Semantic processing in alcoholics with and without antisocial symptomatology.
- Authors
- Ceballos, Natalie A; Nixon, Sara Jo; Phillips, Julia A; Tivis, Rick
- Year
- 2003
- Journal
- Journal of studies on alcohol
- PMID
- 12713204
- DOI
- 10.15288/jsa.2003.64.286
OBJECTIVE: Chronic alcoholics with a comorbid diagnosis of antisocial personality (ASP) symptomatology often exhibit early onset, severe course, and poor treatment outcomes. In addition, antisocial characteristics have been associated with a variety of cognitive deficits, including abnormalities of semantic processing, a deficit also found in alcoholics. Using the N400 task, this study investigated whether comorbid ASP symptomatology in alcoholics and community controls contributes to deficits in cognitive efficiency. METHOD: The N400 component of the event-related potential was elicited in detoxified alcoholics (n = 71; 56 male) and community controls (n = 36; 22 female) by sentences with congruent, related/incongruent or unrelated/incongruent terminal words. Difference waveforms were derived, and both amplitude and latency measures were obtained. Antisocial personality symptomatology was assessed using the ASP section of the Diagnostic Interview Schedule IV. RESULTS: Data were analyzed via linear regression using alcoholism, ASP positive (ASP+) status and their interaction term as predictors of N400 amplitude and latency. Significant latency findings were noted in the related/incongruent sentence condition. Increased N400 latency was predicted by ASP+ status at electrode site Pz (p = .01). The interaction of alcoholism and ASP+ status predicted increased N400 latency at electrode site P4 (p = .009), with ASP+ alcoholics demonstrating the greatest latency. CONCLUSIONS: The presence of N400 latency differences in response to related/incongruent semantic information in the current study differs from previous findings in studies of chronic alcoholism that do not account for ASP. These data suggest that antisocial personality disorder and alcoholism may affect cognitive function via different underlying mechanisms.
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|---|---|---|---|---|
| Predictors of chronicity in alcohol use disorder: an evoked response potential study. | Mishra P et al. | — | 2020 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | — | 2014 | → |
| Clinical and pathological features of alcohol-related brain damage. | Zahr NM et al. | — | 2011 | → |
| Reduced resource optimization in male alcoholics: N400 in a lexical decision paradigm. | Roopesh BN et al. | — | 2010 | → |
| The role of selected factors in the development and consequences of alcohol dependence. | Gilbertson R et al. | — | 2008 | → |
| Tobacco use, alcohol dependence, and cognitive performance. | Ceballos NA | — | 2006 | → |
| N400 as an index of semantic expectancies: differential effects of alcohol and cocaine dependence. | Ceballos NA et al. | — | 2005 | → |
| Neurocircuitry in alcoholism: a substrate of disruption and repair. | Sullivan EV et al. | — | 2005 | → |
| Visual-spatial attention in alcoholics and illicit stimulant abusers: effects of nicotine replacement. | Ceballos NA et al. | — | 2005 | → |