No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case-control sample.

paper Cited Public

Authors: Nikolov, Momchil A; Beltcheva, Olga; Galabova, Antoaneta; Ljubenova, Anna; Jankova, Elena; Gergov, Galin; Russev, Atanas A; Lynskey, Michael T; Nelson, Elliot C; Nesheva, Eleonora; Krasteva, Dorita; Lazarov, Philip; Mitev, Vanio I; Kremensky, Ivo M; Kaneva, Radka P; Todorov, Alexandre A
Year: 2011
Journal: Drug and alcohol dependence
PMID: 21277709
DOI: 10.1016/j.drugalcdep.2010.12.026
PMCID: PMC3128690

#	Section	Preview
0	1. Introduction	OPRM1 (OMIM: 600018) is a natural candidate gene for studies of opioid dependence (OD) as it encodes…
1	1. Introduction	The possible functional relevance of this polymorphism prompted a number of studies, across several…
2	1. Introduction	linkage disequilibrium with it (Levran et al., 2008). In a meta-analysis of 22 studies including…
3	1. Introduction	However, until a recent Australian study (E.C. Nelson, personal correspondence), most previous work…
4	2. Methods — 2.1. Participants	The sample consists of 1842 active heroin users (1516 ethnic Bulgarian and 326 Roma), the majority…
5	2. Methods — 2.1. Participants	the biobank of the PKU newborn screening program at the National Genetic Laboratory in Sofia…
6	2. Methods — 2.2. Procedures	DNA was extracted from venous blood samples from each heroin dependent subject, and from 10mm…
7	3. Results	Of the 1842 cases, 1528 (83%) were males and 314 (17%) females. Of the 1451 controls, 1142 (79%)…
8	3. Results	The frequency of the G allele in Bulgarian controls did not differ from that reported in other…
9	3. Results	This study was reasonably powered to replicate previous findings. Under the dominant mode of…
10	4. Discussion	This is the first study to examine whether the 118A>G polymorphism in OPRM1 is associated with an…
11	4. Discussion	Women were well represented in this sample (17.3% and 15.6% of ethnic Bulgarian and Roma cases,…
12	4. Discussion	The accumulating findings linking polymorphisms and haplotypes in OPRM1, as well as epigenetic…

Citation	PMID	DOI	Status
Arias, A et al., Drug Alcohol Depend, 2006, Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis	16387451	10.1016/j.drugalcdep.2005.11.024	Cited
Bart, G et al., Neuropsychopharmacology, 2005, Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden	15525999	10.1038/sj.npp.1300598	Cited
Befort, K et al., J. Biol. Chem, 2001, A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling	11067846	10.1074/jbc.M006352200	Cited
Beyer, A et al., J. Neurochem, 2004, Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor	15086512	10.1111/j.1471-4159.2004.02340.x	Cited
Bond, C et al., Proc. Natl. Acad. Sci. U S A, 1998, Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction	9689128	10.1073/pnas.95.16.9608	Cited
Crowley, JJ et al., Psychiatr. Genet, 2003, A genetic association study of the mu opioid receptor and severe opioid dependence	12960749	10.1097/00041444-200309000-00006	Cited
Deb, I et al., J. Neurochem, 2010, Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction	19891732	10.1111/j.1471-4159.2009.06472.x	Cited
Drakenberg, K et al., Proc. Natl. Acad. Sci. U S A, 2006, Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers	16682632	10.1073/pnas.0600871103	Cited
Fillingim, RB et al., J. Pain, 2005, The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans	15772909	10.1016/j.jpain.2004.11.008	Cited
Franke, P et al., Am. J. Med. Genet, 2001, Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence	11424981	—	Cited
Gauderman, WJ et al., 2006, Quanto1.1:A computer program for power and sample size calculations for genetic-epidemiology studies	—	—	—
Glatt, SJ et al., Drug Alcohol Depend, 2007, Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis	17416470	10.1016/j.drugalcdep.2007.02.022	Cited
Gresham, D et al., Am. J. Hum Genet, 2001, Origins and divergence of the Roma (gypsies)	11704928	10.1086/324681	Cited
Hernandez-Avila, CA et al., Am. J. Med. Genet. B Neuropsychiatr. Genet, 2003, Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu-opioid receptor locus (OPRM1)	12627468	10.1002/ajmg.b.10054	Cited
Kapur, S et al., J. Integr. Neurosci, 2007, A118g polymorphism in mu opioid receptor gene (oprm1): association with opiate addiction in subjects of Indian origin	18181266	10.1142/s0219635207001635	Cited
Kim, SG, Nihon Arukoru Yakubutsu Igakkai Zasshi, 2009, Gender differences in the genetic risk for alcohol dependence--the results of a pharmacogenetic study in Korean alcoholics	20077761	—	Cited
Levran, O et al., Genes Brain Behav, 2008, Genetic susceptibility to heroin addiction: a candidate gene association study	18518925	10.1111/j.1601-183X.2008.00410.x	Cited
Mague, SD et al., Proc. Natl. Acad. Sci. USA, 2009, Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior	19528658	10.1073/pnas.0901800106	Cited
Oroszi, G et al., Alcohol Clin. Exp. Res, 2009, OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach	19053977	10.1111/j.1530-0277.2008.00846.x	Cited
Purcell, S et al., Am. J. Hum. Genet, 2007, PLINK: a tool set for whole-genome association and population-based linkage analyses	17701901	10.1086/519795	Cited
Shabalina, SA et al., Hum. Mol. Genet, 2009, Expansion of the human mu-opioid receptor gene architecture: novel functional variants	19103668	10.1093/hmg/ddn439	Cited
Shi, J et al., Hum. Mutat, 2002, Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin	11933204	10.1002/humu.9026	Cited
Szeto, CY et al., Neuroreport, 2001, Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts	11338173	10.1097/00001756-200105080-00011	Cited
Tan, EC et al., Neuroreport, 2003, Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations	12657887	10.1097/00001756-200303240-00008	Cited
Wand, GS et al., Neuropsychopharmacology, 2002, The mu-opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade	11751037	10.1016/S0893-133X(01)00294-9	Cited
Xu, K et al., Arch. Gen. Psychiatry, 2004, Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations	15184239	10.1001/archpsyc.61.6.597	Cited
Yuferov, V et al., Ann. N.Y. Acad. Sci, 2010, Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment	20201854	10.1111/j.1749-6632.2009.05275.x	Cited
Zhang, D et al., Biol. Psychiatry, 2007, Effect of mu-opioid receptor gene polymorphisms on heroin-induced subjective responses in a Chinese population	17157823	10.1016/j.biopsych.2006.07.012	Cited
Zhang, H et al., Hum. Mol. Genet, Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence	16476706	10.1093/hmg/ddl024	Cited
Zhang, L et al., Behav. Brain Funct, The mu-opioid receptor gene and smoking initiation and nicotine dependence	16887046	10.1186/1744-9081-2-28	Cited
Zhang, Y et al., J. Biol. Chem, 2005, Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G	16046395	10.1074/jbc.M504942200	Cited

In this knowledge base

Title	Year	PMID
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.	2016	26392368
Pharmacogenetics of OPRM1.	2014	24201053
The genetics of substance dependence.	2012	22703173

External

Title	Authors	Journal	Year	Link
Haplotype-Based Association and In Silico Studies of OPRM1 Gene Variants with Susceptibility to Opioid Dependence Among Addicted Iranians Undergoing Methadone Treatment.	Tolami HF et al.	—	2020	→
Pharmacogenomics of Pain Management: The Impact of Specific Biological Polymorphisms on Drugs and Metabolism.	Cornett EM et al.	—	2020	→
A review of opioid addiction genetics.	Crist RC et al.	—	2019	→
Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders.	Burns JA et al.	—	2019	→
The association between the OPRM1 A118G polymorphism and addiction in a Turkish population.	Türkan H et al.	—	2019	→
Molecular Genetics and New Medication Strategies for Opioid Addiction.	Hurd YL et al.	—	2018	→
The frequency of <i>DRD2</i> rs1076560 and <i>OPRM1</i> rs1799971 in substance use disorder patients from the United Arab Emirates.	Alblooshi H et al.	—	2018	→
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.	Schwantes-An TH et al.	—	2016	→
T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice.	Wang XF et al.	—	2016	→
Functional mu opioid receptor polymorphism (OPRM1 A(118) G) associated with heroin use outcomes in Caucasian males: A pilot study.	Woodcock EA et al.	—	2015	→
[Stabilization of remission in patients with opioid dependence with naltrexone implant: a pharmacogenetic approach].	Krupitsky ЕМ et al.	—	2015	→
Genetics of opiate addiction.	Reed B et al.	—	2014	→
Pharmacogenetics of OPRM1.	Crist RC et al.	—	2014	→
Genetic variants associated with addictive behavior in Colombian addicted and non-addicted to heroin or cocaine.	Isaza C et al.	—	2013	→
OPRM1 genetic polymorphisms are associated with the plasma nicotine metabolite cotinine concentration in methadone maintenance patients: a cross sectional study.	Chen YT et al.	—	2013	→
OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis.	Haerian BS et al.	—	2013	→
Endogenous opiates and behavior: 2011.	Bodnar RJ	—	2012	→
The genetics of substance dependence.	Wang JC et al.	—	2012	→
Molecular mechanisms of opioid receptor-dependent signaling and behavior.	Al-Hasani R et al.	—	2011	→