Association within a family of a balanced autosomal translocation with major mental illness.
paper
Cited
Public
Unavailable
- Authors
- St Clair, D; Blackwood, D; Muir, W; Carothers, A; Walker, M; Spowart, G; Gosden, C; Evans, H J
- Year
- 1990
- Journal
- Lancet (London, England)
- PMID
- 1973210
- DOI
- 10.1016/0140-6736(90)91520-k
282 pedigrees in the MRC Cytogenetics Registry, Edinburgh, with familial autosomal anomalies were examined for the presence of associated mental illness. In one large pedigree there were 23 cases of mental and/or behavioural disorders meeting Research Diagnostic Criteria. 34 of the 77 family members available for cytogenetic analysis carried a balanced translocation t(1:11) (q43,q21). Psychiatric diagnoses had been recorded for 16 of the 34 members with the translocation compared with only 5 of the 43 without it. The lod scores (against chance linkage of the translocation with mental illness) were greatest when the mental disorders in the phenotype were restricted to schizophrenia, schizoaffective disorder, recurrent major depression, and adolescent conduct and emotional disorders. Although the mental illness in this family may not be typical of that in the general population, the findings suggest that the q21-22 region of chromosome 11 may be a promising area to examine for genes predisposing to major mental illness.
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| NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'. | Bradshaw NJ et al. | β | 2013 | β |
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| Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. | Ma TM et al. | β | 2013 | β |
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| Questions about DISC1 as a genetic risk factor for schizophrenia. | Sullivan PF | β | 2013 | β |
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| Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction. | Gamo NJ et al. | β | 2013 | β |
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| Using rodents to model schizophrenia and substance use comorbidity. | Ng E et al. | β | 2013 | β |
| What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn. | Kendler KS | β | 2013 | β |
| A commentary on the gender-specific association of TSNAX/DISC1 locus for schizophrenia and bipolar affective disorder in South Indian population. | Numata S | β | 2012 | β |
| Aggregated proteins in schizophrenia and other chronic mental diseases: DISC1opathies. | Korth C | β | 2012 | β |
| AKT/GSK3 signaling pathway and schizophrenia. | Emamian ES | β | 2012 | β |
| Analysis of the DISC1 translocation partner (11q14.3) in genetic risk of schizophrenia. | Debono R et al. | β | 2012 | β |
| Application of reprogrammed patient cells to investigate the etiology of neurological and psychiatric disorders. | Christian KM et al. | β | 2012 | β |
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| A simple cell-based assay reveals that diverse neuropsychiatric risk genes converge on primary cilia. | Marley A et al. | β | 2012 | β |
| Avoiding mouse traps in schizophrenia genetics: lessons and promises from current and emerging mouse models. | Kvajo M et al. | β | 2012 | β |
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| Effects of a mis-sense DISC1 variant on brain activation in two cohorts at high risk of bipolar disorder or schizophrenia. | Whalley HC et al. | β | 2012 | β |
| Gender-specific association of TSNAX/DISC1 locus for schizophrenia and bipolar affective disorder in South Indian population. | Ram Murthy A et al. | β | 2012 | β |
| Generation, purification, and characterization of cell-invasive DISC1 protein species. | Bader V et al. | β | 2012 | β |
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| Genetic association of cyclic AMP signaling genes with bipolar disorder. | McDonald ML et al. | β | 2012 | β |
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| Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling. | Gupta A et al. | β | 2012 | β |
| Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia. | Mathieson I et al. | β | 2012 | β |
| Molecular genetics of the psychosis phenotype. | DeRosse P et al. | β | 2012 | β |
| Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ΞΆ deficiency. | Cheah PS et al. | β | 2012 | β |
| New frontiers in animal research of psychiatric illness. | Kaffman A et al. | β | 2012 | β |
| Schizophrenia genes: on the matter of their convergence. | Rujescu D | β | 2012 | β |
| Synaptic dysfunction in schizophrenia. | Yin DM et al. | β | 2012 | β |
| The DISC1 promoter: characterization and regulation by FOXP2. | Walker RM et al. | β | 2012 | β |
| The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population. | Wei Q et al. | β | 2012 | β |
| Wnt signaling: role in Alzheimer disease and schizophrenia. | Inestrosa NC et al. | β | 2012 | β |
| A Novel Microduplication in the Neurodevelopmental Gene SRGAP3 That Segregates with Psychotic Illness in the Family of a COS Proband. | Wilson NK et al. | β | 2011 | β |
| A population genetic approach to mapping neurological disorder genes using deep resequencing. | Myers RA et al. | β | 2011 | β |
| Association study between Disrupted-in-Schizophrenia-1 (DISC1) and Japanese patients with treatment-resistant schizophrenia (TRS). | Hotta Y et al. | β | 2011 | β |
| Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. | Kuroda K et al. | β | 2011 | β |
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| Cellular reprogramming: recent advances in modeling neurological diseases. | Ming GL et al. | β | 2011 | β |
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| CTLA-4 confers a risk of recurrent schizophrenia, major depressive disorder and bipolar disorder in the Chinese Han population. | Liu J et al. | β | 2011 | β |
| Dendritic spine pathology in neuropsychiatric disorders. | Penzes P et al. | β | 2011 | β |
| DISC1: a schizophrenia gene with multiple personalities. | Wexler EM et al. | β | 2011 | β |
| DISC1 exon 11 rare variants found more commonly in schizoaffective spectrum cases than controls. | Green EK et al. | β | 2011 | β |
| DISC1 in schizophrenia: genetic mouse models and human genomic imaging. | Johnstone M et al. | β | 2011 | β |
| Disrupted-in-Schizophrenia-1 (Disc1) is necessary for migration of the pyramidal neurons during mouse hippocampal development. | Tomita K et al. | β | 2011 | β |
| Do we have any solid evidence of clinical utility about the pathophysiology of schizophrenia? | Lawrie SM et al. | β | 2011 | β |
| Evidence for association between Disrupted-in-Schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based association study. | Zheng F et al. | β | 2011 | β |
| Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes. | Katsel P et al. | β | 2011 | β |
| Genome arrays for the detection of copy number variations in idiopathic mental retardation, idiopathic generalized epilepsy and neuropsychiatric disorders: lessons for diagnostic workflow and research. | Hochstenbach R et al. | β | 2011 | β |
| Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients. | Buizer-Voskamp JE et al. | β | 2011 | β |
| Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes. | Carless MA et al. | β | 2011 | β |
| Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation. | Chiang CH et al. | β | 2011 | β |
| Linking neurodevelopmental and synaptic theories of mental illness through DISC1. | Brandon NJ et al. | β | 2011 | β |
| Myelin, copper, and the cuprizone model of schizophrenia. | Herring NR et al. | β | 2011 | β |
| Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. | Balu DT et al. | β | 2011 | β |
| No association of the YWHAE gene with schizophrenia, major depressive disorder or bipolar disorder in the Han Chinese population. | Liu J et al. | β | 2011 | β |
| Progress in defining the biological causes of schizophrenia. | Pickard B | β | 2011 | β |
| Regulation of the cytoskeleton by Disrupted-in-schizophrenia 1 (DISC1). | Wang Q et al. | β | 2011 | β |
| Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population. | Moens LN et al. | β | 2011 | β |
| Structure and evolutionary history of DISC1. | Sanchez-Pulido L et al. | β | 2011 | β |
| The effects of DISC1 risk variants on brain activation in controls, patients with bipolar disorder and patients with schizophrenia. | Chakirova G et al. | β | 2011 | β |
| The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. | Wang Q et al. | β | 2011 | β |
| Two patients walk into a clinic...a genomics perspective on the future of schizophrenia. | Corvin AP | β | 2011 | β |
| A Hybrid Machine Learning Method for Fusing fMRI and Genetic Data: Combining both Improves Classification of Schizophrenia. | Yang H et al. | β | 2010 | β |
| A threonine to isoleucine missense mutation in the pericentriolar material 1 gene is strongly associated with schizophrenia. | Datta SR et al. | β | 2010 | β |
| Candidate genes and their interactions with other genetic/environmental risk factors in the etiology of schizophrenia. | Prasad KM et al. | β | 2010 | β |
| Cognition in mouse models of schizophrenia susceptibility genes. | Arguello PA et al. | β | 2010 | β |
| Cytosolic protein interactions of the schizophrenia susceptibility gene dysbindin. | Mead CL et al. | β | 2010 | β |
| DISC1 duplication in two brothers with autism and mild mental retardation. | Crepel A et al. | β | 2010 | β |
| DISC1 regulates primary cilia that display specific dopamine receptors. | Marley A et al. | β | 2010 | β |
| Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1. | Hayashi-Takagi A et al. | β | 2010 | β |
| Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha. | Carroll LS et al. | β | 2010 | β |
| Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging. | Nicodemus KK et al. | β | 2010 | β |
| Genetics in schizophrenia: where are we and what next? | Tiwari AK et al. | β | 2010 | β |
| Is glycogen synthase kinase-3 a central modulator in mood regulation? | Li X et al. | β | 2010 | β |
| MicroRNA dysregulation in psychiatric disease. | Miller BH et al. | β | 2010 | β |
| Molecules, signaling, and schizophrenia. | Kvajo M et al. | β | 2010 | β |
| Nature and nurture in neuropsychiatric genetics: where do we stand? | Dick DM et al. | β | 2010 | β |
| No evidence that rare coding variants in ZNF804A confer risk of schizophrenia. | Dwyer S et al. | β | 2010 | β |
| Replication of association between working memory and Reelin, a potential modifier gene in schizophrenia. | Wedenoja J et al. | β | 2010 | β |
| Signaling pathways in schizophrenia: emerging targets and therapeutic strategies. | Karam CS et al. | β | 2010 | β |
| Signal integration through blending, bolstering and bifurcating of intracellular information. | Pawson CT et al. | β | 2010 | β |
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| The genetics of major depression: moving beyond the monoamine hypothesis. | Shyn SI et al. | β | 2010 | β |
| The neuregulin signaling pathway and schizophrenia: from genes to synapses and neural circuits. | Buonanno A | β | 2010 | β |
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| A genome screen of 35 bipolar affective disorder pedigrees provides significant evidence for a susceptibility locus on chromosome 15q25-26. | McAuley EZ et al. | β | 2009 | β |
| A genome-wide investigation of SNPs and CNVs in schizophrenia. | Need AC et al. | β | 2009 | β |
| Altered growth factor signaling pathways as the basis of aberrant stem cell maturation in schizophrenia. | Kalkman HO | β | 2009 | β |
| Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. | Tomppo L et al. | β | 2009 | β |
| Association between the serotonin 2A receptor gene and bipolar affective disorder in an Australian cohort. | McAuley EZ et al. | β | 2009 | β |
| Association of variants in DISC1 with psychosis-related traits in a large population cohort. | Tomppo L et al. | β | 2009 | β |
| Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder. | Anitha A et al. | β | 2009 | β |
| Construction of balanced translocation t(1;11)(q42.1;q14.3) probe and screening application in genomic samples in Taiwan. | Liu YL et al. | β | 2009 | β |
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| DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms. | Nakata K et al. | β | 2009 | β |
| DISCopathies: brain disorders related to DISC1 dysfunction. | Korth C | β | 2009 | β |
| Does the presenilin 2 gene predispose to schizophrenia? | Zhang J et al. | β | 2009 | β |
| Fine mapping on chromosome 10q22-q23 implicates Neuregulin 3 in schizophrenia. | Chen PL et al. | β | 2009 | β |
| Gene models of schizophrenia: DISC1 mouse models. | Jaaro-Peled H | β | 2009 | β |
| Genetics of bipolar disorder: successful start to a long journey. | Craddock N et al. | β | 2009 | β |
| Modeling cognitive endophenotypes of schizophrenia in mice. | Kellendonk C et al. | β | 2009 | β |
| Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1. | Jaaro-Peled H et al. | β | 2009 | β |
| New findings from genetic association studies of schizophrenia. | Williams HJ et al. | β | 2009 | β |
| No pathogenic rearrangement within the DISC 1 gene in psychosis. | Legallic S et al. | β | 2009 | β |
| Oligomer assembly of the C-terminal DISC1 domain (640-854) is controlled by self-association motifs and disease-associated polymorphism S704C. | Leliveld SR et al. | β | 2009 | β |
| Schizophrenia genetics: new insights from new approaches. | Williams HJ et al. | β | 2009 | β |
| Survey of schizophrenia and bipolar disorder candidate genes using chromatin immunoprecipitation and tiled microarrays (ChIP-chip). | Pedrosa E et al. | β | 2009 | β |
| The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations. | Schumacher J et al. | β | 2009 | β |
| The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia. | Takahashi T et al. | β | 2009 | β |
| The genetics of bipolar disorder. | Barnett JH et al. | β | 2009 | β |
| The role of DNA copy number variation in schizophrenia. | Tam GW et al. | β | 2009 | β |
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| Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex. | Colantuoni C et al. | β | 2008 | β |
| A glimmer of light for neuropsychiatric disorders. | Hyman SE | β | 2008 | β |
| An interview with... Cliff Tabin. | Tabin C | β | 2008 | β |
| Association of DISC1 with autism and Asperger syndrome. | Kilpinen H et al. | β | 2008 | β |
| Clinical perspectives on the genetics of schizophrenia: a bottom-up orientation. | Verhoeven WM et al. | β | 2008 | β |
| Copy variations in schizophrenia and bipolar disorder. | Lachman HM | β | 2008 | β |
| DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia. | Szeszko PR et al. | β | 2008 | β |
| DISC1 mRNA expression is not influenced by common Cis-acting regulatory polymorphisms or imprinting. | Hayesmoore JB et al. | β | 2008 | β |
| Disrupted-in-Schizophrenia-1. | Muir WJ et al. | β | 2008 | β |
| Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder. | Anitha A et al. | β | 2008 | β |
| Gene expression in the etiology of schizophrenia. | Bray NJ | β | 2008 | β |
| Genome-wide linkage scan, fine mapping, and haplotype analysis in a large, inbred, Arab Israeli pedigree suggest a schizophrenia susceptibility locus on chromosome 20p13. | Teltsh O et al. | β | 2008 | β |
| Hypofrontality in subjects at high genetic risk of schizophrenia with depressive symptoms. | Whalley HC et al. | β | 2008 | β |
| Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia. | Song W et al. | β | 2008 | β |
| Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia. | Pletnikov MV et al. | β | 2008 | β |
| Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease. | Leliveld SR et al. | β | 2008 | β |
| Isolated populations and complex disease gene identification. | Kristiansson K et al. | β | 2008 | β |
| Mitochondrial disorders in the nervous system. | DiMauro S et al. | β | 2008 | β |
| Psychiatric genetics: progress amid controversy. | Burmeister M et al. | β | 2008 | β |
| Psychiatric genetics: The brains of the family. | Abbott A | β | 2008 | β |
| Recurrent CNVs disrupt three candidate genes in schizophrenia patients. | Vrijenhoek T et al. | β | 2008 | β |
| Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. | Shen S et al. | β | 2008 | β |
| Sequence analysis of P21-activated kinase 3 (PAK3) in chronic schizophrenia with cognitive impairment. | Morrow EM et al. | β | 2008 | β |
| The DISC locus in psychiatric illness. | Chubb JE et al. | β | 2008 | β |
| Top-down or bottom-up: Contrasting perspectives on psychiatric diagnoses. | Verhoeven WM et al. | β | 2008 | β |
| Association of distinct allelic haplotypes of DISC1 with psychotic and bipolar spectrum disorders and with underlying cognitive impairments. | Palo OM et al. | β | 2007 | β |
| A strategy for identifying phenotypic subtypes: concordance of symptom dimensions between sibling pairs who met screening criteria for a genetic linkage study of childhood-onset bipolar disorder using the Child Bipolar Questionnaire. | Papolos D et al. | β | 2007 | β |
| Case-control association study of Disrupted-in-Schizophrenia-1 (DISC1) gene and schizophrenia in the Chinese population. | Chen QY et al. | β | 2007 | β |
| Chasing genes for mood disorders and schizophrenia in genetically isolated populations. | Venken T et al. | β | 2007 | β |
| Cortical mapping of genotype-phenotype relationships in schizophrenia. | Bearden CE et al. | β | 2007 | β |
| Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1. | Hennah W et al. | β | 2007 | β |
| Fine mapping by genetic association implicates the chromosome 1q23.3 gene UHMK1, encoding a serine/threonine protein kinase, as a novel schizophrenia susceptibility gene. | Puri V et al. | β | 2007 | β |
| Functional genomics and schizophrenia: endophenotypes and mutant models. | Waddington JL et al. | β | 2007 | β |
| Increase in GSK3beta gene copy number variation in bipolar disorder. | Lachman HM et al. | β | 2007 | β |
| PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation. | Pletnikov MV et al. | β | 2007 | β |
| Phenotypic and genetic complexity of psychosis. Invited commentary on ... Schizophrenia: a common disease caused by multiple rare alleles. | Craddock N et al. | β | 2007 | β |
| Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han population. | Qu M et al. | β | 2007 | β |
| Relative risk of glucose elevation during antipsychotic exposure in a Veterans Administration population. | Duncan E et al. | β | 2007 | β |
| Schizophrenia: a common disease caused by multiple rare alleles. | McClellan JM et al. | β | 2007 | β |
| Schizophrenia in translation: disrupted in schizophrenia (DISC1): integrating clinical and basic findings. | Roberts RC | β | 2007 | β |
| Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. | Li W et al. | β | 2007 | β |
| Susceptibility genes for schizophrenia: characterisation of mutant mouse models at the level of phenotypic behaviour. | O'Tuathaigh CM et al. | β | 2007 | β |
| Array-based genomic delineation of a familial duplication 11q14.1-q22.1 associated with recurrent depression. | Kolomietz E et al. | β | 2006 | β |
| Association study of a functional promoter polymorphism in the XBP1 gene and schizophrenia. | JΓΆnsson EG et al. | β | 2006 | β |
| A two-stage linkage analysis of Chinese schizophrenia pedigrees in 10 target chromosomes. | Zheng Y et al. | β | 2006 | β |
| Carving chaos: genetics and the classification of mood and psychotic syndromes. | Potash JB | β | 2006 | β |
| Contributions of molecular biology to antipsychotic drug discovery: promises fulfilled or unfulfilled? | Roth BL | β | 2006 | β |
| Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder. | Pickard BS et al. | β | 2006 | β |
| DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex. | Kirkpatrick B et al. | β | 2006 | β |
| Disrupted in schizophrenia 1: building brains and memories. | Porteous DJ et al. | β | 2006 | β |
| Disrupted-in-schizophrenia-1 (DISC1): a key susceptibility factor for major mental illnesses. | Sawamura N et al. | β | 2006 | β |
| Endophenotypes in the genetic analyses of mental disorders. | Cannon TD et al. | β | 2006 | β |
| Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs. | Lipska BK et al. | β | 2006 | β |
| Failure to confirm allelic association between markers at the CAPON gene locus and schizophrenia in a British sample. | Puri V et al. | β | 2006 | β |
| Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 in the region of the gene encoding the regulator of G-protein signaling 4 protein (RGS4). | Rizig MA et al. | β | 2006 | β |
| Functional genomics in postmortem human brain: abnormalities in a DISC1 molecular pathway in schizophrenia. | Lipska BK et al. | β | 2006 | β |
| Gene regulation by hypoxia and the neurodevelopmental origin of schizophrenia. | Schmidt-Kastner R et al. | β | 2006 | β |
| Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness. | Hennah W et al. | β | 2006 | β |
| Genetic association between schizophrenia and the DISC1 gene in the Scottish population. | Zhang F et al. | β | 2006 | β |
| Imaging genomics and response to treatment with antipsychotics in schizophrenia. | Blasi G et al. | β | 2006 | β |
| Lissencephaly 1 linking to multiple diseases: mental retardation, neurodegeneration, schizophrenia, male sterility, and more. | Reiner O et al. | β | 2006 | β |
| Neuroimaging-genetic paradigms: a new approach to investigate the pathophysiology and treatment of cognitive deficits in schizophrenia. | Roffman JL et al. | β | 2006 | β |
| Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele. | Blair IP et al. | β | 2006 | β |
| Psychosis pathways converge via D2high dopamine receptors. | Seeman P et al. | β | 2006 | β |
| Schizophrenia: an integrative approach to modelling a complex disorder. | Robertson GS et al. | β | 2006 | β |
| The genetics and biology of DISC1--an emerging role in psychosis and cognition. | Porteous DJ et al. | β | 2006 | β |
| Variations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar subjects from mediterranean Spain: a preliminary study. | TabarΓ©s-Seisdedos R et al. | β | 2006 | β |
| A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. | Sawamura N et al. | β | 2005 | β |
| A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3. | Ogawa F et al. | β | 2005 | β |
| A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia. | Hennah W et al. | β | 2005 | β |
| Association between genotype at an exonic SNP in DISC1 and normal cognitive aging. | Thomson PA et al. | β | 2005 | β |
| Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population. | Thomson PA et al. | β | 2005 | β |
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| Excitement and confusion on chromosome 6q: the challenges of neuropsychiatric genetics in microcosm. | Kohn Y et al. | β | 2005 | β |
| Expanding the 'central dogma': the regulatory role of nonprotein coding genes and implications for the genetic liability to schizophrenia. | Perkins DO et al. | β | 2005 | β |
| Mapping auditory core, lateral belt, and parabelt cortices in the human superior temporal gyrus. | Sweet RA et al. | β | 2005 | β |
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| Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. | Callicott JH et al. | β | 2005 | β |
| A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42. | Macgregor S et al. | β | 2004 | β |
| A novel permutation testing method implicates sixteen nicotinic acetylcholine receptor genes as risk factors for smoking in schizophrenia families. | Faraone SV et al. | β | 2004 | β |
| Clinical phenotypes associated with DISC1, a candidate gene for schizophrenia. | Blackwood DH et al. | β | 2004 | β |
| DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness. | Millar JK et al. | β | 2004 | β |
| Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. | Hodgkinson CA et al. | β | 2004 | β |
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| Genomewide linkage scan for bipolar-disorder susceptibility loci among Ashkenazi Jewish families. | Fallin MD et al. | β | 2004 | β |
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| Replication of 1q42 linkage in Finnish schizophrenia pedigrees. | Ekelund J et al. | β | 2004 | β |
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