rats. | Farahimanesh S et al. | β | 2018 | β |
| Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder. | Lisieski MJ et al. | β | 2018 | β |
| Social Influences in Animal Models of Opiate Addiction. | Tomek SE et al. | β | 2018 | β |
| Sugar Addiction: From Evolution to Revolution. | Wiss DA et al. | β | 2018 | β |
| Toll-like receptor 3 modulates the behavioral effects of cocaine in mice. | Zhu R et al. | β | 2018 | β |
| Adenylyl Cyclase 1 Is Required for Ethanol-Induced Locomotor Sensitization and Associated Increases in NMDA Receptor Phosphorylation and Function in the Dorsal Medial Striatum. | Bosse KE et al. | β | 2017 | β |
| A novel synthetic cathinone, 2-(methylamino)-1-(naphthalen-2-yl) propan-1-one (BMAPN), produced rewarding effects and altered striatal dopamine-related gene expression in mice. | Botanas CJ et al. | β | 2017 | β |
| Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine. | Su LY et al. | β | 2017 | β |
| Behavioral changes after nicotine challenge are associated with Ξ±7 nicotinic acetylcholine receptor-stimulated glutamate release in the rat dorsal striatum. | Ryu IS et al. | β | 2017 | β |
| Brain molecular changes and behavioral alterations induced by propofol anesthesia exposure in peripubertal rats. | PavkoviΔ Ε½ et al. | β | 2017 | β |
| Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders. | Lee JLC et al. | β | 2017 | β |
| Chemogenetic inhibition reveals midline thalamic nuclei and thalamo-accumbens projections mediate cocaine-seeking in rats. | Wunsch AM et al. | β | 2017 | β |
| Chronic oral methylphenidate treatment reversibly increases striatal dopamine transporter and dopamine type 1 receptor binding in rats. | Robison LS et al. | β | 2017 | β |
| Cocaine sensitization increases subthreshold activity in dopamine neurons from the ventral tegmental area. | Arencibia-Albite F et al. | β | 2017 | β |
| Corticotropin-Releasing Factor (CRF) and Addictive Behaviors. | Roberto M et al. | β | 2017 | β |
| Effect of optogenetic manipulation of accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization. | Kang BJ et al. | β | 2017 | β |
| Effects of Repeated Ethanol Exposures on NMDA Receptor Expression and Locomotor Sensitization in Mice Expressing Ethanol Resistant NMDA Receptors. | den Hartog CR et al. | β | 2017 | β |
| Ghrelin receptor antagonism of morphine-induced conditioned place preference and behavioral and accumbens dopaminergic sensitization in rats. | Jerabek P et al. | β | 2017 | β |
| Impact of Early Consumption of High-Fat Diet on the Mesolimbic Dopaminergic System. | Naneix F et al. | β | 2017 | β |
| Intramuscular Route of Administration Increases Potency in Eliciting Cocaine-Induced Behavioral Sensitization. | Rice BA et al. | β | 2017 | β |
| Is Addiction a Brain Disease? | Berridge KC | β | 2017 | β |
| Locomotor activity: A distinctive index in morphine self-administration in rats. | Zhang JJ et al. | β | 2017 | β |
| Locomotor sensitization to intermittent ketamine administration is associated with nucleus accumbens plasticity in male and female rats. | Strong CE et al. | β | 2017 | β |
| Morphine treatment enhances glutamatergic input onto neurons of the nucleus accumbens via both disinhibitory and stimulating effect. | Yuan K et al. | β | 2017 | β |
| Perinatal protein deprivation facilitates morphine cross-sensitization to cocaine and enhances ΞFosB expression in adult rats. | Perondi MC et al. | β | 2017 | β |
| Regulation of BAZ1A and nucleosome positioning in the nucleus accumbens in response to cocaine. | Sun H et al. | β | 2017 | β |
| Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors. | Voyer D et al. | β | 2017 | β |
| Role of Wnt/Ξ²-catenin pathway in the nucleus accumbens in long-term cocaine-induced neuroplasticity: a possible novel target for addiction treatment. | Cuesta S et al. | β | 2017 | β |
| Social factors affect motor and anxiety behaviors in the animal model of attention-deficit hyperactivity disorders: A housing-style factor. | Tsai ML et al. | β | 2017 | β |
| Stereoselective Differences between the Reinforcing and Motivational Effects of Cathinone-Derived 4-Methylmethcathinone (Mephedrone) In Self-Administering Rats. | Philogene-Khalid HL et al. | β | 2017 | β |
| The abuse potential of two novel synthetic cathinones with modification on the alpha-carbon position, 2-cyclohexyl-2-(methylamino)-1-phenylethanone (MACHP) and 2-(methylamino)-1-phenyloctan-1-one (MAOP), and their effects on dopaminergic activity. | Botanas CJ et al. | β | 2017 | β |
| The expression of amphetamine sensitization is dissociable from anxiety and aversive memory: Effect of an acute injection of amphetamine. | Gatica RI et al. | β | 2017 | β |
| The new kisspeptin derivative - kissorphin (KSO) - attenuates acute hyperlocomotion and sensitization induced by ethanol and morphine in mice. | Gibula-Bruzda E et al. | β | 2017 | β |
| Vesicular acetylcholine transporter (VAChT) over-expression induces major modifications of striatal cholinergic interneuron morphology and function. | Janickova H et al. | β | 2017 | β |
| Wnt/Ξ²-catenin pathway in the prefrontal cortex is required for cocaine-induced neuroadaptations. | Cuesta S et al. | β | 2017 | β |
| Ξ±3Ξ²4 nicotinic receptors in the medial habenula and substance P transmission in the interpeduncular nucleus modulate nicotine sensitization. | Eggan BL et al. | β | 2017 | β |
| Activation of serotonin 5-HT(2C) receptor suppresses behavioral sensitization and naloxone-precipitated withdrawal symptoms in morphine-dependent mice. | Zhang G et al. | β | 2016 | β |
| Adolescent D-amphetamine treatment in a rodent model of ADHD: Pro-cognitive effects in adolescence without an impact on cocaine cue reactivity in adulthood. | Jordan CJ et al. | β | 2016 | β |
| An Update on CRF Mechanisms Underlying Alcohol Use Disorders and Dependence. | Quadros IM et al. | β | 2016 | β |
| A selective D3 receptor antagonist YQA14 attenuates methamphetamine-induced behavioral sensitization and conditioned place preference in mice. | Sun L et al. | β | 2016 | β |
| Behavioral sensitization of the reinforcing value of food: What food and drugs have in common. | Temple JL | β | 2016 | β |
| Behavioral sensitization to ethanol: Neural basis and factors that influence its acquisition and expression. | Camarini R et al. | β | 2016 | β |
| Cell-Type Specific Insertion of GluA2-Lacking AMPARs with Cocaine Exposure Leading to Sensitization, Cue-Induced Seeking, and Incubation of Craving. | Terrier J et al. | β | 2016 | β |
| Cocaine-induced behavioral sensitization decreases the expression of endocannabinoid signaling-related proteins in the mouse hippocampus. | Blanco E et al. | β | 2016 | β |
| Cocaine-induced neurodevelopmental deficits and underlying mechanisms. | Martin MM et al. | β | 2016 | β |
| Convergence of Reinforcing and Anhedonic Cocaine Effects in the Ventral Pallidum. | Creed M et al. | β | 2016 | β |
| Corticostriatal Afferents Modulate Responsiveness to Psychostimulant Drugs and Drug-Associated Stimuli. | Kerstetter KA et al. | β | 2016 | β |
| Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. | Bell RL et al. | β | 2016 | β |
| Exposure to opiates in female adolescents alters mu opiate receptor expression and increases the rewarding effects of morphine in future offspring. | Vassoler FM et al. | β | 2016 | β |
| Gamma-Aminobutyric Acidergic Projections From the Dorsal Raphe to the Nucleus Accumbens Are Regulated by Neuromedin U. | Kasper JM et al. | β | 2016 | β |
| Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens. | Sustkova-Fiserova M et al. | β | 2016 | β |
| High fat diet augments amphetamine sensitization in mice: Role of feeding pattern, obesity, and dopamine terminal changes. | Fordahl SC et al. | β | 2016 | β |
| Increased context-dependent conditioning to amphetamine in mice lacking TAAR1. | Sukhanov I et al. | β | 2016 | β |
| Liking, wanting, and the incentive-sensitization theory of addiction. | Berridge KC et al. | β | 2016 | β |
| Morphine-induced locomotor sensitization produces structural plasticity in the mesocorticolimbic system dependent on CB1-R activity. | Guegan T et al. | β | 2016 | β |
| Neurochemical substrates of the rewarding effects of MDMA: implications for the development of pharmacotherapies to MDMA dependence. | Roger-SΓ‘nchez C et al. | β | 2016 | β |
| Neurotensin: A role in substance use disorder? | Ferraro L et al. | β | 2016 | β |
| Orexin-A/Hypocretin-1 Mediates Cocaine-Seeking Behavior in the Posterior Paraventricular Nucleus of the Thalamus via Orexin/Hypocretin Receptor-2. | Matzeu A et al. | β | 2016 | β |
| Role of dorsal hippocampal orexin-1 receptors in memory restoration induced by morphine sensitization phenomenon. | Alijanpour S et al. | β | 2016 | β |
| Role of Nitric Oxide on Dopamine Release and Morphine-Dependency. | Motahari AA et al. | β | 2016 | β |
| Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice. | Kolik LG et al. | β | 2016 | β |
| Selective Enhancement of Dopamine Release in the Ventral Pallidum of Methamphetamine-Sensitized Mice. | Stout KA et al. | β | 2016 | β |
| Sensitization to the locomotor stimulant effects of "bath salt" constituents, 4-methylmethcathinone (4-MMC) and 3,4-methylenedioxypyrovalerone (MDPV), in male Sprague-Dawley rats. | Berquist MD et al. | β | 2016 | β |
| Sensitization to the motor stimulant effects of 3,4-methylenedioxypyrovalerone (MDPV) and cross-sensitization to methamphetamine in rats. | Watterson LR et al. | β | 2016 | β |
| Signals from the Fourth Dimension Regulate Drug Relapse. | Mulholland PJ et al. | β | 2016 | β |
| The Effects of 4-Methylethcathinone on Conditioned Place Preference, Locomotor Sensitization, and Anxiety-Like Behavior: A Comparison with Methamphetamine. | Xu P et al. | β | 2016 | β |
| The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis. | Scofield MD et al. | β | 2016 | β |
| The role of adenylyl cyclase in the medial prefrontal cortex in cocaine-induced behavioral sensitization in rats. | Liu K et al. | β | 2016 | β |
| The Ventral Pallidum: Proposed Integrator of Positive and Negative Factors in Cocaine Abuse. | James MH et al. | β | 2016 | β |
| Water deprivation-partial rehydration induces sensitization of sodium appetite and alteration of hypothalamic transcripts. | Pereira-Derderian DT et al. | β | 2016 | β |
| Addiction therapy. Refining deep brain stimulation to emulate optogenetic treatment of synaptic pathology. | Creed M et al. | β | 2015 | β |
| Adolescent exposure to cocaine, amphetamine, and methylphenidate cross-sensitizes adults to methamphetamine with drug- and sex-specific effects. | Shanks RA et al. | β | 2015 | β |
| AMN082, a metabotropic glutamate receptor 7 allosteric agonist, attenuates locomotor sensitization and cross-sensitization induced by cocaine and morphine in mice. | Jenda M et al. | β | 2015 | β |
| Amphetamine sensitization is accompanied by an increase in prelimbic cortex activity. | Aguilar-Rivera MI et al. | β | 2015 | β |
| Attention deficit hyperactivity disorder and substance misuse: an evaluation of causal hypotheses and treatment considerations. | Young S et al. | β | 2015 | β |
| Basal anxiety negatively correlates with vulnerability to ethanol-induced behavioral sensitization in DBA/2J mice: modulation by diazepam. | Botia B et al. | β | 2015 | β |
| Cocaine enhances the conditioned rewarding effects of MDMA in adolescent mice. | Aguilar MA et al. | β | 2015 | β |
| Cocaine-induced locomotor sensitization in rats correlates with nucleus accumbens activity on manganese-enhanced MRI. | Perrine SA et al. | β | 2015 | β |
| Deficits in behavioral sensitization and dopaminergic responses to methamphetamine in adenylyl cyclase 1/8-deficient mice. | Bosse KE et al. | β | 2015 | β |
| Differential effects of cocaine exposure on the abundance of phospholipid species in rat brain and blood. | Cummings BS et al. | β | 2015 | β |
| Effects of consuming a diet high in fat and/or sugar on the locomotor effects of acute and repeated cocaine in male and female C57BL/6J mice. | Collins GT et al. | β | 2015 | β |
| Effects of high-frequency stimulation of the nucleus accumbens on the development and expression of ethanol sensitization in mice. | Nona CN et al. | β | 2015 | β |
| Effects of nicotine on ethanol-induced locomotor sensitization: A model of neuroadaptation. | Gubner NR et al. | β | 2015 | β |
| Effects of rimonabant on the development of single dose-induced behavioral sensitization to ethanol, morphine and cocaine in mice. | Marinho EA et al. | β | 2015 | β |
| Endogenous cholinergic neurotransmission contributes to behavioral sensitization to morphine. | Bajic D et al. | β | 2015 | β |
| Escalation in high fat intake in a binge eating model differentially engages dopamine neurons of the ventral tegmental area and requires ghrelin signaling. | Valdivia S et al. | β | 2015 | β |
| Extra (non-contingent) food does not affect behavioral tolerance to d-amphetamine's rate-decreasing effects. | Krebs CA et al. | β | 2015 | β |
| GABAB receptors as a therapeutic strategy in substance use disorders: focus on positive allosteric modulators. | Filip M et al. | β | 2015 | β |
| GIRK Channel Plasticity and Implications for Drug Addiction. | Marron Fernandez de Velasco E et al. | β | 2015 | β |
| L-Dopa Stimulates Cortisol Secretion through Adrenocorticotropic Hormone Release in Short Children. | Marakaki C et al. | β | 2015 | β |
| Long-term behavioral effects in a rat model of prolonged postnatal morphine exposure. | Craig MM et al. | β | 2015 | β |
| Memory impairment and alterations in prefrontal cortex gamma band activity following methamphetamine sensitization. | Janetsian SS et al. | β | 2015 | β |
| Methyl supplementation attenuates cocaine-seeking behaviors and cocaine-induced c-Fos activation in a DNA methylation-dependent manner. | Wright KN et al. | β | 2015 | β |
| Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine. | Yohn NL et al. | β | 2015 | β |
| Peripherally Restricted Cannabinoids for the Treatment of Pain. | Romero-Sandoval EA et al. | β | 2015 | β |
| Serotonergic Systems in the Pathophysiology of Ethanol Dependence: Relevance to Clinical Alcoholism. | Marcinkiewcz CA | β | 2015 | β |
| Single prolonged stress effects on sensitization to cocaine and cocaine self-administration in rats. | Eagle AL et al. | β | 2015 | β |
| Stress-induced sensitization: the hypothalamic-pituitary-adrenal axis and beyond. | Belda X et al. | β | 2015 | β |
| Survival Analysis of Drug Abuse Relapse in Addiction Treatment Centers. | Kassani A et al. | β | 2015 | β |
| Temporal and dose-dependent differences in simultaneously-induced cocaine hypervigilance and conditioned-place-preference in marmoset monkeys. | Borges AC et al. | β | 2015 | β |
| The affective dimension of pain as a risk factor for drug and alcohol addiction. | LeBlanc DM et al. | β | 2015 | β |
| The basolateral amygdala in reward learning and addiction. | Wassum KM et al. | β | 2015 | β |
| The dopamine D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization. | Shen MY et al. | β | 2015 | β |
| The ins and outs of the striatum: role in drug addiction. | Yager LM et al. | β | 2015 | β |
| The Involvement of Norepinephrine in Behaviors Related to Psychostimulant Addiction. | Zaniewska M et al. | β | 2015 | β |
| Thymoquinone Inhibition of Acquisition and Expression of Alcohol-Induced Behavioral Sensitization. | Khan MS et al. | β | 2015 | β |
| Using DREADDs to investigate addiction behaviors. | Ferguson SM et al. | β | 2015 | β |
| Altered NMDA receptor subunit gene expression in brains of mice showing high vs. low sensitization to ethanol. | Nona CN et al. | β | 2014 | β |
| A novel dopamine D3 receptor antagonist YQA14 inhibits methamphetamine self-administration and relapse to drug-seeking behaviour in rats. | Chen Y et al. | β | 2014 | β |
| Behavioral effects of endogenous or exogenous estradiol and progesterone on cocaine sensitization in female rats. | Souza MF et al. | β | 2014 | β |
| Chemical stimulation of the lateral hypothalamus potentiated the sensitization to morphine in rats: involvement of orexin-1 receptor in the ventral tegmental area. | Razavi Y et al. | β | 2014 | β |
| Cocaine exposure prior to pregnancy alters the psychomotor response to cocaine and transcriptional regulation of the dopamine D1 receptor in adult male offspring. | Sasaki A et al. | β | 2014 | β |
| Cocaine-induced behavioral sensitization is associated with changes in the expression of endocannabinoid and glutamatergic signaling systems in the mouse prefrontal cortex. | Blanco E et al. | β | 2014 | β |
| Cocaine induces DNA damage in distinct brain areas of female rats under different hormonal conditions. | de Souza MF et al. | β | 2014 | β |
| Comprehensive analysis of transcription dynamics from brain samples following behavioral experience. | Turm H et al. | β | 2014 | β |
| Corticotropin releasing factor: a key role in the neurobiology of addiction. | Zorrilla EP et al. | β | 2014 | β |
| Distinct behavioral phenotypes in ethanol-induced place preference are associated with different extinction and reinstatement but not behavioral sensitization responses. | Pildervasser JV et al. | β | 2014 | β |
| Effects of the trace amine associated receptor 1 agonist RO5263397 on abuse-related behavioral indices of methamphetamine in rats. | Jing L et al. | β | 2014 | β |
| Effects of the trace amine-associated receptor 1 agonist RO5263397 on abuse-related effects of cocaine in rats. | Thorn DA et al. | β | 2014 | β |
| Effects of varenicline on ethanol-induced conditioned place preference, locomotor stimulation, and sensitization. | Gubner NR et al. | β | 2014 | β |
| Enhanced upregulation of CRH mRNA expression in the nucleus accumbens of male rats after a second injection of methamphetamine given thirty days later. | Cadet JL et al. | β | 2014 | β |
| Estrogen receptors mediate estradiol's effect on sensitization and CPP to cocaine in female rats: role of contextual cues. | Segarra AC et al. | β | 2014 | β |
| Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways. | Gelernter J et al. | β | 2014 | β |
| Implication of NMDA receptors in behavioural sensitization to psychostimulants: a short review. | Landa L et al. | β | 2014 | β |
| Individual differences in ethanol locomotor sensitization are associated with dopamine D1 receptor intra-cellular signaling of DARPP-32 in the nucleus accumbens. | Abrahao KP et al. | β | 2014 | β |
| Inhibition of PKC disrupts addiction-related memory. | Howell KK et al. | β | 2014 | β |
| In vivo amphetamine action is contingent on Ξ±CaMKII. | Steinkellner T et al. | β | 2014 | β |
| Methamphetamine modulates glutamatergic synaptic transmission in rat primary cultured hippocampal neurons. | Zhang S et al. | β | 2014 | β |
| Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors. | Mahler SV et al. | β | 2014 | β |
| mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse. | Neasta J et al. | β | 2014 | β |
| Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization. | Song SS et al. | β | 2014 | β |
| Oxytocin via its receptor affects restraint stress-induced methamphetamine CPP reinstatement in mice: Involvement of the medial prefrontal cortex and dorsal hippocampus glutamatergic system. | Han WY et al. | β | 2014 | β |
| Persistent behavioral and neurochemical sensitization to an acute injection of methamphetamine following unpredictable stress. | Matuszewich L et al. | β | 2014 | β |
| Preadolescent drd1-EGFP mice exhibit cocaine-induced behavioral sensitization. | TobΓ³n KE et al. | β | 2014 | β |
| Recent advances with a novel model organism: alcohol tolerance and sensitization in zebrafish (Danio rerio). | Tran S et al. | β | 2014 | β |
| Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake. | Quintanilla ME et al. | β | 2014 | β |
| The adenosine neuromodulation system in schizophrenia. | Rial D et al. | β | 2014 | β |
| The latest achievements in the pharmacotherapy of gambling disorder. | Εabuzek K et al. | β | 2014 | β |
| The paraventricular nucleus of the thalamus is recruited by both natural rewards and drugs of abuse: recent evidence of a pivotal role for orexin/hypocretin signaling in this thalamic nucleus in drug-seeking behavior. | Matzeu A et al. | β | 2014 | β |
| The trace amine associated receptor 1 agonist RO5263397 attenuates the induction of cocaine behavioral sensitization in rats. | Thorn DA et al. | β | 2014 | β |
| The use of virtual reality in craving assessment and cue-exposure therapy in substance use disorders. | Hone-Blanchet A et al. | β | 2014 | β |
| Wheel-running mitigates psychomotor sensitization initiation but not post-sensitization conditioned activity and conditioned place preference induced by cocaine in mice. | Geuzaine A et al. | β | 2014 | β |
| Whole tobacco smoke extracts to model tobacco dependence in animals. | Brennan KA et al. | β | 2014 | β |
| A GΞ±s DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. | Farrell MS et al. | β | 2013 | β |
| Alterations in the striatal dopamine system during intravenous methamphetamine exposure: effects of contingent and noncontingent administration. | LaΔan G et al. | β | 2013 | β |
| Amphetamine-induced sensitization has little effect on multiple learning paradigms and fails to rescue mice with a striatal learning defect. | Eldred KC et al. | β | 2013 | β |
| Amphetamine locomotor sensitization is accompanied with an enhanced high KβΊ-stimulated Dopamine release in the rat medial prefrontal cortex. | Casanova JP et al. | β | 2013 | β |
| Behavioral metabolomics analysis identifies novel neurochemical signatures in methamphetamine sensitization. | Adkins DE et al. | β | 2013 | β |
| Blockade of ethanol-induced behavioral sensitization by sodium butyrate: descriptive analysis of gene regulations in the striatum. | Legastelois R et al. | β | 2013 | β |
| Ceftriaxone attenuates locomotor activity induced by acute and repeated cocaine exposure in mice. | Tallarida CS et al. | β | 2013 | β |
| Cocaine-induced behavioral sensitization in mice: effects of microinjection of dopamine d2 receptor antagonist into the nucleus accumbens. | Jung ES et al. | β | 2013 | β |
| Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin. | Feng YM et al. | β | 2013 | β |
| Different patterns of administration modulate propensity of methadone and buprenorphine to promote locomotor sensitization in mice. | Allouche S et al. | β | 2013 | β |
| Dopamine signaling in food addiction: role of dopamine D2 receptors. | Baik JH | β | 2013 | β |
| Dopamine signaling in reward-related behaviors. | Baik JH | β | 2013 | β |
| Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbens. | Ma YY et al. | β | 2013 | β |
| D-Serine facilitates the effectiveness of extinction to reduce drug-primed reinstatement of cocaine-induced conditioned place preference. | Hammond S et al. | β | 2013 | β |
| Dual role of PPAR-Ξ³ in induction and expression of behavioral sensitization to cannabinoid receptor agonist WIN55,212-2. | Enayatfard L et al. | β | 2013 | β |
| Effects of sodium butyrate on methamphetamine-sensitized locomotor activity. | Harkness JH et al. | β | 2013 | β |
| Enhancement of behavioral sensitization, anxiety-like behavior, and hippocampal and frontal cortical CREB levels following cocaine abstinence in mice exposed to cocaine during adolescence. | Valzachi MC et al. | β | 2013 | β |
| Erratum: Drug-primed reinstatement of cocaine seeking in mice: increased excitability of mediumsized spiny neurons in the nucleus accumbens. | Ma YY et al. | β | 2013 | β |
| Expression of behavioral sensitization to ethanol is increased by energy drink administration. | Ferreira SE et al. | β | 2013 | β |
| Ghrelin and ghrelin receptor modulation of psychostimulant action. | Wellman PJ et al. | β | 2013 | β |
| Lesion of olfactory epithelium attenuates expression of morphine-induced behavioral sensitization and reinstatement of drug-primed conditioned place preference in mice. | Niu H et al. | β | 2013 | β |
| Locomotor sensitization to ethanol impairs NMDA receptor-dependent synaptic plasticity in the nucleus accumbens and increases ethanol self-administration. | Abrahao KP et al. | β | 2013 | β |
| Mephedrone (4-methylmethcathinone), a principal constituent of psychoactive bath salts, produces behavioral sensitization in rats. | Gregg RA et al. | β | 2013 | β |
| Mephedrone interactions with cocaine: prior exposure to the 'bath salt' constituent enhances cocaine-induced locomotor activation in rats. | Gregg RA et al. | β | 2013 | β |
| Methamphetamine-induced behavioral sensitization in a rodent model of posttraumatic stress disorder. | Eagle AL et al. | β | 2013 | β |
| Modeling relapse in animals. | Martin-Fardon R et al. | β | 2013 | β |
| Multigenerational effects of adolescent morphine exposure on dopamine D2 receptor function. | Byrnes JJ et al. | β | 2013 | β |
| Netrin-1 receptor-deficient mice show age-specific impairment in drug-induced locomotor hyperactivity but still self-administer methamphetamine. | Kim JH et al. | β | 2013 | β |
| Nicotine-, tobacco particulate matter- and methamphetamine-produced locomotor sensitisation in rats. | Brennan KA et al. | β | 2013 | β |
| Novel technology for modulating locomotor activity as an operant response in the mouse: implications for neuroscience studies involving "exercise" in rodents. | Fantegrossi WE et al. | β | 2013 | β |
| Pharmacosynthetics: Reimagining the pharmacogenetic approach. | Farrell MS et al. | β | 2013 | β |
| Rats classified as low or high cocaine locomotor responders: a unique model involving striatal dopamine transporters that predicts cocaine addiction-like behaviors. | Yamamoto DJ et al. | β | 2013 | β |
| Repeated cocaine weakens GABA(B)-Girk signaling in layer 5/6 pyramidal neurons in the prelimbic cortex. | Hearing M et al. | β | 2013 | β |
| Retraining the addicted brain: a review of hypothesized neurobiological mechanisms of mindfulness-based relapse prevention. | Witkiewitz K et al. | β | 2013 | β |
| Serotonin2C receptors and drug addiction: focus on cocaine. | Devroye C et al. | β | 2013 | β |
| Stimulant treatment for attention-deficit hyperactivity disorder and risk of developing substance use disorder. | Groenman AP et al. | β | 2013 | β |
| Susceptibility to ethanol sensitization is differentially associated with changes in pCREB, trkB and BDNF mRNA expression in the mouse brain. | Nona CN et al. | β | 2013 | β |
| Sustained impairment of Ξ±2A-adrenergic autoreceptor signaling mediates neurochemical and behavioral sensitization to amphetamine. | Doucet EL et al. | β | 2013 | β |
| Testing the nanoparticle-allostatic cross-adaptation-sensitization model for homeopathic remedy effects. | Bell IR et al. | β | 2013 | β |
| The role of L-type calcium channels in the development and expression of behavioral sensitization to ethanol. | Broadbent J | β | 2013 | β |
| Transforming growth factor beta receptor 1 is increased following abstinence from cocaine self-administration, but not cocaine sensitization. | Gancarz-Kausch AM et al. | β | 2013 | β |
| Behavioral sensitization to ethanol results in cross-sensitization to MK-801 but not to NMDA administered intra-accumbens. | Abrahao KP et al. | β | 2012 | β |
| Cannabinoid CB1 receptors mediate the effects of corticotropin-releasing factor on the reinstatement of cocaine seeking and expression of cocaine-induced behavioural sensitization. | Kupferschmidt DA et al. | β | 2012 | β |
| Central dopaminergic system and its implications in stress-mediated neurological disorders and gastric ulcers: short review. | Rasheed N et al. | β | 2012 | β |
| Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system. | Hearing MC et al. | β | 2012 | β |
| Differential action of methamphetamine on tyrosine hydroxylase and dopamine transport in the nigrostriatal pathway of ΞΌ-opioid receptor knockout mice. | Park SW et al. | β | 2012 | β |
| Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions. | Durieux PF et al. | β | 2012 | β |
| Disulfiram stimulates dopamine release from noradrenergic terminals and potentiates cocaine-induced dopamine release in the prefrontal cortex. | Devoto P et al. | β | 2012 | β |
| Eating high fat chow enhances the locomotor-stimulating effects of cocaine in adolescent and adult female rats. | Baladi MG et al. | β | 2012 | β |
| Electroacupuncture suppresses discrete cue-evoked heroin-seeking and fos protein expression in the nucleus accumbens core in rats. | Liu S et al. | β | 2012 | β |
| Examination of a role for metabotropic glutamate receptor 5 in the medial prefrontal cortex in cocaine sensitization in rats. | Timmer KM et al. | β | 2012 | β |
| Expression of ethanol-induced behavioral sensitization is associated with alteration of chromatin remodeling in mice. | Botia B et al. | β | 2012 | β |
| Insights to drug addiction derived from ultrastructural views of the mesocorticolimbic system. | Morales M et al. | β | 2012 | β |
| Investigation of the neuroanatomical substrates of reward seeking following protracted abstinence in mice. | Madsen HB et al. | β | 2012 | β |
| Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation. | Lisek R et al. | β | 2012 | β |
| Multiple roles for orexin/hypocretin in addiction. | Mahler SV et al. | β | 2012 | β |
| Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions. | Feduccia AA et al. | β | 2012 | β |
| Orexin/hypocretin (Orx/Hcrt) transmission and drug-seeking behavior: is the paraventricular nucleus of the thalamus (PVT) part of the drug seeking circuitry? | Martin-Fardon R et al. | β | 2012 | β |
| Pharmacokinetic strategies for treatment of drug overdose and addiction. | Gorelick DA | β | 2012 | β |
| Pharmacological and genetic interventions in serotonin (5-HT)(2C) receptors to alter drug abuse and dependence processes. | Filip M et al. | β | 2012 | β |
| Pharmacologically-mediated reactivation and reconsolidation blockade of the psychostimulant-abuse circuit: a novel treatment strategy. | Lee TH et al. | β | 2012 | β |
| Repeated cocaine administration in marmoset monkeys induces hypervigilance-related behaviors, but no changes in locomotion and cortisol levels. | Cagni P et al. | β | 2012 | β |
| The glial cell modulators, ibudilast and its amino analog, AV1013, attenuate methamphetamine locomotor activity and its sensitization in mice. | Snider SE et al. | β | 2012 | β |
| The hypocretin/orexin system: implications for drug reward and relapse. | Plaza-Zabala A et al. | β | 2012 | β |
| Methamphetamine-induced changes in the striatal dopamine pathway in ΞΌ-opioid receptor knockout mice. | Park SW et al. | β | 2011 | β |
| Reinforcement pathology and obesity. | Carr KA et al. | β | 2011 | β |
| Repeated exposure to cocaine alters medial prefrontal cortex dopamine Dβ-like receptor modulation of glutamate and dopamine neurotransmission within the mesocorticolimbic system. | Liu K et al. | β | 2011 | β |