De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.
paper
Cited
Public
- Authors
- Kirov, G; Pocklington, A J; Holmans, P; Ivanov, D; Ikeda, M; Ruderfer, D; Moran, J; Chambert, K; Toncheva, D; Georgieva, L; Grozeva, D; Fjodorova, M; Wollerton, R; Rees, E; Nikolov, I; van de Lagemaat, L N; BayΓ©s, A; Fernandez, E; Olason, P I; BΓΆttcher, Y; Komiyama, N H; Collins, M O; Choudhary, J; Stefansson, K; Stefansson, H; Grant, S G N; Purcell, S; Sklar, P; O'Donovan, M C; Owen, M J
- Year
- 2012
- Journal
- Molecular psychiatry
- PMID
- 22083728
- DOI
- 10.1038/mp.2011.154
- PMCID
- PMC3603134
A small number of rare, recurrent genomic copy number variants (CNVs) are known to substantially increase susceptibility to schizophrenia. As a consequence of the low fecundity in people with schizophrenia and other neurodevelopmental phenotypes to which these CNVs contribute, CNVs with large effects on risk are likely to be rapidly removed from the population by natural selection. Accordingly, such CNVs must frequently occur as recurrent de novo mutations. In a sample of 662 schizophrenia proband-parent trios, we found that rare de novo CNV mutations were significantly more frequent in cases (5.1% all cases, 5.5% family history negative) compared with 2.2% among 2623 controls, confirming the involvement of de novo CNVs in the pathogenesis of schizophrenia. Eight de novo CNVs occurred at four known schizophrenia loci (3q29, 15q11.2, 15q13.3 and 16p11.2). De novo CNVs of known pathogenic significance in other genomic disorders were also observed, including deletion at the TAR (thrombocytopenia absent radius) region on 1q21.1 and duplication at the WBS (Williams-Beuren syndrome) region at 7q11.23. Multiple de novos spanned genes encoding members of the DLG (discs large) family of membrane-associated guanylate kinases (MAGUKs) that are components of the postsynaptic density (PSD). Two de novos also affected EHMT1, a histone methyl transferase known to directly regulate DLG family members. Using a systems biology approach and merging novel CNV and proteomics data sets, systematic analysis of synaptic protein complexes showed that, compared with control CNVs, case de novos were significantly enriched for the PSD proteome (P=1.72 Γ 10β»βΆ. This was largely explained by enrichment for members of the N-methyl-D-aspartate receptor (NMDAR) (P=4.24 Γ 10β»βΆ) and neuronal activity-regulated cytoskeleton-associated protein (ARC) (P=3.78 Γ 10β»βΈ) postsynaptic signalling complexes. In an analysis of 18β492 subjects (7907 cases and 10β585 controls), case CNVs were enriched for members of the NMDAR complex (P=0.0015) but not ARC (P=0.14). Our data indicate that defects in NMDAR postsynaptic signalling and, possibly, ARC complexes, which are known to be important in synaptic plasticity and cognition, play a significant role in the pathogenesis of schizophrenia.
Histograms of distributions of z-scores. (a) A suggestive de novo and (b) an ambiguous de novo MeZOD call. Black arrows indicate the position of a parent, and red arrows of a child. The x axis shows the median z-scores for all individuals for a particular copy number variant (CNV) region.
Size of copy number variants (CNVs). KaplanβMeier survival graph for the size of de novo CNVs in cases, Icelandic controls, Bulgarian controls and unaffected siblings of autism probands.25
Disruption of postsynaptic signalling within activity-regulated cytoskeleton-associated protein (ARC) and N-methyl-D-aspartate receptor (NMDAR) complexes by copy number variants (CNVs). ARC and NMDAR bind to diverse structural and signalling molecules forming multiprotein complexes. Functional pathways encoded by these complexes are disrupted by de novo CNVs at multiple levels, as indicated by the purple asterisks (number of asterisks=number of de novos overlapping a gene or gene family). Calcium influx via the NMDAR, modulated by calcium release from internal stores (RYR2), drives downstream pathways whose association with the receptor is mediated by scaffold proteins (DLG1, DLG2, DLGAP1). Multiple pathways converge on ERK kinases (extracellular signal-regulated kinases), a focal point in the regulation of ARC transcription, dendritic localisation and local translation.47 ARC mRNA is transported to sites of synaptic activity in complexes containing CYFIP1, dissociation of which is required for ARC translation.49 CYFIP1 also regulates translation of CAMKII,49 a key component of NMDAR complexes. Although not identified in this study, deletions of synaptic adhesion protein NRXN1 (blue asterisk) have previously been found in schizophrenia.29 CNVs disrupting genes within these same functional pathways have also been identified in autism30(black asterisks).
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| Citation | PMID | DOI | Status |
|---|---|---|---|
| Abi-SaabWMD'SouzaDCMoghaddamBKrystalJHThe NMDA antagonist model for schizophrenia: promise and pitfallsPharmacopsychiatry199831(S 2104109975484110.1055/s-2007-979354 | β | β | β |
| BayΓ©sAvan de LagemaatLNCollinsMOCroningMDRWhittleIRChoudharyJSCharacterization of the proteome, diseases and evolution of the human postsynaptic densityNat Neurosci20111419212117005510.1038/nn.2719PMC3040565 | β | β | β |
| BramhamCAlmeMBittinsMKuipersSNairRPaiBThe Arc of synaptic memoryExp Brain Res20102001251401969084710.1007/s00221-009-1959-2PMC2803749 | β | β | β |
| BundyHStahlDMacCabeJHA systematic review and meta-analysis of the fertility of patients with schizophrenia and their unaffected relativesActa Psychiat Scand2010123981062095827110.1111/j.1600-0447.2010.01623.x | β | β | β |
| CooperGMCoeBPGirirajanSRosenfeldJAVuTHBakerCA copy number variation morbidity map of developmental delayNat Genet2011438388462184178110.1038/ng.909PMC3171215 | β | β | β |
| GlessnerJTReillyMPKimCETakahashiNAlbanoAHouCStrong synaptic transmission impact by copy number variations in schizophreniaProc Natl Acad Sci USA201010710584105892048917910.1073/pnas.1000274107PMC2890845 | β | β | β |
| GrantSGMarshallMCPageKLCumiskeyMAArmstrongJDSynapse proteomics of multiprotein complexes: en route from genes to nervous system diseasesHum Mol Genet200514R225R2341615073910.1093/hmg/ddi330 | β | β | β |
| GrozevaDKirovGIvanovDJonesIRJonesLGreenEKRare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophreniaArch Gen Psychiatry2010673183272036850810.1001/archgenpsychiatry.2010.25PMC4476027 | β | β | β |
| GuilmatreADubourgCMoscaA-LLegallicSGoldenbergADrouin-GarraudVRecurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardationArch Gen Psychiatry2009669479561973635110.1001/archgenpsychiatry.2009.80PMC2958844 | β | β | β |
| HusiHWardMAChoudharyJSBlackstockWPGrantSGNProteomic analysis of NMDA receptor-adhesion protein signaling complexesNat Neurosci200036616691086269810.1038/76615 | β | β | β |
| IkedaMAleksicBKirovGKinoshitaYYamanouchiYKitajimaTCopy number variation in schizophrenia in the Japanese populationBiol Psychiatry2010672832861988009610.1016/j.biopsych.2009.08.034 | β | β | β |
| Ingason ARujescuDCichonSSigurdssonESigmundssonTPietilainenOPHCopy number variations of chromosome 16p13.1 region associated with schizophreniaMol Psychiatry20111617251978696110.1038/mp.2009.101PMC3330746 | β | β | β |
| IngasonAKirovGGieglingIHansenTIslesARJakobsenKDMaternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illnessAm J Psychiatry20111684084172132495010.1176/appi.ajp.2010.09111660PMC3428917 | β | β | β |
| International Schizophrenia Consortium (ISC)Rare chromosomal deletions and duplications increase risk of schizophreniaNature20084552372411866803810.1038/nature07239PMC3912847 | β | β | β |
| KirovGGrozevaDNortonNIvanovDMantripragadaKKHolmansPSupport for the involvement of large CNVs in the pathogenesis of schizophreniaHum Mol Genet200918149715031918168110.1093/hmg/ddp043PMC2664144 | β | β | β |
| KirovGGumusDChenWNortonNGeorgievaLSariMComparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophreniaHum Mol Genet2008174584651798906610.1093/hmg/ddm323 | β | β | β |
| KirovGRujescuDIngasonACollierDAO'DonovanMCOwenMJNeurexin 1 (NRXN1) deletions in schizophreniaSchizophr Bull2009358518541967509410.1093/schbul/sbp079PMC2728827 | β | β | β |
| KirovGThe role of copy number variation in schizophreniaExp Rev Neurotherapeutics201010253210.1586/ern.09.13320021318 | β | β | β |
| KleefstraTvan Zelst-StamsWANillesenWMCormier-DaireVHougeGFouldsNFurther clinical and molecular delineation of the 9q subtelomeric deletion syndrome supports a major contribution of EHMT1 haploinsufficiency to the core phenotypeJ Med Genet2009465986061926473210.1136/jmg.2008.062950 | β | β | β |
| KlopockiESchulzeHStrauGOttC-EHallJTrotierFComplex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndromeAm J Hum Genet2007802322401723612910.1086/510919PMC1785342 | β | β | β |
| KramerJMKochinkeKOortveldMAWMarksHKramerDde JongEKEpigenetic regulation of learning and memory by Drosophila EHMT/G9aPLoS Biol20119e10005692124590410.1371/journal.pbio.1000569PMC3014924 | β | β | β |
| LaursenTMMunk-OlsenTReproductive patterns in psychotic patientsSchizophr Res20101212342402057049110.1016/j.schres.2010.05.018 | β | β | β |
| LevinsonDFDuanJOhSWangKSandersARShiJCopy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplicationsAm J Psychiatry20111683023162128514010.1176/appi.ajp.2010.10060876PMC4441324 | β | β | β |
| MalenkaRCNicollRANMDA-receptor-dependent synaptic plasticity: multiple forms and mechanismsTrends Neurosci199316521527750952310.1016/0166-2236(93)90197-t | β | β | β |
| McCarthySEMakarovVKirovGAddingtonAMMcClellanJYoonSMicroduplications of 16p11.2 are associated with schizophreniaNat Genet200941122312271985539210.1038/ng.474PMC2951180 | β | β | β |
| MitchellKJThe genetics of neurodevelopmental diseaseCur Opin Neurobiol20112119720310.1016/j.conb.2010.08.00920832285 | β | β | β |
| Moreno-De-LucaDMulleJGKaminskyEBSandersSJMyersSMAdamMPDeletion 17q12 is a recurrent copy number variant that confers high risk of autism and schizophreniaAm J Hum Genet2010876186302105571910.1016/j.ajhg.2010.10.004PMC2978962 | β | β | β |
| MulleJGDoddAFMcGrathJAWolyniecPSMitchellAAShettyACMicrodeletions of 3q29 confer high risk for schizophreniaAm J Hum Genet2010872292362069140610.1016/j.ajhg.2010.07.013PMC2917706 | β | β | β |
| NapoliIMercaldoVBoylPPEleuteriBZalfaFDe RubeisSThe fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BPCell2008134104210541880509610.1016/j.cell.2008.07.031 | β | β | β |
| OwenMJCraddockNO'DonovanMCSuggestion of roles for both common and rare risk variants in genome-wide studies of schizophreniaArch Gen Psychiatry2010676676732060344810.1001/archgenpsychiatry.2010.69 | β | β | β |
| PintoDDarvishiKShiXRajanDRiglerDFitzgeraldTComprehensive assessment of array-based platforms and calling algorithms for detection of copy number variantsNat Biotech20112951252010.1038/nbt.1852PMC327058321552272 | β | β | β |
| PintoDPagnamentaATKleiLAnneyRMericoDReganRFunctional impact of global rare copy number variation in autism spectrum disordersNature20104663683722053146910.1038/nature09146PMC3021798 | β | β | β |
| RaychaudhuriSKornJMMcCarrollSAConsortiumTISAltshulerDSklarPAccurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain functionPLoS Genet20106pii:e10010972083858710.1371/journal.pgen.1001097PMC2936523 | β | β | β |
| ReesEMoskvinaVOwenMJO'DonovanMCKirovGDe novo rates and selection of schizophrenia-associated copy number variantsBiol Psychiatryadvance online publication, 18 August 2011[e-pub ahead of print].10.1016/j.biopsych.2011.07.01121855053 | β | β | β |
| RujescuDIngasonACichonSPietilΓ€inenOPBarnesMRToulopoulouTDisruption of the neurexin 1 gene is associated with schizophreniaHum Mol Genet2009189889961894572010.1093/hmg/ddn351PMC2695245 | β | β | β |
| Sanders StephanJErcan-SencicekAGHusVLuoRMurtha MichaelTMoreno-De-LucaDMultiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autismNeuron2011708638852165858110.1016/j.neuron.2011.05.002PMC3939065 | β | β | β |
| SebatJLakshmiBMalhotraDTrogeJLese-MartinCWalshTStrong association of de novo copy number mutations with autismScience20073164454491736363010.1126/science.1138659PMC2993504 | β | β | β |
| SebatJLevyDLMcCarthySERare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disordersTrends Genet2009255285351988395210.1016/j.tig.2009.10.004PMC3351381 | β | β | β |
| StefanssonHRujescuDCichonSPietilainenOPHIngasonASteinbergSLarge recurrent microdeletions associated with schizophreniaNature20084552322361866803910.1038/nature07229PMC2687075 | β | β | β |
| TamGWCRedonRCarterNPGrantSGNThe role of DNA copy number variation in schizophreniaBiol Psychiatry200966100510121974807410.1016/j.biopsych.2009.07.027 | β | β | β |
| TarpeyPParnauJBlowMWoffendinHBignellGCoxCMutations in the DLG3 gene cause nonsyndromic X-linked mental retardationAm J Hum Genet2004753183241518516910.1086/422703PMC1216066 | β | β | β |
| VacicVMcCarthySMalhotraDMurrayFChouH-HPeoplesADuplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophreniaNature20114714995032134676310.1038/nature09884PMC3351382 | β | β | β |
| Van der AaNRoomsLVandeweyerGvan den EndeJReyniersEFicheraMFourteen new cases contribute to the characterization of the 7q11.23 microduplication syndromeEur J Med Genet200952941001924939210.1016/j.ejmg.2009.02.006 | β | β | β |
| WalshTMcClellanJMMcCarthySEAddingtonAMPierceSBCooperGMRare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophreniaScience20083205395431836910310.1126/science.1155174 | β | β | β |
| WangKLiMHadleyDLiuRGlessnerJGrantSFAPennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping dataGenome Res200717166516741792135410.1101/gr.6861907PMC2045149 | β | β | β |
| WilliamsNMZaharievaIMartinALangleyKMantripragadaKFossdalRRare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysisLancet2010376140114082088804010.1016/S0140-6736(10)61109-9PMC2965350 | β | β | β |
| XuBRoosJLLevySvan RensburgEJGogosJAKarayiorgouMStrong association of de novo copy number mutations with sporadic schizophreniaNat Genet2008408808851851194710.1038/ng.162 | β | β | β |
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Antipsychotic Use Among Intellectually Disabled Individuals With Rare Genetic Variants That Confer Risk for Schizophrenia. | Colijn MA | β | 2026 | β |
| Control of microglial dynamics by the Arp2/3 complex and the autism- and schizophrenia-associated protein CYFIP1. | Scott-Solache J et al. | β | 2026 | β |
| Functional implications of polygenic risk for schizophrenia in human neurons. | Michael Deans PJ et al. | β | 2026 | β |
| The Relationship Between Neuromelanin, Glutamate, and GABA in First-Episode Psychosis: A Multimodal Magnetic Resonance Imaging Study. | Reyes-Madrigal F et al. | β | 2026 | β |
| VTA-forebrain connectivity moderates adaptive behavior. | Sinza SI et al. | β | 2026 | β |
| Altered Molecular Composition of a Specific Subset of Prefrontal Cortical Excitatory Synapses in Schizophrenia. | Lorincz A et al. | β | 2025 | β |
| An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function. | Kambali M et al. | β | 2025 | β |
| Behavioral Phenotypes and Comorbidity in 3q29 Deletion Syndrome: Results from the 3q29 Registry. | Pollak RM et al. | β | 2025 | β |
| Changes in degree centrality and its associated genes: A longitudinal study of patients with schizophrenia undergoing pharmacological treatment. | Zhang L et al. | β | 2025 | β |
| DLG2 rs11607886 polymorphism associated with schizophrenia and precuneus functional changes. | Zhu H et al. | β | 2025 | β |
| doc2a and doc2b contribute to locomotor and social behaviors by down-regulating npas4b in zebrafish. | Chi Y et al. | β | 2025 | β |
| Elucidating neuroepigenetic mechanisms to inform targeted therapeutics for brain disorders. | Weekley BH et al. | β | 2025 | β |
| Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans. | Wu X et al. | β | 2025 | β |
| Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects. | Walsh RM et al. | β | 2025 | β |
| Genome-wide association study -Driven drug repositioning for the treatment of insomnia. | Satria RD et al. | β | 2025 | β |
| Genomics of schizophrenia, bipolar disorder and major depressive disorder. | Owen MJ et al. | β | 2025 | β |
| Heterozygosity for neurodevelopmental disorder-associated <i>TRIO</i> variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice. | Ishchenko Y et al. | β | 2025 | β |
| Neuronal Synaptic Communication and Mitochondrial Energetics in Human Health and Disease. | Glausier JR | β | 2025 | β |
| NR3C1-mediated epigenetic regulation suppresses astrocytic immune responses in mice. | Park S et al. | β | 2025 | β |
| Penetrance of Neurodevelopmental Copy Number Variants Is Associated With Variations in Cortical Morphology. | Silva AI et al. | β | 2025 | β |
| Synaptic and Non-Synaptic Functions of PTPRD: A Receptor Tyrosine Phosphatase at the Crossroads of Neural Circuitry and Metabolism. | Kim S et al. | β | 2025 | β |
| SynaptopathyDB integrates synaptic proteomes, genetic and phenotypic data to advance research on nervous system disorders. | Sorokina O et al. | β | 2025 | β |
| Accelerated Cortical Thinning in Schizophrenia Is Associated With Rare and Common Predisposing Variation to Schizophrenia and Neurodevelopmental Disorders. | GonzΓ‘lez-PeΓ±as J et al. | β | 2024 | β |
| A cytoplasmic form of EHMT1N methylates viral proteins to enable inclusion body maturation and efficient viral replication. | Biligiri KK et al. | β | 2024 | β |
| Adaptive behaviour deficits in individuals with 3q29 deletion syndrome. | Pollak RM et al. | β | 2024 | β |
| Advances in the Treatment of Cognitive Impairment in Schizophrenia: Targeting NMDA Receptor Pathways. | Zhang T et al. | β | 2024 | β |
| Beyond IQ: executive function deficits and their relation to functional, clinical, and neuroimaging outcomes in 3q29 deletion syndrome. | Pollak RM et al. | β | 2024 | β |
| Contribution of copy number variants on antipsychotic treatment response in Han Chinese patients with schizophrenia. | Sun Y et al. | β | 2024 | β |
| Copy number deletion of PLA2G4A affects the susceptibility and clinical phenotypes of schizophrenia. | Gao Z et al. | β | 2024 | β |
| Differential effects of cannabis constituents on schizophrenia-related psychosis: a rationale for incorporating cannabidiol into a schizophrenia therapeutic regimen. | Johnson K et al. | β | 2024 | β |
| Differential functional consequences of GRIN2A mutations associated with schizophrenia and neurodevelopmental disorders. | Shepard N et al. | β | 2024 | β |
| Dysfunction of the NMDA Receptor in the Pathophysiology of Schizophrenia and/or the Pathomechanisms of Treatment-Resistant Schizophrenia. | Okubo R et al. | β | 2024 | β |
| FMR1 genetically interacts with DISC1 to regulate glutamatergic synaptogenesis. | Honda T et al. | β | 2024 | β |
| Inhibition of EHMT1/2 rescues synaptic damage and motor impairment in a PD mouse model. | Zhang Z et al. | β | 2024 | β |
| Intellectual Disability and Behavioral Deficits Linked to CYFIP1 Missense Variants Disrupting Actin Polymerization. | Mariano V et al. | β | 2024 | β |
| Mapping proteomic composition of excitatory postsynaptic sites in the cerebellar cortex. | Robinson K et al. | β | 2024 | β |
| Passing the torch: The ascendance of the glutamatergic synapse in the pathophysiology of schizophrenia. | Coyle JT | β | 2024 | β |
| Quantitative proteomics of dorsolateral prefrontal cortex reveals an early pattern of synaptic dysmaturation in children with idiopathic autism. | Fatemi SH et al. | β | 2024 | β |
| Role of estrogen in sex differences in memory, emotion and neuropsychiatric disorders. | Iqbal J et al. | β | 2024 | β |
| Sleep maintains excitatory synapse diversity in the cortex and hippocampus. | Koukaroudi D et al. | β | 2024 | β |
| Structural deviations of the posterior fossa and the cerebellum and their cognitive links in a neurodevelopmental deletion syndrome. | Sefik E et al. | β | 2024 | β |
| The Association of Hippocampal Long-Term Potentiation-Induced Gene Expression with Genetic Risk for Psychosis. | Wellard NL et al. | β | 2024 | β |
| VISTA: an integrated framework for structural variant discovery. | Sarwal V et al. | β | 2024 | β |
| Visual-Motor Integration Deficits in 3q29 Deletion Syndrome. | Pollak RM et al. | β | 2024 | β |
| Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function. | Mastwal S et al. | β | 2023 | β |
| A mild impairment in reversal learning in a bowl-digging substrate deterministic task but not other cognitive tests in the Dlg2+/- rat model of genetic risk for psychiatric disorder. | Griesius S et al. | β | 2023 | β |
| Association between autoimmune diseases of the nervous system and schizophrenia: A systematic review and meta-analysis of cohort studies. | Cao Y et al. | β | 2023 | β |
| Astrocytes as master modulators of neural networks: Synaptic functions and disease-associated dysfunction of astrocytes. | Stogsdill JA et al. | β | 2023 | β |
| A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging. | Falkovich R et al. | β | 2023 | β |
| Canonical and Non-Canonical Antipsychotics' Dopamine-Related Mechanisms of Present and Next Generation Molecules: A Systematic Review on Translational Highlights for Treatment Response and Treatment-Resistant Schizophrenia. | de Bartolomeis A et al. | β | 2023 | β |
| Copy Number Variants Increasing Risk for Schizophrenia: Shared and Distinct Effects on Brain Morphometry and Cognitive Performance. | Caseras X et al. | β | 2023 | β |
| Copy Number Variations and Schizophrenia. | SzecΓ³wka K et al. | β | 2023 | β |
| Copy Number Variations in Neuropsychiatric Disorders. | BΓΌki G et al. | β | 2023 | β |
| Dysfunction of cAMP-Protein Kinase A-Calcium Signaling Axis in Striatal Medium Spiny Neurons: A Role in Schizophrenia and Huntington's Disease Neuropathology. | Fjodorova M et al. | β | 2023 | β |
| Dysregulated Signaling at Postsynaptic Density: A Systematic Review and Translational Appraisal for the Pathophysiology, Clinics, and Antipsychotics' Treatment of Schizophrenia. | de Bartolomeis A et al. | β | 2023 | β |
| Family-based analysis of the contribution of rare and common genetic variants to school performance in schizophrenia. | Rammos A et al. | β | 2023 | β |
| Gene Expression and Epigenetic Regulation in the Prefrontal Cortex of Schizophrenia. | Bilecki W et al. | β | 2023 | β |
| Genetic Influences on Cognitive Dysfunction in Schizophrenia. | Greenwood TA | β | 2023 | β |
| Genome-scale copy number variant analysis in schizophrenia patients and controls from South India. | Singh M et al. | β | 2023 | β |
| Genomic findings in schizophrenia and their implications. | Owen MJ et al. | β | 2023 | β |
| Genomic insights into schizophrenia. | Owen MJ | β | 2023 | β |
| High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly. | Berryer MH et al. | β | 2023 | β |
| Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring. | Kaltsas A et al. | β | 2023 | β |
| Mechanisms of copy number variants in neuropsychiatric disorders: From genes to therapeutics. | Forrest MP et al. | β | 2023 | β |
| Molecular mechanisms of schizophrenia: Insights from human genetics. | Farsi Z et al. | β | 2023 | β |
| Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons. | Zhang S et al. | β | 2023 | β |
| Musculoskeletal phenotypes in 3q29 deletion syndrome. | Pollak RM et al. | β | 2023 | β |
| New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications. | Andreassen OA et al. | β | 2023 | β |
| Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis. | Birtele M et al. | β | 2023 | β |
| Pathway-Based Polygenic Risk Scores for Schizophrenia and Associations With Reported Psychotic-like Experiences and Neuroimaging Phenotypes in the UK Biobank. | Barbu MC et al. | β | 2023 | β |
| Psychosis and autism without functional regression in a patient with Kleefstra syndrome. | Colijn MA et al. | β | 2023 | β |
| Psychosis spectrum illnesses as disorders of prefrontal critical period plasticity. | Vinogradov S et al. | β | 2023 | β |
| Resting-state brain functional alterations and their genetic mechanisms in drug-naive first-episode psychosis. | Li Q et al. | β | 2023 | β |
| Rethinking the First Episode of Schizophrenia: Identifying Convergent Mechanisms During Development and Moving Toward Prediction. | Forsyth JK et al. | β | 2023 | β |
| Role of cryptic rearrangements of human chromosomes in the aetiology of schizophrenia. | Jurisova L et al. | β | 2023 | β |
| Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent <i>NRXN1</i> and <i>ABCB11</i> disruptions. | Maury EA et al. | β | 2023 | β |
| Schizophrenia Polygenic Risk During Typical Development Reflects Multiscale Cortical Organization. | Kirschner M et al. | β | 2023 | β |
| Self-Regulatory Neuronal Mechanisms and Long-Term Challenges in Schizophrenia Treatment. | Markiewicz-Gospodarek A et al. | β | 2023 | β |
| The molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research. | Nakamura T et al. | β | 2023 | β |
| The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia. | Vellucci L et al. | β | 2023 | β |
| The Potential Usefulness of the Expanded Carrier Screening to Identify Hereditary Genetic Diseases: A Case Report from Real-World Data. | Veneruso I et al. | β | 2023 | β |
| Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders. | Ye J et al. | β | 2023 | β |
| Using Nonhuman Primate Models to Reverse-Engineer Prefrontal Circuit Failure Underlying Cognitive Deficits in Schizophrenia. | Chafee MV | β | 2023 | β |
| 14-3-3 Dysfunction in Dorsal Hippocampus CA1 (dCA1) Induces Psychomotor Behavior <i>via</i> a dCA1-Lateral Septum-Ventral Tegmental Area Pathway. | Zhang J et al. | β | 2022 | β |
| Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability. | Caldeira GL et al. | β | 2022 | β |
| A brain atlas of synapse protein lifetime across the mouse lifespan. | Bulovaite E et al. | β | 2022 | β |
| A comprehensive benchmarking of WGS-based deletion structural variant callers. | Sarwal V et al. | β | 2022 | β |
| Actionable Genomics in Clinical Practice: Paradigmatic Case Reports of Clinical and Therapeutic Strategies Based upon Genetic Testing. | Butler MG et al. | β | 2022 | β |
| A Deficiency of the Psychiatric Risk Gene DLG2/PSD-93 Causes Excitatory Synaptic Deficits in the Dorsolateral Striatum. | Yoo T et al. | β | 2022 | β |
| Altered resting-state functional connectivity in hiPSCs-derived neuronal networks from schizophrenia patients. | Puvogel S et al. | β | 2022 | β |
| 'Arc'-hitecture of normal cognitive aging. | Myrum C et al. | β | 2022 | β |
| Autism spectrum disorder symptom expression in individuals with 3q29 deletion syndrome. | Pollak RM et al. | β | 2022 | β |
| Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder. | Waldron S et al. | β | 2022 | β |
| Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics. | Spark DL et al. | β | 2022 | β |
| Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia. | Cuenod M et al. | β | 2022 | β |
| Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms relevant for innovative strategies in treatment-resistant schizophrenia. | de Bartolomeis A et al. | β | 2022 | β |
| CNest: A novel copy number association discovery method uncovers 862 new associations from 200,629 whole-exome sequence datasets in the UK Biobank. | Fitzgerald T et al. | β | 2022 | β |
| Cognitive impairment in psychiatric diseases: Biomarkers of diagnosis, treatment, and prevention. | Wang Y et al. | β | 2022 | β |
| Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder. | Kushima I et al. | β | 2022 | β |
| Disparate insults relevant to schizophrenia converge on impaired spike synchrony and weaker synaptic interactions in prefrontal local circuits. | Zick JL et al. | β | 2022 | β |
| Effects of the Glycine Transporter-1 Inhibitor Iclepertin (BI 425809) on Sensory Processing, Neural Network Function, and Cognition in Animal Models Related to Schizophrenia. | Rosenbrock H et al. | β | 2022 | β |
| Enhancing <i>DLG2</i> Implications in Neuropsychiatric Disorders: Analysis of a Cohort of Eight Patients with 11q14.1 Imbalances. | Bertini V et al. | β | 2022 | β |
| Functional impairment of cortical AMPA receptors in schizophrenia. | Zeppillo T et al. | β | 2022 | β |
| How does genetic variation modify ND-CNV phenotypes? | Dinneen TJ et al. | β | 2022 | β |
| Identification of activity-induced Egr3-dependent genes reveals genes associated with DNA damage response and schizophrenia. | Marballi KK et al. | β | 2022 | β |
| Mapping genomic loci implicates genes and synaptic biology in schizophrenia. | Trubetskoy V et al. | β | 2022 | β |
| Metabolic effects of the schizophrenia-associated 3q29 deletion. | Pollak RM et al. | β | 2022 | β |
| Neurodevelopmental Disorders Associated with PSD-95 and Its Interaction Partners. | Levy AM et al. | β | 2022 | β |
| Neuroimaging Findings in Neurodevelopmental Copy Number Variants: Identifying Molecular Pathways to Convergent Phenotypes. | Silva AI et al. | β | 2022 | β |
| NRSF/REST lies at the intersection between epigenetic regulation, miRNA-mediated gene control and neurodevelopmental pathways associated with Intellectual disability (ID) and Schizophrenia. | Alsaqati M et al. | β | 2022 | β |
| Paternal age and 13 psychiatric disorders in the offspring: a population-based cohort study of 7 million children in Taiwan. | Wang SH et al. | β | 2022 | β |
| Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity. | Griesius S et al. | β | 2022 | β |
| SAPAP Scaffold Proteins: From Synaptic Function to Neuropsychiatric Disorders. | Bai Y et al. | β | 2022 | β |
| Schizophrenia Genomics: Convergence on Synaptic Development, Adult Synaptic Plasticity, or Both? | Hall J et al. | β | 2022 | β |
| Schizophrenia Outside the Brain. | ValenΓ§a AGF et al. | β | 2022 | β |
| Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2. | Pass R et al. | β | 2022 | β |
| The interplay of dopamine metabolism abnormalities and mitochondrial defects in the pathogenesis of schizophrenia. | Xu H et al. | β | 2022 | β |
| The nature of schizophrenia: As broad as it is long. | Owen MJ et al. | β | 2022 | β |
| The regulatory effects of lactic acid on neuropsychiatric disorders. | Chen X et al. | β | 2022 | β |
| Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants. | Sanders B et al. | β | 2022 | β |
| Transcriptomic and Proteomic Analysis of CRISPR/Cas9-Mediated <i>ARC</i>-Knockout HEK293 Cells. | Wang YY et al. | β | 2022 | β |
| Ultrarare Loss-of-Function Mutations in the Genes Encoding the Ionotropic Glutamate Receptors of Kainate Subtypes Associated with Schizophrenia Disrupt the Interaction with PSD95. | Hu TM et al. | β | 2022 | β |
| Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus). | Schmidtke D | β | 2021 | β |
| Allele-specific DNA methylation maps in monozygotic twins discordant for psychiatric disorders reveal that disease-associated switching at the EIPR1 regulatory loci modulates neural function. | Li Q et al. | β | 2021 | β |
| A Neurodevelopment Approach for a Transitional Model of Early Onset Schizophrenia. | De Berardis D et al. | β | 2021 | β |
| Characterization of six CaMKIIΞ± variants found in patients with schizophrenia. | Brown CN et al. | β | 2021 | β |
| Clinical evidence that a dysregulated master neural network modulator may aid in diagnosing schizophrenia. | Nomoto M et al. | β | 2021 | β |
| Comparative Analysis for the Performance of Long-Read-Based Structural Variation Detection Pipelines in Tandem Repeat Regions. | Guo M et al. | β | 2021 | β |
| Copy number variation and neuropsychiatric illness. | Rees E et al. | β | 2021 | β |
| Core transcriptional networks in Williams syndrome: IGF1-PI3K-AKT-mTOR, MAPK and actin signaling at the synapse echo autism. | Dai L et al. | β | 2021 | β |
| De novo variation in bipolar disorder. | Goes FS et al. | β | 2021 | β |
| Detecting rare copy number variants from Illumina genotyping arrays with the CamCNV pipeline: Segmentation ofΒ z-scores improves detection and reliability. | Dennis J et al. | β | 2021 | β |
| Detection of Morphological Abnormalities in Schizophrenia: An Important Step to Identify Associated Genetic Disorders or Etiologic Subtypes. | Priol AC et al. | β | 2021 | β |
| Developmental Profile of Psychiatric Risk Associated With Voltage-Gated Cation Channel Activity. | Clifton NE et al. | β | 2021 | β |
| Difficulties of Prenatal Genetic Counseling for a Subsequent Child in a Family With Multiple Genetic Variations. | Huang TX et al. | β | 2021 | β |
| Directly and Indirectly Targeting the Glycine Modulatory Site to Modulate NMDA Receptor Function to Address Unmet Medical Needs of Patients With Schizophrenia. | Pei JC et al. | β | 2021 | β |
| Dissecting Molecular Genetic Mechanisms of 1q21.1 CNV in Neuropsychiatric Disorders. | Yoon J et al. | β | 2021 | β |
| Downregulation by CNNM2 of ATP5MD expression in the 10q24.32 schizophrenia-associated locus involved in impaired ATP production and neurodevelopment. | Wang Z et al. | β | 2021 | β |
| Evidence for the Association between the Intronic Haplotypes of Ionotropic Glutamate Receptors and First-Episode Schizophrenia. | Hirschfeldova K et al. | β | 2021 | β |
| Exploring the biological role of postzygotic and germinal de novo mutations in ASD. | Alonso-Gonzalez A et al. | β | 2021 | β |
| First episode of psychosis in Kleefstra syndrome: a case report. | De Taevernier C et al. | β | 2021 | β |
| Genetic architecture of schizophrenia: a review of major advancements. | Legge SE et al. | β | 2021 | β |
| Genetic association of FMRP targets with psychiatric disorders. | Clifton NE et al. | β | 2021 | β |
| Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion. | Cleynen I et al. | β | 2021 | β |
| Genetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk. | Dimitriadis SI et al. | β | 2021 | β |
| Genome-wide study of copy number variation implicates multiple novel loci for schizophrenia risk in Han Chinese family trios. | Wu X et al. | β | 2021 | β |
| Hidden Role of Gut Microbiome Dysbiosis in Schizophrenia: Antipsychotics or Psychobiotics as Therapeutics? | Munawar N et al. | β | 2021 | β |
| Implications of germline copy-number variations in psychiatric disorders: review of large-scale genetic studies. | Nakatochi M et al. | β | 2021 | β |
| Mechanisms Underlying the Comorbidity of Schizophrenia and Type 2 Diabetes Mellitus. | Mizuki Y et al. | β | 2021 | β |
| Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4. | Rein B et al. | β | 2021 | β |
| Sarcosine as an add-on treatment to antipsychotic medication for people with schizophrenia: a systematic review and meta-analysis of randomized controlled trials. | Marchi M et al. | β | 2021 | β |
| Sex-specific recombination patterns predict parent of origin for recurrent genomic disorders. | Mosley TJ et al. | β | 2021 | β |
| Somatic copy number variants in neuropsychiatric disorders. | Maury EA et al. | β | 2021 | β |
| Targeting synaptic plasticity in schizophrenia: insights from genomic studies. | Mould AW et al. | β | 2021 | β |
| The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study. | Onwordi EC et al. | β | 2021 | β |
| Visual cortical plasticity and the risk for psychosis: An interim analysis of the North American Prodrome Longitudinal Study. | Jacob MS et al. | β | 2021 | β |
| 16p11.2 Copy Number Variations and Neurodevelopmental Disorders. | Rein B et al. | β | 2020 | β |
| Aberrant Auditory Steady-State Response of Awake Mice After Single Application of the NMDA Receptor Antagonist MK-801 Into the Medial Geniculate Body. | Wang X et al. | β | 2020 | β |
| A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder. | Martin J et al. | β | 2020 | β |
| A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum. | Yoo T et al. | β | 2020 | β |
| A MEG Study of Visual Repetition Priming in Schizophrenia: Evidence for Impaired High-Frequency Oscillations and Event-Related Fields in Thalamo-Occipital Cortices. | Sauer A et al. | β | 2020 | β |
| Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice. | Wang ZJ et al. | β | 2020 | β |
| [A new look at the genetics of neurocognitive deficits in schizophrenia]. | Fedorenko OY et al. | β | 2020 | β |
| Assessment of Potential Clinical Role for Exome Sequencing in Schizophrenia. | Balakrishna T et al. | β | 2020 | β |
| Association test using Copy Number Profile Curves (CONCUR) enhances power in rare copy number variant analysis. | Brucker A et al. | β | 2020 | β |
| A transcriptome-wide association study implicates specific pre- and post-synaptic abnormalities in schizophrenia. | Hall LS et al. | β | 2020 | β |
| Characterization of Single Gene Copy Number Variants in Schizophrenia. | Szatkiewicz JP et al. | β | 2020 | β |
| Cognitive Control Errors in Nonhuman Primates Resembling Those in Schizophrenia Reflect Opposing Effects of NMDA Receptor Blockade on Causal Interactions Between Cells and Circuits in Prefrontal and Parietal Cortices. | Kummerfeld E et al. | β | 2020 | β |
| Contribution of de novo and inherited rare CNVs to very preterm birth. | Wong HS et al. | β | 2020 | β |
| CRISPR-based functional evaluation of schizophrenia risk variants. | Rajarajan P et al. | β | 2020 | β |
| Current understanding on the role of nitric oxide and therapeutic potential of NO supplementation in schizophrenia. | Oh SJ et al. | β | 2020 | β |
| De novo mutations identified by exome sequencing implicate rare missense variants in SLC6A1 in schizophrenia. | Rees E et al. | β | 2020 | β |
| Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype. | Frega M et al. | β | 2020 | β |
| Electoretinographic evidence of retinal ganglion cell-dependent function in schizophrenia. | Moghimi P et al. | β | 2020 | β |
| Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disorders. | Erli F et al. | β | 2020 | β |
| Extracellular vesicles in patients in the acute phase of psychosis and after clinical improvement: an explorative study. | Tunset ME et al. | β | 2020 | β |
| Fifty Years of Research on Schizophrenia: The Ascendance of the Glutamatergic Synapse. | Coyle JT et al. | β | 2020 | β |
| FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability. | Clifton NE et al. | β | 2020 | β |
| Genes regulated by BCL11B during T-cell development are enriched for de novo mutations found in schizophrenia patients. | Fahey L et al. | β | 2020 | β |
| Genetics of Childhood-onset Schizophrenia 2019Β Update. | Forsyth JK et al. | β | 2020 | β |
| Genetics of schizophrenia (Review). | Trifu SC et al. | β | 2020 | β |
| Glutamate in schizophrenia: Neurodevelopmental perspectives and drug development. | Egerton A et al. | β | 2020 | β |
| Impairments in sensory-motor gating and information processing in a mouse model of <i>Ehmt1</i> haploinsufficiency. | Davis BA et al. | β | 2020 | β |
| Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia. | Halvorsen M et al. | β | 2020 | β |
| Interneuron NMDA Receptor Ablation Induces Hippocampus-Prefrontal Cortex Functional Hypoconnectivity after Adolescence in a Mouse Model of Schizophrenia. | Alvarez RJ et al. | β | 2020 | β |
| mGlu5 in GABAergic neurons modulates spontaneous and psychostimulant-induced locomotor activity. | Wu CS et al. | β | 2020 | β |
| Multiple Rare Risk Coding Variants in Postsynaptic Density-Related Genes Associated With Schizophrenia Susceptibility. | Hu TM et al. | β | 2020 | β |
| NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models. | Singh MD et al. | β | 2020 | β |
| Rare copy number variants in individuals at clinical high risk for psychosis: Enrichment of synaptic/brain-related functional pathways. | Jagannath V et al. | β | 2020 | β |
| The proteome and its dynamics: A missing piece for integrative multi-omics in schizophrenia. | Borgmann-Winter KE et al. | β | 2020 | β |
| Transcriptome analysis of fibroblasts from schizophrenia patients reveals differential expression of schizophrenia-related genes. | Etemadikhah M et al. | β | 2020 | β |
| Translating insights from neuropsychiatric genetics and genomics for precision psychiatry. | Rees E et al. | β | 2020 | β |
| Two Thalamic Regions Screened Using Laser Capture Microdissection with Whole Human Genome Microarray in Schizophrenia Postmortem Samples. | Bakshi K et al. | β | 2020 | β |
| A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data. | Wang Q et al. | β | 2019 | β |
| A critical review of zebrafish schizophrenia models: Time for validation? | Gawel K et al. | β | 2019 | β |
| Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) regulates anxiety- and novelty-related behaviors. | Penrod RD et al. | β | 2019 | β |
| A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort. | Koromina M et al. | β | 2019 | β |
| Analysis of 15q11.2 CNVs in an Indian population with schizophrenia. | Saxena S et al. | β | 2019 | β |
| Assessment of somatic single-nucleotide variation in brain tissue of cases with schizophrenia. | Fullard JF et al. | β | 2019 | β |
| A weighted burden test using logistic regression for integrated analysis of sequence variants, copy number variants and polygenic risk score. | Curtis D | β | 2019 | β |
| Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia. | Gusev FE et al. | β | 2019 | β |
| Comparative Study of ROCK1 and ROCK2 in Hippocampal Spine Formation and Synaptic Function. | Yan J et al. | β | 2019 | β |
| Damaging coding variants within kainate receptor channel genes are enriched in individuals with schizophrenia, autism and intellectual disabilities. | Koromina M et al. | β | 2019 | β |
| Developmental Exposure to Psychostimulant Primes Activity-dependent Gene Induction in Frontal Cortex. | Ye Y et al. | β | 2019 | β |
| Developmental Genes and Regulatory Proteins, Domains of Cognitive Impairment in Schizophrenia Spectrum Psychosis and Implications for Antipsychotic Drug Discovery: The Example of Dysbindin-1 Isoforms and Beyond. | Waddington JL et al. | β | 2019 | β |
| Differential expression of DLG1 as a common trait in different human diseases: an encouraging issue in molecular pathology. | Marziali F et al. | β | 2019 | β |
| Disturbed Prefrontal Cortex Activity in the Absence of Schizophrenia-Like Behavioral Dysfunction in <i>Arc/Arg3.1</i> Deficient Mice. | Gao X et al. | β | 2019 | β |
| Endophenotypes in Schizophrenia: Digging Deeper to Identify Genetic Mechanisms. | Greenwood TA et al. | β | 2019 | β |
| Enrichment of rare genetic variants in astrocyte gene enriched co-expression modules altered in postmortem brain samples of schizophrenia. | GonzΓ‘lez-PeΓ±as J et al. | β | 2019 | β |
| Essential genetic findings in neurodevelopmental disorders. | Cardoso AR et al. | β | 2019 | β |
| Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. | Huckins LM et al. | β | 2019 | β |
| Genetics of Eating Disorders: What the Clinician Needs to Know. | Bulik CM et al. | β | 2019 | β |
| Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study. | Greenwood TA et al. | β | 2019 | β |
| Glutamate hypothesis in schizophrenia. | Uno Y et al. | β | 2019 | β |
| GWAS of Behavioral Traits. | Mehta D et al. | β | 2019 | β |
| In-silico investigation of coding variants potentially affecting the functioning of the glutamatergic N-methyl-D-aspartate receptor in schizophrenia. | Tsavou A et al. | β | 2019 | β |
| JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk. | Openshaw RL et al. | β | 2019 | β |
| <i>Cyfip1</i> Haploinsufficiency Does Not Alter GABA<sub>A</sub> Receptor Ξ΄-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV<sup>+</sup> Interneurons and Granule Cells. | Trent S et al. | β | 2019 | β |
| Mega-analysis of Odds Ratio: A Convergent Method for a Deep Understanding of the Genetic Evidence in Schizophrenia. | Jia P et al. | β | 2019 | β |
| Microduplications at the 15q11.2 BP1-BP2 locus are enriched in patients with anorexia nervosa. | Chang X et al. | β | 2019 | β |
| Neuropsychiatric phenotypes and a distinct constellation of ASD features in 3q29 deletion syndrome: results from the 3q29 registry. | Pollak RM et al. | β | 2019 | β |
| Novel Complex Interactions between Mitochondrial and Nuclear DNA in Schizophrenia and Bipolar Disorder. | Schulmann A et al. | β | 2019 | β |
| Psychiatric disorders in children with 16p11.2 deletion and duplication. | Niarchou M et al. | β | 2019 | β |
| Psychopharmacology and Psychotherapy Research. | Kim K et al. | β | 2019 | β |
| Region-specific inhibition of 14-3-3 proteins induces psychomotor behaviors in mice. | Graham K et al. | β | 2019 | β |
| Somatic mutations in the human brain: implications for psychiatric research. | Nishioka M et al. | β | 2019 | β |
| Synapse diversity and synaptome architecture in human genetic disorders. | Grant SGN | β | 2019 | β |
| Synergistic effects of common schizophrenia risk variants. | Schrode N et al. | β | 2019 | β |
| Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis. | Rees E et al. | β | 2019 | β |
| Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene. | Bodkin JA et al. | β | 2019 | β |
| Temporal dynamics of miRNAs in human DLPFC and its association with miRNA dysregulation in schizophrenia. | Hu Z et al. | β | 2019 | β |
| The genetics of neuropsychiatric disorders. | Bray NJ et al. | β | 2019 | β |
| Top-Down Suppression of Sensory Cortex in an NMDAR Hypofunction Model of Psychosis. | Ranson A et al. | β | 2019 | β |
| Abnormalities in behaviour, histology and prefrontal cortical gene expression profiles relevant to schizophrenia in embryonic day 17 MAM-Exposed C57BL/6 mice. | Huo C et al. | β | 2018 | β |
| A Genetic Study of Psychosis in Huntington's Disease: Evidence for the Involvement of Glutamate Signaling Pathways. | Tsuang DW et al. | β | 2018 | β |
| A Longitudinal Imaging Genetics Study of Neuroanatomical Asymmetry in Alzheimer's Disease. | Wachinger C et al. | β | 2018 | β |
| An opposing function of paralogs in balancing developmental synapse maturation. | Favaro PD et al. | β | 2018 | β |
| Arc protein: a flexible hub for synaptic plasticity and cognition. | Nikolaienko O et al. | β | 2018 | β |
| Arc ubiquitination in synaptic plasticity. | Mabb AM et al. | β | 2018 | β |
| Association of copy number variation across the genome with neuropsychiatric traits in the general population. | Guyatt AL et al. | β | 2018 | β |
| Blocking NMDAR Disrupts Spike Timing and Decouples Monkey Prefrontal Circuits: Implications for Activity-Dependent Disconnection in Schizophrenia. | Zick JL et al. | β | 2018 | β |
| Brain Organoids: Expanding Our Understanding of Human Development and Disease. | Chuye LB et al. | β | 2018 | β |
| Cognitive development prior to onset of psychosis. | Mollon J et al. | β | 2018 | β |
| Common and Rare Genetic Risk Factors Converge in Protein Interaction Networks Underlying Schizophrenia. | Chang X et al. | β | 2018 | β |
| Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. | PardiΓ±as AF et al. | β | 2018 | β |
| Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights. | Kushima I et al. | β | 2018 | β |
| Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling. | Schijven D et al. | β | 2018 | β |
| Construction of an Exome-Wide Risk Score for Schizophrenia Based on a Weighted Burden Test. | Curtis D | β | 2018 | β |
| Defects in Bioenergetic Coupling in Schizophrenia. | Sullivan CR et al. | β | 2018 | β |
| Dendritic structural plasticity and neuropsychiatric disease. | Forrest MP et al. | β | 2018 | β |
| Dlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability. | Coba MP et al. | β | 2018 | β |
| Effects of common GRM5 genetic variants on cognition, hippocampal volume and mGluR5 protein levels in schizophrenia. | Matosin N et al. | β | 2018 | β |
| Exome-wide analysis of mutational burden in patients with typical and atypical Rolandic epilepsy. | Bobbili DR et al. | β | 2018 | β |
| Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. | Sundararajan T et al. | β | 2018 | β |
| Genetic Overlap Between Schizophrenia and Volumes of Hippocampus, Putamen, and Intracranial Volume Indicates Shared Molecular Genetic Mechanisms. | Smeland OB et al. | β | 2018 | β |
| Genetic variability in scaffolding proteins and risk for schizophrenia and autism-spectrum disorders: a systematic review. | Soler J et al. | β | 2018 | β |
| Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan. | Chen SP et al. | β | 2018 | β |
| Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes. | Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium. Electronic address: douglas.ruderfer@vanderbilt.edu et al. | β | 2018 | β |
| High Incidence of Copy Number Variants in Adults with Intellectual Disability and Co-morbid Psychiatric Disorders. | ViΓ±as-Jornet M et al. | β | 2018 | β |
| Identification of a novel Dlg2 isoform differentially expressed in IFNΞ²-producing plasmacytoid dendritic cells. | Ali S et al. | β | 2018 | β |
| Immediate Early Genes Anchor a Biological Pathway of Proteins Required for Memory Formation, Long-Term Depression and Risk for Schizophrenia. | Marballi KK et al. | β | 2018 | β |
| Induced Pluripotent Stem Cells Reveal Common Neurodevelopmental Genome Deprograming in Schizophrenia. | Narla ST et al. | β | 2018 | β |
| Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder. | Takata A et al. | β | 2018 | β |
| Inverse synaptic tagging: An inactive synapse-specific mechanism to capture activity-induced Arc/arg3.1 and to locally regulate spatial distribution of synaptic weights. | Okuno H et al. | β | 2018 | β |
| Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes. | Grochowski CM et al. | β | 2018 | β |
| Mechanistic insights into the genetics of affective psychosis from Prader-Willi syndrome. | Aman LCS et al. | β | 2018 | β |
| Mitochondrial Complex I Deficiency in Schizophrenia and Bipolar Disorder and Medication Influence. | Rollins BL et al. | β | 2018 | β |
| Neurodevelopmental synaptopathies: Insights from behaviour in rodent models of synapse gene mutations. | Luo J et al. | β | 2018 | β |
| Noise-robust assessment of SNP array based CNV calls through local noise estimation of log R ratios. | Cosemans N et al. | β | 2018 | β |
| Overexpression of LINE-1 Retrotransposons in Autism Brain. | Shpyleva S et al. | β | 2018 | β |
| Polygenic risk score for schizophrenia is not strongly associated with the expression of specific genes or gene sets. | Curtis D | β | 2018 | β |
| Postsynaptic density proteins and their involvement in neurodevelopmental disorders. | Kaizuka T et al. | β | 2018 | β |
| Proteomic analysis of postsynaptic proteins in regions of the human neocortex. | Roy M et al. | β | 2018 | β |
| Psychodynamic Psychiatry, the Biopsychosocial Model, and the Difficult Patient. | Plakun EM | β | 2018 | β |
| Rare Risk Variants Identification by Identity-by-Descent Mapping and Whole-Exome Sequencing Implicates Neuronal Development Pathways in Schizophrenia and Bipolar Disorder. | Salvoro C et al. | β | 2018 | β |
| Recent Advances in the Genetics of Schizophrenia. | Avramopoulos D | β | 2018 | β |
| Roles for Arc in metabotropic glutamate receptor-dependent LTD and synapse elimination: Implications in health and disease. | Wilkerson JR et al. | β | 2018 | β |
| Setting the stage for a role of the postsynaptic proteome in inherited neurometabolic disorders. | BayΓ©s Γ | β | 2018 | β |
| Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models. | Taoufik E et al. | β | 2018 | β |
| Synaptic proteomics as a means to identify the molecular basis of mental illness: Are we getting there? | Reig-Viader R et al. | β | 2018 | β |
| The effect of ketamine on the consolidation and extinction of contextual fear memory. | Clifton NE et al. | β | 2018 | β |
| The joint impact of cognitive performance in adolescence and familial cognitive aptitude on risk for major psychiatric disorders: a delineation of four potential pathways to illness. | Kendler KS et al. | β | 2018 | β |
| The many roads to psychosis: recent advances in understanding risk and mechanisms. | Bearden CE et al. | β | 2018 | β |
| The Role of the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Neuropsychiatric Disorders. | Amorim IS et al. | β | 2018 | β |
| Unique Molecular Regulation of Higher-Order Prefrontal Cortical Circuits: Insights into the Neurobiology of Schizophrenia. | Datta D et al. | β | 2018 | β |
| Validation of a microRNA target site polymorphism in H3F3B that is potentially associated with a broad schizophrenia phenotype. | Manley W et al. | β | 2018 | β |
| Weighted Burden Analysis of Exome-Sequenced Case-Control Sample Implicates Synaptic Genes in Schizophrenia Aetiology. | Curtis D et al. | β | 2018 | β |
| Adolescent stress leads to glutamatergic disturbance through dopaminergic abnormalities in the prefrontal cortex of genetically vulnerable mice. | Matsumoto Y et al. | β | 2017 | β |
| A genomic lifespan program that reorganises the young adult brain is targeted in schizophrenia. | Skene NG et al. | β | 2017 | β |
| Altered Expression of ARP2/3 Complex Signaling Pathway Genes in Prefrontal Layer 3 Pyramidal Cells in Schizophrenia. | Datta D et al. | β | 2017 | β |
| AMPA receptors control fear extinction through an Arc-dependent mechanism. | Trent S et al. | β | 2017 | β |
| A Novel Kleefstra Syndrome-associated Variant That Affects the Conserved TPL<i>X</i> Motif within the Ankyrin Repeat of EHMT1 Leads to Abnormal Protein Folding. | Blackburn PR et al. | β | 2017 | β |
| Application of induced pluripotent stem cells to understand neurobiological basis of bipolar disorder and schizophrenia. | Liu YN et al. | β | 2017 | β |
| Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence. | FernΓ‘ndez E et al. | β | 2017 | β |
| A replication study of schizophrenia-related rare copy number variations in a Han Southern Chinese population. | Yuan J et al. | β | 2017 | β |
| Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia. | Kassan A et al. | β | 2017 | β |
| Challenges and opportunities for the development of new antipsychotic drugs. | Forray C et al. | β | 2017 | β |
| Classics in Chemical Neuroscience: Ketamine. | Tyler MW et al. | β | 2017 | β |
| Cognitive Performance Among Carriers of Pathogenic Copy Number Variants: Analysis of 152,000 UK Biobank Subjects. | Kendall KM et al. | β | 2017 | β |
| Common developmental genome deprogramming in schizophrenia - Role of Integrative Nuclear FGFR1 Signaling (INFS). | Narla ST et al. | β | 2017 | β |
| Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. | Marshall CR et al. | β | 2017 | β |
| Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future. | Alural B et al. | β | 2017 | β |
| Dopamine is Required for Activity-Dependent Amplification of Arc mRNA in Developing Postnatal Frontal Cortex. | Ye Y et al. | β | 2017 | β |
| Evolution of complexity in the zebrafish synapse proteome. | BayΓ©s Γ et al. | β | 2017 | β |
| Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity. | Kim MJ et al. | β | 2017 | β |
| Genetic and molecular risk factors within the newly identified primate-specific exon of the SAP97/DLG1 gene in the 3q29 schizophrenia-associated locus. | Uezato A et al. | β | 2017 | β |
| Genetic association analysis of microRNA137 and its target complex 1 with schizophrenia in Han Chinese. | Lu W et al. | β | 2017 | β |
| Genetic contribution to two factors of neuroticism is associated with affluence, better health, and longer life | Hill WD et al. | β | 2017 | β |
| Genetic interaction of DISC1 and Neurexin in the development of fruit fly glutamatergic synapses. | Pandey H et al. | β | 2017 | β |
| Genetics of schizophrenia: A consensus paper of the WFSBP Task Force on Genetics. | Giegling I et al. | β | 2017 | β |
| Genetics of Schizophrenia: Ready to Translate? | Foley C et al. | β | 2017 | β |
| Genome-wide association analysis identifies common variants influencing infant brain volumes. | Xia K et al. | β | 2017 | β |
| Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism. | Naaijen J et al. | β | 2017 | β |
| High-resolution copy number variation analysis of schizophrenia in Japan. | Kushima I et al. | β | 2017 | β |
| Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning. | Clifton NE et al. | β | 2017 | β |
| <i>Drosophila</i> Model for the Analysis of Genesis of LIM-kinase 1-Dependent Williams-Beuren Syndrome Cognitive Phenotypes: INDELs, Transposable Elements of the Tc1/<i>Mariner</i> Superfamily and MicroRNAs. | Savvateeva-Popova EV et al. | β | 2017 | β |
| Impact of IQ on the diagnostic yield of chromosomal microarray in a community sample of adults with schizophrenia. | Lowther C et al. | β | 2017 | β |
| Implication of the APP Gene in Intellectual Abilities. | Myrum C et al. | β | 2017 | β |
| Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders. | Nguyen HT et al. | β | 2017 | β |
| Magnetoencephalography as a Tool in Psychiatric Research: Current Status and Perspective. | Uhlhaas PJ et al. | β | 2017 | β |
| Mapping the Consequences of Impaired Synaptic Plasticity in Schizophrenia through Development: An Integrative Model for Diverse Clinical Features. | Forsyth JK et al. | β | 2017 | β |
| Modulating Neuroinflammation to Treat Neuropsychiatric Disorders. | Radtke FA et al. | β | 2017 | β |
| Molecular mechanisms underlying noncoding risk variations in psychiatric genetic studies. | Xiao X et al. | β | 2017 | β |
| Novel promoters and coding first exons in DLG2 linked to developmental disorders and intellectual disability. | Reggiani C et al. | β | 2017 | β |
| Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development. | Chen X et al. | β | 2017 | β |
| Postsynaptic density protein transcripts are differentially modulated by minocycline alone or in add-on to haloperidol: Implications for treatment resistant schizophrenia. | Buonaguro EF et al. | β | 2017 | β |
| Post-zygotic genomic changes in glutamate and dopamine pathway genes may explain discordance of monozygotic twins for schizophrenia. | Castellani CA et al. | β | 2017 | β |
| Potential synergistic action of 19 schizophrenia risk genes in the thalamus. | Richard EA et al. | β | 2017 | β |
| Potential Value of Genomic Copy Number Variations in Schizophrenia. | Zhuo C et al. | β | 2017 | β |
| Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome. | Huang AY et al. | β | 2017 | β |
| Rare damaging variants in DNA repair and cell cycle pathways are associated with hippocampal and cognitive dysfunction: a combined genetic imaging study in first-episode treatment-naive patients with schizophrenia. | Yang Z et al. | β | 2017 | β |
| Rare Genome-Wide Copy Number Variation and Expression of Schizophrenia in 22q11.2 Deletion Syndrome. | Bassett AS et al. | β | 2017 | β |
| Reframing autism as a behavioral syndrome and not a specific mental disorder: Implications of genetic and phenotypic heterogeneity. | Tordjman S et al. | β | 2017 | β |
| Schizophrenia and the neurodevelopmental continuum:evidence from genomics. | Owen MJ et al. | β | 2017 | β |
| Schizophrenia: Basic and Clinical. | Coyle JT | β | 2017 | β |
| Schizophrenia copy number variants and associative learning. | Clifton NE et al. | β | 2017 | β |
| Schizophrenia genetics in the genome-wide era: a review of Japanese studies. | Kanazawa T et al. | β | 2017 | β |
| [Search for risk genes in schizophrenia]. | Rujescu D | β | 2017 | β |
| Shifting the focus toward rare variants in schizophrenia to close the gap from genotype to phenotype. | Bustamante ML et al. | β | 2017 | β |
| Sleep Disturbance as a Precursor of Severe Regression in Kleefstra Syndrome Suggests a Need for Firm and Rapid Pharmacological Treatment. | Vermeulen K et al. | β | 2017 | β |
| Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. | Li J et al. | β | 2017 | β |
| Synapse pathology and translational applications for schizophrenia. | Hayashi-Takagi A | β | 2017 | β |
| Synaptic activity: An emerging player in schizophrenia. | Sarkar A et al. | β | 2017 | β |
| Thalamo-cortical communication, glutamatergic neurotransmission and neural oscillations: A unique window into the origins of ScZ? | Pratt J et al. | β | 2017 | β |
| The contribution of rare variants to risk of schizophrenia in individuals with and without intellectual disability. | Singh T et al. | β | 2017 | β |
| The DLGAP family: neuronal expression, function and role in brain disorders. | Rasmussen AH et al. | β | 2017 | β |
| Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies. | O'Tuathaigh CMP et al. | β | 2017 | β |
| Ultra-rare genetic variation in common epilepsies: a case-control sequencing study. | Epi4K consortium et al. | β | 2017 | β |
| Unraveling the genetic architecture of copy number variants associated with schizophrenia and other neuropsychiatric disorders. | Rutkowski TP et al. | β | 2017 | β |
| Unraveling the Neurobiology of Sleep and Sleep Disorders Using Drosophila. | Chakravarti L et al. | β | 2017 | β |
| Using hiPSCs to model neuropsychiatric copy number variations (CNVs) has potential to reveal underlying disease mechanisms. | Flaherty EK et al. | β | 2017 | β |
| Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia. | Tang J et al. | β | 2017 | β |
| A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function. | Zeng M et al. | β | 2016 | β |
| A Mutation in NPAS3 That Segregates with Schizophrenia in a Small Family Leads to Protein Aggregation. | Nucifora LG et al. | β | 2016 | β |
| An Association Study Between Genetic Polymorphisms in Functional Regions of Five Genes and the Risk of Schizophrenia. | Yan P et al. | β | 2016 | β |
| Animal models of gene-environment interaction in schizophrenia: A dimensional perspective. | Ayhan Y et al. | β | 2016 | β |
| An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia. | Balu DT et al. | β | 2016 | β |
| A novel 3q29 deletion associated with autism, intellectual disability, psychiatric disorders, and obesity. | Biamino E et al. | β | 2016 | β |
| A quantitative review of the postmortem evidence for decreased cortical N-methyl-D-aspartate receptor expression levels in schizophrenia: How can we link molecular abnormalities to mismatch negativity deficits? | Catts VS et al. | β | 2016 | β |
| Autism Spectrum Disorder, Developmental and Psychiatric Features in 16p11.2 Duplication. | Green Snyder L et al. | β | 2016 | β |
| Autoantibodies to central nervous system neuronal surface antigens: psychiatric symptoms and psychopharmacological implications. | Pollak TA et al. | β | 2016 | β |
| Common alleles contribute to schizophrenia in CNV carriers. | Tansey KE et al. | β | 2016 | β |
| Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes. | Pers TH et al. | β | 2016 | β |
| Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia part II: Cognition, neuroimaging and genetics. | Schmitt A et al. | β | 2016 | β |
| Copy number variation in bipolar disorder. | Green EK et al. | β | 2016 | β |
| Cyfip1 Regulates Presynaptic Activity during Development. | Hsiao K et al. | β | 2016 | β |
| Differential expression of transcriptional regulatory units in the prefrontal cortex of patients with bipolar disorder: potential role of early growth response gene 3. | Pfaffenseller B et al. | β | 2016 | β |
| Electrophysiological Endophenotypes for Schizophrenia. | Owens EM et al. | β | 2016 | β |
| Epigenetic Basis of Mental Illness. | Nestler EJ et al. | β | 2016 | β |
| Euchromatin histone methyltransferase 1 regulates cortical neuronal network development. | Martens MB et al. | β | 2016 | β |
| Exome arrays capture polygenic rare variant contributions to schizophrenia. | Richards AL et al. | β | 2016 | β |
| Exome Sequence Data From Multigenerational Families Implicate AMPA Receptor Trafficking in Neurocognitive Impairment and Schizophrenia Risk. | Kos MZ et al. | β | 2016 | β |
| Exome Sequencing of Familial Bipolar Disorder. | Goes FS et al. | β | 2016 | β |
| Gene expression elucidates functional impact of polygenic risk for schizophrenia. | Fromer M et al. | β | 2016 | β |
| Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study. | Greenwood TA et al. | β | 2016 | β |
| Genetic Feedback Regulation of Frontal Cortical Neuronal Ensembles Through Activity-Dependent Arc Expression and Dopaminergic Input. | Mastwal S et al. | β | 2016 | β |
| Genetics of Bipolar Disorder: Recent Update and Future Directions. | Goes FS | β | 2016 | β |
| [Genomic instability in the brain: chromosomal mosaicism in schizophrenia]. | Yurov YB et al. | β | 2016 | β |
| Germline De Novo Mutations in GNB1 Cause Severe Neurodevelopmental Disability, Hypotonia, and Seizures. | Petrovski S et al. | β | 2016 | β |
| Histone Methylation by the Kleefstra Syndrome Protein EHMT1 Mediates Homeostatic Synaptic Scaling. | Benevento M et al. | β | 2016 | β |
| Histone turnover and chromatin accessibility: Critical mediators of neurological development, plasticity, and disease. | Wenderski W et al. | β | 2016 | β |
| History of the Concept of Disconnectivity in Schizophrenia. | Coyle JT et al. | β | 2016 | β |
| Identification of a rare variant in CHD8 that contributes to schizophrenia and autism spectrum disorder susceptibility. | Kimura H et al. | β | 2016 | β |
| Identification of rare variants in KCTD13 at the schizophrenia risk locus 16p11.2. | Degenhardt F et al. | β | 2016 | β |
| Identification of RELN variation p.Thr3192Ser in a Chinese family with schizophrenia. | Zhou Z et al. | β | 2016 | β |
| Increased burden of ultra-rare protein-altering variants among 4,877 individuals with schizophrenia. | Genovese G et al. | β | 2016 | β |
| Inhibitors of enzymes catalyzing modifications to histone lysine residues: structure, function and activity. | Lillico R et al. | β | 2016 | β |
| Integrated Post-GWAS Analysis Sheds New Light on the Disease Mechanisms of Schizophrenia. | Lin JR et al. | β | 2016 | β |
| L1-associated genomic regions are deleted in somatic cells of the healthy human brain. | Erwin JA et al. | β | 2016 | β |
| Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. | Li J et al. | β | 2016 | β |
| Microglia Transcriptome Changes in a Model of Depressive Behavior after Immune Challenge. | Gonzalez-Pena D et al. | β | 2016 | β |
| Molecular Risk Factors for Schizophrenia. | Modai S et al. | β | 2016 | β |
| Monkey Prefrontal Neurons Reflect Logical Operations for Cognitive Control in a Variant of the AX Continuous Performance Task (AX-CPT). | Blackman RK et al. | β | 2016 | β |
| Multiscale Modeling of Gene-Behavior Associations in an Artificial Neural Network Model of Cognitive Development. | Thomas MS et al. | β | 2016 | β |
| Mutation screening of SCN2A in schizophrenia and identification of a novel loss-of-function mutation. | Carroll LS et al. | β | 2016 | β |
| NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. | Frank RA et al. | β | 2016 | β |
| Patterns of genic intolerance of rare copy number variation in 59,898 human exomes. | Ruderfer DM et al. | β | 2016 | β |
| Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M<sub>1</sub> PAM VU6004256. | Grannan MD et al. | β | 2016 | β |
| Protein Interaction Networks Link Schizophrenia Risk Loci to Synaptic Function. | Schwarz E et al. | β | 2016 | β |
| Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder. | FΓΆcking M et al. | β | 2016 | β |
| Proteomics of the Synapse--A Quantitative Approach to Neuronal Plasticity. | Dieterich DC et al. | β | 2016 | β |
| PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits. | Broadhead MJ et al. | β | 2016 | β |
| Psychiatric gene discoveries shape evidence on ADHD's biology. | Thapar A et al. | β | 2016 | β |
| Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders. | Singh T et al. | β | 2016 | β |
| Rare mutations and hypermethylation of the ARC gene associated with schizophrenia. | Chuang YA et al. | β | 2016 | β |
| Recurrent copy number variations as risk factors for neurodevelopmental disorders: critical overview and analysis of clinical implications. | Torres F et al. | β | 2016 | β |
| Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A "central hub" in schizophrenia pathophysiology? | Steullet P et al. | β | 2016 | β |
| Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders. | Xing J et al. | β | 2016 | β |
| Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub. | Blizinsky KD et al. | β | 2016 | β |
| Schizophrenia. | Owen MJ et al. | β | 2016 | β |
| Schizophrenia risk from complex variation of complement component 4. | Sekar A et al. | β | 2016 | β |
| Specialized roles of neurofilament proteins in synapses: Relevance to neuropsychiatric disorders. | Yuan A et al. | β | 2016 | β |
| Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014. | Aas M et al. | β | 2016 | β |
| Switching antipsychotics: Imaging the differential effect on the topography of postsynaptic density transcripts in antipsychotic-naΓ―ve vs. antipsychotic-exposed rats. | de Bartolomeis A et al. | β | 2016 | β |
| Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease. | Johnson MR et al. | β | 2016 | β |
| Targeted next generation sequencing of a panel of autism-related genes identifies an EHMT1 mutation in a Kleefstra syndrome patient with autism and normal intellectual performance. | Bock I et al. | β | 2016 | β |
| The implications of the shared genetics of psychiatric disorders. | O'Donovan MC et al. | β | 2016 | β |
| The molecular evolution of the vertebrate behavioural repertoire. | Grant SG | β | 2016 | β |
| The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment. | Balu DT | β | 2016 | β |
| Treatment-resistant schizophrenia: current insights on the pharmacogenomics of antipsychotics. | Lally J et al. | β | 2016 | β |
| Using model systems to understand errant plasticity mechanisms in psychiatric disorders. | Averbeck BB et al. | β | 2016 | β |
| Voltage-gated calcium channels - from basic mechanisms to disease. | Striessnig J | β | 2016 | β |
| What Next in Schizophrenia Genetics for the Psychiatric Genomics Consortium? | Corvin A et al. | β | 2016 | β |
| Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia. | MacDonald ML et al. | β | 2015 | β |
| Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia. | Rees E et al. | β | 2015 | β |
| A New Method for Detecting Associations with Rare Copy-Number Variants. | Tzeng JY et al. | β | 2015 | β |
| A novel maternally inherited 8q24.3 and a rare paternally inherited 14q23.3 CNVs in a family with neurodevelopmental disorders. | Hu J et al. | β | 2015 | β |
| Assessment of copy number variations in the brain genome of schizophrenia patients. | Sakai M et al. | β | 2015 | β |
| Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk. | Huentelman MJ et al. | β | 2015 | β |
| Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene. | Nithianantharajah J et al. | β | 2015 | β |
| Clinically relevant copy number variations detected in cerebral palsy. | Oskoui M et al. | β | 2015 | β |
| CNVs in neuropsychiatric disorders. | Kirov G | β | 2015 | β |
| Common genetic variants influence human subcortical brain structures. | Hibar DP et al. | β | 2015 | β |
| Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders. | Gao R et al. | β | 2015 | β |
| Common variants in the ARC gene are not associated withΒ cognitive abilities. | Myrum C et al. | β | 2015 | β |
| Copy number variable microRNAs in schizophrenia and their neurodevelopmental gene targets. | Warnica W et al. | β | 2015 | β |
| Copy number variation in schizophrenia. | Gulsuner S et al. | β | 2015 | β |
| Decoding Advances in Psychiatric Genetics: A Focus on Neural Circuits in Rodent Models. | Heckenast JR et al. | β | 2015 | β |
| Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring. | Sharma R et al. | β | 2015 | β |
| Evidence of Mitochondrial Dysfunction within the Complex Genetic Etiology of Schizophrenia. | Hjelm BE et al. | β | 2015 | β |
| Exome sequence read depth methods for identifying copy number changes. | Kadalayil L et al. | β | 2015 | β |
| Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case-control sample of schizophrenia. | Ingason A et al. | β | 2015 | β |
| From de novo mutations to personalized therapeutic interventions in autism. | Brandler WM et al. | β | 2015 | β |
| Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation. | Neale BM et al. | β | 2015 | β |
| Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity. | Hall J et al. | β | 2015 | β |
| Genetic studies of schizophrenia: an update. | Chen J et al. | β | 2015 | β |
| Glutamate synapses in human cognitive disorders. | Volk L et al. | β | 2015 | β |
| Haplotype phasing and inheritance of copy number variants in nuclear families. | Palta P et al. | β | 2015 | β |
| Identification and functional characterization of rare SHANK2 variants in schizophrenia. | Peykov S et al. | β | 2015 | β |
| Increased visual gamma power in schizoaffective bipolar disorder. | Brealy JA et al. | β | 2015 | β |
| Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice. | Foote M et al. | β | 2015 | β |
| Ketamine Dysregulates the Amplitude and Connectivity of High-Frequency Oscillations in Cortical-Subcortical Networks in Humans: Evidence From Resting-State Magnetoencephalography-Recordings. | Rivolta D et al. | β | 2015 | β |
| Magnetic resonance spectroscopy and tissue protein concentrations together suggest lower glutamate signaling in dentate gyrus in schizophrenia. | Stan AD et al. | β | 2015 | β |
| MicroRNAs in Schizophrenia: Implications for Synaptic Plasticity and Dopamine-Glutamate Interaction at the Postsynaptic Density. New Avenues for Antipsychotic Treatment Under a Theranostic Perspective. | de Bartolomeis A et al. | β | 2015 | β |
| Modeling combined schizophrenia-related behavioral and metabolic phenotypes in rodents. | Sarnyai Z et al. | β | 2015 | β |
| Molecular evidence for decreased synaptic efficacy in the postmortem olfactory bulb of individuals with schizophrenia. | Egbujo CN et al. | β | 2015 | β |
| Neural and behavioral epigenetics; what it is, and what is hype. | Isles AR | β | 2015 | β |
| Neural oscillations as a translational tool in schizophrenia research: rationale, paradigms and challenges. | Phillips KG et al. | β | 2015 | β |
| [Neurobiology of schizophrenia: new findings from the structure to the molecules]. | Schmitt A et al. | β | 2015 | β |
| New discoveries in schizophrenia genetics reveal neurobiological pathways: A review of recent findings. | Kotlar AV et al. | β | 2015 | β |
| No Evidence for Enrichment in Schizophrenia for Common Allelic Associations at Imprinted Loci. | Escott-Price V et al. | β | 2015 | β |
| Novel Findings from CNVs Implicate Inhibitory and Excitatory Signaling Complexes in Schizophrenia. | Pocklington AJ et al. | β | 2015 | β |
| Novel genetic advances in schizophrenia: an interview with Michael O'Donovan. | O'Donovan M | β | 2015 | β |
| Performance of case-control rare copy number variation annotation in classification of autism. | Engchuan W et al. | β | 2015 | β |
| Postsynaptic density levels of the NMDA receptor NR1 subunit and PSD-95 protein in prefrontal cortex from people with schizophrenia. | Catts VS et al. | β | 2015 | β |
| Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia. | FΓΆcking M et al. | β | 2015 | β |
| Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. | Network and Pathway Analysis Subgroup of Psychiatric Genomics Consortium | β | 2015 | β |
| Psychopathology and cognitive performance in individuals with membrane-associated guanylate kinase mutations: a functional network phenotyping study. | Baker K et al. | β | 2015 | β |
| Recent advances in the genetics of autism spectrum disorder. | De Rubeis S et al. | β | 2015 | β |
| Recent genetic findings in schizophrenia and their therapeutic relevance. | Harrison PJ | β | 2015 | β |
| Schizophrenia genetics: building the foundations of the future. | Tansey KE et al. | β | 2015 | β |
| Schizophrenia genetics: emerging themes for a complex disorder. | Kavanagh DH et al. | β | 2015 | β |
| Specific Roles of NMDA Receptor Subunits in Mental Disorders. | Yamamoto H et al. | β | 2015 | β |
| Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine. | Kim IH et al. | β | 2015 | β |
| Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia. | Banerjee A et al. | β | 2015 | β |
| S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model. | Zhang N et al. | β | 2015 | β |
| Subchronic pharmacological and chronic genetic NMDA receptor hypofunction differentially regulate the Akt signaling pathway and Arc expression in juvenile and adult mice. | Takagi S et al. | β | 2015 | β |
| The human clinical phenotypes of altered CHRNA7 copy number. | Gillentine MA et al. | β | 2015 | β |
| The impact of human copy number variation on gene expression. | Gamazon ER et al. | β | 2015 | β |
| The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond. | Balu DT et al. | β | 2015 | β |
| The proteome of schizophrenia. | Nascimento JM et al. | β | 2015 | β |
| Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder. | Zhao Z et al. | β | 2015 | β |
| What have we learned from the Psychiatric Genomics Consortium. | O'Donovan MC | β | 2015 | β |
| Whole-Genome Sequencing Suggests Schizophrenia Risk Mechanisms in Humans with 22q11.2 Deletion Syndrome. | Merico D et al. | β | 2015 | β |
| Age-related decreased inhibitory vs. excitatory gene expression in the adult autistic brain. | van de Lagemaat LN et al. | β | 2014 | β |
| A meta-analysis of gene expression quantitative trait loci in brain. | Kim Y et al. | β | 2014 | β |
| Analysis of copy number variations at 15 schizophrenia-associated loci. | Rees E et al. | β | 2014 | β |
| Antibodies to the N-methyl-D-aspartate receptor and other synaptic proteins in psychosis. | Deakin J et al. | β | 2014 | β |
| A polygenic burden of rare disruptive mutations in schizophrenia. | Purcell SM et al. | β | 2014 | β |
| Biological insights from 108 schizophrenia-associated genetic loci. | Schizophrenia Working Group of the Psychiatric Genomics Consortium | β | 2014 | β |
| Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. | Martin J et al. | β | 2014 | β |
| Chromosomal microarray analysis-a routine clinical genetic test for patients with schizophrenia. | Baker K et al. | β | 2014 | β |
| Chronic D-serine reverses arc expression and partially rescues dendritic abnormalities in a mouse model of NMDA receptor hypofunction. | Balu DT et al. | β | 2014 | β |
| Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia. | Martin DA et al. | β | 2014 | β |
| CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1. | Rees E et al. | β | 2014 | β |
| Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. | Pinto D et al. | β | 2014 | β |
| Copy number variants and therapeutic response to antidepressant medication in major depressive disorder. | Tansey KE et al. | β | 2014 | β |
| Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. | McGrath LM et al. | β | 2014 | β |
| Copy number variation in schizophrenia in Sweden. | Szatkiewicz JP et al. | β | 2014 | β |
| De novo CNVs in bipolar affective disorder and schizophrenia. | Georgieva L et al. | β | 2014 | β |
| De novo mutations in schizophrenia implicate synaptic networks. | Fromer M et al. | β | 2014 | β |
| DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan. | Porteous DJ et al. | β | 2014 | β |
| Epigenetic mechanisms in schizophrenia. | Akbarian S | β | 2014 | β |
| Evidence for the role of EPHX2 gene variants in anorexia nervosa. | Scott-Van Zeeland AA et al. | β | 2014 | β |
| Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders. | Kenny EM et al. | β | 2014 | β |
| Exome sequencing in 53 sporadic cases of schizophrenia identifies 18 putative candidate genes. | Guipponi M et al. | β | 2014 | β |
| Explaining additional genetic variation in complex traits. | Robinson MR et al. | β | 2014 | β |
| Genetics of schizophrenia. | Escudero I et al. | β | 2014 | β |
| Genetics: Unravelling complexity. | Wright J | β | 2014 | β |
| Genome-wide copy number variation study reveals KCNIP1 as a modulator of insulin secretion. | Lee HS et al. | β | 2014 | β |
| Genome-wide methylation profiling of schizophrenia. | Rukova B et al. | β | 2014 | β |
| Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice. | Doherty JL et al. | β | 2014 | β |
| High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons. | Nieland TJ et al. | β | 2014 | β |
| Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins. | Hill WD et al. | β | 2014 | β |
| Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexes. | BayΓ©s Γ et al. | β | 2014 | β |
| Integrated systems analysis reveals a molecular network underlying autism spectrum disorders. | Li J et al. | β | 2014 | β |
| Large-scale genomics unveils the genetic architecture of psychiatric disorders. | Gratten J et al. | β | 2014 | β |
| Loss-of-function variants in schizophrenia risk and SETD1A as a candidate susceptibility gene. | Takata A et al. | β | 2014 | β |
| MicroRNA Dysregulation, Gene Networks, and Risk for Schizophrenia in 22q11.2 Deletion Syndrome. | Merico D et al. | β | 2014 | β |
| Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. | Mei L et al. | β | 2014 | β |
| Neuroinformatic analyses of common and distinct genetic components associated with major neuropsychiatric disorders. | Lotan A et al. | β | 2014 | β |
| Neuropsychological phenotype of a patient with a de novo 970 kb interstitial deletion in the distal 16p11.2 region. | Egger JI et al. | β | 2014 | β |
| New approaches to psychiatric diagnostic classification. | Owen MJ | β | 2014 | β |
| Novel treatment strategies for schizophrenia from improved understanding of genetic risk. | Morris BJ et al. | β | 2014 | β |
| Reciprocal duplication of the Williams-Beuren syndrome deletion on chromosome 7q11.23 is associated with schizophrenia. | Mulle JG et al. | β | 2014 | β |
| Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility. | Lang B et al. | β | 2014 | β |
| Revitalizing psychiatric therapeutics. | Hyman SE | β | 2014 | β |
| Risk genes for schizophrenia: translational opportunities for drug discovery. | Winchester CL et al. | β | 2014 | β |
| Role of the DLGAP2 gene encoding the SAP90/PSD-95-associated protein 2 in schizophrenia. | Li JM et al. | β | 2014 | β |
| Scan statistic-based analysis of exome sequencing data identifies FAN1 at 15q13.3 as a susceptibility gene for schizophrenia and autism. | Ionita-Laza I et al. | β | 2014 | β |
| Sequence analysis of 17 NRXN1 deletions. | Enggaard Hoeffding LK et al. | β | 2014 | β |
| Synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia. | Crabtree GW et al. | β | 2014 | β |
| Systematic prioritization and integrative analysis of copy number variations in schizophrenia reveal key schizophrenia susceptibility genes. | Luo X et al. | β | 2014 | β |
| The 4th Schizophrenia International Research Society Conference, 5-9 April 2014, Florence, Italy: a summary of topics and trends. | Abayomi O et al. | β | 2014 | β |
| The adenosine neuromodulation system in schizophrenia. | Rial D et al. | β | 2014 | β |
| The epigenome and postnatal environmental influences in psychotic disorders. | Pishva E et al. | β | 2014 | β |
| The genetics of microdeletion and microduplication syndromes: an update. | Watson CT et al. | β | 2014 | β |
| The one and the many: effects of the cell adhesion molecule pathway on neuropsychological function in psychosis. | Hargreaves A et al. | β | 2014 | β |
| The phenotypic manifestations of rare CNVs in schizophrenia. | Merikangas AK et al. | β | 2014 | β |
| The synapse in schizophrenia. | Pocklington AJ et al. | β | 2014 | β |
| Transcriptional targets of the schizophrenia risk gene MIR137. | Collins AL et al. | β | 2014 | β |
| Unlocking the treasure trove: from genes to schizophrenia biology. | McCarthy SE et al. | β | 2014 | β |
| Using XHMM Software to Detect Copy Number Variation in Whole-Exome Sequencing Data. | Fromer M et al. | β | 2014 | β |
| What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit. | Barkus C et al. | β | 2014 | β |
| 22q11 deletion syndrome: a review of the neuropsychiatric features and their neurobiological basis. | Squarcione C et al. | β | 2013 | β |
| 3q29 microdeletion syndrome: Cognitive and behavioral phenotype in four patients. | CittΓ S et al. | β | 2013 | β |
| A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk. | Chapman J et al. | β | 2013 | β |
| A genome wide survey supports the involvement of large copy number variants in schizophrenia with and without intellectual disability. | Derks EM et al. | β | 2013 | β |
| A hierarchical coherent-gene-group model for brain development. | Tsigelny IF et al. | β | 2013 | β |
| A new paradigm emerges from the study of de novo mutations in the context of neurodevelopmental disease. | Ku CS et al. | β | 2013 | β |
| Biological psychiatry: time for new paradigms. | Linden D | β | 2013 | β |
| Clinical phenotypes of psychosis in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP). | Tamminga CA et al. | β | 2013 | β |
| Cognitive components in mice and humans: combining genetics and touchscreens for medical translation. | Nithianantharajah J et al. | β | 2013 | β |
| Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. | Takao K et al. | β | 2013 | β |
| De novo 15q13.3 microdeletion with cryptogenic West syndrome. | Lacaze E et al. | β | 2013 | β |
| Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders. | Penzes P et al. | β | 2013 | β |
| Distribution of disease-associated copy number variants across distinct disorders of cognitive development. | Pescosolido MF et al. | β | 2013 | β |
| Does epilepsy in multiplex autism pedigrees define a different subgroup in terms of clinical characteristics and genetic risk? | Amiet C et al. | β | 2013 | β |
| Epigenetic determinants of healthy and diseased brain aging and cognition. | Akbarian S et al. | β | 2013 | β |
| Genetics of psychiatric disorders in the GWAS era: an update on schizophrenia. | Schwab SG et al. | β | 2013 | β |
| Genome-wide association study of obsessive-compulsive disorder. | Stewart SE et al. | β | 2013 | β |
| Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. | Hamshere ML et al. | β | 2013 | β |
| High-frequency neural oscillations and visual processing deficits in schizophrenia. | Tan H-RM et al. | β | 2013 | β |
| High-frequency oscillations and the neurobiology of schizophrenia. | Uhlhaas PJ et al. | β | 2013 | β |
| Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome. | Balemans MC et al. | β | 2013 | β |
| Identification of rare copy number variants in high burden schizophrenia families. | Van Den Bossche MJ et al. | β | 2013 | β |
| Identification of rare recurrent copy number variants in high-risk autism families and their prevalence in a large ASD population. | Matsunami N et al. | β | 2013 | β |
| Identifying essential cell types and circuits in autism spectrum disorders. | Maloney SE et al. | β | 2013 | β |
| Implication of a rare deletion at distal 16p11.2 in schizophrenia. | Guha S et al. | β | 2013 | β |
| Infantile spasms are associated with abnormal copy number variations. | Tiwari VN et al. | β | 2013 | β |
| mGluR5 ablation in cortical glutamatergic neurons increases novelty-induced locomotion. | Jew CP et al. | β | 2013 | β |
| Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction. | Balu DT et al. | β | 2013 | β |
| Next-generation sequencing in schizophrenia and other neuropsychiatric disorders. | Schreiber M et al. | β | 2013 | β |
| No association between general cognitive ability and rare copy number variation. | McRae AF et al. | β | 2013 | β |
| Pathogenic rare copy number variants in community-based schizophrenia suggest a potential role for clinical microarrays. | Costain G et al. | β | 2013 | β |
| Phenotypic impact of genomic structural variation: insights from and for human disease. | Weischenfeldt J et al. | β | 2013 | β |
| Prefrontal cortical dysfunction after overexpression of histone deacetylase 1. | Jakovcevski M et al. | β | 2013 | β |
| Prenatal immune activation interacts with stress and corticosterone exposure later in life to modulate N-methyl-D-aspartate receptor synaptic function and plasticity. | Burt MA et al. | β | 2013 | β |
| Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiology. | McCarroll SA et al. | β | 2013 | β |
| Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophrenia and seizures. | Lionel AC et al. | β | 2013 | β |
| Recent advances in quantitative neuroproteomics. | Craft GE et al. | β | 2013 | β |
| Scaffolding proteins of the post-synaptic density contribute to synaptic plasticity by regulating receptor localization and distribution: relevance for neuropsychiatric diseases. | Iasevoli F et al. | β | 2013 | β |
| "Selfish spermatogonial selection": a novel mechanism for the association between advanced paternal age and neurodevelopmental disorders. | Goriely A et al. | β | 2013 | β |
| Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network. | Gulsuner S et al. | β | 2013 | β |
| Synaptic scaffold evolution generated components of vertebrate cognitive complexity. | Nithianantharajah J et al. | β | 2013 | β |
| The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variants. | Mowry BJ et al. | β | 2013 | β |
| The genomics of schizophrenia: update and implications. | Giusti-RodrΓguez P et al. | β | 2013 | β |
| Absence of de novo point mutations in exons of GRIN2B in a large schizophrenia trio sample. | Williams HJ et al. | β | 2012 | β |
| Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translational gap. | Pratt J et al. | β | 2012 | β |
| A genetic model for neurodevelopmental disease. | Coe BP et al. | β | 2012 | β |
| A new era in the discovery of de novo mutations underlying human genetic disease. | Ku CS et al. | β | 2012 | β |
| A simple cell-based assay reveals that diverse neuropsychiatric risk genes converge on primary cilia. | Marley A et al. | β | 2012 | β |
| Clinical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era. | Costain G et al. | β | 2012 | β |
| CNVs: harbingers of a rare variant revolution in psychiatric genetics. | Malhotra D et al. | β | 2012 | β |
| Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. | Ayalew M et al. | β | 2012 | β |
| Creativity and mental disorder. | Kirov G et al. | β | 2012 | β |
| De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia. | Xu B et al. | β | 2012 | β |
| De novo mutation in schizophrenia. | Rees E et al. | β | 2012 | β |
| Discovery and statistical genotyping of copy-number variation from whole-exome sequencing depth. | Fromer M et al. | β | 2012 | β |
| Diverse types of genetic variation converge on functional gene networks involved in schizophrenia. | Gilman SR et al. | β | 2012 | β |
| DNA methylation in schizophrenia: progress and challenges of epigenetic studies. | Nishioka M et al. | β | 2012 | β |
| Epigenetic mechanisms in neurological disease. | Jakovcevski M et al. | β | 2012 | β |
| Evolution of synapse complexity and diversity. | Emes RD et al. | β | 2012 | β |
| Genetic architecture in autism spectrum disorder. | Devlin B et al. | β | 2012 | β |
| Genetic architectures of psychiatric disorders: the emerging picture and its implications. | Sullivan PF et al. | β | 2012 | β |
| Genetics of schizophrenia from a clinicial perspective. | Kukshal P et al. | β | 2012 | β |
| Identification and characterization of three inherited genomic copy number variations associated with familial schizophrenia. | Liao HM et al. | β | 2012 | β |
| Identification of a CACNA2D4 deletion in late onset bipolar disorder patients and implications for the involvement of voltage-dependent calcium channels in psychiatric disorders. | Van Den Bossche MJ et al. | β | 2012 | β |
| Implications of genetic findings for understanding schizophrenia. | Owen MJ | β | 2012 | β |
| MAGI1 copy number variation in bipolar affective disorder and schizophrenia. | Karlsson R et al. | β | 2012 | β |
| NMDA receptor and schizophrenia: a brief history. | Coyle JT | β | 2012 | β |
| Rare copy number variants in neuropsychiatric disorders: Specific phenotype or not? | Van Den Bossche MJ et al. | β | 2012 | β |
| Rare variants in complex traits: novel identification strategies and the role of de novo mutations. | Jouan L et al. | β | 2012 | β |
| Revolution stalled. | Hyman SE | β | 2012 | β |
| Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries. | Talkowski ME et al. | β | 2012 | β |
| Synaptopathies: diseases of the synaptome. | Grant SG | β | 2012 | β |
| Systems biology, bioinformatics, and biomarkers in neuropsychiatry. | Alawieh A et al. | β | 2012 | β |
| Tardive dyskinesia is caused by maladaptive synaptic plasticity: a hypothesis. | Teo JT et al. | β | 2012 | β |
| The genetic variability and commonality of neurodevelopmental disease. | Coe BP et al. | β | 2012 | β |
| The rational use of animals in drug development: contribution of the innovative medicines initiative. | Magda G et al. | β | 2012 | β |
| TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function. | Coba MP et al. | β | 2012 | β |
| Zebrafish homologs of genes within 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes. | Blaker-Lee A et al. | β | 2012 | β |
| High frequencies of de novo CNVs in bipolar disorder and schizophrenia. | Malhotra D et al. | β | 2011 | β |