Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence.
paper
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- Authors
- Schmidt, Lutz G; Samochowiec, Jerzy; Finckh, Ulrich; Fiszer-Piosik, Ewa; Horodnicki, Jan; Wendel, B; Rommelspacher, Hans; Hoehe, Margret R
- Year
- 2002
- Journal
- Drug and alcohol dependence
- PMID
- 11841893
- DOI
- 10.1016/s0376-8716(01)00164-8
Due to the involvement of the endogenous cannabinoid system in brain reward mechanisms a silent polymorphism (1359G/A; Thr453Thr) in the single coding exon of the CB1 human cannabinoid receptor gene (CNR1) was analysed in 121 severely affected Caucasian alcoholics and 136 most likely non-alcoholic controls. The observed frequency of the A allele was 31.2% for controls and 42.1% for alcoholics with severe withdrawal syndromes (P=0.010). Post-hoc exploration indicated that this allelic association resulted from an excess of the homozygous A/A genotype in patients with a history of alcohol delirium (P=0.031, DF 2), suggesting s an increased risk of delirium (OR=2.45, 95% CI 1.14--5.25). This finding suggests that the homozygous genotype CNR1 1359A/A confers vulnerability to alcohol withdrawal delirium.
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|---|---|---|---|---|
| Modulating the endocannabinoid system in alcohol use disorder: A translational systematic review and meta-analysis of preclinical and human studies. | Costa GPA et al. | — | 2026 | → |
| G protein-coupled receptor (GPCR) pharmacogenomics. | Thompson MD et al. | — | 2024 | → |
| Cannabis Pharmacogenomics: A Path to Personalized Medicine. | Babayeva M et al. | — | 2023 | → |
| Biomarkers of the Endocannabinoid System in Substance Use Disorders. | Navarrete F et al. | — | 2022 | → |
| Molecular Alterations of the Endocannabinoid System in Psychiatric Disorders. | Navarro D et al. | — | 2022 | → |
| The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use. | Bornscheuer L et al. | — | 2022 | → |
| Associations of CB1 cannabinoid receptor (CNR1) gene polymorphisms with risk for alcohol dependence: Evidence from meta-analyses of genetic and genome-wide association studies. | Pabalan N et al. | — | 2021 | → |
| A systems omics-based approach to decode substance use disorders and neuroadaptations. | Veerappa A et al. | — | 2021 | → |
| Endocannabinoid Gene × Gene Interaction Association to Alcohol Use Disorder in Two Adolescent Cohorts. | Elkrief L et al. | — | 2021 | → |
| Influence of Cannabinoid Receptor 1 Genetic Variants on the Subjective Effects of Smoked Cannabis. | Murphy T et al. | — | 2021 | → |
| On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors. | Pucci M et al. | — | 2021 | → |
| Acetylcholine Muscarinic M<sub>4</sub> Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents. | Walker LC et al. | — | 2020 | → |
| GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. | Neasta J et al. | — | 2020 | → |
| Distinct functions of endogenous cannabinoid system in alcohol abuse disorders. | Basavarajappa BS et al. | — | 2019 | → |
| Endocannabinoid System and Alcohol Abuse Disorders. | Basavarajappa BS | — | 2019 | → |
| Genetic and Environmental Risk Factors for Cannabis Use: Preliminary Results for the Role of Parental Care Perception. | Gerra MC et al. | — | 2019 | → |
| Priority Considerations for Medicinal Cannabis-Related Research. | Bonn-Miller MO et al. | — | 2019 | → |
| Acupuncture on the Stress-Related Drug Relapse to Seeking. | Roh HS et al. | — | 2018 | → |
| Can Your DNA Influence Your Bet-Placing? The Impact of Cannabinoid Receptor 1 Gene on Gambling Tasks. | Qin H et al. | — | 2018 | → |
| Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice. | Helfand AI et al. | — | 2017 | → |
| Chronic alcohol exposure disrupts CB<sub>1</sub> regulation of GABAergic transmission in the rat basolateral amygdala. | Varodayan FP et al. | — | 2017 | → |
| The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data. | Gouvêa ES et al. | — | 2017 | → |
| Cannabinoid CB1 receptor inhibition blunts adolescent-typical increased binge alcohol and sucrose consumption in male C57BL/6J mice. | Agoglia AE et al. | — | 2016 | → |
| Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families. | Hill SY et al. | — | 2016 | → |
| Roles for the endocannabinoid system in ethanol-motivated behavior. | Henderson-Redmond AN et al. | — | 2016 | → |
| Altered CB1 receptor coupling to G-proteins in the post-mortem caudate nucleus and cerebellum of alcoholic subjects. | Erdozain AM et al. | — | 2015 | → |
| Endocannabinoid signalling in reward and addiction. | Parsons LH et al. | — | 2015 | → |
| Role of CNR1 polymorphisms in moderating the effects of psychosocial adversity on impulsivity in adolescents. | Buchmann AF et al. | — | 2015 | → |
| The endocannabinoid system is altered in the post-mortem prefrontal cortex of alcoholic subjects. | Erdozain AM et al. | — | 2015 | → |
| Pharmacogenetics of the G protein-coupled receptors. | Thompson MD et al. | — | 2014 | → |
| Evidence for the involvement of cannabinoid receptors' polymorphisms in the pathophysiology of human diseases. | Vasileiou I et al. | — | 2013 | → |
| A review of the interactions between alcohol and the endocannabinoid system: implications for alcohol dependence and future directions for research. | Pava MJ et al. | — | 2012 | → |
| Cannabinoid receptor 1 gene is associated with alcohol dependence. | Marcos M et al. | — | 2012 | → |
| Cannabinoid type 1 receptor gene polymorphism and macronutrient intake. | Caruso MG et al. | — | 2012 | → |
| Differential effects of single versus repeated alcohol withdrawal on the expression of endocannabinoid system-related genes in the rat amygdala. | Serrano A et al. | — | 2012 | → |
| Electroacupuncture inhibits CB1 upregulation induced by ethanol withdrawal in mice. | Escosteguy-Neto JC et al. | — | 2012 | → |
| Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. | Wang KS et al. | — | 2012 | → |
| Neurobiology of consummatory behavior: mechanisms underlying overeating and drug use. | Barson JR et al. | — | 2012 | → |
| The genetic basis of the endocannabinoid system and drug addiction in humans. | López-Moreno JA et al. | — | 2012 | → |
| The genetics of substance dependence. | Wang JC et al. | — | 2012 | → |
| ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. | Chen J et al. | — | 2011 | → |
| Association Study of Two Cannabinoid Receptor Genes, CNR1 and CNR2, with Methamphetamine Dependence. | Okahisa Y et al. | — | 2011 | → |
| Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia. | Ho BC et al. | — | 2011 | → |
| CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis. | Benyamina A et al. | — | 2011 | → |
| Critical thoughts on current rodent models for evaluating potential treatments of alcohol addiction and withdrawal. | Ripley TL et al. | — | 2011 | → |
| Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors. | Serrano A et al. | — | 2011 | → |
| Involvement of the endocannabinoid system in alcohol dependence: the biochemical, behavioral and genetic evidence. | Erdozain AM et al. | — | 2011 | → |
| Neurochemical basis of cannabis addiction. | Maldonado R et al. | — | 2011 | → |
| Psychopharmacological comparison of schizophrenia spectrum disorder with and without cannabis dependency. | Makkos Z et al. | — | 2011 | → |
| Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1. | Proudnikov D et al. | — | 2010 | → |
| Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain. | Monteleone P et al. | — | 2010 | → |
| Individual and additive effects of the CNR1 and FAAH genes on brain response to marijuana cues. | Filbey FM et al. | — | 2010 | → |
| Interaction of SLC6A4 and DRD2 polymorphisms is associated with a history of delirium tremens. | Karpyak VM et al. | — | 2010 | → |
| Selective alterations of the CB1 receptors and the fatty acid amide hydrolase in the ventral striatum of alcoholics and suicides. | Vinod KY et al. | — | 2010 | → |
| The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease. | Storr M et al. | — | 2010 | → |
| The G1359A-CNR1 gene polymorphism is associated to glioma in Spanish patients. | Núñez M et al. | — | 2010 | → |
| Vulnerability Factors for the Psychiatric and Behavioral Effects of Cannabis. | Bortolato M et al. | — | 2010 | → |
| Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects. | Monteleone P et al. | — | 2009 | → |
| Candidate genes for cannabis use disorders: findings, challenges and directions. | Agrawal A et al. | — | 2009 | → |
| Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications. | Onaivi ES | — | 2009 | → |
| Cannabis and psychosis/schizophrenia: human studies. | D'Souza DC et al. | — | 2009 | → |
| Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample. | Zuo L et al. | — | 2009 | → |
| The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults. | Hartman CA et al. | — | 2009 | → |
| The genetics of deliria. | Adamis D et al. | — | 2009 | → |
| Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder. | Lu AT et al. | — | 2008 | → |
| Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression. | Domschke K et al. | — | 2008 | → |
| Cannabinoid receptor 1 gene association with nicotine dependence. | Chen X et al. | — | 2008 | → |
| CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. | Rubio M et al. | — | 2008 | → |
| Gene expression of opioid and dopamine systems in mouse striatum: effects of CB1 receptors, age and sex. | Gerald TM et al. | — | 2008 | → |
| Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice. | Vinod KY et al. | — | 2008 | → |
| Large-scale molecular analysis of a 34 Mb interval on chromosome 6q: major refinement of the RP25 interval. | Abd El-Aziz MM et al. | — | 2008 | → |
| Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanol. | Vinod KY et al. | — | 2008 | → |
| Non-mammalian vertebrate models and the endocannabinoid system: relationships with gonadotropin-releasing hormone. | Chianese R et al. | — | 2008 | → |
| Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis. | Woolmore J et al. | — | 2008 | → |
| The CNR1 gene as a pharmacogenetic factor for antipsychotics rather than a susceptibility gene for schizophrenia. | Hamdani N et al. | — | 2008 | → |
| The endocannabinoid system: a new molecular target for the treatment of tobacco addiction. | Scherma M et al. | — | 2008 | → |
| The incentive salience of alcohol: translating the effects of genetic variant in CNR1. | Hutchison KE et al. | — | 2008 | → |
| Association between cannabinoid type-1 receptor polymorphism and body mass index in a southern Italian population. | Gazzerro P et al. | — | 2007 | → |
| Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians. | Ehlers CL et al. | — | 2007 | → |
| Association in alcoholic patients between psychopathic traits and the additive effect of allelic forms of the CNR1 and FAAH endocannabinoid genes, and the 3' region of the DRD2 gene. | Hoenicka J et al. | — | 2007 | → |
| CNR1 variation modulates risk for drug and alcohol dependence. | Zuo L et al. | — | 2007 | → |
| Do motor control genes contribute to interindividual variability in decreased movement in patients with pain? | Mishra BK et al. | — | 2007 | → |
| Endocannabinoids and the regulation of their levels in health and disease. | Di Marzo V et al. | — | 2007 | → |
| Gene-alcohol interactions in the metabolic syndrome. | Corella D | — | 2007 | → |
| Genetic polymorphisms of the endocannabinoid system. | Norrod AG et al. | — | 2007 | → |
| Genetic polymorphisms related to delirium tremens: a systematic review. | van Munster BC et al. | — | 2007 | → |
| Genetic variation and shared biological susceptibility underlying comorbidity in neuropsychiatry. | Palomo T et al. | — | 2007 | → |
| No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents. | Müller TD et al. | — | 2007 | → |
| Polymorphisms of the dopamine D4 receptor gene (DRD4 VNTR) and cannabinoid CB1 receptor gene (CNR1) are not strongly related to cue-reactivity after alcohol exposure. | van den Wildenberg E et al. | — | 2007 | → |
| Regulation of brain anandamide by acute administration of ethanol. | Ferrer B et al. | — | 2007 | → |
| The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABA(A) receptors after chronic ethanol exposure. | Warnault V et al. | — | 2007 | → |
| (AAT)n repeat in the cannabinoid receptor gene, CNR1: association with schizophrenia in a Spanish population. | Martínez-Gras I et al. | — | 2006 | → |
| Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents. | Hopfer CJ et al. | — | 2006 | → |
| Analysis of the endocannabinoid system by using CB1 cannabinoid receptor knockout mice. | Valverde O et al. | — | 2005 | → |
| A role for cannabinoid CB1 receptors in mood and anxiety disorders. | Witkin JM et al. | — | 2005 | → |
| Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats. | Cippitelli A et al. | — | 2005 | → |
| CB1 receptor knockout mice display reduced ethanol-induced conditioned place preference and increased striatal dopamine D2 receptors. | Houchi H et al. | — | 2005 | → |
| Depression in Parkinson's disease is related to a genetic polymorphism of the cannabinoid receptor gene (CNR1). | Barrero FJ et al. | — | 2005 | → |
| Detection of alcohol consumption in suicides. | Schneider B et al. | — | 2005 | → |
| Ethanol self-administration and ethanol conditioned place preference are reduced in mice lacking cannabinoid CB1 receptors. | Thanos PK et al. | — | 2005 | → |
| Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. | Kreek MJ et al. | — | 2005 | → |
| The endocannabinoid system: physiology and pharmacology. | Rodríguez de Fonseca F et al. | — | 2005 | → |
| Changes in endocannabinoid contents in reward-related brain regions of alcohol-exposed rats, and their possible relevance to alcohol relapse. | González S et al. | — | 2004 | → |
| Effects of marijuana on neurophysiological signals of working and episodic memory. | Ilan AB et al. | — | 2004 | → |
| Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse. | Zhang PW et al. | — | 2004 | → |
| SR147778 [5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a new potent and selective antagonist of the CB1 cannabinoid receptor: biochemical and pharmacological characterization. | Rinaldi-Carmona M et al. | — | 2004 | → |
| A critical role for the cannabinoid CB1 receptors in alcohol dependence and stress-stimulated ethanol drinking. | Racz I et al. | — | 2003 | → |
| A missense mutation in human fatty acid amide hydrolase associated with problem drug use. | Sipe JC et al. | — | 2002 | → |