A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity.
paper
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- Authors
- Osier, Michael V; Pakstis, Andrew J; Soodyall, Himla; Comas, David; Goldman, David; Odunsi, Adekunle; Okonofua, Friday; Parnas, Josef; Schulz, Leslie O; Bertranpetit, Jaume; Bonne-Tamir, Batsheva; Lu, Ru-Band; Kidd, Judith R; Kidd, Kenneth K
- Year
- 2002
- Journal
- American journal of human genetics
- PMID
- 12050823
- DOI
- 10.1086/341290
- PMCID
- PMC384995
Variants of different Class I alcohol dehydrogenase (ADH) genes have been shown to be associated with an effect that is protective against alcoholism. Previous work from our laboratory has shown that the two sites showing the association are in linkage disequilibrium and has identified the ADH1B Arg47His site as causative, with the ADH1C Ile349Val site showing association only because of the disequilibrium. Here, we describe an initial study of the nature of linkage disequilibrium and genetic variation, in population samples from different regions of the world, in a larger segment of the ADH cluster (including the three Class I ADH genes and ADH7). Linkage disequilibrium across approximately 40 kb of the Class I ADH cluster is moderate to strong in all population samples that we studied. We observed nominally significant pairwise linkage disequilibrium, in some populations, between the ADH7 site and some Class I ADH sites, at moderate values and at a molecular distance as great as 100 kb. Our data indicate (1) that most ADH-alcoholism association studies have failed to consider many sites in the ADH cluster that may harbor etiologically significant alleles and (2) that the relevance of the various ADH sites will be population dependent. Some individual sites in the Class I ADH cluster show Fst values that are among the highest seen among several dozen unlinked sites that were studied in the same subset of populations. The high Fst values can be attributed to the discrepant frequencies of specific alleles in eastern Asia relative to those in other regions of the world. These alleles are part of a single haplotype that exists at high (>65%) frequency only in the eastern-Asian samples. It seems unlikely that this haplotype, which is rare or unobserved in other populations, reached such high frequency because of random genetic drift alone.
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| Not by Selection Alone: Expanding the Scope of Gene-Culture Coevolution. | Kasser SM et al. | β | 2025 | β |
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| Molecular genetics of neuropsychiatric illness: some musings. | Janardhanan M et al. | β | 2023 | β |
| Pharmacokinetic Analysis of Ethanol in a Human Study: New Modification of Mathematic Model. | Zekan P et al. | β | 2023 | β |
| Behavioral consequences of the downstream products of ethanol metabolism involved in alcohol use disorder. | Holbrook OT et al. | β | 2022 | β |
| Ortholog genes from cactophilic Drosophila provide insight into human adaptation to hallucinogenic cacti. | PadrΓ³ J et al. | β | 2022 | β |
| Alcohol intake and the risk of chronic kidney disease: results from a systematic review and dose-response meta-analysis. | Yuan HC et al. | β | 2021 | β |
| A systems omics-based approach to decode substance use disorders and neuroadaptations. | Veerappa A et al. | β | 2021 | β |
| Human Evolution and Dietary Ethanol. | Dudley R et al. | β | 2021 | β |
| No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol. | Shan YS et al. | β | 2021 | β |
| The Molecular Basis of Alcohol Use Disorder (AUD). Genetics, Epigenetics, and Nutrition in AUD: An Amazing Triangle. | Siomek-Gorecka A et al. | β | 2021 | β |
| Whole-Genome Sequencing of a 900-Year-Old Human Skeleton Supports Two Past Migration Events from the Russian Far East to Northern Japan. | Sato T et al. | β | 2021 | β |
| A safe level of alcohol consumption: the right answer demands the right question. | Mukamal KJ | β | 2020 | β |
| Association between rs1229984 in ADH1B and cancer prevalence in a Japanese population. | Govind P et al. | β | 2020 | β |
| Genetic instrumental variable analysis: time to call mendelian randomization what it is. The example of alcohol and cardiovascular disease. | Mukamal KJ et al. | β | 2020 | β |
| The Epistemology of Evolutionary Psychology Offers a Rapprochement to Cultural Psychology. | Saad G | β | 2020 | β |
| Genetic variants of alcohol-metabolizing enzymes in Brugada syndrome: Insights into syncope after drinking alcohol. | Wu Q et al. | β | 2019 | β |
| ADH1B: From alcoholism, natural selection, and cancer to the human phenome. | Polimanti R et al. | β | 2018 | β |
| Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease. | Chang B et al. | β | 2018 | β |
| Associations between alcohol dehydrogenase genes and alcohol use across early and middle adolescence: Moderation Γ Preventive intervention. | Cleveland HH et al. | β | 2018 | β |
| Estimating Time to the Common Ancestor for a Beneficial Allele. | Smith J et al. | β | 2018 | β |
| Recent Selection on a Class I ADH Locus Distinguishes Southwest Asian Populations Including Ashkenazi Jews. | Gu S et al. | β | 2018 | β |
| Alcohol and head and neck cancer. | Kawakita D et al. | β | 2017 | β |
| Alcohol metabolism and oesophageal cancer: a systematic review of the evidence. | Matejcic M et al. | β | 2017 | β |
| Alcohol use and risk of intracerebral hemorrhage. | Chen CJ et al. | β | 2017 | β |
| Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. | Jorgenson E et al. | β | 2017 | β |
| Investigating the Association between Alcohol and Risk of Head and Neck Cancer in Taiwan. | Huang CC et al. | β | 2017 | β |
| The allele frequency of ALDH2*Glu504Lys and ADH1B*Arg47His for the Ryukyu islanders and their history of expansion among East Asians. | Koganebuchi K et al. | β | 2017 | β |
| The fine-scale genetic structure and evolution of the Japanese population. | Takeuchi F et al. | β | 2017 | β |
| ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men. | Yin G et al. | β | 2016 | β |
| Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men. | Wu LS et al. | β | 2016 | β |
| Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism. | Wall TL et al. | β | 2016 | β |
| Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia. | Galinsky KJ et al. | β | 2016 | β |
| Genetic feedback to reduce alcohol consumption in hospital outpatients with risky drinking: feasibility and acceptability. | Johnson NA et al. | β | 2016 | β |
| Mendelian Randomization as an Approach to Assess Causality Using Observational Data. | Sekula P et al. | β | 2016 | β |
| Moderate alcohol drinking in pregnancy increases risk for children's persistent conduct problems: causal effects in a Mendelian randomisation study. | Murray J et al. | β | 2016 | β |
| Alcohol dehydrogenase-1B Arg47His polymorphism is associated with head and neck cancer risk in Asian: a meta-analysis. | Zhang Y et al. | β | 2015 | β |
| Association between ADH1B and ADH1C polymorphisms and the risk of head and neck squamous cell carcinoma. | Ji YB et al. | β | 2015 | β |
| Ethanol, Neurodevelopment, Infant and Child Health (ENRICH) prospective cohort: Study design considerations. | Bakhireva LN et al. | β | 2015 | β |
| Genetic polymorphisms in alcohol dehydrogenase, aldehyde dehydrogenase and alcoholic chronic pancreatitis susceptibility: a meta-analysis. | Zhong Y et al. | β | 2015 | β |
| Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population. | Way M et al. | β | 2015 | β |
| Impact of alcohol dehydrogenase gene 4 polymorphisms on esophageal squamous cell carcinoma risk in a Chinese population. | Xu X et al. | β | 2015 | β |
| Metabolic methanol: molecular pathways and physiological roles. | Dorokhov YL et al. | β | 2015 | β |
| Pharmacogenetic profile of a South Portuguese population: results from the pilot study of the European Health Examination Survey in Portugal. | Gaio V et al. | β | 2015 | β |
| Predicting Carriers of Ongoing Selective Sweeps without Knowledge of the Favored Allele. | Ronen R et al. | β | 2015 | β |
| Alcohol-medical drug interactions. | Johnson BA et al. | β | 2014 | β |
| Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets. | Fagny M et al. | β | 2014 | β |
| Less drinking, yet more problems: understanding African American drinking and related problems. | Zapolski TC et al. | β | 2014 | β |
| Protective effects of the alcohol dehydrogenase-ADH1B*3 allele on attention and behavior problems in adolescents exposed to alcohol during pregnancy. | Dodge NC et al. | β | 2014 | β |
| The interplay between alcohol consumption, oral hygiene, ALDH2 and ADH1B in the risk of head and neck cancer. | Tsai ST et al. | β | 2014 | β |
| Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: a meta-analysis. | Han H et al. | β | 2013 | β |
| Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication. | Park BL et al. | β | 2013 | β |
| Genetics and alcoholism. | Edenberg HJ et al. | β | 2013 | β |
| Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population. | Gao Y et al. | β | 2013 | β |
| Alcohol drinking and overall and cause-specific mortality in China: nationally representative prospective study of 220,000 men with 15 years of follow-up. | Yang L et al. | β | 2012 | β |
| Distinguishing between selective sweeps from standing variation and from a de novo mutation. | Peter BM et al. | β | 2012 | β |
| Fetal alcohol exposure and IQ at age 8: evidence from a population-based birth-cohort study. | Lewis SJ et al. | β | 2012 | β |
| Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. | Frank J et al. | β | 2012 | β |
| Human genomic disease variants: a neutral evolutionary explanation. | Dudley JT et al. | β | 2012 | β |
| The genetics of substance dependence. | Wang JC et al. | β | 2012 | β |
| The role of alcohol dehydrogenase genes in head and neck cancers: a systematic review and meta-analysis of ADH1B and ADH1C. | Chang JS et al. | β | 2012 | β |
| Alcohol-metabolizing enzyme gene polymorphisms in the Basque Country, Morocco, and Ecuador. | Celorrio D et al. | β | 2011 | β |
| An overview of the genetic susceptibility to alcoholism. | Buscemi L et al. | β | 2011 | β |
| Genetic polymorphisms of ADH1C and CYP2E1 and risk of oral squamous cell carcinoma. | Brocic M et al. | β | 2011 | β |
| Genetics of alcohol dependence. | Kimura M et al. | β | 2011 | β |
| Use of genetic markers and gene-diet interactions for interrogating population-level causal influences of diet on health. | Davey Smith G | β | 2011 | β |
| ADH1B*2 allele is protective against alcoholism but not chronic liver disease in the Hungarian population. | Toth R et al. | β | 2010 | β |
| ADH1B*3 and response to alcohol in African-Americans. | McCarthy DM et al. | β | 2010 | β |
| ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis. | Zhang G et al. | β | 2010 | β |
| A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck. | Wei S et al. | β | 2010 | β |
| Genome-wide scans for footprints of natural selection. | Oleksyk TK et al. | β | 2010 | β |
| How culture shaped the human genome: bringing genetics and the human sciences together. | Laland KN et al. | β | 2010 | β |
| Mendelian Randomization for Strengthening Causal Inference in Observational Studies: Application to Gene Γ Environment Interactions. | Smith GD | β | 2010 | β |
| Oral cancer and polymorphism of ethanol metabolising genes. | Marichalar-Mendia X et al. | β | 2010 | β |
| Phylogenetic analysis and selection pressures of 5-HT receptors in human and non-human primates: receptor of an ancient neurotransmitter. | Anbazhagan P et al. | β | 2010 | β |
| A short review on the aetiology and pathophysiology of alcoholism. | Moussas G et al. | β | 2009 | β |
| Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India. | Vaswani M et al. | β | 2009 | β |
| Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. | Macgregor S et al. | β | 2009 | β |
| Distribution of the alcohol dehydrogenase ADH1B*47His allele in Eurasia. | Borinskaya S et al. | β | 2009 | β |
| Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups: The INTERHEART Genetics Study. | Anand SS et al. | β | 2009 | β |
| Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. | Oze I et al. | β | 2009 | β |
| Large allele frequency differences between human continental groups are more likely to have occurred by drift during range expansions than by selection. | Hofer T et al. | β | 2009 | β |
| Mendelian randomization: how it can--and cannot--help confirm causal relations between nutrition and cancer. | Schatzkin A et al. | β | 2009 | β |
| New insights into the genetics of addiction. | Li MD et al. | β | 2009 | β |
| Toxicogenomics and clinical toxicology: an example of the connection between basic and applied sciences. | Ferrer-Dufol A et al. | β | 2009 | β |
| Alcohol consumption: risks and benefits. | Mukamal KJ et al. | β | 2008 | β |
| Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individuals. | Cichoz-Lach H et al. | β | 2008 | β |
| Coding and non-coding polymorphisms in alcohol dehydrogenase alters protein expression and alcohol-associated erythema. | Pershing LK et al. | β | 2008 | β |
| Detecting the Genetic Signature of Natural Selection in Human Populations: Models, Methods, and Data. | Hancock AM et al. | β | 2008 | β |
| Ethnic related selection for an ADH Class I variant within East Asia. | Li H et al. | β | 2008 | β |
| Major genetic components underlying alcoholism in Korean population. | Kim DJ et al. | β | 2008 | β |
| Polymorphism in ADH and MTHFR genes in oral squamous cell carcinoma of Indians. | Solomon PR et al. | β | 2008 | β |
| Abetalipoproteinemia in Israel: evidence for a founder mutation in the Ashkenazi Jewish population and a contiguous gene deletion in an Arab patient. | Benayoun L et al. | β | 2007 | β |
| Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. | Cichoz-Lach H et al. | β | 2007 | β |
| Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study. | Yin G et al. | β | 2007 | β |
| Conservative evolution in duplicated genes of the primate Class I ADH cluster. | Oota H et al. | β | 2007 | β |
| Evidence of positive selection on a class I ADH locus. | Han Y et al. | β | 2007 | β |
| Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia. | Li H et al. | β | 2007 | β |
| Haplotype analysis at the alcohol dehydrogenase gene region in New Zealand MΔori. | Hall DA et al. | β | 2007 | β |
| Health-related effects of genetic variations of alcohol-metabolizing enzymes in African Americans. | Scott DM et al. | β | 2007 | β |
| Human nutrition and genetic variation. | Stover PJ | β | 2007 | β |
| Localizing recent adaptive evolution in the human genome. | Williamson SH et al. | β | 2007 | β |
| Recent and ongoing selection in the human genome. | Nielsen R et al. | β | 2007 | β |
| Single nucleotide polymorphisms in alcohol dehydrogenase genes among some Indian populations. | Rao VR et al. | β | 2007 | β |
| The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. | Edenberg HJ | β | 2007 | β |
| ADH1C*2 allele is associated with alcohol dependence and elevated liver enzymes in Trinidad and Tobago. | Montane-Jaime K et al. | β | 2006 | β |
| Alcohol and cancer. | Boffetta P et al. | β | 2006 | β |
| A map of recent positive selection in the human genome. | Voight BF et al. | β | 2006 | β |
| Association of alcohol-metabolizing genes with alcoholism in a Mexican Indian (Otomi) population. | Montano Loza AJ et al. | β | 2006 | β |
| Associations of variations in alcohol dehydrogenase genes with the level of response to alcohol in non-Asians. | Duranceaux NC et al. | β | 2006 | β |
| Distant HNF1 site as a master control for the human class I alcohol dehydrogenase gene expression. | Su JS et al. | β | 2006 | β |
| Extreme population differences across Neuregulin 1 gene, with implications for association studies. | Gardner M et al. | β | 2006 | β |
| Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. | Prescott CA et al. | β | 2006 | β |
| Interpreting disparate responses to cancer therapy: the role of human population genetics. | Maitland ML et al. | β | 2006 | β |
| Metabolism of trans, trans-muconaldehyde, a cytotoxic metabolite of benzene, in mouse liver by alcohol dehydrogenase Adh1 and aldehyde reductase AKR1A4. | Short DM et al. | β | 2006 | β |
| Nonsynonymous SNPs: validation characteristics, derived allele frequency patterns, and suggestive evidence for natural selection. | Fredman D et al. | β | 2006 | β |
| Nutrition and developmental biology--implications for public health. | Stover PJ et al. | β | 2006 | β |
| SNP selection at the NAT2 locus for an accurate prediction of the acetylation phenotype. | Sabbagh A et al. | β | 2006 | β |
| Applying a new generation of genetic maps to understand human inflammatory disease. | Hafler DA et al. | β | 2005 | β |
| Considerable haplotype diversity within the 23kb encompassing the ADH7 gene. | Han Y et al. | β | 2005 | β |
| Effects of natural selection on interpopulation divergence at polymorphic sites in human protein-coding Loci. | Hughes AL et al. | β | 2005 | β |
| Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action. | Wall TL | β | 2005 | β |
| Genetic associations of alcohol dehydrogenase with alcohol use disorders and endophenotypes in white college students. | Wall TL et al. | β | 2005 | β |
| Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes. | Noso S et al. | β | 2005 | β |
| Genetic time-series analysis identifies a major QTL for in vivo alcohol metabolism not predicted by in vitro studies of structural protein polymorphism at the ADH1B or ADH1C loci. | Birley AJ et al. | β | 2005 | β |
| No alcoholism-protection effects of ADH1B*2 allele in antisocial alcoholics among Han Chinese in Taiwan. | Lu RB et al. | β | 2005 | β |
| p53 polymorphisms in Russia and Belarus: correlation of the 2-1-1 haplotype frequency with longitude. | Khrunin AV et al. | β | 2005 | β |
| Perspectives on human genetic variation from the HapMap Project. | McVean G et al. | β | 2005 | β |
| Polymorphism study of seven SNPs at ADH genes in 15 Chinese populations. | Ma L et al. | β | 2005 | β |
| Race and ethnicity in the genome era: the complexity of the constructs. | Bonham VL et al. | β | 2005 | β |
| Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism. | Choi IG et al. | β | 2005 | β |
| The genetics of addictions: uncovering the genes. | Goldman D et al. | β | 2005 | β |
| Alcohol dehydrogenase 2*3 affects alterations in offspring facial morphology associated with maternal ethanol intake in pregnancy. | Das UG et al. | β | 2004 | β |
| Alcoholism: genes and mechanisms. | Oroszi G et al. | β | 2004 | β |
| Deriving haplotypes through recombination and gene conversion pathways. | el-Mabrouk N | β | 2004 | β |
| [Endophenotype--a new concept for biological characterization of psychiatric disorders]. | Zobel A et al. | β | 2004 | β |
| Genetic modification of the effect of alcohol consumption on CHD. | Hines LM | β | 2004 | β |
| Genetic signatures of strong recent positive selection at the lactase gene. | Bersaglieri T et al. | β | 2004 | β |
| Implications of biogeography of human populations for 'race' and medicine. | Tishkoff SA et al. | β | 2004 | β |
| Possible epistatic role of ADH7 in the protection against alcoholism. | Osier MV et al. | β | 2004 | β |
| Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence. | Huang SY et al. | β | 2004 | β |
| Reduced genetic structure of the Iberian peninsula revealed by Y-chromosome analysis: implications for population demography. | Flores C et al. | β | 2004 | β |
| The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination. | Oota H et al. | β | 2004 | β |
| The future of association studies: gene-based analysis and replication. | Neale BM et al. | β | 2004 | β |
| Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population. | Mulligan CJ et al. | β | 2003 | β |
| Candidate genes for alcohol dependence: a review of genetic evidence from human studies. | Dick DM et al. | β | 2003 | β |
| Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. | Botstein D et al. | β | 2003 | β |
| Global survey of haplotype frequencies and linkage disequilibrium at the RET locus. | Chattopadhyay P et al. | β | 2003 | β |
| Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1. | Risch A et al. | β | 2003 | β |
| 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? | Smith GD et al. | β | 2003 | β |
| Pharmacogenomics of alcohol response and addiction. | Enoch MA | β | 2003 | β |
| Race, ancestry, and genes: implications for defining disease risk. | Kittles RA et al. | β | 2003 | β |
| Structure of linkage disequilibrium in humans: genome factors and population stratification. | Bertranpetit J et al. | β | 2003 | β |
| The application of molecular genetic approaches to the study of human evolution. | Cavalli-Sforza LL et al. | β | 2003 | β |
| Alcohol dehydrogenase and alcohol dependence: variation in genotype-associated risk between populations. | Whitfield JB | β | 2002 | β |
| A proline-threonine substitution in codon 351 of ADH1C is common in Native Americans. | Osier MV et al. | β | 2002 | β |