Integrative genomics identifies LMO1 as a neuroblastoma oncogene.
paper
Cited
Public
- Authors
- Wang, Kai; Diskin, Sharon J; Zhang, Haitao; Attiyeh, Edward F; Winter, Cynthia; Hou, Cuiping; Schnepp, Robert W; Diamond, Maura; Bosse, Kristopher; Mayes, Patrick A; Glessner, Joseph; Kim, Cecilia; Frackelton, Edward; Garris, Maria; Wang, Qun; Glaberson, Wendy; Chiavacci, Rosetta; Nguyen, Le; Jagannathan, Jayanti; Saeki, Norihisa; Sasaki, Hiroki; Grant, Struan F A; Iolascon, Achille; Mosse, Yael P; Cole, Kristina A; Li, Hongzhe; Devoto, Marcella; McGrady, Patrick W; London, Wendy B; Capasso, Mario; Rahman, Nazneen; Hakonarson, Hakon; Maris, John M
- Year
- 2011
- Journal
- Nature
- PMID
- 21124317
- DOI
- 10.1038/nature09609
- PMCID
- PMC3320515
Neuroblastoma is a childhood cancer of the sympathetic nervous system that accounts for approximately 10% of all paediatric oncology deaths. To identify genetic risk factors for neuroblastoma, we performed a genome-wide association study (GWAS) on 2,251 patients and 6,097 control subjects of European ancestry from four case series. Here we report a significant association within LIM domain only 1 (LMO1) at 11p15.4 (rs110419, combined P = 5.2βΓβ10(-16), odds ratio of risk allele = 1.34 (95% confidence interval 1.25-1.44)). The signal was enriched in the subset of patients with the most aggressive form of the disease. LMO1 encodes a cysteine-rich transcriptional regulator, and its paralogues (LMO2, LMO3 and LMO4) have each been previously implicated in cancer. In parallel, we analysed genome-wide DNA copy number alterations in 701 primary tumours. We found that the LMO1 locus was aberrant in 12.4% through a duplication event, and that this event was associated with more advanced disease (Pβ<β0.0001) and survival (P = 0.041). The germline single nucleotide polymorphism (SNP) risk alleles and somatic copy number gains were associated with increased LMO1 expression in neuroblastoma cell lines and primary tumours, consistent with a gain-of-function role in tumorigenesis. Short hairpin RNA (shRNA)-mediated depletion of LMO1 inhibited growth of neuroblastoma cells with high LMO1 expression, whereas forced expression of LMO1 in neuroblastoma cells with low LMO1 expression enhanced proliferation. These data show that common polymorphisms at the LMO1 locus are strongly associated with susceptibility to developing neuroblastoma, but also may influence the likelihood of further somatic alterations at this locus, leading to malignant progression.
Discovery of LMO1 at 11p15.4 as a neuroblastoma susceptibility locusa, Manhattan plot of GWAS results from the discovery cases series, with the red horizontal line representing genome-wide significance threshold (P < 5 Γ 10β8). b, Genomic position (National Center for Biotechnology Information build 36) of genotyped (triangles) and imputed (circles) SNPs. The P values are calculated by combining discovery and replication case series with whole-genome genotypes, and SNPs are coloured based on their correlations with rs110419 (purple diamond). Estimated recombination rates from the HapMap data are overlaid. c, Degree of linkage disequilibrium between SNPs (as r2 values) is represented by red colour intensity in the corresponding cells.
LMO1 germline genotypes and somatic copy number gains are associated with mRNA and protein expressiona, LMO1 mRNA and protein expression in nine human neuroblastoma-derived cell lines are highly correlated with rs110419 genotype. b, Microarray-based expression profiling on 61 primary tumours confirms that LMO1 gene expression is associated with both LMO1 gain (P = 0.02, t-test) and risk genotypes (P = 0.022, linear regression). c, Quantitative PCR-based expression profiling of an independent set of primary neuroblastomas without LMO1 gain confirms the same association. Error bars, s.e.m.
Genetic manipulation of LMO1 expression in neuroblastoma cell line models influences proliferative phenotype in an expression-specific manneraβd, In cells with neuroblastoma risk alleles and higher LMO1 expression levels, LMO1 knockdown leads to inhibition of cellular proliferation. e, LMO1 knockdown as measured by quantitative reverse-transcription PCR and western blot for experiments aβd. f, In SK-N-BE2C cells with non-risk alleles and low LMO1 expression levels, forced overexpression of LMO1 leads to enhanced cellular proliferation. Approximate fourfold overexpression of LMO1 RNA and protein are shown. Error bars, s.e.m.
| # | Section | Preview |
|---|---|---|
| 0 | METHODS SUMMARY | All genome-wide SNP genotyping for the discovery cohorts was performed using the Illumina⦠|
| 1 | METHODS SUMMARY | the expression measures for each probe set was extracted and normalized using robust multi-array⦠|
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| Association of MALAT1 gene polymorphisms with neuroblastoma susceptibility in children from Jiangsu Province. | Lian Y et al. | β | 2025 | β |
| Associations of <i>NEFL</i> gene polymorphisms with neuroblastoma risk in Chinese children from Jiangsu Province. | Chang X et al. | β | 2025 | β |
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| Genetic variants of m<sup>1</sup>A modification genes and the risk of neuroblastoma: novel insights from a Chinese case-control study. | Chang J et al. | β | 2025 | β |
| Improving neuroblastoma risk prediction through a polygenic risk score derived from genome-wide association study-identified loci. | Zhang W et al. | β | 2025 | β |
| Neuroblastoma susceptibility and association of N7-methylguanosine modification gene polymorphisms: multi-center case-control study. | Lin H et al. | β | 2025 | β |
| Overview of the etiology of childhood cancer and future directions. | Hoang TT et al. | β | 2025 | β |
| Prognostic Biomarkers in Breast Cancer via Multi-Omics Clustering Analysis. | Malighetti F et al. | β | 2025 | β |
| Re-envisioning genetic predisposition to childhood and adolescent cancers. | Kratz CP | β | 2025 | β |
| Skeletal dysplasia-causing mutations in TRPV4 alter the chondrocyte transcriptomic response to mechanical loading. | Harissa Z et al. | β | 2025 | β |
| The NSUN5 gene rs1880948 A>G polymorphism and neuroblastoma risk in Chinese children. | Ye Z et al. | β | 2025 | β |
| The relative contributions of genetic and non-genetic factors to the risk of neuroblastoma. | Jung EM et al. | β | 2025 | β |
| Effects of interleukin-15 on autophagy regulation in the skeletal muscle of mice. | Tanaka M et al. | β | 2024 | β |
| Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac development and early indicators of cardiac risk | Tan K et al. | β | 2024 | β |
| Ethyl Acetate Fraction from Hedyotis Diffusa Plus Scutellaria Barbata Inhibits the Progression of Breast Cancer <i>via</i> Targeting LMO1 and AKT/Mtor Signaling Pathway. | Li Z et al. | β | 2024 | β |
| Functional TET2 gene polymorphisms increase the risk of neuroblastoma in Chinese children. | Lin L et al. | β | 2024 | β |
| Genetic variants of m7G modification genes influence neuroblastoma susceptibility. | Liu J et al. | β | 2024 | β |
| Germline functional variants contribute to somatic mutation and outcomes in neuroblastoma. | Seo ES et al. | β | 2024 | β |
| Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival. | Kim J et al. | β | 2024 | β |
| Integrative genomic analyses identify neuroblastoma risk genes involved in neuronal differentiation. | Tirelli M et al. | β | 2024 | β |
| Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation. | Banerjee D et al. | β | 2024 | β |
| LMO family gene polymorphisms and Wilms tumor susceptibility in Chinese children: a five-center case-control study. | Fu W et al. | β | 2024 | β |
| Super-enhancers: drivers of cells' identities and cells' debacles. | Lavaud M et al. | β | 2024 | β |
| ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors. | Wang L et al. | β | 2023 | β |
| Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state. | Weichert-Leahey N et al. | β | 2023 | β |
| Metastasis in neuroblastoma: the <i>MYCN</i> question. | Bhavsar SP | β | 2023 | β |
| RTEL1 gene polymorphisms and neuroblastoma risk in Chinese children. | Zhang T et al. | β | 2023 | β |
| Targeted parallel DNA sequencing detects circulating tumor-associated variants of the mitochondrial and nuclear genomes in patients with neuroblastoma. | Riehl L et al. | β | 2023 | β |
| Exploration of genetic ancestry and socioeconomic status in the incidence of neuroblastoma: An ecological study. | Jung EM et al. | β | 2022 | β |
| Genetic Analysis in African American Children Supports Ancestry-Specific Neuroblastoma Susceptibility. | Testori A et al. | β | 2022 | β |
| Gene utility recapitulates chromosomal aberrancies in advanced stage neuroblastoma. | Ung CY et al. | β | 2022 | β |
| Identification of Mitochondrial DNA Variants Associated With Risk of Neuroblastoma. | Chang X et al. | β | 2022 | β |
| Identification of the Transcription Co-Factor-Related Gene Signature and Risk Score Model for Osteosarcoma. | Jin Z et al. | β | 2022 | β |
| LMO1 Plays an Oncogenic Role in Human Glioma Associated With NF-kB Pathway. | Gao L et al. | β | 2022 | β |
| Lung- and liver-dominant phenotypes of Korean eight constitution medicine have different profiles of genotype associated with each organ function. | Kim C et al. | β | 2022 | β |
| Recent advances in the developmental origin of neuroblastoma: an overview. | Ponzoni M et al. | β | 2022 | β |
| Somatic Mutations Enriched in Cis-Regulatory Elements Affect Genes Involved in Embryonic Development and Immune System Response in Neuroblastoma. | Lasorsa VA et al. | β | 2022 | β |
| Association between NER pathway gene polymorphisms and neuroblastoma risk in an eastern Chinese population. | Zhou C et al. | β | 2021 | β |
| Associations between <i>LMO1</i> gene polymorphisms and central nervous system tumor susceptibility. | Lin H et al. | β | 2021 | β |
| Associations between <i>WTAP</i> gene polymorphisms and neuroblastoma susceptibility in Chinese children. | Tang J et al. | β | 2021 | β |
| GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma. | Dong Z et al. | β | 2021 | β |
| Growth factor signaling predicts therapy resistance mechanisms and defines neuroblastoma subtypes. | Lebedev T et al. | β | 2021 | β |
| <i>YTHDC1</i> gene polymorphisms and neuroblastoma susceptibility in Chinese children. | Li Y et al. | β | 2021 | β |
| <i>YTHDF1</i> gene polymorphisms and neuroblastoma susceptibility in Chinese children: an eight-center case-control study. | Liu J et al. | β | 2021 | β |
| LIM domain only 1: an oncogenic transcription cofactor contributing to the tumorigenesis of multiple cancer types. | Zhao GF et al. | β | 2021 | β |
| Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma. | Anderson NM et al. | β | 2021 | β |
| Molecular Genetics in Neuroblastoma Prognosis. | Lerone M et al. | β | 2021 | β |
| Prognostic Signature of Immune Genes and Immune-Related LncRNAs in Neuroblastoma: A Study Based on GEO and TARGET Datasets. | Zhong X et al. | β | 2021 | β |
| Therapeutically targeting oncogenic CRCs facilitates induced differentiation of NB by RA and the BET bromodomain inhibitor. | Alleboina S et al. | β | 2021 | β |
| Unraveling Gene Fusions for Drug Repositioning in High-Risk Neuroblastoma. | Liu Z et al. | β | 2021 | β |
| A Comprehensive Genome-Wide and Phenome-Wide Examination of BMI and Obesity in a Northern Nevadan Cohort. | Schlauch KA et al. | β | 2020 | β |
| Association of MYC gene polymorphisms with neuroblastoma risk in Chinese children: A four-center case-control study. | Pan J et al. | β | 2020 | β |
| Cancer Progress and Priorities: Childhood Cancer. | Lupo PJ et al. | β | 2020 | β |
| Genetic predisposition and chromosome instability in neuroblastoma. | Tonini GP et al. | β | 2020 | β |
| Genetic Predisposition to Solid Pediatric Cancers. | Capasso M et al. | β | 2020 | β |
| Genetic variation associated with childhood and adult stature and risk of MYCN-amplified neuroblastoma. | Semmes EC et al. | β | 2020 | β |
| Genome-Wide Association Study for the Identification of Novel Genetic Variants Associated with the Risk of Neuroblastoma in Korean Children. | Bae JS et al. | β | 2020 | β |
| Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles. | Giwa A et al. | β | 2020 | β |
| <i>HMGA2</i> Gene rs8756 A>C Polymorphism Reduces Neuroblastoma Risk in Chinese Children: A Four-Center Case-Control Study. | Liu J et al. | β | 2020 | β |
| Large genome-wide association study identifies three novel risk variants for restless legs syndrome. | Didriksen M et al. | β | 2020 | β |
| LMO1 polymorphisms and the risk of neuroblastoma: Assessment of meta-analysis of case-control studies. | Hashemi M et al. | β | 2020 | β |
| Microsphere-assisted interferometry with high numerical apertures for 3D topography measurements. | HΓΌser L et al. | β | 2020 | β |
| Mitochondrial DNA Haplogroups and Susceptibility to Neuroblastoma. | Chang X et al. | β | 2020 | β |
| Nervous system: Embryonal tumors: Neuroblastoma. | Pudela C et al. | β | 2020 | β |
| Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibility locus that shows a long-range interaction with the SLC16A1 gene. | Avitabile M et al. | β | 2020 | β |
| Pediatric Cancer Models in Zebrafish. | Casey MJ et al. | β | 2020 | β |
| TP53 Arg72Pro polymorphism and neuroblastoma susceptibility in eastern Chinese children: a three-center case-control study. | Fang Y et al. | β | 2020 | β |
| ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry. | Wang L et al. | β | 2019 | β |
| Association of <i>miR-146a, miR-149</i> and <i>miR-196a2</i> polymorphisms with neuroblastoma risk in Eastern Chinese population: a three-center case-control study. | Zhou C et al. | β | 2019 | β |
| Association of <i>NEFL</i> Gene Polymorphisms with Wilms' Tumor Susceptibility in Chinese Children. | Jia W et al. | β | 2019 | β |
| Association of miR-34b/c rs4938723 and TP53 Arg72Pro Polymorphisms with Neuroblastoma Susceptibility: Evidence from Seven Centers. | Li L et al. | β | 2019 | β |
| Collaborative ISL1/GATA3 interaction in controlling neuroblastoma oncogenic pathways overlapping with but distinct from MYCN. | Zhang Q et al. | β | 2019 | β |
| Congenital malformation syndromes associated with peripheral neuroblastic tumors: A systematic review. | Sznewajs A et al. | β | 2019 | β |
| Development and Validation of an RNA-Seq-Based Prognostic Signature in Neuroblastoma. | Zhou JG et al. | β | 2019 | β |
| Functional Polymorphisms in <i>BARD1</i> Association with Neuroblastoma in a regional Han Chinese Population. | Shi J et al. | β | 2019 | β |
| Germline 16p11.2 Microdeletion Predisposes to Neuroblastoma. | Egolf LE et al. | β | 2019 | β |
| <i>APEX1</i> Polymorphisms and Neuroblastoma Risk in Chinese Children: A Three-Center Case-Control Study. | Liu J et al. | β | 2019 | β |
| <i>KRAS</i> rs7973450 A>G increases neuroblastoma risk in Chinese children: a four-center case-control study. | Lin A et al. | β | 2019 | β |
| <i>LMO1</i> Super-Enhancer rs2168101 G>T Polymorphism Reduces Wilms Tumor Risk. | Li G et al. | β | 2019 | β |
| <i>TP53</i> gene rs1042522 allele G decreases neuroblastoma risk: a two-centre case-control study. | Zhang J et al. | β | 2019 | β |
| MicroRNAs in neuroblastoma tumorigenesis, therapy resistance, and disease evolution. | Aravindan N et al. | β | 2019 | β |
| Neuroblastoma-A Neural Crest Derived Embryonal Malignancy. | Johnsen JI et al. | β | 2019 | β |
| Association between <i>NEFL</i> Gene Polymorphisms and Neuroblastoma Risk in Chinese Children: A Two-Center Case-Control Study. | Wu Q et al. | β | 2018 | β |
| Association of Common Genetic Variants in Pre-microRNAs and Neuroblastoma Susceptibility: A Two-Center Study in Chinese Children. | He J et al. | β | 2018 | β |
| Chromatin Immunoprecipitation and DNA Sequencing Identified a LIMS1/ILK Pathway Regulated by LMO1 in Neuroblastoma. | Saeki N et al. | β | 2018 | β |
| Coexpression network analysis identifies transcriptional modules associated with genomic alterations in neuroblastoma. | Yang L et al. | β | 2018 | β |
| Fine mapping of 2q35 high-risk neuroblastoma locus reveals independent functional risk variants and suggests full-length BARD1 as tumor-suppressor. | Cimmino F et al. | β | 2018 | β |
| Functional Polymorphisms at ERCC1/XPF Genes Confer Neuroblastoma Risk in Chinese Children. | Zhuo ZJ et al. | β | 2018 | β |
| Genetic Predisposition to Neuroblastoma. | Barr EK et al. | β | 2018 | β |
| Genetic susceptibility to neuroblastoma: current knowledge and future directions. | Ritenour LE et al. | β | 2018 | β |
| Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients. | Koster R et al. | β | 2018 | β |
| Genome-wide association study of offspring birth weight in 86β577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. | Beaumont RN et al. | β | 2018 | β |
| HOTAIR gene polymorphisms contribute to increased neuroblastoma susceptibility in Chinese children. | Yang X et al. | β | 2018 | β |
| <i>LMO1</i> Gene Polymorphisms Reduce Neuroblastoma Risk in Eastern Chinese Children: A Three-Center Case-Control Study. | He L et al. | β | 2018 | β |
| <i>LMO1</i> super-enhancer polymorphism rs2168101 G>T correlates with decreased neuroblastoma risk in Chinese children. | He J et al. | β | 2018 | β |
| Indirect Down-regulation of Tumor-suppressive <i>let-7</i> Family MicroRNAs by <i>LMO1</i> in Neuroblastoma. | Saeki N et al. | β | 2018 | β |
| <i>XPA</i> gene polymorphisms and risk of neuroblastoma in Chinese children: a two-center case-control study. | Tao J et al. | β | 2018 | β |
| <i>XRCC1</i> gene polymorphisms and risk of neuroblastoma in Chinese children. | Zhang J et al. | β | 2018 | β |
| Lack of associations between <i>AURKA</i> gene polymorphisms and neuroblastoma susceptibility in Chinese children. | Tang J et al. | β | 2018 | β |
| LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer. | Du L et al. | β | 2018 | β |
| Neuroblastoma. | Nakagawara A et al. | β | 2018 | β |
| Rs3212986 polymorphism, a possible biomarker to predict smoking-related lung cancer, alters DNA repair capacity via regulating ERCC1 expression. | Yu T et al. | β | 2018 | β |
| Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis. | Mondal T et al. | β | 2018 | β |
| Serum Interleukin-6 Level and the rs1800795 Polymorphism in its Gene Associated with Neuroblastoma Risk in Chinese Children. | Zhao Q et al. | β | 2018 | β |
| SP8 Transcriptional Regulation of <i>Cyclin D1</i> During Mouse Early Corticogenesis. | Borello U et al. | β | 2018 | β |
| Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. | Zhang Q et al. | β | 2018 | β |
| Tumor-suppressive function of SIRT4 in neuroblastoma through mitochondrial damage. | Wang Y et al. | β | 2018 | β |
| Unraveling Neuroblastoma Pathogenesis with the Zebrafish. | Dankert EN et al. | β | 2018 | β |
| A c-Myc-regulated stem cell-like signature in high-risk neuroblastoma: A systematic discovery (Target neuroblastoma ESC-like signature). | Yang XH et al. | β | 2017 | β |
| Altered TERT promoter and other genomic regulatory elements: occurrence and impact. | Heidenreich B et al. | β | 2017 | β |
| Associations between <i>LMO1</i> gene polymorphisms and Wilms' tumor susceptibility. | Liu GC et al. | β | 2017 | β |
| CDC20siRNA and paclitaxel co-loaded nanometric liposomes of a nipecotic acid-derived cationic amphiphile inhibit xenografted neuroblastoma. | Bhunia S et al. | β | 2017 | β |
| Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk. | Chang X et al. | β | 2017 | β |
| Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma. | McDaniel LD et al. | β | 2017 | β |
| Downregulation of bone morphogenetic protein receptor 2 promotes the development of neuroblastoma. | Cui X et al. | β | 2017 | β |
| Dualistic Role of BARD1 in Cancer. | Cimmino F et al. | β | 2017 | β |
| Emerging Opportunities for Target Discovery in Rare Cancers. | Sharifnia T et al. | β | 2017 | β |
| Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma. | Veschi V et al. | β | 2017 | β |
| Evaluation of Genetic Predisposition for MYCN-Amplified Neuroblastoma. | Hungate EA et al. | β | 2017 | β |
| Genetic susceptibility to neuroblastoma. | Tolbert VP et al. | β | 2017 | β |
| Genetic Variations of GWAS-Identified Genes and Neuroblastoma Susceptibility: a Replication Study in Southern Chinese Children. | He J et al. | β | 2017 | β |
| <i>CASC15</i> gene polymorphisms reduce neuroblastoma risk in Chinese children. | Zhang J et al. | β | 2017 | β |
| <i>HSD17B12</i> gene rs11037575 C>T polymorphism confers neuroblastoma susceptibility in a Southern Chinese population. | Zhang Z et al. | β | 2017 | β |
| <i>LMO1</i> polymorphisms reduce neuroblastoma risk in Chinese children: a two-center case-control study. | Zhang J et al. | β | 2017 | β |
| Incorporating genomic, transcriptomic and clinical data: a prognostic and stem cell-like MYC and PRC imbalance in high-risk neuroblastoma. | Yang XH et al. | β | 2017 | β |
| Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors. | Ohshima K et al. | β | 2017 | β |
| LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. | Zhu S et al. | β | 2017 | β |
| Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor. | Takagi M et al. | β | 2017 | β |
| Maternal diabetes and incidence of childhood cancer - a nationwide cohort study and exploratory genetic analysis. | Deleskog A et al. | β | 2017 | β |
| Neuroblastoma in children: Update on clinicopathologic and genetic prognostic factors. | Ahmed AA et al. | β | 2017 | β |
| Overview and recent advances in the treatment of neuroblastoma. | Whittle SB et al. | β | 2017 | β |
| Racial and Ethnic Disparities in the Incidence of Pediatric Extracranial Embryonal Tumors. | Friedrich P et al. | β | 2017 | β |
| Rapid identification of a new gene influencing low amylose content in rice landraces (Oryza sativa L.) using genome-wide association study with specific-locus amplified fragment sequencing. | Yang X et al. | β | 2017 | β |
| Research progress of neuroblastoma related gene variations. | Cao Y et al. | β | 2017 | β |
| Retinoic acid and TGF-Ξ² signalling cooperate to overcome MYCN-induced retinoid resistance. | Duffy DJ et al. | β | 2017 | β |
| Socioeconomic status and global variations in the incidence of neuroblastoma: call for support of population-based cancer registries in low-middle-income countries. | Kamihara J et al. | β | 2017 | β |
| Sub-micromolar concentrations of retinoic acid induce morphological and functional neuronal phenotypes in SK-N-SH neuroblastoma cells. | Harasym E et al. | β | 2017 | β |
| The functional variant rs34330 of CDKN1B is associated with risk of neuroblastoma. | Capasso M et al. | β | 2017 | β |
| Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines. | Harenza JL et al. | β | 2017 | β |
| When LMO1 Meets MYCN, Neuroblastoma Is Metastatic. | Liu Z et al. | β | 2017 | β |
| A comprehensive characterization of rare mitochondrial DNA variants in neuroblastoma. | Calabrese FM et al. | β | 2016 | β |
| Advances in the translational genomics of neuroblastoma: From improving risk stratification and revealing novel biology to identifying actionable genomic alterations. | Bosse KR et al. | β | 2016 | β |
| A family-based study of gene variants and maternal folate and choline in neuroblastoma: a report from the Children's Oncology Group. | Mazul AL et al. | β | 2016 | β |
| Association of potentially functional variants in the XPG gene with neuroblastoma risk in a Chinese population. | He J et al. | β | 2016 | β |
| Cooperation between somatic mutations and germline susceptibility variants in tumorigenesis - a dangerous liaison. | GrΓΌnewald TG et al. | β | 2016 | β |
| Emergence of the Noncoding Cancer Genome: A Target of Genetic and Epigenetic Alterations. | Zhou S et al. | β | 2016 | β |
| Evaluation of GWAS-identified SNPs at 6p22 with neuroblastoma susceptibility in a Chinese population. | He J et al. | β | 2016 | β |
| Genetic discoveries and treatment advances in neuroblastoma. | Bagatell R et al. | β | 2016 | β |
| Lack of Associations between <i>XPC</i> Gene Polymorphisms and Neuroblastoma Susceptibility in a Chinese Population. | Zheng J et al. | β | 2016 | β |
| LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population. | He J et al. | β | 2016 | β |
| Neuroblastoma and Its Zebrafish Model. | Zhu S et al. | β | 2016 | β |
| Neuroblastoma, a Paradigm for Big Data Science in Pediatric Oncology. | Salazar BM et al. | β | 2016 | β |
| Neuroblastoma: A Tough Nut to Crack. | Speleman F et al. | β | 2016 | β |
| Neuroblastoma in early childhood: A rare case report and review of literature. | Kalaskar RR et al. | β | 2016 | β |
| Oncologic Phenotype of Peripheral Neuroblastic Tumors Associated With PHOX2B Non-Polyalanine Repeat Expansion Mutations. | Heide S et al. | β | 2016 | β |
| Potentially functional polymorphisms in the LIN28B gene contribute to neuroblastoma susceptibility in Chinese children. | He J et al. | β | 2016 | β |
| Recent biologic and genetic advances in neuroblastoma: Implications for diagnostic, risk stratification, and treatment strategies. | Newman EA et al. | β | 2016 | β |
| Single nucleotide polymorphism rs11669203 in TGFBR3L is associated with the risk of neuroblastoma in a Chinese population. | Jin Y et al. | β | 2016 | β |
| The Association between GWAS-identified BARD1 Gene SNPs and Neuroblastoma Susceptibility in a Southern Chinese Population. | Zhang R et al. | β | 2016 | β |
| The LMO2 oncogene regulates DNA replication in hematopoietic cells. | Sincennes MC et al. | β | 2016 | β |
| The zebrafish as a model for studying neuroblastoma. | Corallo D et al. | β | 2016 | β |
| A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis. | Schnepp RW et al. | β | 2015 | β |
| Alternative splicing in cancer: implications for biology and therapy. | Chen J et al. | β | 2015 | β |
| Association between the TERT Genetic Polymorphism rs2853676 and Cancer Risk: Meta-Analysis of 76,108 Cases and 134,215 Controls. | Cao JL et al. | β | 2015 | β |
| Candidate Gene Association Analysis of Neuroblastoma in Chinese Children Strengthens the Role of LMO1. | Lu J et al. | β | 2015 | β |
| CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus. | Russell MR et al. | β | 2015 | β |
| Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite. | GrΓΌnewald TG et al. | β | 2015 | β |
| Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma. | Nie Z et al. | β | 2015 | β |
| Genetic and nongenetic risk factors for childhood cancer. | Spector LG et al. | β | 2015 | β |
| Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism. | Oldridge DA et al. | β | 2015 | β |
| Identification of GALNT14 as a novel neuroblastoma predisposition gene. | De Mariano M et al. | β | 2015 | β |
| Microarray data analysis of neuroblastoma: Expression of SOX2 downregulates the expression of MYCN. | Bao J et al. | β | 2015 | β |
| Neuroblastoma: paradigm for precision medicine. | Irwin MS et al. | β | 2015 | β |
| Retroperitoneal catecholamine-producing ganglioneuroma with a birth history of monozygotic twins who both suffered from neuroblastoma during their childhoods: a case report with genome analysis. | Ishihara H et al. | β | 2015 | β |
| The role of intracellular calcium for the development and treatment of neuroblastoma. | Satheesh NJ et al. | β | 2015 | β |
| Upregulated LMO1 in prostate cancer acts as a novel coactivator of the androgen receptor. | Gu H et al. | β | 2015 | β |
| CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients. | Rihani A et al. | β | 2014 | β |
| Common genetic variants in NEFL influence gene expression and neuroblastoma risk. | Capasso M et al. | β | 2014 | β |
| Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex. | Sewell H et al. | β | 2014 | β |
| Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. | Hackett CS et al. | β | 2014 | β |
| Genome-wide association study of blast resistance in indica rice. | Wang C et al. | β | 2014 | β |
| Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. | Murakami-Tonami Y et al. | β | 2014 | β |
| Integrated transcriptome analysis reveals miRNA-mRNA crosstalk in laryngeal squamous cell carcinoma. | Zhang Y et al. | β | 2014 | β |
| Integrating cell-based and clinical genome-wide studies to identify genetic variants contributing to treatment failure in neuroblastoma patients. | Pinto N et al. | β | 2014 | β |
| Lack of association between MDM2 promoter SNP309 and clinical outcome in patients with neuroblastoma. | Rihani A et al. | β | 2014 | β |
| LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins. | Sang M et al. | β | 2014 | β |
| Mechanisms of neuroblastoma regression. | Brodeur GM et al. | β | 2014 | β |
| Rare variants in TP53 and susceptibility to neuroblastoma. | Diskin SJ et al. | β | 2014 | β |
| Recent insights into the biology of neuroblastoma. | Schleiermacher G et al. | β | 2014 | β |
| The promises and pitfalls of genetic epidemiologic approaches to pediatric cancers: lessons from MDM2. | McDaniel LD et al. | β | 2014 | β |
| A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. | Kapoor M et al. | β | 2013 | β |
| Apoptotic cell death in neuroblastoma. | Li Y et al. | β | 2013 | β |
| Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia. | Oram SH et al. | β | 2013 | β |
| Children's Oncology Group's 2013 blueprint for research: neuroblastoma. | Park JR et al. | β | 2013 | β |
| Comparative drug pair screening across multiple glioblastoma cell lines reveals novel drug-drug interactions. | Schmidt L et al. | β | 2013 | β |
| Gene expression profiles of metabolic aggressiveness and tumor recurrence in benign meningioma. | Serna E et al. | β | 2013 | β |
| Impact of interleukin-6 -174 G>C gene promoter polymorphism on neuroblastoma. | Totaro F et al. | β | 2013 | β |
| Inherited susceptibility to chronic lymphocytic leukemia: evidence and prospects for the future. | Brown JR | β | 2013 | β |
| Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. | Sausen M et al. | β | 2013 | β |
| LIM-domain-only proteins in cancer. | Matthews JM et al. | β | 2013 | β |
| LMO4 is an essential cofactor in the Snail2-mediated epithelial-to-mesenchymal transition of neuroblastoma and neural crest cells. | Ferronha T et al. | β | 2013 | β |
| Neuroblastoma and MYCN. | Huang M et al. | β | 2013 | β |
| Neuroblastoma: developmental biology, cancer genomics and immunotherapy. | Cheung NK et al. | β | 2013 | β |
| Next-generation sequencing in understanding complex neurological disease. | Handel AE et al. | β | 2013 | β |
| Polymorphisms in the calcium-sensing receptor gene are associated with clinical outcome of neuroblastoma. | Masvidal L et al. | β | 2013 | β |
| Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma. | DeNardo BD et al. | β | 2013 | β |
| Replication of GWAS-identified neuroblastoma risk loci strengthens the role of BARD1 and affirms the cumulative effect of genetic variations on disease susceptibility. | Capasso M et al. | β | 2013 | β |
| The genetic landscape of high-risk neuroblastoma. | Pugh TJ et al. | β | 2013 | β |
| The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis. | Domingo-Fernandez R et al. | β | 2013 | β |
| Trans-population analysis of genetic mechanisms of ethnic disparities in neuroblastoma survival. | Gamazon ER et al. | β | 2013 | β |
| ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. | Qing G et al. | β | 2012 | β |
| Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. | Diskin SJ et al. | β | 2012 | β |
| Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. | Bosse KR et al. | β | 2012 | β |
| Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group. | Dubois SG et al. | β | 2012 | β |
| Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers. | Decock A et al. | β | 2012 | β |
| Integrative genomic analysis implicates gain of PIK3CA at 3q26 and MYC at 8q24 in chronic lymphocytic leukemia. | Brown JR et al. | β | 2012 | β |
| Neuroblastoma. | Davidoff AM | β | 2012 | β |
| Neuroblastoma: the impact of biology and cooperation leading to personalized treatments. | Owens C et al. | β | 2012 | β |
| New prognostic markers in neuroblastoma. | Navarro S et al. | β | 2012 | β |
| Replication of neuroblastoma SNP association at the BARD1 locus in African-Americans. | Latorre V et al. | β | 2012 | β |
| Reverse engineering biomolecular systems using -omic data: challenges, progress and opportunities. | Quo CF et al. | β | 2012 | β |
| Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis. | Mocellin S et al. | β | 2012 | β |
| The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform. | Cattelani S et al. | β | 2012 | β |
| Transcriptional enhancers in protein-coding exons of vertebrate developmental genes. | Ritter DI et al. | β | 2012 | β |
| Advances in the understanding of constitutional and somatic genomic alterations in neuroblastoma. | Deyell RJ et al. | β | 2011 | β |
| Candidate gene association analysis of acute lymphoblastic leukemia identifies new susceptibility locus at 11p15 (LMO1). | Beuten J et al. | β | 2011 | β |
| Challenges and opportunities for genomic developmental neuropsychology: examples from the Penn-Drexel collaborative battery. | Gur RC et al. | β | 2011 | β |
| Genetically engineered murine models--contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma. | Chesler L et al. | β | 2011 | β |
| Genome-wide association studies and systems biology: together at last. | Ala-Korpela M et al. | β | 2011 | β |
| Neuroblastoma genetics and phenotype: a tale of heterogeneity. | Speleman F et al. | β | 2011 | β |
| Phenotype restricted genome-wide association study using a gene-centric approach identifies three low-risk neuroblastoma susceptibility Loci. | Nguyen le B et al. | β | 2011 | β |
| Proceedings of the Tenth Annual UT-ORNL-KBRIN Bioinformatics Summit 2011. | Rouchka EC et al. | β | 2011 | β |
| Progress towards personalized therapeutics: biologic- and risk-directed therapy for neuroblastoma. | Gustafson WC et al. | β | 2011 | β |
| Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study). | Schleiermacher G et al. | β | 2011 | β |