The role of acetaldehyde in upper digestive tract cancer in alcoholics.
paper
Cited
Public
Unavailable
- Authors
- Seitz, Helmut K; Meier, Patrick
- Year
- 2007
- Journal
- Translational research : the journal of laboratory and clinical medicine
- PMID
- 17543846
- DOI
- 10.1016/j.trsl.2006.12.002
Chronic excessive alcohol consumption is the strongest risk factor for upper aerodigestive tract (UADT) cancer. Multiple mechanisms are involved in alcohol-associated cancer development of the UADT, including acetaldehyde (AA) effects. AA is toxic, mutagenic, and carcinogenic. Evidence of the role of AA in alcohol-associated carcinogenesis derived from genetic linkage studies in alcoholics. Polymorphism or mutation in genes coding for AA generation or detoxification enzymes are associated with increased cancer risk. It has been clearly shown in Asians that individuals carrying the acetaldehyde dehydrogenase 2*2 (ALDH2*2) allele have a significantly increased cancer risk when they consume alcohol. In Caucasians, alcohol dehydrogenase 1*1 (ADH1C*1) allele encodes for an alcohol dehydrogenase (ADH) isoenzyme, which produces 2.5 times more AA than the corresponding allele ADH1C*2. The authors found that the ADH1C*1 allele frequency and rate of homozygosity was significantly associated with an increased risk for alcohol-related cancer. AA seems to be an important factor in alcohol-associated carcinogenesis of the UADT.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genetics and alcoholism. | 2013 | 23712313 |
| Genes encoding enzymes involved in ethanol metabolism. | 2012 | 23134050 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Modulatory effects of CNNM4 on protein- l -isoaspartyl- O -methyltransferase repair function during alcohol-induced hepatic damage. | GonzΓ‘lez-Recio I et al. | β | 2025 | β |
| Folic acid: friend or foe in cancer therapy. | Thabet RH et al. | β | 2024 | β |
| Alcohol use disorder, neuroinflammation, and intake of dietary fibers: a new approach for treatment. | PΓ©rez-Reytor D et al. | β | 2023 | β |
| Pretreatment elevated mean corpuscular volume as an indicator for high risk esophageal second primary cancer in patients with head and neck cancer. | Tsushima N et al. | β | 2023 | β |
| The Impact of Alcohol Consumption and Oral Microbiota on Upper Aerodigestive Tract Carcinomas: A Pilot Study. | Fiore M et al. | β | 2023 | β |
| Can gene therapy be used to prevent cancer? Gene therapy for aldehyde dehydrogenase 2 deficiency. | Montel RA et al. | β | 2022 | β |
| Hepatoprotective effects of sea cucumber ether-phospholipids against alcohol-induced lipid metabolic dysregulation and oxidative stress in mice. | Wang X et al. | β | 2022 | β |
| Kinetic modeling of malondialdehyde reactivity in oil to simulate actual malondialdehyde formation upon lipid oxidation. | Vandemoortele A et al. | β | 2021 | β |
| Molecular Mechanisms of Alcohol-Induced Colorectal Carcinogenesis. | Johnson CH et al. | β | 2021 | β |
| Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules. | BerrΓos-CΓ‘rcamo P et al. | β | 2020 | β |
| Role of Base Excision Repair Pathway in the Processing of Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugs. | Baiken Y et al. | β | 2020 | β |
| Systemic Adeno-Associated Virus-Mediated Gene Therapy Prevents the Multiorgan Disorders Associated with Aldehyde Dehydrogenase 2 Deficiency and Chronic Ethanol Ingestion. | Matsumura Y et al. | β | 2020 | β |
| An integrative bioinformatics pipeline to demonstrate the alteration of the interaction between the ALDH2*2 allele with NAD<sup>+</sup> and Disulfiram. | J CP et al. | β | 2019 | β |
| Implications of the mitochondrial interactome of mammalian thioredoxin 2 for normal cellular function and disease. | Chasapis CT et al. | β | 2019 | β |
| Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice. | De Logu F et al. | β | 2019 | β |
| Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population. | Lee YA et al. | β | 2019 | β |
| Genetic variants of <i>ALDH2</i>-rs671 and <i>CYP2E1</i>-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population. | Ye X et al. | β | 2018 | β |
| Human Endogenous Formaldehyde as an Anticancer Metabolite: Its Oxidation Downregulation May Be a Means of Improving Therapy. | Dorokhov YL et al. | β | 2018 | β |
| Alcohol dehydrogenase and aldehyde dehydrogenase in malignant neoplasms. | Orywal K et al. | β | 2017 | β |
| Alcohol metabolism and oesophageal cancer: a systematic review of the evidence. | Matejcic M et al. | β | 2017 | β |
| Deuterium-reinforced polyunsaturated fatty acids improve cognition in a mouse model of sporadic Alzheimer's disease. | Elharram A et al. | β | 2017 | β |
| Hepatic transcriptomic alterations for N,N-dimethyl-p-toluidine (DMPT) and p-toluidine after 5-day exposure in rats. | Dunnick JK et al. | β | 2017 | β |
| Lifestyle Risk Factors for Serrated Colorectal Polyps: AΒ Systematic Review and Meta-analysis. | Bailie L et al. | β | 2017 | β |
| Polymorphisms in ADH1B and ALDH2 genes associated with the increased risk of gastric cancer in West Bengal, India. | Ghosh S et al. | β | 2017 | β |
| Reactivity of Free Malondialdehyde during In Vitro Simulated Gastrointestinal Digestion. | Vandemoortele A et al. | β | 2017 | β |
| Thiophene bridged aldehydes (TBAs) image ALDH activity in cells <i>via</i> modulation of intramolecular charge transfer. | Maity S et al. | β | 2017 | β |
| Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis. | Cai Q et al. | β | 2015 | β |
| Ethanol enhances arsenic-induced cyclooxygenase-2 expression via both NFAT and NF-ΞΊB signalings in colorectal cancer cells. | Wang L et al. | β | 2015 | β |
| Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo. | Chen CH et al. | β | 2015 | β |
| Alcoholic beverages and carbonated soft drinks: consumption and gastrointestinal cancer risks. | Cuomo R et al. | β | 2014 | β |
| Pathogenesis of alcoholic liver disease: role of oxidative metabolism. | Ceni E et al. | β | 2014 | β |
| Targeting aldehyde dehydrogenase 2: new therapeutic opportunities. | Chen CH et al. | β | 2014 | β |
| Effect of overexpression of human aldehyde dehydrogenase 2 in LLC-PK1 cells on glyceryl trinitrate biotransformation and cGMP accumulation. | D'Souza Y et al. | β | 2013 | β |
| Genetics and alcoholism. | Edenberg HJ et al. | β | 2013 | β |
| In vivo measurement of aldehyde dehydrogenase-2 activity in rat liver ethanol model using dynamic MRSI of hyperpolarized [1-(13) C]pyruvate. | Josan S et al. | β | 2013 | β |
| Polymorphisms in alcohol metabolism genes ADH1B and ALDH2, alcohol consumption and colorectal cancer. | Crous-Bou M et al. | β | 2013 | β |
| ADH1C Ile350Val polymorphism and cancer risk: evidence from 35 case-control studies. | Xue Y et al. | β | 2012 | β |
| Alcohol intake and folate antagonism via CYP2E1 and ALDH1: effects on oral carcinogenesis. | Hwang PH et al. | β | 2012 | β |
| Dietary, lifestyle and clinicopathological factors associated with APC mutations and promoter methylation in colorectal cancers from the EPIC-Norfolk study. | Gay LJ et al. | β | 2012 | β |
| Ethanol enhances tumor angiogenesis in vitro induced by low-dose arsenic in colon cancer cells through hypoxia-inducible factor 1 alpha pathway. | Wang L et al. | β | 2012 | β |
| Genes encoding enzymes involved in ethanol metabolism. | Hurley TD et al. | β | 2012 | β |
| Changes in aldehyde dehydrogenase 2 expression in rat blood vessels during glyceryl trinitrate tolerance development and reversal. | D'Souza Y et al. | β | 2011 | β |
| Development of a sensitive long-wavelength fluorogenic probe for nitroreductase: a new fluorimetric indictor for analyte determination by dehydrogenase-coupled biosensors. | Huang HC et al. | β | 2011 | β |
| The burden of cancer attributable to alcohol consumption. | Testino G | β | 2011 | β |
| Acetaldehyde adducts in alcoholic liver disease. | Setshedi M et al. | β | 2010 | β |
| Alcohol and gastrointestinal oncology. | Testino G et al. | β | 2010 | β |
| Alcohol and tobacco use in relation to gastric cancer: a prospective study of men in Shanghai, China. | Moy KA et al. | β | 2010 | β |
| Formation of acetaldehyde-derived DNA adducts due to alcohol exposure. | Yu HS et al. | β | 2010 | β |
| Lifestyle factors and p53 mutation patterns in colorectal cancer patients in the EPIC-Norfolk study. | Park JY et al. | β | 2010 | β |
| Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis. | Lee CH et al. | β | 2009 | β |
| Novel Objective Biomarkers of Alcohol Use: Potential Diagnostic and Treatment Management Tools in Dual Diagnosis Care. | Kalapatapu RK et al. | β | 2009 | β |