Glutamatergic substrates of drug addiction and alcoholism.
paper
Cited
Public
Unavailable
- Authors
- Gass, Justin T; Olive, M Foster
- Year
- 2008
- Journal
- Biochemical pharmacology
- PMID
- 17706608
- DOI
- 10.1016/j.bcp.2007.06.039
- PMCID
- PMC2239014
The past two decades have witnessed a dramatic accumulation of evidence indicating that the excitatory amino acid glutamate plays an important role in drug addiction and alcoholism. The purpose of this review is to summarize findings on glutamatergic substrates of addiction, surveying data from both human and animal studies. The effects of various drugs of abuse on glutamatergic neurotransmission are discussed, as are the effects of pharmacological or genetic manipulation of various components of glutamate transmission on drug reinforcement, conditioned reward, extinction, and relapse-like behavior. In addition, glutamatergic agents that are currently in use or are undergoing testing in clinical trials for the treatment of addiction are discussed, including acamprosate, N-acetylcysteine, modafinil, topiramate, lamotrigine, gabapentin and memantine. All drugs of abuse appear to modulate glutamatergic transmission, albeit by different mechanisms, and this modulation of glutamate transmission is believed to result in long-lasting neuroplastic changes in the brain that may contribute to the perseveration of drug-seeking behavior and drug-associated memories. In general, attenuation of glutamatergic transmission reduces drug reward, reinforcement, and relapse-like behavior. On the other hand, potentiation of glutamatergic transmission appears to facilitate the extinction of drug-seeking behavior. However, attempts at identifying genetic polymorphisms in components of glutamate transmission in humans have yielded only a limited number of candidate genes that may serve as risk factors for the development of addiction. Nonetheless, manipulation of glutamatergic neurotransmission appears to be a promising avenue of research in developing improved therapeutic agents for the treatment of drug addiction and alcoholism.
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| mGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal Cortex. | LaCrosse AL et al. | — | 2015 | → |
| N-acetylcysteine prevents behavioral and biochemical changes induced by alcohol cessation in rats. | Schneider R et al. | — | 2015 | → |
| Neurobiological Bases of Cue- and Nicotine-induced Reinstatement of Nicotine Seeking: Implications for the Development of Smoking Cessation Medications. | Stoker AK et al. | — | 2015 | → |
| Neurogenetics and gene therapy for reward deficiency syndrome: are we going to the Promised Land? | Blum K et al. | — | 2015 | → |
| N-methyl-D-aspartate receptor antagonism has differential effects on alcohol craving and drinking in heavy drinkers. | Krishnan-Sarin S et al. | — | 2015 | → |
| Postdependent state in rats as a model for medication development in alcoholism. | Meinhardt MW et al. | — | 2015 | → |
| Recent insights into the mode of action of memantine and ketamine. | Johnson JW et al. | — | 2015 | → |
| Region-specific effects of isoflurane anesthesia on Fos immunoreactivity in response to intravenous cocaine challenge in rats with a history of repeated cocaine administration. | Kufahl PR et al. | — | 2015 | → |
| Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport. | Griffin WC et al. | — | 2015 | → |
| Social interaction and cocaine conditioning in mice increase spontaneous spike frequency in the nucleus accumbens or septal nuclei as revealed by multielectrode array recordings. | Kummer KK et al. | — | 2015 | → |
| The uncompetitive N-methyl-D-aspartate antagonist memantine reduces binge-like eating, food-seeking behavior, and compulsive eating: role of the nucleus accumbens shell. | Smith KL et al. | — | 2015 | → |
| Achieving cannabis cessation -- evaluating N-acetylcysteine treatment (ACCENT): design and implementation of a multi-site, randomized controlled study in the National Institute on Drug Abuse Clinical Trials Network. | McClure EA et al. | — | 2014 | → |
| Alcohol dependence and free-choice drinking in mice. | Griffin WC | — | 2014 | → |
| Association of single-nucleotide polymorphisms in a metabotropic glutamate receptor GRM3 gene subunit to alcohol-dependent male subjects. | Xia Y et al. | — | 2014 | → |
| Binge alcohol drinking by mice requires intact group 1 metabotropic glutamate receptor signaling within the central nucleus of the amygdala. | Cozzoli DK et al. | — | 2014 | → |
| Bipolar disorder and gambling disorder comorbidity: current evidence and implications for pharmacological treatment. | Di Nicola M et al. | — | 2014 | → |
| Blocking TRPV1 in nucleus accumbens inhibits persistent morphine conditioned place preference expression in rats. | Heng LJ et al. | — | 2014 | → |
| Combination pharmacotherapies for stimulant use disorder: a review of clinical findings and recommendations for future research. | Stoops WW et al. | — | 2014 | → |
| Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models. | Jupp B et al. | — | 2014 | → |
| Effectiveness of Ceftriaxone Treatment in Preventing Relapse-like Drinking Behavior Following Long-term Ethanol Dependence in P Rats. | Rao P et al. | — | 2014 | → |
| GABA-A and NMDA receptor subunit mRNA expression is altered in the caudate but not the putamen of the postmortem brains of alcoholics. | Bhandage AK et al. | — | 2014 | → |
| Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent mice. | Griffin WC et al. | — | 2014 | → |
| Levetiracetam results in increased and decreased alcohol drinking with different access procedures in C57BL/6J mice. | Fish EW et al. | — | 2014 | → |
| Mechanisms of metabonomic for a gateway drug: nicotine priming enhances behavioral response to cocaine with modification in energy metabolism and neurotransmitter level. | Li H et al. | — | 2014 | → |
| Metabotropic glutamatergic receptors and their ligands in drug addiction. | Pomierny-Chamioło L et al. | — | 2014 | → |
| Modest long-term ethanol consumption affects expression of neurotransmitter receptor genes in the rat nucleus accumbens. | Jonsson S et al. | — | 2014 | → |
| Neurochemical mechanisms of alcohol withdrawal. | Becker HC et al. | — | 2014 | → |
| NrCAM-regulating neural systems and addiction-related behaviors. | Ishiguro H et al. | — | 2014 | → |
| [Pharmacological profiles and clinical roles of acamprosate (Regtect(®) tablets 333 mg) for the maintenance of abstinence in alcohol-dependent patients]. | Ohhara T et al. | — | 2014 | → |
| Pharmacologic treatment of alcoholism. | Anton RF et al. | — | 2014 | → |
| Potential role of N-acetylcysteine in the management of substance use disorders. | McClure EA et al. | — | 2014 | → |
| Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics. | Jin Z et al. | — | 2014 | → |
| Targeting the glutamatergic system to treat pathological gambling: current evidence and future perspectives. | Pettorruso M et al. | — | 2014 | → |
| The development of acamprosate as a treatment against alcohol relapse. | Kufahl PR et al. | — | 2014 | → |
| The effects of mGluR2/3 activation on acute and repeated amphetamine-induced locomotor activity in differentially reared male rats. | Arndt DL et al. | — | 2014 | → |
| Too difficult to stop: mechanisms facilitating relapse in alcohol dependence. | Garbusow M et al. | — | 2014 | → |
| Acetylcholine encodes long-lasting presynaptic plasticity at glutamatergic synapses in the dorsal striatum after repeated amphetamine exposure. | Wang W et al. | — | 2013 | → |
| Acute effects of modafinil on brain resting state networks in young healthy subjects. | Esposito R et al. | — | 2013 | → |
| Advances in genetic studies of substance abuse in China. | Sun Y et al. | — | 2013 | → |
| Alcohol drinking and deprivation alter basal extracellular glutamate concentrations and clearance in the mesolimbic system of alcohol-preferring (P) rats. | Ding ZM et al. | — | 2013 | → |
| Are AMPA receptor positive allosteric modulators potential pharmacotherapeutics for addiction? | Watterson LR et al. | — | 2013 | → |
| Attenuation of methamphetamine seeking by the mGluR2/3 agonist LY379268 in rats with histories of restricted and escalated self-administration. | Kufahl PR et al. | — | 2013 | → |
| Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator. | Watterson LR et al. | — | 2013 | → |
| Ceftriaxone, a beta-lactam antibiotic, attenuates relapse-like ethanol-drinking behavior in alcohol-preferring rats. | Qrunfleh AM et al. | — | 2013 | → |
| Craving in alcohol-dependent patients after detoxification is related to glutamatergic dysfunction in the nucleus accumbens and the anterior cingulate cortex. | Bauer J et al. | — | 2013 | → |
| Enhanced AMPA receptor activity increases operant alcohol self-administration and cue-induced reinstatement. | Cannady R et al. | — | 2013 | → |
| Ethanol-induced alterations of amino acids measured by in vivo microdialysis in rats: a meta-analysis. | Fliegel S et al. | — | 2013 | → |
| Glutamatergic targets for new alcohol medications. | Holmes A et al. | — | 2013 | → |
| Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain. | Harvey RJ et al. | — | 2013 | → |
| Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference. | Ary AW et al. | — | 2013 | → |
| Levetiracetam has opposite effects on alcohol- and cocaine-related behaviors in C57BL/6J mice. | Robinson JE et al. | — | 2013 | → |
| Metabotropic glutamate 7 (mGlu7) receptor: a target for medication development for the treatment of cocaine dependence. | Li X et al. | — | 2013 | → |
| mGluR1/5 receptor densities in the brains of alcoholic subjects: a whole-hemisphere autoradiography study. | Kupila J et al. | — | 2013 | → |
| mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats. | Sabino V et al. | — | 2013 | → |
| New Developments in Understanding and Treating Adolescent Marijuana Dependence. | Gray KM | — | 2013 | → |
| New insights on neurobiological mechanisms underlying alcohol addiction. | Cui C et al. | — | 2013 | → |
| NMDA Receptor Modulators in the Treatment of Drug Addiction. | Tomek SE et al. | — | 2013 | → |
| Pharmacotherapies for Overeating and Obesity. | Yarnell S et al. | — | 2013 | → |
| Positive or negative allosteric modulation of metabotropic glutamate receptor 5 (mGluR5) does not alter expression of behavioral sensitization to methamphetamine. | Kufahl PR et al. | — | 2013 | → |
| Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site. | Debrouse L et al. | — | 2013 | → |
| Role of mGluR5 neurotransmission in reinstated cocaine-seeking. | Wang X et al. | — | 2013 | → |
| Safety and efficacy of acamprosate for the treatment of alcohol dependence. | Yahn SL et al. | — | 2013 | → |
| S-(N, N-diethylcarbamoyl)glutathione (carbamathione), a disulfiram metabolite and its effect on nucleus accumbens and prefrontal cortex dopamine, GABA, and glutamate: a microdialysis study. | Faiman MD et al. | — | 2013 | → |
| The influence of ionotropic and metabotropic glutamate receptor ligands on anxiety-like effect of amphetamine withdrawal in rats. | Koltunowska D et al. | — | 2013 | → |
| The neurobiology of alcohol consumption and alcoholism: an integrative history. | Tabakoff B et al. | — | 2013 | → |
| Alcoholism and cellular vulnerability in different brain regions. | Skuja S et al. | — | 2012 | → |
| Alteration of glutamate/GABA balance during acute alcohol withdrawal in emergency department: a prospective analysis. | Brousse G et al. | — | 2012 | → |
| Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity. | Bell RL et al. | — | 2012 | → |
| An in vitro model for studying the effects of continuous ethanol exposure on N-methyl-D-aspartate receptor function. | Nath V et al. | — | 2012 | → |
| A randomized, double-blind, placebo-controlled, trial of lamotrigine therapy in bipolar disorder, depressed or mixed phase and cocaine dependence. | Brown ES et al. | — | 2012 | → |
| Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. | Fernàndez-Castillo N et al. | — | 2012 | → |
| Cocaine-taking and cocaine-seeking behaviors in rats remain stable after systemic administration of GYKI 52466: a non-competitive AMPA receptor antagonist. | Srivastava R et al. | — | 2012 | → |
| Could piracetam potentiate behavioural effects of psychostimulants? | Slais K et al. | — | 2012 | → |
| Dissociable role of tumor necrosis factor alpha gene deletion in methamphetamine self-administration and cue-induced relapsing behavior in mice. | Yan Y et al. | — | 2012 | → |
| Effects of alcohol on the membrane excitability and synaptic transmission of medium spiny neurons in the nucleus accumbens. | Marty VN et al. | — | 2012 | → |
| Ethanol up-regulates nucleus accumbens neuronal activity dependent pentraxin (Narp): implications for alcohol-induced behavioral plasticity. | Ary AW et al. | — | 2012 | → |
| Extinction-dependent alterations in corticostriatal mGluR2/3 and mGluR7 receptors following chronic methamphetamine self-administration in rats. | Schwendt M et al. | — | 2012 | → |
| Gene coexpression networks in human brain identify epigenetic modifications in alcohol dependence. | Ponomarev I et al. | — | 2012 | → |
| Genetic and environmental determinants of stress responding. | Clarke TK et al. | — | 2012 | → |
| Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications. | Wolen AR et al. | — | 2012 | → |
| Glutamate, GABA, and other cortical metabolite concentrations during early abstinence from alcohol and their associations with neurocognitive changes. | Mon A et al. | — | 2012 | → |
| Glutamatergic medications for the treatment of drug and behavioral addictions. | Olive MF et al. | — | 2012 | → |
| Glutamate transporter 1: target for the treatment of alcohol dependence. | Rao PS et al. | — | 2012 | → |
| Introduction to the special issue "Pharmacotherapies for the treatment of alcohol abuse and dependence" and a summary of patents targeting other neurotransmitter systems. | Bell RL et al. | — | 2012 | → |
| mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior. | Sinclair CM et al. | — | 2012 | → |
| mGluR-Dependent Synaptic Plasticity in Drug-Seeking. | Bellone C et al. | — | 2012 | → |
| mGlu receptors and drug addiction. | Cleva RM et al. | — | 2012 | → |
| MR spectroscopy in opiate maintenance therapy: association of glutamate with the number of previous withdrawals in the anterior cingulate cortex. | Hermann D et al. | — | 2012 | → |
| Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures. | Cozzoli DK et al. | — | 2012 | → |
| Positive Allosteric Modulation of mGluR5 Accelerates Extinction Learning but Not Relearning Following Methamphetamine Self-Administration. | Kufahl PR et al. | — | 2012 | → |
| Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 days of morphine withdrawal. | Wu X et al. | — | 2012 | → |
| The role of memantine in the treatment of psychiatric disorders other than the dementias: a review of current preclinical and clinical evidence. | Sani G et al. | — | 2012 | → |
| Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats. | Hermann D et al. | — | 2012 | → |
| Acamprosate in the treatment of binge eating disorder: a placebo-controlled trial. | McElroy SL et al. | — | 2011 | → |
| Accumbens Homer2-mediated signaling: a factor contributing to mouse strain differences in alcohol drinking? | Goulding SP et al. | — | 2011 | → |
| Alcohol-seeking behavior is associated with increased glutamate transmission in basolateral amygdala and nucleus accumbens as measured by glutamate-oxidase-coated biosensors. | Gass JT et al. | — | 2011 | → |
| Alternative splicing of AMPA subunits in prefrontal cortical fields of cynomolgus monkeys following chronic ethanol self-administration. | Acosta G et al. | — | 2011 | → |
| A novel role for PSD-95 in mediating ethanol intoxication, drinking and place preference. | Camp MC et al. | — | 2011 | → |
| A placebo controlled trial of memantine as an adjunct to oral naltrexone for opioid dependence. | Bisaga A et al. | — | 2011 | → |
| A role for accumbal glycine receptors in modulation of dopamine release by the glycine transporter-1 inhibitor org25935. | Lidö HH et al. | — | 2011 | → |
| Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinking. | Tanchuck MA et al. | — | 2011 | → |
| Brain region-selective cellular redistribution of mGlu5 but not GABA(B) receptors following methamphetamine-induced associative learning. | Herrold AA et al. | — | 2011 | → |
| Circadian and acamprosate modulation of elevated ethanol drinking in mPer2 clock gene mutant mice. | Brager AJ et al. | — | 2011 | → |
| Cognitive enhancers in the treatment of substance use disorders: clinical evidence. | Brady KT et al. | — | 2011 | → |
| Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats. | Dhanya RP et al. | — | 2011 | → |
| Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine. | Veeneman MM et al. | — | 2011 | → |
| Gabapentin combined with naltrexone for the treatment of alcohol dependence. | Anton RF et al. | — | 2011 | → |
| Getting a Knack for NAC: N-Acetyl-Cysteine. | Sansone RA et al. | — | 2011 | → |
| Glutamate transporter subtype 1 (GLT-1) activator ceftriaxone attenuates amphetamine-induced hyperactivity and behavioral sensitization in rats. | Rasmussen B et al. | — | 2011 | → |
| Investigating Methamphetamine Craving Using the Extinction-Reinstatement Model in the Rat. | Kufahl PR et al. | — | 2011 | → |
| Lesions of nucleus accumbens affect morphine-induced release of ascorbic acid and GABA but not of glutamate in rats. | Sun JY et al. | — | 2011 | → |
| Massive acetylcysteine overdose associated with cerebral edema and seizures. | Heard K et al. | — | 2011 | → |
| Memantine abolishes the formation of cocaine-induced conditioned place preference possibly via its IL-6-modulating effect in medial prefrontal cortex. | Lin KY et al. | — | 2011 | → |
| Memantine reduces consumption of highly palatable food in a rat model of binge eating. | Popik P et al. | — | 2011 | → |
| Merger fever: can two separate mechanisms work together to explain why we drink? | Holmes A | — | 2011 | → |
| New medications for drug addiction hiding in glutamatergic neuroplasticity. | Kalivas PW et al. | — | 2011 | → |
| Perturbation of the glutamate-glutamine system in alcohol dependence and remission. | Thoma R et al. | — | 2011 | → |
| Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review. | Frye CA et al. | — | 2011 | → |
| Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse. | Moussawi K et al. | — | 2011 | → |
| Role of the serotonergic system in alcohol dependence: from animal models to clinics. | Sari Y et al. | — | 2011 | → |
| Stimulant abuse: pharmacology, cocaine, methamphetamine, treatment, attempts at pharmacotherapy. | Ciccarone D | — | 2011 | → |
| The role of group I mGlu receptors in the expression of ethanol-induced conditioned place preference and ethanol withdrawal seizures in rats. | Kotlinska JH et al. | — | 2011 | → |
| Treatment of alcohol dependence with low-dose topiramate: an open-label controlled study. | Paparrigopoulos T et al. | — | 2011 | → |
| Understanding and treating opioid addiction in a patient with cancer pain. | Kircher S et al. | — | 2011 | → |
| Acetyl-L-carnitine for alcohol craving and relapse prevention in anhedonic alcoholics: a randomized, double-blind, placebo-controlled pilot trial. | Martinotti G et al. | — | 2010 | → |
| An open pilot study of tiagabine in alcohol dependence: tolerability and clinical effects. | Paparrigopoulos T et al. | — | 2010 | → |
| A placebo-controlled trial of memantine for cocaine dependence with high-value voucher incentives during a pre-randomization lead-in period. | Bisaga A et al. | — | 2010 | → |
| Brain stimulation in the study and treatment of addiction. | Feil J et al. | — | 2010 | → |
| Cocaine causes memory and learning impairments in rats: involvement of nuclear factor kappa B and oxidative stress, and prevention by topiramate. | Muriach M et al. | — | 2010 | → |
| Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction. | Schmidt HD et al. | — | 2010 | → |
| Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction. | Olive MF | — | 2010 | → |
| Constant activity of glutamine synthetase after morphine administration versus proteomic results. | Bodzon-Kulakowska A et al. | — | 2010 | → |
| D-cycloserine inhibits the development and the expression of locomotor sensitization to amphetamine in rats. | Gaiardi M et al. | — | 2010 | → |
| Deletion of the GluR5 subunit of kainate receptors affects cocaine sensitivity and preference. | Gregus AM et al. | — | 2010 | → |
| Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats. | Xie X et al. | — | 2010 | → |
| Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence. | Sidhpura N et al. | — | 2010 | → |
| Ethanol self-administration modulation of NMDA receptor subunit and related synaptic protein mRNA expression in prefrontal cortical fields in cynomolgus monkeys. | Acosta G et al. | — | 2010 | → |
| Expression of NMDA receptor subunits in human peripheral blood lymphocytes in opioid addiction. | Roozafzoon R et al. | — | 2010 | → |
| Glial dysfunction in abstinent methamphetamine abusers. | Sailasuta N et al. | — | 2010 | → |
| Glycine receptors involved in acamprosate's modulation of accumbal dopamine levels: an in vivo microdialysis study. | Chau P et al. | — | 2010 | → |
| Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats. | Vengeliene V et al. | — | 2010 | → |
| Individualised treatment in alcohol-dependent patients. | Mann K et al. | — | 2010 | → |
| Involvement of the brain histaminergic system in addiction and addiction-related behaviors: a comprehensive review with emphasis on the potential therapeutic use of histaminergic compounds in drug dependence. | Brabant C et al. | — | 2010 | → |
| Modafinil blocks reinstatement of extinguished opiate-seeking in rats: mediation by a glutamate mechanism. | Tahsili-Fahadan P et al. | — | 2010 | → |
| N-acetylcysteine (NAC) in young marijuana users: an open-label pilot study. | Gray KM et al. | — | 2010 | → |
| Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction. | Licata SC et al. | — | 2010 | → |
| Pharmacogenetics of alcohol and alcohol dependence treatment. | Kranzler HR et al. | — | 2010 | → |
| Phosphorylation regulates removal of synaptic N-methyl-D-aspartate receptors after withdrawal from chronic ethanol exposure. | Clapp P et al. | — | 2010 | → |
| Reduced effect of NMDA glutamate receptor antagonist on ethanol-induced ataxia and striatal glutamate levels in mice lacking ENT1. | Nam HW et al. | — | 2010 | → |
| The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats. | Jin X et al. | — | 2010 | → |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | — | 2009 | → |
| Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence. | Kranzler HR et al. | — | 2009 | → |
| Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. | Cozzoli DK et al. | — | 2009 | → |
| Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats. | Obara I et al. | — | 2009 | → |
| Effects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress. | Chen YC et al. | — | 2009 | → |
| Ethanol enhances glutamate transmission by retrograde dopamine signaling in a postsynaptic neuron/synaptic bouton preparation from the ventral tegmental area. | Deng C et al. | — | 2009 | → |
| Glutamate and reinstatement. | Knackstedt LA et al. | — | 2009 | → |
| Glutamate Neurotransmission in Psychotic Disorders and Substance Abuse. | Kerner B | — | 2009 | → |
| Interference of ethanol and methylmercury in the developing central nervous system. | Maia CS et al. | — | 2009 | → |
| Lamotrigine in the treatment of binge-eating disorder with obesity: a randomized, placebo-controlled monotherapy trial. | Guerdjikova AI et al. | — | 2009 | → |
| Mechanism-based medication development for the treatment of nicotine dependence. | Xi ZX et al. | — | 2009 | → |
| mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse. | Gaval-Cruz M et al. | — | 2009 | → |
| Metabotropic glutamate receptor ligands as potential therapeutics for addiction. | Olive MF | — | 2009 | → |
| mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats. | Gass JT et al. | — | 2009 | → |
| Modulation of brain endocannabinoid levels by voluntary alcohol consumption in alcohol-preferring AA rats. | Malinen H et al. | — | 2009 | → |
| Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell. | Gass JT et al. | — | 2009 | → |
| The effects of lamotrigine on the acquisition and expression of morphine-induced place preference in mice. | Tehrani SP et al. | — | 2009 | → |
| The encoding of cocaine vs. natural rewards in the striatum of nonhuman primates: categories with different activations. | Opris I et al. | — | 2009 | → |
| The role of cystine-glutamate exchange in nicotine dependence in rats and humans. | Knackstedt LA et al. | — | 2009 | → |
| The role of glutamate and its receptors in mesocorticolimbic dopaminergic regions in opioid addiction. | Guo Y et al. | — | 2009 | → |
| Young Investigator Award symposium. | Witkiewitz K et al. | — | 2009 | → |
| Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine. | Webb KJ et al. | — | 2009 | → |
| A role for mGluR5 receptors in intravenous methamphetamine self-administration. | Osborne MP et al. | — | 2008 | → |
| Decrease in tobacco consumption after treatment with topiramate and aripiprazole: a case report. | Arbaizar B et al. | — | 2008 | → |
| Drugs for relapse prevention of alcoholism: ten years of progress. | Spanagel R et al. | — | 2008 | → |
| Effects of the mGluR2/3 agonist LY379268 and the mGluR5 antagonist MPEP on handling-induced convulsions during ethanol withdrawal in mice. | Olive MF et al. | — | 2008 | → |
| Hypothesis-driven medication discovery for the treatment of psychostimulant addiction. | Xi ZX et al. | — | 2008 | → |
| Neuropharmacology of alcohol addiction. | Vengeliene V et al. | — | 2008 | → |
| Relationship between ethanol's acute locomotor effects and ethanol self-administration in male Long-Evans rats. | Chappell AM et al. | — | 2008 | → |
| Review. Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disorders. | Wong CC et al. | — | 2008 | → |
| Role of the glutamatergic system in nicotine dependence : implications for the discovery and development of new pharmacological smoking cessation therapies. | Liechti ME et al. | — | 2008 | → |
| Silicon Wafer-Based Platinum Microelectrode Array Biosensor for Near Real-Time Measurement of Glutamate in Vivo. | Wassum KM et al. | — | 2008 | → |
| The effect of 12-week open-label memantine treatment on cognitive function improvement in patients with alcohol-related dementia. | Cheon Y et al. | — | 2008 | → |
| Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEP. | Gass JT et al. | — | 2008 | → |
| Treatment implications: using neuroscience to guide the development of new pharmacotherapies for alcoholism. | Krishnan-Sarin S et al. | — | 2008 | → |