Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
paper
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- Authors
- Torgerson, Dara G; Ampleford, Elizabeth J; Chiu, Grace Y; Gauderman, W James; Gignoux, Christopher R; Graves, Penelope E; Himes, Blanca E; Levin, Albert M; Mathias, Rasika A; Hancock, Dana B; Baurley, James W; Eng, Celeste; Stern, Debra A; CeledΓ³n, Juan C; Rafaels, Nicholas; Capurso, Daniel; Conti, David V; Roth, Lindsey A; Soto-Quiros, Manuel; Togias, Alkis; Li, Xingnan; Myers, Rachel A; Romieu, Isabelle; Van Den Berg, David J; Hu, Donglei; Hansel, Nadia N; Hernandez, Ryan D; Israel, Elliott; Salam, Muhammad T; Galanter, Joshua; Avila, Pedro C; Avila, Lydiana; Rodriquez-Santana, Jose R; Chapela, Rocio; Rodriguez-Cintron, William; Diette, Gregory B; Adkinson, N Franklin; Abel, Rebekah A; Ross, Kevin D; Shi, Min; Faruque, Mezbah U; Dunston, Georgia M; Watson, Harold R; Mantese, Vito J; Ezurum, Serpil C; Liang, Liming; Ruczinski, Ingo; Ford, Jean G; Huntsman, Scott; Chung, Kian Fan; Vora, Hita; Li, Xia; Calhoun, William J; Castro, Mario; Sienra-Monge, Juan J; del Rio-Navarro, Blanca; Deichmann, Klaus A; Heinzmann, Andrea; Wenzel, Sally E; Busse, William W; Gern, James E; Lemanske, Robert F; Beaty, Terri H; Bleecker, Eugene R; Raby, Benjamin A; Meyers, Deborah A; London, Stephanie J; Mexico City Childhood Asthma Study (MCAAS); Gilliland, Frank D; Children's Health Study (CHS) and HARBORS study; Burchard, Esteban G; Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments (SAGE); Martinez, Fernando D; Childhood Asthma Research and Education (CARE) Network; Weiss, Scott T; Childhood Asthma Management Program (CAMP); Williams, L Keoki; Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE); Barnes, Kathleen C; Genetic Research on Asthma in African Diaspora (GRAAD) Study; Ober, Carole; Nicolae, Dan L
- Year
- 2011
- Journal
- Nature genetics
- PMID
- 21804549
- DOI
- 10.1038/ng.888
- PMCID
- PMC3445408
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 Γ 10(-9)). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.
Results of Meta-Analysis on the Chromosome 1 Region of Association in African Americans/African CaribbeansThe relative location of the PYHIN1 gene and direction of transcription are shown in the lower portion of the figure, and the chromosomal position on the x-axis. The light blue line shows the recombination rate across the region (right y-axis), and the left y-axis shows the significance of the associations. The large red diamond shows the p-value for rs1102000. The small diamonds in show the p-values for all other SNPs, color-coded according to the level of LD with rs1102000 in the HapMap YRI (red, r2 > 0.9; orange, r2 = 0.7β0.9; yellow, r2 = 0.5β0.7). Results for the European American, Latino, and combined meta-analysis are shown in Supplementary Fig. 6 online.
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|---|---|---|---|---|
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| Association study between IL-33 gene DNA methylation and Pediatric asthma. | Zhang Y et al. | β | 2026 | β |
| Context-specific genetic effects inform endotypes and treatment in asthma. | Dahl A et al. | β | 2026 | β |
| IL1RL1 rs11685480 polymorphism is associated with IL-33/IL1RL1 pathway activity and asthma severity in a Japanese population. | Hirai K et al. | β | 2026 | β |
| Thymic stromal lymphopoietin (TSLP) - pro-inflammatory cytokine and antimicrobial peptide. | DΓΆhner K et al. | β | 2026 | β |
| 131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma. | Saarentaus EC et al. | β | 2025 | β |
| A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthma. | Zhang Y et al. | β | 2025 | β |
| A Reassessment of the Genomic Ancestry of the World's Largest Captive Baboon Colony. | Mercuri G et al. | β | 2025 | β |
| Association of 17q12-q21 Asthma Risk Locus with Clinical Severity of Infant Respiratory Syncytial Virus Infection. | Turi KN et al. | β | 2025 | β |
| Association of cord blood vitamin D and genetic polymorphisms with childhood food allergy in Shanghai, China: a prospective cohort. | Wang X et al. | β | 2025 | β |
| Bioaerosols and Airway Diseases: Mechanisms of Epithelial Dysfunction, Immune Activation, and Strategies for Exposure Mitigation. | Nabipur L et al. | β | 2025 | β |
| Demographic and regional mortality trends in patients with asthma in the United States (1999-2020): a CDC WONDER analysis. | Ahmed S et al. | β | 2025 | β |
| DNA methylation: a potential mediator between air pollution exposures and asthma control. | Nguyen MN et al. | β | 2025 | β |
| Eosinophils and pleural macrophages counter regulate IL-33-elicited airway inflammation via the 12/15-lipoxygenase pathway. | Ito E et al. | β | 2025 | β |
| From itchy skin to wheezing: Potential biomarkers and targeted drugs for atopic dermatitis and asthma in children. | Zheng X et al. | β | 2025 | β |
| Functional sequence variants of intergenic long noncoding RNA on chromosome 17q21 are associated with asthma. | Liu KY et al. | β | 2025 | β |
| Innate Immunity and Asthma Exacerbations: Insights From Human Models. | Alladina J et al. | β | 2025 | β |
| Integrated analysis reveals that EGR1 promotes epithelial IL33 production in T2 asthma. | Zhao Y et al. | β | 2025 | β |
| Key role of thymic stromal lymphopoietin as a molecular target for biologic treatment of severe asthma. | Pelaia C et al. | β | 2025 | β |
| Massively parallel analysis of genotype-dependent enhancer activity among atopic dermatitis genetic risk variants. | Shook MS et al. | β | 2025 | β |
| Potential of alarmin-targeted bispecific and combination therapies in airway disease. | Komori HK et al. | β | 2025 | β |
| Predictive Factors and Clinical Markers of Recurrent Wheezing and Asthma After RSV Infection. | Buttarelli L et al. | β | 2025 | β |
| Regulatory T cells and their role in allergic disease. | Conrad ML et al. | β | 2025 | β |
| Sex differences in asthma: omics evidence and future directions. | Peng B et al. | β | 2025 | β |
| Super Partition: fast, flexible, and interpretable large-scale data reduction in R. | Queen KJ et al. | β | 2025 | β |
| Targeting alarmins in asthma: From bench to clinic. | Akenroye A et al. | β | 2025 | β |
| Unraveling the heterogeneity of asthma: Decoding subtypes of asthma. | Fuhlbrigge AL et al. | β | 2025 | β |
| Unveiling genetic links: GSDMB polymorphisms and asthma susceptibility in the Zhuang Nationality of Guangxi. | Li H et al. | β | 2025 | β |
| Accounting for heterogeneity due to environmental sources in meta-analysis of genome-wide association studies. | Wang S et al. | β | 2024 | β |
| Advances in non-type 2 severe asthma: from molecular insights to novel treatment strategies. | Liu T et al. | β | 2024 | β |
| Analytical challenges in omics research on asthma and allergy: AΒ National Institute of Allergy and Infectious Diseases workshop. | Bunyavanich S et al. | β | 2024 | β |
| Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling. | Fields JK et al. | β | 2024 | β |
| Association between interleukin-6-174G/C gene polymorphism and asthma severity: exploring the role of total serum IgE, blood eosinophils, and FeNO as markers of type 2 inflammation. | Al-Ahmad M et al. | β | 2024 | β |
| Bronchial epithelial transcriptomics and experimental validation reveal asthma severity-related neutrophilc signatures and potential treatments. | Yan Q et al. | β | 2024 | β |
| Exploring TSLP and IL-33 Serum Levels and Genetic Variants: Unveiling Their Limited Potential as Biomarkers for Mild Asthma in Children. | PoΕomska J et al. | β | 2024 | β |
| From Pathogenesis to Treatment: Targeting Type-2 Inflammation in Eosinophilic Esophagitis. | Barchi A et al. | β | 2024 | β |
| Genetics of chronic respiratory disease. | Sayers I et al. | β | 2024 | β |
| Mast cells control lung type 2 inflammation via prostaglandin E<sub>2</sub>-driven soluble ST2. | Alhallak K et al. | β | 2024 | β |
| Multifactorial Causes and Consequences of TLSP Production, Function, and Release in the Asthmatic Airway. | Brister DL et al. | β | 2024 | β |
| Selective production of IL-33-neutralizing autoantibody ameliorates asthma responses and severity. | Ji Y et al. | β | 2024 | β |
| Sphingolipid classes and the interrelationship with pediatric asthma and asthma risk factors. | Chen Y et al. | β | 2024 | β |
| A20 is a master switch of IL-33 signaling in macrophages and determines IL-33-induced lung immunity. | Holgado A et al. | β | 2023 | β |
| ACDC: a general approach for detecting phenotype or exposure associated co-expression. | Queen K et al. | β | 2023 | β |
| A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies <i>ANXA1</i> as a susceptibility locus for persistent wheezing. | Granell R et al. | β | 2023 | β |
| An in-depth association analysis of genetic variants within nicotine-related loci: Meeting in middle of GWAS and genetic fine-mapping. | Mo C et al. | β | 2023 | β |
| Asthma susceptibility: Learning from genetic diversity. | Sun Y et al. | β | 2023 | β |
| Biobank-scale methods and projections for sparse polygenic prediction from machine learning. | Raben TG et al. | β | 2023 | β |
| Decoding the genetic and epigenetic basis of asthma. | Stikker BS et al. | β | 2023 | β |
| Development of an inhaled anti-TSLP therapy for asthma. | O'Byrne PM et al. | β | 2023 | β |
| Disparities in Asthma Rates Amongst Black Residents of New York City. | Monteau R et al. | β | 2023 | β |
| Evaluating significance of European-associated index SNPs in the East Asian population for 31 complex phenotypes. | Qiao J et al. | β | 2023 | β |
| Exploring the significance of interleukin-33/ST2 axis in minimal change disease. | Kanazawa N et al. | β | 2023 | β |
| From gene identifications to therapeutic targets for asthma: Focus on great potentials of <i>TSLP, ORMDL3</i>, and <i>GSDMB</i>. | Zhang Y | β | 2023 | β |
| Group 2 innate lymphoid cells in human asthma. | Iwata A et al. | β | 2023 | β |
| Human lung virtual histology by multi-scale x-ray phase-contrast computed tomography. | Reichmann J et al. | β | 2023 | β |
| ILC2 require cell-intrinsic ST2 signals to promote type 2 immune responses. | Topczewska PM et al. | β | 2023 | β |
| Immunogenetics and pharmacogenetics of allergic asthma in Africa. | Mabelane T et al. | β | 2023 | β |
| Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation. | Saarentaus EC et al. | β | 2023 | β |
| Laundry detergents and surfactants-induced eosinophilic airway inflammation by increasing IL-33 expression and activating ILC2s. | Saito K et al. | β | 2023 | β |
| Metabolomics identifies disturbances in arginine, phenylalanine, and glycine metabolism as differentiating features of exacerbating atopic asthma in children. | Cottrill KA et al. | β | 2023 | β |
| Relationship between depression severity and respiratory symptoms in US adults: A national cross-sectional study. | Sun Y et al. | β | 2023 | β |
| Role of thymic stromal lymphopoietin in allergy and beyond. | Ebina-Shibuya R et al. | β | 2023 | β |
| Severe Asthmatic Responses: The Impact of TSLP. | Theofani E et al. | β | 2023 | β |
| Strategies targeting IL-33/ST2 axis in the treatment of allergic diseases. | Li W et al. | β | 2023 | β |
| Targeting interleukin-33 and thymic stromal lymphopoietin pathways for novel pulmonary therapeutics in asthma and COPD. | Calderon AA et al. | β | 2023 | β |
| The Dual Role of the Airway Epithelium in Asthma: Active Barrier and Regulator of Inflammation. | Frey A et al. | β | 2023 | β |
| The Influence of Sex Hormones and X Chromosome in Immune Responses. | Anesi N et al. | β | 2023 | β |
| The Legacy of Infectious Disease Exposure on the Genomic Diversity of Indigenous Southern Mexicans. | Garcia OA et al. | β | 2023 | β |
| Tissue-resident innate lymphoid cells in asthma. | Wang X et al. | β | 2023 | β |
| TRAF4 is crucial for ST2+ memory Th2 cell expansion in IL-33-driven airway inflammation. | Xiao J et al. | β | 2023 | β |
| Transgenerational epigenetic inheritance: Perspectives and challenges. | Niu Z et al. | β | 2023 | β |
| TSLP and HMGB1: Inflammatory Targets and Potential Biomarkers for Precision Medicine in Asthma and COPD. | Furci F et al. | β | 2023 | β |
| Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation. | Gandhi VD et al. | β | 2022 | β |
| A pathogenic integrated view explaining the different endotypes of asthma and allergic disorders. | Maggi E et al. | β | 2022 | β |
| A pilot study of differential gene expressions in patients with cough variant asthma and classic bronchial asthma. | Zhou G et al. | β | 2022 | β |
| A Poisson reduced-rank regression model for association mapping in sequencing data. | Fitzgerald T et al. | β | 2022 | β |
| Asthma and the Missing Heritability Problem: Necessity for Multiomics Approaches in Determining Accurate Risk Profiles. | Augustine T et al. | β | 2022 | β |
| Asthma Susceptibility Gene <i>ORMDL3</i> Promotes Autophagy in Human Bronchial Epithelium. | Guo F et al. | β | 2022 | β |
| Cellular and molecular mechanisms of allergic asthma. | KomlΓ³si ZI et al. | β | 2022 | β |
| Discerning asthma endotypes through comorbidity mapping. | Jia G et al. | β | 2022 | β |
| Editorial comments on: "Multi-ancestry genome-wide association study of asthma exacerbations". | Birben E et al. | β | 2022 | β |
| Epithelial immune regulation of inflammatory airway diseases: ChronicΒ rhinosinusitis with nasal polypsΒ (CRSwNP). | Klimek L et al. | β | 2022 | β |
| Genetics of Asthma and Allergic Diseases. | Haider S et al. | β | 2022 | β |
| How the Immune System Responds to Allergy Immunotherapy. | Veneziani I et al. | β | 2022 | β |
| IL-33 Induces an Antiviral Signature in Mast Cells but Enhances Their Permissiveness for Human Rhinovirus Infection. | Akoto C et al. | β | 2022 | β |
| ILCs and Allergy. | Kabata H et al. | β | 2022 | β |
| Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine. | Cayrol C et al. | β | 2022 | β |
| Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity. | Tsuo K et al. | β | 2022 | β |
| Multiomics analysis identifies BIRC3 as a novel glucocorticoid response-associated gene. | Kan M et al. | β | 2022 | β |
| Multi-Omics Profiling Approach to Asthma: An Evolving Paradigm. | Gautam Y et al. | β | 2022 | β |
| Pyrroloquinoline Quinone Administration Alleviates Allergic Airway Inflammation in Mice by Regulating the JAK-STAT Signaling Pathway. | Min Z et al. | β | 2022 | β |
| Targeting androgen signaling in ILC2s protects from IL-33-driven lung inflammation, independently of KLRG1. | Blanquart E et al. | β | 2022 | β |
| The Role of Systems Biology in Deciphering Asthma Heterogeneity. | Hachim MY et al. | β | 2022 | β |
| The Therapeutic Potential for Targeting Group 2 Innate Lymphoid Cells in Asthma. | Matsuyama T et al. | β | 2022 | β |
| TSLP disease-associated genetic variants combined with airway TSLP expression influence asthma risk. | Murrison LB et al. | β | 2022 | β |
| Type 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood. | Dong Z et al. | β | 2022 | β |
| Vulnerability to acid reflux of the airway epithelium in severe asthma. | Perotin JM et al. | β | 2022 | β |
| Advances in the genomics of ANCA-associated vasculitis-a view from East Asia. | Kawasaki A et al. | β | 2021 | β |
| A genome-wide association study of asthma hospitalizations in adults. | Yan Q et al. | β | 2021 | β |
| A genome-wide association study of severe asthma exacerbations in Latino children and adolescents. | Yan Q et al. | β | 2021 | β |
| Airway smooth muscle pathophysiology in asthma. | Camoretti-Mercado B et al. | β | 2021 | β |
| An Overview of Health Disparities in Asthma. | Perez MF et al. | β | 2021 | β |
| Association between Green Space Structure and the Prevalence of Asthma: A Case Study of Toronto. | Dong Y et al. | β | 2021 | β |
| Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region. | Aneas I et al. | β | 2021 | β |
| Asthma Prevalence and its Risk Factors Among a Multi-Ethnic Adult Population. | Jeyagurunathan A et al. | β | 2021 | β |
| Barrier Impairment and Type 2 Inflammation in Allergic Diseases: The Pediatric Perspective. | Ghezzi M et al. | β | 2021 | β |
| Current Knowledge of Asthma-COPD Overlap (ACO) Genetic Risk Factors, Characteristics, and Prognosis. | Odimba U et al. | β | 2021 | β |
| Diversity and the Splice of Life: Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African American Individuals. | Raby BA et al. | β | 2021 | β |
| Estrogen receptor-Ξ± signaling increases allergen-induced IL-33 release and airway inflammation. | Cephus JY et al. | β | 2021 | β |
| Generation and Characterization of Torudokimab (LY3375880): A Monoclonal Antibody That Neutralizes Interleukin-33. | Okragly AJ et al. | β | 2021 | β |
| Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways. | Li X et al. | β | 2021 | β |
| Genetic ancestry differences in pediatric asthma readmission are mediated by socioenvironmental factors. | Mersha TB et al. | β | 2021 | β |
| Genetic Architecture of Depression: Where Do We Stand Now? | Unal-Aydin P et al. | β | 2021 | β |
| Genetics and Epigenetics in Allergic Rhinitis. | Choi BY et al. | β | 2021 | β |
| Genetics and Epigenetics in Asthma. | Ntontsi P et al. | β | 2021 | β |
| Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children. | Akenroye AT et al. | β | 2021 | β |
| Genome-Wide Association Study of Korean Asthmatics: A Comparison With UK Asthmatics. | An J et al. | β | 2021 | β |
| Home environment allergen exposure scale in older adult cohort with asthma. | Castner J et al. | β | 2021 | β |
| IL1RL1 single nucleotide polymorphisms are associated with asthma in the Iranian population. | Ranjbar M et al. | β | 2021 | β |
| Inducible expression quantitative trait locus analysis of the MUC5AC gene in asthma in urban populations of children. | Altman MC et al. | β | 2021 | β |
| Interleukin-18, IL-18 binding protein and IL-18 receptor expression in asthma: a hypothesis showing IL-18 promotes epithelial cell differentiation. | Kaur D et al. | β | 2021 | β |
| LTA4H rs2660845 association with montelukast response in early and late-onset asthma. | Maroteau C et al. | β | 2021 | β |
| Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans. | Gui H et al. | β | 2021 | β |
| Microbiome Research and Multi-Omics Integration for Personalized Medicine in Asthma. | Logotheti M et al. | β | 2021 | β |
| Milestones of Precision Medicine: An Innovative, Multidisciplinary Overview. | GarcΓa-Foncillas J et al. | β | 2021 | β |
| Monoclonal Antibodies Targeting Alarmins: A New Perspective for Biological Therapies of Severe Asthma. | Pelaia C et al. | β | 2021 | β |
| Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus. | Soliai MM et al. | β | 2021 | β |
| Pathogenic helper T cells. | Hirahara K et al. | β | 2021 | β |
| Potential Metabolic Biomarkers in Adult Asthmatics. | Sim S et al. | β | 2021 | β |
| Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank. | Valette K et al. | β | 2021 | β |
| Prostaglandin I2 signaling licenses Treg suppressive function and prevents pathogenic reprogramming. | Norlander AE et al. | β | 2021 | β |
| Race and Genetic Ancestry in Medicine - A Time for Reckoning with Racism. | Borrell LN et al. | β | 2021 | β |
| Resolving Clinical Phenotypes into Endotypes in Allergy: Molecular and Omics Approaches. | Mersha TB et al. | β | 2021 | β |
| Structural racism and readmission for childhood asthma-a quest for causality. | Ege MJ | β | 2021 | β |
| Tezepelumab: A Potential New Biological Therapy for Severe Refractory Asthma. | Pelaia C et al. | β | 2021 | β |
| The Interleukin-33-Group 2 Innate Lymphoid Cell Axis Represents a Potential Adjuvant Target To Increase the Cross-Protective Efficacy of Influenza Vaccine. | Williams CM et al. | β | 2021 | β |
| Thymic stromal lymphopoietin, skin barrier dysfunction, and the atopic march. | Ziegler SF | β | 2021 | β |
| Translational Analysis of Moderate to Severe Asthma GWAS Signals Into Candidate Causal Genes and Their Functional, Tissue-Dependent and Disease-Related Associations. | Portelli MA et al. | β | 2021 | β |
| TSLP as druggable target - a silver-lining for atopic diseases? | Adhikary PP et al. | β | 2021 | β |
| US Childhood Asthma Incidence Rate Patterns From the ECHO Consortium to Identify High-risk Groups for Primary Prevention. | Johnson CC et al. | β | 2021 | β |
| Adult-onset eosinophilic airway diseases. | Asano K et al. | β | 2020 | β |
| A genome-wide association study on medulloblastoma. | Dahlin AM et al. | β | 2020 | β |
| Anti-alarmin approaches entering clinical trials. | Gauvreau GM et al. | β | 2020 | β |
| Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses. | Nakajima S et al. | β | 2020 | β |
| Association of Single-Nucleotide Polymorphisms With Chronic Rhinosinusitis in a Southwestern Han Chinese Population: A Replication Study. | Xu Y et al. | β | 2020 | β |
| Asthma genetics revisited: understanding disease mechanisms by studying ethnically diverse groups. | MelΓ©n E | β | 2020 | β |
| Asthma/Rhinitis (The United Airway) and Allergy: Chicken or Egg; Which Comes First? | Warner JO | β | 2020 | β |
| Comprehensive functional annotation of susceptibility variants associated with asthma. | Gautam Y et al. | β | 2020 | β |
| Contributions of IL-33 in Non-hematopoietic Lung Cells to Obstructive Lung Disease. | Drake LY et al. | β | 2020 | β |
| Detecting Genotype-Population Interaction Effects by Ancestry Principal Components. | Yu C et al. | β | 2020 | β |
| Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome. | Maiorino E et al. | β | 2020 | β |
| Discovery through Diversity: Insights into the Genetics of Lung Function in Latino Youth. | Jones TK et al. | β | 2020 | β |
| Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy. | McGeachie MJ et al. | β | 2020 | β |
| Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study. | Ober C et al. | β | 2020 | β |
| Gene-Environment Interaction between the <i>IL1RN</i> Variants and Childhood Environmental Tobacco Smoke Exposure in Asthma Risk. | Shao Y et al. | β | 2020 | β |
| Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa. | Laulajainen-Hongisto A et al. | β | 2020 | β |
| Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse Model. | Yasuda Y et al. | β | 2020 | β |
| Gut Microbial-Derived Metabolomics of Asthma. | Lee-Sarwar KA et al. | β | 2020 | β |
| IL-33 in Chronic Respiratory Disease: From Preclinical to Clinical Studies. | Donovan C et al. | β | 2020 | β |
| Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets. | Dong Z et al. | β | 2020 | β |
| Integrative genomics analysis of various omics data and networks identify risk genes and variants vulnerable to childhood-onset asthma. | Ma X et al. | β | 2020 | β |
| Interplay Between the IL-33/ST2 Axis and Bone Marrow ILC2s in Protease Allergen-Induced IL-5-Dependent Eosinophilia. | Boberg E et al. | β | 2020 | β |
| Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma. | Depner M et al. | β | 2020 | β |
| Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and asthmatic airway epithelium. | Portelli MA et al. | β | 2020 | β |
| Prodromal clinical, demographic, and socio-ecological correlates of asthma in adults: a 10-year statewide big data multi-domain analysis. | Fishe JN et al. | β | 2020 | β |
| PYHIN1 regulates pro-inflammatory cytokine induction rather than innate immune DNA sensing in airway epithelial cells. | Massa D et al. | β | 2020 | β |
| Recent findings in the genetics and epigenetics of asthma and allergy. | Kabesch M et al. | β | 2020 | β |
| Single-nucleotide polymorphisms and haplotypes in the interleukin-33 gene are associated with a risk of allergic rhinitis in the Chinese population. | Ran H et al. | β | 2020 | β |
| Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation. | Kabata H et al. | β | 2020 | β |
| The Airway Epithelium-A Central Player in Asthma Pathogenesis. | CalvΓ©n J et al. | β | 2020 | β |
| The role of innate immunity in asthma development and protection: Lessons from the environment. | Pivniouk V et al. | β | 2020 | β |
| The Utility of Resolving Asthma Molecular Signatures Using Tissue-Specific Transcriptome Data. | Ghosh D et al. | β | 2020 | β |
| Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma. | Gauvreau GM et al. | β | 2020 | β |
| Unmet need in severe, uncontrolled asthma: can anti-TSLP therapy with tezepelumab provide a valuable new treatment option? | Menzies-Gow A et al. | β | 2020 | β |
| A chalcone derivative suppresses the induction of TSLP in mice and human keratinocytes and attenuates OVA-induced antibody production in mice. | Segawa R et al. | β | 2019 | β |
| Advances in asthma and allergic disease genetics: Is bigger always better? | Schoettler N et al. | β | 2019 | β |
| African American ancestry contribution to asthma and atopic dermatitis. | Daya M et al. | β | 2019 | β |
| A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma. | Spear ML et al. | β | 2019 | β |
| A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity. | Maazi H et al. | β | 2019 | β |
| An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos. | Gignoux CR et al. | β | 2019 | β |
| An integrative association method for omics data based on a modified Fisher's method with application to childhood asthma. | Yan Q et al. | β | 2019 | β |
| Association of IL1RL1 rs3771180 and TSLP rs1837253 variants with asthma in the Guangxi Zhuang population in China. | Sun Y et al. | β | 2019 | β |
| Association of Polymorphisms at the SIX1-SIX6 Locus With Primary Open-Angle Glaucoma. | Lu SY et al. | β | 2019 | β |
| Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. | Daya M et al. | β | 2019 | β |
| Asthma in Children and Adults-What Are the Differences and What Can They Tell us About Asthma? | Trivedi M et al. | β | 2019 | β |
| BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications. | Weathington N et al. | β | 2019 | β |
| Caesarean section and children's health: A quasi-experimental design. | Polos J et al. | β | 2019 | β |
| Contributions of Innate Lymphoid Cells in Chronic Rhinosinusitis. | Luong AU et al. | β | 2019 | β |
| Deconstructing the sex bias in allergy and autoimmunity: From sex hormones and beyond. | Laffont S et al. | β | 2019 | β |
| Ecological determinants of respiratory health: Examining associations between asthma emergency department visits, diesel particulate matter, and public parks and open space in Los Angeles, California. | Douglas JA et al. | β | 2019 | β |
| Eleven loci with new reproducible genetic associations with allergic disease risk. | Ferreira MAR et al. | β | 2019 | β |
| Environment and Host-Genetic Determinants in Early Development of Allergic Asthma: Contribution of Fungi. | Hadebe S et al. | β | 2019 | β |
| Epigenome-wide association study reveals methylation pathways associated with childhood allergic sensitization. | Peng C et al. | β | 2019 | β |
| Epithelial cell-derived cytokines: more than just signaling the alarm. | Roan F et al. | β | 2019 | β |
| ERS/EAACI statement on severe exacerbations in asthma in adults: facts, priorities and key research questions. | Bourdin A et al. | β | 2019 | β |
| Genetic profiling for disease stratification in chronic obstructive pulmonary disease and asthma. | Rathnayake SNH et al. | β | 2019 | β |
| Genetic risk factors for the development of pulmonary disease identified by genome-wide association. | Hall R et al. | β | 2019 | β |
| Genome-wide association studies of structural birth defects: A review and commentary. | Lupo PJ et al. | β | 2019 | β |
| Genomic Predictors of Asthma Phenotypes and Treatment Response. | Hernandez-Pacheco N et al. | β | 2019 | β |
| Group 2 Innate Lymphoid Cells in Airway Diseases. | Kato A | β | 2019 | β |
| High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report. | Hersh CP et al. | β | 2019 | β |
| How does race and ethnicity effect the precision treatment of asthma? | Zhang E et al. | β | 2019 | β |
| IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation. | Allinne J et al. | β | 2019 | β |
| IL-33 Mediated Inflammation in Chronic Respiratory Diseases-Understanding the Role of the Member of IL-1 Superfamily. | Gabryelska A et al. | β | 2019 | β |
| IL33: Roles in Allergic Inflammation and Therapeutic Perspectives. | Chan BCL et al. | β | 2019 | β |
| Integrative approach identifies corticosteroid response variant in diverse populations with asthma. | Levin AM et al. | β | 2019 | β |
| Interactions between polycyclic aromatic hydrocarbons and epoxide hydrolase 1 play roles in asthma. | Wang Q et al. | β | 2019 | β |
| Interleukin-33 in the developing lung-Roles in asthma and infection. | Johansson K et al. | β | 2019 | β |
| Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults. | Dahlin A et al. | β | 2019 | β |
| Lessons Learned From GWAS of Asthma. | Kim KW et al. | β | 2019 | β |
| Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. | Shrine N et al. | β | 2019 | β |
| Nocturnal asthma is affected by genetic interactions between RORA and NPSR1. | Gaertner VD et al. | β | 2019 | β |
| OCTN2-Mediated Acetyl-l-Carnitine Transport in Human Pulmonary Epithelial Cells In Vitro. | Salomon JJ et al. | β | 2019 | β |
| Pilot GWAS of caries in African-Americans shows genetic heterogeneity. | Orlova E et al. | β | 2019 | β |
| Proinflammatory Pathways in the Pathogenesis of Asthma. | Peebles RS et al. | β | 2019 | β |
| Reconstructing recent population history while mapping rare variants using haplotypes. | Yunusbaev U et al. | β | 2019 | β |
| Relationship of common variants in Interleukin 33 gene with susceptibility and prognosis of osteosarcoma in Han Chinese population. | Kang C et al. | β | 2019 | β |
| Rhinovirus Attributes that Contribute to Asthma Development. | Han M et al. | β | 2019 | β |
| Sex-associated TSLP-induced immune alterations following early-life RSV infection leads to enhanced allergic disease. | Malinczak CA et al. | β | 2019 | β |
| Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. | Zhu Z et al. | β | 2019 | β |
| Short-term effect of PM<sub>2.5</sub> on pediatric asthma incidence in Shanghai, China. | Ma Y et al. | β | 2019 | β |
| The Advantages and Challenges of Diversity in Pharmacogenomics: Can Minority Populations Bring Us Closer to Implementation? | Zhang H et al. | β | 2019 | β |
| The airway epithelium in asthma. | Bonser LR et al. | β | 2019 | β |
| The discovery of novel mechanisms for lymphangioleiomyomatosis pathogenesis through GWAS: a rarity in rare respiratory disorders. | Kristof AS et al. | β | 2019 | β |
| The Future of Genomic Studies Must Be Globally Representative: Perspectives from PAGE. | Bien SA et al. | β | 2019 | β |
| The role of the 17q21 genotype in the prevention of early childhood asthma and recurrent wheeze by vitamin D. | Kelly RS et al. | β | 2019 | β |
| The SLC transporter in nutrient and metabolic sensing, regulation, and drug development. | Zhang Y et al. | β | 2019 | β |
| TSLP and TSLP receptors variants are associated with smoking. | Semlali A et al. | β | 2019 | β |
| TSLP: from allergy to cancer. | Corren J et al. | β | 2019 | β |
| Use of precision cut lung slices as a translational model for the study of lung biology. | Liu G et al. | β | 2019 | β |
| Validation of childhood asthma predictive tools: A systematic review. | Colicino S et al. | β | 2019 | β |
| What did we learn from multiple omics studies in asthma? | Ivanova O et al. | β | 2019 | β |
| Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma. | Kachroo P et al. | β | 2019 | β |
| A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. | Stein MM et al. | β | 2018 | β |
| After asthma: redefining airways diseases. | Pavord ID et al. | β | 2018 | β |
| A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis. | Panganiban RA et al. | β | 2018 | β |
| A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. | Zhu Z et al. | β | 2018 | β |
| All along the watchtower: group 2 innate lymphoid cells in allergic responses. | Dahlgren MW et al. | β | 2018 | β |
| An Integrative Transcriptomic and Metabolomic Study of Lung Function in Children With Asthma. | Kelly RS et al. | β | 2018 | β |
| Antialarmins for treatment of asthma: future perspectives. | Al-Sajee D et al. | β | 2018 | β |
| Assessing Asthma Medication Responses in U.S. Minority Children by Whole-Genome Sequencing. | Lorenzo-Salazar JM et al. | β | 2018 | β |
| Assessment of genetic factor and depression interactions for asthma symptom severity in cohorts of childhood and elderly asthmatics. | Park HW et al. | β | 2018 | β |
| Association of ST2 polymorphisms with atopy, asthma, and leukemia. | Bloodworth MH et al. | β | 2018 | β |
| Blood Eosinophil Count and Metabolic, Cardiac and Pulmonary Outcomes: A Mendelian Randomization Study. | Amini M et al. | β | 2018 | β |
| Bone marrow type 2 innate lymphoid cells: a local source of interleukin-5 in interleukin-33-driven eosinophilia. | Johansson K et al. | β | 2018 | β |
| Changing the threshold-Signals and mechanisms of mast cell priming. | Halova I et al. | β | 2018 | β |
| Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study. | Hayden LP et al. | β | 2018 | β |
| DNA methylation in childhood asthma: an epigenome-wide meta-analysis. | Xu CJ et al. | β | 2018 | β |
| Eosinophilic esophagitis (EoE) genetic susceptibility is mediated by synergistic interactions between EoE-specific and general atopic disease loci. | Martin LJ et al. | β | 2018 | β |
| Eosinophils from Physiology to Disease: A Comprehensive Review. | Ramirez GA et al. | β | 2018 | β |
| Established and Emerging Environmental Contributors to Disparities in Asthma and Chronic Obstructive Pulmonary Disease. | Levy JI et al. | β | 2018 | β |
| Food allergen triggers are increased in children with the TSLP risk allele and eosinophilic esophagitis. | Fahey LM et al. | β | 2018 | β |
| Gene Coexpression Networks in Whole Blood Implicate Multiple Interrelated Molecular Pathways in Obesity in People with Asthma. | Croteau-Chonka DC et al. | β | 2018 | β |
| Gene editing in the context of an increasingly complex genome. | Blighe K et al. | β | 2018 | β |
| Genetic Determinants of Telomere Length in African American Youth. | Zeiger AM et al. | β | 2018 | β |
| Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search. | Kogan V et al. | β | 2018 | β |
| Genetic Mechanisms of Asthma and the Implications for Drug Repositioning. | Huo Y et al. | β | 2018 | β |
| Genetic regulation of <i>IL1RL1</i> methylation and IL1RL1-a protein levels in asthma. | Dijk FN et al. | β | 2018 | β |
| Genetics of Exfoliation Syndrome. | Aung T et al. | β | 2018 | β |
| Genome-wide association study of self-reported food reactions in Japanese identifies shrimp and peach specific loci in the HLA-DR/DQ gene region. | Khor SS et al. | β | 2018 | β |
| Glucocorticoid Receptor Binding Inhibits an Intronic <i>IL33</i> Enhancer and is Disrupted by rs4742170 (T) Allele Associated with Specific Wheezing Phenotype in Early Childhood. | Gorbacheva AM et al. | β | 2018 | β |
| Identification of deleterious and regulatory genomic variations in known asthma loci. | Neville MDC et al. | β | 2018 | β |
| IL-33 gene variants and protein expression in pediatric Tunisian asthmatic patients. | Charrad R et al. | β | 2018 | β |
| IL-33 signalling contributes to pollutant-induced allergic airway inflammation. | De Grove KC et al. | β | 2018 | β |
| IL-33/ST2 Pathway as a Rational Therapeutic Target for CNS Diseases. | Du LX et al. | β | 2018 | β |
| Inhibiting Glycolysis and ATP Production Attenuates IL-33-Mediated Mast Cell Function and Peritonitis. | Caslin HL et al. | β | 2018 | β |
| Insights in particulate matter-induced allergic airway inflammation: Focus on the epithelium. | De Grove KC et al. | β | 2018 | β |
| Insights into respiratory disease through bioinformatics. | Hurgobin B et al. | β | 2018 | β |
| Interleukin 33 ameliorates disturbance of regulatory T cells in pulmonary sarcoidosis. | Zhang B et al. | β | 2018 | β |
| Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family. | Cayrol C et al. | β | 2018 | β |
| Mast cell-dependent IL-33/ST2 signaling is protective against the development of airway hyperresponsiveness in a house dust mite mouse model of asthma. | Zoltowska Nilsson AM et al. | β | 2018 | β |
| Microarray data analysis to identify differentially expressed genes and biological pathways associated with asthma. | Qi S et al. | β | 2018 | β |
| Modulation of Allergic Reactivity in Humans Is Dependent on <i>Schistosoma mansoni</i> Parasite Burden, Low Levels of IL-33 or TNF-Ξ± and High Levels of IL-10 in Serum. | Resende SD et al. | β | 2018 | β |
| Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. | Demenais F et al. | β | 2018 | β |
| Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function. | Wyss AB et al. | β | 2018 | β |
| Nasal epithelium as a proxy for bronchial epithelium for smoking-induced gene expression and expression Quantitative Trait Loci. | Imkamp K et al. | β | 2018 | β |
| Novel eosinophilic gene expression networks associated with IgE in two distinct asthma populations. | Virkud YV et al. | β | 2018 | β |
| Nursing Practice and Particulate Matter Exposure. | Castner J et al. | β | 2018 | β |
| Orchestration of epithelial-derived cytokines and innate immune cells in allergic airway inflammation. | Castillo EF et al. | β | 2018 | β |
| Precision Medicine in Targeted Therapies for Severe Asthma: Is There Any Place for "Omics" Technology? | Galeone C et al. | β | 2018 | β |
| Role of epigenetics in the development of childhood asthma. | Davidson EJ et al. | β | 2018 | β |
| Sequence variant analysis of RNA sequences in severe equine asthma. | Tessier L et al. | β | 2018 | β |
| Small Molecule Mimetics of Ξ±-Helical Domain of IRAK2 Attenuate the Proinflammatory Effects of IL-33 in Asthma-like Mouse Models. | Li J et al. | β | 2018 | β |
| The clinical imperative for inclusivity: Race, ethnicity, and ancestry (REA) in genomics. | Popejoy AB et al. | β | 2018 | β |
| The effects of caregiver depression on childhood asthma: Pathways and mechanisms. | Wood BL et al. | β | 2018 | β |
| The Genetics and Genomics of Asthma. | Willis-Owen SAG et al. | β | 2018 | β |
| The Risk G Allele of the Single-Nucleotide Polymorphism rs928413 Creates a CREB1-Binding Site That Activates <i>IL33</i> Promoter in Lung Epithelial Cells. | Gorbacheva AM et al. | β | 2018 | β |
| Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer. | Varricchi G et al. | β | 2018 | β |
| 10 Years of GWAS Discovery: Biology, Function, and Translation. | Visscher PM et al. | β | 2017 | β |
| Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma. | KlaΓen C et al. | β | 2017 | β |
| Allergic diseases: From bench to clinic - Contribution of the discovery of interleukin-5. | Yanagibashi T et al. | β | 2017 | β |
| A meta-analysis of genome-wide association studies of asthma in PuertoΒ Ricans. | Yan Q et al. | β | 2017 | β |
| Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1Ξ²-, IL-18- and sirtuin-1-independent pathways. | Li YF et al. | β | 2017 | β |
| An intronic single-nucleotide polymorphism (rs13217795) in FOXO3 is associated with asthma and allergic rhinitis: a case-case-control study. | Amarin JZ et al. | β | 2017 | β |
| A pathway-based association study reveals variants from Wnt signalling genes contributing to asthma susceptibility. | Barreto-Luis A et al. | β | 2017 | β |
| A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma. | Smith D et al. | β | 2017 | β |
| Archaic Hominin Introgression in Africa Contributes to Functional Salivary MUC7 Genetic Variation. | Xu D et al. | β | 2017 | β |
| Are ILC2s Jekyll and Hyde in airway inflammation? | Ealey KN et al. | β | 2017 | β |
| Association between IL-13 +1923C/T polymorphism and asthma risk: a meta-analysis based on 26 case-control studies. | Xu Y et al. | β | 2017 | β |
| Asthma phenotypes in childhood. | Deliu M et al. | β | 2017 | β |
| Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IL-33-induced cytokine production in primary mouse mast cells. | Caslin HL et al. | β | 2017 | β |
| Disease-Specific Integration of Omics Data to Guide Functional Validation of Genetic Associations. | Shumyatcher M et al. | β | 2017 | β |
| Dysregulation of type 2 innate lymphoid cells and T<sub>H</sub>2 cells impairs pollutant-induced allergic airway responses. | De Grove KC et al. | β | 2017 | β |
| Effects of Allergic Sensitization on Antiviral Immunity: Allergen, Virus, and Host Cell Mechanisms. | Rowe RK et al. | β | 2017 | β |
| Enhancing Electronic Health Record Data with Geospatial Information. | Xie S et al. | β | 2017 | β |
| Epigenetic regulation of <i>AXL</i> and risk of childhood asthma symptoms. | Gao L et al. | β | 2017 | β |
| Gender-specific determinants of asthma among U.S. adults. | Greenblatt R et al. | β | 2017 | β |
| Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling. | Ferreira MA et al. | β | 2017 | β |
| Gene expression analysis in asthma using a targeted multiplex array. | Pascoe CD et al. | β | 2017 | β |
| Gene Expression Profiling in Blood Provides Reproducible Molecular Insights into Asthma Control. | Croteau-Chonka DC et al. | β | 2017 | β |
| Genetic variants and risk of asthma in an American Indian population. | Best LG et al. | β | 2017 | β |
| Hygiene Hypothesis in Asthma Development: Is Hygiene to Blame? | van Tilburg Bernardes E et al. | β | 2017 | β |
| Identification of Four Novel Loci in Asthma in European American and African American Populations. | Almoguera B et al. | β | 2017 | β |
| IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population. | Queiroz GA et al. | β | 2017 | β |
| IL-33: biological properties, functions, and roles in airway disease. | Drake LY et al. | β | 2017 | β |
| Immune development and environment: lessons from Amish and Hutterite children. | Ober C et al. | β | 2017 | β |
| Innate lymphoid cells: major players in inflammatory diseases. | Ebbo M et al. | β | 2017 | β |
| Interleukin 33 exacerbates antigen driven airway hyperresponsiveness, inflammation and remodeling in a mouse model of asthma. | SjΓΆberg LC et al. | β | 2017 | β |
| Lessons from ten years of genome-wide association studies of asthma. | Vicente CT et al. | β | 2017 | β |
| Linking childhood allergic asthma phenotypes with endotype through integrated systems biology: current evidence and research needs. | Choi H et al. | β | 2017 | β |
| Making progress toward understanding the genetic architecture of asthma in the most affected US ethnic group. | Himes BE et al. | β | 2017 | β |
| Memory-type ST2<sup>+</sup>CD4<sup>+</sup> T cells participate in the steroid-resistant pathology of eosinophilic pneumonia. | Mato N et al. | β | 2017 | β |
| Microbial Insights into Asthmatic Immunopathology. A Forward-Looking Synthesis and Commentary. | Boutin RCT et al. | β | 2017 | β |
| MicroRNA-145 down-regulates mucin 5AC to alleviate airway remodeling and targets EGFR to inhibit cytokine expression. | Cheng Z et al. | β | 2017 | β |
| MicroRNA-155 is a critical regulator of type 2 innate lymphoid cells and IL-33 signaling in experimental models of allergic airway inflammation. | Johansson K et al. | β | 2017 | β |
| Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme. | Pissios P | β | 2017 | β |
| NOD2 promotes cell proliferation and inflammatory response by mediating expression of TSLP in human airway smooth muscle cells. | Ni G et al. | β | 2017 | β |
| On a Collision Course: The Electronic Medical Record and Genetic Studies of Asthma. | Ortega VE et al. | β | 2017 | β |
| PAI-1 gain-of-function genotype, factors increasing PAI-1 levels, and airway obstruction: The GALA II Cohort. | Sherenian MG et al. | β | 2017 | β |
| Pathogenic T cell subsets in allergic and chronic inflammatory bowel disorders. | Zundler S et al. | β | 2017 | β |
| Personalised medicine in asthma: from curative to preventive medicine. | Guilleminault L et al. | β | 2017 | β |
| Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients. | Loxham M et al. | β | 2017 | β |
| Polygenic risk assessment reveals pleiotropy between sarcoidosis and inflammatory disorders in the context of genetic ancestry. | Lareau CA et al. | β | 2017 | β |
| Predicting Severe Asthma Exacerbations in Children. | Puranik S et al. | β | 2017 | β |
| Predictors of emergency department use in children with persistent asthma in metropolitan Atlanta, Georgia. | Franklin JM et al. | β | 2017 | β |
| Regulatory T cells and type 2 innate lymphoid cell-dependent asthma. | Aron JL et al. | β | 2017 | β |
| Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma. | Verstraete K et al. | β | 2017 | β |
| The environment, epigenome, and asthma. | Yang IV et al. | β | 2017 | β |
| The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice. | Han M et al. | β | 2017 | β |
| Thymic stromal lymphopoietin and apocynin alter the expression of airway remodeling factors in human rhinovirus-infected cells. | Wieczfinska J et al. | β | 2017 | β |
| Transferability of genome-wide associated loci for asthma in African Americans. | Faruque MU et al. | β | 2017 | β |
| Using omics approaches to understand pulmonary diseases. | Kan M et al. | β | 2017 | β |
| When Innate Responses Matter: ILC2s Loom Large in Allergic Airway Inflammation. | Vercelli D | β | 2017 | β |
| 17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells. | Schmiedel BJ et al. | β | 2016 | β |
| ADRB2 polymorphisms in allergic asthma in Han Chinese children. | Tian M et al. | β | 2016 | β |
| Airway Epithelial Expression Quantitative Trait Loci Reveal Genes Underlying Asthma and Other Airway Diseases. | Luo W et al. | β | 2016 | β |
| Alternate-locus aware variant calling in whole genome sequencing. | JΓ€ger M et al. | β | 2016 | β |
| A Player and Coordinator: The Versatile Roles of Eosinophils in the Immune System. | Long H et al. | β | 2016 | β |
| Applications of Molecular Genetics to the Study of Asthma. | Sanz-Lozano CS et al. | β | 2016 | β |
| Association Between Gasdermin A and Gasdermin B Polymorphisms and Susceptibility to Adult and Childhood Asthma Among Jordanians. | Zihlif M et al. | β | 2016 | β |
| Asthma Genetics in the Post-GWAS Era. | Ober C | β | 2016 | β |
| Asthma susceptibility variants are more strongly associated with clinically similar subgroups. | Lavoie-Charland E et al. | β | 2016 | β |
| Combining genomewide association study and lung eQTL analysis provides evidence for novel genes associated with asthma. | Nieuwenhuis MA et al. | β | 2016 | β |
| Complex genetics of pulmonary diseases: lessons from genome-wide association studies and next-generation sequencing. | Pouladi N et al. | β | 2016 | β |
| DNA methylation in lung cells is associated with asthma endotypes and genetic risk. | Nicodemus-Johnson J et al. | β | 2016 | β |
| Explaining the disease phenotype of intergenic SNP through predicted long range regulation. | Chen J et al. | β | 2016 | β |
| Exploring the Major Sources and Extent of Heterogeneity in a Genome-Wide Association Meta-Analysis. | Pei YF et al. | β | 2016 | β |
| Expression of asthma susceptibility genes in bronchial epithelial cells and bronchial alveolar lavage in the Severe Asthma Research Program (SARP) cohort. | Li X et al. | β | 2016 | β |
| Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis. | Andiappan AK et al. | β | 2016 | β |
| Genetic effects of multiple asthma loci identified by genomewide association studies on asthma and spirometric indices. | Tang MF et al. | β | 2016 | β |
| Genetic variation in uncontrolled childhood asthma despite ICS treatment. | Leusink M et al. | β | 2016 | β |
| Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene. | Barreto-Luis A et al. | β | 2016 | β |
| Heritability and confirmation of genetic association studies for childhood asthma in twins. | Ullemar V et al. | β | 2016 | β |
| Human demographic history impacts genetic risk prediction across diverse populations | Martin AR et al. | β | 2016 | β |
| IL-33 and Thymic Stromal Lymphopoietin in mast cell functions. | Saluja R et al. | β | 2016 | β |
| Increased expression of nuclear factor of activated TΒ cells 1 drives IL-9-mediated allergic asthma. | Koch S et al. | β | 2016 | β |
| Innate lymphoid cells in asthma: Will they take your breath away? | Kim HY et al. | β | 2016 | β |
| Integrated analyses of gene expression and genetic association studies in a founder population. | Cusanovich DA et al. | β | 2016 | β |
| Interleukin-33 from Monocytes Recruited to the Lung Contributes to House Dust Mite-Induced Airway Inflammation in a Mouse Model. | Tashiro H et al. | β | 2016 | β |
| Interleukin-33 in health and disease. | Liew FY et al. | β | 2016 | β |
| KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex. | Johnson EO et al. | β | 2016 | β |
| Leveraging gene-environment interactions and endotypes for asthma gene discovery. | BΓΈnnelykke K et al. | β | 2016 | β |
| Local genotype influences DNA methylation at two asthma-associated regions, 5q31 and 17q21, in a founder effect population. | Al Tuwaijri A et al. | β | 2016 | β |
| <i>IL1RL1</i> asthma risk variants regulate airway type 2 inflammation. | Gordon ED et al. | β | 2016 | β |
| Novel genetic risk factors for asthma in African American children: Precision Medicine and the SAGE II Study. | White MJ et al. | β | 2016 | β |
| Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung. | de Kleer IM et al. | β | 2016 | β |
| Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children's Health Study. | Breton CV et al. | β | 2016 | β |
| Pulmonary Disease and Age at Immigration among Hispanics. Results from the Hispanic Community Health Study/Study of Latinos. | Barr RG et al. | β | 2016 | β |
| Regulation of IL-4 Expression in Immunity and Diseases. | Ho IC et al. | β | 2016 | β |
| Resolving the etiology of atopic disorders by using genetic analysis of racial ancestry. | Gupta J et al. | β | 2016 | β |
| Severe Asthma in Children: Lessons Learned and Future Directions. | Fitzpatrick AM | β | 2016 | β |
| Soluble ST2 suppresses the effect of interleukin-33 on lung type 2 innate lymphoid cells. | Hayakawa H et al. | β | 2016 | β |
| The genetic and epigenetic landscapes of the epithelium in asthma. | Moheimani F et al. | β | 2016 | β |
| The interleukin-33 receptor ST2 is important for the development of peripheral airway hyperresponsiveness and inflammation in a house dust mite mouse model of asthma. | Zoltowska AM et al. | β | 2016 | β |
| TSLP polymorphisms, allergen exposures, and the risk of atopic disorders in children. | Wang IJ et al. | β | 2016 | β |
| Type 2 innate lymphoid cells: at the cross-roads in allergic asthma. | van Rijt L et al. | β | 2016 | β |
| Unsupervised text mining for assessing and augmenting GWAS results. | Ailem M et al. | β | 2016 | β |
| What Ancestry Can Tell Us About the Genetic Origins of Inter-Ethnic Differences in Asthma Expression. | Hernandez-Pacheco N et al. | β | 2016 | β |
| A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma. | Sharma A et al. | β | 2015 | β |
| A Generalized Sequential Bonferroni Procedure for GWAS in Admixed Populations Incorporating Admixture Mapping Information into Association Tests. | Chen W et al. | β | 2015 | β |
| An allergist's perspective to the evaluation of Eosinophilic Esophagitis. | Spergel JM | β | 2015 | β |
| Association between adverse childhood experiences in the home and pediatric asthma. | Wing R et al. | β | 2015 | β |
| Association Between TSLP Polymorphisms and Eczema in Japanese Women: the Kyushu Okinawa Maternal and Child Health Study. | Miyake Y et al. | β | 2015 | β |
| Asthma in Latin America. | Forno E et al. | β | 2015 | β |
| Asthma: the interplay between viral infections and allergic diseases. | Rowe RK et al. | β | 2015 | β |
| Can probiotics be used to treat allergic diseases? | Tang RB et al. | β | 2015 | β |
| Contributing factors to the development of childhood asthma: working toward risk minimization. | Guibas GV et al. | β | 2015 | β |
| Discovering susceptibility genes for allergic rhinitis and allergy using a genome-wide association study strategy. | Li J et al. | β | 2015 | β |
| Dusp5 negatively regulates IL-33-mediated eosinophil survival and function. | Holmes DA et al. | β | 2015 | β |
| Emerging molecular phenotypes of asthma. | Ray A et al. | β | 2015 | β |
| eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes. | Li X et al. | β | 2015 | β |
| Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma. | Igartua C et al. | β | 2015 | β |
| Exome analysis of patients with concurrent pediatric inflammatory bowel disease and autoimmune disease. | Andreoletti G et al. | β | 2015 | β |
| Expression Quantitative Trait Loci Information Improves Predictive Modeling of Disease Relevance of Non-Coding Genetic Variation. | Croteau-Chonka DC et al. | β | 2015 | β |
| Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent. | Acosta-Herrera M et al. | β | 2015 | β |
| Genes associated with RSV lower respiratory tract infection and asthma: the application of genetic epidemiological methods to understand causality. | Larkin EK et al. | β | 2015 | β |
| Genetic ancestry influences asthma susceptibility and lung function among Latinos. | Pino-Yanes M et al. | β | 2015 | β |
| [Genetic and biochemical mechanisms of involvement of antioxidant defense enzymes in the development of bronchial asthma]. | Polonikov AV et al. | β | 2015 | β |
| Genetic and epigenetic studies of <i>FOXP3</i> in asthma and allergy. | Marques CR et al. | β | 2015 | β |
| Genetic risk factors for the development of allergic disease identified by genome-wide association. | Portelli MA et al. | β | 2015 | β |
| Genetics of allergic diseases. | Ortiz RA et al. | β | 2015 | β |
| Genetics of allergy and allergic sensitization: common variants, rare mutations. | BΓΈnnelykke K et al. | β | 2015 | β |
| Genetic variants of inducible costimulator are associated with allergic asthma susceptibility. | Andiappan AK et al. | β | 2015 | β |
| Genetic variation in HTR4 and lung function: GWAS follow-up in mouse. | House JS et al. | β | 2015 | β |
| Genome-wide association studies in Africans and African Americans: expanding the framework of the genomics of human traits and disease. | Peprah E et al. | β | 2015 | β |
| Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos. | Pino-Yanes M et al. | β | 2015 | β |
| Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. | Hong X et al. | β | 2015 | β |
| Group 2 innate lymphoid cells and asthma. | Kabata H et al. | β | 2015 | β |
| iGWAS: Integrative Genome-Wide Association Studies of Genetic and Genomic Data for Disease Susceptibility Using Mediation Analysis. | Huang YT et al. | β | 2015 | β |
| Interleukin-33 and its Receptor in Pulmonary Inflammatory Diseases. | Zhao J et al. | β | 2015 | β |
| Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist's Perspective. | Jang TY et al. | β | 2015 | β |
| Interleukin-33 exacerbates allergic bronchoconstriction in the mice via activation of mast cells. | SjΓΆberg LC et al. | β | 2015 | β |
| Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. | Molofsky AB et al. | β | 2015 | β |
| Mapping asthma-associated variants in admixed populations. | Mersha TB | β | 2015 | β |
| Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins. | Murphy TM et al. | β | 2015 | β |
| Novel genetic locus implicated for HIV-1 acquisition with putative regulatory links to HIV replication and infectivity: a genome-wide association study. | Johnson EO et al. | β | 2015 | β |
| Pathobiology of severe asthma. | Trejo Bittar HE et al. | β | 2015 | β |
| Phenotypic and genotypic association of epithelial IL1RL1 to human TH2-like asthma. | Traister RS et al. | β | 2015 | β |
| Polymorphisms of RAD50, IL33 and IL1RL1 are associated with atopic asthma in Chinese population. | Chen J et al. | β | 2015 | β |
| Potential effector and immunoregulatory functions of mast cells in mucosal immunity. | Reber LL et al. | β | 2015 | β |
| Powerful Tests for Multi-Marker Association Analysis Using Ensemble Learning. | Padhukasahasram B et al. | β | 2015 | β |
| Racial and Ethnic Disparities in Research Studies: The Challenge of Creating More Diverse Cohorts. | Konkel L | β | 2015 | β |
| Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33. | CalvΓ©n J et al. | β | 2015 | β |
| Should lung biopsies be performed in patients with severe asthma? | Doberer D et al. | β | 2015 | β |
| Systems biology of asthma and allergic diseases: a multiscale approach. | Bunyavanich S et al. | β | 2015 | β |
| The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway. | Endo Y et al. | β | 2015 | β |
| The messenger between worlds: the regulation of innate and adaptive type-2 immunity by innate lymphoid cells. | Scanlon ST et al. | β | 2015 | β |
| The role of antioxidants in the chemistry of oxidative stress: A review. | Pisoschi AM et al. | β | 2015 | β |
| The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders. | Saluja R et al. | β | 2015 | β |
| Thymic stromal lymphopoietin signaling in CD4(+) T cells is required for TH2 memory. | Wang Q et al. | β | 2015 | β |
| Thymic stromal lymphopoietin (TSLP) secretion from human nasal epithelium is a function of TSLP genotype. | Hui CC et al. | β | 2015 | β |
| Transcriptome analysis of controlled and therapy-resistant childhood asthma reveals distinct gene expression profiles. | Persson H et al. | β | 2015 | β |
| 17q21 locus and ORMDL3: an increased risk for childhood asthma. | Ono JG et al. | β | 2014 | β |
| A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA. | MΓ‘rquez A et al. | β | 2014 | β |
| A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. | BΓΈnnelykke K et al. | β | 2014 | β |
| A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes. | Sharma S et al. | β | 2014 | β |
| Airway epithelial barrier function regulates the pathogenesis of allergic asthma. | Heijink IH et al. | β | 2014 | β |
| Antioxidant defense enzyme genes and asthma susceptibility: gender-specific effects and heterogeneity in gene-gene interactions between pathogenetic variants of the disease. | Polonikov AV et al. | β | 2014 | β |
| Association between tumor necrosis factor-Ξ± rs1800629 polymorphism and risk of asthma: a meta-analysis. | Yang G et al. | β | 2014 | β |
| Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood. | Savenije OE et al. | β | 2014 | β |
| Asthma genetics 2014: reaching for high-hanging fruit. | Koppelman GH et al. | β | 2014 | β |
| Asthma genetics and personalised medicine. | Meyers DA et al. | β | 2014 | β |
| Asthma in Hispanics. An 8-year update. | Rosser FJ et al. | β | 2014 | β |
| Asthma: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. | Jackson DJ et al. | β | 2014 | β |
| A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa. | Melum GR et al. | β | 2014 | β |
| Attention to local health burden and the global disparity of health research. | Evans JA et al. | β | 2014 | β |
| Childhood asthma: recent developments and update. | Mantzouranis E et al. | β | 2014 | β |
| Clinical and epidemiologic phenotypes of childhood asthma. | Depner M et al. | β | 2014 | β |
| Damage-associated molecular patterns stimulate interleukin-33 expression in nasal polyp epithelial cells. | Paris G et al. | β | 2014 | β |
| Defining the roles of IL-33, thymic stromal lymphopoietin, and IL-25 in human asthma. | Byers DE | β | 2014 | β |
| Dissecting childhood asthma with nasal transcriptomics distinguishes subphenotypes of disease. | Poole A et al. | β | 2014 | β |
| Early-life viral infections and the development of asthma: a target for asthma prevention? | Jackson DJ | β | 2014 | β |
| Early origins of chronic obstructive lung diseases across the life course. | Duijts L et al. | β | 2014 | β |
| Effects of antioxidant supplements and nutrients on patients with asthma and allergies. | Moreno-Macias H et al. | β | 2014 | β |
| Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma. | Biagini Myers JM et al. | β | 2014 | β |
| Evidence of heterogeneity by race/ethnicity in genetic determinants of QT interval. | Seyerle AA et al. | β | 2014 | β |
| Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. | van der Valk RJ et al. | β | 2014 | β |
| Functional Fcgamma receptor polymorphisms are associated with human allergy. | Wu J et al. | β | 2014 | β |
| Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population groups. | Padhukasahasram B et al. | β | 2014 | β |
| Genetic heterogeneity of asthma phenotypes identified by a clustering approach. | Siroux V et al. | β | 2014 | β |
| Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis. | Li C et al. | β | 2014 | β |
| Genetic variation of TBX21 gene increases risk of asthma and its severity in Indian children. | Sharma N et al. | β | 2014 | β |
| Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. | Ferreira MA et al. | β | 2014 | β |
| Genome-wide association studies of atopic dermatitis. | Tamari M et al. | β | 2014 | β |
| Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study. | Galanter JM et al. | β | 2014 | β |
| Genome-wide interaction studies reveal sex-specific asthma risk alleles. | Myers RA et al. | β | 2014 | β |
| GWAS identifies four novel eosinophilic esophagitis loci. | Sleiman PM et al. | β | 2014 | β |
| Human genetics. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits. | Moreno-Estrada A et al. | β | 2014 | β |
| IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy. | Cayrol C et al. | β | 2014 | β |
| Immune mechanisms and development of childhood asthma. | Raedler D et al. | β | 2014 | β |
| Implications of population structure and ancestry on asthma genetic studies. | Ortega VE et al. | β | 2014 | β |
| Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33. | Lai Y et al. | β | 2014 | β |
| Innate lymphoid cells in asthma: when innate immunity comes in a Th2 flavor. | Vercelli D et al. | β | 2014 | β |
| Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. | Bunyavanich S et al. | β | 2014 | β |
| Integrative genetic analysis of allergic inflammation in the murine lung. | Kelada SN et al. | β | 2014 | β |
| International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. | Chung KF et al. | β | 2014 | β |
| Introduction to genetics and genomics in asthma: genetics of asthma. | Mathias RA | β | 2014 | β |
| Molecular biology of atopic dermatitis. | Mu Z et al. | β | 2014 | β |
| Neighborhood, family, and childhood and adolescent epilepsy: a nationwide epidemiological study from Sweden. | Li X et al. | β | 2014 | β |
| On individual genome-wide association studies and their meta-analysis. | Pei YF et al. | β | 2014 | β |
| Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis. | Namjou B et al. | β | 2014 | β |
| Revisiting fatal asthma. | Traister RS et al. | β | 2014 | β |
| Stress and asthma: novel insights on genetic, epigenetic, and immunologic mechanisms. | Rosenberg SL et al. | β | 2014 | β |
| Structural basis of the proinflammatory signaling complex mediated by TSLP. | Verstraete K et al. | β | 2014 | β |
| Th17 cells demonstrate stable cytokine production in a proallergic environment. | Glosson-Byers NL et al. | β | 2014 | β |
| The cell biology of asthma. | Erle DJ et al. | β | 2014 | β |
| The clinical and genetic features of COPD-asthma overlap syndrome. | Hardin M et al. | β | 2014 | β |
| The emerging role of human PYHIN proteins in innate immunity: implications for health and disease. | Connolly DJ et al. | β | 2014 | β |
| The genetic variants of thymic stromal lymphopoietin protein in children with asthma and allergic rhinitis. | Birben E et al. | β | 2014 | β |
| The importance of TSLP in allergic disease and its role as a potential therapeutic target. | Cianferoni A et al. | β | 2014 | β |
| The role of airway epithelial cells and innate immune cells in chronic respiratory disease. | Holtzman MJ et al. | β | 2014 | β |
| The Wuhan-Zhuhai (WHZH) cohort study of environmental air particulate matter and the pathogenesis of cardiopulmonary diseases: study design, methods and baseline characteristics of the cohort. | Song Y et al. | β | 2014 | β |
| Thymic stromal lymphopoietin: a central regulator of allergic asthma. | Watson B et al. | β | 2014 | β |
| Trans-ethnic genome-wide association studies: advantages and challenges of mapping in diverse populations. | Li YR et al. | β | 2014 | β |
| Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma. | Campbell CD et al. | β | 2014 | β |
| A distinct sensitization pattern associated with asthma and the thymic stromal lymphopoietin (TSLP) genotype. | Iijima H et al. | β | 2013 | β |
| A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. | Hinds DA et al. | β | 2013 | β |
| A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. | Weidinger S et al. | β | 2013 | β |
| Allergic rhinitis, chronic rhinosinusitis and asthma: unravelling a complex relationship. | Kariyawasam HH et al. | β | 2013 | β |
| A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. | Levin AM et al. | β | 2013 | β |
| Assessing the validity of asthma associations for eight candidate genes and age at diagnosis effects. | Pino-Yanes M et al. | β | 2013 | β |
| Association between ADAM33 S2 and ST+4 polymorphisms and susceptibility to asthma: a meta-analysis. | Song GG et al. | β | 2013 | β |
| Asthma. | Martinez FD et al. | β | 2013 | β |
| A twin study of early-childhood asthma in Puerto Ricans. | Bunyavanich S et al. | β | 2013 | β |
| Biomedical research, a tool to address the health issues that affect African populations. | Peprah E et al. | β | 2013 | β |
| Body mass index, asthma, and genetic variation. | Tobin MD | β | 2013 | β |
| [Bronchial asthma: progress in diagnosis and treatments. Topics: II. Pathogenesis and pathophysiology; 2. Genes associated with asthma and asthma-related phenotypes]. | Hizawa N | β | 2013 | β |
| Central role of cellular senescence in TSLP-induced airway remodeling in asthma. | Wu J et al. | β | 2013 | β |
| Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies. | Wang X et al. | β | 2013 | β |
| Copy number variation prevalence in known asthma genes and their impact on asthma susceptibility. | Rogers AJ et al. | β | 2013 | β |
| Decoding asthma: translating genetic variation in IL33 and IL1RL1 into disease pathophysiology. | Grotenboer NS et al. | β | 2013 | β |
| Environmental and genetic contribution in airway epithelial barrier in asthma pathogenesis. | Tsicopoulos A et al. | β | 2013 | β |
| Finding novel genes by testing G Γ E interactions in a genome-wide association study. | Gauderman WJ et al. | β | 2013 | β |
| Genetic polymorphisms and associated susceptibility to asthma. | March ME et al. | β | 2013 | β |
| Genetics of onset of asthma. | Dijk FN et al. | β | 2013 | β |
| Genetic variations of the FCER2 gene and asthma susceptibility in north Indian children: a case-control study. | Sharma N et al. | β | 2013 | β |
| Genome-wide association studies in asthma; perhaps, the end of the beginning. | Lockett GA et al. | β | 2013 | β |
| Genome-wide association studies in asthma: what they really told us about pathogenesis. | Wjst M et al. | β | 2013 | β |
| Genome-wide association studies of allergic diseases. | Tamari M et al. | β | 2013 | β |
| Genome-Wide Association Studies of Allergic Diseases. | Tamari M et al. | β | 2013 | β |
| Genome-wide association study for levels of total serum IgE identifies HLA-C in a Japanese population. | Yatagai Y et al. | β | 2013 | β |
| Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. | Li X et al. | β | 2013 | β |
| Genome-wide association study of body mass index in 23 000 individuals with and without asthma. | MelΓ©n E et al. | β | 2013 | β |
| Genome-wide expression quantitative trait loci analysis in asthma. | BossΓ© Y | β | 2013 | β |
| Group 2 innate lymphoid cells in lung inflammation. | Li BW et al. | β | 2013 | β |
| High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. | Ellinghaus D et al. | β | 2013 | β |
| IL-1 family cytokines drive Th2 and Th17 cells to innocuous airborne antigens. | Kobayashi T et al. | β | 2013 | β |
| IL-33-dependent induction of allergic lung inflammation by FcΞ³RIII signaling. | Tjota MY et al. | β | 2013 | β |
| Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity. | Worgall TS et al. | β | 2013 | β |
| Implications for Interleukin-33 in solid organ transplantation. | Liu Q et al. | β | 2013 | β |
| Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. | Himes BE et al. | β | 2013 | β |
| Integrative genetic and metabolite profiling analysis suggests altered phosphatidylcholine metabolism in asthma. | Ried JS et al. | β | 2013 | β |
| Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma. | Acevedo N et al. | β | 2013 | β |
| Investigating highly replicated asthma genes as candidate genes for allergic rhinitis. | Andiappan AK et al. | β | 2013 | β |
| ITGB5 and AGFG1 variants are associated with severity of airway responsiveness. | Himes BE et al. | β | 2013 | β |
| Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease. | Byers DE et al. | β | 2013 | β |
| Mast cells and IgE: from history to today. | Saito H et al. | β | 2013 | β |
| Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease. | Hirahara K et al. | β | 2013 | β |
| MicroRNA-375 regulation of thymic stromal lymphopoietin by diesel exhaust particles and ambient particulate matter in human bronchial epithelial cells. | Bleck B et al. | β | 2013 | β |
| New kids on the block: group 2 innate lymphoid cells and type 2 inflammation in the lung. | Halim TYF et al. | β | 2013 | β |
| Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. | Xu H et al. | β | 2013 | β |
| Personalised medicine and asthma diagnostics/management. | Wadsworth SJ et al. | β | 2013 | β |
| Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes. | McGeachie MJ et al. | β | 2013 | β |
| Predicting cell types and genetic variations contributing to disease by combining GWAS and epigenetic data. | Gerasimova A et al. | β | 2013 | β |
| Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations. | Ding L et al. | β | 2013 | β |
| Reaching beyond disparity: safely improving asthma control in the at-risk African-American population. | Brown RW et al. | β | 2013 | β |
| Replication and fine mapping of asthma-associated loci in individuals of African ancestry. | Kantor DB et al. | β | 2013 | β |
| Role of interactions in pharmacogenetic studies: leukotrienes in asthma. | Via M et al. | β | 2013 | β |
| Rule-based models of the interplay between genetic and environmental factors in childhood allergy. | BornelΓΆv S et al. | β | 2013 | β |
| Sex- and age-dependent DNA methylation at the 17q12-q21 locus associated with childhood asthma. | Naumova AK et al. | β | 2013 | β |
| [Targeted therapies in severe asthma: the discovery of new molecules]. | Charriot J et al. | β | 2013 | β |
| The biology of thymic stromal lymphopoietin (TSLP). | Ziegler SF et al. | β | 2013 | β |
| The correlation analysis of two common polymorphisms in STAT6 gene and the risk of asthma: a meta-analysis. | Zhu L et al. | β | 2013 | β |
| The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin. | Weaver CT et al. | β | 2013 | β |
| Type 2 innate lymphocytes in allergic airway inflammation. | Klein Wolterink RG et al. | β | 2013 | β |
| Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population. | Tomita K et al. | β | 2013 | β |
| African ancestry is associated with asthma risk in African Americans. | Flores C et al. | β | 2012 | β |
| Antiviral IFN-Ξ³ responses of monocytes at birth predict respiratory tract illness in the first year of life. | Sumino K et al. | β | 2012 | β |
| Assessment of genotype imputation performance using 1000 Genomes in African American studies. | Hancock DB et al. | β | 2012 | β |
| Asthma: a chronic infectious disease? | Caramori G et al. | β | 2012 | β |
| Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens. | Holtzman MJ | β | 2012 | β |
| Asthma Research for All of the United States. | Nguyen EA et al. | β | 2012 | β |
| Asthma: the paradox of heterogeneity. | Drazen JM | β | 2012 | β |
| Case-control admixture mapping in Latino populations enriches for known asthma-associated genes. | Torgerson DG et al. | β | 2012 | β |
| Clinical Use of Probiotics in Pediatric Allergy (CUPPA): A World Allergy Organization Position Paper. | Fiocchi A et al. | β | 2012 | β |
| Dynamic role of epithelium-derived cytokines in asthma. | Bartemes KR et al. | β | 2012 | β |
| Epigenetics and childhood asthma: current evidence and future research directions. | Salam MT et al. | β | 2012 | β |
| Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. | Brunette RL et al. | β | 2012 | β |
| Fetal and infant origins of asthma. | Duijts L | β | 2012 | β |
| Functions of thymic stromal lymphopoietin in immunity and disease. | Zhang Y et al. | β | 2012 | β |
| Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. | Myers RA et al. | β | 2012 | β |
| Gene-environment interactions in asthma and allergic diseases: challenges and perspectives. | Kauffmann F et al. | β | 2012 | β |
| Genetic ancestry and its association with asthma exacerbations among African American subjects with asthma. | Rumpel JA et al. | β | 2012 | β |
| Genetic basis for personalized medicine in asthma. | Portelli M et al. | β | 2012 | β |
| Genetic, epigenetic, and environmental factors in asthma and allergy. | Blumenthal MN | β | 2012 | β |
| Genetics of asthma susceptibility and severity. | Slager RE et al. | β | 2012 | β |
| Genetic variation and the risk of asthma: does it drive the differences in asthma prevalence among ethnic groups in North America? | Pilger D et al. | β | 2012 | β |
| Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. | Himes BE et al. | β | 2012 | β |
| Genome-wide association studies and prediction of normal tissue toxicity. | West CM et al. | β | 2012 | β |
| Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases. | Li X et al. | β | 2012 | β |
| Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. | Ramasamy A et al. | β | 2012 | β |
| Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. | Hirota T et al. | β | 2012 | β |
| Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. | Hancock DB et al. | β | 2012 | β |
| Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort. | Spycher BD et al. | β | 2012 | β |
| Gut matters: microbe-host interactions in allergic diseases. | HΓΆrmannsperger G et al. | β | 2012 | β |
| Health disparities in asthma. | Forno E et al. | β | 2012 | β |
| HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults. | Lasky-Su J et al. | β | 2012 | β |
| IL-1 receptor-associated kinase 3 gene (IRAK3) variants associate with asthma in a replication study in the Spanish population. | Pino-Yanes M et al. | β | 2012 | β |
| Immunologic therapeutic interventions in asthma: impact on natural history. | Bourdin A et al. | β | 2012 | β |
| Interleukin 13 and the evolution of asthma therapy. | GrΓΌnig G et al. | β | 2012 | β |
| Lung eQTLs to help reveal the molecular underpinnings of asthma. | Hao K et al. | β | 2012 | β |
| Mast Cells Respond to Cell Injury through the Recognition of IL-33. | Lunderius-Andersson C et al. | β | 2012 | β |
| Pathogenesis of severe asthma. | Poon AH et al. | β | 2012 | β |
| Pathophysiology of asthma: lessons from genetic research with particular focus on severe asthma. | MelΓ©n E et al. | β | 2012 | β |
| Population-based case-control association studies. | Hancock DB et al. | β | 2012 | β |
| Power comparison of admixture mapping and direct association analysis in genome-wide association studies. | Qin H et al. | β | 2012 | β |
| Resequencing candidate genes implicates rare variants in asthma susceptibility. | Torgerson DG et al. | β | 2012 | β |
| Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. | Jarjour NN et al. | β | 2012 | β |
| The Childhood Asthma Management Program (CAMP): Contributions to the Understanding of Therapy and the Natural History of Childhood Asthma. | Covar RA et al. | β | 2012 | β |
| The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes. | Cusanovich DA et al. | β | 2012 | β |
| The investigation of severe asthma to define phenotypes. | Gibeon D et al. | β | 2012 | β |
| The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond. | Roan F et al. | β | 2012 | β |
| The Peru Urban versus Rural Asthma (PURA) Study: methods and baseline quality control data from a cross-sectional investigation into the prevalence, severity, genetics, immunology and environmental factors affecting asthma in adolescence in Peru. | Robinson CL et al. | β | 2012 | β |
| The role of CFTR mutations in asthma. | Sandford A | β | 2012 | β |
| Thymic stromal lymphopoietin and allergic disease. | Ziegler SF | β | 2012 | β |
| TSLP: A Key Regulator of Asthma Pathogenesis. | West EE et al. | β | 2012 | β |
| Two single nucleotide polymorphisms in TSLP gene are associated with asthma susceptibility in Chinese Han population. | Liu W et al. | β | 2012 | β |
| Vitamin D and allergic disease: sunlight at the end of the tunnel? | Jones AP et al. | β | 2012 | β |
| Genome-wide association study identifies PERLD1 as asthma candidate gene. | Anantharaman R et al. | β | 2011 | β |
| Polymorphism in Osteopontin Gene (SPP1) Is Associated with Asthma and Related Phenotypes in a Puerto Rican Population. | Arjomandi M et al. | β | 2011 | β |
| Successfully mapping novel asthma loci by GWAS. | Barnes KC | β | 2011 | β |
| The genetics of asthma and allergic disease: a 21st century perspective. | Ober C et al. | β | 2011 | β |