Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation.
paper
Cited
Public
Unavailable
- Authors
- Chiang, C-H; Su, Y; Wen, Z; Yoritomo, N; Ross, C A; Margolis, R L; Song, H; Ming, G-L
- Year
- 2011
- Journal
- Molecular psychiatry
- PMID
- 21339753
- DOI
- 10.1038/mp.2011.13
- PMCID
- PMC4005725
Characterization of iPSC lines from two schizophrenia patients with a DISC1 mutation and a healthy subject. (a) Sample phase images of iPSCs derived from two schizophrenia patients with a DISC1 mutation (D1 and D2) and from a control subject (C1). Scale bar: 100 ΞΌm. (b) Sample confocal images of immunostaining of pluripotency markers, Nanog and Oct4, and DAPI. Scale bar: 100 ΞΌm. (c) Normal karyotypes of derived iPSCs. (d) Methylation status of CpGs in the promoter regions of Nanog and Oct4. Open and close circles represent unmethylated and methylated CpGs, respectively. (e) Sample H&E staining images of teratomas formed by iPSCs injected into adult SCID/Beige mice. Scale bar: 100 ΞΌm. (f) Genomic sequencing analysis of the 4 bp deletion in iPSCs. (g) PCR-based demonstration of the lack of plasmid sequences in the genomic DNA of iPSCs.
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