Effective sample size: Quick estimation of the effect of related samples in genetic case-control association analyses.

paper Cited Public

Authors: Yang, Yaning; Remmers, Elaine F; Ogunwole, Chukwuma B; Kastner, Daniel L; Gregersen, Peter K; Li, Wentian
Year: 2011
Journal: Computational biology and chemistry
PMID: 21333602
DOI: 10.1016/j.compbiolchem.2010.12.006
PMCID: PMC3119257

#	Section	Preview
40	Discussion — The variance inflation factor in the genomic control method	The genomic control method in association studies was proposed in (Devlin and Roeder, 1999; Bacanu…
41	Discussion — The variance inflation factor in the genomic control method	Whether genomic control can correctly capture the population substructures is still under debate…
42	Discussion — The variance inflation factor in the genomic control method	One key debate on genomic control is whether Xgc2 follows a central or non-central chi-square…
43	Discussion — Comparison to the generalized estimation equation approach	The method of generalized estimation equation (GEE), similar to ESS method, has a goal of utilizing…
44	Discussion — Comparison to the generalized estimation equation approach	We use the IFIH1 genotype data in Table 5 to illustrate differences between GEE and ESS. Using the…
45	Discussion — Comparison to the generalized estimation equation approach	The estimation equation is essentially a procedure to determine weights of samples. When samples are…
46	Discussion — Comparison to the generalized estimation equation approach	In conclusion, among alternative approaches in handling correlated samples in genetic association…
47	Methods and Materials — Data sets	A missense SNP rs2476601 in the protein tyrosine phosphatase non-receptor type 22 gene on chromosome…
48	Methods and Materials — Data sets	Another dataset used here is the genotype of a non-synonymous SNP in IFIH1 gene on chromosome 2,…
49	Methods and Materials — Simulations	Simple simulated datasets were created for checking the effective sample size method as applied to…

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