Netherlands Twin Register: from twins to twin families.
paper
Cited
Public
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- Authors
- Boomsma, Dorret I; de Geus, Eco J C; Vink, Jacqueline M; Stubbe, Janine H; Distel, Marijn A; Hottenga, Jouke-Jan; Posthuma, Danielle; van Beijsterveldt, Toos C E M; Hudziak, James J; Bartels, Meike; Willemsen, Gonneke
- Year
- 2006
- Journal
- Twin research and human genetics : the official journal of the International Society for Twin Studies
- PMID
- 17254420
- DOI
- 10.1375/183242706779462426
In the late 1980s The Netherlands Twin Register (NTR) was established by recruiting young twins and multiples at birth and by approaching adolescent and young adult twins through city councils. The Adult NTR (ANTR) includes twins, their parents, siblings, spouses and their adult offspring. The number of participants in the ANTR who take part in survey and / or laboratory studies is over 22,000 subjects. A special group of participants consists of sisters who are mothers of twins. In the Young NTR (YNTR), data on more than 50,000 young twins have been collected. Currently we are extending the YNTR by including siblings of twins. Participants in YNTR and ANTR have been phenotyped every 2 to 3 years in longitudinal survey studies, since 1986 and 1991 for the YNTR and ANTR, respectively. The resulting large population-based datasets are used for genetic epidemiological studies and also, for example, to advance phenotyping through the development of new syndrome scales based on existing items from other inventories. New research developments further include brain imaging studies in selected and unselected groups, clinical assessment of psychopathology through interviews, and cross-referencing the NTR database to other national databases. A large biobank enterprise is ongoing in the ANTR in which blood and urine samples are collected for genotyping, expression analysis, and metabolomics studies. In this paper we give an update on the YNTR and ANTR phenotyping and on the ongoing ANTR biobank studies.
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| A twin-singleton comparison of developmental trajectories of externalizing and internalizing problems in 6- to 12-year-old children. | Robbers SC et al. | β | 2010 | β |
| Bivariate genetic analyses of stuttering and nonfluency in a large sample of 5-year-old twins. | van Beijsterveldt CE et al. | β | 2010 | β |
| Body composition, smoking, and spontaneous dizygotic twinning. | Hoekstra C et al. | β | 2010 | β |
| Body size of twins compared with siblings and the general population: from birth to late adolescence. | Estourgie-van Burk GF et al. | β | 2010 | β |
| Brain activation during cognitive planning in twins discordant or concordant for obsessive-compulsive symptoms. | den Braber A et al. | β | 2010 | β |
| Effects of gestational age and birth weight on brain volumes in healthy 9 year-old children. | van Soelen ILC et al. | β | 2010 | β |
| Familial resemblance for loneliness. | Distel MA et al. | β | 2010 | β |
| Genetic association in multivariate phenotypic data: power in five models. | Minica CC et al. | β | 2010 | β |
| Genetic covariance structure of the four main features of borderline personality disorder. | Distel MA et al. | β | 2010 | β |
| Genetic epidemiology of attention deficit hyperactivity disorder (ADHD index) in adults. | Boomsma DI et al. | β | 2010 | β |
| Genetic influence demonstrated for MEG-recorded somatosensory evoked responses. | Van 't Ent D et al. | β | 2010 | β |
| Genetic influences on 'environmental' factors. | Vinkhuyzen AA et al. | β | 2010 | β |
| Genetic Influences on Individual Differences in Exercise Behavior during Adolescence. | van der Aa N et al. | β | 2010 | β |
| Genome-wide association studies and the genetics of entrepreneurship. | van der Loos MJ et al. | β | 2010 | β |
| Genome-wide association study of suicide attempts in mood disorder patients. | Perlis RH et al. | β | 2010 | β |
| Heritability and genome-wide linkage scan of subjective happiness. | Bartels M et al. | β | 2010 | β |
| Heritability of anxious-depressive and withdrawn behavior: age-related changes during adolescence. | Lamb DJ et al. | β | 2010 | β |
| Heritability of cannabis initiation in Dutch adult twins. | Vink JM et al. | β | 2010 | β |
| Heritability of DTI and MTR in nine-year-old children. | Brouwer RM et al. | β | 2010 | β |
| HPG-axis hormones during puberty: a study on the association with hypothalamic and pituitary volumes. | Peper JS et al. | β | 2010 | β |
| Individual differences in processing speed and working memory speed as assessed with the Sternberg memory scanning task. | Vinkhuyzen AA et al. | β | 2010 | β |
| Long term costs and effects of reducing the number of twin pregnancies in IVF by single embryo transfer: the TwinSing study. | van Heesch MM et al. | β | 2010 | β |
| Migraine symptomatology and major depressive disorder. | Ligthart L et al. | β | 2010 | β |
| Moderation of genetic factors by parental divorce in adolescents' evaluations of family functioning and subjective wellbeing. | van der Aa N et al. | β | 2010 | β |
| New concepts of biobanks--strategic chance for uro-oncology. | Goebell PJ et al. | β | 2010 | β |
| Secular trends in gestational age and birthweight in twins. | Gielen M et al. | β | 2010 | β |
| The association of mitochondrial content with prevalent and incident type 2 diabetes. | Reiling E et al. | β | 2010 | β |
| The heritability of general cognitive ability increases linearly from childhood to young adulthood. | Haworth CM et al. | β | 2010 | β |
| The Netherlands Twin Register biobank: a resource for genetic epidemiological studies. | Willemsen G et al. | β | 2010 | β |
| The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms. | Middeldorp CM et al. | β | 2010 | β |
| Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology. | Talens RP et al. | β | 2010 | β |
| A genetic analysis of coffee consumption in a sample of Dutch twins. | Vink JM et al. | β | 2009 | β |
| A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. | Estrada K et al. | β | 2009 | β |
| Anesthesia and cognitive performance in children: no evidence for a causal relationship. | Bartels M et al. | β | 2009 | β |
| Association and interaction analyses of eight genes under asthma linkage peaks. | Ferreira MA et al. | β | 2009 | β |
| A twin study of the genetics of high cognitive ability selected from 11,000 twin pairs in six studies from four countries. | Haworth CM et al. | β | 2009 | β |
| Born to be happy? The etiology of subjective well-being. | Bartels M et al. | β | 2009 | β |
| Breastfeeding, maternal education and cognitive function: a prospective study in twins. | Bartels M et al. | β | 2009 | β |
| Familial resemblance of borderline personality disorder features: genetic or cultural transmission? | Distel MA et al. | β | 2009 | β |
| Gamma frailty model for linkage analysis with application to interval-censored migraine data. | Jonker MA et al. | β | 2009 | β |
| Genetic architecture of verbal abilities in children and adolescents. | Hoekstra RA et al. | β | 2009 | β |
| Genetic covariance structure of reading, intelligence and memory in children. | van Leeuwen M et al. | β | 2009 | β |
| Genetic factors underlie stability of obsessive-compulsive symptoms. | van Grootheest DS et al. | β | 2009 | β |
| Genetic influences on the insulin response of the beta cell to different secretagogues. | Simonis-Bik AM et al. | β | 2009 | β |
| Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. | Sullivan PF et al. | β | 2009 | β |
| Genome-wide association study of exercise behavior in Dutch and American adults. | De Moor MH et al. | β | 2009 | β |
| Genome-wide association study of smoking initiation and current smoking. | Vink JM et al. | β | 2009 | β |
| Heritability of regional and global brain structure at the onset of puberty: a magnetic resonance imaging study in 9-year-old twin pairs. | Peper JS et al. | β | 2009 | β |
| Heritability of testis size. | Estourgie-van Burk GF et al. | β | 2009 | β |
| Latent class analysis of the Child Behavior Checklist Obsessive-Compulsive Scale. | Althoff RR et al. | β | 2009 | β |
| Maternal ratings of attention problems in ADHD: evidence for the existence of a continuum. | Lubke GH et al. | β | 2009 | β |
| Predictors of problem drinking in adolescence and young adulthood. A longitudinal twin-family study. | Poelen EA et al. | β | 2009 | β |
| Prevalence of polycystic ovary syndrome in women from opposite-sex twin pairs. | Kuijper EA et al. | β | 2009 | β |
| Sex differences in sum scores may be hard to interpret: the importance of measurement invariance. | Slof-Op 't Landt MC et al. | β | 2009 | β |
| Similarities in drinking behavior of twin's friends: moderation of heritability of alcohol use. | Poelen EA et al. | β | 2009 | β |
| The estimated probability of dizygotic twins: a comparison of two methods. | Hardin J et al. | β | 2009 | β |
| The five-factor model of personality and borderline personality disorder: a genetic analysis of comorbidity. | Distel MA et al. | β | 2009 | β |
| The heritability of aptitude and exceptional talent across different domains in adolescents and young adults. | Vinkhuyzen AA et al. | β | 2009 | β |
| A comparison of early and late respondents in a twin-family survey study. | Vink JM et al. | β | 2008 | β |
| A genome-wide linkage scan for age at menarche in three populations of European descent. | Anderson CA et al. | β | 2008 | β |
| A genome-wide linkage scan provides evidence for both new and previously reported loci influencing common migraine. | Ligthart L et al. | β | 2008 | β |
| An exploration of gene-environment interaction and asthma in a large sample of 5-year-old Dutch twins. | van Beijsterveldt TC et al. | β | 2008 | β |
| Asthma and mode of birth delivery: a study in 5-year-old Dutch twins. | van Beijsterveldt TC et al. | β | 2008 | β |
| Catechol O-methyl transferase and dopamine D2 receptor gene polymorphisms: evidence of positive heterosis and gene-gene interaction on working memory functioning. | Gosso MF et al. | β | 2008 | β |
| Cerebral white matter in early puberty is associated with luteinizing hormone concentrations. | Peper JS et al. | β | 2008 | β |
| Chromosome 9: linkage for borderline personality disorder features. | Distel MA et al. | β | 2008 | β |
| Common variants underlying cognitive ability: further evidence for association between the SNAP-25 gene and cognition using a family-based study in two independent Dutch cohorts. | Gosso MF et al. | β | 2008 | β |
| Design and implementation of a twin-family database for behavior genetics and genomics studies. | Boomsma DI et al. | β | 2008 | β |
| Empirical data about women's attitudes towards a hypothetical pediatric biobank. | Neidich AB et al. | β | 2008 | β |
| Evaluation of HapMap data in six populations of European descent. | Lundmark PE et al. | β | 2008 | β |
| Familial twinning and fertility in Dutch mothers of twins. | Hoekstra C et al. | β | 2008 | β |
| Gene-environment interaction in adults' IQ scores: measures of past and present environment. | van der Sluis S et al. | β | 2008 | β |
| Genetic and environmental contributions to self-report obsessive-compulsive symptoms in Dutch adolescents at ages 12, 14, and 16. | van Grootheest DS et al. | β | 2008 | β |
| Genetic and environmental contributions to stability in loneliness throughout childhood. | Bartels M et al. | β | 2008 | β |
| Genetic and environmental influences on the relation between attention problems and attention deficit hyperactivity disorder. | Derks EM et al. | β | 2008 | β |
| Genetic and environmental influences on the stability of withdrawn behavior in children: a longitudinal, multi-informant twin study. | Hoekstra RA et al. | β | 2008 | β |
| Genetic influences on disordered eating behaviour are largely independent of body mass index. | Slof-Op 't Landt MC et al. | β | 2008 | β |
| Genetic influences on the difference in variability of height, weight and body mass index between Caucasian and East Asian adolescent twins. | Hur YM et al. | β | 2008 | β |
| Genetic influences on thought problems in 7-year-olds: a twin-study of genetic, environmental and rater effects. | Abdellaoui A et al. | β | 2008 | β |
| Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects. | Boomsma DI et al. | β | 2008 | β |
| Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands. | Wray NR et al. | β | 2008 | β |
| Growth references for height, weight and body mass index of twins aged 0-2.5 years. | van Dommelen P et al. | β | 2008 | β |
| Heritability of borderline personality disorder features is similar across three countries. | Distel MA et al. | β | 2008 | β |
| Heritability of parturition timing: an extended twin design analysis. | Kistka ZA et al. | β | 2008 | β |
| Heritability of self-reported asthma and allergy: a study in adult Dutch twins, siblings and parents. | Willemsen G et al. | β | 2008 | β |
| Heritability of self-reported phobic fear. | Distel MA et al. | β | 2008 | β |
| Life events, anxious depression and personality: a prospective and genetic study. | Middeldorp CM et al. | β | 2008 | β |
| Males do not reduce the fitness of their female co-twins in contemporary samples. | Medland SE et al. | β | 2008 | β |
| Marital resemblance for obsessive-compulsive, anxious and depressive symptoms in a population-based sample. | van Grootheest DS et al. | β | 2008 | β |
| Mode of conception of twin pregnancies: willingness to reply to survey items and comparison of survey data to hospital records. | van Beijsterveldt CE et al. | β | 2008 | β |
| Personality trait similarity between spouses in four cultures. | McCrae RR et al. | β | 2008 | β |
| Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles. | Bruder CE et al. | β | 2008 | β |
| Similarities and differences in lipidomics profiles among healthy monozygotic twin pairs. | Draisma HH et al. | β | 2008 | β |
| Sleep during a regular week night: a twin-sibling study. | Boomsma DI et al. | β | 2008 | β |
| The heritability of HbA1c and fasting blood glucose in different measurement settings. | Simonis-Bik AM et al. | β | 2008 | β |
| The relative contribution of genes and environment to alcohol use in early adolescents: are similar factors related to initiation of alcohol use and frequency of drinking? | Poelen EA et al. | β | 2008 | β |
| Vitamin D receptor gene polymorphisms have negligible effect on human height. | Macgregor S et al. | β | 2008 | β |
| Assessment and etiology of attention deficit hyperactivity disorder and oppositional defiant disorder in boys and girls. | Derks EM et al. | β | 2007 | β |
| Assessment of motor milestones in twins. | Langendonk JM et al. | β | 2007 | β |
| Exploring the functional role of the CHRM2 gene in human cognition: results from a dense genotyping and brain expression study. | Gosso FM et al. | β | 2007 | β |
| Genetically informative designs in the study of resilience in developmental psychopathology. | Bartels M et al. | β | 2007 | β |
| Genetic and environmental covariation between autistic traits and behavioral problems. | Hoekstra RA et al. | β | 2007 | β |
| Genetic and environmental influences on obsessive-compulsive symptoms in adults: a population-based twin-family study. | Van Grootheest DS et al. | β | 2007 | β |
| Genome-wide linkage scan for exercise participation in Dutch sibling pairs. | De Moor MH et al. | β | 2007 | β |
| Heritability of body mass index: a comparison between the Netherlands and Spain. | OrdoΓ±ana JR et al. | β | 2007 | β |
| Longitudinal genetic analysis for loneliness in Dutch twins. | Boomsma DI et al. | β | 2007 | β |
| Personality differences in monozygotic twins discordant for cannabis use. | Vink JM et al. | β | 2007 | β |
| Personality, health and lifestyle in a questionnaire family study: a comparison between highly cooperative and less cooperative families. | Distel MA et al. | β | 2007 | β |
| Religious upbringing and neuroticism in Dutch twin families. | Willemsen G et al. | β | 2007 | β |
| Young Netherlands Twin Register (Y-NTR): a longitudinal multiple informant study of problem behavior. | Bartels M et al. | β | 2007 | β |