The early time course of smoking withdrawal effects.
paper
Cited
Public
Unavailable
- Authors
- Hendricks, Peter S; Ditre, Joseph W; Drobes, David J; Brandon, Thomas H
- Year
- 2006
- Journal
- Psychopharmacology
- PMID
- 16752139
- DOI
- 10.1007/s00213-006-0429-9
RATIONALE: There has been little study of the very early time course of the smoking withdrawal syndrome, despite its relevance to the maintenance of both smoking and postcessation abstinence. The literature contains a range of estimates about the early appearance of withdrawal symptoms, but without reference to empirical data. OBJECTIVES: The study aim was to conduct a comprehensive, multimodal assessment of the early time course of the symptoms associated with smoking withdrawal among cigarette smokers. METHODS: Participants were 50 smokers randomly assigned to either abstain or smoke at their own pace during 4 h in the laboratory. Dependent measures included resting heart rate, sustained attention (Rapid Visual Information Processing task; RVIP), selective attention to smoking stimuli (an emotional Stroop task), and self-report (Wisconsin Smoking Withdrawal Scale; WSWS). After baseline assessment, participants were assigned to the two conditions and the dependent measures were collected every 30 min. RESULTS: Generalized estimating equations revealed that abstaining participants displayed greater withdrawal than smoking participants on all measures with the exception of the Stroop task. Statistically significant differences in withdrawal were found within 60 min on heart rate, within 30 min on the RVIP, and between 30 and 180 min postcessation on the various subscales of the WSWS. CONCLUSIONS: These findings provide the first evidence of the early time course of smoking withdrawal symptoms, although further research is needed to distinguish withdrawal from drug offset effects. Implications for understanding the maintenance of daily smoking and for the treatment of tobacco dependence are discussed.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A blind spot in fMRI research: Overlooked tobacco smoking-related confounds. | Koster M et al. | β | 2025 | β |
| Nicotine and neurocognition in HIV: Translational challenges and therapeutic potential. | Jha NA et al. | β | 2025 | β |
| Investigating the selective attention, attentional bias and smoking among Turkish University students: A cross-sectional study. | Taskan HS et al. | β | 2024 | β |
| Two-Hour Nicotine Withdrawal Improves Inhibitory Control Dysfunction in Male Smokers: Evidence from a Smoking-Cued Go/No-Go Task ERP Study. | Hou L et al. | β | 2024 | β |
| Development of a targeted behavioral treatment for smoking cessation among individuals with Chronic Obstructive Pulmonary Disease. | Mathew AR et al. | β | 2023 | β |
| Augmented reality for extinction of cue-provoked urges to smoke: Proof of concept. | Yang MJ et al. | β | 2022 | β |
| Not all smokers are alike: the hidden cost of sustained attention during nicotine abstinence. | Deshpande HU et al. | β | 2022 | β |
| Preliminary Evaluation of Short-Term Abstinence Effects Among Never-Smoking Experienced Users of Modern Electronic Cigarettes. | Felicione NJ et al. | β | 2022 | β |
| Tobacco cigarette smokers who endorse greater intolerance for nicotine withdrawal also report more severe insomnia symptoms. | Lape EC et al. | β | 2022 | β |
| Withdrawal: A key consideration in evaluating whether highly processed foods are addictive. | Parnarouskis L et al. | β | 2022 | β |
| Association between nicotine dependency with occupational injury in Korean men. | Jang SW et al. | β | 2021 | β |
| Possible New Symptoms of Tobacco Withdrawal III: Reduced Positive Affect-A Review and Meta-analysis. | Klemperer EM et al. | β | 2021 | β |
| Revision of the Wisconsin Smoking Withdrawal Scale: Development of brief and long forms. | Smith SS et al. | β | 2021 | β |
| Systematic Review of Nicotine Exposure's Effects on Neural Stem and Progenitor Cells. | Brooks AC et al. | β | 2021 | β |
| Temporal networks of tobacco withdrawal symptoms during smoking cessation treatment. | Lydon-Staley DM et al. | β | 2021 | β |
| Tobacco Withdrawal Symptoms Before and After Nicotine Deprivation in Veteran Smokers with Posttraumatic Stress Disorder and with Major Depressive Disorder. | Kaye JT et al. | β | 2021 | β |
| Translational Research in Nicotine Addiction. | Fisher ML et al. | β | 2021 | β |
| Conscious Abstinence from Smokeless Tobacco Evokes Higher Withdrawal Response and Impairs Cognitive Performance Independent of Sympathetic Response. | Barhwal KK et al. | β | 2020 | β |
| Differences in nicotine intake and effects from electronic and combustible cigarettes among dual users. | St Helen G et al. | β | 2020 | β |
| Investigating tobacco withdrawal in response to reduced nicotine cigarettes among smokers with opioid use disorder and other vulnerabilities. | Streck JM et al. | β | 2020 | β |
| Neural Basis of Smoking-Related Difficulties in Emotion Regulation. | Faulkner P et al. | β | 2020 | β |
| Pain characteristics and nicotine deprivation as predictors of performance during a laboratory paradigm of smoking cessation. | Powers JM et al. | β | 2020 | β |
| Possible New Symptoms of Tobacco Withdrawal II: Anhedonia-A Systematic Review. | Hughes JR et al. | β | 2020 | β |
| Severity of negative mood and anxiety symptoms occurring during acute abstinence from tobacco: A systematic review and meta-analysis. | Conti AA et al. | β | 2020 | β |
| The Interplay Between Tobacco Dependence and Sleep Quality Among Young Adults. | Cohen A et al. | β | 2020 | β |
| The Network Structure of Tobacco Withdrawal in a Community Sample of Smokers Treated With Nicotine Patch and Behavioral Counseling. | Lydon-Staley DM et al. | β | 2020 | β |
| The Relationship of Varenicline Agonism of Ξ±4Ξ²2 Nicotinic Acetylcholine Receptors and Nicotine-Induced Dopamine Release in Nicotine-Dependent Humans. | McCaul ME et al. | β | 2020 | β |
| Transcranial Direct Current Stimulation Applied to the Dorsolateral and Ventromedial Prefrontal Cortices in Smokers Modifies Cognitive Circuits Implicated in the Nicotine Withdrawal Syndrome. | Aronson Fischell S et al. | β | 2020 | β |
| Two-Hour Tobacco Abstinence Has No Effect on Cognitive Control in Male Patients With Nicotine Dependence: An ERP Study. | Xue Y et al. | β | 2020 | β |
| Brain activity associated with social exclusion overlaps with drug-related frontal-striatal circuitry in cocaine users: A pilot study. | Hanlon CA et al. | β | 2019 | β |
| Co-use of Electronic Nicotine Delivery Systems and Combustible Cigarettes, and Their Association with Internalizing Pathology and Vulnerabilities. | Versella MV et al. | β | 2019 | β |
| Distress Intolerance and Smoking Topography in the Context of a Biological Challenge. | Farris SG et al. | β | 2019 | β |
| Individual differences in emotion dysregulation and trajectory of withdrawal symptoms during a quit attempt among treatment-seeking smokers. | Rogers AH et al. | β | 2019 | β |
| Lack of utility of cigarettes per day cutoffs for clinical and laboratory smoking research. | Oliver JA et al. | β | 2019 | β |
| Neuropeptide CART prevents memory loss attributed to withdrawal of nicotine following chronic treatment in mice. | Borkar CD et al. | β | 2019 | β |
| Nicotine or expectancies? Using the balanced-placebo design to test immediate outcomes of vaping. | Palmer AM et al. | β | 2019 | β |
| Scalar-on-function regression for predicting distal outcomes from intensively gathered longitudinal data: Interpretability for applied scientists. | Dziak JJ et al. | β | 2019 | β |
| A randomized controlled trial of distress tolerance treatment for smoking cessation. | Brown RA et al. | β | 2018 | β |
| Brain substrates of early (4h) cigarette abstinence: Identification of treatment targets. | Franklin TR et al. | β | 2018 | β |
| Differential Effects of Nicotine Exposure on the Hippocampus Across Lifespan. | Zeid D et al. | β | 2018 | β |
| Functional Connectivity of the Raphe Nuclei: Link to Tobacco Withdrawal in Smokers. | Faulkner P et al. | β | 2018 | β |
| Nicotine deprivation increases pain intensity, neurogenic inflammation, and mechanical hyperalgesia among daily tobacco smokers. | Ditre JW et al. | β | 2018 | β |
| Phase IIb Trial of an Ξ±7 Nicotinic Receptor Partial Agonist With and Without Nicotine Patch for Withdrawal-Associated Cognitive Deficits and Tobacco Abstinence. | Schuster RM et al. | β | 2018 | β |
| Providing Nicotine Replacement Therapy in Focus Groups. | Jones EE et al. | β | 2018 | β |
| Anhedonia: Its Dynamic Relations With Craving, Negative Affect, and Treatment During a Quit Smoking Attempt. | Cook JW et al. | β | 2017 | β |
| A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. | Jensen KP et al. | β | 2017 | β |
| Nicotine: Sporting Friend or Foe? A Review of Athlete Use, Performance Consequences and Other Considerations. | MΓΌndel T | β | 2017 | β |
| One-Year Smoking Trajectories Among Established Adult Smokers With Low Baseline Motivation to Quit. | Mathew AR et al. | β | 2017 | β |
| Psychopathology and tobacco demand. | Farris SG et al. | β | 2017 | β |
| Self-control depletion and nicotine deprivation as precipitants of smoking cessation failure: A human laboratory model. | Heckman BW et al. | β | 2017 | β |
| Smoking-induced affect modulation in nonwithdrawn smokers with posttraumatic stress disorder, depression, and in those with no psychiatric disorder. | Cook JW et al. | β | 2017 | β |
| The Effects of Smoking Bans on Self-Assessed Health: Evidence from Germany. | Kuehnle D et al. | β | 2017 | β |
| Tobacco demand, delay discounting, and smoking topography among smokers with and without psychopathology. | Farris SG et al. | β | 2017 | β |
| What a difference a day makes: differences in initial abstinence response during a smoking cessation attempt. | Piper ME et al. | β | 2017 | β |
| Anxiety and Depression in Bidirectional Relations Between Pain and Smoking: Implications for Smoking Cessation. | Zale EL et al. | β | 2016 | β |
| Anxiety sensitivity facets in relation to tobacco use, abstinence-related problems, and cognitions in treatment-seeking smokers. | Guillot CR et al. | β | 2016 | β |
| A randomized clinical trial of a tailored behavioral smoking cessation preparation program. | McCarthy DE et al. | β | 2016 | β |
| Attentional bias to smoking and other motivationally relevant cues is affected by nicotine exposure and dose expectancy. | Robinson JD et al. | β | 2016 | β |
| Daily nicotine patch wear time predicts smoking abstinence in socioeconomically disadvantaged adults: An analysis of ecological momentary assessment data. | Ma P et al. | β | 2016 | β |
| Enhancing the effectiveness of smoking treatment research: conceptual bases and progress. | Baker TB et al. | β | 2016 | β |
| Nicotine Deprivation Produces Deficits in Pain Perception that are Moderately Attenuated by Caffeine Consumption. | Baiamonte BA et al. | β | 2016 | β |
| Progression of nicotine dependence, mood level, and mood variability in adolescent smokers. | Piasecki TM et al. | β | 2016 | β |
| Resting-state EEG, impulsiveness, and personality in daily and nondaily smokers. | Rass O et al. | β | 2016 | β |
| The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function. | McClernon FJ et al. | β | 2016 | β |
| Anhedonia as a component of the tobacco withdrawal syndrome. | Cook JW et al. | β | 2015 | β |
| Cigarette craving is associated with blunted reward processing in nicotine-dependent smokers. | Peechatka AL et al. | β | 2015 | β |
| Cortical activity differs during nicotine deprivation versus satiation in heavy smokers. | Evans DE et al. | β | 2015 | β |
| Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus. | Cohen A et al. | β | 2015 | β |
| Is impulsivity a symptom of initial tobacco withdrawal? A meta-analysis and qualitative systematic review. | Hughes JR et al. | β | 2015 | β |
| Modeling naturalistic craving, withdrawal, and affect during early nicotine abstinence: A pilot ecological momentary assessment study. | Bujarski S et al. | β | 2015 | β |
| Psychological symptoms, smoking lapse behavior, and the mediating effects of nicotine withdrawal symptoms: A laboratory study. | Ameringer KJ et al. | β | 2015 | β |
| Smoking abstinence and neurocognition: implications for cessation and relapse. | McClernon FJ et al. | β | 2015 | β |
| Time dependency of craving and response inhibition during nicotine abstinence. | Tsaur S et al. | β | 2015 | β |
| Withdrawal: Expanding a Key Addiction Construct. | Piper ME | β | 2015 | β |
| Anhedonia and the relative reward value of drug and nondrug reinforcers in cigarette smokers. | Leventhal AM et al. | β | 2014 | β |
| Associations of attention-deficit hyperactivity disorder symptom dimensions with smoking deprivation effects in adult smokers. | Bidwell LC et al. | β | 2014 | β |
| Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning. | Gould TJ et al. | β | 2014 | β |
| Clinical significance of early smoking withdrawal effects and their relationships with nicotine metabolism: preliminary results from a pilot study. | Hendricks PS et al. | β | 2014 | β |
| Cognitive function during nicotine withdrawal: Implications for nicotine dependence treatment. | Ashare RL et al. | β | 2014 | β |
| Dissociation of tolerance and nicotine withdrawal-associated deficits in contextual fear. | Gould TJ et al. | β | 2014 | β |
| Effects of exercise on craving and cigarette smoking in the human laboratory. | Kurti AN et al. | β | 2014 | β |
| Involvement of neuronal Ξ²2 subunit-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal: implications for pharmacotherapies. | Simmons SJ et al. | β | 2014 | β |
| Mindfulness predicts lower affective volatility among African Americans during smoking cessation. | Adams CE et al. | β | 2014 | β |
| Neural correlates of performance monitoring in daily and intermittent smokers. | Rass O et al. | β | 2014 | β |
| Nicotine and non-nicotine smoking factors differentially modulate craving, withdrawal and cerebral blood flow as measured with arterial spin labeling. | Addicott MA et al. | β | 2014 | β |
| Nicotine withdrawal and stress-induced changes in pain sensitivity: a cross-sectional investigation between abstinent smokers and nonsmokers. | Nakajima M et al. | β | 2014 | β |
| Small effects of smoking on visual spatiotemporal processing. | Kunchulia M et al. | β | 2014 | β |
| The effects of nicotine dose expectancy and motivationally relevant distracters on vigilance. | Robinson JD et al. | β | 2014 | β |
| Acute nicotine administration effects on fractional anisotropy of cerebral white matter and associated attention performance. | Kochunov P et al. | β | 2013 | β |
| Acute nicotine differentially impacts anticipatory valence- and magnitude-related striatal activity. | Rose EJ et al. | β | 2013 | β |
| Cigarette craving and withdrawal symptoms during temporary abstinence and the effect of nicotine gum. | Brown J et al. | β | 2013 | β |
| Effects of nicotine withdrawal on cognition in a clinical trial setting. | Wesnes KA et al. | β | 2013 | β |
| Effects of tolcapone on working memory and brain activity in abstinent smokers: a proof-of-concept study. | Ashare RL et al. | β | 2013 | β |
| Interventions for tobacco smoking. | Schlam TR et al. | β | 2013 | β |
| Investigating the impact of nicotine on executive functions using a novel virtual reality assessment. | Jansari AS et al. | β | 2013 | β |
| Neurocognitive impairments in non-deprived smokers--results from a population-based multi-center study on smoking-related behavior. | Wagner M et al. | β | 2013 | β |
| Nicotine deprivation influences P300 markers of cognitive control. | Evans DE et al. | β | 2013 | β |
| Presentation of smoking-associated cues does not elicit dopamine release after one-hour smoking abstinence: A [11C]-(+)-PHNO PET study. | Chiuccariello L et al. | β | 2013 | β |
| Psychiatric diagnoses among quitters versus continuing smokers 3 years after their quit day. | Piper ME et al. | β | 2013 | β |
| THC reduces the anticipatory nucleus accumbens response to reward in subjects with a nicotine addiction. | Jansma JM et al. | β | 2013 | β |
| The effect of withdrawal and intake of nicotine on smokers' ability to ignore distractors in a number parity decision task. | Tsiora S et al. | β | 2013 | β |
| The effects of acute abstinence from smoking and performance-based rewards on performance monitoring. | Schlienz NJ et al. | β | 2013 | β |
| Translational research in nicotine dependence. | Turner JR et al. | β | 2013 | β |
| Urge to smoke over 52Β weeks of abstinence. | Ussher M et al. | β | 2013 | β |
| Acute cigarette smoking reduces latencies on a Smoking Stroop test. | Canamar CP et al. | β | 2012 | β |
| Acute effects of cigarette smoking on insulin resistance and arterial stiffness in young adults. | Seet RC et al. | β | 2012 | β |
| Anhedonia predicts altered processing of happy faces in abstinent cigarette smokers. | Leventhal AM et al. | β | 2012 | β |
| Are tobacco dependence and withdrawal related amongst heavy smokers? Relevance to conceptualizations of dependence. | Baker TB et al. | β | 2012 | β |
| Chronic exposure to nicotine is associated with reduced reward-related activity in the striatum but not the midbrain. | Rose EJ et al. | β | 2012 | β |
| Comparative dynamics of four smoking withdrawal symptom scales. | Javitz HS et al. | β | 2012 | β |
| DSM criteria for tobacco use disorder and tobacco withdrawal: a critique and proposed revisions for DSM-5. | Baker TB et al. | β | 2012 | β |
| Life 1Β year after a quit attempt: real-time reports of quitters and continuing smokers. | Schlam TR et al. | β | 2012 | β |
| Resting state functional connectivity in addiction: Lessons learned and a road ahead. | Sutherland MT et al. | β | 2012 | β |
| Smoking cessation and quality of life: changes in life satisfaction over 3 years following a quit attempt. | Piper ME et al. | β | 2012 | β |
| Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study. | Addicott MA et al. | β | 2012 | β |
| The effects of varenicline on attention and inhibitory control among treatment-seeking smokers. | Rhodes JD et al. | β | 2012 | β |
| Why two smoking cessation agents work better than one: role of craving suppression. | Bolt DM et al. | β | 2012 | β |
| Acute effects of aerobic exercise and Hatha yoga on craving to smoke. | Elibero A et al. | β | 2011 | β |
| Attention shift towards smoking cues relates to severity of dependence, smoking behavior and breath carbon monoxide. | VollstΓ€dt-Klein S et al. | β | 2011 | β |
| Early cessation success or failure among women attempting to quit smoking: trajectories and volatility of urge and negative mood during the first postcessation week. | Cofta-Woerpel L et al. | β | 2011 | β |
| Pain, nicotine, and smoking: research findings and mechanistic considerations. | Ditre JW et al. | β | 2011 | β |
| Prospective predictors of quitting behaviours among adult smokers in six cities in China: findings from the International Tobacco Control (ITC) China Survey. | Li L et al. | β | 2011 | β |
| Varenicline effects on craving, cue reactivity, and smoking reward. | Brandon TH et al. | β | 2011 | β |
| A quantitative analysis of subjective, cognitive, and physiological manifestations of the acute tobacco abstinence syndrome. | Leventhal AM et al. | β | 2010 | β |
| Depressive mood, suicide ideation and anxiety in smokers who do and smokers who do not manage to stop smoking after a target quit day. | Berlin I et al. | β | 2010 | β |
| Meta-analysis of the acute effects of nicotine and smoking on human performance. | Heishman SJ et al. | β | 2010 | β |
| Methamphetamine dependence and neuropsychological functioning: evaluating change during early abstinence. | Simon SL et al. | β | 2010 | β |
| Nicotine modulation of information processing is not limited to input (attention) but extends to output (intention). | Rose EJ et al. | β | 2010 | β |
| Smoking withdrawal shifts the spatiotemporal dynamics of neurocognition. | Kozink RV et al. | β | 2010 | β |
| Subjective social status affects smoking abstinence during acute withdrawal through affective mediators. | Reitzel LR et al. | β | 2010 | β |
| Use of nicotine replacement therapy to treat nicotine withdrawal syndrome and aid temporary abstinence. | Foulds J | β | 2010 | β |
| Anxiety sensitivity and anxiety and depressive symptoms in the prediction of early smoking lapse and relapse during smoking cessation treatment. | Zvolensky MJ et al. | β | 2009 | β |
| Attention bias in nicotine withdrawal and under stress. | McCarthy DE et al. | β | 2009 | β |
| Momentary reductions of attention permit greater processing of irrelevant stimuli. | Weissman DH et al. | β | 2009 | β |
| Neurocognitive variation in smoking behavior and withdrawal: genetic and affective moderators. | Evans DE et al. | β | 2009 | β |
| Nicotine self-medication of cognitive-attentional processing. | Evans DE et al. | β | 2009 | β |
| Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats. | Roiko SA et al. | β | 2009 | β |
| The effect of body image threat on smoking motivation among college women: mediation by negative affect. | Lopez Khoury EN et al. | β | 2009 | β |
| The Smoking Consequences Questionnaire: Factor structure and predictive validity among Spanish-speaking Latino smokers in the United States. | Vidrine JI et al. | β | 2009 | β |
| Effects of smoking abstinence on adult smokers with and without attention deficit hyperactivity disorder: results of a preliminary study. | McClernon FJ et al. | β | 2008 | β |
| Efficacy of a nicotine (4 mg)-containing lozenge on the cognitive impairment of nicotine withdrawal. | Atzori G et al. | β | 2008 | β |
| Evaluating the validities of different DSM-IV-based conceptual constructs of tobacco dependence. | Hendricks PS et al. | β | 2008 | β |
| Physiological and psychological symptoms and predictors in early nicotine withdrawal. | Morrell HE et al. | β | 2008 | β |
| Severity of nicotine dependence moderates performance on perceptual-motor tests of attention. | Azizian A et al. | β | 2008 | β |
| Smoking is associated with worse mood on stressful days: results from a national diary study. | Aronson KR et al. | β | 2008 | β |
| Subliminal processing of smoking-related and affective stimuli in tobacco addiction. | Leventhal AM et al. | β | 2008 | β |
| The effects of acute exercise on cognitive functioning and cigarette cravings during temporary abstinence from smoking. | Janse Van Rensburg K et al. | β | 2008 | β |
| The latency to the onset of nicotine withdrawal: a test of the sensitization-homeostasis theory. | DiFranza JR et al. | β | 2008 | β |
| Atomoxetine reverses nicotine withdrawal-associated deficits in contextual fear conditioning. | Davis JA et al. | β | 2007 | β |
| Effect of tobacco deprivation on the attentional blink in rapid serial visual presentation. | Heinz A et al. | β | 2007 | β |