Genetic epidemiology of COPD (COPDGene) study design.
paper
Cited
Public
- Authors
- Regan, Elizabeth A; Hokanson, John E; Murphy, James R; Make, Barry; Lynch, David A; Beaty, Terri H; Curran-Everett, Douglas; Silverman, Edwin K; Crapo, James D
- Year
- 2010
- Journal
- COPD
- PMID
- 20214461
- DOI
- 10.3109/15412550903499522
- PMCID
- PMC2924193
BACKGROUND: COPDGene is a multicenter observational study designed to identify genetic factors associated with COPD. It will also characterize chest CT phenotypes in COPD subjects, including assessment of emphysema, gas trapping, and airway wall thickening. Finally, subtypes of COPD based on these phenotypes will be used in a comprehensive genome-wide study to identify COPD susceptibility genes. METHODS/RESULTS: COPDGene will enroll 10,000 smokers with and without COPD across the GOLD stages. Both Non-Hispanic white and African-American subjects are included in the cohort. Inspiratory and expiratory chest CT scans will be obtained on all participants. In addition to the cross-sectional enrollment process, these subjects will be followed regularly for longitudinal studies. A genome-wide association study (GWAS) will be done on an initial group of 4000 subjects to identify genetic variants associated with case-control status and several quantitative phenotypes related to COPD. The initial findings will be verified in an additional 2000 COPD cases and 2000 smoking control subjects, and further validation association studies will be carried out. CONCLUSIONS: COPDGene will provide important new information about genetic factors in COPD, and will characterize the disease process using high resolution CT scans. Understanding genetic factors and CT phenotypes that define COPD will potentially permit earlier diagnosis of this disease and may lead to the development of treatments to modify progression.
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| Utility of peripheral protein biomarkers for the prediction of incident interstitial features: a multicentre retrospective cohort study. | Ash S et al. | โ | 2024 | โ |
| Validation of Systemic Complement Signatures in the Progression of Chronic Obstructive Pulmonary Disease. | DiLillo KM et al. | โ | 2024 | โ |
| Airway-Occluding Mucus Plugs and Mortality in Patients With Chronic Obstructive Pulmonary Disease. | Diaz AA et al. | โ | 2023 | โ |
| Alpha-1 antitrypsin inhibits fractalkine-mediated monocyte-lung endothelial cell interactions. | Mikosz A et al. | โ | 2023 | โ |
| A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities. | Moll M et al. | โ | 2023 | โ |
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| Associations Between Muscle Weakness and Clinical Outcomes in Current and Former Smokers. | Zou RH et al. | โ | 2023 | โ |
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| Bilirubin-associated single nucleotide polymorphism (SNP) and respiratory health outcomes: a mendelian randomization study. | Baldomero AK et al. | โ | 2023 | โ |
| Blood Gene Expression and Immune Cell Subtypes Associated with Chronic Obstructive Pulmonary Disease Exacerbations. | Ryu MH et al. | โ | 2023 | โ |
| Cascading Affine and B-spline Registration Method for Large Deformation Registration of Lung X-rays. | Chang Q et al. | โ | 2023 | โ |
| Causes of and Clinical Features Associated with Death in Tobacco Cigarette Users by Lung Function Impairment. | Labaki WW et al. | โ | 2023 | โ |
| Chest MRI and CT Predictors of 10-Year All-Cause Mortality in COPD. | Sharma M et al. | โ | 2023 | โ |
| Cigarette smoking and disproportionate changes of thoracic skeletal muscles in low-dose chest computed tomography. | Lim WH et al. | โ | 2023 | โ |
| Clinical Markers Associated With Risk of Suicide or Drug Overdose Among Individuals Withย Smoking Exposure: A Longitudinal Follow-up Study of the COPDGene Cohort. | Adviento BA et al. | โ | 2023 | โ |
| Continuum finite element analysis generalizes<i>in vivo</i>trabecular bone microstructural strength measures between two CT scanners with different image resolution. | Guha I et al. | โ | 2023 | โ |
| Deep Learning Assessment of Progression of Emphysema and Fibrotic Interstitial Lung Abnormality. | Ash SY et al. | โ | 2023 | โ |
| Deep Learning Integration of Chest Computed Tomography Imaging and Gene Expression Identifies Novel Aspects of COPD. | Chen J et al. | โ | 2023 | โ |
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| Diffusing Capacity and Mortality in Chronic Obstructive Pulmonary Disease. | Balasubramanian A et al. | โ | 2023 | โ |
| Direct estimation of regional lung volume change from paired and single CT images using residual regression neural network. | Gerard SE et al. | โ | 2023 | โ |
| Discriminative Accuracy of the CAPTURE Tool for Identifying Chronic Obstructive Pulmonary Disease in US Primary Care Settings. | Martinez FJ et al. | โ | 2023 | โ |
| Electronic cigarette menthol flavoring is associated with increased inhaled micro and sub-micron particles and worse lung function in combustion cigarette smokers. | Chandra D et al. | โ | 2023 | โ |
| Emphysema subtyping on thoracic computed tomography scans using deep neural networks. | Xie W et al. | โ | 2023 | โ |
| Evaluation of graphical models for multi-group metabolomics data. | Zhao H et al. | โ | 2023 | โ |
| FEV<sub>1</sub>/FVC Severity Stages for Chronic Obstructive Pulmonary Disease. | Bhatt SP et al. | โ | 2023 | โ |
| Findings on High Resolution Computed Tomography in Symptomatic Veterans with Deployment-Related Lung Disease. | Rose CS et al. | โ | 2023 | โ |
| Flow-Volume Curve Patterns in Radiologic Expiratory Central Airway Collapse. | Kalehoff JP et al. | โ | 2023 | โ |
| From pre-COPD to COPD: a Simple, Low cost and easy to IMplement (SLIM) risk calculator. | Divo MJ et al. | โ | 2023 | โ |
| Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes. | Van Buren E et al. | โ | 2023 | โ |
| Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease. | Chen Y et al. | โ | 2023 | โ |
| GradICON: Approximate Diffeomorphisms via Gradient Inverse Consistency. | Tian L et al. | โ | 2023 | โ |
| Hepatitis C and HIV detection by blood RNA-sequencing in cohort of smokers. | Morrow JD et al. | โ | 2023 | โ |
| Heterogeneity and Progression of Chronic Obstructive Pulmonary Disease: Emphysema-Predominant and Non-Emphysema-Predominant Disease. | Castaldi PJ et al. | โ | 2023 | โ |
| Hierarchical association of COPD to principal genetic components of biological systems. | Carlin DE et al. | โ | 2023 | โ |
| Idiopathic pulmonary fibrosis is more strongly associated with coronary artery disease than chronic obstructive pulmonary disease. | Bray K et al. | โ | 2023 | โ |
| Impact of Interstitial Lung Abnormalities on Disease Expression and Outcomes in COPD or Emphysema: A Systematic Review. | Liu Y et al. | โ | 2023 | โ |
| Influence of Pulsatility and Inflow Waveforms on Tracheal Airflow Dynamics in Healthy Older Adults. | Tiwari B et al. | โ | 2023 | โ |
| Large scale proteomic studies create novel privacy considerations. | Hill AC et al. | โ | 2023 | โ |
| LEF1 isoforms regulate cellular senescence and aging. | Jia M et al. | โ | 2023 | โ |
| Longitudinal Assessment of Multimorbidity Medication Patterns among Smokers in the COPDGene Cohort. | Li Y et al. | โ | 2023 | โ |
| Lung volumes differentiate the predominance of emphysema <i>versus</i> airway disease phenotype in early COPD: an observational study of the COPDGene cohort. | Zeng S et al. | โ | 2023 | โ |
| Machine learning and deep learning predictive models for long-term prognosis in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. | Smith LA et al. | โ | 2023 | โ |
| Machine learning for screening of at-risk, mild and moderate COPD patients at risk of FEV<sub>1</sub> decline: results from COPDGene and SPIROMICS. | Wang JM et al. | โ | 2023 | โ |
| Metabolomics in COPD. | Gea J et al. | โ | 2023 | โ |
| Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing. | Jakubek YA et al. | โ | 2023 | โ |
| Multi-site, Multi-domain Airway Tree Modeling. | Zhang M et al. | โ | 2023 | โ |
| Networks as Biomarkers: Uses and Purposes. | Alfano C et al. | โ | 2023 | โ |
| Optimal Threshold of FEV<sub>t</sub>/FVC Ratio for Detection of Airflow Limitation Associated with Structural Lung Disease. | Bhatt SP et al. | โ | 2023 | โ |
| Parameter D: New Measure of Airflow Obstruction. | Bhatt SP et al. | โ | 2023 | โ |
| Plasma metabolomics and quantitative interstitial abnormalities in ever-smokers. | Choi B et al. | โ | 2023 | โ |
| Polygenic risk scores identify heterogeneity in asthma and chronic obstructive pulmonary disease. | Moll M et al. | โ | 2023 | โ |
| Predicting severe chronic obstructive pulmonary disease exacerbations using quantitative CT: a retrospective model development and external validation study. | Chaudhary MFA et al. | โ | 2023 | โ |
| Prevalence and mortality associations of interstitial lung abnormalities in rheumatoid arthritis within a multicentre prospective cohort of smokers. | McDermott GC et al. | โ | 2023 | โ |
| Prevalence of abnormal spirometry in individuals with a smoking history and no known obstructive lung disease. | Tran TV et al. | โ | 2023 | โ |
| Principal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD. | Verstraete K et al. | โ | 2023 | โ |
| Pulmonary emphysema subtypes defined by unsupervised machine learning on CT scans. | Angelini ED et al. | โ | 2023 | โ |
| Quantifying the spatial clustering characteristics of radiographic emphysema explains variability in pulmonary function. | Vestal BE et al. | โ | 2023 | โ |
| QUANTITATIVE BIOMARKERS REPRODUCIBILITY USING GENERATIVE ADVERSARIAL APPROACHES IN REDUCED TO CONVENTIONAL DOSE CT. | Nardelli P et al. | โ | 2023 | โ |
| Quantitative CT Analysis Based on Smoking Habits and Chronic Obstructive Pulmonary Disease in Patients with Normal Chest CT. | Byon JH et al. | โ | 2023 | โ |
| Quantitative CT Evaluation of Emphysema Progression over 10 Years in the COPDGene Study. | Baraghoshi D et al. | โ | 2023 | โ |
| Quantitative Interstitial Abnormality Progression and Outcomes in the Genetic Epidemiology of COPD and Pittsburgh Lung Screening Study Cohorts. | Choi B et al. | โ | 2023 | โ |
| Race-Specific Spirometry Equations Do Not Improve Models of Dyspnea and Quantitative Chest CT Phenotypes. | Non AL et al. | โ | 2023 | โ |
| Radiomics for Improved Detection of Chronic Obstructive Pulmonary Disease in Low-Dose and Standard-Dose Chest CT Scans. | Amudala Puchakayala PR et al. | โ | 2023 | โ |
| Repeatability of Pulmonary Quantitative Computed Tomography Measurements in Chronic Obstructive Pulmonary Disease. | Motahari A et al. | โ | 2023 | โ |
| Residual Volume versus FRC Computed Tomography Assessment of Functional Small Airway Disease in Smokers with and without Chronic Obstructive Pulmonary Disease. | Comellas AP et al. | โ | 2023 | โ |
| Returning incidentally discovered Hepatitis C RNA-seq results to COPDGene study participants. | Silverman EK et al. | โ | 2023 | โ |
| Risk Stratifying Interstitial Lung Abnormalities to Guide Early Diagnosis of Interstitial Lung Diseases. | Wijsenbeek MS et al. | โ | 2023 | โ |
| Single Modality vs. Multimodality: What Works Best for Lung Cancer Screening? | Sousa JV et al. | โ | 2023 | โ |
| Suspected Bronchiectasis and Mortality in Adults With a History of Smoking Who Have Normal and Impaired Lung Function : A Cohort Study. | Diaz AA et al. | โ | 2023 | โ |
| Suspected Interstitial Lung Disease in COPDGene Study. | Rose JA et al. | โ | 2023 | โ |
| The Promise of Quantitative Computed Tomographic Analysis in Assessing Progression of Interstitial Lung Abnormalities and Emphysema in Smokers. | Larici AR et al. | โ | 2023 | โ |
| The utility of quantitative computed tomography in cohort studies of chronic obstructive pulmonary disease: a narrative review. | Dai Q et al. | โ | 2023 | โ |
| TreeKernel: interpretable kernel machine tests for interactions between -omics and clinical predictors with applications to metabolomics and COPD phenotypes. | Carpenter CM et al. | โ | 2023 | โ |
| Understanding COPD Etiology, Pathophysiology, and Definition. | Curtis JL | โ | 2023 | โ |
| Unsupervised representation learning improves genomic discovery and risk prediction for respiratory and circulatory functions and diseases | Yun T et al. | โ | 2023 | โ |
| Update on metabolomic findings in COPD patients. | Gea J et al. | โ | 2023 | โ |
| Use of the Spirometric "Fixed-Ratio" Underdiagnoses COPD in African-Americans in a Longitudinal Cohort Study. | Regan EA et al. | โ | 2023 | โ |
| X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study. | Hayden LP et al. | โ | 2023 | โ |
| 10-Year Follow-Up of Lung Function, Respiratory Symptoms, and Functional Capacity in the COPDGene Study. | Ragland MF et al. | โ | 2022 | โ |
| A computationally efficient clustering linear combination approach to jointly analyze multiple phenotypes for GWAS. | Wang M et al. | โ | 2022 | โ |
| Acute Exacerbations Are Associated with Progression of Emphysema. | Bhatt SP et al. | โ | 2022 | โ |
| A genome-wide association study of bronchodilator response in participants of European and African ancestry from six independent cohorts. | Gereige JD et al. | โ | 2022 | โ |
| Airway Detection in COPD at Low-Dose CT Using Deep Learning and Multiparametric Freeze and Grow. | Nadeem SA et al. | โ | 2022 | โ |
| Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease. | Ghosh AJ et al. | โ | 2022 | โ |
| A Metabolomic Severity Score for Airflow Obstruction and Emphysema. | Godbole S et al. | โ | 2022 | โ |
| An interferon-inducible signature of airway disease from blood gene expression profiling. | Yun JH et al. | โ | 2022 | โ |
| A polygenic risk score and age of diagnosis of COPD. | Zhang J et al. | โ | 2022 | โ |
| A review of deep learning-based deformable medical image registration. | Zou J et al. | โ | 2022 | โ |
| Artificial Intelligence for Interstitial Lung Disease Analysis on Chest Computed Tomography: A Systematic Review. | Soffer S et al. | โ | 2022 | โ |
| A Smoothed Version of the Lassosum Penalty for Fitting Integrated Risk Models Using Summary Statistics or Individual-Level Data. | Hahn G et al. | โ | 2022 | โ |
| Association of body mass index and COPD exacerbation among patients with chronic bronchitis. | Shin SH et al. | โ | 2022 | โ |
| Association of clonal hematopoiesis with chronic obstructive pulmonary disease. | Miller PG et al. | โ | 2022 | โ |
| Association of tobacco product use with chronic obstructive pulmonary disease (COPD) prevalence and incidence in Waves 1 through 5 (2013-2019) of the Population Assessment of Tobacco and Health (PATH) Study. | Paulin LM et al. | โ | 2022 | โ |
| Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung Abnormalities. | Kim JS et al. | โ | 2022 | โ |
| A statistical physics approach for disease module detection. | Wang XW et al. | โ | 2022 | โ |
| Automated estimation of total lung volume using chest radiographs and deep learning. | Sogancioglu E et al. | โ | 2022 | โ |
| Blood gene expression risk profiles and interstitial lung abnormalities: COPDGene and ECLIPSE cohort studies. | Moll M et al. | โ | 2022 | โ |
| Blood miRNAs Are Linked to Frequent Asthma Exacerbations in Childhood Asthma and Adult COPD. | Tiwari A et al. | โ | 2022 | โ |
| Blood RNA sequencing shows overlapping gene expression across COPD phenotype domains. | Ghosh AJ et al. | โ | 2022 | โ |
| Chronotropic index during 6-minute walk and acute respiratory events in COPDGene. | Macdonald DM et al. | โ | 2022 | โ |
| Clinical Characteristics of Non-Smoking Chronic Obstructive Pulmonary Disease Patients: Findings from the KOCOSS Cohort. | Choi JY et al. | โ | 2022 | โ |
| Clinically Significant and Comorbid Anxiety and Depression Symptoms Predict Severe Respiratory Exacerbations in Smokers: A <i>Post Hoc</i> Analysis of the COPDGene and SPIROMICS Cohorts. | Iyer AS et al. | โ | 2022 | โ |
| Cluster activation mapping with application to computed tomography scans of the lung. | Ryan SM et al. | โ | 2022 | โ |
| Clustering-based COPD subtypes have distinct longitudinal outcomes and multi-omics biomarkers. | Gregory A et al. | โ | 2022 | โ |
| CNN-based Deformable Registration Facilitates Fast and Accurate Air Trapping Measurements at Inspiratory and Expiratory CT. | Hasenstab KA et al. | โ | 2022 | โ |
| Collaborative Cohort of Cohorts for COVID-19 Research (C4R) Study: Study Design. | Oelsner EC et al. | โ | 2022 | โ |
| Computed Tomography Features of Lung Structure Have Utility for Differentiating Malignant and Benign Pulmonary Nodules. | Uthoff JM et al. | โ | 2022 | โ |
| Covariate adjustment of spirometric and smoking phenotypes: The potential of neural network models. | Voorhies K et al. | โ | 2022 | โ |
| Deep Learning Assessment of Emphysema Progression at CT Predicts Outcomes. | Grenier PA | โ | 2022 | โ |
| Depressive and anxiety symptoms in patients with COPD: A network analysis. | Yohannes AM et al. | โ | 2022 | โ |
| Development of a Blood-based Transcriptional Risk Score for Chronic Obstructive Pulmonary Disease. | Moll M et al. | โ | 2022 | โ |
| Effective Subject Representation based on Multi-omics Disease Networks using Graph Embedding. | Hussein S et al. | โ | 2022 | โ |
| Emphysema Progression at CT by Deep Learning Predicts Functional Impairment and Mortality: Results from the COPDGene Study. | Oh AS et al. | โ | 2022 | โ |
| GAWMerge expands GWAS sample size and diversity by combining array-based genotyping and whole-genome sequencing. | Mathur R et al. | โ | 2022 | โ |
| Gene-Based Association Tests Using New Polygenic Risk Scores and Incorporating Gene Expression Data. | Yan S et al. | โ | 2022 | โ |
| Hierarchical Amortized GAN for 3D High Resolution Medical Image Synthesis. | Sun L et al. | โ | 2022 | โ |
| Identifying Individual Medications Affecting Pulmonary Outcomes When Multiple Medications are Present. | Li Y et al. | โ | 2022 | โ |
| Improved Detection of Chronic Obstructive Pulmonary Disease at Chest CT Using the Mean Curvature of Isophotes. | Savadjiev P et al. | โ | 2022 | โ |
| Increased chest CT derived bone and muscle measures capture markers of improved morbidity and mortality in COPD. | Wilson AC et al. | โ | 2022 | โ |
| Interstitial lung abnormalities are associated with decreased mean telomere length. | Putman RK et al. | โ | 2022 | โ |
| Interstitial Lung Abnormalities, Emphysema, and Spirometry in Smokers. | Menon AA et al. | โ | 2022 | โ |
| Kidney and lung in pathology: mechanisms and clinical implications. | Satta E et al. | โ | 2022 | โ |
| Knowledge Distillation via Constrained Variational Inference. | Saeedi A et al. | โ | 2022 | โ |
| Longitudinal Association Between Muscle Loss and Mortality in Ever Smokers. | Mason SE et al. | โ | 2022 | โ |
| <i>C</i> <i>FTR</i> variants are associated with chronic bronchitis in smokers. | Saferali A et al. | โ | 2022 | โ |
| Lung tissue shows divergent gene expression between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. | Ghosh AJ et al. | โ | 2022 | โ |
| Machine Learning Prediction of Progression in Forced Expiratory Volume in 1 Second in the COPDGeneยฎ Study. | Boueiz A et al. | โ | 2022 | โ |
| Mechanism-aware imputation: a two-step approach in handling missing values in metabolomics. | Dekermanjian JP et al. | โ | 2022 | โ |
| Metabolome Features of COPD: A Scoping Review. | Godbole S et al. | โ | 2022 | โ |
| New Guidelines for Bronchodilator Responsiveness in COPD: A Test in Search of a Use. | Bhatt SP et al. | โ | 2022 | โ |
| Optimism is associated with respiratory symptoms and functional status in chronic obstructive pulmonary disease. | Koo HK et al. | โ | 2022 | โ |
| Origins of and lessons from quantitative functional X-ray computed tomography of the lung. | Hoffman EA | โ | 2022 | โ |
| Phenotypic Heterogeneity in Chronic Obstructive Pulmonary Disease. | Kaul M et al. | โ | 2022 | โ |
| Photon-counting CT versus conventional CT for COPD quantifications: intra-scanner optimization and inter-scanner assessments using virtual imaging trials. | Sotoudeh-Paima S et al. | โ | 2022 | โ |
| Physical Activity, Muscle Oxidative Capacity, and Coronary Artery Calcium in Smokers with and without COPD. | Tiller NB et al. | โ | 2022 | โ |
| Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans. | Klont F et al. | โ | 2022 | โ |
| Predicting COPD Progression in Current and Former Smokers Using a Joint Model for Forced Expiratory Volume in 1 Second and Forced Expiratory Volume in 1 Second to Forced Vital Capacity Ratio. | Strand M et al. | โ | 2022 | โ |
| Quantitative imaging analysis detects subtle airway abnormalities in symptomatic military deployers. | Zell-Baran LM et al. | โ | 2022 | โ |
| Racial and Ethnic Minorities Have a Lower Prevalence of Airflow Obstruction than Non-Hispanic Whites. | Sood A et al. | โ | 2022 | โ |
| Review and classification of AI-enabled COVID-19 CT imaging models based on computer vision tasks. | Hassan H et al. | โ | 2022 | โ |
| Robust integrative biclustering for multi-view data. | Zhang W et al. | โ | 2022 | โ |
| Robust Measures of Image-Registration-Derived Lung Biomechanics in SPIROMICS. | Pan Y et al. | โ | 2022 | โ |
| Sex Differences in Airways at Chest CT: Results from the COPDGene Cohort. | Bhatt SP et al. | โ | 2022 | โ |
| Significant Spirometric Transitions and Preserved Ratio Impaired Spirometry Among Ever Smokers. | Wan ES et al. | โ | 2022 | โ |
| Single-material beam hardening correction via an analytical energy response model for diagnostic CT. | Haase V et al. | โ | 2022 | โ |
| sJIVE: Supervised Joint and Individual Variation Explained. | Palzer EF et al. | โ | 2022 | โ |
| Strain Analysis in Patients at High-Risk for COPD Using Four-Dimensional Dynamic-Ventilation CT. | Xu Y et al. | โ | 2022 | โ |
| The Severity of Functional Small Airway Disease in Military Personnel with Constrictive Bronchiolitis as Measured by Quantitative Computed Tomography. | Davis CW et al. | โ | 2022 | โ |
| Traction Bronchiectasis/Bronchiolectasis on CT Scans in Relationship to Clinical Outcomes and Mortality: The COPDGene Study. | Hata A et al. | โ | 2022 | โ |
| Unique and shared systemic biomarkers for emphysema in Alpha-1 Antitrypsin deficiency and chronic obstructive pulmonary disease. | Serban KA et al. | โ | 2022 | โ |
| Unsupervised Learning Identifies Computed Tomographic Measurements as Primary Drivers of Progression, Exacerbation, and Mortality in Chronic Obstructive Pulmonary Disease. | Yuan NF et al. | โ | 2022 | โ |
| Unsupervised segmentation and quantification of COVID-19 lesions on computed Tomography scans using CycleGAN. | Connell M et al. | โ | 2022 | โ |
| Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program. | Wheeler MM et al. | โ | 2022 | โ |
| A CT-Based Automated Algorithm for Airway Segmentation Using Freeze-and-Grow Propagation and Deep Learning. | Nadeem SA et al. | โ | 2021 | โ |
| A novel locus for exertional dyspnoea in childhood asthma. | Lee S et al. | โ | 2021 | โ |
| A Prospective Cohort Study to Assess Obstructive Respiratory Disease Phenotypes and Endotypes in Japan: The TRAIT Study Design. | Hizawa N et al. | โ | 2021 | โ |
| A review of deep learning in medical imaging: Imaging traits, technology trends, case studies with progress highlights, and future promises. | Zhou SK et al. | โ | 2021 | โ |
| Assessing bronchodilator response by changes in per cent predicted forced expiratory volume in one second. | Ioachimescu OC et al. | โ | 2021 | โ |
| Association between Inhaled Corticosteroids and Expiratory Central Airway Collapse in Smokers. | Hudali TH et al. | โ | 2021 | โ |
| Association of Systemic Inflammation with Depressive Symptoms in Individuals with COPD. | Strollo HC et al. | โ | 2021 | โ |
| A systematic analysis of protein-altering exonic variants in chronic obstructive pulmonary disease. | Moll M et al. | โ | 2021 | โ |
| A System for Phenotype Harmonization in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Program. | Stilp AM et al. | โ | 2021 | โ |
| Automated Assessment of COVID-19 Reporting and Data System and Chest CT Severity Scores in Patients Suspected of Having COVID-19 Using Artificial Intelligence. | Lessmann N et al. | โ | 2021 | โ |
| Automated CT Staging of Chronic Obstructive Pulmonary Disease Severity for Predicting Disease Progression and Mortality with a Deep Learning Convolutional Neural Network. | Hasenstab KA et al. | โ | 2021 | โ |
| Can contrastive learning avoid shortcut solutions? | Robinson J et al. | โ | 2021 | โ |
| Caution against examining the role of reverse causality in Mendelian Randomization. | Lutz SM et al. | โ | 2021 | โ |
| Chronic Bronchitis in COPD Patients Creates Worse Symptom Burden Regardless of the Presence of Bronchiectasis in the COPDGene Cohort. | Bohn O et al. | โ | 2021 | โ |
| Cigarette smoking-associated isoform switching and 3' UTR lengthening via alternative polyadenylation. | Xu Z et al. | โ | 2021 | โ |
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| Comparison of CT Lung Density Measurements between Standard Full-Dose and Reduced-Dose Protocols. | Hatt CR et al. | โ | 2021 | โ |
| Computed Tomography-based Airway Surface Area-to-Volume Ratio for Phenotyping Airway Remodeling in Chronic Obstructive Pulmonary Disease. | Bodduluri S et al. | โ | 2021 | โ |
| Context Matters: Graph-based Self-supervised Representation Learning for Medical Images. | Sun L et al. | โ | 2021 | โ |
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| CT image segmentation for inflamed and fibrotic lungs using a multi-resolution convolutional neural network. | Gerard SE et al. | โ | 2021 | โ |
| CT Pulmonary Vessels and MRI Ventilation in Chronic Obstructive Pulmonary Disease: Relationship with worsening FEV<sub>1</sub> in the TINCan cohort study. | Barker AL et al. | โ | 2021 | โ |
| Daily Activities: The Impact of COPD and Cognitive Dysfunction. | Brunette AM et al. | โ | 2021 | โ |
| Deterioration and Mortality Risk of COPD Patients Not Fitting into Standard GOLD Categories: Results of the COSYCONET Cohort. | Mayerhofer B et al. | โ | 2021 | โ |
| Determinants of Lung Fissure Completeness. | van der Molen MC et al. | โ | 2021 | โ |
| Development of the Advancing the Patient Experience in COPD Registry: A Modified Delphi Study. | Edwards CL et al. | โ | 2021 | โ |
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| Distinguishing Smoking-Related Lung Disease Phenotypes Via Imaging and Molecular Features. | Billatos E et al. | โ | 2021 | โ |
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| Longitudinal airway remodeling in active and past smokers in a lung cancer screening population. | Jobst BJ et al. | โ | 2019 | โ |
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| Machine learning approach for distinguishing malignant and benign lung nodules utilizing standardized perinodular parenchymal features from CT. | Uthoff J et al. | โ | 2019 | โ |
| metaFARVAT: An Efficient Tool for Meta-Analysis of Family-Based, Case-Control, and Population-Based Rare Variant Association Studies. | Wang L et al. | โ | 2019 | โ |
| MM ALGORITHMS FOR VARIANCE COMPONENT ESTIMATION AND SELECTION IN LOGISTIC LINEAR MIXED MODEL. | Hu L et al. | โ | 2019 | โ |
| MM Algorithms For Variance Components Models. | Zhou H et al. | โ | 2019 | โ |
| Mortality and Exacerbations by Global Initiative for Chronic Obstructive Lung Disease Groups ABCD: 2011 Versus 2017 in the COPDGeneยฎ Cohort. | Criner RN et al. | โ | 2019 | โ |
| Multi-target natural products as alternatives against oxidative stress in Chronic Obstructive Pulmonary Disease (COPD). | Gonรงalves PB et al. | โ | 2019 | โ |
| Noninvasive Imaging Biomarker Identifies Small Airway Damage in Severe Chronic Obstructive Pulmonary Disease. | Vasilescu DM et al. | โ | 2019 | โ |
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| Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke. | Hikichi M et al. | โ | 2019 | โ |
| Peripheral Blood Eosinophil as a Biomarker in Outcomes of Acute Exacerbation of Chronic Obstructive Pulmonary Disease. | Wu HX et al. | โ | 2019 | โ |
| Pharmacogenomics of chronic obstructive pulmonary disease. | Hersh CP | โ | 2019 | โ |
| Physiologic Insights from the COPD Genetic Epidemiology Study. | Stringer WW et al. | โ | 2019 | โ |
| Post-imaging pulmonary nodule mathematical prediction models: are they clinically relevant? | Uthoff J et al. | โ | 2019 | โ |
| Pre-analytic Considerations for Mass Spectrometry-Based Untargeted Metabolomics Data. | Reinhold D et al. | โ | 2019 | โ |
| Pulmonary Subtypes Exhibit Differential Global Initiative for Chronic Obstructive Lung Disease Spirometry Stage Progression: The COPDGeneยฎ Study. | Young KA et al. | โ | 2019 | โ |
| Quantitative CT analysis in patients with pulmonary emphysema: is lung function influenced by concomitant unspecific pulmonary fibrosis? | Feldhaus FW et al. | โ | 2019 | โ |
| Quantitative CT of Interstitial Lung Disease. | Newell JD et al. | โ | 2019 | โ |
| Radiomic measures from chest high-resolution computed tomography associated with lung function in sarcoidosis. | Ryan SM et al. | โ | 2019 | โ |
| Real-world use of rescue inhaler sensors, electronic symptom questionnaires and physical activity monitors in COPD. | Bowler R et al. | โ | 2019 | โ |
| Redefining DISH: A Catalyst for Advancement of Research? | Block JJ | โ | 2019 | โ |
| Reduced Attention in Former Smokers with and without COPD. | Croghan A et al. | โ | 2019 | โ |
| Relationship between current smoking, visual CT findings and emphysema index in cigarette smokers. | Jou SS et al. | โ | 2019 | โ |
| Relationship of spirometric, body plethysmographic, and diffusing capacity parameters to emphysema scores derived from CT scans. | Kahnert K et al. | โ | 2019 | โ |
| Reprint of: Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers. | Labaki WW et al. | โ | 2019 | โ |
| RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD. | Morrow JD et al. | โ | 2019 | โ |
| S100A8 Protects Human Primary Alveolar Type II Cells against Injury and Emphysema. | Lin CR et al. | โ | 2019 | โ |
| Spirometric assessment of emphysema presence and severity as measured by quantitative CT and CT-based radiomics in COPD. | Occhipinti M et al. | โ | 2019 | โ |
| Subjects with diffuse idiopathic skeletal hyperostosis have an increased burden of coronary artery disease: An evaluation in the COPDGene cohort. | Oudkerk SF et al. | โ | 2019 | โ |
| Subtypes of COPD Have Unique Distributions and Differential Risk of Mortality. | Young KA et al. | โ | 2019 | โ |
| Symptoms of anxiety and depression and use of anxiolytic-hypnotics and antidepressants in current and former smokers with and without COPD - A cross sectional analysis of the COPDGene cohort. | Iyer AS et al. | โ | 2019 | โ |
| Test Gene-Environment Interactions for Multiple Traits in Sequencing Association Studies. | Zhang J et al. | โ | 2019 | โ |
| The Peak Index: Exploring the Heterogeneity of Airflow Obstruction, Using Simple Spirometry. | Ostridge K | โ | 2019 | โ |
| The Peak Index: Spirometry Metric for Airflow Obstruction Severity and Heterogeneity. | Bhatt SP et al. | โ | 2019 | โ |
| The Pressing Need to Redefine "COPD". | Barnes PJ et al. | โ | 2019 | โ |
| The Severity of Oxidative Stress in Comorbid Chronic Obstructive Pulmonary Disease (COPD) and Hypertension: Does it Depend On ACE and AGT Gene Polymorphisms? | Marushchak M et al. | โ | 2019 | โ |
| The St. George's Respiratory Questionnaire Definition of Chronic Bronchitis May Be aย Better Predictor of COPD Exacerbations Compared With the Classic Definition. | Kim V et al. | โ | 2019 | โ |
| Unsupervised discovery of phenotype-specific multi-omics networks. | Shi WJ et al. | โ | 2019 | โ |
| Using a spatial point process framework to characterize lung computed tomography scans. | Vestal BE et al. | โ | 2019 | โ |
| Validated imaging biomarkers as decision-making tools in clinical trials and routine practice: current status and recommendations from the EIBALL* subcommittee of the European Society of Radiology (ESR). | deSouza NM et al. | โ | 2019 | โ |
| Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers. | Labaki WW et al. | โ | 2019 | โ |
| A Bayesian Approach for Learning Gene Networks Underlying Disease Severity in COPD. | Shaddox E et al. | โ | 2018 | โ |
| Accurate and adaptive imputation of summary statistics in mixed-ethnicity cohorts. | Togninalli M et al. | โ | 2018 | โ |
| A hierarchical clustering method for dimension reduction in joint analysis of multiple phenotypes. | Liang X et al. | โ | 2018 | โ |
| Airway fractal dimension predicts respiratory morbidity and mortality in COPD. | Bodduluri S et al. | โ | 2018 | โ |
| A novel method to test associations between a weighted combination of phenotypes and genetic variants. | Zhu H et al. | โ | 2018 | โ |
| A prototypic small molecule database for bronchoalveolar lavage-based metabolomics. | Walmsley S et al. | โ | 2018 | โ |
| Artificial Intelligence and Chest Imaging. Will Deep Learning Make Us Smarter? | Labaki WW et al. | โ | 2018 | โ |
| Association between Emphysema and Chronic Obstructive Pulmonary Disease Outcomes in the COPDGene and SPIROMICS Cohorts: A Post Hoc Analysis of Two Clinical Trials. | Han MK et al. | โ | 2018 | โ |
| Association between multidrug resistance-1 C3435T gene polymorphism and right ventricular dysfunction in patients with chronic obstructive pulmonary disease: cross-sectional study. | Yรผcel O et al. | โ | 2018 | โ |
| Association of low income with pulmonary disease progression in smokers with and without chronic obstructive pulmonary disease. | Lowe KE et al. | โ | 2018 | โ |
| Association of thrombocytosis with COPD morbidity: the SPIROMICS and COPDGene cohorts. | Fawzy A et al. | โ | 2018 | โ |
| Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline: Five-Year Follow-up in Adult Smokers From the COPDGene Study. | Hayden LP et al. | โ | 2018 | โ |
| Autocalibration method for non-stationary CT bias correction. | Vegas-Sรกnchez-Ferrero G et al. | โ | 2018 | โ |
| Automated Agatston Score Computation in non-ECG Gated CT Scans Using Deep Learning. | Cano-Espinosa C et al. | โ | 2018 | โ |
| Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease. | Yun JH et al. | โ | 2018 | โ |
| Bronchodilator responsiveness or reversibility in asthma and COPD - a need for clarity. | Barjaktarevic I et al. | โ | 2018 | โ |
| Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort. | Bhatt SP et al. | โ | 2018 | โ |
| Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study. | Hayden LP et al. | โ | 2018 | โ |
| Coronary Artery Calcium on Noncontrast Thoracic Computerized Tomography Scans and All-Cause Mortality. | Budoff MJ et al. | โ | 2018 | โ |
| CT-based Visual Classification of Emphysema: Association with Mortality in the COPDGene Study. | Lynch DA et al. | โ | 2018 | โ |
| CT densitometry in emphysema: a systematic review of its clinical utility. | Crossley D et al. | โ | 2018 | โ |
| CT-measured lung air-trapping is associated with higher carotid artery stiffness in individuals with chronic obstructive pulmonary disease. | Luehrs RE et al. | โ | 2018 | โ |
| CT measurements of central pulmonary vasculature as predictors of severe exacerbation in COPD. | Rho JY et al. | โ | 2018 | โ |
| Deep learning for biomarker regression: application to osteoporosis and emphysema on chest CT scans. | Gonzรกlez G et al. | โ | 2018 | โ |
| Defining Impaired Respiratory Health. A Paradigm Shift for Pulmonary Medicine. | Reyfman PA et al. | โ | 2018 | โ |
| Design and application of an MR reference phantom for multicentre lung imaging trials. | Triphan SMF et al. | โ | 2018 | โ |
| Development of a pulmonary imaging biomarker pipeline for phenotyping of chronic lung disease. | Guo F et al. | โ | 2018 | โ |
| Diffeomorphic Lung Registration Using Deep CNNs and Reinforced Learning. | Onieva JO et al. | โ | 2018 | โ |
| Disease Severity Dependence of the Longitudinal Association Between CT Lung Density and Lung Function in Smokers. | Diaz AA et al. | โ | 2018 | โ |
| Disease Staging and Prognosis in Smokers Using Deep Learning in Chest Computed Tomography. | Gonzรกlez G et al. | โ | 2018 | โ |
| Effect of smoking cessation on quantitative computed tomography in smokers at risk in a lung cancer screening population. | Jobst BJ et al. | โ | 2018 | โ |
| Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene. | Wells JM et al. | โ | 2018 | โ |
| Emphysematous and Nonemphysematous Gas Trapping in Chronic Obstructive Pulmonary Disease: Quantitative CT Findings and Pulmonary Function. | Occhipinti M et al. | โ | 2018 | โ |
| Features of COPD as Predictors of Lungย Cancer. | Carr LL et al. | โ | 2018 | โ |
| Genetic correlation between smoking behaviors and schizophrenia. | Hartz SM et al. | โ | 2018 | โ |
| Genetic variants predicting aerobic capacity response to training are also associated with skeletal muscle oxidative capacity in moderate-to-severe COPD. | Adami A et al. | โ | 2018 | โ |
| Genotype imputation performance of three reference panels using African ancestry individuals. | Vergara C et al. | โ | 2018 | โ |
| Grading Severity of Productive Cough Based on Symptoms and Airflow Obstruction. | Vazquez Guillamet R et al. | โ | 2018 | โ |
| Identification of Chronic Obstructive Pulmonary Disease Axes That Predict All-Cause Mortality: The COPDGene Study. | Kinney GL et al. | โ | 2018 | โ |
| Impact of advanced detector technology and iterative reconstruction on low-dose quantitative assessment of lung computed tomography density in a biological lung model. | Hammond E et al. | โ | 2018 | โ |
| Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort. | Ash SY et al. | โ | 2018 | โ |
| Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression. | Boueiz A et al. | โ | 2018 | โ |
| Longitudinal Modeling of Lung Function Trajectories in Smokers with and without Chronic Obstructive Pulmonary Disease. | Ross JC et al. | โ | 2018 | โ |
| Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study. | Wan ES et al. | โ | 2018 | โ |
| Lung, Fat and Bone: Increased Adiponectin Associates with the Combination of Smoking-Related Lung Disease and Osteoporosis. | Suh YJ et al. | โ | 2018 | โ |
| Metabolomics and transcriptomics pathway approach reveals outcome-specific perturbations in COPD. | Cruickshank-Quinn CI et al. | โ | 2018 | โ |
| Morphological and functional properties of the conducting human airways investigated by in vivo computed tomography and in vitro MRI. | Van de Moortele T et al. | โ | 2018 | โ |
| Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function. | Wyss AB et al. | โ | 2018 | โ |
| Multiorgan structures detection using deep convolutional neural networks. | Onieva JO et al. | โ | 2018 | โ |
| Multi-structure Segmentation from Partially Labeled Datasets. Application to Body Composition Measurements on CT Scans. | Gonzรกlez G et al. | โ | 2018 | โ |
| New Spirometry Indices for Detecting Mild Airflow Obstruction. | Bhatt SP et al. | โ | 2018 | โ |
| On the Relevance of the Loss Function in the Agatston Score Regression from Non-ECG Gated CT Scans. | Cano-Espinosa C et al. | โ | 2018 | โ |
| Overfitting and Use of Mismatched Cohorts in Deep Learning Models: Preventable Design Limitations. | Mummadi SR et al. | โ | 2018 | โ |
| Paratracheal Paraseptal Emphysema and Expiratory Central Airway Collapse in Smokers. | Copeland CR et al. | โ | 2018 | โ |
| Pectoralis muscle area and mortality in smokers without airflow obstruction. | Diaz AA et al. | โ | 2018 | โ |
| Pulmonary Artery-Vein Classification in CT Images Using Deep Learning. | Nardelli P et al. | โ | 2018 | โ |
| Pulmonary quantitative CT imaging in focal and diffuse disease: current research and clinical applications. | Silva M et al. | โ | 2018 | โ |
| Pulmonary vascular pruning in smokers with bronchiectasis. | Diaz AA et al. | โ | 2018 | โ |
| Quantitative computed tomography phenotypes, spirometric parameters, and episodes of exacerbation in heavy smokers: An analysis from South America. | Barros MC et al. | โ | 2018 | โ |
| Race and Gender Disparities are Evident in COPD Underdiagnoses Across all Severities of Measured Airflow Obstruction. | Mamary AJ et al. | โ | 2018 | โ |
| Radiographic Emphysema, Circulating Bone Biomarkers, and Progressive Bone Mineral Density Loss in Smokers. | Bon J et al. | โ | 2018 | โ |
| Rare Variants in Known Susceptibility Loci and Their Contribution to Risk of Lung Cancer. | Liu Y et al. | โ | 2018 | โ |
| RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs. | Yeo J et al. | โ | 2018 | โ |
| Significance of Low-Attenuation Cluster Analysis on Quantitative CT in the Evaluation of Chronic Obstructive Pulmonary Disease. | Nambu A et al. | โ | 2018 | โ |
| Small airway segmentation in thoracic computed tomography scans: a machine learning approach. | Bian Z et al. | โ | 2018 | โ |
| Smoking duration alone provides stronger risk estimates of chronic obstructive pulmonary disease than pack-years. | Bhatt SP et al. | โ | 2018 | โ |
| Spirometric Volumes and Breathlessness across Levels of Airflow Limitation: The COPDGene Study. | Ekstrรถm M et al. | โ | 2018 | โ |
| Subject2Vec: Generative-Discriminative Approach from a Set of Image Patches to a Vector. | Singla S et al. | โ | 2018 | โ |
| Subjective cognitive complaints and neuropsychological performance in former smokers with and without chronic obstructive pulmonary disease. | Brunette AM et al. | โ | 2018 | โ |
| Systemic Markers of Adaptive and Innate Immunity Are Associated with Chronic Obstructive Pulmonary Disease Severity and Spirometric Disease Progression. | Halper-Stromberg E et al. | โ | 2018 | โ |
| Testing an optimally weighted combination of common and/or rare variants with multiple traits. | Wang Z et al. | โ | 2018 | โ |
| The Association Between Technology Use and Health Status in a Chronic Obstructive Pulmonary Disease Cohort: Multi-Method Study. | Witry M et al. | โ | 2018 | โ |
| The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial. | Patel NR et al. | โ | 2018 | โ |
| Total Airway Count on Computed Tomography and the Risk of Chronic Obstructive Pulmonary Disease Progression. Findings from a Population-based Study. | Kirby M et al. | โ | 2018 | โ |
| Transfer Learning for Multicenter Classification of Chronic Obstructive Pulmonary Disease. | Cheplygina V et al. | โ | 2018 | โ |
| Visual Estimate of Coronary Artery Calcium Predicts Cardiovascular Disease in COPD. | Bhatt SP et al. | โ | 2018 | โ |
| Whole exome sequencing analysis in severe chronic obstructive pulmonary disease. | Qiao D et al. | โ | 2018 | โ |
| Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease. | Prokopenko D et al. | โ | 2018 | โ |
| Women manifest more severe COPD symptoms across the life course. | DeMeo DL et al. | โ | 2018 | โ |
| A Bayesian Nonparametric Model for Disease Subtyping: Application to Emphysema Phenotypes. | Ross JC et al. | โ | 2017 | โ |
| Acute Exacerbations and Lung Function Loss in Smokers with and without Chronic Obstructive Pulmonary Disease. | Dransfield MT et al. | โ | 2017 | โ |
| A general approach to testing for pleiotropy with rare and common variants. | Lutz SM et al. | โ | 2017 | โ |
| A Likelihood-Free Approach for Characterizing Heterogeneous Diseases in Large-Scale Studies. | Schabdach J et al. | โ | 2017 | โ |
| Alpha-1 Antitrypsin PiMZ Genotype Is Associated with Chronic Obstructive Pulmonary Disease in Two Racial Groups. | Foreman MG et al. | โ | 2017 | โ |
| Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort. | Hastie AT et al. | โ | 2017 | โ |
| Asthma-chronic obstructive pulmonary disease overlap syndrome: a controversial concept. | Rodrigo GJ et al. | โ | 2017 | โ |
| Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD. | Bihlet AR et al. | โ | 2017 | โ |
| Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts. | Keene JD et al. | โ | 2017 | โ |
| Biomechanical CT metrics are associated with patient outcomes in COPD. | Bodduluri S et al. | โ | 2017 | โ |
| Bronchoarterial ratio in never-smokers adults: Implications for bronchial dilation definition. | Diaz AA et al. | โ | 2017 | โ |
| Cardiac Morphometry on Computed Tomography and Exacerbation Reduction with ฮฒ-Blocker Therapy in Chronic Obstructive Pulmonary Disease. | Bhatt SP et al. | โ | 2017 | โ |
| Chest computed tomography-derived lowย fat-free mass index and mortality inย COPD. | McDonald MN et al. | โ | 2017 | โ |
| Chronic obstructive pulmonary disease is independently associated with hypertension in men: A survey design analysis using nationwide survey data. | Kim SH et al. | โ | 2017 | โ |
| Clinical and Genetic Associations of Objectively Identified Interstitial Changes inย Smokers. | Ash SY et al. | โ | 2017 | โ |
| Comparison of low- and ultralow-dose computed tomography protocols for quantitative lung and airway assessment. | Hammond E et al. | โ | 2017 | โ |
| Computed Tomography Measure of Lung at Risk and Lung Function Decline in Chronic Obstructive Pulmonary Disease. | Bhatt SP et al. | โ | 2017 | โ |
| Computed tomography quantification of tracheal abnormalities in COPD and their influence on airflow limitation. | Gallardo Estrella L et al. | โ | 2017 | โ |
| CT-Based Local Distribution Metric Improves Characterization of COPD. | Hoff BA et al. | โ | 2017 | โ |
| CT Image Enhancement for Feature Detection and Localization. | Nardelli P et al. | โ | 2017 | โ |
| CT imaging of chronic obstructive pulmonary disease: insights, disappointments, and promise. | Washko GR et al. | โ | 2017 | โ |
| CT Quantification of Lungs and Airways in Normal Korean Subjects. | Kim SS et al. | โ | 2017 | โ |
| Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts. | Castaldi PJ et al. | โ | 2017 | โ |
| Electronic Cigarette Use in US Adults at Risk for or with COPD: Analysis from Two Observational Cohorts. | Bowler RP et al. | โ | 2017 | โ |
| Emerging inhaled long-acting beta-2 adrenoceptor agonists for the treatment of COPD. | Monaco TJ et al. | โ | 2017 | โ |
| Estimating drivers of cell state transitions using gene regulatory network models. | Schlauch D et al. | โ | 2017 | โ |
| Examination of the Involvement of Cholinergic-Associated Genes in Nicotine Behaviors in European and African Americans. | Melroy-Greif WE et al. | โ | 2017 | โ |
| Examining the Effects of Age on Health Outcomes of Chronic Obstructive Pulmonary Disease: Results From the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease Study and Evaluation of Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate Endpoints Cohorts. | Parulekar AD et al. | โ | 2017 | โ |
| Exclusion of emphysematous lung from dose-volume estimates of risk improves prediction of radiation pneumonitis. | Uchida Y et al. | โ | 2017 | โ |
| External Validation of the COmorbidity Test. | Villalobos N et al. | โ | 2017 | โ |
| GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease. | Martinez CH et al. | โ | 2017 | โ |
| Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects. | Busch R et al. | โ | 2017 | โ |
| Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. | Wain LV et al. | โ | 2017 | โ |
| Genome-wide genetic heterogeneity discovery with categorical covariates. | Llinares-Lรณpez F et al. | โ | 2017 | โ |
| Handgrip Strength in Chronic Obstructive Pulmonary Disease. Associations with Acute Exacerbations and Body Composition. | Martinez CH et al. | โ | 2017 | โ |
| Higher BMI is associated with higher expiratory airflow normalised for lung volume (FEF25-75/FVC) in COPD. | Abston E et al. | โ | 2017 | โ |
| Improving airway segmentation in computed tomography using leak detection with convolutional networks. | Charbonnier JP et al. | โ | 2017 | โ |
| Inhaled Steroids and Active Smoking Drive Chronic Obstructive Pulmonary Disease Symptoms and Biomarkers to a Greater Degree Than Airflow Limitation. | Silkoff PE et al. | โ | 2017 | โ |
| Lung Mass in Smokers. | Washko GR et al. | โ | 2017 | โ |
| Management of COPD: Is there a role for quantitative imaging? | Kirby M et al. | โ | 2017 | โ |
| Manifold Learning of COPD. | Bragman FJS et al. | โ | 2017 | โ |
| Meta-analysis of peripheral blood gene expression modules for COPD phenotypes. | Reinhold D et al. | โ | 2017 | โ |
| Metabolomic similarities between bronchoalveolar lavage fluid and plasma in humans and mice. | Cruickshank-Quinn C et al. | โ | 2017 | โ |
| Mortality prediction in idiopathic pulmonary fibrosis: evaluation of computer-based CT analysis with conventional severity measures. | Jacob J et al. | โ | 2017 | โ |
| Multiple biomarkers predict disease severity, progression and mortality in COPD. | Zemans RL et al. | โ | 2017 | โ |
| Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma. | Farahi N et al. | โ | 2017 | โ |
| Obesity Is Associated With Increased Morbidity in Moderate to Severe COPD. | Lambert AA et al. | โ | 2017 | โ |
| Prediction models for exacerbations in different COPD patient populations: comparing results of five large data sources. | Hoogendoorn M et al. | โ | 2017 | โ |
| Predictive value of prebronchodilator and postbronchodilator spirometry for COPD features and outcomes. | Fortis S et al. | โ | 2017 | โ |
| Pulmonary Lobe Segmentation With Probabilistic Segmentation of the Fissures and a Groupwise Fissure Prior. | Bragman FJS et al. | โ | 2017 | โ |
| Quantitative CT Measures of Bronchiectasis in Smokers. | Diaz AA et al. | โ | 2017 | โ |
| Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD. | Adami A et al. | โ | 2017 | โ |
| RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking. | Parker MM et al. | โ | 2017 | โ |
| Role of dual bronchodilators in COPD: A review of the current evidence for indacaterol/glycopyrronium. | Ficker JH et al. | โ | 2017 | โ |
| [Severity classification of chronic obstructive pulmonary disease based on deep learning]. | Ying J et al. | โ | 2017 | โ |
| Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. | Hardin M et al. | โ | 2017 | โ |
| Signs of Gas Trapping in Normal Lung Density Regions in Smokers. | Bodduluri S et al. | โ | 2017 | โ |
| Susceptibility to Childhood Pneumonia: A Genome-Wide Analysis. | Hayden LP et al. | โ | 2017 | โ |
| The Contribution of Small Airway Obstruction to the Pathogenesis of Chronic Obstructive Pulmonary Disease. | Hogg JC et al. | โ | 2017 | โ |
| The COPD Biomarkers Qualification Consortium Database: Baseline Characteristics of the St George's Respiratory Questionnaire Dataset. | Tabberer M et al. | โ | 2017 | โ |
| The diagnosis of idiopathic pulmonary fibrosis: current and future approaches. | Martinez FJ et al. | โ | 2017 | โ |
| The effects of iterative reconstruction and kernel selection on quantitative computed tomography measures of lung density. | Rodriguez A et al. | โ | 2017 | โ |
| The <i>MUC5B</i> promoter polymorphism is associated with specific interstitial lung abnormality subtypes. | Putman RK et al. | โ | 2017 | โ |
| The Objective Identification and Quantification of Interstitial Lung Abnormalities in Smokers. | Ash SY et al. | โ | 2017 | โ |
| The value of blood cytokines and chemokines in assessing COPD. | Bradford E et al. | โ | 2017 | โ |
| Through the Looking Glass and What Was Found There: Imaging Biomarkers of Chronic Obstructive Pulmonary Disease. | Capaldi DPI et al. | โ | 2017 | โ |
| Ventricular Geometry From Non-contrast Non-ECG-gated CT Scans: An Imaging Marker of Cardiopulmonary Disease in Smokers. | Rahaghi FN et al. | โ | 2017 | โ |
| Visual Assessment of Chest Computed Tomographic Images Is Independently Useful for Genetic Association Analysis in Studies of Chronic Obstructive Pulmonary Disease. | Halper-Stromberg E et al. | โ | 2017 | โ |
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| Identifying a Deletion Affecting Total Lung Capacity Among Subjects in the COPDGene Study Cohort. | Begum F et al. | โ | 2016 | โ |
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| Lymphocyte Kv1.3-channels in the pathogenesis of chronic obstructive pulmonary disease: novel therapeutic implications of targeting the channels by commonly used drugs. | Kazama I et al. | โ | 2016 | โ |
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| Abdominal Visceral Adipose Tissue is Associated with Myocardial Infarction in Patients with COPD. | Diaz AA et al. | โ | 2015 | โ |
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| CD4+ T-Cell Profiles and Peripheral Blood Ex-Vivo Responses to T-Cell Directed Stimulation Delineate COPD Phenotypes. | Roberts MEP et al. | โ | 2015 | โ |
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| Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene. | Kim V et al. | โ | 2015 | โ |
| Comparison of acute respiratory events between asthma-COPD overlap syndrome and COPD patients: a population-based cohort study. | Chung WS et al. | โ | 2015 | โ |
| COPD: Do Imaging Measurements of Emphysema and Airway Disease Explain Symptoms and Exercise Capacity? | Kirby M et al. | โ | 2015 | โ |
| CT-Definable Subtypes of Chronic Obstructive Pulmonary Disease: A Statement of the Fleischner Society. | Lynch DA et al. | โ | 2015 | โ |
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| Genome-wide association study revealed a promising region and candidate genes for eggshell quality in an F2 resource population. | Sun C et al. | โ | 2015 | โ |
| Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence. | Hancock DB et al. | โ | 2015 | โ |
| Genome-wide site-specific differential methylation in the blood of individuals with Klinefelter syndrome. | Wan ES et al. | โ | 2015 | โ |
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| Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability. | Zhou JJ et al. | โ | 2015 | โ |
| IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. | Lee JH et al. | โ | 2015 | โ |
| Large trials, new knowledge: the changing face of COPD management. | De Soyza A et al. | โ | 2015 | โ |
| Menthol cigarette smoking in the COPDGene cohort: relationship with COPD, comorbidities and CT metrics. | Park SJ et al. | โ | 2015 | โ |
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| Prevalence and global initiative for chronic obstructive lung disease group distribution of chronic obstructive pulmonary disease detected by preoperative pulmonary function test. | Choi SM et al. | โ | 2015 | โ |
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| Pulmonary artery enlargement is associated with right ventricular dysfunction and loss of blood volume in small pulmonary vessels in chronic obstructive pulmonary disease. | Wells JM et al. | โ | 2015 | โ |
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| Significance of Medication History at the Time of Entry into the COPDGene Study: Relationship with Exacerbation and CT Metrics. | Park SJ et al. | โ | 2015 | โ |
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| The Impact of Sources of Variability on Parametric Response Mapping of Lung CT Scans. | Boes JL et al. | โ | 2015 | โ |
| The Swedish CArdioPulmonary BioImage Study: objectives and design. | Bergstrรถm G et al. | โ | 2015 | โ |
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| Understanding the contribution of native tracheobronchial structure to lung function: CT assessment of airway morphology in never smokers. | Diaz AA et al. | โ | 2015 | โ |
| Acute Exacerbation and Respiratory InfectionS in COPD (AERIS): protocol for a prospective, observational cohort study. | Bourne S et al. | โ | 2014 | โ |
| A Decade of National Heart, Lung, and Blood Institute Programs Supporting COPD Research and Education . | Postow L et al. | โ | 2014 | โ |
| Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study. | Parker MM et al. | โ | 2014 | โ |
| Airway wall thickness is increased in COPD patients with bronchodilator responsiveness. | Kim V et al. | โ | 2014 | โ |
| Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD. | Chu JH et al. | โ | 2014 | โ |
| A simplified score to quantify comorbidity in COPD. | Putcha N et al. | โ | 2014 | โ |
| Association between occupational exposure and lung function, respiratory symptoms, and high-resolution computed tomography imaging in COPDGene. | Marchetti N et al. | โ | 2014 | โ |
| Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks. | McDonald ML et al. | โ | 2014 | โ |
| Cardiovascular disease is associated with COPD severity and reduced functional status and quality of life. | Black-Shinn JL et al. | โ | 2014 | โ |
| Childhood-onset asthma in smokers. association between CT measures of airway size, lung function, and chronic airflow obstruction. | Diaz AA et al. | โ | 2014 | โ |
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| Clinical and computed tomographic predictors of chronic bronchitis in COPD: a cross sectional analysis of the COPDGene study. | Kim V et al. | โ | 2014 | โ |
| Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema. | Castaldi PJ et al. | โ | 2014 | โ |
| Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. | McDonald ML et al. | โ | 2014 | โ |
| Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans. | Putcha N et al. | โ | 2014 | โ |
| Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction. | Bhatt SP et al. | โ | 2014 | โ |
| Computed tomographic measures of airway morphology in smokers and never-smoking normals. | Washko GR et al. | โ | 2014 | โ |
| Computing global minimizers to a constrained B-spline image registration problem from optimal l1 perturbations to block match data. | Castillo E et al. | โ | 2014 | โ |
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| DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease. | Lee JH et al. | โ | 2014 | โ |
| Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. | Wan ES et al. | โ | 2014 | โ |
| FEV(1)/FEV(6) to diagnose airflow obstruction. Comparisons with computed tomography and morbidity indices. | Bhatt SP et al. | โ | 2014 | โ |
| Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. | Lee JH et al. | โ | 2014 | โ |
| Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. | Castaldi PJ et al. | โ | 2014 | โ |
| Hyperpolarized 3He and 129Xe magnetic resonance imaging apparent diffusion coefficients: physiological relevance in older never- and ex-smokers. | Kirby M et al. | โ | 2014 | โ |
| Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort. | Martinez CH et al. | โ | 2014 | โ |
| Integrative genomics of chronic obstructive pulmonary disease. | Hobbs BD et al. | โ | 2014 | โ |
| Lessons from ECLIPSE: a review of COPD biomarkers. | Faner R et al. | โ | 2014 | โ |
| Longitudinal Computed Tomography and Magnetic Resonance Imaging of COPD: Thoracic Imaging Network of Canada (TINCan) Study Objectives. | Kirby M et al. | โ | 2014 | โ |
| MDR-1 gene C/T polymorphism in COPD: data from Aegean part of Turkey. | Toru U et al. | โ | 2014 | โ |
| Multidetector computed tomographic imaging in chronic obstructive pulmonary disease: emphysema and airways assessment. | Litmanovich DE et al. | โ | 2014 | โ |
| Multi-scale analysis of imaging features and its use in the study of COPD exacerbation susceptible phenotypes. | Bragman FJ et al. | โ | 2014 | โ |
| New developments in the assessment of COPD: early diagnosis is key. | Csikesz NG et al. | โ | 2014 | โ |
| Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. | Hersh CP et al. | โ | 2014 | โ |
| On the simultaneous association analysis of large genomic regions: a massive multi-locus association test. | Qiao D et al. | โ | 2014 | โ |
| Parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. | Galbรกn CJ et al. | โ | 2014 | โ |
| Personalized medicine for chronic, complex diseases: chronic obstructive pulmonary disease as an example. | Radder JE et al. | โ | 2014 | โ |
| Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. | Lee JH et al. | โ | 2014 | โ |
| Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease. | Hobbs BD et al. | โ | 2014 | โ |
| Prediction of acute respiratory disease in current and former smokers with and without COPD. | Bowler RP et al. | โ | 2014 | โ |
| Progress in Imaging COPD, 2004 - 2014. | Lynch DA | โ | 2014 | โ |
| Pulmonary 3 T MRI with ultrashort TEs: influence of ultrashort echo time interval on pulmonary functional and clinical stage assessments of smokers. | Ohno Y et al. | โ | 2014 | โ |
| Pulmonary function reduction in diabetes with and without chronic obstructive pulmonary disease. | Kinney GL et al. | โ | 2014 | โ |
| Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study. | McDonald ML et al. | โ | 2014 | โ |
| Radiological correlates and clinical implications of the paradoxical lung function response to ฮฒโ agonists: an observational study. | Bhatt SP et al. | โ | 2014 | โ |
| Risk Factors for Venous Thromboembolism in Chronic Obstructive Pulmonary Disease. | Kim V et al. | โ | 2014 | โ |
| Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. | Cho MH et al. | โ | 2014 | โ |
| Roflumilast : the new orally active, selective phophodiesterase-4 inhibitor, for the treatment of COPD. | Tashkin DP | โ | 2014 | โ |
| Sinogram Affirmed Iterative Reconstruction (SAFIRE) versus weighted filtered back projection (WFBP) effects on quantitative measure in the COPDGene 2 test object. | Sieren JP et al. | โ | 2014 | โ |
| Spherical Topic Models for Imaging Phenotype Discovery in Genetic Studies. | Batmanghelich KN et al. | โ | 2014 | โ |
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| The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes. | Carolan BJ et al. | โ | 2014 | โ |
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| The clinical impact of non-obstructive chronic bronchitis in current and former smokers. | Martinez CH et al. | โ | 2014 | โ |
| Variation of densitometry on computed tomography in COPD--influence of different software tools. | Wielpรผtz MO et al. | โ | 2014 | โ |
| Visual Assessment of CT Findings in Smokers With Nonobstructed Spirometric Abnormalities in The COPDGene<sup>ยฎ</sup> Study. | Kim SS et al. | โ | 2014 | โ |
| A general semi-parametric approach to the analysis of genetic association studies in population-based designs. | Lutz S et al. | โ | 2013 | โ |
| A reference dataset for deformable image registration spatial accuracy evaluation using the COPDgene study archive. | Castillo R et al. | โ | 2013 | โ |
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| Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort. | Agusti A et al. | โ | 2013 | โ |
| Characterizing functional lung heterogeneity in COPD using reference equations for CT scan-measured lobar volumes. | Come CE et al. | โ | 2013 | โ |
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| Chronic obstructive pulmonary disease: lobe-based visual assessment of volumetric CT by Using standard images--comparison with quantitative CT and pulmonary function test in the COPDGene study. | Kim SS et al. | โ | 2013 | โ |
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| Computed tomographic measures of pulmonary vascular morphology in smokers and their clinical implications. | Estรฉpar RS et al. | โ | 2013 | โ |
| Computed tomography density histogram analysis to evaluate pulmonary emphysema in ex-smokers. | Owrangi AM et al. | โ | 2013 | โ |
| Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. | Siedlinski M et al. | โ | 2013 | โ |
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| FAQs about the GOLD 2011 assessment proposal of COPD: a comparative analysis of four different cohorts. | Agusti A et al. | โ | 2013 | โ |
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| Integrative omics approach identifies interleukin-16 as a biomarker of emphysema. | Bowler RP et al. | โ | 2013 | โ |
| Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease. | Aminuddin F et al. | โ | 2013 | โ |
| Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD. | Hersh CP et al. | โ | 2013 | โ |
| Pathophysiology and clinical implications of pulmonary arterial enlargement in COPD. | Wells JM et al. | โ | 2013 | โ |
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