Genetics of dopamine receptors and drug addiction: a comprehensive review.
paper
Cited
Public
Unavailable
- Authors
- Le Foll, Bernard; Gallo, Alexandra; Le Strat, Yann; Lu, Lin; Gorwood, Philip
- Year
- 2009
- Journal
- Behavioural pharmacology
- PMID
- 19179847
- DOI
- 10.1097/FBP.0b013e3283242f05
Drug dependence is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behaviours persist despite serious negative consequences. Addictive substances, such as opioids, ethanol, psychostimulants and nicotine, induce pleasant states or relieve distress, effects that contribute to their recreational use. Dopamine is critically involved in drug addiction processes. However, the role of the various dopaminergic receptor subtypes has been difficult to delineate. Here, we will review the information collected implicating the receptors of the D1 family (DRD1 and DRD5) and of the D2 family (DRD2, DRD3 and DRD4) in drug addiction. We will summarize the distribution of these receptors in the brain, the preclinical experiments carried out with pharmacological and transgenic approaches and the genetic studies carried out linking genetic variants of these receptors to drug addiction phenotypes. A meta-analysis of the studies carried out evaluating DRD2 and alcohol dependence is also provided, which indicates a significant association. Overall, this review indicates that different aspects of the addiction phenotype are critically influenced by dopaminergic receptors and that variants of those genes seem to influence some addiction phenotypes in humans.
No figures extracted from this document.
No chunks โ full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Artificial intelligence-based drug repurposing with electronic health record clinical corroboration: A case for ketamine as a potential treatment for amphetamine-type stimulant use disorder. | Gao Z et al. | โ | 2025 | โ |
| Associations Between Taq1A/C957T Polymorphic Variants and Autonomic Responsivity in a Slot Machine Task: Influence of Real-Life Gambling Exposure and Sex. | Hultman C et al. | โ | 2025 | โ |
| Demyelination in psychiatric and neurological disorders: Mechanisms, clinical impact, and novel therapeutic strategies. | Murayama R et al. | โ | 2025 | โ |
| DRD1 gene is associated with craving changes during withdrawal among patients with alcohol use disorder. | Lin ZY et al. | โ | 2025 | โ |
| Gut Microbiota and Dopamine: Producers, Consumers, Enzymatic Mechanisms, and In Vivo Insights. | Albani G et al. | โ | 2025 | โ |
| Reversible Antagonism of Dopamine D1 Receptor Using a Photoswitchable Remotely Tethered Ligand. | Hetzler BE et al. | โ | 2025 | โ |
| Understanding Intergenerational Transmission of Illicit Opioid Use Risk Based on Parent Drug Abuse History: Testing for Age-Graded Effects. | Wojciechowski T | โ | 2025 | โ |
| D2 dopamine receptor expression, reactivity to rewards, and reinforcement learning in a complex value-based decision-making task. | Banuelos C et al. | โ | 2024 | โ |
| Effects of Ketogenic Diet on Increased Ethanol Consumption Induced by Social Stress in Female Mice. | Torres-Rubio L et al. | โ | 2024 | โ |
| Evaluation of the Relationship Between Dopamine Receptor D2 Gene TaqIA1 Polymorphism and Alcohol Dependence Risk. | Kumar P et al. | โ | 2024 | โ |
| Genetic Variants Linked to Opioid Addiction: A Genome-Wide Association Study. | Panday SK et al. | โ | 2024 | โ |
| Molecular Mechanisms of Rett Syndrome: Emphasizing the Roles of Monoamine, Immunity, and Mitochondrial Dysfunction. | Gonรงalez JL et al. | โ | 2024 | โ |
| Polymorphisms in the Dopaminergic Receptor D3 Gene Correlate with Disease Progression Rate in Relapsing-Remitting Multiple Sclerosis Patients. | Ferrari M et al. | โ | 2024 | โ |
| Single Nucleotide Polymorphisms Within <i>DRD2, COMT, and DBH</i> and Smoking Cessation: A Systematic Review Considering Genetic Differences by Ancestry and Biological Sex. | Jones SK et al. | โ | 2024 | โ |
| Associated and intermediate factors between genetic variants of the dopaminergic D2 receptor gene and harmful alcohol use in young adults. | Mattioni J et al. | โ | 2023 | โ |
| End-to-end sequence-structure-function meta-learning predicts genome-wide chemical-protein interactions for dark proteins. | Cai T et al. | โ | 2023 | โ |
| Gaming disorder: A summary of its characteristics and aetiology. | Kirรกly O et al. | โ | 2023 | โ |
| Multiple solutions at the genomic level in response to selective breeding for high locomotor activity. | Hillis DA et al. | โ | 2023 | โ |
| Nanostructured wearable electrochemical and biosensor towards healthcare management: a review. | Khaleque MA et al. | โ | 2023 | โ |
| Potential of dietary hemp and cannabinoids to modulate immune response to enhance health and performance in animals: opportunities and challenges. | Hassan FU et al. | โ | 2023 | โ |
| The central blockade of the dopamine DR4 receptor decreases sucrose consumption by modifying the microstructure of drinking behavior in male rats. | Lรณpez-Alonso VE et al. | โ | 2023 | โ |
| The pleiotropic contribution of genes in dopaminergic and serotonergic pathways to addiction and related behavioral traits. | Antรณn-Galindo E et al. | โ | 2023 | โ |
| Association of Alcohol Use Disorder Risk With <i>ADH1B, DRD2, FAAH, SLC39A8, GCKR</i>, and <i>PDYN</i> Genetic Polymorphisms. | Legaki E et al. | โ | 2022 | โ |
| Association of Internet gaming disorder with catechol-O-methyltransferase: Role of impulsivity and fun-seeking. | Yen JY et al. | โ | 2022 | โ |
| Hypothesizing That Pediatric Autoimmune Neuropsychiatric Associated Streptococcal (PANDAS) Causes Rapid Onset of Reward Deficiency Syndrome (RDS) Behaviors and May Require Induction of "Dopamine Homeostasis". | Blum K et al. | โ | 2022 | โ |
| Tobacco and nicotine use. | Le Foll B et al. | โ | 2022 | โ |
| A Review of DNA Risk Alleles to Determine Epigenetic Repair of mRNA Expression to Prove Therapeutic Effectiveness in Reward Deficiency Syndrome (RDS): Embracing "Precision Behavioral Management". | Blum K et al. | โ | 2021 | โ |
| A systems omics-based approach to decode substance use disorders and neuroadaptations. | Veerappa A et al. | โ | 2021 | โ |
| Dopamine in Health and Disease: Much More Than a Neurotransmitter. | Franco R et al. | โ | 2021 | โ |
| How do stupendous cannabinoids modulate memory processing via affecting neurotransmitter systems? | Vaseghi S et al. | โ | 2021 | โ |
| Hyponatremia Following Antipsychotic Treatment: In Silico Pharmacodynamics Analysis of Spontaneous Reports From the US Food and Drug Administration Adverse Event Reporting System Database and an Updated Systematic Review. | Mazhar F et al. | โ | 2021 | โ |
| Individual Differences in Intertemporal Choice. | Keidel K et al. | โ | 2021 | โ |
| Neural mechanisms of credit card spending. | Banker S et al. | โ | 2021 | โ |
| Opioid Addiction and Opioid Receptor Dimerization: Structural Modeling of the OPRD1 and OPRM1 Heterodimer and Its Signaling Pathways. | Wu B et al. | โ | 2021 | โ |
| Psychostimulant use disorder emphasizing methamphetamine and the opioid -dopamine connection: Digging out of a hypodopaminergic ditch. | Blum K et al. | โ | 2021 | โ |
| Reviewing pharmacogenetics to advance precision medicine for opioids. | Magarbeh L et al. | โ | 2021 | โ |
| The Effects of Statins on Neurotransmission and Their Neuroprotective Role in Neurological and Psychiatric Disorders. | Kosowski M et al. | โ | 2021 | โ |
| The Neurobiology of Binge-eating Disorder Compared with Obesity: Implications for Differential Therapeutics. | Boswell RG et al. | โ | 2021 | โ |
| Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment? | Yang P et al. | โ | 2020 | โ |
| DRD4 polymorphisms modulate reward positivity and P3a in a gambling task: Exploring a genetic basis for cultural learning. | Glazer J et al. | โ | 2020 | โ |
| Exploring the role of the Ser9Gly (rs6280) Dopamine D3 receptor polymorphism in nicotine reinforcement and cue-elicited craving. | Chukwueke CC et al. | โ | 2020 | โ |
| Genetic Associations with Indoor Tanning Addiction among non-Hispanic White Young Adult Women. | Mays D et al. | โ | 2020 | โ |
| GPCR and Alcohol-Related Behaviors in Genetically Modified Mice. | Neasta J et al. | โ | 2020 | โ |
| Heroin delay discounting and impulsivity: Modulation by DRD1 genetic variation. | Moses TEH et al. | โ | 2020 | โ |
| Parental drinking according to parental composition and adolescent binge drinking: findings from a nationwide high school survey in Japan. | Inoura S et al. | โ | 2020 | โ |
| Behavioral Changes and Neuronal Damage in Rhesus Monkeys after 10 Weeks of Ketamine Administration Involve Prefrontal Cortex Dopamine D2 Receptor and Dopamine Transporter. | Sun Z et al. | โ | 2019 | โ |
| D-Amphetamine Exposure Differentially Disrupts Signaling Across Ontogeny in the Zebrafish. | Serpa BJ et al. | โ | 2019 | โ |
| Dopamine and addiction: what have we learned from 40ย years of research. | Solinas M et al. | โ | 2019 | โ |
| Genetic, Psychological, and Personal Network Factors Associated With Changes in Binge Drinking Over 2 Years Among Mexican Heritage Adolescents in the USA. | Song S et al. | โ | 2019 | โ |
| Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders. | Burns JA et al. | โ | 2019 | โ |
| Occupancy of dopamine D<sub>2</sub> and D<sub>3</sub> receptors by a novel D3 partial agonist BP1.4979: a [<sup>11</sup>C]-(+)-PHNO PET study in humans. | Di Ciano P et al. | โ | 2019 | โ |
| Role of eating disorders-related polymorphisms in obesity pathophysiology. | Nicoletti CF et al. | โ | 2019 | โ |
| The potential roles of dopamine in traumatic brain injury: a preclinical and clinical update. | Lan YL et al. | โ | 2019 | โ |
| Transcriptomic Characterization of the Human Insular Cortex and Claustrum. | Ibrahim C et al. | โ | 2019 | โ |
| A 35.8 kilobases haplotype spanning ANKK1 and DRD2 is associated with heroin dependence in Han Chinese males. | Zhang J et al. | โ | 2018 | โ |
| A Predictive Algorithm to Detect Opioid Use Disorder: What Is the Utility in a Primary Care Setting? | Lee C et al. | โ | 2018 | โ |
| A prospective, longitudinal study to evaluate the clinical utility of a predictive algorithm that detects risk of opioid use disorder. | Brenton A et al. | โ | 2018 | โ |
| Association study of BDNF and DRD3 genes with alcohol use disorder in Schizophrenia. | Zai CC et al. | โ | 2018 | โ |
| Dopamine D2 Receptors in Dopaminergic Neurons Modulate Performance in a Reversal Learning Task in Mice. | Linden J et al. | โ | 2018 | โ |
| Dopamine genes are linked to Extraversion and Neuroticism personality traits, but only in demanding climates. | Fischer R et al. | โ | 2018 | โ |
| Identification of Alkaloids from <i>Corydalis</i> <i>yanhusuo</i> W. T. Wang as Dopamine Dโ Receptor Antagonists by Using CRE-Luciferase Reporter Gene Assay. | Wu L et al. | โ | 2018 | โ |
| Manifesto for a European research network into Problematic Usage of the Internet. | Fineberg NA et al. | โ | 2018 | โ |
| Mapping of the prenatal and postnatal methamphetamine effects on D<sub>1</sub>-like dopamine, M<sub>1</sub> and M<sub>2</sub> muscarinic receptors in rat central nervous system. | Farar V et al. | โ | 2018 | โ |
| The factors associated with impulse control behaviors in Parkinson's disease: A 2-year longitudinal retrospective cohort study. | Kon T et al. | โ | 2018 | โ |
| The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users. | Batalla A et al. | โ | 2018 | โ |
| Understanding the implications of the biobehavioral basis of nicotine addiction and its impact on the efficacy of treatment. | Bozinoff N et al. | โ | 2018 | โ |
| A novel animal model for neuroinflammation and white matter degeneration. | Ji B et al. | โ | 2017 | โ |
| Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems. | Yeung EW et al. | โ | 2017 | โ |
| Current Concepts on the Physiopathological Relevance of Dopaminergic Receptors. | Ledonne A et al. | โ | 2017 | โ |
| Dopamine D<sub>4</sub> receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction. | Rivera A et al. | โ | 2017 | โ |
| Environmental risks outweigh dopaminergic genetic risks for alcohol use and abuse from adolescence through early adulthood. | Coley RL et al. | โ | 2017 | โ |
| Family history of alcoholism is related to increased D<sub>2</sub> /D<sub>3</sub> receptor binding potential: a marker of resilience or risk? | Alvanzo AA et al. | โ | 2017 | โ |
| Fractionating impulsivity: neuropsychiatric implications. | Dalley JW et al. | โ | 2017 | โ |
| Genetics of addictive behavior: the example of nicotine dependence. | Gorwood P et al. | โ | 2017 | โ |
| How Should Remote Clinical Monitoring Be Used to Treat Alcohol Use Disorders?: Initial Findings From an Expert Round Table Discussion. | Gordon A et al. | โ | 2017 | โ |
| Impact of SNP-SNP interaction among ABCB1, ARRB2, DRD1 and OPRD1 on methadone dosage requirement in Han Chinese patients. | Luo R et al. | โ | 2017 | โ |
| Internet addiction and its facets: The role of genetics and the relation to self-directedness. | Hahn E et al. | โ | 2017 | โ |
| Neurobiological findings related to Internet use disorders. | Park B et al. | โ | 2017 | โ |
| Neurotransmitter receptor genotypes associated with mental and behavioral disorders. | Varoglu E et al. | โ | 2017 | โ |
| Observational study to calculate addictive risk to opioids: a validation study of a predictive algorithm to evaluate opioid use disorder. | Brenton A et al. | โ | 2017 | โ |
| Polymorphisms of Dopamine Receptor Genes and Risk of L-Dopa-Induced Dyskinesia in Parkinson's Disease. | Comi C et al. | โ | 2017 | โ |
| Smoking and caffeine consumption: a genetic analysis of their association. | Treur JL et al. | โ | 2017 | โ |
| Systematic Review of Genetic Risk Factors for Sustaining a Mild Traumatic Brain Injury. | Panenka WJ et al. | โ | 2017 | โ |
| The Epigenetic Link between Prenatal Adverse Environments and Neurodevelopmental Disorders. | Kundakovic M et al. | โ | 2017 | โ |
| Validation Study of a Predictive Algorithm to Evaluate Opioid Use Disorder in a Primary Care Setting. | Sharma M et al. | โ | 2017 | โ |
| Association between genetic variation in the dopamine system and motor recovery after stroke. | Kim BR et al. | โ | 2016 | โ |
| Association study of DRD2 A2/A1, DRD3 Ser9Gly, DฮฒH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A polymorphisms with alcohol dependence. | Ragia G et al. | โ | 2016 | โ |
| Chemical Structure-Biological Activity Models for Pharmacophores' 3D-Interactions. | Putz MV et al. | โ | 2016 | โ |
| Dopamine D3 Receptors Modulate the Ability of Win-Paired Cues to Increase Risky Choice in a Rat Gambling Task. | Barrus MM et al. | โ | 2016 | โ |
| Dopamine receptor agonists modulate voluntary alcohol intake independently of individual levels of alcohol intake in rats. | Spoelder M et al. | โ | 2016 | โ |
| Dopamine receptor D2 and catechol-O-methyltransferase gene polymorphisms associated with anorexia nervosa in Chinese Han population: DRD2 and COMT gene polymorphisms were associated with AN. | Peng S et al. | โ | 2016 | โ |
| Dopaminergic drugs in type 2 diabetes and glucose homeostasis. | Lopez Vicchi F et al. | โ | 2016 | โ |
| Dopaminergic genetic variation moderates the effect of nicotine on cigarette reward. | Harrell PT et al. | โ | 2016 | โ |
| Effect of a D3 receptor antagonist on context-induced reinstatement of nicotine seeking. | Sabioni P et al. | โ | 2016 | โ |
| Fischer 344 and Lewis Rat Strains as a Model of Genetic Vulnerability to Drug Addiction. | Cadoni C | โ | 2016 | โ |
| Heritability of compulsive Internet use in adolescents. | Vink JM et al. | โ | 2016 | โ |
| High-dose alcohol intoxication differentially modulates cognitive subprocesses involved in response inhibition. | Stock AK et al. | โ | 2016 | โ |
| How close are we to individualized medicine for Parkinson's disease? | Kim HJ et al. | โ | 2016 | โ |
| Influence of Dopaminergic System Genetic Variation and Lifestyle Factors on Excessive Alcohol Consumption. | Celorrio D et al. | โ | 2016 | โ |
| Nicotinic cholinergic and dopaminergic receptor mRNA expression in male and female rats with high or low preference for nicotine. | Gozen O et al. | โ | 2016 | โ |
| Polymorphisms of dopamine receptor genes and risk of visual hallucinations in Parkinson's patients. | Ferrari M et al. | โ | 2016 | โ |
| What does addiction medicine expect from neuroscience? From genes and neurons to treatment responses. | Le Foll B | โ | 2016 | โ |
| Adding Genetic Testing to Evidence-Based Guidelines to Determine the Safest and Most Effective Chronic Pain Treatment for Injured Workers. | Meshkin B et al. | โ | 2015 | โ |
| Adenosinergic regulation of binge-like ethanol drinking and associated locomotor effects in male C57BL/6J mice. | Fritz BM et al. | โ | 2015 | โ |
| [A genetic view of addiction]. | Ramoz N et al. | โ | 2015 | โ |
| Altered regional brain volumes in elderly carriers of a risk variant for drug abuse in the dopamine D2 receptor gene (DRD2). | Roussotte FF et al. | โ | 2015 | โ |
| Cortico-striatal circuits: Novel therapeutic targets for substance use disorders. | Kravitz AV et al. | โ | 2015 | โ |
| Differential effects of dopamine-directed treatments on cognition. | Ashby FG et al. | โ | 2015 | โ |
| DRD4 and SLC6A3 gene polymorphisms are associated with food intake and nutritional status in children in early stages of development. | Fontana C et al. | โ | 2015 | โ |
| Dyskinesias and impulse control disorders in Parkinson's disease: From pathogenesis to potential therapeutic approaches. | Jimรฉnez-Urbieta H et al. | โ | 2015 | โ |
| Effects of enteral nutrition on the barrier function of the intestinal mucosa and dopamine receptor expression in rats with traumatic brain injury. | Zhang X et al. | โ | 2015 | โ |
| Evidence for limited D1 and D2 receptor coexpression and colocalization within the dorsal striatum of the neonatal mouse. | Biezonski DK et al. | โ | 2015 | โ |
| Influence of dopamine receptor gene polymorphisms on circulating T lymphocytes: A pilot study in healthy subjects. | Cosentino M et al. | โ | 2015 | โ |
| NCAM1-TTC12-ANKK1-DRD2 gene cluster and the clinical and genetic heterogeneity of adults with ADHD. | Mota NR et al. | โ | 2015 | โ |
| Peripheral and central effects of circulating catecholamines. | Tank AW et al. | โ | 2015 | โ |
| The epidemiology and genetics of binge eating disorder (BED). | Davis C | โ | 2015 | โ |
| The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice. | Sรธrensen G et al. | โ | 2015 | โ |
| The Impact of Selective Dopamine D2, D3 and D4 Ligands on the Rat Gambling Task. | Di Ciano P et al. | โ | 2015 | โ |
| Trait sexual motivation questionnaire: concept and validation. | Stark R et al. | โ | 2015 | โ |
| Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions. | Ma Y et al. | โ | 2015 | โ |
| Addiction and reward-related genes show altered expression in the postpartum nucleus accumbens. | Zhao C et al. | โ | 2014 | โ |
| Addiction science: Uncovering neurobiological complexity. | Volkow ND et al. | โ | 2014 | โ |
| Anterior ventral tegmental area dopaminergic neurons are not involved in the motivational effects of bromocriptine, pramipexole and cocaine in drug-free rats. | Ouachikh O et al. | โ | 2014 | โ |
| A selective role for dopamine Dโ receptors in modulating reward expectancy in a rodent slot machine task. | Cocker PJ et al. | โ | 2014 | โ |
| Can Substance Use Disorders be Managed Using the Chronic Care Model? Review and Recommendations from a NIDA Consensus Group. | McLellan AT et al. | โ | 2014 | โ |
| Dopamine D3 receptor ligands for drug addiction treatment: update on recent findings. | Le Foll B et al. | โ | 2014 | โ |
| Dopamine D4 receptors in psychostimulant addiction. | Di Ciano P et al. | โ | 2014 | โ |
| Dopaminergic pathway polymorphisms and heroin addiction: further support for association of CSNK1E variants. | Levran O et al. | โ | 2014 | โ |
| DRD1 and DRD2 genotypes modulate processing modes of goal activation processes during action cascading. | Stock AK et al. | โ | 2014 | โ |
| Elevation of dopamine induced by cigarette smoking: novel insights from a [11C]-+-PHNO PET study in humans. | Le Foll B et al. | โ | 2014 | โ |
| Hydroxymethylation and DNA methylation profiles in the prefrontal cortex of the non-human primate rhesus macaque and the impact of maternal deprivation on hydroxymethylation. | Massart R et al. | โ | 2014 | โ |
| Modest long-term ethanol consumption affects expression of neurotransmitter receptor genes in the rat nucleus accumbens. | Jonsson S et al. | โ | 2014 | โ |
| Orquestic regulation of neurotransmitters on reward-seeking behavior. | Arias-Carriรณn O et al. | โ | 2014 | โ |
| Recent methods for measuring dopamine D3 receptor occupancy in vivo: importance for drug development. | Le Foll B et al. | โ | 2014 | โ |
| Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility. | Guigas B et al. | โ | 2014 | โ |
| Addictive behaviors and addiction-prone personality traits: associations with a dopamine multilocus genetic profile. | Davis C et al. | โ | 2013 | โ |
| Advances in genetic studies of substance abuse in China. | Sun Y et al. | โ | 2013 | โ |
| Advancing transdisciplinary translation for prevention of high-risk behaviors: introduction to the special issue. | Fishbein DH et al. | โ | 2013 | โ |
| A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence. | Wang F et al. | โ | 2013 | โ |
| Case-control association analysis of dopamine receptor polymorphisms in alcohol dependence: a pilot study in Indian males. | Prasad P et al. | โ | 2013 | โ |
| COMT Val158Met modulates the effect of childhood adverse experiences on the risk of alcohol dependence. | Schellekens AF et al. | โ | 2013 | โ |
| Differential behavioral reinforcement effects of dopamine receptor agonists in the rat with bilateral lesion of the posterior ventral tegmental area. | Ouachikh O et al. | โ | 2013 | โ |
| Dopamine receptor D1 and postsynaptic density gene variants associate with opiate abuse and striatal expression levels. | Jacobs MM et al. | โ | 2013 | โ |
| From passive overeating to "food addiction": a spectrum of compulsion and severity. | Davis C | โ | 2013 | โ |
| Genetic variants associated with addictive behavior in Colombian addicted and non-addicted to heroin or cocaine. | Isaza C et al. | โ | 2013 | โ |
| Genetic variation in the human brain dopamine system influences motor learning and its modulation by L-Dopa. | Pearson-Fuhrhop KM et al. | โ | 2013 | โ |
| HIV-related cognitive impairment shows bi-directional association with dopamine receptor DRD1 and DRD2 polymorphisms in substance-dependent and substance-independent populations. | Jacobs MM et al. | โ | 2013 | โ |
| Individual variation in resisting temptation: implications for addiction. | Saunders BT et al. | โ | 2013 | โ |
| Modification of cocaine self-administration by buspirone (busparยฎ): potential involvement of D3 and D4 dopamine receptors. | Bergman J et al. | โ | 2013 | โ |
| Peroxisome proliferator-activated receptor (PPAR) agonists as promising new medications for drug addiction: preclinical evidence. | Le Foll B et al. | โ | 2013 | โ |
| Polymorphic variation in the dopamine D4 receptor predicts delay discounting as a function of childhood socioeconomic status: evidence for differential susceptibility. | Sweitzer MM et al. | โ | 2013 | โ |
| Repeated cocaine exposure increases fast-spiking interneuron excitability in the rat medial prefrontal cortex. | Campanac E et al. | โ | 2013 | โ |
| Repurposing buspirone for drug addiction treatment. | Le Foll B et al. | โ | 2013 | โ |
| Shared and unique genetic contributions to attention deficit/hyperactivity disorder and substance use disorders: a pilot study of six candidate genes. | Carpentier PJ et al. | โ | 2013 | โ |
| Suboxone misuse along the opiate maintenance treatment pathway. | Furst RT | โ | 2013 | โ |
| Substance use disorders: a theory-driven approach to the integration of genetics and neuroimaging. | Karoly HC et al. | โ | 2013 | โ |
| Tentative evidence for striatal hyperactivity in adolescent cannabis-using boys: a cross-sectional multicenter fMRI study. | Jager G et al. | โ | 2013 | โ |
| The adenosine A2A receptor agonist CGS 21680 decreases ethanol self-administration in both non-dependent and dependent animals. | Houchi H et al. | โ | 2013 | โ |
| The association between DRD2/ANKK1 and genetically informed measures of alcohol use and problems. | Meyers JL et al. | โ | 2013 | โ |
| The dopamine receptor D1 gene is associated with the length of interval between first heroin use and onset of dependence in Chinese Han heroin addicts. | Peng S et al. | โ | 2013 | โ |
| The epigenetic effect of nicotine on dopamine D1 receptor expression in rat prefrontal cortex. | Gozen O et al. | โ | 2013 | โ |
| The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. | Hess ME et al. | โ | 2013 | โ |
| The potential role of dopamine Dโ receptor neurotransmission in cognition. | Nakajima S et al. | โ | 2013 | โ |
| The role of dopaminergic transmission through D1-like and D2-like receptors in amphetamine-induced rat ultrasonic vocalizations. | Wright JM et al. | โ | 2013 | โ |
| Understanding Youth Antisocial Behavior Using Neuroscience through a Developmental Psychopathology Lens: Review, Integration, and Directions for Research. | Hyde LW et al. | โ | 2013 | โ |
| Analysis of dopamine D2 receptor (DRD2) gene polymorphisms in cannabinoid addicts. | Nacak M et al. | โ | 2012 | โ |
| A neurocomputational account of cognitive deficits in Parkinson's disease. | Hรฉlie S et al. | โ | 2012 | โ |
| A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. | Beaulieu JM | โ | 2012 | โ |
| Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers. | Zhang XY et al. | โ | 2012 | โ |
| Blockade of dopamine d4 receptors attenuates reinstatement of extinguished nicotine-seeking behavior in rats. | Yan Y et al. | โ | 2012 | โ |
| Bridging Animal and Human Models: Translating From (and to) Animal Genetics. | Barkley-Levenson AM et al. | โ | 2012 | โ |
| Cannabis-dependence risk relates to synergism between neuroticism and proenkephalin SNPs associated with amygdala gene expression: case-control study. | Jutras-Aswad D et al. | โ | 2012 | โ |
| Direct-to-consumer genetic testing for addiction susceptibility: a premature commercialisation of doubtful validity and value. | Mathews R et al. | โ | 2012 | โ |
| Dopamine D(2) Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly. | Ejendal KF et al. | โ | 2012 | โ |
| Dopamine-system genes, childhood abuse, and clinical manifestations in women with Bulimia-Spectrum Disorders. | Groleau P et al. | โ | 2012 | โ |
| DRD2 C957T and TaqIA genotyping reveals gender effects and unique low-risk and high-risk genotypes in alcohol dependence. | Swagell CD et al. | โ | 2012 | โ |
| DRD4 polymorphism moderates the effect of alcohol consumption on social bonding. | Creswell KG et al. | โ | 2012 | โ |
| Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating- and personality-related psychopathology. | Thaler L et al. | โ | 2012 | โ |
| Frequency of gambling problems among parents of pathological, versus nonpathological, casino gamblers using slot machines. | Versini A et al. | โ | 2012 | โ |
| Genetics of dopamine receptors and drug addiction. | Gorwood P et al. | โ | 2012 | โ |
| Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking. | Mutschler J et al. | โ | 2012 | โ |
| Genetic variations in the dopaminergic system and alcohol use: a system-level analysis. | Chen C et al. | โ | 2012 | โ |
| Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice. | Bahi A et al. | โ | 2012 | โ |
| Linking dopamine neurotransmission and neurogenesis: The evolutionary history of the NTAD (NCAM1-TTC12-ANKK1-DRD2) gene cluster. | Mota NR et al. | โ | 2012 | โ |
| Pathological Gambling: Neuropsychopharmacology and Treatment. | Bullock SA et al. | โ | 2012 | โ |
| Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network. | Le Merrer J et al. | โ | 2012 | โ |
| Systematic analysis of dopamine receptor genes (DRD1-DRD5) in antipsychotic-induced weight gain. | Mรผller DJ et al. | โ | 2012 | โ |
| The role of ANKK1 and TTC12 genes on drinking behaviour in tobacco dependent subjects. | Lobo DS et al. | โ | 2012 | โ |
| Tridimensional personalities and polymorphism of dopamine D2 receptor among heroin addicts. | Teh LK et al. | โ | 2012 | โ |
| Correlated genotypes in friendship networks. | Fowler JH et al. | โ | 2011 | โ |
| Distribution measurement of amphetamine-type stimulants in organs using micropulverized extraction and liquid chromatography/tandem mass spectrometry to complement drug distribution using mass spectrometry imaging. | Kuwayama K et al. | โ | 2011 | โ |
| Do alcohol-dependent individuals with DRD2 A1 allele have an increased risk of relapse? A pilot study. | Dahlgren A et al. | โ | 2011 | โ |
| Dopamine and learned food preferences. | Sclafani A et al. | โ | 2011 | โ |
| Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers. | Breitling LP et al. | โ | 2011 | โ |
| Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain. | McGeary JE et al. | โ | 2011 | โ |
| Effects of premature birth on the risk for alcoholism appear to be greater in males than females. | Manzardo AM et al. | โ | 2011 | โ |
| Exploring functional polymorphisms in the dopamine receptor D2 gene using prolactin concentration in healthy subjects. | Fukui N et al. | โ | 2011 | โ |
| Genetic factors of reaction time performance: DRD4 7-repeat allele associated with slower responses. | Szekely A et al. | โ | 2011 | โ |
| Genetic vulnerability and susceptibility to substance dependence. | Bierut LJ | โ | 2011 | โ |
| Individual differences in schedule-induced polydipsia: neuroanatomical dopamine divergences. | Pellรณn R et al. | โ | 2011 | โ |
| Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse. | Moyer RA et al. | โ | 2011 | โ |
| Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). | Hack LM et al. | โ | 2011 | โ |
| Maternal cannabis use alters ventral striatal dopamine D2 gene regulation in the offspring. | DiNieri JA et al. | โ | 2011 | โ |
| Molecular mechanisms of maternal cannabis and cigarette use on human neurodevelopment. | Morris CV et al. | โ | 2011 | โ |
| Neurogenetics and clinical evidence for the putative activation of the brain reward circuitry by a neuroadaptagen: proposing an addiction candidate gene panel map. | Chen TJ et al. | โ | 2011 | โ |
| New operant model of reinstatement of food-seeking behavior in mice. | Martรญn-Garcรญa E et al. | โ | 2011 | โ |
| Opiates, overeating and obesity: a psychogenetic analysis. | Davis C et al. | โ | 2011 | โ |
| Peripheral biomarkers of cognitive response to dopamine receptor agonist treatment. | Ersche KD et al. | โ | 2011 | โ |
| Pharmacogenetics of leptin in antipsychotic-associated weight gain and obesity-related complications. | Lee AK et al. | โ | 2011 | โ |
| PharmGKB summary: dopamine receptor D2. | Mi H et al. | โ | 2011 | โ |
| Phenothiazine: the seven lives of pharmacology's first lead structure. | Ohlow MJ et al. | โ | 2011 | โ |
| Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. | Nemoda Z et al. | โ | 2011 | โ |
| The effect of the OPRM1 and DRD4 polymorphisms on the relation between attentional bias and alcohol use in adolescence and young adulthood. | Pieters S et al. | โ | 2011 | โ |
| The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing. | Seif T et al. | โ | 2011 | โ |
| The physiology, signaling, and pharmacology of dopamine receptors. | Beaulieu JM et al. | โ | 2011 | โ |
| Threshold of adulthood for the onset of nicotine self-administration in male and female rats. | Levin ED et al. | โ | 2011 | โ |
| A caged nicotine with nanosecond range kinetics and visible light sensitivity. | Filevich O et al. | โ | 2010 | โ |
| A functional fast scan cyclic voltammetry assay to characterize dopamine D2 and D3 autoreceptors in the mouse striatum. | Maina FK et al. | โ | 2010 | โ |
| Association of DRD2 variants and Gilles de la Tourette syndrome in a family-based sample from a South American population isolate. | Herzberg I et al. | โ | 2010 | โ |
| Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia. | Novak G et al. | โ | 2010 | โ |
| A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors. | Jeon J et al. | โ | 2010 | โ |
| Dopaminergic modulation of cognition across the life span. | Li SC et al. | โ | 2010 | โ |
| Genetic variation in three candidate genes and nicotine dependence, withdrawal and smoking cessation in hospitalized patients. | De Ruyck K et al. | โ | 2010 | โ |
| In alcohol-dependent drinkers, what does the presence of nicotine dependence tell us about psychiatric and addictive disorders comorbidity? | Le Strat Y et al. | โ | 2010 | โ |
| Measuring addiction propensity and severity: the need for a new instrument. | Conway KP et al. | โ | 2010 | โ |
| Opioid-dopamine interactions: implications for substance use disorders and their treatment. | Volkow ND | โ | 2010 | โ |
| Pharmacogenetics of D2 dopamine receptor gene in prolactin-secreting pituitary adenomas. | Filopanti M et al. | โ | 2010 | โ |
| Tonic dopamine modulates exploitation of reward learning. | Beeler JA et al. | โ | 2010 | โ |
| Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: a preliminary study. | Novak G et al. | โ | 2009 | โ |
| A systems biology network model for genetic association studies of nicotine addiction and treatment. | Thomas PD et al. | โ | 2009 | โ |
| [Comorbidity of substance use disorders and attention-deficit hyperactivity disorders: pathogenesis and therapy]. | Fallgatter AJ et al. | โ | 2009 | โ |
| New insights into the genetics of addiction. | Li MD et al. | โ | 2009 | โ |
| Potential association of DRD2 and DAT1 genetic variation with heroin dependence. | Hou QF et al. | โ | 2009 | โ |
| Prediction of deleterious non-synonymous single nucleotide polymorphisms of genes related to ethanol-induced toxicity. | Wang LL et al. | โ | 2009 | โ |