The association between depressive symptoms from early to late adolescence and later use and harmful use of alcohol.
paper
Cited
Public
- Authors
- Edwards, Alexis C; Joinson, Carol; Dick, Danielle M; Kendler, Kenneth S; Macleod, John; Munafò, Marcus; Hickman, Matthew; Lewis, Glyn; Heron, Jon
- Year
- 2014
- Journal
- European child & adolescent psychiatry
- PMID
- 25130265
- DOI
- 10.1007/s00787-014-0600-5
- PMCID
- PMC4246124
Depressive symptoms and alcohol misuse contribute substantially to the global health burden. These phenotypes often manifest, and frequently co-occur, during adolescence. However, few studies have examined whether both baseline levels of depressive symptoms and change in symptoms are associated with alcohol outcomes. In addition, inconsistent findings could be due to sex differences or the use of different alcohol outcomes. Using data from a prospective population-based cohort in the UK, we estimated trajectories of depressive symptoms from 12 years 10 months to 17 years 10 months, separately for male and female participants. We assessed whether baseline and change in depressive symptoms were associated with use and harmful use of alcohol at 18 years 8 months. Among females, increasing depressive symptoms were associated with increased alcohol use; whilst for males, there was little evidence of this. When examining harmful levels of alcohol use, baseline levels of depressive symptoms in males were weakly related to later harmful alcohol use but this association was attenuated substantially through adjustment for confounders. In contrast, both baseline symptoms and increase in symptoms were associated with later harmful alcohol use in females and these associations were not diminished by confounder adjustment. Elevated depressive symptoms during adolescence are positively associated with increases in both use and harmful use of alcohol at 18 years 8 months. These findings differ between the sexes. Further research is needed to examine the mechanisms underlying the link between depressive symptoms and harmful alcohol use to identify potentially modifiable factors for intervention.
Multiple-indicator growth model with latent measure of alcohol consumption as distal outcome
Estimated trajectories of depressive symptoms across adolescence (first MFQ indicator) for (i) males and (ii) females with data for at least 2 waves
| # | Section | Preview |
|---|---|---|
| 40 | Discussion — Mechanisms and implications | In contrast to the finding for females, there was no evidence that increasing levels of depressive… |
| 41 | Discussion — Mechanisms and implications | More generally, depressive and anxiety symptoms could lead to alcohol misuse via expectations about… |
| 42 | Discussion — Overall conclusions and further work | The current study uses longitudinal data from a large, population-based sample, and benefits from… |
| 43 | Discussion — Overall conclusions and further work | substance use [44]. The finding that the nature of the alcohol outcome may be critical in… |
| 44 | Electronic supplementary material | Below is the link to the electronic supplementary material. Supplementary material 1 (DOCX 38 kb) |
← Prev
41–45 of 45
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study. | 2017 | 28073157 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The Sex-Dependent Relationship Between Amygdala Activation and Depressive Symptoms With Problematic Drinking. | Rosenthal A et al. | — | 2026 | → |
| A narrative review on alcohol use in women: insight into the telescoping hypothesis from a biopsychosocial perspective. | Kirsch DE et al. | — | 2025 | → |
| A network approach to personality vulnerability symptom structure across early, middle, and late adolescence: Insights from a large-scale sample. | Deng Y et al. | — | 2025 | → |
| Developmental trajectories of child and adolescent emotional problems: associations with early adult alcohol use behaviors. | Chen T et al. | — | 2025 | → |
| Disentangling developmental trajectories of childhood anxiety and depression symptoms in the prediction of adolescent substance use. | Bowie KLM et al. | — | 2025 | → |
| Examining polygenic scores for depression, depressive symptoms from childhood to adolescence, and adolescent substance use in a diverse sample: The moderating impact of a family-centered intervention. | Elam KK et al. | — | 2025 | → |
| Species differences in comorbid alcohol use disorder and major depressive disorder: A narrative review. | Winkler GA et al. | — | 2025 | → |
| Adolescent predictors of psychiatric disorders in adulthood: The role of emotional distress and problem drinking in emerging adulthood. | Neppl TK et al. | — | 2024 | → |
| Individual Trajectories of Depressive Symptoms Within Racially-Ethnically Diverse Youth: Associations with Polygenic Risk for Depression and Substance Use Intent and Perceived Harm. | Elam KK et al. | — | 2024 | → |
| Effectiveness of Family-Involved Interventions in Reducing Co-Occurring Alcohol Use and Mental Health Problems in Young People Aged 12-17: A Systematic Review and Meta-Analysis. | Geijer-Simpson E et al. | — | 2023 | → |
| How are young people's mental health related to their sexual health and substance use? A systematic review of UK literature. | Harmanci D et al. | — | 2023 | → |
| Prevalence and associated factors of probable depression amongst pregnant and parenting young females: a comparison of adolescents and young adults in rural South Africa. | Seakamela KP et al. | — | 2023 | → |
| The association of alcohol dependence and consumption during adolescence with depression in young adulthood, in England: a prospective cohort study. | Hammerton G et al. | — | 2023 | → |
| Areas of Convergence and Divergence in Adolescent Social Isolation and Binge Drinking: A Review. | Lodha J et al. | — | 2022 | → |
| Current Evidence and Theories in Understanding the Relationship between Cognition and Depression in Childhood and Adolescence: A Narrative Review. | Barlati S et al. | — | 2022 | → |
| Inverse probability weighting to handle attrition in cohort studies: some guidance and a call for caution. | Metten MA et al. | — | 2022 | → |
| Racial and ethnic differences in major depressive episode, severe role impairment, and mental health service utilization in U.S. adolescents. | Fan Q et al. | — | 2022 | → |
| The role of socioeconomic status in different trajectories of depressive symptoms in Chinese college freshmen. | Liu Q et al. | — | 2022 | → |
| Common mental disorders and HIV status in the context of DREAMS among adolescent girls and young women in rural KwaZulu-Natal, South Africa. | Mthiyane N et al. | — | 2021 | → |
| Early life mental health and problematic drinking in mid-adulthood: evidence from two British birth cohorts. | Ning K et al. | — | 2021 | → |
| Evaluating the influences of major depression and posttraumatic stress disorder on trauma and alcohol cue reactivity. | Bing-Canar H et al. | — | 2021 | → |
| Polygenic risk for depression, anxiety and neuroticism are associated with the severity and rate of change in depressive symptoms across adolescence. | Kwong ASF et al. | — | 2021 | → |
| The co-occurrence of mental disorders among Dutch adolescents admitted for acute alcohol intoxication. | de Veld L et al. | — | 2021 | → |
| The role of substance use coping in linking depression and alcohol use from late adolescence through early adulthood. | Magee KE et al. | — | 2021 | → |
| Aggressive-Depressive Trajectories in Childhood and Their Associations with Drinking Behaviors and Problems in Adolescence and Emerging Adulthood. | Wu WC et al. | — | 2020 | → |
| Alcohol consumption and internalising disorders in young adults of ALSPAC: a population-based study. | Fernandes GS et al. | — | 2020 | → |
| Depression, Environmental Reward, Coping Motives and Alcohol Consumption During the COVID-19 Pandemic. | McPhee MD et al. | — | 2020 | → |
| The association between early life mental health and alcohol use behaviours in adulthood: A systematic review. | Ning K et al. | — | 2020 | → |
| Age of alcohol use initiation and psychiatric symptoms among young adult trauma survivors. | Berenz EC et al. | — | 2019 | → |
| Examining the longitudinal nature of depressive symptoms in the Avon Longitudinal Study of Parents and Children (ALSPAC). | Kwong ASF | — | 2019 | → |
| Gender-specific substance use patterns and associations with individual, family, peer, and school factors in 15-year-old Portuguese adolescents: a latent class regression analysis. | Picoito J et al. | — | 2019 | → |
| Identifying Critical Points of Trajectories of Depressive Symptoms from Childhood to Young Adulthood. | Kwong ASF et al. | — | 2019 | → |
| Sex differences in stress-related alcohol use. | Peltier MR et al. | — | 2019 | → |
| Two- and three-year follow-up from a gender-specific, web-based drug abuse prevention program for adolescent girls. | Schwinn TM et al. | — | 2019 | → |
| Desvenlafaxine Versus Placebo in the Treatment of Children and Adolescents with Major Depressive Disorder. | Atkinson S et al. | — | 2018 | → |
| Identifying Critical Points of Trajectories of Depressive Symptoms From Childhood to Young Adulthood: Evidence of Sex Differences from the Avon Longitudinal Study of Parents and Children (ALSPAC) | Kwong ASF et al. | — | 2018 | — |
| Peer victimization and substance use: Understanding the indirect effect of depressive symptomatology across gender. | Zapolski TCB et al. | — | 2018 | → |
| Wine: An Aspiring Agent in Promoting Longevity and Preventing Chronic Diseases. | Pavlidou E et al. | — | 2018 | → |
| Associations between alcohol-use and depression symptoms in adolescence: Examining gender differences and pathways over time. | Danzo S et al. | — | 2017 | → |
| Bullying development across adolescence, its antecedents, outcomes, and gender-specific patterns. | Kretschmer T et al. | — | 2017 | → |
| Comparison of Parent, Peer, Psychiatric, and Cannabis Use Influences Across Stages of Offspring Alcohol Involvement: Evidence from the COGA Prospective Study. | Bucholz KK et al. | — | 2017 | → |
| Depressive symptom trajectories in late adolescence and early adulthood: A systematic review. | Schubert KO et al. | — | 2017 | → |
| Gender Differences in Risk Factors for Adolescent Binge Drinking and Implications for Intervention and Prevention. | Dir AL et al. | — | 2017 | → |
| Parental alcohol use and risk of behavioral and emotional problems in offspring. | Mahedy L et al. | — | 2017 | → |
| Patterns of cannabis use during adolescence and their association with harmful substance use behaviour: findings from a UK birth cohort. | Taylor M et al. | — | 2017 | → |
| Adolescent Alcohol Use: Protective and Predictive Parent, Peer, and Self-Related Factors. | Handren LM et al. | — | 2016 | → |
| A Functional Vesicular Monoamine Transporter 1 (VMAT1) Gene Variant Is Associated with Affect and the Prevalence of Anxiety, Affective, and Alcohol Use Disorders in a Longitudinal Population-Representative Birth Cohort Study. | Vaht M et al. | — | 2016 | → |
| Alcohol use and depression during adolescence and young adulthood: a summary and interpretation of mixed findings. | Pedrelli P et al. | — | 2016 | → |
| A prospective longitudinal model predicting early adult alcohol problems: evidence for a robust externalizing pathway. | Edwards AC et al. | — | 2016 | → |
| Pharmacokinetics and Tolerability of Single-Ascending Doses of Desvenlafaxine Administered to Children and Adolescents with Major Depressive Disorder. | Findling RL et al. | — | 2016 | → |
| Update on Substance Use in Adolescence. | Durand SC et al. | — | 2016 | → |
| Racial Differences in the Transactional Relationship Between Depression and Alcohol Use From Elementary School to Middle School. | Birkley EL et al. | — | 2015 | → |