Cocaine use, abuse and dependence in a population-based sample of female twins.
paper
Cited
Public
Unavailable
- Authors
- Kendler, K S; Prescott, C A
- Year
- 1998
- Journal
- The British journal of psychiatry : the journal of mental science
- PMID
- 9926041
- DOI
- 10.1192/bjp.173.4.345
BACKGROUND: Although cocaine use in women has increased substantially over the past half-century, we understand little about the aetiology in women of cocaine use and abuse, and know almost nothing about the role of genetic factors. METHOD: We obtained by telephone interview a history of lifetime cocaine use, abuse and dependence from 1934 individual twins from female-female pairs ascertained through a population-based registry, including both members of 485 monozygotic (MZ) and 335 dizygotic (DZ) pairs. RESULTS: The prevalence of lifetime cocaine use, abuse and dependence were 14.0%, 3.3% and 2.3%. Probandwise concordance rates, in MZ and DZ twins, respectively, were: cocaine use 54% and 42%; cocaine abuse 47% and 8% and cocaine dependence 35% and 0%. In MZ and DZ twins, odds ratios were: cocaine use 14.2 and 6.7 and cocaine abuse 40.8 and 2.7. Biometrical model-fitting suggested that twin resemblance for liability to cocaine use was due to both genetic and familial-environmental factors while twin resemblance for cocaine abuse and symptoms of dependence was due solely to genetic factors. Estimated heritabilities were: cocaine use 0.39, cocaine abuse 0.79 and symptoms of dependence 0.65. CONCLUSIONS: The vulnerability to cocaine use and particularly cocaine abuse and dependence in women is substantially influenced by genetic factors.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Cocaine Use Disorder (CUD): Current Clinical Perspectives. | Schwartz EKC et al. | β | 2022 | β |
| Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications. | Varela RB et al. | β | 2022 | β |
| Identifying alcohol misuse biotypes from neural connectivity markers and concurrent genetic associations. | Zhu T et al. | β | 2022 | β |
| Molecular genetics of cocaine use disorders in humans. | FernΓ ndez-Castillo N et al. | β | 2022 | β |
| Addiction-Associated Genetic Variants Implicate Brain Cell Type- and Region-Specific Cis-Regulatory Elements in Addiction Neurobiology. | Srinivasan C et al. | β | 2021 | β |
| A systems omics-based approach to decode substance use disorders and neuroadaptations. | Veerappa A et al. | β | 2021 | β |
| Extreme Phenotypic Diversity in Operant Responding for an Intravenous Cocaine or Saline Infusion in the Hybrid Mouse Diversity Panel | Bagley JR et al. | β | 2021 | β |
| Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes. | Sherva R et al. | β | 2021 | β |
| Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1β+/-βmice. | Cabana-DomΓnguez J et al. | β | 2021 | β |
| A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and geneβenvironment interaction | Sun J et al. | β | 2020 | β |
| Convergent functional genomics of cocaine misuse in humans and animal models. | Forero DA et al. | β | 2020 | β |
| Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis. | Datta U et al. | β | 2020 | β |
| Role of genetic background in the effects of adolescent nicotine exposure on mesolimbic dopamine transmission. | Cadoni C et al. | β | 2020 | β |
| Environmental, genetic and epigenetic contributions to cocaine addiction. | Pierce RC et al. | β | 2018 | β |
| Neuroepigenetics and addiction. | Walker DM et al. | β | 2018 | β |
| A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence. | Cabana-DomΓnguez J et al. | β | 2016 | β |
| A Review of Genome-Wide Association Studies of Stimulant and Opioid Use Disorders. | Jensen KP | β | 2016 | β |
| Amphetamine self-administration and dopamine function: assessment of geneβΓβenvironment interactions in Lewis and Fischer 344 rats. | Meyer AC et al. | β | 2015 | β |
| Contribution of BDNF and DRD2 genetic polymorphisms to continued opioid use in patients receiving methadone treatment for opioid use disorder: an observational study. | Bawor M et al. | β | 2015 | β |
| Corticosteroid receptor genes and childhood neglect influence susceptibility to crack/cocaine addiction and response to detoxification treatment. | Rovaris DL et al. | β | 2015 | β |
| Substance use in women: Current status and future directions. | Lal R et al. | β | 2015 | β |
| Transcriptomic and genetic studies identify NFAT5 as a candidate gene for cocaine dependence. | FernΓ ndez-Castillo N et al. | β | 2015 | β |
| Comparing the utility of homogeneous subtypes of cocaine use and related behaviors with DSM-IV cocaine dependence as traits for genetic association analysis. | Bi J et al. | β | 2014 | β |
| Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. | Gelernter J et al. | β | 2014 | β |
| The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction. | Clarke TK et al. | β | 2014 | β |
| Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence. | FernΓ ndez-Castillo N et al. | β | 2013 | β |
| Case-control association analysis of polymorphisms in the Ξ΄-opioid receptor, OPRD1, with cocaine and opioid addicted populations. | Crist RC et al. | β | 2013 | β |
| Case-control association study of WLS variants in opioid and cocaine addicted populations. | Crist RC et al. | β | 2013 | β |
| Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis. | Clarke TK et al. | β | 2013 | β |
| Unique genetic factors influence sensitivity to the rewarding and aversive effects of methamphetamine versus cocaine. | Gubner NR et al. | β | 2013 | β |
| Association study of the Ξ²-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population. | Ambrose-Lanci LM et al. | β | 2012 | β |
| Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. | FernΓ ndez-Castillo N et al. | β | 2012 | β |
| Epidemiology of substance use disorders. | Merikangas KR et al. | β | 2012 | β |
| Genome-environmental risk assessment of cocaine dependence. | Wei C et al. | β | 2012 | β |
| Neuronal calcium sensor-1 and cocaine addiction: a genetic association study in African-Americans and European Americans. | Multani PK et al. | β | 2012 | β |
| Shared environmental contributions to substance use. | Baker JH et al. | β | 2012 | β |
| Sulpiride, but not SCH23390, modifies cocaine-induced conditioned place preference and expression of tyrosine hydroxylase and elongation factor 1Ξ± in zebrafish. | Darland T et al. | β | 2012 | β |
| The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. | Derringer J et al. | β | 2012 | β |
| The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency. | Spellicy CJ et al. | β | 2012 | β |
| Linkage analyses of stimulant dependence, craving, and heavy use in American Indians. | Ehlers CL et al. | β | 2011 | β |
| Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence. | Lohoff FW et al. | β | 2010 | β |
| Genetics of drug dependence. | Gelernter J et al. | β | 2010 | β |
| Pharmacogenetics of drug dependence: role of gene variations in susceptibility and treatment. | Khokhar JY et al. | β | 2010 | β |
| Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. | Sherva R et al. | β | 2010 | β |
| Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence. | Uhl GR et al. | β | 2009 | β |
| Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. | Lohoff FW et al. | β | 2009 | β |
| Association analysis between polymorphisms in the dopamine D3 receptor (DRD3) gene and cocaine dependence. | Bloch PJ et al. | β | 2009 | β |
| Genetic association studies of methamphetamine use disorders: A systematic review and synthesis. | Bousman CA et al. | β | 2009 | β |
| New insights into the genetics of addiction. | Li MD et al. | β | 2009 | β |
| Smoking and smoking cessation in disadvantaged women: assessing genetic contributions. | Uhl GR et al. | β | 2009 | β |
| Addiction Reviews. Preface. | Uhl GR | β | 2008 | β |
| Are there genetic influences on addiction: evidence from family, adoption and twin studies. | Agrawal A et al. | β | 2008 | β |
| A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. | Grucza RA et al. | β | 2008 | β |
| Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence. | Lohoff FW et al. | β | 2008 | β |
| Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings. | Bierut LJ et al. | β | 2008 | β |
| Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence. | Lohoff FW et al. | β | 2008 | β |
| "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice. | Uhl GR et al. | β | 2008 | β |
| Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects. | Uhl GR et al. | β | 2008 | β |
| Substance dependence low-density whole genome association study in two distinct American populations. | Yu Y et al. | β | 2008 | β |
| The validity of cocaine dependence subtypes. | Kranzler HR et al. | β | 2008 | β |
| Association analysis of GRK3 gene promoter variants in cocaine abuse. | Guindalini C et al. | β | 2007 | β |
| A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample. | Guindalini C et al. | β | 2006 | β |
| Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence. | Dahl JP et al. | β | 2006 | β |
| Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. | Agrawal A et al. | β | 2006 | β |
| Molecular genetics of addiction vulnerability. | Uhl GR | β | 2006 | β |
| No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence. | Weller AE et al. | β | 2006 | β |
| Pooled association genome scanning for alcohol dependence using 104,268 SNPs: validation and use to identify alcoholism vulnerability loci in unrelated individuals from the collaborative study on the genetics of alcoholism. | Johnson C et al. | β | 2006 | β |
| Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs. | Kalayasiri R et al. | β | 2006 | β |
| Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. | Dahl JP et al. | β | 2005 | β |
| Association study of dopamine D2 and D3 receptor gene polymorphisms with cocaine dependence. | Messas G et al. | β | 2005 | β |
| CASASTART: a community-based, school-centered intervention for high-risk youth. | Murray LF et al. | β | 2005 | β |
| Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence. | Dahl JP et al. | β | 2005 | β |
| Genomewide linkage scan for cocaine dependence and related traits: significant linkages for a cocaine-related trait and cocaine-induced paranoia. | Gelernter J et al. | β | 2005 | β |
| Individual differences in drug dependence in rats: the role of genetic factors and life events. | Ellenbroek BA et al. | β | 2005 | β |
| Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples. | Liu QR et al. | β | 2005 | β |
| The genetics of addictions: uncovering the genes. | Goldman D et al. | β | 2005 | β |
| The X-box binding protein 1 (XBP1) gene is not associated with methamphetamine dependence. | Morita Y et al. | β | 2005 | β |
| Cannabis and other illicit drugs: comorbid use and abuse/dependence in males and females. | Agrawal A et al. | β | 2004 | β |
| Forms of cannabis and cocaine: a twin study. | Agrawal A et al. | β | 2004 | β |
| Molecular genetics of substance abuse vulnerability: remarkable recent convergence of genome scan results. | Uhl GR | β | 2004 | β |
| Molecular genetic underpinnings of human substance abuse vulnerability: likely contributions to understanding addiction as a mnemonic process. | Uhl GR | β | 2004 | β |
| [The role of genetics in alcohol dependence]. | Messas GP et al. | β | 2004 | β |
| Delivering more effective treatment to adolescents: Improving the juvenile drug court model. | Belenko S et al. | β | 2003 | β |
| Genetic variation in the psychomotor stimulant properties of cocaine in Mus musculus. | Downing C et al. | β | 2003 | β |
| Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis. | Ujike H et al. | β | 2003 | β |
| Substance use disorders, externalizing psychopathology, and P300 event-related potential amplitude. | Iacono WG et al. | β | 2003 | β |
| Will the genomics revolution revolutionize psychiatry? | Merikangas KR et al. | β | 2003 | β |
| Substance abuse vulnerability loci: converging genome scanning data. | Uhl GR et al. | β | 2002 | β |
| Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. | Uhl GR et al. | β | 2001 | β |
| Risk factors for adolescent substance abuse. | Weinberg NZ | β | 2001 | β |
| Serotonin transporter (5-HTT) gene polymorphisms and susceptibility to cocaine dependence among African-American individuals. | Patkar AA et al. | β | 2001 | β |
| The relationship between cannabis use and other substance use in the general population. | Degenhardt L et al. | β | 2001 | β |
| Detection of single nucleotide polymorphisms of the human mu opioid receptor gene by hybridization or single nucleotide extension on custom oligonucleotide gelpad microchips: potential in studies of addiction. | LaForge KS et al. | β | 2000 | β |
| Environmental transmission of DSM-IV substance use disdorders in adoptive and step families. | Newlin DB et al. | β | 2000 | β |
| Genetic and environmental influences on adolescent substance use and abuse. | McGue M et al. | β | 2000 | β |
| Implications of genetic epidemiology for the prevention of substance use disorders. | Merikangas KR et al. | β | 2000 | β |
| Multivariate assessment of factors influencing illicit substance use in twins from female-female pairs. | Karkowski LM et al. | β | 2000 | β |
| Opioid receptor and peptide gene polymorphisms: potential implications for addictions. | LaForge KS et al. | β | 2000 | β |
| Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women. | Kendler KS et al. | β | 1999 | β |
| Hallucinogen, opiate, sedative and stimulant use and abuse in a population-based sample of female twins. | Kendler KS et al. | β | 1999 | β |