Linking functional decline of telomeres, mitochondria and stem cells during ageing.
paper
Cited
Public
- Authors
- Sahin, Ergün; Depinho, Ronald A
- Year
- 2010
- Journal
- Nature
- PMID
- 20336134
- DOI
- 10.1038/nature08982
- PMCID
- PMC3733214
The study of human genetic disorders and mutant mouse models has provided evidence that genome maintenance mechanisms, DNA damage signalling and metabolic regulation cooperate to drive the ageing process. In particular, age-associated telomere damage, diminution of telomere 'capping' function and associated p53 activation have emerged as prime instigators of a functional decline of tissue stem cells and of mitochondrial dysfunction that adversely affect renewal and bioenergetic support in diverse tissues. Constructing a model of how telomeres, stem cells and mitochondria interact with key molecules governing genome integrity, 'stemness' and metabolism provides a framework for how diverse factors contribute to ageing and age-related disorders.
Haematopoietic stem cells experience functional decline with ageingMajor differences between young (left) and old (right) haematopoietic stem cells (HSCs) are shown, exemplifying general mechanisms that may occur with age in stem cells, including decreased regenerative potential and dysregulated differentiation. Cell-extrinsic and cell-intrinsic factors contribute to the overall functional decline of ageing HSCs. Although the self-renewal capacity might be increased in aged HSCs, there is decreased functional regenerative capacity, particularly under stress conditions. Importantly, aged HSCs have an altered differentiation programme with reduced output of common lymphoid progenitors (CLPs), whereas common myeloid progenitors (CMPs) are produced at the same rate as by young HSCs. The decrease in numbers of CLPs and mature B and T cells (‘immunosenescence’) is in contrast to the increased frequency of common granulocyte–macrophage progenitors (GMPs) and, consequently, granulocytes and macrophages. Numbers of megakaryocyte–erythrocyte progenitors (MEPs) are not altered. Possible cell-extrinsic alterations relevant for HSC function include altered stromal compositions and altered cytokine profiles that favour specific differentiation programmes such as decreased lymphopoiesis and increased myelopoiesis. Other age-related changes could affect osteoblast and endothelial cells that have been shown to modulate HSC function. The relevance of systemic factors in modulating stem-cell function has been shown in parabiosis studies: the regenerative capacity of muscle satellite cells in aged mice was increased by exposure to the circulatory system of young mice through the restoration of Delta–Notch signalling20. LRPs, lineage-restricted progenitors.
LLM interpretation
This diagram compares the functional characteristics and differentiation pathways of young (left) and old (right) haematopoietic stem cells (HSCs). The visualization shows that while common myeloid progenitor (CMP) and megakaryocyte-erythrocyte progenitor (MEP) outputs remain similar, aged HSCs exhibit a reduction in common lymphoid progenitors (CLPs), B cells, and T cells, alongside an increase in granulocyte-macrophage progenitors (GMPs) and their resulting mature cells. The figure also highlights that aged HSCs are influenced by altered systemic factors and microenvironments, leading to decreased regenerative potential.
Telomerase knockout mice with dysfunctional telomeres develop premature ageingTelomerase knockout mice (G1) are viable, with intact chromosomes, and have minor physiological abnormalities in the case of long telomeres (top image; arrow); however, with advanced age, they develop degenerative symptoms sooner than do age-matched mice with wild-type Terc . Continuous interbreeding of telomerase knockout mice leads to subsequent generations of mice (G2, G3 and so on) with telomeres of decreasing length. Mice with dysfunctional telomeres have chromosomal abnormalities (bottom image; arrows point to loss of telomere signal, resulting in fused chromosomes), and they develop multiple ageing-associated degenerative disorders in highly proliferative organs, as well as in post-mitotic tissues. Highly proliferative organs such as the intestine, skin and testes are characterized by atrophic changes indicating stem-cell-based failure. Functional decline in post-mitotic tissues (such as cardiomyopathy) and age-associated metabolic changes (such as insulin resistance) have been noted in mice with dysfunctional telomeres. Such mice have a shortened lifespan and a modest increase in cancer, in line with the role of telomeres in preventing illegitimate recombination events.
LLM interpretation
This figure is a schematic diagram illustrating the progressive effects of telomerase knockout across multiple generations of mice. It combines a pedigree chart showing the breeding of *Terc* or *Tert* mutants with two fluorescence microscopy images of chromosomes, contrasting intact telomeres (top) with telomere loss and end-to-end fusions (bottom). The diagram maps these genetic and chromosomal changes to physiological outcomes, showing that while G1 mice have a near-normal lifespan, subsequent generations (G3–G6) exhibit severe degenerative disorders in post-mitotic tissues and proliferative organs, leading to a markedly decreased lifespan.
A model of interaction between DNA damage, p53 activation and mitochondrial dysfunctionIn this model, genotoxic stress brought about by telomere attrition, impaired DNA repair, ultraviolet (UV) radiation, ionizing radiation (IR), chemicals, ROS and other mechanisms activates p53 and induces cellular growth arrest (in proliferating compartments), senescence or apoptosis. We also propose that p53 can impair mitochondrial function either directly or indirectly (through regulation of ROS-detoxifying enzymes). This p53-mediated mitochondrial dysfunction triggers a cycle of DNA damage, p53 activation, mitochondrial compromise and increased ROS levels leading to additional DNA damage, and so on. The mitochondrial compromise could contribute to organ dysfunction through decreased ATP generation, as well as changes in mitochondrial metabolism. The interplay between p53 and other pathways implicated in ageing is also indicated. Caloric restriction (CR) activates SIRT1, which decreases p53 activity. Also, SIRT1 (and possibly SIRT6) activates PGC-1α and boosts mitochondrial biogenesis2. PGC-1α increases antioxidant defence through upregulation of antioxidants89, whereas p53 has been shown to increase or decrease the expression of antioxidants depending on cellular ROS concentrations86. BMI1 loss has been shown to induce mitochondrial dysfunction directly and induce upregulation of p16/ARF (refs 30, 32). ARF increases p53 activity through interaction with MDM2, the negative regulator of p53.
LLM interpretation
This figure is a schematic diagram illustrating the molecular interactions between DNA damage, p53 activation, and mitochondrial dysfunction. It maps how genotoxic stressors (e.g., UV, IR, telomere dysfunction) activate p53, which in turn leads to gene target activation (apoptosis, senescence) and mitochondrial dysfunction. The model further depicts regulatory loops involving SIRT1/SIRT6, PGC-1$\alpha$, and BMI1, showing how these factors modulate ROS levels and mitochondrial health to ultimately influence tissue function and ageing.
1–20 of 42
Next →
| Name | Type |
|---|---|
| accelerated ageing local | phenotype |
| Accelerated ageing of the immune system local | phenotype |
| accelerated ageing phenotypes local | phenotype |
| accelerated tissue degeneration local | phenotype |
| age | phenotype |
| age-associated disease local | phenotype |
| age-associated physiological decline local | phenotype |
| Age-dependent functional decline of stem cells local | phenotype |
| Aged humans local | cohort |
| Aged human tissues local | cohort |
| aged mice | cohort |
| Aged mouse tissues local | cohort |
| ageing | phenotype |
| Ageing humans local | cohort |
| Ageing mice local | cohort |
| ageing mouse brain local | anatomy |
| ageing phenotype local | phenotype |
| ageing phenotypes local | phenotype |
| ageing_phenotypes local | phenotype |
| Age-related pathologies local | phenotype |
| age-related phenotypes local | phenotype |
| aging | phenotype |
| anaemia | phenotype |
| anaphase bridges local | phenotype |
| antioxidant genes local | gene |
| apoptosis | phenotype |
| apoptotic elimination local | phenotype |
| Arthropathies local | phenotype |
| ataxia telangiectasia local | phenotype |
| ATM | gene |
| ATR local | gene |
| Bmi1 local | gene |
| BMI1 local | gene |
| Bmi1 deficiency local | phenotype |
| bone marrow failure local | phenotype |
| bone_marrow_failure local | phenotype |
| Bone marrow failure local | phenotype |
| bone marrow failure syndromes local | phenotype |
| Bone marrow failure syndromes local | phenotype |
| Bone marrow transplant patients local | cohort |
| brain | anatomy |
| BRCA1 | gene |
| cancer | phenotype |
| CancerIncidence local | phenotype |
| cancer resistance local | phenotype |
| cancer risk | phenotype |
| cardiomyopathy | phenotype |
| cardiovascular disease | phenotype |
| cartilage–hair hypoplasia syndrome local | phenotype |
| CDKN1A local | gene |
| CDKN2A | gene |
| CDKN2AARF local | gene |
| cell-cycle arrest local | phenotype |
| cell proliferation | phenotype |
| cellular senescence | phenotype |
| cellular_senescence local | phenotype |
| centenarians | cohort |
| centenarians' offspring local | cohort |
| chromosomal end-to-end fusions local | phenotype |
| chromosomal fusions local | phenotype |
| chromosomal instability | phenotype |
| cognition | phenotype |
| compromised HSC function local | phenotype |
| compromised NSC renewal local | phenotype |
| Decline in neurogenesis local | phenotype |
| decreased engraftment capacity local | phenotype |
| decreased fecundity local | phenotype |
| decreased HSC activity local | phenotype |
| Decreased lymphoid lineage differentiation local | phenotype |
| decreased mitochondrial function local | phenotype |
| Decreased naive B cell numbers local | phenotype |
| Decreased naive T cell numbers local | phenotype |
| Decreased natural-killer activity local | phenotype |
| Decreased phagocytic ability of neutrophils and macrophages local | phenotype |
| Decrease in functionally competent HSCs local | phenotype |
| degenerative ageing phenotypes local | phenotype |
| Degenerative disease | phenotype |
| DegenerativePhenotype local | phenotype |
| degenerative phenotypes local | phenotype |
| delayed onset of ageing phenotype local | phenotype |
| delayed wound healing local | phenotype |
| dementia | phenotype |
| dentate gyrus | anatomy |
| diminished energy production local | phenotype |
| diminished epithelial replenishment local | phenotype |
| diminished oxidative defence local | phenotype |
| disease progression | phenotype |
| DNA damage | phenotype |
| DNA_damage local | phenotype |
| DNA damage foci local | phenotype |
| DNA damage foci at telomeres local | phenotype |
| Donor age local | phenotype |
| dyskeratosis congenita local | phenotype |
| end-to-end chromosomal fusions local | phenotype |
| engineered mice with hyperactive mutant p53 local | cohort |
| engineered mouse models local | cohort |
| engineered_mouse_models local | cohort |
| Epidermal stem-cell numbers local | phenotype |
| EpithelialCancerBreast local | phenotype |
| EpithelialCancerGI local | phenotype |
| EpithelialCancerSkin local | phenotype |
| epithelial tumours local | phenotype |
| ERCC2 local | gene |
| Expansion of myeloid lineage local | phenotype |
| FANCD1 local | gene |
| Fancd1_knockout_mice local | cohort |
| feeble immune responses local | phenotype |
| Fibroblasts local | drug |
| FoxO | gene |
| frailty | phenotype |
| functional decline local | phenotype |
| functional impairment | phenotype |
| G1 Terc−/− mice local | cohort |
| G3+ Terc−/− mice local | cohort |
| Genotoxic stress local | phenotype |
| germline p53 hyperactivation mice local | cohort |
| glucocorticoid | drug |
| glucose intolerance | phenotype |
| granular layer | anatomy |
| hair greying local | phenotype |
| Hair growth local | phenotype |
| hair loss local | phenotype |
| Hayflick limit local | phenotype |
| healthy | phenotype |
| HSC failure local | phenotype |
| HSC–NSC depletion phenotype local | phenotype |
| human | cohort |
| hyperactive mutant p53 allele local | variant |
| hyperactive mutant TP53 local | variant |
| hyper-p53 mice local | cohort |
| hyper‑p53 mice local | cohort |
| Hyperproliferative HSC phenotype local | phenotype |
| hypoxia | phenotype |
| idiopathic pulmonary fibrosis | phenotype |
| impaired differentiation local | phenotype |
| impaired haematopoiesis local | phenotype |
| impaired organ function local | phenotype |
| Impaired regeneration after injury local | phenotype |
| impaired wound healing local | phenotype |
| increased apoptosis local | phenotype |
| increased_apoptosis local | phenotype |
| Increased memory B cell numbers local | phenotype |
| Increased memory T cell numbers local | phenotype |
| Ink4a/Arf deficiency local | phenotype |
| Ink4a/Arf−/− mice local | cohort |
| Ink4aArfMinusMinus_Mice local | cohort |
| intestinal atrophy local | phenotype |
| ionizing_radiation local | drug |
| kyphosis local | phenotype |
| laboratory mice null for Terc local | cohort |
| laboratory mice null for Tert local | cohort |
| late-generation Terc−/− Ink4a/Arf−/− mice local | cohort |
| Late-generation Terc−/− Ink4a/Arf−/− mice local | cohort |
| late-generation Terc−/− mice local | cohort |
| Late-generation Terc−/− p53−/− mice local | cohort |
| LateGen_TercMinusMinus_Ink4aArfMinusMinus_Mice local | cohort |
| LateGen_TercMinusMinus_p53MinusMinus_Mice local | cohort |
| LateGen_TercMinusMinus_p53PlusPlus_Mice local | cohort |
| life expectancy | phenotype |
| lifespan | phenotype |
| life-threatening infections local | phenotype |
| LIG4 local | gene |
| lipid profiles local | phenotype |
| Liver cirrhosis | phenotype |
| longer latency local | phenotype |
| longevity | phenotype |
| loss of oxidative defence local | phenotype |
| lymphoma local | phenotype |
| Lymphoma local | phenotype |
| lymphopenia local | phenotype |
| malignancy local | phenotype |
| MDM2 local | gene |
| melanocyte_stem_cell_attrition local | phenotype |
| mice | cohort |
| mild glucose intolerance local | phenotype |
| mismatch repair defects | phenotype |
| Mitochondrial complex I local | drug |
| Mitochondrial complex III local | drug |
| mitochondrial DNA mutation mice local | cohort |
| mitochondrial DNA mutations local | phenotype |
| mitochondrial dysfunction | phenotype |
| Mobilization capacity local | phenotype |
| mortality rates local | phenotype |
| MSH2 | gene |
| Msh2_knockout_mice local | cohort |
| mTOR | gene |
| muscle atrophy local | phenotype |
| myeloid lineage differentiation local | phenotype |
| neuro-degeneration local | phenotype |
| neurogenesis decline local | phenotype |
| Normocytic anaemia local | phenotype |
| NSC quiescence local | phenotype |
| nucleotide excision repair defects local | phenotype |
| Old mice local | cohort |
| old mouse brain local | anatomy |
| olfactory bulb | anatomy |
| olfactory discrimination impairment local | phenotype |
| olfactory epithelium | anatomy |
| Oncogene activation local | phenotype |
| organ atrophy local | phenotype |
| organismal ageing local | phenotype |
| osteoporosis | phenotype |
| OverallLongevity local | phenotype |
| oxidative stress | phenotype |
| p16Ink4a | gene |
| p19ARF local | gene |
| p53-dependent apoptosis local | phenotype |
| Parabiotic mice local | cohort |
| PGC-1α deficient mice local | cohort |
| PGC-1β deficient mice local | cohort |
| phenotypically unaffected local | phenotype |
| PI3K | gene |
| POLG local | gene |
| PPARGC1A | gene |
| PPARGC1B | gene |
| Preferred differentiation towards myeloid lineages local | phenotype |
| premature ageing local | phenotype |
| premature ageing phenotypes local | phenotype |
| progeroid syndromes local | phenotype |
| Pro-inflammatory state local | phenotype |
| proliferative arrest local | phenotype |
| pro-oxidant genes local | gene |
| psychiatric disorders | phenotype |
| Psychological stress local | phenotype |
| PTEN | gene |
| Pulmonary disease | phenotype |
| RAD50 local | gene |
| RAD50_hypermorphic_allele local | variant |
| Rad50_hypermorphic_mice local | cohort |
| rapamycin | drug |
| reactive oxygen species | drug |
| reduced_life_expectancy local | phenotype |
| reduced NSC pool local | phenotype |
| Regenerative potential decline local | phenotype |
| replicative potential local | phenotype |
| Repopulation capacity local | phenotype |
| repopulation capacity impairment local | phenotype |
| RMRP local | gene |
| RNase MRP complex local | drug |
| ROS | drug |
| ROS-induced stem-cell depletion local | phenotype |
| Rostral migratory stream local | anatomy |
| RPS6KB1 local | gene |
| sarcoma local | phenotype |
| Sarcoma local | phenotype |
| Satellite cell differentiation capacity decrease local | phenotype |
| Satellite cell number decrease local | phenotype |
| Satellite cell proliferative capacity decrease local | phenotype |
| senescent cells local | phenotype |
| Senescent sequelae local | phenotype |
| shortened telomeres local | phenotype |
| short limiting telomeres local | phenotype |
| short telomeres local | phenotype |
| SIRT1 | gene |
| SIRT6 local | gene |
| Sirt6_deletion_mice local | cohort |
| Skin renewal local | phenotype |
| stem_cell_attrition local | phenotype |
| stem-cell compromise local | phenotype |
| stem-cell decline local | phenotype |
| stem_cell_decline local | phenotype |
| stem‑cell defects local | phenotype |
| stem cell depletion local | phenotype |
| Stem-cell depletion phenotype local | phenotype |
| StemCellFunction local | phenotype |
| stem-cell loss local | phenotype |
| stroke | phenotype |
| Subgranular zone | anatomy |
| subventricular zone | anatomy |
| telomerase local | drug |
| Telomerase local | drug |
| Telomerase activity local | drug |
| telomerase knockout mice local | cohort |
| telomerase knockout mouse local | cohort |
| telomere capping status local | phenotype |
| Telomere damage and erosion local | phenotype |
| telomere dysfunction local | phenotype |
| telomere_dysfunction local | phenotype |
| Telomere dysfunction local | phenotype |
| telomere-dysfunctional mice local | cohort |
| telomere erosion local | phenotype |
| telomere length | phenotype |
| Telomere length maintenance defects local | phenotype |
| telomere_maintenance local | phenotype |
| telomere reserves local | phenotype |
| Telomeres | drug |
| telomere shortening local | phenotype |
| Terc local | gene |
| TERC local | gene |
| TERC−/− mice local | cohort |
| Terc−/− mouse model local | cohort |
| TERT | gene |
| testicular atrophy local | phenotype |
| tissue atrophy local | phenotype |
| tissue degeneration local | phenotype |
| tissue stem-cell defects local | phenotype |
| Tissue stem cell depletion local | phenotype |
| TP53 | gene |
| TP53 deficiency local | variant |
| transgenic mice | cohort |
| Transplant recipient survival local | phenotype |
| Trp53 | gene |
| TSC1 local | gene |
| TumourSpectrum local | phenotype |
| type 2 diabetes | phenotype |
| Werner syndrome local | phenotype |
| wild-type mice | cohort |
| wild‑type TP53 extra‑copy mice local | cohort |
| Wound healing | phenotype |
| WRN local | gene |
| XRCC5 | gene |
| XRCC6 | gene |
| years of healthy life local | phenotype |
| young mice | cohort |
| young mouse brain local | anatomy |
| ZMPSTE24 local | gene |
No uploaded files.
Not in any collection.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Detectable clonal mosaicism and its relationship to aging and cancer. | 2012 | 22561519 |
| Detectable clonal mosaicism from birth to old age and its relationship to cancer. | 2012 | 22561516 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A Novel Human Cellular System for Studying Normal Aging and for Anti-Aging Discovery. | Feng Z et al. | — | 2026 | → |
| DMTF1 up-regulation rescues proliferation defect of telomere dysfunctional neural stem cells via the SWI/SNF-E2F axis. | Liang Y et al. | — | 2026 | → |
| Telomerase Knockout in Myeloid Cells Predisposes Mice to Foam Cell Formation, Dyslipidemia, Lung Fibrosis, and Cardiac Dysfunction. | Gao Z et al. | — | 2026 | → |
| A novel carnivorous diet reduces brain telomere length. | Shephard AM et al. | — | 2025 | → |
| A Photophosphorylation Nanobot for Restoring Anabolism of Myocardial Injury. | Li Y et al. | — | 2025 | → |
| Biodentine Counteracts the Aging Process of Human Dental Pulp Stem Cells Through Wnt/β-Catenin Pathway. | Zhang Q et al. | — | 2025 | → |
| Bioenergetic-active hydrogel drives extracellular matrix synthesis for cartilage repair. | Jiang S et al. | — | 2025 | → |
| Caloric Restriction and Telomere Preservation in TERT Knockout Adipocyte Progenitors Does Not Rescue Mice From Metabolic Dysfunction due to a TERT Function in Adipocyte Mitochondria. | Gao Z et al. | — | 2025 | → |
| Causal association between dietary factors and telomere length revealed by mendelian randomization. | Yue X et al. | — | 2025 | → |
| Causal associations of frailty and type 2 diabetes mellitus: A bidirectional Mendelian randomization study. | Gao Y et al. | — | 2025 | → |
| Extended longevity of termite kings and queens is accompanied by extranuclear localization of telomerase in somatic organs and caste-specific expression of its isoforms. | Pangrácová M et al. | — | 2025 | → |
| Leukocyte telomere attrition in cognitive decline: associations with APOE genotype and cardiovascular risk factors. | Barros AGA et al. | — | 2025 | → |
| Light-Driven Artificial Cell Micromotors for Degenerative Knee Osteoarthritis. | Gao C et al. | — | 2025 | → |
| Long-term exposure to ambient PM<sub>1</sub> accelerates biological aging in middle-aged and older adults in China. | Ke J et al. | — | 2025 | → |
| Pharmacological interventions and telomere length in patients with schizophrenia and bipolar disorder: A systematic review and meta-analysis. | Sánchez-González JL et al. | — | 2025 | → |
| Postoperative Adverse Outcomes in Patients With Frailty Undergoing Urologic Surgery Among American Patients: A Propensity-Score Matched Retrospective Cohort Study. | Hsu CW et al. | — | 2025 | → |
| Senescence caused by telomerase inactivation in myeloid, mesenchymal, and endothelial cells has distinct effects on cancer progression. | Rupert J et al. | — | 2025 | → |
| Stratification of telomerase activity in cancer reveals associations with senescence and genomic instability. | Noureen N et al. | — | 2025 | → |
| Sympathetic-parasympathetic system deregulation theory of aging. | Errico JP et al. | — | 2025 | → |
| Telomerase reverse transcriptase gene knock-in unleashes enhanced longevity and accelerated damage repair in mice. | Zhu TY et al. | — | 2025 | → |
| The dynamic relationship of brain-derived neurotrophic factor and oxytocin: Introducing the concept of neurosocial plasticity. | Faraji J et al. | — | 2025 | → |
| The prevalence and risk of mortality associated with antimicrobial resistance within nosocomial settings-a global systematic review and meta-analysis of over 20,000 patients. | George NA et al. | — | 2025 | → |
| Transcriptomic Differences Related to Neck Pain in Patients with Oropharyngeal Squamous Cell Carcinoma. | Wagner MA et al. | — | 2025 | → |
| Unexpected links between cancer and telomere state. | Lanna A | — | 2025 | → |
| Aging and atrial fibrillation: A vicious circle. | Gao P et al. | — | 2024 | → |
| Aging, Cancer, and Inflammation: The Telomerase Connection. | Boccardi V et al. | — | 2024 | → |
| A Mesenchymal stem cell Aging Framework, from Mechanisms to Strategies. | Zhao H et al. | — | 2024 | → |
| A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study. | de Jaeger C et al. | — | 2024 | → |
| Bioenergetic-active exosomes for cartilage regeneration and homeostasis maintenance. | Liu X et al. | — | 2024 | → |
| Cellular senescence and its pathogenic and therapeutic implications in autoimmune hepatitis. | Czaja AJ | — | 2024 | → |
| Changes in <i>TP53</i> Gene, Telomere Length, and Mitochondrial DNA in Benign Prostatic Hyperplasia Patients. | Zole E et al. | — | 2024 | → |
| Electroacupuncture pretreatment preserves telomerase reverse transcriptase function and alleviates postoperative cognitive dysfunction by suppressing oxidative stress and neuroinflammation in aged mice. | Wang W et al. | — | 2024 | → |
| Endogenous sulfur dioxide deficiency as a driver of cardiomyocyte senescence through abolishing sulphenylation of STAT3 at cysteine 259. | Zhang S et al. | — | 2024 | → |
| Endothelial-specific telomerase inactivation causes telomere-independent cell senescence and multi-organ dysfunction characteristic of aging. | Gao Z et al. | — | 2024 | → |
| Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle. | Zhuang Y et al. | — | 2024 | → |
| Extended longevity of termite kings and queens is accompanied by extranuclear localization of telomerase in somatic organs and caste-specific expression of its isoforms | Pangrácová M et al. | — | 2024 | — |
| Food-derived Peptides as Promising Neuroprotective Agents: Mechanism and Therapeutic Potential. | Patel K et al. | — | 2024 | → |
| Human Cord Blood Endothelial Progenitor Cells and Pregnancy Complications (Preeclampsia, Gestational Diabetes Mellitus, and Fetal Growth Restriction). | Kwon JY et al. | — | 2024 | → |
| Interactions between mitochondrial dysfunction and other hallmarks of aging: Paving a path toward interventions that promote healthy old age. | Li Y et al. | — | 2024 | → |
| Investigating the association between blood metabolites and telomere length: A mendelian randomization study. | Gao C | — | 2024 | → |
| Lack of telomerase reduces cancer incidence and increases lifespan of zebrafish tp53<sup>M214K</sup> mutants. | Şerifoğlu N et al. | — | 2024 | → |
| LINE-1-Induced Retrotransposition Affects Early Preimplantation Embryo DNA Integrity and Pluripotency. | Sakaloglou P et al. | — | 2024 | → |
| Mechanisms and metabolic consequences of adipocyte progenitor replicative senescence. | Lin T et al. | — | 2024 | → |
| Nature-Inspired Thylakoid-Based Photosynthetic Nanoarchitectures for Biomedical Applications. | Kong Q et al. | — | 2024 | → |
| Neuronal Stem Cells from Late-Onset Alzheimer Patients Show Altered Regulation of Sirtuin 1 Depending on Apolipoprotein E Indicating Disturbed Stem Cell Plasticity. | Jung M et al. | — | 2024 | → |
| Prenatal air pollution exposure in relation to the telomere-mitochondrial axis of aging at birth: A systematic review. | Mishra S et al. | — | 2024 | → |
| Reprogramming hematopoietic stem cell metabolism in lung cancer: glycolysis, oxidative phosphorylation, and the role of 2-DG. | Guo Z et al. | — | 2024 | → |
| Telomerase RNA component knockout exacerbates <i>Staphylococcus aureus</i> pneumonia by extensive inflammation and dysfunction of T cells. | Reisser Y et al. | — | 2024 | → |
| TERT activation targets DNA methylation and multiple aging hallmarks. | Shim HS et al. | — | 2024 | → |
| The association between dietary selenium intake and telomere length in hypertension. | Liang C et al. | — | 2024 | → |
| The association of circulating systemic inflammation with premature death and the protective role of the Mediterranean diet: a large prospective cohort study of UK biobank. | Liu S et al. | — | 2024 | → |
| The relationship between mitochondrial health, telomerase activity and longitudinal telomere attrition, considering the role of chronic stress. | Guillen-Parra M et al. | — | 2024 | → |
| Unlocking longevity: the role of telomeres and its targeting interventions. | Schellnegger M et al. | — | 2024 | → |
| A Narrative Review of Telomere Length Modulation Through Diverse Yoga and Meditation Styles: Current Insights and Prospective Avenues. | Aghajanyan V et al. | — | 2023 | → |
| Association of physical activity and nutrition with telomere length, a marker of cellular aging: A comprehensive review. | Güneşliol BE et al. | — | 2023 | → |
| Associations of genetically predicted circulating levels of cytokines with telomere length: a Mendelian randomization study. | Pan R et al. | — | 2023 | → |
| Exploring the molecular mechanism underlying the psoriasis and T2D by using microarray data analysis. | Yang L et al. | — | 2023 | → |
| Gene expression in mice with endothelium-specific telomerase knockout. | Gao Z et al. | — | 2023 | → |
| Genomic approaches to mitigating genetic diversity loss in declining populations. | Bossu CM et al. | — | 2023 | → |
| GLP1 Receptor Agonists-Effects beyond Obesity and Diabetes. | Wilbon SS et al. | — | 2023 | → |
| How can early life adversity still exert an effect decades later? A question of timing, tissues and mechanisms. | Mposhi A et al. | — | 2023 | → |
| Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems. | Girotra M et al. | — | 2023 | → |
| Instant Coffee Is Negatively Associated with Telomere Length: Finding from Observational and Mendelian Randomization Analyses of UK Biobank. | Wei Y et al. | — | 2023 | → |
| Investigating the impact of metabolic syndrome traits on telomere length: a Mendelian randomization study. | Loh NY et al. | — | 2023 | → |
| Overexpression of adrenomedullin (ADM) alleviates the senescence of human dental pulp stem cells by regulating the miR-152/CCNA2 pathway. | Dou W et al. | — | 2023 | → |
| POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis. | Nakashima K et al. | — | 2023 | → |
| Prion infection modulates hematopoietic stem/progenitor cell fate through cell-autonomous and non-autonomous mechanisms. | Sim HJ et al. | — | 2023 | → |
| Tendon Aging. | Graça AL et al. | — | 2023 | → |
| Transcriptomic Signature of the Simulated Microgravity Response in <i>Caenorhabditis elegans</i> and Comparison to Spaceflight Experiments. | Çelen İ et al. | — | 2023 | → |
| TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs. | Eguchi A et al. | — | 2023 | → |
| A multi-exposure approach to study telomere dynamics in childhood: A role for residential green space and waist circumference. | De Ruyter T et al. | — | 2022 | → |
| A plant-derived natural photosynthetic system for improving cell anabolism. | Chen P et al. | — | 2022 | → |
| Association between the peripartum maternal and fetal telomere lengths and mitochondrial DNA copy numbers and preeclampsia: a prospective case-control study. | Zhang R et al. | — | 2022 | → |
| BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice. | Li L et al. | — | 2022 | → |
| Cancer-related accelerated ageing and biobehavioural modifiers: a framework for research and clinical care. | Carroll JE et al. | — | 2022 | → |
| Cellular senescence signaling in cancer: A novel therapeutic target to combat human malignancies. | Fakhri S et al. | — | 2022 | → |
| Dying with Cancer and COVID-19, with Special Reference to Lung Cancer: Frailty as a Risk Factor. | Strang P et al. | — | 2022 | → |
| [Effects and mechanism of hydrogen peroxide pretreatment with low molarity on oxidative stress induced apoptosis of mouse bone marrow mesenchymal stem cells]. | Zhang S et al. | — | 2022 | → |
| Emergency readmissions following geriatric ground-level falls: How does frailty factor in? | Hosseinpour H et al. | — | 2022 | → |
| Focus on the Contribution of Oxidative Stress in Skin Aging. | Papaccio F et al. | — | 2022 | → |
| [Gerontological aspects of eye diseases]. | Yusef YN et al. | — | 2022 | → |
| Hot and dry conditions predict shorter nestling telomeres in an endangered songbird: Implications for population persistence. | Eastwood JR et al. | — | 2022 | → |
| Interrelationships and determinants of aging biomarkers in cord blood. | Reimann B et al. | — | 2022 | → |
| Is heart failure with preserved ejection fraction a 'dementia' of the heart? | Tini G et al. | — | 2022 | → |
| NPGREAT: assembly of human subtelomere regions with the use of ultralong nanopore reads and linked-reads. | Adam E et al. | — | 2022 | → |
| Recent updates on the biological basis of heterogeneity in bone marrow stromal cells/skeletal stem cells. | Arora D et al. | — | 2022 | → |
| Relationship between DNA damage measured by the comet-assay and cognitive function. | Lorenzo-López L et al. | — | 2022 | → |
| Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins. | Tabibzadeh S | — | 2022 | → |
| Role of angiotensin II in aging. | Yi W et al. | — | 2022 | → |
| Telomere length positively correlates with pace-of-life in a sex- and cohort-specific way and elongates with age in a wild mammal. | Tissier ML et al. | — | 2022 | → |
| Telomere Length, SIRT1, and Insulin in Male Master Athletes: The Path to Healthy Longevity? | Aguiar SS et al. | — | 2022 | → |
| Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging. | Lyu Y et al. | — | 2022 | → |
| Ageing, Age-Related Cardiovascular Risk and the Beneficial Role of Natural Components Intake. | Rysz J et al. | — | 2021 | → |
| Aging, Social Distancing, and COVID-19 Risk: Who is more Vulnerable and Why? | Faraji J et al. | — | 2021 | → |
| Anti-senescent drug screening by deep learning-based morphology senescence scoring. | Kusumoto D et al. | — | 2021 | → |
| A quantitative yeast aging proteomics analysis reveals novel aging regulators. | Sun Y et al. | — | 2021 | → |
| Associations Between Serum GDF15 Concentrations, Muscle Mass, and Strength Show Sex-Specific Differences in Older Hospital Patients. | Herpich C et al. | — | 2021 | → |
| Automated Optical Tweezers Manipulation to Transfer Mitochondria from Fetal to Adult MSCs to Improve Antiaging Gene Expressions. | Shakoor A et al. | — | 2021 | → |
| Bradykinin Protects Human Endothelial Progenitor Cells from High-Glucose-Induced Senescence through B2 Receptor-Mediated Activation of the Akt/eNOS Signalling Pathway. | Wu Y et al. | — | 2021 | → |
| Cellular senescence in cancer: from mechanisms to detection. | Ou HL et al. | — | 2021 | → |
| Decoding and rejuvenating human ageing genomes: Lessons from mosaic chromosomal alterations. | Dai X et al. | — | 2021 | → |
| Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis. | Spiecker L et al. | — | 2021 | → |
| Dynamics of leukocyte telomere length in adults aged 50 and older: a longitudinal population-based cohort study. | Huang Z et al. | — | 2021 | → |
| Early stem cell aging in the mature brain. | Ibrayeva A et al. | — | 2021 | → |
| Fructose Causes Liver Damage, Polyploidy, and Dysplasia in the Setting of Short Telomeres and p53 Loss. | Chronowski C et al. | — | 2021 | → |
| Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway. | Zhang S et al. | — | 2021 | → |
| Premature aging disorders: A clinical and genetic compendium. | Schnabel F et al. | — | 2021 | → |
| Respiratory viral infections in the elderly. | Watson A et al. | — | 2021 | → |
| Resveratrol prevents steroid-induced osteonecrosis of the femoral head via miR-146a modulation. | Nan K et al. | — | 2021 | → |
| Telomerase as a Therapeutic Target in Cardiovascular Disease. | Hoffmann J et al. | — | 2021 | → |
| Telomere dysfunction instigates inflammation in inflammatory bowel disease. | Chakravarti D et al. | — | 2021 | → |
| Telomere length and metabolic syndrome traits: A Mendelian randomisation study. | Loh NY et al. | — | 2021 | → |
| The Phosphorylated Form of the Histone H2AX (γH2AX) in the Brain from Embryonic Life to Old Age. | Merighi A et al. | — | 2021 | → |
| The PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders. | Teng Y et al. | — | 2021 | → |
| Tissue-specific telomere shortening and degenerative changes in a patient with <i>TINF2</i> mutation and dyskeratosis congenita. | Roake CM et al. | — | 2021 | → |
| Urinary arsenic and relative telomere length in 5-7 year old children in Bangladesh. | Farzan SF et al. | — | 2021 | → |
| Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease. | Gao Z et al. | — | 2020 | → |
| Age‑related changes in mineralocorticoid receptors in rat hearts. | Hu D et al. | — | 2020 | → |
| A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia. | Piers TM et al. | — | 2020 | → |
| Analytical Validation of Telomere Analysis Technology® for the High-Throughput Analysis of Multiple Telomere-Associated Variables. | de Pedro N et al. | — | 2020 | → |
| Assessments of frailty in bladder cancer. | Grimberg DC et al. | — | 2020 | → |
| Association between socioeconomic markers and adult telomere length differs according to sex: Pro-Saúde study. | Normando P et al. | — | 2020 | → |
| Cardiomyocyte ageing and cardioprotection: consensus document from the ESC working groups cell biology of the heart and myocardial function. | Ruiz-Meana M et al. | — | 2020 | → |
| Cellular Senescence as the Pathogenic Hub of Diabetes-Related Wound Chronicity. | Berlanga-Acosta JA et al. | — | 2020 | → |
| Changes of Wnt/β-catenin signalling, BMP2, and BMP4 in the jejunum during ageing in rats. | Dun Y et al. | — | 2020 | → |
| Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans. | Wong TH et al. | — | 2020 | → |
| Developmental programming of mitochondrial biology: a conceptual framework and review. | Gyllenhammer LE et al. | — | 2020 | → |
| Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges. | Zhou X et al. | — | 2020 | → |
| Premature cell senescence in human skin: Dual face in chronic acquired pigmentary disorders. | Bellei B et al. | — | 2020 | → |
| Rare Ginsenoside 20(R)-Rg3 Inhibits D-Galactose-Induced Liver and Kidney Injury by Regulating Oxidative Stress-Induced Apoptosis. | Li W et al. | — | 2020 | → |
| Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies. | Liu J et al. | — | 2020 | → |
| Stem Cells of the Aging Brain. | Nicaise AM et al. | — | 2020 | → |
| Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance. | Anestopoulos I et al. | — | 2020 | → |
| TERT promoter alterations could provide a solution for Peto's paradox in rodents. | Vedelek B et al. | — | 2020 | → |
| The Crosstalk of Adipose-Derived Stem Cells (ADSC), Oxidative Stress, and Inflammation in Protective and Adaptive Responses. | Rochette L et al. | — | 2020 | → |
| The Potential Mechanisms of the Neuroprotective Actions of Oil Palm Phenolics: Implications for Neurodegenerative Diseases. | Ibrahim N' et al. | — | 2020 | → |
| Updated Understanding of Cancer as a Metabolic and Telomere-Driven Disease, and Proposal for Complex Personalized Treatment, a Hypothesis. | Muresanu C et al. | — | 2020 | → |
| Variants in gene encoding for vitamin D binding protein were associated with leukocyte telomere length: The Pró-Saúde Study. | Normando P et al. | — | 2020 | → |
| Accelerated aging in serious mental disorders. | Bersani FS et al. | — | 2019 | → |
| A curated gene list for expanding the horizons of pigmentation biology. | Baxter LL et al. | — | 2019 | → |
| Age-related dysfunction of the DNA damage response in intestinal stem cells. | Watanabe K et al. | — | 2019 | → |
| Aging and Mechanoadaptive Responsiveness of Bone. | Javaheri B et al. | — | 2019 | → |
| Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype? | Saenen ND et al. | — | 2019 | → |
| Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models. | Kuk MU et al. | — | 2019 | → |
| Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice. | Liu XY et al. | — | 2019 | → |
| Applying hydrodynamic pressure to efficiently generate induced pluripotent stem cells via reprogramming of centenarian skin fibroblasts. | Vosough M et al. | — | 2019 | → |
| [Effects of resveratrol on aging of mesenchymal stem cells and its mechanism]. | Zhang D et al. | — | 2019 | → |
| Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retina. | Wang N et al. | — | 2019 | → |
| Expression of Clusterin suppresses Cr(VI)-induced premature senescence through activation of PI3K/AKT pathway. | Zhang Y et al. | — | 2019 | → |
| Genetic and epigenetic regulation of human aging and longevity. | Morris BJ et al. | — | 2019 | → |
| Geriatric Physiology and the Frailty Syndrome. | Khan KT et al. | — | 2019 | → |
| Harnessing CD8<sup>+</sup> T Cells Under HIV Antiretroviral Therapy. | Warren JA et al. | — | 2019 | → |
| Heterogeneity of Stem Cells in the Hippocampus. | Tosun M et al. | — | 2019 | → |
| Inflamm-aging of hematopoietic stem cells. | Chen Z et al. | — | 2019 | → |
| Leukocyte telomere length and serum polyunsaturated fatty acids, dietary habits, cardiovascular risk factors and features of myocardial infarction in elderly patients. | Kalstad AA et al. | — | 2019 | → |
| Plant-derived mitochondria-targeting cysteine-rich peptide modulates cellular bioenergetics. | Kam A et al. | — | 2019 | → |
| Relationship between senescence in macaques and bone marrow mesenchymal stem cells and the molecular mechanism. | Pan XH et al. | — | 2019 | → |
| Remyelination Pharmacotherapy Investigations Highlight Diverse Mechanisms Underlying Multiple Sclerosis Progression. | Melchor GS et al. | — | 2019 | → |
| Stem cells: past, present, and future. | Zakrzewski W et al. | — | 2019 | → |
| Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. | Amano H et al. | — | 2019 | → |
| Telomere Gene Therapy: Polarizing Therapeutic Goals for Treatment of Various Diseases. | Hong J et al. | — | 2019 | → |
| Telomere length and frailty in older adults-A systematic review and meta-analysis. | Araújo Carvalho AC et al. | — | 2019 | → |
| The relation of telomere length at midlife to subsequent 20-year depression trajectories among women. | Gillis JC et al. | — | 2019 | → |
| The role of telomeres and telomerase in cirrhosis and liver cancer. | Nault JC et al. | — | 2019 | → |
| Transfused trauma patients have better outcomes when transfused with blood components from young donors. | Amico F et al. | — | 2019 | → |
| A crucial role of ROCK for alleviation of senescence-associated phenotype. | Park JT et al. | — | 2018 | → |
| Age and cytogenetic abnormalities. | Souza CA | — | 2018 | → |
| Ageing at the level of telomeres in association to residential landscape and air pollution at home and work: a review of the current evidence. | Martens DS et al. | — | 2018 | → |
| A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation. | Beermann J et al. | — | 2018 | → |
| Characterization in humans of <i>in vitro</i> leucocyte maximal telomerase activity capacity and association with stress. | de Punder K et al. | — | 2018 | → |
| Ectothermic telomeres: it's time they came in from the cold. | Olsson M et al. | — | 2018 | → |
| Energy Producing Metabolic Pathways in Functional Regulation of the Hematopoietic Stem Cells. | Roy IM et al. | — | 2018 | → |
| Environmentally relevant concentrations of di(2-ethylhexyl)phthalate exposure alter larval growth and locomotion in medaka fish via multiple pathways. | Yang WK et al. | — | 2018 | → |
| Epidemiological and cytogenetic profiles of patients with hematological malignancies and their relationship with aging. | Alves ASBM et al. | — | 2018 | → |
| Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice. | Xie K et al. | — | 2018 | → |
| Evolutionary ecology of telomeres: a review. | Olsson M et al. | — | 2018 | → |
| Experimental manipulation of telomere length: does it reveal a corner-stone role for telomerase in the natural variability of individual fitness? | Criscuolo F et al. | — | 2018 | → |
| Frailty in people living with HIV. | Bloch M | — | 2018 | → |
| Genetic cartography of longevity in humans and mice: Current landscape and horizons. | Hook M et al. | — | 2018 | → |
| Heart-Breaking Telomeres. | Martínez P et al. | — | 2018 | → |
| hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction. | Guha M et al. | — | 2018 | → |
| Increased risk of dementia in patients with Schizophrenia: A population-based cohort study in Taiwan. | Lin CE et al. | — | 2018 | → |
| Long-term Persistent Organic Pollutants Exposure Induced Telomere Dysfunction and Senescence-Associated Secretary Phenotype. | Yuan J et al. | — | 2018 | → |
| Mesenchymal Stem Cells from Cervix and Age: New Insights into CIN Regression Rate. | Orciani M et al. | — | 2018 | → |
| Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder. | Mellon SH et al. | — | 2018 | → |
| Mitochondria, its DNA and telomeres in ageing and human population. | Zole E et al. | — | 2018 | → |
| Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking. | Faraji J et al. | — | 2018 | → |
| Photo-Powered Artificial Organelles for ATP Generation and Life-Sustainment. | Zheng DW et al. | — | 2018 | → |
| Rejuvenation by cell reprogramming: a new horizon in gerontology. | Goya RG et al. | — | 2018 | → |
| Resveratrol counteracts bone loss via mitofilin-mediated osteogenic improvement of mesenchymal stem cells in senescence-accelerated mice. | Lv YJ et al. | — | 2018 | → |
| Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells. | Richardson GD et al. | — | 2018 | → |
| Telomere length in psychiatric disorders: Is it more than an ageing marker? | Monroy-Jaramillo N et al. | — | 2018 | → |
| The aging heart. | Obas V et al. | — | 2018 | → |
| The Emerging Roles for Telomerase in the Central Nervous System. | Liu MY et al. | — | 2018 | → |
| The fetal programming of telomere biology hypothesis: an update. | Entringer S et al. | — | 2018 | → |
| The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence. | Mohrin M et al. | — | 2018 | → |
| "Till Death Do Us Part": A Potential Irreversible Link Between Aberrant Cell Cycle Control and Neurodegeneration in the Adult Olfactory Bulb. | Omais S et al. | — | 2018 | → |
| 2,4,6-Trinitrotoluene Induces Apoptosis via ROS-Regulated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in HepG2 and Hep3B Cells. | Liao HY et al. | — | 2017 | → |
| Adipose-Derived Mesenchymal Stem Cells from the Elderly Exhibit Decreased Migration and Differentiation Abilities with Senescent Properties. | Liu M et al. | — | 2017 | → |
| Associations Between Age, Psychosocial Work Conditions, Occupational Well-Being, and Telomere Length in Geriatric Care Professionals: A Mixed-Methods Study. | Chmelar C et al. | — | 2017 | → |
| Cxcl14 depletion accelerates skeletal myogenesis by promoting cell cycle withdrawal. | Waldemer-Streyer RJ et al. | — | 2017 | → |
| Defects in lymphocyte telomere homeostasis contribute to cellular immune phenotype in patients with cartilage-hair hypoplasia. | Aubert G et al. | — | 2017 | → |
| Downregulation of CITED2 contributes to TGFβ-mediated senescence of tendon-derived stem cells. | Hu C et al. | — | 2017 | → |
| Dried plum and chokeberry ameliorate d-galactose-induced aging in mice by regulation of Pl3k/Akt-mediated Nrf2 and Nf-kB pathways. | Jeong H et al. | — | 2017 | → |
| Hippocampal TERT Regulates Spatial Memory Formation through Modulation of Neural Development. | Zhou QG et al. | — | 2017 | → |
| Impact of Dehydroepiandrosterone Sulfate on Newborn Leukocyte Telomere Length. | Liu H et al. | — | 2017 | → |
| Influence of Aging and Environment on Presentation of Infection in Older Adults. | El Chakhtoura NG et al. | — | 2017 | → |
| Interleukin-7 and Immunosenescence. | Nguyen V et al. | — | 2017 | → |
| Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain. | Andriani GA et al. | — | 2017 | → |
| Mechanisms of lung aging. | Brandenberger C et al. | — | 2017 | → |
| Mitochondrial regulation of hematopoietic stem cells. | Snoeck HW | — | 2017 | → |
| Optimizing stem cells for cardiac repair: Current status and new frontiers in regenerative cardiology. | Der Sarkissian S et al. | — | 2017 | → |
| PIM1-minicircle as a therapeutic treatment for myocardial infarction. | Liu N et al. | — | 2017 | → |
| Plasminogen activator inhibitor-1 is associated with leukocyte telomere length in American Indians: findings from the Strong Heart Family Study. | Peng H et al. | — | 2017 | → |
| Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome. | Wheaton K et al. | — | 2017 | → |
| Relative Telomere Repeat Mass in Buccal and Leukocyte-Derived DNA. | Finnicum CT et al. | — | 2017 | → |
| Senescence is not inevitable. | Jones OR et al. | — | 2017 | → |
| Shining the Light on Senescence Associated LncRNAs. | Ghanam AR et al. | — | 2017 | → |
| Stem cell therapies in age-related neurodegenerative diseases and stroke. | Wang Y et al. | — | 2017 | → |
| Targeting of AUF1 to vascular endothelial cells as a novel anti-aging therapy. | He J et al. | — | 2017 | → |
| Tendon injuries: Basic science and new repair proposals. | Wu F et al. | — | 2017 | → |
| The 99th percentile of reference population for cTnI and cTnT assay: methodology, pathophysiology and clinical implications. | Clerico A et al. | — | 2017 | → |
| The ageing genome, clonal mosaicism and chronic disease. | Machiela MJ et al. | — | 2017 | → |
| Transcriptional Signatures of Aging. | Stegeman R et al. | — | 2017 | → |
| Transcriptomic responses of the endangered freshwater mussel Margaritifera margaritifera to trace metal contamination in the Dronne River, France. | Bertucci A et al. | — | 2017 | → |
| Treadmill running prevents age-related memory deficit and alters neurotrophic factors and oxidative damage in the hippocampus of Wistar rats. | Vanzella C et al. | — | 2017 | → |
| WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1. | Sun L et al. | — | 2017 | → |
| Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase. | Okada M et al. | — | 2016 | → |
| Ageing and the telomere connection: An intimate relationship with inflammation. | Zhang J et al. | — | 2016 | → |
| Aging and computational systems biology. | Mooney KM et al. | — | 2016 | → |
| Air Pollution Stress and the Aging Phenotype: The Telomere Connection. | Martens DS et al. | — | 2016 | → |
| A Systematic Investigation into Aging Related Genes in Brain and Their Relationship with Alzheimer's Disease. | Meng G et al. | — | 2016 | → |
| Ataxia telangiectasia presenting as hyper IgM syndrome without neurologic signs. | Doshi A et al. | — | 2016 | → |
| Atorvastatin Therapy Modulates Telomerase Activity in Patients Free of Atherosclerotic Cardiovascular Diseases. | Strazhesko ID et al. | — | 2016 | → |
| Biomolecular Markers within the Core Axis of Aging and Particulate Air Pollution Exposure in the Elderly: A Cross-Sectional Study. | Pieters N et al. | — | 2016 | → |
| Conditional Loss of Pten in Myogenic Progenitors Leads to Postnatal Skeletal Muscle Hypertrophy but Age-Dependent Exhaustion of Satellite Cells. | Yue F et al. | — | 2016 | → |
| Control of stress signaling in stem cells: crossroads of stem cells and cancer. | Cho SJ et al. | — | 2016 | → |
| Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging? | Shalev I et al. | — | 2016 | → |
| Epigenetics and Primary Biliary Cirrhosis: a Comprehensive Review and Implications for Autoimmunity. | Xie YQ et al. | — | 2016 | → |
| Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience. | Huffman DM et al. | — | 2016 | → |
| Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice. | Safdar A et al. | — | 2016 | → |
| Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells. | Carrero D et al. | — | 2016 | → |
| Impact of biological aging on arterial aging in American Indians: findings from the Strong Heart Family Study. | Peng H et al. | — | 2016 | → |
| Implants for the aged patient: biological, clinical and sociological considerations. | Bartold PM et al. | — | 2016 | → |
| Increased Age-Related Cardiac Dysfunction in Bradykinin B2 Receptor-Deficient Mice. | Feng W et al. | — | 2016 | → |
| Interactions between UCP2 SNPs and telomere length exist in the absence of diabetes or pre-diabetes. | Zhou Y et al. | — | 2016 | → |
| Leukocyte mitochondrial DNA copy number, anthropometric indices, and weight change in US women. | Meng S et al. | — | 2016 | → |
| Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia. | Zambetti NA et al. | — | 2016 | → |
| Mitochondrial metabolic failure in telomere attrition-provoked aging of bone marrow mesenchymal stem cells. | Sui B et al. | — | 2016 | → |
| Mitochondria: Major Regulators of Neural Development. | Xavier JM et al. | — | 2016 | → |
| Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells. | Mungenast AE et al. | — | 2016 | → |
| Molecular insights into the premature aging disease progeria. | Vidak S et al. | — | 2016 | → |
| Mouse models of ageing and their relevance to disease. | Kõks S et al. | — | 2016 | → |
| P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan. | Giorgio M et al. | — | 2016 | → |
| Parallel telomere shortening in multiple body tissues owing to malaria infection. | Asghar M et al. | — | 2016 | → |
| Pathways for salvage and protection of the heart under stress: novel routes for cardiac rejuvenation. | Cannatà A et al. | — | 2016 | → |
| Race, Ethnicity, Psychosocial Factors, and Telomere Length in a Multicenter Setting. | Lynch SM et al. | — | 2016 | → |
| Reactivation of telomerase in cancer. | Akincilar SC et al. | — | 2016 | → |
| Role of Telomeres and Telomerase in Aging and Cancer. | Shay JW | — | 2016 | → |
| Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish. | Carneiro MC et al. | — | 2016 | → |
| Stem cell mitochondria during aging. | Min-Wen JC et al. | — | 2016 | → |
| Targeting mTOR signaling by polyphenols: A new therapeutic target for ageing. | Pazoki-Toroudi H et al. | — | 2016 | → |
| Telomere attrition and restoration in the normal teleost Oryzias latipes are linked to growth rate and telomerase activity at each life stage. | Hatakeyama H et al. | — | 2016 | → |
| Telomere shortening and telomerase activity in ischaemic cardiomyopathy patients - Potential markers of ventricular arrhythmia. | Sawhney V et al. | — | 2016 | → |
| The Human Microcirculation: Regulation of Flow and Beyond. | Gutterman DD et al. | — | 2016 | → |
| Therapeutic Targeting of Telomerase. | Jäger K et al. | — | 2016 | → |
| The sirtuins: Markers of metabolic health. | Covington JD et al. | — | 2016 | → |
| Ultraviolet Radiation-Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging. | Panich U et al. | — | 2016 | → |
| Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance. | van Beek JH et al. | — | 2016 | → |
| Aging Leads to a Dysregulation in Mechanically Driven Bone Formation and Resorption. | Razi H et al. | — | 2015 | → |
| Assessment of DNA damage and repair efficiency in drug naïve schizophrenia using comet assay. | Muraleedharan A et al. | — | 2015 | → |
| Association of relative telomere length with cardiovascular disease in a large chronic kidney disease cohort: the GCKD study. | Raschenberger J et al. | — | 2015 | → |
| Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults. | Tyrka AR et al. | — | 2015 | → |
| Autologous Stem Cell Therapy: How Aging and Chronic Diseases Affect Stem and Progenitor Cells. | Efimenko AY et al. | — | 2015 | → |
| Changes in Regenerative Capacity through Lifespan. | Yun MH | — | 2015 | → |
| Chronic infection. Hidden costs of infection: chronic malaria accelerates telomere degradation and senescence in wild birds. | Asghar M et al. | — | 2015 | → |
| Comparison of telomere length between population-specific mitochondrial haplogroups among different age groups in a Latvian population. | Zole E et al. | — | 2015 | → |
| Concise review: hematopoietic stem cell aging and the prospects for rejuvenation. | Wahlestedt M et al. | — | 2015 | → |
| Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells. | Lamb R et al. | — | 2015 | → |
| DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function. | Yu Q et al. | — | 2015 | → |
| Dynamic regulation of cerebral DNA repair genes by psychological stress. | Forsberg K et al. | — | 2015 | → |
| Effects of PTEN on the longevity of cultured human umbilical vein endothelial cells: the role of antioxidants. | Tait IS et al. | — | 2015 | → |
| Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging. | Crane JD et al. | — | 2015 | → |
| Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro. | Paine HA et al. | — | 2015 | → |
| <i>Hydra</i> as a tractable, long-lived model system for senescence. | Bellantuono AJ et al. | — | 2015 | → |
| Impact of intrauterine tobacco exposure on fetal telomere length. | Salihu HM et al. | — | 2015 | → |
| Measuring the aging process in stem cells. | Liu Y et al. | — | 2015 | → |
| Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging. | Ziegler DV et al. | — | 2015 | → |
| Mitochondrial swelling and restorable fragmentation stimulated by femtosecond laser. | Shi F et al. | — | 2015 | → |
| Naive T cell maintenance and function in human aging. | Goronzy JJ et al. | — | 2015 | → |
| Pharmacogenomic analysis indicates potential of 1,5-isoquinolinediol as a universal anti-aging agent for different tissues. | Park MS et al. | — | 2015 | → |
| Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases. | Yang J et al. | — | 2015 | → |
| Telomere dynamics in parasitic great spotted cuckoos and their magpie hosts. | Soler JJ et al. | — | 2015 | → |
| Telomere Length in Peripheral Blood Mononuclear Cells of Patients on Chronic Hemodialysis Is Related With Telomerase Activity and Treatment Duration. | Stefanidis I et al. | — | 2015 | → |
| Telopodes of telocytes are influenced in vitro by redox conditions and ageing. | Enciu AM et al. | — | 2015 | → |
| The association between leukocyte telomere lengths and sleep instability based on cardiopulmonary coupling analysis. | Kwon AM et al. | — | 2015 | → |
| The changes of leukocyte telomere length and telomerase activity after sitagliptin intervention in newly diagnosed type 2 diabetes. | Ma D et al. | — | 2015 | → |
| The GSK-3 family as therapeutic target for myocardial diseases. | Lal H et al. | — | 2015 | → |
| The melanocyte lineage in development and disease. | Mort RL et al. | — | 2015 | → |
| The Role of the Microenvironmental Niche in Declining Stem-Cell Functions Associated with Biological Aging. | DeCarolis NA et al. | — | 2015 | → |
| Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell-based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telomerase activation therapies. | Babizhayev MA et al. | — | 2015 | → |
| Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation. | Imai R et al. | — | 2015 | → |
| Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells. | Ramunas J et al. | — | 2015 | → |
| Adipose-derived mesenchymal stromal cells from aged patients with coronary artery disease keep mesenchymal stromal cell properties but exhibit characteristics of aging and have impaired angiogenic potential. | Efimenko A et al. | — | 2014 | → |
| A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects. | McClay JL et al. | — | 2014 | → |
| An integrative review of factors associated with telomere length and implications for biobehavioral research. | Starkweather AR et al. | — | 2014 | → |
| Anti-senescence efficacy of radio-electric asymmetric conveyer technology. | Maioli M et al. | — | 2014 | → |
| Autologous bone marrow mononuclear cell infusion and hyperbaric oxygen therapy in type 2 diabetes mellitus: an open-label, randomized controlled clinical trial. | Wu Z et al. | — | 2014 | → |
| Brain-skin connection: stress, inflammation and skin aging. | Chen Y et al. | — | 2014 | → |
| Cellular aging of skeletal muscle: telomeric and free radical evidence that physical inactivity is responsible and not age. | Venturelli M et al. | — | 2014 | → |
| Curcumin enhances parental reproductive lifespan and progeny viability in Drosophila melanogaster. | Chandrashekara KT et al. | — | 2014 | → |
| Effects of TP53 mutational status on gene expression patterns across 10 human cancer types. | Parikh N et al. | — | 2014 | → |
| Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells. | Le R et al. | — | 2014 | → |
| Experimentally increased reproductive effort alters telomere length in the blue tit (Cyanistes caeruleus). | Sudyka J et al. | — | 2014 | → |
| Extracting extra-telomeric phenotypes from telomerase mouse models. | Sung YH et al. | — | 2014 | → |
| Genetics of aging, progeria and lamin disorders. | Ghosh S et al. | — | 2014 | → |
| Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium. | Loffredo FS et al. | — | 2014 | → |
| Hematopoietic stem cell aging and chronic lymphocytic leukemia pathogenesis. | Kikushige Y et al. | — | 2014 | → |
| Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation injury through AMPK/eNOS/PGC-1α signaling pathway. | Hu L et al. | — | 2014 | → |
| Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response. | Dang W et al. | — | 2014 | → |
| Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing. | Rossiello F et al. | — | 2014 | → |
| Migration and stress during reproduction govern telomere dynamics in a seabird. | Schultner J et al. | — | 2014 | → |
| Mitochondria as signaling organelles. | Chandel NS | — | 2014 | → |
| Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: a shared pathology via oxidative stress and mitochondrial dysfunction? | Bullon P et al. | — | 2014 | → |
| p53: the barrier to cancer stem cell formation. | Aloni-Grinstein R et al. | — | 2014 | → |
| Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. | Huang Q et al. | — | 2014 | → |
| Repair of endogenous DNA base lesions modulate lifespan in mice. | Meira LB et al. | — | 2014 | → |
| Senescence in adipose-derived stem cells and its implications in nerve regeneration. | Mantovani C et al. | — | 2014 | → |
| Senescent remodeling of the innate and adaptive immune system in the elderly men with prostate cancer. | Taverna G et al. | — | 2014 | → |
| Stem cell aging: mechanisms, regulators and therapeutic opportunities. | Oh J et al. | — | 2014 | → |
| Stem cells, redox signaling, and stem cell aging. | Liang R et al. | — | 2014 | → |
| Stem cells: the pursuit of genomic stability. | Wyles SP et al. | — | 2014 | → |
| Subtelomeric CTCF and cohesin binding site organization using improved subtelomere assemblies and a novel annotation pipeline. | Stong N et al. | — | 2014 | → |
| TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas. | Sun CK et al. | — | 2014 | → |
| Telomerase as a "stemness" enzyme. | Kong F et al. | — | 2014 | → |
| Telomeres shorten in response to oxidative stress in mouse skeletal muscle fibers. | Ludlow AT et al. | — | 2014 | → |
| The circadian rhythm controls telomeres and telomerase activity. | Chen WD et al. | — | 2014 | → |
| The convergence of fracture repair and stem cells: interplay of genes, aging, environmental factors and disease. | Hadjiargyrou M et al. | — | 2014 | → |
| The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease. | Horan MP et al. | — | 2014 | → |
| The history of sleep apnea is associated with shorter leukocyte telomere length: the Helsinki Birth Cohort Study. | Savolainen K et al. | — | 2014 | → |
| The impact of influenza vaccination on hospitalizations and mortality among frail older people. | Lee WJ et al. | — | 2014 | → |
| The rejuvenation of aged stem cells for cardiac repair. | Ludke A et al. | — | 2014 | → |
| The two-faced progeria gene and its implications in aging and metabolism. | Chatzispyrou IA et al. | — | 2014 | → |
| Transcriptional outcome of telomere signalling. | Ye J et al. | — | 2014 | → |
| Variation of DNA methylation in candidate age-related targets on the mitochondrial-telomere axis in cord blood and placenta. | Janssen BG et al. | — | 2014 | → |
| Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background. | Yao YG et al. | — | 2013 | → |
| A natural product telomerase activator as part of a health maintenance program: metabolic and cardiovascular response. | Harley CB et al. | — | 2013 | → |
| Association between oxidative stress and telomere length in Type 1 and Type 2 diabetic patients. | Ma D et al. | — | 2013 | → |
| Brief report: The potential role of epigenetics on multipotent cell differentiation capacity of mesenchymal stromal cells. | Yannarelli G et al. | — | 2013 | → |
| Causes, consequences, and reversal of immune system aging. | Montecino-Rodriguez E et al. | — | 2013 | → |
| Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair. | Cho JS et al. | — | 2013 | → |
| Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA/RNA damage. | Jorgensen A et al. | — | 2013 | → |
| Dachshund binds p53 to block the growth of lung adenocarcinoma cells. | Chen K et al. | — | 2013 | → |
| Detectable clonal mosaicism in the human genome. | Machiela MJ et al. | — | 2013 | → |
| Diminished response to in vivo mechanical loading in trabecular and not cortical bone in adulthood of female C57Bl/6 mice coincides with a reduction in deformation to load. | Willie BM et al. | — | 2013 | → |
| DNA methylome: Unveiling your biological age. | Li M et al. | — | 2013 | → |
| Forkhead box(O) in control of reactive oxygen species and genomic stability to ensure healthy lifespan. | Charitou P et al. | — | 2013 | → |
| Frailty in elderly people. | Clegg A et al. | — | 2013 | → |
| 'From death, lead me to immortality' - mantra of ageing skeletal muscle. | Saini A et al. | — | 2013 | → |
| Hutchinson-Gilford progeria syndrome through the lens of transcription. | Prokocimer M et al. | — | 2013 | → |
| Increased systemic oxidatively generated DNA and RNA damage in schizophrenia. | Jorgensen A et al. | — | 2013 | → |
| Increased telomere length and proliferative potential in peripheral blood mononuclear cells of adults of different ages stimulated with concanavalin A. | Murillo-Ortiz B et al. | — | 2013 | → |
| Lin28: primal regulator of growth and metabolism in stem cells. | Shyh-Chang N et al. | — | 2013 | → |
| Loss of telomere protection: consequences and opportunities. | Jacobs JJ | — | 2013 | → |
| Male breast cancer, age and sex chromosome aneuploidy. | Jacobs PA et al. | — | 2013 | → |
| Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length. | Entringer S et al. | — | 2013 | → |
| Mechanisms that regulate stem cell aging and life span. | Signer RA et al. | — | 2013 | → |
| Mitochondria and tumor progression in ulcerative colitis. | Ussakli CH et al. | — | 2013 | → |
| Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials. | Macpherson H et al. | — | 2013 | → |
| Oxidative stress in aging--matters of the heart and mind. | Venkataraman K et al. | — | 2013 | → |
| Peroxisome proliferator-activated-γ coactivator-1α-mediated mitochondrial biogenesis is important for hematopoietic recovery in response to stress. | Basu S et al. | — | 2013 | → |
| SIRT3 reverses aging-associated degeneration. | Brown K et al. | — | 2013 | → |
| Stem cell function and maintenance - ends that matter: role of telomeres and telomerase. | Saeed H et al. | — | 2013 | → |
| Stem cell metabolism in tissue development and aging. | Shyh-Chang N et al. | — | 2013 | → |
| Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy. | Jorgensen A et al. | — | 2013 | → |
| Telomerase as a useful target in cancer fighting-the breast cancer case. | Holysz H et al. | — | 2013 | → |
| Telomerase downregulation induces proapoptotic genes expression and initializes breast cancer cells apoptosis followed by DNA fragmentation in a cell type dependent manner. | Rubis B et al. | — | 2013 | → |
| Telomerase is required for zebrafish lifespan. | Henriques CM et al. | — | 2013 | → |
| Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy. | Fyhrquist F et al. | — | 2013 | → |
| Translocations in normal B cells and cancers: insights from new technical approaches. | Chiarle R | — | 2013 | → |
| Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. | Deschênes-Simard X et al. | — | 2013 | → |
| Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degeneration. | Kohler J et al. | — | 2013 | → |
| A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. | Wang J et al. | — | 2012 | → |
| Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction. | Molano A et al. | — | 2012 | → |
| Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline. | Kohama SG et al. | — | 2012 | → |
| Age related changes of the extracellular matrix and stem cell maintenance. | Kurtz A et al. | — | 2012 | → |
| Age-related cognitive decline: can neural stem cells help us? | Artegiani B et al. | — | 2012 | → |
| Aging and reprogramming: a two-way street. | Mahmoudi S et al. | — | 2012 | → |
| Aging mechanisms in bone. | Almeida M | — | 2012 | → |
| Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation. | Hrdlicková R et al. | — | 2012 | → |
| Alternative strategy for Alzheimer's disease: stress response triggers. | Smith Sonneborn J | — | 2012 | → |
| Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. | Hu J et al. | — | 2012 | → |
| Assessing cell and organ senescence biomarkers. | Bernardes de Jesus B et al. | — | 2012 | → |
| Axis of ageing: telomeres, p53 and mitochondria. | Sahin E et al. | — | 2012 | → |
| B cell maintenance and function in aging. | Kogut I et al. | — | 2012 | → |
| Chromothripsis and human disease: piecing together the shattering process. | Maher CA et al. | — | 2012 | → |
| Concise review: hematopoietic stem cell aging, life span, and transplantation. | Van Zant G et al. | — | 2012 | → |
| Consequences of telomere shortening during lifespan. | Henriques CM et al. | — | 2012 | → |
| Detectable clonal mosaicism and its relationship to aging and cancer. | Jacobs KB et al. | — | 2012 | → |
| Detectable clonal mosaicism from birth to old age and its relationship to cancer. | Laurie CC et al. | — | 2012 | → |
| Distinct mobilization of circulating CD271+ mesenchymal progenitors from hematopoietic progenitors during aging and after myocardial infarction. | Iso Y et al. | — | 2012 | → |
| Evolution of the cancer genome. | Podlaha O et al. | — | 2012 | → |
| Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma. | Deng Z et al. | — | 2012 | → |
| FOXOs and sirtuins in vascular growth, maintenance, and aging. | Oellerich MF et al. | — | 2012 | → |
| Genetically engineered mouse models and human osteosarcoma. | Ng AJ et al. | — | 2012 | → |
| Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches. | Conboy IM et al. | — | 2012 | → |
| HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells. | Zhang H et al. | — | 2012 | → |
| Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair. | Mohsin S et al. | — | 2012 | → |
| Hypoxic preconditioning--a cutting "aged" remedy for impaired angiogenesis. | Bando YK et al. | — | 2012 | → |
| Induction of muscle regeneration by RNA-mediated mitochondrial restoration. | Jash S et al. | — | 2012 | → |
| Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged people. | Bonafè M et al. | — | 2012 | → |
| Ink4-Arf locus in cancer and aging. | Sherr CJ | — | 2012 | → |
| In situ guided tissue regeneration in musculoskeletal diseases and aging : Implementing pathology into tailored tissue engineering strategies. | Jakob F et al. | — | 2012 | → |
| Metabolic plasticity in stem cell homeostasis and differentiation. | Folmes CD et al. | — | 2012 | → |
| Metabolism of the preimplantation embryo: 40 years on. | Leese HJ | — | 2012 | → |
| Mitochondria and cancer. | Wallace DC | — | 2012 | → |
| Mitochondrial function in permeabilized cardiomyocytes is largely preserved in the senescent rat myocardium. | Picard M et al. | — | 2012 | → |
| Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control. | Chen LY et al. | — | 2012 | → |
| mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription. | Pont AR et al. | — | 2012 | → |
| Nanog reverses the effects of organismal aging on mesenchymal stem cell proliferation and myogenic differentiation potential. | Han J et al. | — | 2012 | → |
| Neural stem cell deforestation as the main force driving the age-related decline in adult hippocampal neurogenesis. | Encinas JM et al. | — | 2012 | → |
| Oncogenic challenges in stem cells and the link to cancer initiation. | Lee JS et al. | — | 2012 | → |
| Osteoarthritis year 2011 in review: biology. | Lotz M | — | 2012 | → |
| Prenatal stress, telomere biology, and fetal programming of health and disease risk. | Entringer S et al. | — | 2012 | → |
| Progeroid syndromes: models for stem cell aging? | Bellantuono I et al. | — | 2012 | → |
| Prolonged expression of senescence markers in mice exposed to gamma-irradiation. | Seol MA et al. | — | 2012 | → |
| Role of microRNA processing in adipose tissue in stress defense and longevity. | Mori MA et al. | — | 2012 | → |
| RPE cell senescence: a key contributor to age-related macular degeneration. | Kozlowski MR | — | 2012 | → |
| Telomere dysfunction and its role in haematological cancer. | Jones CH et al. | — | 2012 | → |
| Telomere length in early life predicts lifespan. | Heidinger BJ et al. | — | 2012 | → |
| Telomere length, telomerase activity and osteogenic differentiation are maintained in adipose-derived stromal cells from senile osteoporotic SAMP6 mice. | Mirsaidi A et al. | — | 2012 | → |
| Telomeres and mitochondria in the aging heart. | Moslehi J et al. | — | 2012 | → |
| Telomeres, atherosclerosis, and the hemothelium: the longer view. | Aviv A et al. | — | 2012 | → |
| Telomere shortening in women resident close to waste landfill sites. | De Felice B et al. | — | 2012 | → |
| The alternative lengthening of telomeres pathway may operate in non-neoplastic human cells. | Slatter TL et al. | — | 2012 | → |
| The impact of a pathogenic bacterium on a social carnivore population. | Höner OP et al. | — | 2012 | → |
| The intersection between aging and cardiovascular disease. | North BJ et al. | — | 2012 | → |
| The role of DNA exonucleases in protecting genome stability and their impact on ageing. | Mason PA et al. | — | 2012 | → |
| 3D imaging of telomeres and nuclear architecture: An emerging tool of 3D nano-morphology-based diagnosis. | Knecht H et al. | — | 2011 | → |
| Accelerated aging syndromes, are they relevant to normal human aging? | Dreesen O et al. | — | 2011 | → |
| Accurate quantification of more than 4000 mouse tissue proteins reveals minimal proteome changes during aging. | Walther DM et al. | — | 2011 | → |
| Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: implications for early intervention and therapeutics. | Mao P et al. | — | 2011 | → |
| Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection? | Henry CJ et al. | — | 2011 | → |
| Aging of the subventricular zone neural stem cell niche. | Conover JC et al. | — | 2011 | → |
| Association of an UCP4 (SLC25A27) haplotype with ultra-resistant schizophrenia. | Mouaffak F et al. | — | 2011 | → |
| At the stem of youth and health. | Beltrami AP et al. | — | 2011 | → |
| Biologic function and clinical potential of telomerase and associated proteins in cardiovascular tissue repair and regeneration. | Madonna R et al. | — | 2011 | → |
| Cancer genomes evolve by pulverizing single chromosomes. | Meyerson M et al. | — | 2011 | → |
| Carbamylated low-density lipoprotein induces oxidative stress and accelerated senescence in human endothelial progenitor cells. | Carracedo J et al. | — | 2011 | → |
| Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA. | Xu Y | — | 2011 | → |
| Chromatin regulation and genome maintenance by mammalian SIRT6. | Tennen RI et al. | — | 2011 | → |
| [Chronic inflammation and biomarkers. Is ageing an expression of chronic inflammation?]. | Schmidt D et al. | — | 2011 | → |
| Comparison of telomere length and association with progenitor cell markers in lacrimal gland between Sjögren syndrome and non-Sjögren syndrome dry eye patients. | Kawashima M et al. | — | 2011 | → |
| Differences in disease severity but similar telomere lengths in genetic subgroups of patients with telomerase and shelterin mutations. | Vulliamy TJ et al. | — | 2011 | → |
| Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita. | Zhong F et al. | — | 2011 | → |
| Drug-induced senescence generates chemoresistant stemlike cells with low reactive oxygen species. | Achuthan S et al. | — | 2011 | → |
| Effects of age and heart failure on human cardiac stem cell function. | Cesselli D et al. | — | 2011 | → |
| Emerging models and paradigms for stem cell ageing. | Jones DL et al. | — | 2011 | → |
| Epigenetic regulation of aging stem cells. | Pollina EA et al. | — | 2011 | → |
| Expansions of NK-like αβT cells with chronologic aging: novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells. | Vallejo AN et al. | — | 2011 | → |
| Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1. | Rhee DB et al. | — | 2011 | → |
| Genetically engineered murine models--contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma. | Chesler L et al. | — | 2011 | → |
| Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging. | Bocker MT et al. | — | 2011 | → |
| HIV infection, inflammation, immunosenescence, and aging. | Deeks SG | — | 2011 | → |
| Human telomerase expression regulation. | Gladych M et al. | — | 2011 | → |
| Hydrogen peroxide induces Sp1 methylation and thereby suppresses cyclin B1 via recruitment of Suv39H1 and HDAC1 in cancer cells. | Chuang JY et al. | — | 2011 | → |
| Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewal. | Wang J et al. | — | 2011 | → |
| Is telomerase a potential target for vascular rejuvenation? | Spyridopoulos I | — | 2011 | → |
| Macromolecular deterioration as the ultimate constraint on human lifespan. | Truscott RJ | — | 2011 | → |
| Manifestations and mechanisms of stem cell aging. | Liu L et al. | — | 2011 | → |
| Massive genomic rearrangement acquired in a single catastrophic event during cancer development. | Stephens PJ et al. | — | 2011 | → |
| Measurement of telomere DNA content by dot blot analysis. | Kimura M et al. | — | 2011 | → |
| Merging personalized medicine and biology of aging in chronic obstructive pulmonary disease. | Shapiro SD | — | 2011 | → |
| Mice as a mammalian model for research on the genetics of aging. | Yuan R et al. | — | 2011 | → |
| Mitochondria as a therapeutic target for aging and neurodegenerative diseases. | Reddy PH et al. | — | 2011 | → |
| Molecular genetic epidemiology of age-related hearing impairment. | Uchida Y et al. | — | 2011 | → |
| Morphofunctional and Biochemical Approaches for Studying Mitochondrial Changes during Myoblasts Differentiation. | Barbieri E et al. | — | 2011 | → |
| Pathways to aging: the mitochondrion at the intersection of biological and psychosocial sciences. | Picard M | — | 2011 | → |
| PGC-1α regulates translocated in liposarcoma activity: role in oxidative stress gene expression. | Sánchez-Ramos C et al. | — | 2011 | → |
| Physical activity and telomere biology: exploring the link with aging-related disease prevention. | Ludlow AT et al. | — | 2011 | → |
| Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state. | Lapasset L et al. | — | 2011 | → |
| Separation of telomerase functions by reverse genetics. | Mukherjee S et al. | — | 2011 | → |
| Sex differences in telomeres and lifespan. | Barrett EL et al. | — | 2011 | → |
| SIRT6 is required for maintenance of telomere position effect in human cells. | Tennen RI et al. | — | 2011 | → |
| Smooth muscle cells for vascular engineering. | Chen YE et al. | — | 2011 | → |
| Telomerase deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation. | Findeisen HM et al. | — | 2011 | → |
| Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. | Jaskelioff M et al. | — | 2011 | → |
| Telomere dysfunction and cell cycle checkpoints in hematopoietic stem cell aging. | Ju Z et al. | — | 2011 | → |
| Telomere dysfunction induces metabolic and mitochondrial compromise. | Sahin E et al. | — | 2011 | → |
| Telomere length in cardiovascular disease: new challenges in measuring this marker of cardiovascular aging. | Hoffmann J et al. | — | 2011 | → |
| Telomeres and telomerase in renal health. | Wills LP et al. | — | 2011 | → |
| The PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro. | Liu S et al. | — | 2011 | → |
| The Regulation of Aging and Longevity: A New and Complex Role of p53. | Feng Z et al. | — | 2011 | → |
| Translational regulation in nutrigenomics. | Liu B et al. | — | 2011 | → |
| Unraveling the role of FoxOs in bone--insights from mouse models. | Almeida M | — | 2011 | → |
| Ageing and neurodegenerative diseases. | Hung CW et al. | — | 2010 | → |
| Aging and bone. | Boskey AL et al. | — | 2010 | → |
| Anemia, fatigue and aging. | Balducci L | — | 2010 | → |
| A novel source of tetraploid cancer cell precursors: telomere insufficiency links aging to oncogenesis. | Castedo M et al. | — | 2010 | → |
| Current status of GV1001 and other telomerase vaccination strategies in the treatment of cancer. | Shaw VE et al. | — | 2010 | → |
| Genomic comparison of the ants Camponotus floridanus and Harpegnathos saltator. | Bonasio R et al. | — | 2010 | → |
| Mitochondrial rejuvenation after induced pluripotency. | Suhr ST et al. | — | 2010 | → |
| Normal stem cells and cancer stem cells: similar and different. | Shackleton M | — | 2010 | → |
| Peroxisome proliferator-activated receptors gamma coactivator-1alpha: master regulator of mitochondrial biogenesis and survival during critical illness? | Crouser ED | — | 2010 | → |
| Rejuvenating somatotropic signaling: a therapeutical opportunity for premature aging? | Ugalde AP et al. | — | 2010 | → |
| Stem cells and neuroprotection: understanding the players. | Pearce V | — | 2010 | → |
| Telomerase deficiency impairs glucose metabolism and insulin secretion. | Kuhlow D et al. | — | 2010 | → |
| Telomerase: structure, functions, and activity regulation. | Zvereva MI et al. | — | 2010 | → |
| The DNA damage response: making it safe to play with knives. | Ciccia A et al. | — | 2010 | → |
| The patterns and dynamics of genomic instability in metastatic pancreatic cancer. | Campbell PJ et al. | — | 2010 | → |
| The role of telomeres and telomerase in stem cell aging. | Flores I et al. | — | 2010 | → |
| Treatment of cancer in the older aged person. | Balducci L | — | 2010 | → |