Association of the muscarinic cholinergic 2 receptor (CHRM2) gene with major depression in women.
paper
Cited
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- Authors
- Comings, David E; Wu, Sujihan; Rostamkhani, M; McGue, Matt; Iacono, William G; MacMurray, James P
- Year
- 2002
- Journal
- American journal of medical genetics
- PMID
- 12116189
- DOI
- 10.1002/ajmg.10406
Cholinergic neurons have been implicated in depression and in the disorders of REM sleep in depression. We examined a common A-> T 1890 polymorphism in the 3' UTR of the cholinergic muscarinic receptor 2 (CHRM2) gene. There was a significant increase in the frequency of 11 homozygotes in 126 women with major depression (43.7%) compared to 304 women without major depression (25.7%), P =.001. There was no increase in the frequency of 11 homozygotes in 52 men with depression (26.9%) compared to 278 men without depression (27.7%). Regression analysis, scoring subjects with the 11 genotype as 1, and those with other genotypes as 0, showed that in women r(2) =.030, F = 13.37, P =.0003. By contrast, in men r(2) =.00001, F = 0.002, P =.96. These results are consistent with a gender-specific role of the CHRM2 gene in depression in women.
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