A hospital-based twin register of the heritability of DSM-IV unipolar depression.
paper
Cited
Public
Unavailable
- Authors
- McGuffin, P; Katz, R; Watkins, S; Rutherford, J
- Year
- 1996
- Journal
- Archives of general psychiatry
- PMID
- 8629888
- DOI
- 10.1001/archpsyc.1996.01830020047006
OBJECTIVES: To estimate the contribution of genes and shared family environment to the liability to DSM-IV major depression and to examine the influence of certain proband characteristics on twin concordance. METHODS: We studied 177 probands with major depressive disorder ascertained via the Maudsley Hospital Twin Register (London, England) and their same-sex co-twins. Diagnostic assessments were carried out blind to zygosity and information on the other member of the twin pair. Probandwise concordances were used to compute correlations in liability, and model fitting was performed using maximum likelihood procedures. RESULTS: The probandwise concordance was 46% in monozygotic (n = 68) and 20% in dizygotic (n = 109) twins, a statistically highly significant difference. There was no evidence of a sex difference in heritability or of shared environmental effects. Depending on the assumed population risks for DSM-IV, major depression estimates of heritability were between 48% and 75%. A duration of longest episode of less than 13 months, multiple episodes, and an endogenous rather than neurotic pattern of symptoms as established by the International Classification of Diseases, Ninth Revision, in the proband were associated with a trend toward a higher monozygotic-dizygotic concordance ratio. Using log-linear analysis, only the association between duration of episodes and monozygotic-dizygotic concordance ratio was significant. CONCLUSIONS: Liability to DSM-IV major depression has a substantial heritable component, and there is no evidence of an effect of shared family environment. Some proband characteristics, especially shorter duration of episodes, may be associated with a larger degree of genetic determination.
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| Monozygotic twins discordant for depression: An extended network comparison of depressive symptoms, cognitive functions and daily activities. | Moron M et al. | — | 2024 | → |
| Polygenic liabilities and treatment trajectories in early-onset depression: a Danish register-based study. | Mundy J et al. | — | 2024 | → |
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| The genetic basis of major depressive disorder. | Flint J | — | 2023 | → |
| Mental Health Symptom Reduction Using Digital Therapeutics Care Informed by Genomic SNPs and Gut Microbiome Signatures. | Pedroso I et al. | — | 2022 | → |
| Exploring the genetic heterogeneity in major depression across diagnostic criteria. | Jermy BS et al. | — | 2021 | → |
| Preventive psychiatry: a blueprint for improving the mental health of young people. | Fusar-Poli P et al. | — | 2021 | → |
| Risk and protective factors for mental disorders beyond genetics: an evidence-based atlas. | Arango C et al. | — | 2021 | → |
| Adults with Autism and Adults with Depression Show Similar Attentional Biases to Social-Affective Images. | Unruh KE et al. | — | 2020 | → |
| A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits. | Dahl A et al. | — | 2020 | → |
| Discovery of the Environmental Factors Affecting Urban Dwellers' Mental Health: A Data-Driven Approach. | Wu C et al. | — | 2020 | → |
| Evolutionary Ecological Model of Defence Activation Disorders Via the Marginal Value Theorem. | Park H | — | 2020 | → |
| Polygenic Influences on Pubertal Timing and Tempo and Depressive Symptoms in Boys and Girls. | Horvath G et al. | — | 2020 | → |
| Recent advances with 5-HT<sub>3</sub> modulators for neuropsychiatric and gastrointestinal disorders. | Juza R et al. | — | 2020 | → |
| SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex. | Lei Y et al. | — | 2020 | → |
| Advance in Stress for Depressive Disorder. | Ding Y et al. | — | 2019 | → |
| BDNF and COMT, but not APOE, alleles are associated with psychiatric symptoms in refractory epilepsy. | Doherty C et al. | — | 2019 | → |
| Is aberrant affective cognition an endophenotype for affective disorders? - A monozygotic twin study. | Meluken I et al. | — | 2019 | → |
| Network Analysis of Depression-Related Transcriptomic Profiles. | Miao X et al. | — | 2019 | → |
| Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder. | Trzaskowski M et al. | — | 2019 | → |
| Childhood physical maltreatment, perceived social isolation, and internalizing symptoms: a longitudinal, three-wave, population-based study. | Sheikh MA | — | 2018 | → |
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | Culverhouse RC et al. | — | 2018 | → |
| Course of recurrent depression in monozygotic twins - A case report. | Vengadavaradan A et al. | — | 2018 | → |
| Epigenetics applied to psychiatry: Clinical opportunities and future challenges. | Kular L et al. | — | 2018 | → |
| Reduced Recovery of Depression in Female T Allele Carriers of <i>TNF-RII</i> rs1061622 at Earlier Stage after Wenchuan Earthquake. | Memon NH et al. | — | 2018 | → |
| The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort. | Piel JH et al. | — | 2018 | → |
| The Genetic Epidemiology of Treated Major Depression in Sweden. | Kendler KS et al. | — | 2018 | → |
| The Genetic Relationship Between Psychological Distress, Somatic Distress, Affective Disorders, and Substance Use in Young Australian Adults: A Multivariate Twin Study. | Chang LH et al. | — | 2018 | → |
| Age of onset and family history as indicators of polygenic risk for major depression. | Docherty AR et al. | — | 2017 | → |
| Altered DLPFC-Hippocampus Connectivity During Working Memory: Independent Replication and Disorder Specificity of a Putative Genetic Risk Phenotype for Schizophrenia. | Schneider M et al. | — | 2017 | → |
| Association of Val66Met polymorphism at brain derived neurotrophic factor gene with depression among Chinese adolescents after Wenchuan earthquake: An 18months longitudinal study. | Fan M et al. | — | 2017 | → |
| Confounding and Statistical Significance of Indirect Effects: Childhood Adversity, Education, Smoking, and Anxious and Depressive Symptomatology. | Sheikh MA | — | 2017 | → |
| Etiology in psychiatry: embracing the reality of poly-gene-environmental causation of mental illness. | Uher R et al. | — | 2017 | → |
| Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. | Rietschel L et al. | — | 2017 | → |
| Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared Spectroscopy (NIRS) Study. | Ohi K et al. | — | 2017 | → |
| Polymorphism of ERK/PTPRR Genes in Major Depressive Disorder at Resting-State Brain Function. | Wang Y et al. | — | 2017 | → |
| The Relationship Between Mental Health, Disease Severity, and Genetic Risk for Depression in Early Rheumatoid Arthritis. | Euesden J et al. | — | 2017 | → |
| The use of behavioural genetics in the criminal justice system: A disability & human rights perspective. | O'Mahony C et al. | — | 2017 | → |
| Epigenetic differences in monozygotic twins discordant for major depressive disorder. | Malki K et al. | — | 2016 | → |
| Familial aggregation and heritability of the melancholic and atypical subtypes of depression. | Lamers F et al. | — | 2016 | → |
| Heritability of major depressive and comorbid anxiety disorders in multi-generational families at high risk for depression. | Guffanti G et al. | — | 2016 | → |
| Phenotypic Association Analyses With Copy Number Variation in Recurrent Depressive Disorder. | Rucker JJ et al. | — | 2016 | → |
| Preliminary assessment of pre-morbid DNA methylation in individuals at high genetic risk of mood disorders. | Walker RM et al. | — | 2016 | → |
| Profiling depression in childhood and adolescence: the role of conduct problems. | Riglin L et al. | — | 2016 | → |
| Puberty, Socioeconomic Status, and Depression in Girls: Evidence for Gene × Environment Interactions. | Mendle J et al. | — | 2016 | → |
| The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders. | Smoller JW | — | 2016 | → |
| TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics. | Gupta M et al. | — | 2016 | → |
| Age of onset and course of major depressive disorder: associations with psychosocial functioning outcomes in adulthood. | Wilson S et al. | — | 2015 | → |
| Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS). | Fernandez-Pujals AM et al. | — | 2015 | → |
| Genetic moderation of interpersonal psychotherapy efficacy for low-income mothers with major depressive disorder: implications for differential susceptibility. | Cicchetti D et al. | — | 2015 | → |
| Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder. | Legge RM et al. | — | 2015 | → |
| The interaction between stress and genetic factors in the etiopathogenesis of depression. | McGuffin P et al. | — | 2015 | → |
| Translating depression biomarkers for improved targeted therapies. | Bredt DS et al. | — | 2015 | → |
| A meta-analysis of the risk of major affective disorder in relatives of individuals affected by major depressive disorder or bipolar disorder. | Wilde A et al. | — | 2014 | → |
| A recessive genetic model and runs of homozygosity in major depressive disorder. | Power RA et al. | — | 2014 | → |
| Association analysis of genes in serotonin pathway with attention and executive function in patients with bipolar affective disorder. | Yang Z et al. | — | 2014 | → |
| Does family history of depression predict major depression in midlife women? Study of Women's Health Across the Nation Mental Health Study (SWAN MHS). | Colvin A et al. | — | 2014 | → |
| Gene-environment interactions in severe mental illness. | Uher R | — | 2014 | → |
| Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population. | Xiang B et al. | — | 2014 | → |
| Genetic and environmental risk for major depression in African-American and European-American women. | Duncan AE et al. | — | 2014 | → |
| Genetic variants in the genes of the stress hormone signalling pathway and depressive symptoms during and after pregnancy. | Schneider M et al. | — | 2014 | → |
| Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. | Davies MN et al. | — | 2014 | → |
| Investigating the genetic variation underlying episodicity in major depressive disorder: suggestive evidence for a bipolar contribution. | Ferentinos P et al. | — | 2014 | → |
| Major depressive disorder in DSM-5: implications for clinical practice and research of changes from DSM-IV. | Uher R et al. | — | 2014 | → |
| Premorbid risk factors for major depressive disorder: are they associated with early onset and recurrent course? | Wilson S et al. | — | 2014 | → |
| The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression. | Okada S et al. | — | 2014 | → |
| A mega-analysis of genome-wide association studies for major depressive disorder. | Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium et al. | — | 2013 | → |
| Body mass index, but not FTO genotype or major depressive disorder, influences brain structure. | Cole JH et al. | — | 2013 | → |
| Contributions of maltreatment and serotonin transporter genotype to depression in childhood, adolescence, and early adulthood. | Cutuli JJ et al. | — | 2013 | → |
| Depression as an evolutionary strategy for defense against infection. | Anders S et al. | — | 2013 | → |
| Duplications in RB1CC1 are associated with schizophrenia; identification in large European sample sets. | Degenhardt F et al. | — | 2013 | → |
| Exploring the intergenerational persistence of mental health: evidence from three generations. | Johnston DW et al. | — | 2013 | → |
| Gene-environment interactions in major depressive disorder. | Klengel T et al. | — | 2013 | → |
| Genome-wide association analysis accounting for environmental factors through propensity-score matching: application to stressful live events in major depressive disorder. | Power RA et al. | — | 2013 | → |
| Genome-wide association analysis of copy number variation in recurrent depressive disorder. | Rucker JJ et al. | — | 2013 | → |
| Glial cell line-derived neurotrophic factor (GDNF) as a novel candidate gene of anxiety. | Kotyuk E et al. | — | 2013 | → |
| Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression. | Culverhouse RC et al. | — | 2013 | → |
| Research review: the role of cytokines in depression in adolescents: a systematic review. | Mills NT et al. | — | 2013 | → |
| Resting-state brain activity in major depressive disorder patients and their siblings. | Liu CH et al. | — | 2013 | → |
| The current state of play on the molecular genetics of depression. | Cohen-Woods S et al. | — | 2013 | → |
| Affective intensity and lability: heritability in adult male twins. | Coccaro EF et al. | — | 2012 | → |
| Association between copy number variants in 16p11.2 and major depressive disorder in a German case-control sample. | Degenhardt F et al. | — | 2012 | → |
| CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease. | Bhat S et al. | — | 2012 | → |
| Clinical predictors of familial depression in Han Chinese women. | Wang L et al. | — | 2012 | → |
| Epilogue: Lessons from the CONVERGE study of major depressive disorder in China. | Flint J et al. | — | 2012 | → |
| Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses. | Visscher PM et al. | — | 2012 | → |
| Gene-environment interaction in major depression and antidepressant treatment response. | Keers R et al. | — | 2012 | → |
| Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. | Wray NR et al. | — | 2012 | → |
| Genomic structural variation in psychiatric disorders. | Rucker JJ et al. | — | 2012 | → |
| High dimensional endophenotype ranking in the search for major depression risk genes. | Glahn DC et al. | — | 2012 | → |
| Using summary data from the danish national registers to estimate heritabilities for schizophrenia, bipolar disorder, and major depressive disorder. | Wray NR et al. | — | 2012 | → |
| A genome-wide significant linkage for severe depression on chromosome 3: the depression network study. | Breen G et al. | — | 2011 | → |
| Common genetic influences on depression, alcohol, and substance use disorders in Mexican-American families. | Olvera RL et al. | — | 2011 | → |
| Community interest in predictive genetic testing for susceptibility to major depressive disorder in a large national sample. | Wilde A et al. | — | 2011 | → |
| Genes, environment, and individual differences in responding to treatment for depression. | Uher R | — | 2011 | → |
| Genome-wide association study of recurrent early-onset major depressive disorder. | Shi J et al. | — | 2011 | → |
| Genomics for disease treatment and prevention. | Bloss CS et al. | — | 2011 | → |
| Profiling the evolution of depression after epilepsy surgery. | Wrench JM et al. | — | 2011 | → |
| Psychiatric 'diseases' versus behavioral disorders and degree of genetic influence. | Bienvenu OJ et al. | — | 2011 | → |
| Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results. | Uher R et al. | — | 2011 | → |
| The representation of early onset depression by ICD-9 and ICD-10 categories. | Sinzig J et al. | — | 2011 | → |
| Gene-environment correlations in the stress-depression relationship. | Schnittker J | — | 2010 | → |
| Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression. | Rietschel M et al. | — | 2010 | → |
| Genome-wide association study of major recurrent depression in the U.K. population. | Lewis CM et al. | — | 2010 | → |
| Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. | Verhagen M et al. | — | 2010 | → |
| Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans. | Dao DT et al. | — | 2010 | → |
| Polymorphisms of genes for brain-derived neurotrophic factor, methylenetetrahydrofolate reductase, tyrosine hydroxylase, and endothelial nitric oxide synthase in depression and metabolic syndrome. | Zeman M et al. | — | 2010 | → |
| Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions. | Roger S et al. | — | 2010 | → |
| Software for generating liability distributions for pedigrees conditional on their observed disease states and covariates. | Campbell DD et al. | — | 2010 | → |
| The genetics of affective disorder and suicide. | McGuffin P et al. | — | 2010 | → |
| The genetics of mood disorders. | Lau JY et al. | — | 2010 | → |
| The relation between eating- and weight-related disturbances and depression in adolescence: a review. | Rawana JS et al. | — | 2010 | → |
| The role of adolescent attachment in moderating and mediating the links between parent and adolescent psychological symptoms. | Woodhouse SS et al. | — | 2010 | → |
| Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression. | Kloiber S et al. | — | 2010 | → |
| Vascular endothelial growth factor (VEGF) polymorphism is associated with treatment resistant depression. | Viikki M et al. | — | 2010 | → |
| An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population. | Wang S et al. | — | 2009 | → |
| Disruption of the circadian timing systems: molecular mechanisms in mood disorders. | Mendlewicz J | — | 2009 | → |
| Familiality of depression in the community; associations with gender and phenotype of major depressive disorder. | Janzing JG et al. | — | 2009 | → |
| Genetic and environmental contributions to depression in Sri Lanka. | Ball HA et al. | — | 2009 | → |
| Genome scan in sibling pairs with juvenile-onset mood disorders: Evidence for linkage to 13q and Xq. | Wigg K et al. | — | 2009 | → |
| Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. | Sullivan PF et al. | — | 2009 | → |
| Genomewide association studies: history, rationale, and prospects for psychiatric disorders. | Psychiatric GWAS Consortium Coordinating Committee et al. | — | 2009 | → |
| Migraine in recurrent depression: case-control study. | Samaan Z et al. | — | 2009 | → |
| Molecular epidemiology of major depressive disorder. | Kiyohara C et al. | — | 2009 | → |
| Population-specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women. | Lin YM et al. | — | 2009 | → |
| Prevalence and factors associated with depressive symptoms in Malay women. | Din MO et al. | — | 2009 | → |
| The role of genetic variation in the causation of mental illness: an evolution-informed framework. | Uher R | — | 2009 | → |
| Unipolar depressive disorders have a common genotype. | Edvardsen J et al. | — | 2009 | → |
| Age-specific familial risks of depression: a nation-wide epidemiological study from Sweden. | Li X et al. | — | 2008 | → |
| Colombo Twin and Singleton Study (CoTASS): a description of a population based twin study of mental disorders in Sri Lanka. | Siribaddana SH et al. | — | 2008 | → |
| Depression in an evolutionary context. | Wolpert L | — | 2008 | → |
| Familiality of major depressive disorder and gender differences in comorbidity. | Verhagen M et al. | — | 2008 | → |
| Familial risks for depression among siblings based on hospitalizations in Sweden. | Li X et al. | — | 2008 | → |
| Family history of depression is associated with younger age of onset in patients with recurrent depression. | Tozzi F et al. | — | 2008 | → |
| Heritability of bipolar spectrum disorders. Unity or heterogeneity? | Edvardsen J et al. | — | 2008 | → |
| Mitochondrial function is related to alterations at brain SPECT in depressed patients. | Gardner A et al. | — | 2008 | → |
| The implications of gene-environment interactions in depression: will cause inform cure? | Uher R | — | 2008 | → |
| Why do we need to understand the molecular basis of depression? | Rucker JJ et al. | — | 2008 | → |
| Clinical presentation of postnatal and non-postnatal depressive episodes. | Cooper C et al. | — | 2007 | → |
| Gene polymorphisms and behavior. | McGuffin P | — | 2007 | → |
| Genetic and environmental contributions to depressive personality disorder in a population-based sample of Norwegian twins. | Ørstavik RE et al. | — | 2007 | → |
| Genetic pathway of major depressive disorder in shortening telomeric length. | Lung FW et al. | — | 2007 | → |
| Genetics of recurrent early-onset major depression (GenRED): final genome scan report. | Holmans P et al. | — | 2007 | → |
| Genetic variation and shared biological susceptibility underlying comorbidity in neuropsychiatry. | Palomo T et al. | — | 2007 | → |
| Interrelationship of childhood trauma, neuroticism, and depressive phenotype. | Moskvina V et al. | — | 2007 | → |
| Religiousness, antisocial behavior, and altruism: genetic and environmental mediation. | Koenig LB et al. | — | 2007 | → |
| Twin pair resemblance for psychiatric hospitalization in the Swedish Twin Registry: a 32-year follow-up study of 29,602 twin pairs. | Prescott CA et al. | — | 2007 | → |
| Association of a D2S2944 allele with depression specifically among those with substance abuse or antisocial personality. | Langbehn DR et al. | — | 2006 | → |
| A Swedish national twin study of lifetime major depression. | Kendler KS et al. | — | 2006 | → |
| Depression in children and adolescents: linking risk research and prevention. | Garber J | — | 2006 | → |
| Effects of genes and stress on the neurobiology of depression. | Mann JJ et al. | — | 2006 | → |
| Gene-environment interplay and psychopathology: multiple varieties but real effects. | Rutter M et al. | — | 2006 | → |
| P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. | Lucae S et al. | — | 2006 | → |
| Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. | Wong ML et al. | — | 2006 | → |
| Protective effect of the apo epsilon2 allele in major depressive disorder in Taiwanese. | Fan PL et al. | — | 2006 | → |
| Sex differences in the familial transmission of mood disorders. | Currier D et al. | — | 2006 | → |
| The genetics of depression: a review. | Levinson DF | — | 2006 | → |
| Children of a cohort of depressed patients 25 years on: identifying those at risk. | Peisah C et al. | — | 2005 | → |
| Current strategies for investigating the genetic and environmental risk factors for affective disorders. | Farmer A et al. | — | 2005 | → |
| Dissecting the genetic etiology of major depressive disorder using linkage analysis. | Camp NJ et al. | — | 2005 | → |
| The genetics of depression and related traits. | Huezo-Diaz P et al. | — | 2005 | → |
| Whole genome linkage scan of recurrent depressive disorder from the depression network study. | McGuffin P et al. | — | 2005 | → |
| Anxious-retarded depression: relation to family history of depression. | de Winter RF et al. | — | 2004 | → |
| A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders. | Shih RA et al. | — | 2004 | → |
| Association of tryptophan hydroxylase gene polymorphism with depression, anxiety and comorbid depression and anxiety in a population-based sample of postpartum Taiwanese women. | Sun HS et al. | — | 2004 | → |
| Gene-environment interaction and the genetics of depression. | Lesch KP | — | 2004 | → |
| Genetics of major mood disorders. | Berrettini W | — | 2004 | → |
| Genomewide significant linkage to recurrent, early-onset major depressive disorder on chromosome 15q. | Holmans P et al. | — | 2004 | → |
| The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study. | Farmer A et al. | — | 2004 | → |
| Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression. | Tadic A et al. | — | 2003 | → |
| A twin study of depression symptoms, hypertension, and heart disease in middle-aged men. | Scherrer JF et al. | — | 2003 | → |
| Boundaries of schizophrenia. | Adler CM et al. | — | 2003 | → |
| Depressive-like behavior and stress reactivity are independent traits in a Wistar Kyoto x Fisher 344 cross. | Solberg LC et al. | — | 2003 | → |
| Fifty years of the double helix and its impact on psychiatry. | McGuffin P et al. | — | 2003 | → |
| Genetics of recurrent early-onset depression (GenRED): design and preliminary clinical characteristics of a repository sample for genetic linkage studies. | Levinson DF et al. | — | 2003 | → |
| N-ethyl-N-nitrosourea mouse mutants in the dissection of behavioural and psychiatric disorders. | Keays DA et al. | — | 2003 | → |
| The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. | Claes S et al. | — | 2003 | → |
| The heritability of depression symptoms in elderly Danish twins: occasion-specific versus general effects. | McGue M et al. | — | 2003 | → |
| Clinical features of major depressive disorder in adolescents and their relatives: impact on familial aggregation, implications for phenotype definition, and specificity of transmission. | Klein DN et al. | — | 2002 | → |
| Clinical profiles relating gender and depressive symptoms among adolescents ascertained by the Beck Depression Inventory II. | Coelho R et al. | — | 2002 | → |
| D2S2944 identifies a likely susceptibility locus for recurrent, early-onset, major depression in women. | Zubenko GS et al. | — | 2002 | → |
| Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depression. | Zubenko GS et al. | — | 2002 | → |
| Genetic segregation analysis of recurrent, early-onset major depression: evidence for single major locus transmission. | Maher BS et al. | — | 2002 | → |
| Genome survey for susceptibility loci for recurrent, early-onset major depression: results at 10cM resolution. | Zubenko GS et al. | — | 2002 | → |
| Life events, stress and depression: a review of recent findings. | Tennant C | — | 2002 | → |
| Parental depression and depression in offspring: evidence for familial characteristics and subtypes? | Lieb R et al. | — | 2002 | → |
| The genetic aetiology of childhood depression: a review. | Rice F et al. | — | 2002 | → |
| The genetic basis for psychiatric illness in man. | Tandon K et al. | — | 2002 | → |
| Toward a comprehensive developmental model for major depression in women. | Kendler KS et al. | — | 2002 | → |
| Malignancy of recurrent, early-onset major depression: a family study. | Zubenko GS et al. | — | 2001 | → |
| Psychiatric genetics: recent advances and clinical implications. | Corsico A et al. | — | 2001 | → |
| Sequential interactions in the parent-child communications of depressed fathers and depressed mothers. | Jacob T et al. | — | 2001 | → |
| Toward a new classification of risk factors for suicide behavior. | Marusic A et al. | — | 2001 | → |
| What can psychiatric genetics offer suicidology? | McGuffin P et al. | — | 2001 | → |
| Correlates of symptomatic, minor and major depression in the elderly. | Van den Berg MD et al. | — | 2000 | → |
| Gender differences in depression. Critical review. | Piccinelli M et al. | — | 2000 | → |
| Genetic epidemiology of major depression: review and meta-analysis. | Sullivan PF et al. | — | 2000 | → |
| Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the "kindling" hypothesis. | Kendler KS et al. | — | 2000 | → |
| Susceptibility loci for bipolar disorder: overlap with inherited vulnerability to schizophrenia. | Berrettini WH | — | 2000 | → |
| The genetics of major depressive disorder. | Malhi GS et al. | — | 2000 | → |
| A note on issues in meta-analysis for behavioral genetic studies using categorical phenotypes. | Ridenour TA et al. | — | 1999 | → |
| Molecular linkage studies of bipolar disorder. | Berrettini WH | — | 1999 | → |
| Science, medicine, and the future. Behaviour and genes. | McGuffin P et al. | — | 1999 | → |
| Genetic and non-genetic subtypes of major depressive disorder. | Andrew M et al. | — | 1998 | → |
| Recovery from major depression is not associated with normalization of serotonergic function. | Flory JD et al. | — | 1998 | → |
| Psychiatric genetics. | Craddock N | — | 1996 | → |