Degrees of alcohol intoxication in 117 hospitalized cases.
- Authors
- Adachi, J; Mizoi, Y; Fukunaga, T; Ogawa, Y; Ueno, Y; Imamichi, H
- Year
- 1991
- Journal
- Journal of studies on alcohol
- PMID
- 1943100
- DOI
- 10.15288/jsa.1991.52.448
The correlation among degrees of alcohol intoxication, facial flushing, blood alcohol concentration (BAC) and blood acetaldehyde level was studied in 117 male alcoholic patients who underwent various tests to assess alcohol influence. Blood samples were collected and alcohol and acetaldehyde levels were determined. BACs ranged from 29 to 577 mg/dl in all patients and from 200 to 299 mg/dl in 48 of them. Fifty-one patients could stand erect (mean BAC [+/- SD] = 189 +/- 80 mg/dl), while 48 showed apparently normal reaction to a walking and turning test (mean BAC = 192 +/- 78 mg/dl). Some of the cases having BACs over 300 mg/dl could still stand and walk while others with BACs under 100 mg/dl already showed psychomotor impairment. Facial flushing was recognized in 75% of the subjects. Acetaldehyde concentrations in 27 patients ranged from 24 to 147 micrograms/dl. Appearance of facial flushing was correlated with relatively high concentrations of blood acetaldehyde. Seven out of 10 healthy volunteers given 1.6 to 2.0 g/kg of alcohol as a control could do nothing but sleep after reaching peak BAC (mean = 232 +/- 21 mg/dl). These findings are taken to indicate a great difference in response to alcohol between alcoholics and healthy men. This study is the first to report the occurrence of facial flushing and raised blood acetaldehyde concentration among Japanese alcoholics.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. | 2014 | 25129674 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Ethanol Alters DNMT1/3a/3b Expression Profile, Promotes Persistent DNA Hypomethylation in Human Brain Endothelial Cells and Impairs Late Cortical Angiogenesis. | Siqueira M et al. | β | 2026 | β |
| MicroRNAs in fetal alcohol spectrum disorders: A systematic review of prenatal exposure and molecular targets. | Jahanabadi S et al. | β | 2026 | β |
| Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage. | GΓ³mez GI et al. | β | 2024 | β |
| Hemichannels contribute to mitochondrial Ca<sup>2+</sup> and morphology alterations evoked by ethanol in astrocytes. | Alvear TF et al. | β | 2024 | β |
| Nrf2 pathway activation promotes the expression of genes related to glutathione metabolism in alcohol-exposed astrocytes. | Li C et al. | β | 2024 | β |
| Ethanol exposure disrupted the formation of radial glial processes and impaired the generation and migration of outer radial glial cells in forebrain organoids derived from human embryonic stem cells. | LΓΌ L et al. | β | 2023 | β |
| Fasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis. | Zhao H et al. | β | 2023 | β |
| Prenatal alcohol alters inflammatory signatures in enteric portal tissues following adult-onset cerebrovascular ischemic stroke. | Pinson MR et al. | β | 2023 | β |
| Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure. | Chung DD et al. | β | 2023 | β |
| Vascular Contributions to the Neurobiological Effects of Prenatal Alcohol Exposure. | Momin SZ et al. | β | 2023 | β |
| Dose-related shifts in proteome and function of extracellular vesicles secreted by fetal neural stem cells following chronic alcohol exposure. | Chung DD et al. | β | 2022 | β |
| Gag-like proteins: Novel mediators of prenatal alcohol exposure in neural development. | Pinson MR et al. | β | 2022 | β |
| Up-regulation of microRNA-34a mediates ethanol-induced impairment of neural crest cell migration in vitro and in zebrafish embryos through modulating epithelial-mesenchymal transition by targeting Snail1. | Fan H et al. | β | 2022 | β |
| A novel Oct4/Pou5f1-like non-coding RNA controls neural maturation and mediates developmental effects of ethanol. | Salem NA et al. | β | 2021 | β |
| Characterization of Glycosaminoglycan Disaccharide Composition in Astrocyte Primary Cultures and the Cortex of Neonatal Rats. | Zhang X et al. | β | 2021 | β |
| Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period. | Pinson MR et al. | β | 2021 | β |
| Effects of ethanol-and choline-treated astrocytes on hippocampal neuron neurite outgrowth in vitro. | Goeke CM et al. | β | 2021 | β |
| Ethanol Disrupts Hormone-Induced Calcium Signaling in Liver. | Gaspers LD et al. | β | 2021 | β |
| Ethanol Gestational Exposure Impairs Vascular Development and Endothelial Potential to Control BBB-Associated Astrocyte Function in the Developing Cerebral Cortex. | Siqueira M et al. | β | 2021 | β |
| Ethanol modulation of hippocampal neuroinflammation, myelination, and neurodevelopment in a postnatal mouse model of fetal alcohol spectrum disorders. | Niedzwiedz-Massey VM et al. | β | 2021 | β |
| Prenatal alcohol-induced sex differences in immune, metabolic and neurobehavioral outcomes in adult rats. | Bake S et al. | β | 2021 | β |
| Chronic Ethanol Exposure Alters DNA Methylation in Neural Stem Cells: Role of Mouse Strain and Sex. | Amiri S et al. | β | 2020 | β |
| Chronic ethanol exposure induces neuroinflammation in H4 cells through TLR3 / NF-ΞΊB pathway and anxiety-like behavior in male C57BL/6 mice. | Wang X et al. | β | 2020 | β |
| MicroRNA-135a Protects Against Ethanol-Induced Apoptosis in Neural Crest Cells and Craniofacial Defects in Zebrafish by Modulating the Siah1/p38/p53 Pathway. | Yuan F et al. | β | 2020 | β |
| Ethanol exposed maturing rat cerebellar granule cells show impaired energy metabolism and increased cell death after oxygen-glucose deprivation. | Spataru A et al. | β | 2019 | β |
| Ethanol Exposure Increases miR-140 in Extracellular Vesicles: Implications for Fetal Neural Stem Cell Proliferation and Maturation. | Tseng AM et al. | β | 2019 | β |
| Genome-Wide Transcriptome Landscape of Embryonic Brain-Derived Neural Stem Cells Exposed to Alcohol with Strain-Specific Cross-Examination in BL6 and CD1 Mice. | Xu W et al. | β | 2019 | β |
| MicroRNA-34a mediates ethanol-induced impairment of neural differentiation of neural crest cells by targeting autophagy-related gene 9a. | Fan H et al. | β | 2019 | β |
| Toxicant and teratogenic effects of prenatal alcohol. | Mahnke AH et al. | β | 2019 | β |
| HMGB1/IL-1Ξ² complexes regulate neuroimmune responses in alcoholism. | Coleman LG et al. | β | 2018 | β |
| Plasminogen activator system homeostasis and its dysregulation by ethanol in astrocyte cultures and the developing brain. | Wilhelm CJ et al. | β | 2018 | β |
| Involvement of Wnt pathway in ethanol-induced inhibition of mouse embryonic stem cell differentiation. | Wang Q et al. | β | 2017 | β |
| Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal. | Walter TJ et al. | β | 2017 | β |
| Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7. | Coleman LG et al. | β | 2017 | β |
| Oleoylethanolamide prevents neuroimmune HMGB1/TLR4/NF-kB danger signaling in rat frontal cortex and depressive-like behavior induced by ethanol binge administration. | AntΓ³n M et al. | β | 2017 | β |
| The BAF (BRG1/BRM-Associated Factor) chromatin-remodeling complex exhibits ethanol sensitivity in fetal neural progenitor cells and regulates transcription at the miR-9-2 encoding gene locus. | Burrowes SG et al. | β | 2017 | β |
| Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling. | Ishii S et al. | β | 2017 | β |
| Astrocyte Dysfunction Induced by Alcohol in Females but Not Males. | Wilhelm CJ et al. | β | 2016 | β |
| Injured patients with very high blood alcohol concentrations. | Afshar M et al. | β | 2016 | β |
| Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases. | GarcΓa Bueno B et al. | β | 2016 | β |
| Alcohol exposure, injury, and death in trauma patients. | Afshar M et al. | β | 2015 | β |
| Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of Tamoxifen in Breast Cancer Cells. | Candelaria NR et al. | β | 2015 | β |
| Cytosolic phospholipase A2 regulates alcohol-mediated astrocyte inflammatory responses in HIV-associated neurocognitive disorders. | Pandey R et al. | β | 2015 | β |
| Ethanol deregulates Mecp2/MeCP2 in differentiating neural stem cells via interplay between 5-methylcytosine and 5-hydroxymethylcytosine at the Mecp2 regulatory elements. | Liyanage VR et al. | β | 2015 | β |
| Arylsulfatase B modulates neurite outgrowth via astrocyte chondroitin-4-sulfate: dysregulation by ethanol. | Zhang X et al. | β | 2014 | β |
| Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. | McClintick JN et al. | β | 2014 | β |
| Involvement of seven in absentia homolog-1 in ethanol-induced apoptosis in neural crest cells. | Sun H et al. | β | 2014 | β |
| MiR-153 targets the nuclear factor-1 family and protects against teratogenic effects of ethanol exposure in fetal neural stem cells. | Tsai PC et al. | β | 2014 | β |
| Neuroinflammation and neurodegeneration in adult rat brain from binge ethanol exposure: abrogation by docosahexaenoic acid. | Tajuddin N et al. | β | 2014 | β |
| Phospholipase A2, oxidative stress, and neurodegeneration in binge ethanol-treated organotypic slice cultures of developing rat brain. | Moon KH et al. | β | 2014 | β |
| Regulation of DNA methylation by ethanol induces tissue plasminogen activator expression in astrocytes. | Zhang X et al. | β | 2014 | β |
| Understanding the addiction cycle: a complex biology with distinct contributions of genotype vs. sex at each stage. | Wilhelm CJ et al. | β | 2014 | β |
| CD24 expression identifies teratogen-sensitive fetal neural stem cell subpopulations: evidence from developmental ethanol exposure and orthotopic cell transfer models. | Tingling JD et al. | β | 2013 | β |
| Cold-inducible RNA-binding protein is an important mediator of alcohol-induced brain inflammation. | Rajayer SR et al. | β | 2013 | β |
| Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice cultures. | Collins MA et al. | β | 2013 | β |
| Driving under the influence with blood alcohol concentrations over 0.4 g%. | Jones AW et al. | β | 2013 | β |
| Effect of repetitive daily ethanol intoxication on adult rat brain: significant changes in phospholipase A2 enzyme levels in association with increased PARP-1 indicate neuroinflammatory pathway activation. | Tajuddin NF et al. | β | 2013 | β |
| Hypoxic preconditioning alleviates ethanol neurotoxicity: the involvement of autophagy. | Wang H et al. | β | 2013 | β |
| Sulforaphane protects against ethanol-induced oxidative stress and apoptosis in neural crest cells by the induction of Nrf2-mediated antioxidant response. | Chen X et al. | β | 2013 | β |
| Suppression and epigenetic regulation of MiR-9 contributes to ethanol teratology: evidence from zebrafish and murine fetal neural stem cell models. | Pappalardo-Carter DL et al. | β | 2013 | β |
| Discontinuous versus continuous drinking of ethanol in peripubertal rats: effect on 24-hour pattern of hypophyseal-gonadal axis activity and anterior pituitary oxidative stress. | FernΓ‘ndez-Mateos P et al. | β | 2012 | β |
| Enforced Pax6 expression rescues alcohol-induced defects of neuronal differentiation in cultures of human cortical progenitor cells. | Mo Z et al. | β | 2012 | β |
| Ethanol affects differentiation-related pathways and suppresses Wnt signaling protein expression in human neural stem cells. | Vangipuram SD et al. | β | 2012 | β |
| Nuclear clusterin is associated with neuronal apoptosis in the developing rat brain upon ethanol exposure. | Kim N et al. | β | 2012 | β |
| Opposing actions of ethanol and nicotine on microRNAs are mediated by nicotinic acetylcholine receptors in fetal cerebral cortical-derived neural progenitor cells. | Balaraman S et al. | β | 2012 | β |
| Elevated testosterone in females reveals a robust sex difference in altered androgen levels during chronic alcohol withdrawal. | Forquer MR et al. | β | 2011 | β |
| Importance of genetic background for risk of relapse shown in altered prefrontal cortex gene expression during abstinence following chronic alcohol intoxication. | Hashimoto JG et al. | β | 2011 | β |
| A low ethanol dose affects all types of cells in mixed long-term embryonic cultures of the cerebellum. | Pickering C et al. | β | 2010 | β |
| Ethanol alters the osteogenic differentiation of amniotic fluid-derived stem cells. | Hipp JA et al. | β | 2010 | β |
| Induction of the Nrf2-driven antioxidant response by tert-butylhydroquinone prevents ethanol-induced apoptosis in cranial neural crest cells. | Yan D et al. | β | 2010 | β |
| MicroRNAs: master regulators of ethanol abuse and toxicity? | Miranda RC et al. | β | 2010 | β |
| Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage. | Alfonso-Loeches S et al. | β | 2010 | β |
| The role of acetaldehyde in human psychomotor function: a double-blind placebo-controlled crossover study. | Kim SW et al. | β | 2010 | β |
| The role of microRNAs in drug addiction: a big lesson from tiny molecules. | Pietrzykowski AZ | β | 2010 | β |
| The role of NOX enzymes in ethanol-induced oxidative stress and apoptosis in mouse embryos. | Dong J et al. | β | 2010 | β |
| Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA). | Brown J et al. | β | 2009 | β |
| Distinct cell proliferation events during abstinence after alcohol dependence: microglia proliferation precedes neurogenesis. | Nixon K et al. | β | 2008 | β |
| Ethanol increases fetal human neurosphere size and alters adhesion molecule gene expression. | Vangipuram SD et al. | β | 2008 | β |
| Modeling the impact of alcohol on cortical development in a dish: strategies from mapping neural stem cell fate. | Miranda RC et al. | β | 2008 | β |
| Neurotoxic consequences of chronic alcohol withdrawal: expression profiling reveals importance of gender over withdrawal severity. | Hashimoto JG et al. | β | 2008 | β |
| Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium. | Sathyan P et al. | β | 2007 | β |
| Embryonic cerebral cortical progenitors are resistant to apoptosis, but increase expression of suicide receptor DISC-complex genes and suppress autophagy following ethanol exposure. | Prock TL et al. | β | 2007 | β |
| Ethanol regulates angiogenic cytokines during neural development: evidence from an in vitro model of mitogen-withdrawal-induced cerebral cortical neuroepithelial differentiation. | Camarillo C et al. | β | 2007 | β |
| ALDH2 genotype-associated differences in the acute effects of alcohol on P300, psychomotor performance, and subjective response in healthy young Korean men: a double-blind placebo-controlled crossover study. | Shin HY et al. | β | 2006 | β |
| Biphasic changes in cardiac excitation-contraction coupling early in chronic alcohol exposure. | Aistrup GL et al. | β | 2006 | β |
| Alcohol-induced myocardial fibrosis in metallothionein-null mice: prevention by zinc supplementation. | Wang L et al. | β | 2005 | β |
| Ethanol induces cell-cycle activity and reduces stem cell diversity to alter both regenerative capacity and differentiation potential of cerebral cortical neuroepithelial precursors. | Santillano DR et al. | β | 2005 | β |
| Zinc prevention and treatment of alcoholic liver disease. | Kang YJ et al. | β | 2005 | β |
| Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes. | VallΓ©s SL et al. | β | 2004 | β |
| Human immunodeficiency virus type 1 gp120 and ethanol coexposure in rat organotypic brain slice cultures: Curtailment of gp120-induced neurotoxicity and neurotoxic mediators by moderate but not high ethanol concentrations. | Belmadani A et al. | β | 2003 | β |
| Alcohol and the mystique of flushing. | Chao HM | β | 1995 | β |