The Creb1 coactivator Crtc1 is required for energy balance and fertility.
paper
Cited
Public
- Authors
- Altarejos, Judith Y; Goebel, Naomi; Conkright, Michael D; Inoue, Hiroshi; Xie, Jianxin; Arias, Carlos M; Sawchenko, Paul E; Montminy, Marc
- Year
- 2008
- Journal
- Nature medicine
- PMID
- 18758446
- DOI
- 10.1038/nm.1866
- PMCID
- PMC2667698
The adipocyte-derived hormone leptin maintains energy balance by acting on hypothalamic leptin receptors (Leprs) that act on the signal transducer and activator of transcription 3 (Stat3). Although disruption of Lepr-Stat3 signaling promotes obesity in mice, other features of Lepr function, such as fertility, seem normal, pointing to the involvement of additional regulators. Here we show that the cyclic AMP responsive element-binding protein-1 (Creb1)-regulated transcription coactivator-1 (Crtc1) is required for energy balance and reproduction-Crtc1(-/-) mice are hyperphagic, obese and infertile. Hypothalamic Crtc1 was phosphorylated and inactive in leptin-deficient ob/ob mice, while leptin administration increased amounts of dephosphorylated nuclear Crtc1. Dephosphorylated Crtc1 stimulated expression of the Cartpt and Kiss1 genes, which encode hypothalamic neuropeptides that mediate leptin's effects on satiety and fertility. Crtc1 overexpression in hypothalamic cells increased Cartpt and Kiss1 gene expression, whereas Crtc1 depletion decreased it. Indeed, leptin enhanced Crtc1 activity over the Cartpt and Kiss1 promoters in cells overexpressing Lepr, and these effects were disrupted by expression of a dominant-negative Creb1 polypeptide. As leptin administration increased recruitment of hypothalamic Crtc1 to Cartpt and Kiss1 promoters, our results indicate that the Creb1-Crtc1 pathway mediates the central effects of hormones and nutrients on energy balance and fertility.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Central and Peripheral Roles of Salt-inducible Kinases in Metabolic Regulation. | Onda DA et al. | β | 2025 | β |
| Regulation of Sleep Amount by CRTC1 via Transcription of <i>Crh</i> in Mice. | Liu Z et al. | β | 2025 | β |
| Circadian Rhythm Mechanisms Underlying Convergent Adaptation of Unihemispheric Slow-Wave Sleep in Marine Mammals. | Yin D et al. | β | 2024 | β |
| CREB coactivator CRTC1 in melanocortin-4 receptor-expressing cells regulate dietary fat intake. | Matsumura S et al. | β | 2024 | β |
| Crtc1 deficiency protects against sepsis-associated acute lung injury through activating akt signaling pathway. | Chen M et al. | β | 2024 | β |
| CRTC1 in Mc4r-Expressing Cells Is Required for Peripheral Metabolism and Systemic Energy Homeostasis. | Miyamori H et al. | β | 2024 | β |
| The nutrient sensor CRTC and Sarcalumenin/thinman represent an alternate pathway in cardiac hypertrophy. | Dondi C et al. | β | 2024 | β |
| A kidney-brain neural circuit drives progressive kidney damage and heart failure. | Cao W et al. | β | 2023 | β |
| Amphiregulin normalizes altered circuit connectivity for social dominance of the CRTC3 knockout mouse. | Park JS et al. | β | 2023 | β |
| CREB-Regulated Transcriptional Coactivator 2 Proteome Landscape is Modulated by SREBF1. | Lim JM et al. | β | 2023 | β |
| LncRNA TDRKH-AS1 promotes breast cancer progression via the miR-134-5p/CREB1 axis. | Ding Y et al. | β | 2023 | β |
| Regulation of insulin secretion by the post-translational modifications. | Yang C et al. | β | 2023 | β |
| The Pleiotropic Face of CREB Family Transcription Factors. | Chowdhury MAR et al. | β | 2023 | β |
| Transcriptional Dysregulations of Seven Non-Differentially Expressed Genes as Biomarkers of Metastatic Colon Cancer. | Lv X et al. | β | 2023 | β |
| Capsaicin and Zinc Promote Glucose Uptake in C2C12 Skeletal Muscle Cells through a Common Calcium Signalling Pathway. | Ferdowsi PV et al. | β | 2022 | β |
| CRTC1 deficiency, specifically in melanocortin-4 receptor-expressing cells, induces hyperphagia, obesity, and insulin resistance. | Matsumura S et al. | β | 2022 | β |
| Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior. | Cherix A et al. | β | 2022 | β |
| Hypothalamic CREB Regulates the Expression of Pomc-Processing Enzyme Pcsk2. | Zanesco AM et al. | β | 2022 | β |
| New Insights Into the Pivotal Role of CREB-Regulated Transcription Coactivator 1 in Depression and Comorbid Obesity. | Rossetti C et al. | β | 2022 | β |
| Prioritization and functional analysis of GWAS risk loci for Barrett's esophagus and esophageal adenocarcinoma. | Chen J et al. | β | 2022 | β |
| Crtc1 Deficiency Causes Obesity Potentially via Regulating PPARΞ³ Pathway in White Adipose. | Hu Y et al. | β | 2021 | β |
| CRTC3, a sensor and key regulator for melanogenesis, as a tunable therapeutic target for pigmentary disorders. | Yoo H et al. | β | 2021 | β |
| Crtc modulates fasting programs associated with 1-C metabolism and inhibition of insulin signaling. | Wang T et al. | β | 2021 | β |
| Eosinophil extracellular traps drive asthma progression through neuro-immune signals. | Lu Y et al. | β | 2021 | β |
| Loss of CREB Coactivator CRTC1 in SF1 Cells Leads to Hyperphagia and Obesity by High-fat Diet But Not Normal Chow Diet. | Matsumura S et al. | β | 2021 | β |
| Multiple Leptin Signalling Pathways in the Control of Metabolism and Fertility: A Means to Different Ends? | Evans MC et al. | β | 2021 | β |
| Palmitate-mediated induction of neuropeptide Y expression occurs through intracellular metabolites and not direct exposure to proinflammatory cytokines. | Tran A et al. | β | 2021 | β |
| Sex-specific pubertal and metabolic regulation of Kiss1 neurons via Nhlh2. | Leon S et al. | β | 2021 | β |
| Structural Insights into the Interaction Between CRTCs and 14-3-3. | Chen H et al. | β | 2021 | β |
| Tissue-specific activation of gene expression by the Synergistic Activation Mediator (SAM) CRISPRa system in mice. | Hunt C et al. | β | 2021 | β |
| Transcriptional co-activator regulates melanocyte differentiation and oncogenesis by integrating cAMP and MAPK/ERK pathways. | OstojiΔ J et al. | β | 2021 | β |
| Farnesoid X Receptor-Mediated Cytoplasmic Translocation of CRTC2 Disrupts CREB-BDNF Signaling in Hippocampal CA1 and Leads to the Development of Depression-Like Behaviors in Mice. | Hu W et al. | β | 2020 | β |
| KISS1R signaling modulates gonadotropin sensitivity in mouse Leydig cell. | Hsu MC et al. | β | 2020 | β |
| Physiological and genomic insight into neuroendocrine regulation of puberty in gilts. | Lents CA et al. | β | 2020 | β |
| Role of CRTC2 in Metabolic Homeostasis: Key Regulator of Whole-Body Energy Metabolism? | Han HS et al. | β | 2020 | β |
| Unravelling the role of epigenetics in reproductive adaptations to early-life environment. | Bar-Sadeh B et al. | β | 2020 | β |
| Anabolic and Pro-metabolic Functions of CREB-CRTC in Skeletal Muscle: Advantages and Obstacles for Type 2 Diabetes and Cancer Cachexia. | Berdeaux R et al. | β | 2019 | β |
| Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence. | Aylwin CF et al. | β | 2019 | β |
| (Epi)genetic regulation of CRTC1 in human eating behaviour and fat distribution. | Rohde K et al. | β | 2019 | β |
| Genetic and epigenetic regulation of CRTC1 in human eating behaviour and fat distribution: Methodological and clinical insights and considerations. | Booij L | β | 2019 | β |
| Genome Diversity and Signatures of Selection for Production and Performance Traits in Dromedary Camels. | Bahbahani H et al. | β | 2019 | β |
| Genome-Wide Association Analysis Reveals Key Genes Responsible for Egg Production of Lion Head Goose. | Zhao Q et al. | β | 2019 | β |
| Inhibition of Reactive Astrocytes with Fluorocitrate Ameliorates Learning and Memory Impairment Through Upregulating CRTC1 and Synaptophysin in Ischemic Stroke Rats. | Zhang X et al. | β | 2019 | β |
| Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy. | Morhenn K et al. | β | 2019 | β |
| Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. | Sonntag T et al. | β | 2019 | β |
| Non-canonical activation of CREB mediates neuroprotection in a Caenorhabditis elegans model of excitotoxic necrosis. | Feldmann KG et al. | β | 2019 | β |
| Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients. | DelacrΓ©taz A et al. | β | 2019 | β |
| A dual fluorescence reporter system for high throughput screening of effectors of <i>Kiss1</i> gene expression. | Li X et al. | β | 2018 | β |
| Exploring Genomic Variants Related to Residual Feed Intake in Local and Commercial Chickens by Whole Genomic Resequencing. | Liu J et al. | β | 2018 | β |
| Gene Level Regulation of Na,K-ATPase in the Renal Proximal Tubule Is Controlled by Two Independent but Interacting Regulatory Mechanisms Involving Salt Inducible Kinase 1 and CREB-Regulated Transcriptional Coactivators. | Taub M | β | 2018 | β |
| Non-Canonical Activation of CREB Mediates Neuroprotection in a<i>C. elegans</i>Model of Excitotoxic Necrosis | Feldmann KG et al. | β | 2018 | β |
| Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. | Turcot V et al. | β | 2018 | β |
| Regulation role of CRTC3 in skeletal muscle and adipose tissue. | Liu J et al. | β | 2018 | β |
| Structural Insights into the CRTC2-CREB Complex Assembly on CRE. | Song Y et al. | β | 2018 | β |
| Suppression of gluconeogenic gene transcription by SIK1-induced ubiquitination and degradation of CRTC1. | Gao WW et al. | β | 2018 | β |
| Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members. | Sonntag T et al. | β | 2017 | β |
| CRTC1 Function During Memory Encoding Is Disrupted in Neurodegeneration. | Parra-Damas A et al. | β | 2017 | β |
| CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation. | Quteineh L et al. | β | 2017 | β |
| Deregulation of CRTCs in Aging and Age-Related Disease Risk. | Escoubas CC et al. | β | 2017 | β |
| Disentangling puberty: novel neuroendocrine pathways and mechanisms for the control of mammalian puberty. | AvendaΓ±o MS et al. | β | 2017 | β |
| Emerging Roles of CREB-Regulated Transcription Coactivators in Brain Physiology and Pathology. | Saura CA et al. | β | 2017 | β |
| Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression. | Rossetti C et al. | β | 2017 | β |
| Kisspeptin level in the aging ovary is regulated by the sympathetic nervous system. | Fernandois D et al. | β | 2017 | β |
| The Role of NR2B-CREB-miR212/132-CRTC1-CREB Signal Network in Pain Regulation In Vitro and In Vivo. | Xia T et al. | β | 2017 | β |
| Bisphenol A induces hypothalamic down-regulation of the the cannabinoid receptor 1 and anorexigenic effects in male mice. | Suglia A et al. | β | 2016 | β |
| CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy. | Dubey D et al. | β | 2016 | β |
| Diet change and exercise enhance protein expression of CREB, CRTC 2 and lipolitic enzymes in adipocytes of obese mice. | Woo J et al. | β | 2016 | β |
| Dysregulated CRTC1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth. | Schumacher Y et al. | β | 2016 | β |
| Genome-wide association and identification of candidate genes for age at puberty in swine. | Nonneman DJ et al. | β | 2016 | β |
| Knock-in Luciferase Reporter Mice for In Vivo Monitoring of CREB Activity. | Akhmedov D et al. | β | 2016 | β |
| MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3. | Hallenborg P et al. | β | 2016 | β |
| New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. | Lu Y et al. | β | 2016 | β |
| Phoenixin Activates Immortalized GnRH and Kisspeptin Neurons Through the Novel Receptor GPR173. | Treen AK et al. | β | 2016 | β |
| Phosphodiesterase-4 inhibition as a therapeutic strategy for metabolic disorders. | Wu C et al. | β | 2016 | β |
| The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation. | Kim H | β | 2016 | β |
| Transcriptional regulation of the miR-212/miR-132 cluster in insulin-secreting Ξ²-cells by cAMP-regulated transcriptional co-activator 1 and salt-inducible kinases. | Malm HA et al. | β | 2016 | β |
| Cardiometabolic and reproductive benefits of early dietary energy restriction and voluntary exercise in an obese PCOS-prone rodent model. | Diane A et al. | β | 2015 | β |
| Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons. | Ch'ng TH et al. | β | 2015 | β |
| CREB pathway links PGE2 signaling with macrophage polarization. | Luan B et al. | β | 2015 | β |
| Insulin and Leptin Signaling Interact in the Mouse Kiss1 Neuron during the Peripubertal Period. | Qiu X et al. | β | 2015 | β |
| Leptin recruits Creb-regulated transcriptional coactivator 1 to improve hyperglycemia in insulin-deficient diabetes. | Kim GH et al. | β | 2015 | β |
| Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal. | Burkewitz K et al. | β | 2015 | β |
| Renal proximal tubule Na,K-ATPase is controlled by CREB-regulated transcriptional coactivators as well as salt-inducible kinase 1. | Taub M et al. | β | 2015 | β |
| Roles of leptin, adiponectin and resistin in the transcriptional regulation of steroidogenic genes contributing to decreased Leydig cells function in obesity. | Roumaud P et al. | β | 2015 | β |
| The adrenergic-regulated CRTC1 and CRTC2 phosphorylation and cellular distribution is independent of endogenous SIK1 in the male rat pinealocyte. | McTague J et al. | β | 2015 | β |
| The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. | Han J et al. | β | 2015 | β |
| A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity. | Pitman JL et al. | β | 2014 | β |
| Arginine methylation of CRTC2 is critical in the transcriptional control of hepatic glucose metabolism. | Han HS et al. | β | 2014 | β |
| Connecting metabolism and reproduction: roles of central energy sensors and key molecular mediators. | Roa J et al. | β | 2014 | β |
| Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages. | Parra-Damas A et al. | β | 2014 | β |
| CRTC2 activation in the suprachiasmatic nucleus, but not paraventricular nucleus, varies in a diurnal fashion and increases with nighttime light exposure. | Highland JA et al. | β | 2014 | β |
| Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. | Luan B et al. | β | 2014 | β |
| Minireview: Metabolic control of the reproductive physiology: insights from genetic mouse models. | Bellefontaine N et al. | β | 2014 | β |
| Region-specific activation of CRTC1-CREB signaling mediates long-term fear memory. | Nonaka M et al. | β | 2014 | β |
| The relationship between gut and adipose hormones, and reproduction. | Comninos AN et al. | β | 2014 | β |
| Transcriptional coregulators: fine-tuning metabolism. | Mouchiroud L et al. | β | 2014 | β |
| A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. | Levine DM et al. | β | 2013 | β |
| Brain response to calorie restriction. | Fusco S et al. | β | 2013 | β |
| FGF21 contributes to neuroendocrine control of female reproduction. | Owen BM et al. | β | 2013 | β |
| Genetic dissection of blood lipid traits by integrating genome-wide association study and gene expression profiling in a porcine model. | Chen C et al. | β | 2013 | β |
| Genetic risk for earlier menarche also influences peripubertal body mass index. | Johnson W et al. | β | 2013 | β |
| Genome-wide prediction of age at puberty and reproductive longevity in sows. | Tart JK et al. | β | 2013 | β |
| Implications of leptin in neuroendocrine regulation of male reproduction. | Landry D et al. | β | 2013 | β |
| Leptin signaling and circuits in puberty and fertility. | Elias CF et al. | β | 2013 | β |
| Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. | Asai M et al. | β | 2013 | β |
| Metabolic regulation of kisspeptin. | Castellano JM et al. | β | 2013 | β |
| Molecular, cellular, and structural mechanisms of cocaine addiction: a key role for microRNAs. | Jonkman S et al. | β | 2013 | β |
| Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice. | Singireddy AV et al. | β | 2013 | β |
| A bayesian translational framework for knowledge propagation, discovery, and integration under specific contexts. | Deng M et al. | β | 2012 | β |
| Activity-dependent transport of the transcriptional coactivator CRTC1 from synapse to nucleus. | Ch'ng TH et al. | β | 2012 | β |
| Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion. | Gu Y et al. | β | 2012 | β |
| A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction. | Fusco S et al. | β | 2012 | β |
| Deletion of CREB-regulated transcription coactivator 1 induces pathological aggression, depression-related behaviors, and neuroplasticity genes dysregulation in mice. | Breuillaud L et al. | β | 2012 | β |
| Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality. | Sekeres MJ et al. | β | 2012 | β |
| Kisspeptins and reproduction: physiological roles and regulatory mechanisms. | Pinilla L et al. | β | 2012 | β |
| Kisspeptins in human reproduction-future therapeutic potential. | Kaur KK et al. | β | 2012 | β |
| Leptin action in pubertal development: recent advances and unanswered questions. | Elias CF | β | 2012 | β |
| Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation. | Hallenborg P et al. | β | 2012 | β |
| Profile of Marc R. Montminy. | Zeliadt N | β | 2012 | β |
| A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells. | Kumagai A et al. | β | 2011 | β |
| Body mass index and fertility: is there a correlation with human reproduction outcomes? | Vilarino FL et al. | β | 2011 | β |
| CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. | Altarejos JY et al. | β | 2011 | β |
| CREB in adult neurogenesis--master and partner in the development of adult-born neurons? | Merz K et al. | β | 2011 | β |
| Kisspeptins in reproductive biology: consensus knowledge and recent developments. | Roa J et al. | β | 2011 | β |
| Lack of cAMP-response element-binding protein 1 in the hypothalamus causes obesity. | Chiappini F et al. | β | 2011 | β |
| Linking nutrition, maturation and aging: from thrifty genes to the spendthrift phenotype. | Stipp D | β | 2011 | β |
| Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. | Navarro VM et al. | β | 2011 | β |
| Regulation of the CREB coactivator TORC by the dual leucine zipper kinase at different levels. | Phu do T et al. | β | 2011 | β |
| Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. | Jeong H et al. | β | 2011 | β |
| beta-Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1. | EspaΓ±a J et al. | β | 2010 | β |
| Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells. | Martianov I et al. | β | 2010 | β |
| CRTC3 links catecholamine signalling to energy balance. | Song Y et al. | β | 2010 | β |
| Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. | Pospisilik JA et al. | β | 2010 | β |
| Energy balance and puberty onset: emerging role of central mTOR signaling. | Roa J et al. | β | 2010 | β |
| Kisspeptin/GPR54 system as potential target for endocrine disruption of reproductive development and function. | Tena-Sempere M | β | 2010 | β |
| Kisspeptins and the metabolic control of reproduction: physiologic roles and physiopathological implications. | Tena-Sempere M | β | 2010 | β |
| Kisspeptins: bridging energy homeostasis and reproduction. | Castellano JM et al. | β | 2010 | β |
| Kisspeptin signaling in the brain: recent developments and future challenges. | Tena-Sempere M | β | 2010 | β |
| Maturation of kisspeptinergic neurons coincides with puberty onset in male rats. | Bentsen AH et al. | β | 2010 | β |
| Metabolic control of puberty onset: new players, new mechanisms. | Roa J et al. | β | 2010 | β |
| Physiological roles of the kisspeptin/GPR54 system in the neuroendocrine control of reproduction. | Pineda R et al. | β | 2010 | β |
| Rimonabant (SR141716) induces metabolism and acquisition of fertilizing ability in human sperm. | Aquila S et al. | β | 2010 | β |
| Striatal microRNA controls cocaine intake through CREB signalling. | Hollander JA et al. | β | 2010 | β |
| The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke. | Liu L et al. | β | 2010 | β |
| Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. | Elks CE et al. | β | 2010 | β |
| TORC: a new twist on corticotropin-releasing hormone gene expression. | Spencer RL et al. | β | 2010 | β |
| Adult type 3 adenylyl cyclase-deficient mice are obese. | Wang Z et al. | β | 2009 | β |
| A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation. | Lerner RG et al. | β | 2009 | β |
| Brain-endocrine interactions: a microvascular route in the mediobasal hypothalamus. | Ciofi P et al. | β | 2009 | β |
| Mouse fertility is not dependent on the CREB coactivator Crtc1. | Breuillaud L et al. | β | 2009 | β |
| Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling. | Seo S et al. | β | 2009 | β |
| The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. | Roa J et al. | β | 2009 | β |
| TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons. | Li S et al. | β | 2009 | β |