Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and Tobago.
- Authors
- Moore, Shelley; Montane-Jaime, L K; Carr, Lucinda G; Ehlers, Cindy L
- Year
- 2007
- Journal
- Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism
- PMID
- 17718398
- PMCID
- PMC3860431
The population of Trinidad and Tobago is composed mainly of people of East Indian (Indo-Trinidadians) and African (Afro-Trinidadians) ancestry. Differences in alcoholism rates exist between these two ethnic groups, and researchers have investigated whether these differences can be explained in part by variations in the genes encoding the alcohol-metabolizing enzymes alcohol dehydrogenase (ADH) 1B and 1C, and aldehyde dehydrogenase (ALDH) 1 and 2. Studies have demonstrated that a certain variant of the gene encoding ADH1B (ADH1B*3) is associated with a reduced risk of alcoholism in Afro-Trinidadians, as is a variant of the gene encoding ADH1C (i.e., ADH1C*1) in Indo-Trinidadians. An ALDH2 variant shown to have protective effects primarily in East Asians was not found in either Trinidadian ethnic group. However, a variant in the gene encoding cytosolic ALDH1A (i.e. ALDH1A1*1/*2) was found to be associated with an increase in alcohol dependence in Indo-Trinidadians.
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| Name | Type |
|---|---|
| acetaldehyde | drug |
| acetic acid | drug |
| ADH | gene |
| ADH1B | gene |
| ADH1C | gene |
| African American | cohort |
| Afro-Trinidadian participants local | cohort |
| Afro-Trinidadians local | cohort |
| alcohol | phenotype |
| alcohol dependence | phenotype |
| alcoholic liver disease | phenotype |
| alcohol-induced flushing | phenotype |
| Alcohol-induced liver disease local | phenotype |
| alcoholism | phenotype |
| alcohol metabolism | phenotype |
| Alcohol-related disabilities local | phenotype |
| Alcohol Use Disorder | phenotype |
| ALDH1A1 | gene |
| ALDH2 | gene |
| Alkaline phosphatase local | drug |
| Aspartate aminotransferase local | phenotype |
| control subjects | cohort |
| CYP2E1 | gene |
| East Asian | cohort |
| East Indian ancestry local | cohort |
| ethnic groups | cohort |
| Far East Asian descent local | cohort |
| flushing | phenotype |
| Gamma-glutamyltransferase local | drug |
| Genes involved in alcohol metabolism local | gene |
| heavy drinking | phenotype |
| increased level of response to alcohol local | phenotype |
| Indo-Trinidadian participants local | cohort |
| Indo-Trinidadians local | cohort |
| Liver function tests local | phenotype |
| lower rates of alcoholism local | phenotype |
| lower rates of alcohol use local | phenotype |
| Trinidad and Tobago island population local | cohort |
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| The genetics of substance dependence. | 2012 | 22703173 |
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|---|---|---|---|---|
| Alcohol use, heavy episodic drinking, and associated cardiovascular risk in Guyana. | Motilal MS et al. | — | 2025 | → |
| The Promise of Genetics in Alcohol Use Disorders and the Problems of Phenotype, Polygenetic Architecture, Ancestry, and Comorbidity. | Ehlers CL et al. | — | 2025 | → |
| National Alcohol Survey of households in Trinidad and Tobago (NASHTT): Alcohol use in households. | Maharaj RG et al. | — | 2017 | → |
| Subjective response to alcohol and ADH polymorphisms in a select sample of young adult male East Indians and Africans in Trinidad and Tobago. | Montane Jaime LK et al. | — | 2014 | → |
| Drug and alcohol use by homicide victims in Trinidad and Tobago, 2001-2007. | Kuhns JB et al. | — | 2012 | → |
| The genetics of substance dependence. | Wang JC et al. | — | 2012 | → |
| Co-morbidity of alcohol dependence and select affective and anxiety disorders among individuals of East Indian and African ancestry in Trinidad and Tobago. | Shafe S et al. | — | 2009 | → |
| Alcohol and the liver. | Reuben A | — | 2008 | → |
| The clinical course of alcoholism in Trinidad and Tobago. | Montane-Jaime LK et al. | — | 2008 | → |