Evaluating the comparability of gene expression in blood and brain.
paper
Cited
Public
Unavailable
- Authors
- Sullivan, Patrick F; Fan, Cheng; Perou, Charles M
- Year
- 2006
- Journal
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- PMID
- 16526044
- DOI
- 10.1002/ajmg.b.30272
The availability of an accessible tissue whose gene expression profile is similar to more inaccessible CNS tissues has the potential to advance research in neuropsychiatric disorders. We conducted secondary data analysis of transcriptional profiling of 79 human tissues for 33,698 genes using the Affymetrix U133A microarray augmented with a custom microarray (Affymetrix GNF1H), which were produced by the Genomics Institute of the Novartis Research Foundation (http://symatlas.gnf.org). Our analyses suggested that: (a) on a transcriptome level, whole blood shares significant gene expression similarities with multiple CNS tissues; (b) the median non-parametric correlation between transcripts present in both whole blood and CNS was around 0.5; (c) this correlation of 0.5 was intermediate relative to all tissues in the Novartis data set--less than for the maximum achievable value of 0.85, less than a set of immune tissues (0.64), comparable to a heterogeneous set of somatic tissues (0.57) but greater than muscle (0.48) and peripheral nervous system tissues (0.36); (d) about half of a set of candidate genes relevant to schizophrenia were expressed in both whole blood and prefrontal cortex; and (e) the expression levels of many classes of biologically relevant processes were not significantly different between whole blood and prefrontal cortex. These analyses suggest that gene expression in whole blood is neither perfectly correlated and useful nor perfectly uncorrelated and useless with gene expression in multiple brain tissues. This suggests that the cautious and thoughtful use of peripheral gene expression may be a useful surrogate for gene expression in the CNS when it has been determined that the relevant gene is expressed in both.
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| Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes. | Parisien M et al. | β | 2017 | β |
| Examining FKBP5 mRNA expression in human iPSC-derived neural cells. | Lieberman R et al. | β | 2017 | β |
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| "Gestaltomics": Systems Biology Schemes for the Study of Neuropsychiatric Diseases. | Gutierrez Najera NA et al. | β | 2017 | β |
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| Peripheral Serotonin 1B Receptor Transcription Predicts the Effect of Acute Tryptophan Depletion on Risky Decision-Making. | Faulkner P et al. | β | 2017 | β |
| Peripheral SLC6A4 Gene Expression in Obsessive-Compulsive Disorder in the Han Chinese Population. | Wang X et al. | β | 2017 | β |
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| Similarity and Differences in Inflammation-Related Characteristics of the Peripheral Immune System of Patients with Parkinson's and Alzheimer's Diseases. | Boyko AA et al. | β | 2017 | β |
| Successful treatment with risperidone increases 5-HT 3A receptor gene expression in patients with paranoid schizophrenia - data from a prospective study. | Chen H et al. | β | 2017 | β |
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| Absolute Measurements of Macrophage Migration Inhibitory Factor and Interleukin-1-Ξ² mRNA Levels Accurately Predict Treatment Response in Depressed Patients. | Cattaneo A et al. | β | 2016 | β |
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| A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence. | Cabana-DomΓnguez J et al. | β | 2016 | β |
| Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre- and post-treatment patients with major depressive disorder. | He S et al. | β | 2016 | β |
| A Putative Blood-Based Biomarker for Autism Spectrum Disorder-Associated Ileocolitis. | Walker SJ et al. | β | 2016 | β |
| Assessing the fetal effects of maternal obesity via transcriptomic analysis of cord blood: a prospective case-control study. | Edlow AG et al. | β | 2016 | β |
| Attention: Schizophrenia Risk Gene Product miR-137 Now Targeting EFNB2. | Tooney PA | β | 2016 | β |
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| Blood gene expression studies in migraine: Potential and caveats. | Gerring Z et al. | β | 2016 | β |
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| Dysregulated 14-3-3 Family in Peripheral Blood Leukocytes of Patients with Schizophrenia. | Qing Y et al. | β | 2016 | β |
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| Effects of Lithium Monotherapy for Bipolar Disorder on Gene Expression in Peripheral Lymphocytes. | Anand A et al. | β | 2016 | β |
| Expression and methylation in posttraumatic stress disorder and resilience; evidence of a role for odorant receptors. | Chen Y et al. | β | 2016 | β |
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| Genome-Wide Changes in Peripheral Gene Expression following Sports-Related Concussion. | Merchant-Borna K et al. | β | 2016 | β |
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| Glycogen Synthase Kinase-3Ξ²: Variation over Time and the Possible Association with Mood and Cognition in Healthy Individuals. | Munkholm K et al. | β | 2016 | β |
| Insights into psychosis risk from leukocyte microRNA expression. | Jeffries CD et al. | β | 2016 | β |
| MicroRNA-137 Inhibits EFNB2 Expression Affected by a Genetic Variant and Is Expressed Aberrantly in Peripheral Blood of Schizophrenia Patients. | Wu S et al. | β | 2016 | β |
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| Preliminary evidence for association of genetic variants in pri-miR-34b/c and abnormal miR-34c expression with attention deficit and hyperactivity disorder. | Garcia-MartΓnez I et al. | β | 2016 | β |
| Progranulin deficiency induces overactivation of WNT5A expression via TNF-Ξ±/NF-ΞΊB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers. | AlquΓ©zar C et al. | β | 2016 | β |
| Seeking an objective diagnosis of depression. | Bilello JA | β | 2016 | β |
| Sports-Related Concussion Results in Differential Expression of Nuclear Factor-ΞΊB Pathway Genes in Peripheral Blood During the Acute and Subacute Periods. | Gill J et al. | β | 2016 | β |
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| The brain-derived neurotrophic factor pathway, life stress, and chronic multi-site musculoskeletal pain. | Generaal E et al. | β | 2016 | β |
| The Challenges of Precision Medicine in Obstructive Sleep Apnea. | Khalyfa A et al. | β | 2016 | β |
| The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders. | Cattaneo A et al. | β | 2016 | β |
| The oxytocin-CD38-vitamin A axis in pregnant women involves both hypothalamic and placental regulation. | Gamliel M et al. | β | 2016 | β |
| The potential of genetic and gene expression analysis in the diagnosis of neuropsychiatric disorders. | van de Leemput J et al. | β | 2016 | β |
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| Transcriptomics in Interferon-Ξ±-Treated Patients Identifies Inflammation-, Neuroplasticity- and Oxidative Stress-Related Signatures as Predictors and Correlates of Depression. | Hepgul N et al. | β | 2016 | β |
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| Warburg effect linked to cognitive-executive deficits in FMR1 premutation. | Napoli E et al. | β | 2016 | β |
| Whole-genome expression analysis reveals genes associated with treatment response to escitalopram in major depression. | Pettai K et al. | β | 2016 | β |
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| Applicability of gene expression and systems biology to develop pharmacogenetic predictors; antipsychotic-induced extrapyramidal symptoms as an example. | Mas S et al. | β | 2015 | β |
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| Changes in winter depression phenotype correlate with white blood cell gene expression profiles: a combined metagene and gene ontology approach. | Bosker FJ et al. | β | 2015 | β |
| Chromatin-Remodeling-Factor ARID1B Represses Wnt/Ξ²-Catenin Signaling. | Vasileiou G et al. | β | 2015 | β |
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| Hippocampal volume and depressive symptoms are linked to serum IL-18 in schizophrenia. | BossΓΉ P et al. | β | 2015 | β |
| Identification of collaborative activities with oxidative phosphorylation in bipolar disorder. | Sawai H et al. | β | 2015 | β |
| Increased expression of NDEL1 and MBP genes in the peripheral blood of antipsychotic-naΓ―ve patients with first-episode psychosis. | Ota VK et al. | β | 2015 | β |
| Low-variance RNAs identify Parkinson's disease molecular signature in blood. | Chikina MD et al. | β | 2015 | β |
| Messenger RNA processing is altered in autosomal dominant leukodystrophy. | Bartoletti-Stella A et al. | β | 2015 | β |
| MicroRNA circulating in the early aftermath of motor vehicle collision predict persistent pain development and suggest a role for microRNA in sex-specific pain differences. | Linnstaedt SD et al. | β | 2015 | β |
| MicroRNA expression profiles differentiate chronic pain condition subtypes. | Ciszek BP et al. | β | 2015 | β |
| Mitochondrial Citrate Transporter-dependent Metabolic Signature in the 22q11.2 Deletion Syndrome. | Napoli E et al. | β | 2015 | β |
| Mitochondrial complex I and III mRNA levels in bipolar disorder. | Akarsu S et al. | β | 2015 | β |
| MTRNR2L12: A Candidate Blood Marker of Early Alzheimer's Disease-Like Dementia in Adults with Down Syndrome. | Bik-Multanowski M et al. | β | 2015 | β |
| Network analysis of gene expression in peripheral blood identifies mTOR and NF-ΞΊB pathways involved in antipsychotic-induced extrapyramidal symptoms. | Mas S et al. | β | 2015 | β |
| Neurotrophin blood-based gene expression and social cognition analysis in patients with autism spectrum disorder. | Segura M et al. | β | 2015 | β |
| The effect of listening to music on human transcriptome. | Kanduri C et al. | β | 2015 | β |
| The Role of Epigenetic Change in Autism Spectrum Disorders. | Loke YJ et al. | β | 2015 | β |
| Transcriptome Profiling of Peripheral Blood in 22q11.2 Deletion Syndrome Reveals Functional Pathways Related to Psychosis and Autism Spectrum Disorder. | Jalbrzikowski M et al. | β | 2015 | β |
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| Blood transcriptomic biomarkers in adult primary care patients with major depressive disorder undergoing cognitive behavioral therapy. | Redei EE et al. | β | 2014 | β |
| Comparative gene expression profiling analysis of lymphoblastoid cells reveals neuron-specific enolase gene (ENO2) as a susceptibility gene of heroin dependence. | Liao DL et al. | β | 2014 | β |
| Deficits in bioenergetics and impaired immune response in granulocytes from children with autism. | Napoli E et al. | β | 2014 | β |
| Developing novel blood-based biomarkers for Alzheimer's disease. | Snyder HM et al. | β | 2014 | β |
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| Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. | McClintick JN et al. | β | 2014 | β |
| Evaluation of neurotransmitter receptor gene expression identifies GABA receptor changes: a follow-up study in antipsychotic-naΓ―ve patients with first-episode psychosis. | Ota VK et al. | β | 2014 | β |
| GC-MS based metabolomics identification of possible novel biomarkers for schizophrenia in peripheral blood mononuclear cells. | Liu ML et al. | β | 2014 | β |
| Gene-expression differences in peripheral blood between lithium responders and non-responders in the Lithium Treatment-Moderate dose Use Study (LiTMUS). | Beech RD et al. | β | 2014 | β |
| Microarray profiling and co-expression network analysis of circulating lncRNAs and mRNAs associated with major depressive disorder. | Liu Z et al. | β | 2014 | β |
| microRNAs as novel biomarkers of schizophrenia (Review). | Wang J et al. | β | 2014 | β |
| N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism. | Iwata K et al. | β | 2014 | β |
| PD_NGSAtlas: a reference database combining next-generation sequencing epigenomic and transcriptomic data for psychiatric disorders. | Zhao Z et al. | β | 2014 | β |
| Peripheral biomarkers revisited: integrative profiling of peripheral samples for psychiatric research. | Hayashi-Takagi A et al. | β | 2014 | β |
| Prenatal stress increases the striatal and hippocampal expression of correlating c-FOS and serotonin transporters in murine offspring. | Bielas H et al. | β | 2014 | β |
| Stress-related alcohol consumption in heavy drinkers correlates with expression of miR-10a, miR-21, and components of the TAR-RNA-binding protein-associated complex. | Beech RD et al. | β | 2014 | β |
| The critical need for defining preclinical biomarkers in Alzheimer's disease. | Fiandaca MS et al. | β | 2014 | β |
| Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-Ξ² accumulation modifier. | Morihara T et al. | β | 2014 | β |
| Transcriptome profiling and pathway analysis of genes expressed differentially in participants with or without a positive response to topiramate treatment for methamphetamine addiction. | Li MD et al. | β | 2014 | β |
| Understanding phenotype variability in frontotemporal lobar degeneration due to granulin mutation. | Bonvicini C et al. | β | 2014 | β |
| Assessment of gene expression in peripheral blood using RNAseq before and after weight restoration in anorexia nervosa. | Kim Y et al. | β | 2013 | β |
| Biomarker Development for Brain-Based Disorders: Recent Progress in Psychiatry. | Enaw JO et al. | β | 2013 | β |
| Coding and noncoding gene expression biomarkers in mood disorders and schizophrenia. | Mamdani F et al. | β | 2013 | β |
| Comparison of gene expression profiles in the blood, hippocampus and prefrontal cortex of rats. | Witt SH et al. | β | 2013 | β |
| Correlative gene expression pattern linking RNF123 to cellular stress-senescence genes in patients with depressive disorder: implication of DRD1 in the cerebral cortex. | Teyssier JR et al. | β | 2013 | β |
| Depression pathogenesis and treatment: what can we learn from blood mRNA expression? | Hepgul N et al. | β | 2013 | β |
| Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells. | Gardiner EJ et al. | β | 2013 | β |
| Gene expression: biomarker of antidepressant therapy? | Menke A | β | 2013 | β |
| Gene expression changes with age in skin, adipose tissue, blood and brain. | Glass D et al. | β | 2013 | β |
| Gene expression profiles in relation to tension and dissociation in borderline personality disorder. | Schmahl C et al. | β | 2013 | β |
| Gene expression profiling in treatment-naive schizophrenia patients identifies abnormalities in biological pathways involving AKT1 that are corrected by antipsychotic medication. | Kumarasinghe N et al. | β | 2013 | β |
| Increased gene expression of FOXP1 in patients with autism spectrum disorders. | Chien WH et al. | β | 2013 | β |
| Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities. | Savitz J et al. | β | 2013 | β |
| MicroRNAs as biomarkers for CNS disease. | Rao P et al. | β | 2013 | β |
| Molecular signature of disease onset in granulin mutation carriers: a gene expression analysis study. | Milanesi E et al. | β | 2013 | β |
| On the outside, looking in: a review and evaluation of the comparability of blood and brain "-omes". | Tylee DS et al. | β | 2013 | β |
| Positive correlation between serum interleukin-1Ξ² and state anger in rugby athletes. | Pesce M et al. | β | 2013 | β |
| Serum and gene expression profile of cytokines in first-episode psychosis. | Di Nicola M et al. | β | 2013 | β |
| Utilization of never-medicated bipolar disorder patients towards development and validation of a peripheral biomarker profile. | Clelland CL et al. | β | 2013 | β |
| Absence of altered expression of optineurin in primary open angle glaucoma patients. | Abu-Amero KK et al. | β | 2012 | β |
| A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes. | de Jong S et al. | β | 2012 | β |
| A molecular signature in blood identifies early Parkinson's disease. | Molochnikov L et al. | β | 2012 | β |
| Analysis of genetic expression in the soft palate of patients with obstructive sleep apnea. | Song CM et al. | β | 2012 | β |
| Blood-based gene expression profiles models for classification of subsyndromal symptomatic depression and major depressive disorder. | Yi Z et al. | β | 2012 | β |
| Blood-based gene expression signatures of infants and toddlers with autism. | Glatt SJ et al. | β | 2012 | β |
| Blood chromatin as a biosensor of the epigenetic milieu: a tool for studies in living psychiatric patients. | Sharma RP | β | 2012 | β |
| Characteristics and predictive value of blood transcriptome signature in males with autism spectrum disorders. | Kong SW et al. | β | 2012 | β |
| Comparison of brain and blood gene expression in an animal model of negative symptoms in schizophrenia. | Bosker FJ et al. | β | 2012 | β |
| Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in Tourette syndrome: a pilot study. | Tian Y et al. | β | 2012 | β |
| Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients. | Menke A et al. | β | 2012 | β |
| Finding the needle in the haystack: a review of microarray gene expression research into schizophrenia. | Kumarasinghe N et al. | β | 2012 | β |
| Functional gene-expression analysis shows involvement of schizophrenia-relevant pathways in patients with 22q11 deletion syndrome. | van Beveren NJ et al. | β | 2012 | β |
| Gene expression profiling and therapeutic interventions in neurodegenerative diseases: a comprehensive study on potentiality and limits. | Benetti F et al. | β | 2012 | β |
| Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome. | Light KC et al. | β | 2012 | β |
| Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. | Amin N et al. | β | 2012 | β |
| Genome-wide DNA methylation and gene expression analyses of monozygotic twins discordant for intelligence levels. | Yu CC et al. | β | 2012 | β |
| Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA. | Mastrokolias A et al. | β | 2012 | β |
| In vivo microRNA detection and quantitation in cerebrospinal fluid. | Gallego JA et al. | β | 2012 | β |
| Marked reduction of AKT1 expression and deregulation of AKT1-associated pathways in peripheral blood mononuclear cells of schizophrenia patients. | van Beveren NJ et al. | β | 2012 | β |
| Pilot study: potential transcription markers for adult attention-deficit hyperactivity disorder in whole blood. | GrΓΌnblatt E et al. | β | 2012 | β |
| TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disorders. | Wirgenes KV et al. | β | 2012 | β |
| Unaltered myocilin expression in the blood of primary open angle glaucoma patients. | Abu-Amero KK et al. | β | 2012 | β |
| All-trans retinoic acid upregulates reduced CD38 transcription in lymphoblastoid cell lines from Autism spectrum disorder. | Riebold M et al. | β | 2011 | β |
| An integrative functional genomics approach for discovering biomarkers in schizophrenia. | Vawter MP et al. | β | 2011 | β |
| Are retinoids potential therapeutic agents in disorders of social cognition including autism? | Ebstein RP et al. | β | 2011 | β |
| Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia. | Yamamori H et al. | β | 2011 | β |
| Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders. | Glatt SJ et al. | β | 2011 | β |
| Exon expression and alternatively spliced genes in Tourette Syndrome. | Tian Y et al. | β | 2011 | β |
| GABA- and acetylcholine-related gene expression in blood correlate with tic severity and microarray evidence for alternative splicing in Tourette syndrome: a pilot study. | Tian Y et al. | β | 2011 | β |
| Gene expression and association analysis of the epithelial membrane protein 1 gene in major depressive disorder in the Japanese population. | Nakataki M et al. | β | 2011 | β |
| Genomic and transcriptomic analyses distinguish classic Rett and Rett-like syndrome and reveals shared altered pathways. | Colak D et al. | β | 2011 | β |
| MicroRNA expression aberration as potential peripheral blood biomarkers for schizophrenia. | Lai CY et al. | β | 2011 | β |
| Peripheral biomarkers of cognitive response to dopamine receptor agonist treatment. | Ersche KD et al. | β | 2011 | β |
| Peripheral blood RNA expression profiling in illicit methcathinone users reveals effect on immune system. | Sikk K et al. | β | 2011 | β |
| Progress in defining the biological causes of schizophrenia. | Pickard B | β | 2011 | β |
| Proteomic research in psychiatry. | Taurines R et al. | β | 2011 | β |
| Similarities and differences in peripheral blood gene-expression signatures of individuals with schizophrenia and their first-degree biological relatives. | Glatt SJ et al. | β | 2011 | β |
| Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume. | Mondelli V et al. | β | 2011 | β |
| Analysis of LDLR mRNA in patients with familial hypercholesterolemia revealed a novel mutation in intron 14, which activates a cryptic splice site. | Kulseth MA et al. | β | 2010 | β |
| Analysis of peripheral immune activation in schizophrenia using quantitative reverse-transcription polymerase chain reaction (RT-PCR). | Freudenreich O et al. | β | 2010 | β |
| Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population. | Kushima I et al. | β | 2010 | β |
| Biomarkers for prediction and targeted prevention of Alzheimer's and Parkinson's diseases: evaluation of drug clinical efficacy. | Mandel SA et al. | β | 2010 | β |
| Blood mononuclear cell gene expression signature of postpartum depression. | Segman RH et al. | β | 2010 | β |
| cDNA microarray analysis of gene expression in the cerebral cortex and hippocampus of BALB/c mice subjected to chronic mild stress. | Liu Y et al. | β | 2010 | β |
| Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice. | Lee RS et al. | β | 2010 | β |
| Clinical variations modulate patterns of gene expression and define blood biomarkers in major depression. | Belzeaux R et al. | β | 2010 | β |
| Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances. | Polter A et al. | β | 2010 | β |
| Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures. | Takahashi M et al. | β | 2010 | β |
| Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain. | Xu H et al. | β | 2010 | β |
| Expression analyses of the mitochondrial complex I 75-kDa subunit in early onset schizophrenia and autism spectrum disorder: increased levels as a potential biomarker for early onset schizophrenia. | Taurines R et al. | β | 2010 | β |
| Expression analysis and mutation detection of DLX5 and DLX6 in autism. | Nakashima N et al. | β | 2010 | β |
| Gene expression studies in major depression. | Mehta D et al. | β | 2010 | β |
| Increased peripheral blood expression of electron transport chain genes in bipolar depression. | Beech RD et al. | β | 2010 | β |
| Is human blood a good surrogate for brain tissue in transcriptional studies? | Cai C et al. | β | 2010 | β |
| Network analysis of positional candidate genes of schizophrenia highlights...more than... myelin-related pathways. | Guilloux JP et al. | β | 2010 | β |
| Pilot study: peripheral biomarkers for diagnosing sporadic Parkinson's disease. | GrΓΌnblatt E et al. | β | 2010 | β |
| Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood. | Bousman CA et al. | β | 2010 | β |
| Preliminary evidence of ubiquitin proteasome system dysregulation in schizophrenia and bipolar disorder: convergent pathway analysis findings from two independent samples. | Bousman CA et al. | β | 2010 | β |
| Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment. | Cattaneo A et al. | β | 2010 | β |
| Suggestive evidence for a new locus for epilepsy with heterogeneous phenotypes on chromosome 17q. | SirΓ©n A et al. | β | 2010 | β |
| The effects of globin on microarray-based gene expression analysis of mouse blood. | Winn ME et al. | β | 2010 | β |
| The expression of VGF is reduced in leukocytes of depressed patients and it is restored by effective antidepressant treatment. | Cattaneo A et al. | β | 2010 | β |
| A case-control association study and family-based expression analysis of the bipolar disorder candidate gene PI4K2B. | Houlihan LM et al. | β | 2009 | β |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | β | 2009 | β |
| Alternatively Spliced Genes as Biomarkers for Schizophrenia, Bipolar Disorder and Psychosis: A Blood-Based Spliceome-Profiling Exploratory Study. | Glatt SJ et al. | β | 2009 | β |
| Biomarkers for evaluation of clinical efficacy of multipotential neuroprotective drugs for Alzheimer's and Parkinson's diseases. | Halperin I et al. | β | 2009 | β |
| Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures. | Gavin DP et al. | β | 2009 | β |
| Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation. | Martin MV et al. | β | 2009 | β |
| Gene expression in peripheral blood leukocytes in monozygotic twins discordant for chronic fatigue: no evidence of a biomarker. | Byrnes A et al. | β | 2009 | β |
| Gene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders: evidence for circadian rhythm dysfunction in severe autism. | Hu VW et al. | β | 2009 | β |
| Gene expression profiling of lymphoblasts from autistic and nonaffected sib pairs: altered pathways in neuronal development and steroid biosynthesis. | Hu VW et al. | β | 2009 | β |
| Genetics of stroke. | Fornage M | β | 2009 | β |
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