New approaches to population stratification in genome-wide association studies.
paper
Cited
Public
- Authors
- Price, Alkes L; Zaitlen, Noah A; Reich, David; Patterson, Nick
- Year
- 2010
- Journal
- Nature reviews. Genetics
- PMID
- 20548291
- DOI
- 10.1038/nrg2813
- PMCID
- PMC2975875
Genome-wide association (GWA) studies are an effective approach for identifying genetic variants associated with disease risk. GWA studies can be confounded by population stratification--systematic ancestry differences between cases and controls--which has previously been addressed by methods that infer genetic ancestry. Those methods perform well in data sets in which population structure is the only kind of structure present but are inadequate in data sets that also contain family structure or cryptic relatedness. Here, we review recent progress on methods that correct for stratification while accounting for these additional complexities.
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|---|---|---|---|---|
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| Genetic Parameter Estimation and Genome-Wide Association Study-Based Loci Identification of Milk-Related Traits in Chinese Holstein. | Lu X et al. | β | 2021 | β |
| Genetic substructure and complex demographic history of South African Bantu speakers. | Sengupta D et al. | β | 2021 | β |
| Genetic variants in S-adenosyl-methionine synthesis pathway and nonsyndromic cleft lip with or without cleft palate in Chile. | Salamanca C et al. | β | 2021 | β |
| Genome Divergence and Dynamics in the Thin-Tailed Desert Sheep From Sudan. | Abied A et al. | β | 2021 | β |
| Genome-wide association mapping for grain manganese in rice (Oryza sativa L.) using a multi-experiment approach. | Ruang-Areerate P et al. | β | 2021 | β |
| Genome-Wide Association Studies for the Detection of Genetic Variants Associated With Daptomycin and Ceftaroline Resistance in <i>Staphylococcus aureus</i>. | Weber RE et al. | β | 2021 | β |
| Genome-Wide Association Study Candidate Genes on Mammary System-Related Teat-Shape Conformation Traits in Chinese Holstein Cattle. | Nazar M et al. | β | 2021 | β |
| Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia. | Liu J et al. | β | 2021 | β |
| Genome-Wide Association Study Identifies Candidate Genes Associated with Feet and Leg Conformation Traits in Chinese Holstein Cattle. | Abdalla IM et al. | β | 2021 | β |
| Genome-Wide Association Study Identifies First Locus Associated with Susceptibility to Cerebral Venous Thrombosis. | Ken-Dror G et al. | β | 2021 | β |
| Genome-Wide Association Study of Growth Performance and Immune Response to Newcastle Disease Virus of Indigenous Chicken in Rwanda. | Habimana R et al. | β | 2021 | β |
| Genome-wide association study of pancreatic fat: The Multiethnic Cohort Adiposity Phenotype Study. | Streicher SA et al. | β | 2021 | β |
| Genome-Wide Association Study on Reproduction-Related Body-Shape Traits of Chinese Holstein Cows. | Lu X et al. | β | 2021 | β |
| Genomic analysis of ionome-related QTLs in Arabidopsis thaliana. | Shariatipour N et al. | β | 2021 | β |
| Genomic Regions Related to White/Black Tail Feather Color in Dwarf Chickens Identified Using a Genome-Wide Association Study. | Nie C et al. | β | 2021 | β |
| Genomics of Endometriosis: From Genome Wide Association Studies to Exome Sequencing. | Lalami I et al. | β | 2021 | β |
| Ghost QTL and hotspots in experimental crosses: novel approach for modeling polygenic effects. | Wallin J et al. | β | 2021 | β |
| Identification of candidate genomic regions for chicken egg number traits based on genome-wide association study. | Zhao X et al. | β | 2021 | β |
| Identifying Anti-Oxidant Biosynthesis Genes in Pearl Millet [<i>Pennisetum glaucum</i> (L.) R. Br.] Using Genome-Wide Association Analysis. | Yadav CB et al. | β | 2021 | β |
| Infertility due to defective sperm flagella caused by an intronic deletion in DNAH17 that perturbs splicing. | NoskovΓ‘ A et al. | β | 2021 | β |
| Innovative approach to identify multigenomic and environmental interactions associated with birth defects in family-based hybrid designs. | Lou XY et al. | β | 2021 | β |
| Insight into the Candidate Genes and Enriched Pathways Associated with Height, Length, Length to Height Ratio and Body-Weight of Korean Indigenous Breed, Jindo Dog Using Gene Set Enrichment-Based GWAS Analysis. | Sheet S et al. | β | 2021 | β |
| Investigating asthma heterogeneity through shared and distinct genetics: Insights from genome-wide cross-trait analysis. | Zhu Z et al. | β | 2021 | β |
| Loci identified by a genome-wide association study of carotid artery stenosis in the eMERGE network. | Palmer MR et al. | β | 2021 | β |
| Mapping the 17q12-21.1 Locus for Variants Associated with Early-Onset Asthma in African Americans. | Gui H et al. | β | 2021 | β |
| Maternal genotypes of folate/one-carbon metabolism gene variants and nonsyndromic cleft lip with or without cleft palate risk in Chile. | Inostroza V et al. | β | 2021 | β |
| Mendelian randomization study shows no causal effects of serum urate levels on the risk of MS. | Harroud A et al. | β | 2021 | β |
| Multidimensional Approach Assessing the Role of Interleukin 1 Beta in Mesial Temporal Lobe Epilepsy. | Santos RO et al. | β | 2021 | β |
| Multi-omic analysis elucidates the genetic basis of hydrocephalus. | Hale AT et al. | β | 2021 | β |
| Multi-scale inference of genetic trait architecture using biologically annotated neural networks. | Demetci P et al. | β | 2021 | β |
| Multivariate Analysis and Modelling of multiple Brain endOphenotypes: Let's MAMBO! | Vilor-Tejedor N et al. | β | 2021 | β |
| Multivariate GWAS of Structural Dental Anomalies and Dental Caries in a Multi-Ethnic Cohort. | Alotaibi RN et al. | β | 2021 | β |
| NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori. | Gonzalez-Hormazabal P et al. | β | 2021 | β |
| Pediatric anxiety associated with altered facial emotion recognition. | Rappaport LM et al. | β | 2021 | β |
| Performance of model-based multifactor dimensionality reduction methods for epistasis detection by controlling population structure. | Abegaz F et al. | β | 2021 | β |
| Pleiotropic Loci Associated With Foot Disorders and Common Periparturient Diseases in Holstein Cattle. | Lai E et al. | β | 2021 | β |
| PopInf: An Approach for Reproducibly Visualizing and Assigning Population Affiliation in Genomic Samples of Uncertain Origin. | Taravella Oill AM et al. | β | 2021 | β |
| Population genomics of selectively neutral genetic structure and herbicide resistance in UK populations of Alopecurus myosuroides. | Dixon A et al. | β | 2021 | β |
| Population Structure Limits Parallel Evolution in Sticklebacks. | Fang B et al. | β | 2021 | β |
| Principal components for morphometric traits in Campolina horses. | Solar Diaz IDP et al. | β | 2021 | β |
| QTL Mapping and GWAS Reveal the Genetic Mechanism Controlling Soluble Solids Content in <i>Brassica napus</i> Shoots. | Wu X et al. | β | 2021 | β |
| Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration. | Zhou L et al. | β | 2021 | β |
| Rare Coding Variants Associated with Breast Cancer. | Han MR | β | 2021 | β |
| Recommendations for Statistical Reporting in Cardiovascular Medicine: A Special Report From the American Heart Association. | Althouse AD et al. | β | 2021 | β |
| Sex differences in deleterious mutational effects in Drosophila melanogaster: combining quantitative and population genetic insights. | Ruzicka F et al. | β | 2021 | β |
| The distribution of common-variant effect sizes. | O'Connor LJ | β | 2021 | β |
| The genomics of rapid climatic adaptation and parallel evolution in North American house mice. | Ferris KG et al. | β | 2021 | β |
| Toward identification of a putative candidate gene for nutrient mineral accumulation in wheat grains for human nutrition purposes. | Alomari DZ et al. | β | 2021 | β |
| White Matter Integrity and Nicotine Dependence: Evaluating Vertical and Horizontal Pleiotropy. | Ye Z et al. | β | 2021 | β |
| Whole-genome sequence analysis unveils different origins of European and Asiatic mouflon and domestication-related genes in sheep. | Chen ZH et al. | β | 2021 | β |
| A consistent approach to the genotype encoding problem in a genome-wide association study of continuous phenotypes. | Kim S et al. | β | 2020 | β |
| A genome-wide association study of reproduction traits in four pig populations with different genetic backgrounds. | Jiang Y et al. | β | 2020 | β |
| Aggression based genome-wide, glutamatergic, dopaminergic and neuroendocrine polygenic risk scores predict callous-unemotional traits. | Ruisch IH et al. | β | 2020 | β |
| An evaluation of machine-learning for predicting phenotype: studies in yeast, rice, and wheat. | Grinberg NF et al. | β | 2020 | β |
| A road map for understanding molecular and genetic determinants of osteoporosis. | Yang TL et al. | β | 2020 | β |
| Association Between IRF6 Variants and Nonsyndromic Cleft Lip With or Without Cleft Palate in Chile. | Suazo J et al. | β | 2020 | β |
| Association between polygenic liability for schizophrenia and substance involvement: A nationwide population-based study in Taiwan. | Wang SH et al. | β | 2020 | β |
| Beyond large-effect loci: large-scale GWAS reveals a mixed large-effect and polygenic architecture for age at maturity of Atlantic salmon. | Sinclair-Waters M et al. | β | 2020 | β |
| Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model. | Holland D et al. | β | 2020 | β |
| Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium. | HΓ€ssler S et al. | β | 2020 | β |
| Diet Quality and Food Prices Modify Associations between Genetic Susceptibility to Obesity and Adiposity Outcomes. | Han HY et al. | β | 2020 | β |
| Eagle: multi-locus association mapping on a genome-wide scale made routine. | George AW et al. | β | 2020 | β |
| Educational attainment polygenic scores are associated with cortical total surface area and regions important for language and memory. | Mitchell BL et al. | β | 2020 | β |
| Efficient toolkit implementing best practices for principal component analysis of population genetic data. | PrivΓ© F et al. | β | 2020 | β |
| Embracing study heterogeneity for finding genetic interactions in large-scale research consortia. | Liu Y et al. | β | 2020 | β |
| Evaluation of population stratification adjustment using genome-wide or exonic variants. | Chen Y et al. | β | 2020 | β |
| Evaluation of the Precision of Ancestry Inferences in South American Admixed Populations. | Pereira V et al. | β | 2020 | β |
| Evolutionary perspectives on polygenic selection, missing heritability, and GWAS. | Uricchio LH | β | 2020 | β |
| Fine-scale population structure in the UK Biobank: implications for genome-wide association studies. | Cook JP et al. | β | 2020 | β |
| Gene association detection via local linear regression method. | He J et al. | β | 2020 | β |
| Gene-Based Association Mapping for Dental Caries in The GENEVA Consortium. | Wang Y et al. | β | 2020 | β |
| Genetically predicted telomere length is associated with clonal somatic copy number alterations in peripheral leukocytes. | Brown DW et al. | β | 2020 | β |
| Genetic and phenotypic evidence of a contact zone between divergent colour morphs of the iconic red-eyed treefrog. | Akopyan M et al. | β | 2020 | β |
| Genetic Association and Expression Correlation between Colony-Stimulating Factor 1 Gene Encoding M-CSF and Adult-Onset Still's Disease. | Chen YM et al. | β | 2020 | β |
| Genetic components of root architecture and anatomy adjustments to water-deficit stress in spring barley. | Oyiga BC et al. | β | 2020 | β |
| Genome-Wide Association for Itraconazole Sensitivity in Non-resistant Clinical Isolates of <i>Aspergillus fumigatus</i>. | Zhao S et al. | β | 2020 | β |
| Genome-Wide Association Studies for the Concentration of Albumin in Colostrum and Serum in Chinese Holstein. | Lin S et al. | β | 2020 | β |
| Genome-Wide Association Study of Body Weight Traits in Chinese Fine-Wool Sheep. | Lu Z et al. | β | 2020 | β |
| Genome-wide association study of shank length and diameter at different developmental stages in chicken F2 resource population. | Emrani H et al. | β | 2020 | β |
| Genome-Wide Association Study of Sleep Disturbances in Depressive Disorders. | Melhuish Beaupre LM et al. | β | 2020 | β |
| Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents. | Docherty AR et al. | β | 2020 | β |
| Genome-wide association study uncovers genomic regions associated with grain iron, zinc and protein content in pearl millet. | Pujar M et al. | β | 2020 | β |
| Host and symbiont genetic determinants of nutritional phenotype in a natural population of the pea aphid. | Chung SH et al. | β | 2020 | β |
| Identification of Novel Genes Associated with Cortical Thickness in Alzheimer's Disease: Systems Biology Approach to Neuroimaging Endophenotype. | Kim BH et al. | β | 2020 | β |
| Inbreeding depression across the genome of Dutch Holstein Friesian dairy cattle. | Doekes HP et al. | β | 2020 | β |
| In the presence of population structure: From genomics to candidate genes underlying local adaptation. | Price N et al. | β | 2020 | β |
| Mixed logistic regression in genome-wide association studies. | Milet J et al. | β | 2020 | β |
| Modeling the Dependence Structure in Genome Wide Association Studies of Binary Phenotypes in Family Data. | Seal S et al. | β | 2020 | β |
| Nested association mapping of important agronomic traits in three interspecific soybean populations. | Beche E et al. | β | 2020 | β |
| No Evidence for Social Genetic Effects or Genetic Similarity Among Friends Beyond that Due to Population Stratification: A Reappraisal of Domingue et al (2018). | Yengo L et al. | β | 2020 | β |
| On rare variants in principal component analysis of population stratification. | Ma S et al. | β | 2020 | β |
| Optimal selection of genetic variants for adjustment of population stratification in European association studies. | Brinster R et al. | β | 2020 | β |
| Polygenic Risk Scores for Developmental Disorders, Neuromotor Functioning During Infancy, and Autistic Traits in Childhood. | Serdarevic F et al. | β | 2020 | β |
| Quantifying Differences in Heritability among Psoriatic Arthritis (PsA), Cutaneous Psoriasis (PsC) and Psoriasis vulgaris (PsV). | Li Q et al. | β | 2020 | β |
| Recommendations for Choosing the Genotyping Method and Best Practices for Quality Control in Crop Genome-Wide Association Studies. | Pavan S et al. | β | 2020 | β |
| Resource conservation manifests in the genetic code. | Shenhav L et al. | β | 2020 | β |
| Scalable probabilistic PCA for large-scale genetic variation data. | Agrawal A et al. | β | 2020 | β |
| Statistical genomics in rare cancer. | Abbas-Aghababazadeh F et al. | β | 2020 | β |
| The impact of disregarding family structure on genome-wide association analysis of complex diseases in cohorts with simple pedigrees. | Nazarian A et al. | β | 2020 | β |
| The relationship of genetic susceptibilities for psychosis with physiological fluctuation in functional MRI data. | Saarinen A et al. | β | 2020 | β |
| The Relative Contributions of Socioeconomic and Genetic Factors to Variations in Body Mass Index Among Young Adults. | Kim R et al. | β | 2020 | β |
| The search for sexually antagonistic genes: Practical insights from studies of local adaptation and statistical genomics. | Ruzicka F et al. | β | 2020 | β |
| Tutorial: a guide to performing polygenic risk score analyses. | Choi SW et al. | β | 2020 | β |
| Variance heterogeneity genome-wide mapping for cadmium in bread wheat reveals novel genomic loci and epistatic interactions. | Hussain W et al. | β | 2020 | β |
| Whole-genome analyses identify loci and selective signals associated with body size in cattle. | Chen Q et al. | β | 2020 | β |
| Accurate ethnicity prediction from placental DNA methylation data. | Yuan V et al. | β | 2019 | β |
| A functional macrophage migration inhibitory factor promoter polymorphism is associated with reduced diffusing capacity. | Zhang C et al. | β | 2019 | β |
| A linear mixed model approach to gene expression-tumor aneuploidy association studies. | Yao DW et al. | β | 2019 | β |
| A panel of 32 AIMs suitable for population stratification correction and global ancestry estimation in Mexican mestizos. | Huerta-Chagoya A et al. | β | 2019 | β |
| Assessing pleiotropy and mediation in genetic loci associated with chronic obstructive pulmonary disease. | Parker MM et al. | β | 2019 | β |
| Association of APOL1 renal disease risk alleles with Trypanosoma brucei rhodesiense infection outcomes in the northern part of Malawi. | Kamoto K et al. | β | 2019 | β |
| Bayesian Inference for Mixed Model-Based Genome-Wide Analysis of Expression Quantitative Trait Loci by Gibbs Sampling. | Lee C | β | 2019 | β |
| Biological and practical implications of genome-wide association study of schizophrenia using Bayesian variable selection. | Rowe B et al. | β | 2019 | β |
| BLINK: a package for the next level of genome-wide association studies with both individuals and markers in the millions. | Huang M et al. | β | 2019 | β |
| Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease. | Tesi N et al. | β | 2019 | β |
| Comparing the Utility of Mitochondrial and Nuclear DNA to Adjust for Genetic Ancestry in Association Studies. | Miller B et al. | β | 2019 | β |
| Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis. | Pai S et al. | β | 2019 | β |
| Distribution of local ancestry and evidence of adaptation in admixed populations. | Secolin R et al. | β | 2019 | β |
| Estimating variance components in population scale family trees. | Shor T et al. | β | 2019 | β |
| Evaluation of linkage disequilibrium, population structure, and genetic diversity in the U.S. peanut mini core collection. | Otyama PI et al. | β | 2019 | β |
| Exploring Listeria monocytogenes Transcriptomes in Correlation with Divergence of Lineages and Virulence as Measured in Galleria mellonella. | Lee BH et al. | β | 2019 | β |
| Fast and flexible linear mixed models for genome-wide genetics. | Runcie DE et al. | β | 2019 | β |
| Favorable alleles mining for gelatinization temperature, gel consistency and amylose content in Oryza sativa by association mapping. | Wang H et al. | β | 2019 | β |
| Functional genomic characterization of the <i>FTO</i> locus in African Americans. | Gill R et al. | β | 2019 | β |
| Genetic Architecture of Primary Open-Angle Glaucoma in Individuals of African Descent: The African Descent and Glaucoma Evaluation Study III. | Taylor KD et al. | β | 2019 | β |
| Genetic risk, body mass index, and weight control behaviors: Unlocking the triad. | Nagata JM et al. | β | 2019 | β |
| Genetics and the geography of health, behaviour and attainment. | Belsky DW et al. | β | 2019 | β |
| Genetics of cluster headache. | Gibson KF et al. | β | 2019 | β |
| Genetic Survey of Adult-Onset Idiopathic Intracranial Hypertension. | Kuehn MH et al. | β | 2019 | β |
| Genetic variation across the human olfactory receptor repertoire alters odor perception. | Trimmer C et al. | β | 2019 | β |
| Genome-wide associations and detection of potential candidate genes for direct genetic and maternal genetic effects influencing dairy cattle body weight at different ages. | Yin T et al. | β | 2019 | β |
| Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2. | Hernandez Cordero AI et al. | β | 2019 | β |
| Genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation. | Mebratie W et al. | β | 2019 | β |
| Genome-wide association study of milk and reproductive traits in dual-purpose Xinjiang Brown cattle. | Zhou J et al. | β | 2019 | β |
| Genome-wide sexually antagonistic variants reveal long-standing constraints on sexual dimorphism in fruit flies. | Ruzicka F et al. | β | 2019 | β |
| Genomic Regions Associated with IgE Levels against <i>Culicoides</i> spp. Antigens in Three Horse Breeds. | FranΓ§ois L et al. | β | 2019 | β |
| Honey bee predisposition of resistance to ubiquitous mite infestations. | Broeckx BJG et al. | β | 2019 | β |
| <i>De novo</i> Mutations From Whole Exome Sequencing in Neurodevelopmental and Psychiatric Disorders: From Discovery to Application. | Wang W et al. | β | 2019 | β |
| LEI: A Novel Allele Frequency-Based Feature Selection Method for Multi-ancestry Admixed Populations. | Wathen MJ et al. | β | 2019 | β |
| Mendelian Randomization and the Environmental Epigenetics of Health: a Systematic Review. | Grau-Perez M et al. | β | 2019 | β |
| "Mendelian Randomization" Approach in Economic Assessment of Health Conditions. | Gupta V et al. | β | 2019 | β |
| Modeling Heterogeneity in the Genetic Architecture of Ethnically Diverse Groups Using Random Effect Interaction Models. | Veturi Y et al. | β | 2019 | β |
| Odyssey: a semi-automated pipeline for phasing, imputation, and analysis of genome-wide genetic data. | Eller RJ et al. | β | 2019 | β |
| On Using Local Ancestry to Characterize the Genetic Architecture of Human Traits: Genetic Regulation of Gene Expression in Multiethnic or Admixed Populations. | Zhong Y et al. | β | 2019 | β |
| Phenotypic and genome-wide association with the local environment of Arabidopsis. | Ferrero-Serrano Γ et al. | β | 2019 | β |
| Polygenic liability for schizophrenia predicts shifting-specific executive function deficits and tobacco use in a moderate drinking community sample. | Miller AP et al. | β | 2019 | β |
| Principals about principal components in statistical genetics. | Abegaz F et al. | β | 2019 | β |
| QTG-Finder: A Machine-Learning Based Algorithm To Prioritize Causal Genes of Quantitative Trait Loci in Arabidopsis and Rice. | Lin F et al. | β | 2019 | β |
| SNPs associated with body weight and backfat thickness in two pig breeds identified by a genome-wide association study. | Yang Q et al. | β | 2019 | β |
| Statistical Association Mapping of Population-Structured Genetic Data. | Najafi A et al. | β | 2019 | β |
| The Future of Genomic Studies Must Be Globally Representative: Perspectives from PAGE. | Bien SA et al. | β | 2019 | β |
| Towards clinical utility of polygenic risk scores. | Lambert SA et al. | β | 2019 | β |
| Undesired fertility restoration in msm1 barley associates with two mTERF genes. | Bernhard T et al. | β | 2019 | β |
| Variants in ABCG8 and TRAF3 genes confer risk for gallstone disease in admixed Latinos with Mapuche Native American ancestry. | Bustos BI et al. | β | 2019 | β |
| Variations in maternal adenylate cyclase genes are associated with congenital Zika syndrome in a cohort from Northeast, Brazil. | Rossi ΓD et al. | β | 2019 | β |
| WhoGEM: an admixture-based prediction machine accurately predicts quantitative functional traits in plants. | Gentzbittel L et al. | β | 2019 | β |
| Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma. | Kachroo P et al. | β | 2019 | β |
| Accelerating genetic gains in legumes for the development of prosperous smallholder agriculture: integrating genomics, phenotyping, systems modelling and agronomy. | Varshney RK et al. | β | 2018 | β |
| Accurate and adaptive imputation of summary statistics in mixed-ethnicity cohorts. | Togninalli M et al. | β | 2018 | β |
| ADAPTIVE-WEIGHT BURDEN TEST FOR ASSOCIATIONS BETWEEN QUANTITATIVE TRAITS AND GENOTYPE DATA WITH COMPLEX CORRELATIONS. | Wu X et al. | β | 2018 | β |
| A deep hybrid model to detect multi-locus interacting SNPs in the presence of noise. | Uppu S et al. | β | 2018 | β |
| A Developmental Twin Study of Emotion Recognition and Its Negative Affective Clinical Correlates. | Rappaport LM et al. | β | 2018 | β |
| A global transcriptional network connecting noncoding mutations to changes in tumor gene expression. | Zhang W et al. | β | 2018 | β |
| A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis. | Kou I et al. | β | 2018 | β |
| Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague. | Spyrou MA et al. | β | 2018 | β |
| Analysis of causal effect of APOA5 variants on premature coronary artery disease. | Wang F et al. | β | 2018 | β |
| An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis. | Ogura Y et al. | β | 2018 | β |
| A practical approach to adjusting for population stratification in genome-wide association studies: principal components and propensity scores (PCAPS). | Zhao H et al. | β | 2018 | β |
| A tutorial on conducting genome-wide association studies: Quality control and statistical analysis. | Marees AT et al. | β | 2018 | β |
| Bias in Mendelian randomization due to assortative mating. | Hartwig FP et al. | β | 2018 | β |
| Breastfeeding moderates FTO related adiposity: a birth cohort study with 30 years of follow-up. | Horta BL et al. | β | 2018 | β |
| Charting the genotype-phenotype map: lessons from the Drosophila melanogaster Genetic Reference Panel. | Mackay TFC et al. | β | 2018 | β |
| Coherent synthesis of genomic associations with phenotypes and home environments. | Lasky JR et al. | β | 2018 | β |
| Comparative Aerial and Ground Based High Throughput Phenotyping for the Genetic Dissection of NDVI as a Proxy for Drought Adaptive Traits in Durum Wheat. | Condorelli GE et al. | β | 2018 | β |
| Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits. | Evans LM et al. | β | 2018 | β |
| Detection of Selection Signatures Among Brazilian, Sri Lankan, and Egyptian Chicken Populations Under Different Environmental Conditions. | Walugembe M et al. | β | 2018 | β |
| Discovering variation of secondary metabolite diversity and its relationship with disease resistance in <i>Cornus florida</i> L. | Pais AL et al. | β | 2018 | β |
| Expression profiling of disease progression in canine model of Duchenne muscular dystrophy. | Brinkmeyer-Langford C et al. | β | 2018 | β |
| Fast and powerful genome wide association of dense genetic data with high dimensional imaging phenotypes. | Ganjgahi H et al. | β | 2018 | β |
| Father Absence and Accelerated Reproductive Development in Non-Hispanic White Women in the United States. | Gaydosh L et al. | β | 2018 | β |
| Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP). | Ren H et al. | β | 2018 | β |
| Genetic analysis of social-class mobility in five longitudinal studies. | Belsky DW et al. | β | 2018 | β |
| Genetic Basis Underlying Correlations Among Growth Duration and Yield Traits Revealed by GWAS in Rice (<i>Oryza sativa</i> L.). | Li F et al. | β | 2018 | β |
| Genetic relatedness of indigenous ethnic groups in northern Borneo to neighboring populations from Southeast Asia, as inferred from genome-wide SNP data. | Yew CW et al. | β | 2018 | β |
| Genome-wide Analysis of Large-scale Longitudinal Outcomes using Penalization -GALLOP algorithm. | Sikorska K et al. | β | 2018 | β |
| Genome-Wide Association Studies and Comparison of Models and Cross-Validation Strategies for Genomic Prediction of Quality Traits in Advanced Winter Wheat Breeding Lines. | Kristensen PS et al. | β | 2018 | β |
| Genome-wide association study for reproductive traits in a Large White pig population. | Wang Y et al. | β | 2018 | β |
| Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry. | Sanchez-Roige S et al. | β | 2018 | β |
| Genome-wide association study to identify candidate loci and genes for Mn toxicity tolerance in rice. | Shrestha A et al. | β | 2018 | β |
| Genome-wide mapping of quantitative trait loci in admixed populations using mixed linear model and Bayesian multiple regression analysis. | Toosi A et al. | β | 2018 | β |
| Genome-wide pleiotropy and shared biological pathways for resistance to bovine pathogens. | Mahmoud M et al. | β | 2018 | β |
| Genomic prediction accuracy for switchgrass traits related to bioenergy within differentiated populations. | Fiedler JD et al. | β | 2018 | β |
| Heritability of body size in the polar bears of Western Hudson Bay. | Malenfant RM et al. | β | 2018 | β |
| Hidden Effects of Seed Quality Breeding on Germination in Oilseed Rape (<i>Brassica napus</i> L.). | Hatzig S et al. | β | 2018 | β |
| Inferring Population Structure and Admixture Proportions in Low-Depth NGS Data. | Meisner J et al. | β | 2018 | β |
| Influence of essential oils in diet and life-stage on gut microbiota and fillet quality of rainbow trout (Oncorhynchus mykiss). | Ceppa F et al. | β | 2018 | β |
| Key Concepts in Genetic Epidemiology. | Panoutsopoulou K et al. | β | 2018 | β |
| L-GATOR: Genetic Association Testing for a Longitudinally Measured Quantitative Trait in Samples with Related Individuals. | Wu X et al. | β | 2018 | β |
| Methodological implementation of mixed linear models in multi-locus genome-wide association studies. | Wen YJ et al. | β | 2018 | β |
| Narrow-sense heritability estimation of complex traits using identity-by-descent information. | Evans LM et al. | β | 2018 | β |
| Nonparametric approaches for population structure analysis. | Alhusain L et al. | β | 2018 | β |
| Of genes and microbes: solving the intricacies in host genomes. | Wang J et al. | β | 2018 | β |
| On Estimation of Genome Composition in Genetically Admixed Individuals Using Constrained Genomic Regression. | Boerner V et al. | β | 2018 | β |
| On the Road to Breeding 4.0: Unraveling the Good, the Bad, and the Boring of Crop Quantitative Genomics. | Wallace JG et al. | β | 2018 | β |
| Opportunities and obstacles for deep learning in biology and medicine. | Ching T et al. | β | 2018 | β |
| Optimising Genomic Selection in Wheat: Effect of Marker Density, Population Size and Population Structure on Prediction Accuracy. | Norman A et al. | β | 2018 | β |
| Patient similarity for precision medicine: A systematic review. | Parimbelli E et al. | β | 2018 | β |
| pKWmEB: integration of Kruskal-Wallis test with empirical Bayes under polygenic background control for multi-locus genome-wide association study. | Ren WL et al. | β | 2018 | β |
| Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer. | Gonzalez-Hormazabal P et al. | β | 2018 | β |
| Prioritizing diversity in human genomics research. | Hindorff LA et al. | β | 2018 | β |
| Profiling and Leveraging Relatedness in a Precision Medicine Cohort of 92,455 Exomes. | Staples J et al. | β | 2018 | β |
| Reducing cryptic relatedness in genomic data sets via a central node exclusion algorithm. | Fonseca PAS et al. | β | 2018 | β |
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| MYBPH acts as modifier of cardiac hypertrophy in hypertrophic cardiomyopathy (HCM) patients. | Mouton JM et al. | β | 2016 | β |
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| Genome-Wide Association Mapping for Resistance to Leaf and Stripe Rust in Winter-Habit Hexaploid Wheat Landraces. | Kertho A et al. | β | 2015 | β |
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| Genome-wide association study in an admixed case series reveals IL12A as a new candidate in BehΓ§et disease. | Kappen JH et al. | β | 2015 | β |
| Genome-wide association study of IgG1 responses to the choline-binding protein PspC of Streptococcus pneumoniae. | Anderson D et al. | β | 2015 | β |
| Genome-wide DArT and SNP scan for QTL associated with resistance to stripe rust (Puccinia striiformis f. sp. tritici) in elite ICARDA wheat (Triticum aestivum L.) germplasm. | Jighly A et al. | β | 2015 | β |
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| Genomic variation across landscapes: insights and applications. | Bragg JG et al. | β | 2015 | β |
| Greenlandic Inuit show genetic signatures of diet and climate adaptation. | Fumagalli M et al. | β | 2015 | β |
| Identification of Promising Mutants Associated with Egg Production Traits Revealed by Genome-Wide Association Study. | Yuan J et al. | β | 2015 | β |
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| Low but significant genetic differentiation underlies biologically meaningful phenotypic divergence in a large Atlantic salmon population. | Aykanat T et al. | β | 2015 | β |
| Mapping the genetic diversity of HLA haplotypes in the Japanese populations. | Saw WY et al. | β | 2015 | β |
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| The genetic basis of population fecundity prediction across multiple field populations of Nilaparvata lugens. | Sun ZX et al. | β | 2015 | β |
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| An excess of risk-increasing low-frequency variants can be a signal of polygenic inheritance in complex diseases. | Chan Y et al. | β | 2014 | β |
| A phylogeny-based sampling strategy and power calculator informs genome-wide associations study design for microbial pathogens. | Farhat MR et al. | β | 2014 | β |
| A population genetic signal of polygenic adaptation. | Berg JJ et al. | β | 2014 | β |
| A unified GMDR method for detecting gene-gene interactions in family and unrelated samples with application to nicotine dependence. | Chen GB et al. | β | 2014 | β |
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| Characterizing the genetic basis of bacterial phenotypes using genome-wide association studies: a new direction for bacteriology. | Read TD et al. | β | 2014 | β |
| Comparison of genome-wide association methods in analyses of admixed populations with complex familial relationships. | Kadri NK et al. | β | 2014 | β |
| Complex pedigrees in the sequencing era: to track transmissions or decorrelate? | Li D et al. | β | 2014 | β |
| Correlation analysis of genetic admixture and social identification with body mass index in a Native American community. | Norden-Krichmar TM et al. | β | 2014 | β |
| Deciphering the fine-structure of tribal admixture in the Bedouin population using genomic data. | Markus B et al. | β | 2014 | β |
| Detecting genetic interactions in pathway-based genome-wide association studies. | Huang A et al. | β | 2014 | β |
| Discovery and refinement of muscle weight QTLs in B6 Γ D2 advanced intercross mice. | Carbonetto P et al. | β | 2014 | β |
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| Epigenetic variation predicts regional and local intraspecific functional diversity in a perennial herb. | Medrano M et al. | β | 2014 | β |
| Epigenome-wide association studies without the need for cell-type composition. | Zou J et al. | β | 2014 | β |
| Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants. | Yang C et al. | β | 2014 | β |
| Female sexual dysfunction in patients with major depressive disorder (MDD) treated with selective serotonin reuptake inhibitor (SSRI) and its association with serotonin 2A-1438 G/A single nucleotide polymorphisms. | Masiran R et al. | β | 2014 | β |
| Fine mapping of type 2 diabetes susceptibility loci. | Morris AP | β | 2014 | β |
| Further improvements to linear mixed models for genome-wide association studies. | Widmer C et al. | β | 2014 | β |
| Gene-based association identifies SPATA13-AS1 as a pharmacogenomic predictor of inhaled short-acting beta-agonist response in multiple population groups. | Padhukasahasram B et al. | β | 2014 | β |
| Genetics of hypertension: discoveries from the bench to human populations. | Franceschini N et al. | β | 2014 | β |
| Genome-wide analysis of the heritability of amyotrophic lateral sclerosis. | Keller MF et al. | β | 2014 | β |
| Genome-wide association analysis of radiation resistance in Drosophila melanogaster. | Vaisnav M et al. | β | 2014 | β |
| Genome-wide association studies and prediction of 17 traits related to phenology, biomass and cell wall composition in the energy grass Miscanthus sinensis. | Slavov GT et al. | β | 2014 | β |
| Genome-wide association study identifies quantitative trait loci affecting hematological traits in an F2 intercross between Landrace and Korean native pigs. | Jung EJ et al. | β | 2014 | β |
| Genome-wide SNP analysis reveals a genetic basis for sea-age variation in a wild population of Atlantic salmon (Salmo salar). | Johnston SE et al. | β | 2014 | β |
| Hierarchical linear modeling of longitudinal pedigree data for genetic association analysis. | Tan Q et al. | β | 2014 | β |
| Identification of genetic loci associated with primary angle-closure glaucoma in the basset hound. | Ahram DF et al. | β | 2014 | β |
| Identification of genomic loci associated with Rhodococcus equi susceptibility in foals. | McQueen CM et al. | β | 2014 | β |
| Improving the power of GWAS and avoiding confounding from population stratification with PC-Select. | Tucker G et al. | β | 2014 | β |
| Individual variation in size and fecundity is correlated with differences in global DNA cytosine methylation in the perennial herb Helleborus foetidus (Ranunculaceae). | Alonso C et al. | β | 2014 | β |
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| Landscape genomics of Populus trichocarpa: the role of hybridization, limited gene flow, and natural selection in shaping patterns of population structure. | Geraldes A et al. | β | 2014 | β |
| lrgpr: interactive linear mixed model analysis of genome-wide association studies with composite hypothesis testing and regression diagnostics in R. | Hoffman GE et al. | β | 2014 | β |
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| Natural genetic variation impacts expression levels of coding, non-coding, and antisense transcripts in fission yeast. | ClΓ©ment-Ziza M et al. | β | 2014 | β |
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| Polymorphisms in MicroRNAs are associated with survival in non-small cell lung cancer. | Zhao Y et al. | β | 2014 | β |
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| Population genomics of Populus trichocarpa identifies signatures of selection and adaptive trait associations. | Evans LM et al. | β | 2014 | β |
| PREST-plus identifies pedigree errors and cryptic relatedness in the GAW18 sample using genome-wide SNP data. | Sun L et al. | β | 2014 | β |
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| Rare-variant association analysis: study designs and statistical tests. | Lee S et al. | β | 2014 | β |
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| TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population. | Cook-Sather SD et al. | β | 2014 | β |
| Testing genetic association with rare and common variants in family data. | Chen H et al. | β | 2014 | β |
| Testing the key assumption of heritability estimates based on genome-wide genetic relatedness. | Conley D et al. | β | 2014 | β |
| The application of network label propagation to rank biomarkers in genome-wide Alzheimer's data. | Stokes ME et al. | β | 2014 | β |
| The genetic inheritance of the blue-eyed white phenotype in alpacas (Vicugna pacos). | Jackling FC et al. | β | 2014 | β |
| The impact of population structure on genomic prediction in stratified populations. | Guo Z et al. | β | 2014 | β |
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