Efficient design for Mendelian randomization studies: subsample and 2-sample instrumental variable estimators.
paper
Cited
Public
- Authors
- Pierce, Brandon L; Burgess, Stephen
- Year
- 2013
- Journal
- American journal of epidemiology
- PMID
- 23863760
- DOI
- 10.1093/aje/kwt084
- PMCID
- PMC3783091
Mendelian randomization (MR) is a method for estimating the causal relationship between an exposure and an outcome using a genetic factor as an instrumental variable (IV) for the exposure. In the traditional MR setting, data on the IV, exposure, and outcome are available for all participants. However, obtaining complete exposure data may be difficult in some settings, due to high measurement costs or lack of appropriate biospecimens. We used simulated data sets to assess statistical power and bias for MR when exposure data are available for a subset (or an independent set) of participants. We show that obtaining exposure data for a subset of participants is a cost-efficient strategy, often having negligible effects on power in comparison with a traditional complete-data analysis. The size of the subset needed to achieve maximum power depends on IV strength, and maximum power is approximately equal to the power of traditional IV estimators. Weak IVs are shown to lead to bias towards the null when the subsample is small and towards the confounded association when the subset is relatively large. Various approaches for confidence interval calculation are considered. These results have important implications for reducing the costs and increasing the feasibility of MR studies.
Power (left) and median standard error (right) of the subsample instrumental-variable (IV) estimate for different values of the causal effect size (Ξ²XY) and the sample size of the first-stage regression (nX), with a strong IV (R2 = 0.025), a sample size for the reduced-form regression (nY) of 10,000, and a confounding variable with equal effects on X and Y (Ξ²UX = Ξ²UY = 0.2). Ξ²XY values are 0.0 (filled diamond), 0.05 (open diamond), 0.1 (filled triangle), 0.15 (open triangle), 0.2 (filled square), and 0.3 (open square).
Power (left) and median standard error (right) of the subsample instrumental-variable (IV) estimate for different values of the first-stage R2 and the sample size of the first-stage regression (nX), with a constant effect size (Ξ²XY = 0.2), a sample size for the reduced-form regression (nY) of 10,000, and a confounding variable with equal effects on X and Y (Ξ²UX = Ξ²UY = 0.2). First-stage R2 values are 0.002 (filled diamond), 0.004 (open diamond), 0.007 (filled triangle), 0.01 (open triangle), 0.0015 (filled square), 0.2 (open square), 0.03 (filled circle), and 0.05 (open circle).
Bias in the subsample instrumental-variable (IV) estimate in confounded (left) and unconfounded (right) scenarios for different values of the average first-stage F statistic and the relative size of the subsample used in the first-stage regression (nX:nY), with a constant causal effect size (Ξ²XY = 0.1) and a confounding variable with equal effects on X and Y (Ξ²UX = Ξ²UY = 0.3). Values for nX:nY are 1 (filled diamond), 0.75 (open diamond), 0.5 (filled triangle), 0.25 (open triangle), and 0.1 (filled square). The sample size for the reduced-form regression equation (nY, on the right vertical axis) is shown as dots connected with a dashed line.
Bias in the subsample instrumental-variable (IV) estimate for different values of the first-stage R2 and the relative size of the sample used in the first-stage regression (nX:nY). The sample size for the reduced-form regression equation (nY) is 10,000 (top), 3,000 (middle), and 1,000 (bottom), with a constant causal effect size (Ξ²XY = 0.1) and a confounding variable with equal effects on X and Y (Ξ²UX = Ξ²UY = 0.3). Values for nX:nY are 1 (filled diamond), 0.75 (open diamond), 0.5 (filled triangle), 0.25 (open triangle), and 0.1 (filled square).
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| Mendelian randomization analysis reveals causal effects of metformin on bipolar disorder risk. | Li Z et al. | β | 2025 | β |
| Mendelian Randomization Analysis Supports a Causal Relationship Between Circulating Inflammatory Proteins and Basal Cell Carcinoma. | Fu ZD et al. | β | 2025 | β |
| Mendelian randomization analysis to identify potential drug targets for osteoarthritis. | Lu C et al. | β | 2025 | β |
| Mendelian randomization analysis unveils causal relationships between skin microbiota and osteomyelitis. | Wang Y et al. | β | 2025 | β |
| Mendelian randomization in SLEEP: avoiding pitfalls with MR-SLEEP guidelines. | Evans DS et al. | β | 2025 | β |
| Mendelian randomization, lipids, and coronary artery disease: trade-offs between study designs and assumptions. | Shi J et al. | β | 2025 | β |
| Mendelian randomization study explores the peripheral immunological characteristics of colorectal cancer. | Yuan C et al. | β | 2025 | β |
| Mendelian randomization study reveals the causal effect of sex hormone binding globulin on osteoporosis. | Zuo GS et al. | β | 2025 | β |
| Metabolic factors, gut microbiota, and cognitive performance: Mendelian randomization analysis. | Yu E et al. | β | 2025 | β |
| Metabolic Insights into Urinary Stone Formation: Evidence from Mendelian Randomization, Clinical, and in vivo Studies. | Miao L et al. | β | 2025 | β |
| Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics. | Wang C et al. | β | 2025 | β |
| MR analysis reveals no causal association between mitochondrial DNA copy number and osteoporosis. | Xiao M et al. | β | 2025 | β |
| MRdb: a comprehensive database of univariate and multivariate Mendelian randomization with large-scale GWAS summary data. | Liu Q et al. | β | 2025 | β |
| Multi-tissue transcriptome-wide association study identifies novel candidate genes and pleiotropy effects across four abdominal hernia subtypes. | Chaar DL et al. | β | 2025 | β |
| MUTATE: a human genetic atlas of multiorgan artificial intelligence endophenotypes using genome-wide association summary statistics. | Boquet-Pujadas A et al. | β | 2025 | β |
| New therapeutic targets and mechanisms of papillary thyroid carcinoma identified by multi-omics analysis. | Xu J et al. | β | 2025 | β |
| Novel causal associations between plasma metabolites and prostate cancer risk revealed by mendelian randomization. | Chen H et al. | β | 2025 | β |
| Periodontitis and the Risk of Heart Failure:a Meta-analysis and Mendelian Randomisation Study. | Chen Y et al. | β | 2025 | β |
| Peripheral Immune Cells Contribute to the Pathogenesis of Alzheimer's Disease. | Zhang H et al. | β | 2025 | β |
| Perspectives on the gut microbiota in patients with non-small cell lung cancer-Two-Sample Mendelian Randomization combined with bibliometric analysis (2001-2023). | Fu XQ et al. | β | 2025 | β |
| Plasma lipidome and intracranial aneurysms: A univariable and multivariable Mendelian randomization study. | Liu X et al. | β | 2025 | β |
| Plasma proteins and coronary atherosclerosis: A Mendelian randomization study. | Pan H et al. | β | 2025 | β |
| Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease. | Ao L et al. | β | 2025 | β |
| Premature ovarian insufficiency as a consequence of immunological abnormalities and dyslipidemia: a Mendelian randomization study. | Shao F et al. | β | 2025 | β |
| Raising the bar for publication of Mendelian randomisation studies in Diabetologia. | Corbin LJ et al. | β | 2025 | β |
| Real-world data and Mendelian randomization analysis in assessing adverse reactions of rilonacept. | Liu L et al. | β | 2025 | β |
| Regular use of pharmaceutical opioids and subsequent risk of cancer: a prospective cohort study and Mendelian randomization analysis. | Sheikh M et al. | β | 2025 | β |
| Relationships among host genetics, gut microbiota, and asthma in US Hispanic/Latino adults. | Stanislawski MA et al. | β | 2025 | β |
| Revealing the genetic architectures underlying organ-specific aging based on proteomic data. | Zhu RJ et al. | β | 2025 | β |
| Revisiting the Relationship between Homocysteine, Vitamin B12, Folate, and Aortic Diseases. | Lang Q et al. | β | 2025 | β |
| Rib and Sternum Fractures From Falls: Global Burden of Disease and Predictions. | Huang Z et al. | β | 2025 | β |
| Sedentary Leisure Behaviour, Physical Activity, and Gastroesophageal Reflux Disease: Evidence From a Mendelian Randomization Analysis. | Lu S et al. | β | 2025 | β |
| Selenoprotein S and the Causal Risk of Hypertension in Pregnancy: A Mendelian Randomization Study. | Cai M et al. | β | 2025 | β |
| Separating the Effects of Adiposity Across Different Life Stages on Human Longevity and Aging. | Xiao P et al. | β | 2025 | β |
| Serum metabolites and risk of sudden sensorineural hearing loss: A Mendelian randomization study. | Yuan W et al. | β | 2025 | β |
| Serum Metabolites as Mediator Between Autoimmune Hyperthyroidism and Epilepsy: A Mendelian Randomization Analysis. | Zhang K et al. | β | 2025 | β |
| Shikonin as a therapeutic agent in renal cell carcinoma: insights from TEK-related causal association with glaucoma. | Jia R et al. | β | 2025 | β |
| Single-Cell Transcriptome-Wide Mendelian Randomization and Colocalization Analyses Uncover Cell-Specific Mechanisms in Epigenetic Age Acceleration. | Hong Y | β | 2025 | β |
| Skin Microbiota and Pathological Scars: A Bidirectional Two-Sample Mendelian Randomization Study. | Huang Y et al. | β | 2025 | β |
| Sleep traits causally affect epigenetic age acceleration: a Mendelian randomization study. | Zhao W et al. | β | 2025 | β |
| Smoking as a causative factor in chronic kidney disease: a two-sample Mendelian randomization study. | Yang Y et al. | β | 2025 | β |
| Smoking may be a risk factor for carpal tunnel syndrome: Insights from Mendelian randomization analysis. | Shi W et al. | β | 2025 | β |
| Spleen volume in relation to ulcerative colitis and Crohn's disease: a Mendelian randomization study. | Su Q et al. | β | 2025 | β |
| Systematic Druggable-Proteome-Wide Mendelian Randomization Identifies Potential Therapeutic Targets for Allergic Conjunctivitis. | Chen J et al. | β | 2025 | β |
| Testosterone and colorectal cancer: a bidirectional Mendelian randomization study. | Li J et al. | β | 2025 | β |
| The association between basal metabolic rate and ischemic stroke: a Mendelian randomization study. | Chen Y et al. | β | 2025 | β |
| The brief resilience scale: a genome-wide association study in the UK Biobank. | Cornelis MC et al. | β | 2025 | β |
| The causal association between insomnia and cognitive decline: A 2-sample, 2-step multivariable Mendelian randomization study. | Wang Z et al. | β | 2025 | β |
| The causal relationship between 179 lipid species and urolithiasis: a bidirectional and multivariable Mendelian randomization study combined with meta-analysis. | Wang X et al. | β | 2025 | β |
| The causal relationship between body mass index and perianal abscess: a Mendelian randomization study. | Wu L et al. | β | 2025 | β |
| The Causal Relationship Between Circulating Metabolites and the Risk of Atopic Dermatitis: A Two-Sample Mendelian Randomization Study. | Chen J et al. | β | 2025 | β |
| The causal relationship between inflammatory bowel disease and primary biliary cholangitis: A bidirectional two-sample Mendelian randomization study. | Chen Z et al. | β | 2025 | β |
| The "double-edged sword" effect of non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of endometriosis (EMS). | Shi Z et al. | β | 2025 | β |
| The gut microbiota, circulating metabolites, immune cells, and pancreatitis risk: Evidence from a bidirectional two-sample Mendelian randomization study and mediation analysis. | Zeng YZ et al. | β | 2025 | β |
| The impact of metabolic syndrome on hepatocellular carcinoma: a mendelian randomization study. | Yuan C et al. | β | 2025 | β |
| The influence of mitochondrial biological function on sudden sensorineural hearing loss: Exploring potential mechanisms and associations through Mendelian randomization analysis. | Chen J et al. | β | 2025 | β |
| The Lung-Brain Axis: Genetic Evidence for Causal Effects of Asthma, Allergic Rhinitis, and Chronic Rhinosinusitis on Brain Structure. | Guo T et al. | β | 2025 | β |
| The mediation of circulating inflammatory proteins in the causal pathway from immune cells to osteoarthritis. | Yuan Y et al. | β | 2025 | β |
| The relationship between COVID-19 and stroke and its risk factors, a Mendelian randomization analysis. | Tang C et al. | β | 2025 | β |
| The relationship between insomnia and multiple gastrointestinal disorders: a Mendelian randomization study. | Yu J et al. | β | 2025 | β |
| Thyroid Function and Brain Structure: Insight from a Mendelian Randomization Study. | Li P et al. | β | 2025 | β |
| Understanding Factors That Cause Benign Paroxysmal Positional Vertigo, MΓ©niΓ¨re Disease, and Vestibular Neuritis: A Two-Sample Mendelian Randomization Study. | Guo T et al. | β | 2025 | β |
| Unraveling the causal nexus of cathepsins and rheumatoid arthritis: Insights from a two-sample Mendelian randomization framework. | Zhang H et al. | β | 2025 | β |
| Unraveling the role of gut microbiota and plasma metabolites in fibromyalgia: Insights from Mendelian randomization and dietary interventions. | Niu M et al. | β | 2025 | β |
| Unravelling behavioural contributions to IBS risk: evidence from univariate and multivariate Mendelian randomisation. | Chu H et al. | β | 2025 | β |
| Unveiling the influence of lipidomes on inflammatory bowel disease: a bidirectional mendelian randomization study. | Lei H et al. | β | 2025 | β |
| Using Mendelian randomization to investigate etiologic heterogeneity across renal cell carcinoma subtypes. | Winter TD et al. | β | 2025 | β |
| What comes first: Heart rate variability changes or insomnia? A causal investigation using Mendelian randomization. | Yan B et al. | β | 2025 | β |
| 25-Hydroxyvitamin D, Vitamin D Binding Protein and Gestational Diabetes Mellitus: A Two-Sample Mendelian Randomization Study. | Qiu Y et al. | β | 2024 | β |
| A Bayesian approach to Mendelian randomization using summary statistics in the univariable and multivariable settings with correlated pleiotropy. | Grant AJ et al. | β | 2024 | β |
| A causal association between chemokines and the risk of lung cancer: a univariate and multivariate mendelian randomization study. | Wang M et al. | β | 2024 | β |
| A causal relationship between gut microbiota and subcortical brain structures contributes to the microbiota-gut-brain axis: a Mendelian randomization study. | Hu X et al. | β | 2024 | β |
| A causal relationship between panic disorder and risk of alzheimer disease: a two-sample mendelian randomization analysis. | Tian Y et al. | β | 2024 | β |
| A causal relationship between particulate matter 2.5 and obesity and its related indicators: a Mendelian randomization study of European ancestry. | Wu TQ et al. | β | 2024 | β |
| A causal relationship between sarcopenia and cognitive impairment: A Mendelian randomization study. | Liu H et al. | β | 2024 | β |
| A genome-wide association study of neutrophil count in individuals associated to an African continental ancestry group facilitates studies of malaria pathogenesis. | Constantinescu AE et al. | β | 2024 | β |
| Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis. | Rontogianni MO et al. | β | 2024 | β |
| A mendelian randomization study investigating the causal relationships between 1400 serum metabolites and autoimmune diseases. | Song S et al. | β | 2024 | β |
| A Mendelian randomization study on the association of bone mineral density with periodontitis. | Yu Y et al. | β | 2024 | β |
| A Modified Debiased Inverse-Variance Weighted Estimator in Two-Sample Summary-Data Mendelian Randomization. | Su Y et al. | β | 2024 | β |
| An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study. | Ren F et al. | β | 2024 | β |
| An integrative multi-context Mendelian randomization method for identifying risk genes across human tissues. | Lu Y et al. | β | 2024 | β |
| Ankylosing spondylitis status and risk of secondary systemic amyloidosis: A two-sample mendelian randomization study. | Chen H et al. | β | 2024 | β |
| Assessing the association between tea intake and risk of dental caries and periodontitis: a two-sample Mendelian randomization study. | Jin B et al. | β | 2024 | β |
| Assessing the causal association between sleep apnea and the human gut microbiome composition: A two-sample Mendelian randomization study. | Yu M et al. | β | 2024 | β |
| Association between 19 medication use and risk of common cancers: A cross-sectional and Mendelian randomisation study. | Yun Z et al. | β | 2024 | β |
| Association between body fat distribution and age at menarche: a two sample Mendelian randomization study. | Xue P et al. | β | 2024 | β |
| Association between Body Mass Index and Early Renal Function after Kidney Transplantation: Observational and Mendelian Randomization Study. | Ming S et al. | β | 2024 | β |
| Association between Branched-Chain amino acids and Epilepsy: A Mendelian randomized study. | Zhang C et al. | β | 2024 | β |
| Association between dementia, Alzheimer's disease, and liver cancer: A Mendelian randomization analysis. | Li T et al. | β | 2024 | β |
| Association between dietary tea consumption and non-alcoholic fatty liver disease: a study based on Mendelian randomisation and National Health and Nutrition Examination Survey (2005-2018) association between tea and non-alcoholic fatty liver disease. | Liu S et al. | β | 2024 | β |
| Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study. | Ye C et al. | β | 2024 | β |
| Association between iron status, preeclampsia and gestational hypertension: A bidirectional two-sample Mendelian randomization study. | Li P et al. | β | 2024 | β |
| Association between irritable bowel syndrome and Parkinson's disease by Cohort study and Mendelian randomization analysis. | Wang ZY et al. | β | 2024 | β |
| Association between prescription opioid use and heart failure: Cohort studies and Mendelian randomization analysis. | Hao G et al. | β | 2024 | β |
| Association Between Rheumatoid Arthritis and Clonal Hematopoiesis: A Mendelian Randomization Study. | Zhang J et al. | β | 2024 | β |
| Association between sugar-sweetened beverages and pure fruit juice with risk of six cardiovascular diseases: a Mendelian randomization study. | Xie H et al. | β | 2024 | β |
| Association between telomere length and idiopathic normal pressure hydrocephalus: a Mendelian randomization study. | Yang F et al. | β | 2024 | β |
| Association between venous thromboembolism and atrial fibrillation: a Mendelian randomization study. | Dang C et al. | β | 2024 | β |
| Association of asthma and lung cancer risk: A pool of cohort studies and Mendelian randomization analysis. | Huang Q et al. | β | 2024 | β |
| Association of inflammatory cytokines with type 2 diabetes mellitus and diabetic nephropathy: a bidirectional Mendelian randomization study. | Song S et al. | β | 2024 | β |
| Association of major depressive disorder and increased risk of irritable bowel syndrome: A population-based cohort study and a two-sample Mendelian randomization study in the UK biobank. | Wang W et al. | β | 2024 | β |
| Association of mental disorders with sepsis: a bidirectional Mendelian randomization study. | Hu Y et al. | β | 2024 | β |
| Association of serum uric acid with male sexual hormones and erectile dysfunction: a bidirectional 2-sample Mendelian randomization analysis. | Chen H et al. | β | 2024 | β |
| Association of socioeconomic position with sensory impairment among Chinese population: a nationally representative cohort and Mendelian randomization study. | Wei J et al. | β | 2024 | β |
| Associations between artificial sweetener intake from cereals, coffee, and tea and the risk of type 2 diabetes mellitus: A genetic correlation, mediation, and mendelian randomization analysis. | Zhang Y et al. | β | 2024 | β |
| Associations between benign paroxysmal positional vertigo and seven mental disorders: a two-sample Mendelian randomization study. | Liu S et al. | β | 2024 | β |
| Associations between genetically determined dietary factors and risk of autism spectrum disorder: a Mendelian randomization study. | Li W et al. | β | 2024 | β |
| Associations between gut microbiota and chronic sinusitis: A bidirectional Mendelian randomization study. | Pu K et al. | β | 2024 | β |
| Associations between immune cell phenotypes and lung cancer subtypes: insights from mendelian randomization analysis. | Zheng JM et al. | β | 2024 | β |
| Associations between type 1 diabetes and pulmonary tuberculosis: a bidirectional mendelian randomization study. | Jiang Y et al. | β | 2024 | β |
| Associations of 50 modifiable risk factors with atrial fibrillation using Mendelian randomization analysis. | Zhang Z et al. | β | 2024 | β |
| Associations of genetically predicted iron status with 24 gastrointestinal diseases and gut microbiota: a Mendelian randomization study. | Su T et al. | β | 2024 | β |
| A systematic two-sample and bidirectional MR process highlights a unidirectional genetic causal effect of allergic diseases on COVID-19 infection/severity. | Chen XT et al. | β | 2024 | β |
| A two-sample bidirectional Mendelian randomization analysis investigates associations between gut microbiota and type 2 diabetes mellitus. | Song S et al. | β | 2024 | β |
| A two-sample mendelian randomization study of non-tuberculous mycobacteria infection and lung cancer. | Shen H et al. | β | 2024 | β |
| Autoimmune diseases and cardiovascular risk: Mendelian randomization analysis for the impact of 19 autoimmune diseases on 14 cardiovascular conditions. | Bao Y et al. | β | 2024 | β |
| Autoimmune thyroid disease and myasthenia gravis: a study bidirectional Mendelian randomization. | Wang S et al. | β | 2024 | β |
| Basal metabolic rate mediates the causal relationship between gut microbiota and osteoarthritis: a two-step bidirectional Mendelian randomization study. | Li J et al. | β | 2024 | β |
| Bidirectional two-sample Mendelian randomization analysis unveils causal association between inflammatory cytokines and the risk of diabetic nephropathy. | Song S et al. | β | 2024 | β |
| Body Mass Index and Risk of Female Reproductive System Tumors Subtypes: A Meta-Analysis Using Mendelian Randomization. | Jiang XY et al. | β | 2024 | β |
| Borderline personality disorder and risk of atrial fibrillation: insights from a bidirectional Mendelian randomization study. | Zhou W et al. | β | 2024 | β |
| Brain imaging traits and epilepsy: Unraveling causal links via mendelian randomization. | Li F et al. | β | 2024 | β |
| Breast cancer and neoplasms of the thyroid gland: a bidirectional two-sample Mendelian randomization study. | Sun Y et al. | β | 2024 | β |
| Causal association between asthma and periodontitis: A two-sample Mendelian randomization analysis. | Jiao R et al. | β | 2024 | β |
| Causal association between blood metabolites and abdominal aortic calcification: A bidirectional Mendelian randomization study. | Yang H et al. | β | 2024 | β |
| Causal association between circulating inflammatory cytokines and intracranial aneurysm and subarachnoid hemorrhage. | He Q et al. | β | 2024 | β |
| Causal association between dried fruit intake and risk of osteoarthritis: A Mendelian randomization study. | Liang R et al. | β | 2024 | β |
| Causal association between psoriasis vulgaris and bullous pemphigoid: a two-sample bidirectional Mendelian randomization study. | Zhang A et al. | β | 2024 | β |
| Causal association between tea consumption and head and neck cancer: a Mendelian randomization study. | Zhang QH et al. | β | 2024 | β |
| Causal association of circulating immune cells and lymphoma: A Mendelian randomization study. | Wang F et al. | β | 2024 | β |
| Causal association of dietary factors with five common cancers: univariate and multivariate Mendelian randomization studies. | Yang L et al. | β | 2024 | β |
| Causal Association of Iron Status With Functional Outcome After Ischemic Stroke. | He Q et al. | β | 2024 | β |
| Causal association of leisure sedentary behavior and cervical spondylosis, sciatica, intervertebral disk disorders, and low back pain: a Mendelian randomization study. | Qiu Y et al. | β | 2024 | β |
| Causal association of metabolic syndrome with chronic kidney disease progression: A Mendelian randomization study. | Guo Q et al. | β | 2024 | β |
| Causal association of smoking, blood lipids, and bladder cancer: Insights from a multivariable and mediation mendelian randomization investigation. | Wei H et al. | β | 2024 | β |
| Causal associations between chronic viral hepatitis and psychiatric disorders: a Mendelian randomization study. | Fu H et al. | β | 2024 | β |
| Causal associations between gut microbiota, metabolites and asthma: a two-sample Mendelian randomization study. | Li J et al. | β | 2024 | β |
| Causal associations between psoriasis, eczema, urticaria, and mental illness: A bidirectional Mendelian randomization study of the European population. | Mo N et al. | β | 2024 | β |
| Causal associations between sleep traits and age at natural menopause: A Mendelian randomization study. | Gan X et al. | β | 2024 | β |
| Causal associations of genetically predicted gut microbiota and blood metabolites with inflammatory states and risk of infections: a Mendelian randomization analysis. | Liu Y et al. | β | 2024 | β |
| Causal associations of white blood cell count and sudden sensorineural hearing loss: a bidirectional and multivariable Mendelian randomization study. | Zhang L et al. | β | 2024 | β |
| Causal Effect of Atrial Fibrillation on Heart Failure Risk in East Asian Ancestry: AΒ Bidirectional Mendelian Randomization Study Using Genome-wide Association Data. | Mei Y et al. | β | 2024 | β |
| Causal effect of gut microbiota on the risk of prostatitis: a two-sample Mendelian randomization study. | Liu D et al. | β | 2024 | β |
| Causal effect of immune cells on idiopathic pulmonary fibrosis: A mendelian randomization study. | Li X et al. | β | 2024 | β |
| Causal effect of interleukin (IL)-6 on blood pressure and hypertension: A mendelian randomization study. | Wu O et al. | β | 2024 | β |
| Causal effects of lipid-lowering drugs on inflammatory skin diseases: Evidence from drug target Mendelian randomisation. | Zang C et al. | β | 2024 | β |
| Causal effects of PM<sub>2.5</sub> exposure on neuropsychiatric disorders and the mediation via gut microbiota: A Mendelian randomization study. | Li C et al. | β | 2024 | β |
| Causal effects of sepsis on structural changes in cerebral cortex: A Mendelian randomization investigation. | Zhou D et al. | β | 2024 | β |
| Causal effects of specific gut microbiota on spinal stenosis diseases: a two-sample mendelian randomization study. | Luo K et al. | β | 2024 | β |
| Causality between neuroticism personality clusters and female reproductive diseases in European population: a two-sample bidirectional mendelian randomization study. | Kong X et al. | β | 2024 | β |
| Causality investigation among gut microbiota, immune cells, and prostate diseases: a Mendelian randomization study. | Yue SY et al. | β | 2024 | β |
| Causality of blood metabolites and metabolic pathways on Graves' disease and Graves' ophthalmopathy: a two-sample Mendelian randomization study. | Wang T et al. | β | 2024 | β |
| Causality of blood metabolites and metabolic pathways on peripheral arteriosclerosis: a Mendelian randomization study. | Ye Q et al. | β | 2024 | β |
| Causality of genetically determined blood metabolites on irritable bowel syndrome: A Mendelian randomization study. | Dai X et al. | β | 2024 | β |
| Causality of Genetically Determined Metabolites on Chronic Kidney Disease: A Two-Sample Mendelian Randomization Study <i>In Silico</i>. | Zhang Z et al. | β | 2024 | β |
| Causality of genetically determined metabolites on susceptibility to prevalent urological cancers: a two-sample Mendelian randomization study and meta-analysis. | Dai X et al. | β | 2024 | β |
| Causality of metabolites and metabolic pathways on cholestatic liver diseases: a Mendelian randomization study. | Wei Z et al. | β | 2024 | β |
| Causal links between serum micronutrients and epilepsy: a Mendelian randomization analysis. | Chen H et al. | β | 2024 | β |
| Causal relationship between 731 immune cells and the risk of diabetic nephropathy: a twoβsample bidirectional Mendelian randomization study. | Song S et al. | β | 2024 | β |
| Causal Relationship between Aging and Anorexia Nervosa: A White-Matter-Microstructure-Mediated Mendelian Randomization Analysis. | Qiu H et al. | β | 2024 | β |
| Causal relationship between dementia and delirium: Insights from a bidirectional two-sample Mendelian randomization analysis. | Cai Y et al. | β | 2024 | β |
| Causal relationship between diabetes mellitus, glycemic traits and Parkinson's disease: a multivariable mendelian randomization analysis. | Wang Q et al. | β | 2024 | β |
| Causal relationship between diet and knee osteoarthritis: A Mendelian randomization analysis. | Lv X et al. | β | 2024 | β |
| Causal relationship between dietary intake and IgA nephropathy: a Mendelian randomization study. | Li Y et al. | β | 2024 | β |
| Causal relationship between endometrial cancer and risk of breast cancer: A 2-sample Mendelian randomization study. | Liu Y et al. | β | 2024 | β |
| Causal relationship between folic acid and prostate cancer risk: Insights from Mendelian randomization analysis. | Guo X et al. | β | 2024 | β |
| Causal Relationship Between Gastroesophageal Reflux Disease and the Risk of Chronic Rhinosinusitis: Insights from Multivariable and Mediation Mendelian Randomization Analysis. | Wu C et al. | β | 2024 | β |
| Causal relationship between gut microbiota and diabetic complications: a two-sample Mendelian randomization study. | Liu J et al. | β | 2024 | β |
| Causal relationship between gut microbiota and tuberculosis: a bidirectional two-sample Mendelian randomization analysis. | Yuan Z et al. | β | 2024 | β |
| Causal relationship between gut microbiota, plasma metabolites, inflammatory cytokines and abdominal aortic aneurysm: a Mendelian randomization study. | Li C et al. | β | 2024 | β |
| Causal relationship between human blood metabolites and risk of ischemic stroke: a Mendelian randomization study. | He M et al. | β | 2024 | β |
| Causal relationship between hyperthyroidism and cataracts: a two-sample bi-directional mendelian randomization study. | Ding H et al. | β | 2024 | β |
| Causal relationship between immune cells and epilepsy mediated by metabolites analyzed through Mendelian randomization. | Chen J et al. | β | 2024 | β |
| Causal relationship between inflammatory skin diseases and immunoglobulin A nephropathy: A Mendelian randomization and enrichment analysis study. | Li C et al. | β | 2024 | β |
| Causal relationship between lactate dehydrogenase and risk of developing ischemic stroke: A Mendelian randomized study. | Dong F et al. | β | 2024 | β |
| Causal relationship between leukocyte telomere length and two cardiomyopathies based on a bidirectional Mendelian randomization approach. | Li J et al. | β | 2024 | β |
| Causal relationship of genetically predicted gut microbiota with thyroid cancer: a bidirectional two-sample mendelian randomization study. | Sun X et al. | β | 2024 | β |
| Causal Relationship of Skin Microbiota on Psoriasis: A Mendelian Randomization Study. | Chen Y et al. | β | 2024 | β |
| Causal relationships between Alzheimer's disease and metabolic dysfunction associated with fatty liver disease: insights from bidirectional network Mendelian Randomization analysis. | Liu L et al. | β | 2024 | β |
| Causal relationships between blood metabolites and diabetic retinopathy: a two-sample Mendelian randomization study. | Yang C et al. | β | 2024 | β |
| Causal relationships between epilepsy and the microstructure of the white matter: A Mendelian randomization study. | Xie Z et al. | β | 2024 | β |
| Causal relationships between gut microbiome and obstructive sleep apnea: a bi-directional Mendelian randomization. | Liu L et al. | β | 2024 | β |
| Causal Relationships between Lymphocyte Subsets and Risk of Coronary Artery Disease: A Two-Sample Mendelian Randomization Study. | Ma Z et al. | β | 2024 | β |
| Causal relationships between obesity-related anthropometric indicators and sepsis risk: a Mendelian-randomization study. | Zhang C et al. | β | 2024 | β |
| Causal relationships between rheumatoid arthritis and neurodegenerative diseases: a two-sample univariable and multivariable Mendelian randomization study. | Chen X et al. | β | 2024 | β |
| Causal relationships exist between polycystic ovary syndrome and adverse pregnancy and perinatal outcomes: a Mendelian randomization study. | Ma Y et al. | β | 2024 | β |
| Circulating micronutrient levels and respiratory infection susceptibility and severity: a bidirectional Mendelian randomization analysis. | Wei Z et al. | β | 2024 | β |
| Circulating micronutrient levels and their association with sepsis susceptibility and severity: a Mendelian randomization study. | Wei Z et al. | β | 2024 | β |
| Deciphering proteins in Alzheimer's disease: A new Mendelian randomization method integrated with AlphaFold3 for 3D structure prediction. | Yao M et al. | β | 2024 | β |
| Decreased circulating omega-3 fatty acids increase the risk of myocardial infarction: a two-sample Mendelian randomization study. | Wang W et al. | β | 2024 | β |
| DHEA and response to antidepressant treatment: A Mendelian Randomization analysis. | Souza-Teodoro LH et al. | β | 2024 | β |
| Diastolic and systolic blood pressure and gout: a Mendelian randomization study. | Li Y et al. | β | 2024 | β |
| Dietary patterns and diabetic microvascular complications risk: a Mendelian randomization study of European ancestry. | Zhou X et al. | β | 2024 | β |
| Discovery and Exploration of Lipid-Modifying Drug Targets for ALS by Mendelian Randomization. | Jiang Z et al. | β | 2024 | β |
| Dissecting causal relationships between immune cells, plasma metabolites, and COPD: a mediating Mendelian randomization study. | Cao Z et al. | β | 2024 | β |
| Dissecting the causal role of immunophenotypes in primary sclerosing cholangitis risk: A Mendelian randomization study. | Zhou J et al. | β | 2024 | β |
| Dissecting the shared genetic landscape of anxiety, depression, and schizophrenia. | Tao Y et al. | β | 2024 | β |
| Dual effects of serum urate on stroke risk and prognosis: insights from Mendelian randomization. | Chen S et al. | β | 2024 | β |
| Educational attainment, income, and attention deficit hyperactivity disorder: A mediation analysis based on two-step Mendelian randomization. | Xie T et al. | β | 2024 | β |
| Effect of the gut microbiome, plasma metabolome, peripheral cells, and inflammatory cytokines on obesity: a bidirectional two-sample Mendelian randomization study and mediation analysis. | Li Y et al. | β | 2024 | β |
| Elevated serum LDL-C increases the risk of Lewy body dementia: a two-sample mendelian randomization study. | Liu P et al. | β | 2024 | β |
| Eligibility for knee arthroplasty is associated with increased risk of acquired hallux valgus - a Mendelian randomized study. | Li Z et al. | β | 2024 | β |
| Elucidating the causal relationship between 486 genetically predicted blood metabolites and the risk of gastric cancer: a comprehensive Mendelian randomization analysis. | Qian L et al. | β | 2024 | β |
| Elucidating the causal relationship between gut microbiota, metabolites, and diabetic nephropathy in European patients: Revelations from genome-wide bidirectional mendelian randomization analysis. | Song S et al. | β | 2024 | β |
| Epilepsy and psychiatric comorbidities: A bidirectional mendelian randomization study. | Chu H et al. | β | 2024 | β |
| Evaluating the link between immune characteristics and attention deficit hyperactivity disorder through a bi-directional Mendelian randomization study. | Jue H et al. | β | 2024 | β |
| Evaluating the relationship between standing height, body mass index, body fat percentage with risk of inguinal hernia: a Mendelian randomization study. | Li Y et al. | β | 2024 | β |
| Evaluation of the causal effects of blood metabolites on irritable bowel syndrome: Mendelian randomization. | Zeng Y et al. | β | 2024 | β |
| Evidence for no genetic causal association between skin response to sun exposure and systemic lupus erythematosus: A Mendelian randomization study in Europeans and East Asians. | Yang F et al. | β | 2024 | β |
| Evidence of a Causal Relationship Between Body Mass Index and Immune-Mediated and Inflammatory Skin Diseases and Biomarkers: A Mendelian Randomization Study. | Li Z et al. | β | 2024 | β |
| Exploring and validating the necroptotic gene regulation and related lncRNA mechanisms in colon adenocarcinoma based on multi-dimensional data. | Wang W et al. | β | 2024 | β |
| Exploring causal correlations between systemic inflammatory cytokines and epilepsy: A bidirectional Mendelian randomization study. | Sun H et al. | β | 2024 | β |
| Exploring causality between bone mineral density and frailty: A bidirectional Mendelian randomization study. | Shen JX et al. | β | 2024 | β |
| Exploring the causal association between genetically determined circulating metabolome and hemorrhagic stroke. | Wang Y et al. | β | 2024 | β |
| Exploring the causal association of rheumatoid arthritis with atrial fibrillation: a Mendelian randomization study. | Rong JC et al. | β | 2024 | β |
| Exploring the causal links between cigarette smoking, alcohol consumption, and aneurysmal subarachnoid hemorrhage: a two-sample Mendelian randomization analysis. | Lin H et al. | β | 2024 | β |
| Exploring the causal relationship between female reproductive traits and frailty: a two-sample mendelian randomization study. | Fan M et al. | β | 2024 | β |
| Exploring the Causal Relationship between Ibuprofen Use and Osteoarthritis Risk: A Mendelian Randomization Study. | Jian Y et al. | β | 2024 | β |
| Exploring the causal relationship between immune cell and all-cause heart failure: a Mendelian randomization study. | Li J et al. | β | 2024 | β |
| Exploring the causal relationship between immune cells and idiopathic pulmonary fibrosis: a bi-directional Mendelian randomization study. | He Z et al. | β | 2024 | β |
| Exploring the effect of lifestyle behaviors and socioeconomic status on atrial fibrillation: the mediating role of 91 inflammatory cytokines. | Liu Y et al. | β | 2024 | β |
| Exploring the role of gut microbiota in migraine risk: a two-sample Mendelian randomization study. | Meng X et al. | β | 2024 | β |
| Expression quantitative trait locus mapping of extracellular microRNAs in human plasma. | Huan T et al. | β | 2024 | β |
| Gastroesophageal reflux disease and non-alcoholic fatty liver disease: a two-sample Mendelian randomization combined with meta-analysis. | Leng X et al. | β | 2024 | β |
| Genetically Determined Plasma Hepatocyte Growth Factor Levels Are Associated With the Risk and Prognosis of Ischemic Stroke. | Xu Q et al. | β | 2024 | β |
| Genetically predicted 486 blood metabolites in relation to risk of esophageal cancer: a Mendelian randomization study. | Jia C et al. | β | 2024 | β |
| Genetically predicted allergic rhinitis causally increases the risk of erectile dysfunction. | Li P et al. | β | 2024 | β |
| Genetically predicted biomarkers of iron homeostasis and risk of non-ischemic cardiomyopathy: A mendelian randomization study. | Huang H et al. | β | 2024 | β |
| Genetically predicted circulating linoleic acid levels and risk of osteoarthritis: a two-sample mendelian randomization study. | Yang W et al. | β | 2024 | β |
| Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization study. | Wang Z et al. | β | 2024 | β |
| Genetic association between autoimmune thyroiditis and microscopic polyangiitis: A two-sample Mendelian randomization study. | Chen Z et al. | β | 2024 | β |
| Genetic association between mitochondrial DNA copy number and glioma risk: insights from causality. | He Q et al. | β | 2024 | β |
| Genetic causality and metabolite pathway identifying the relationship of blood metabolites and psoriasis. | Wang Z et al. | β | 2024 | β |
| Genetic causality of lipidomic and immune cell profiles in ischemic stroke. | Chen H et al. | β | 2024 | β |
| Genetic correlation and causal relationship between sleep and myopia: a mendelian randomization study. | Zhu G et al. | β | 2024 | β |
| Genetic effect of basal metabolic rate on the benign neoplasm of bone and articular cartilage: a Mendelian randomization study. | Huang G et al. | β | 2024 | β |
| Genetic effect of thyroid function-related diseases on acute respiratory distress syndrome: a Mendelian randomization study. | Li P et al. | β | 2024 | β |
| Genetic evidence reveals a causal relationship between rheumatoid arthritis and interstitial lung disease. | Zhao R et al. | β | 2024 | β |
| Genetic information supports a causal relationship between trace elements, inflammatory proteins, and COPD: evidence from a Mendelian randomization analysis. | Cao Z et al. | β | 2024 | β |
| Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study. | Fan M et al. | β | 2024 | β |
| Genetic insights of blood lipid metabolites on polycystic ovary syndrome risk: a bidirectional two-sample Mendelian randomization study. | Wang X et al. | β | 2024 | β |
| Genetic prediction of micronutrient levels and the risk of colorectal polyps: A mendelian randomization study. | Lv S et al. | β | 2024 | β |
| Genetic support of causal association between lipid and glucose metabolism and stress urinary incontinence in women: a bidirectional Mendelian randomization and multivariable-adjusted study. | Xiang N et al. | β | 2024 | β |
| Genome-wide association studies and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer. | Laskar RS et al. | β | 2024 | β |
| Gut <i>Subdoligranulum variabile</i> ameliorates rheumatoid arthritis by promoting TSG-6 synthesis from joint cells. | Li H et al. | β | 2024 | β |
| Gut microbiota and autoimmune diseases: Insights from Mendelian randomization. | Mu F et al. | β | 2024 | β |
| Gut microbiota and risk of coronary heart disease: a two-sample Mendelian randomization study. | Hu XZ et al. | β | 2024 | β |
| Gut microbiota and sepsis and sepsis-related death: a Mendelian randomization investigation. | Shang W et al. | β | 2024 | β |
| Gut microbiota causally affects drug-induced liver injury via plasma metabolites: a Mendelian randomization study. | Fu H et al. | β | 2024 | β |
| Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study. | Ji D et al. | β | 2024 | β |
| Human blood metabolites and gastric cancer: a Mendelian randomization analysis. | Zhang C et al. | β | 2024 | β |
| Hypertensive disorders of pregnancy and stroke: a univariate and multivariate Mendelian randomization study. | Qu K et al. | β | 2024 | β |
| Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome. | Si S et al. | β | 2024 | β |
| Identifying Proteins and Amino Acids Associated with Liver Cancer Risk: A Study Utilizing Mendelian Randomization and Bulk RNA Sequencing Analysis. | Ma C et al. | β | 2024 | β |
| Immune cells mediate the causal pathway linking circulating complements to cancer: A Mendelian randomization study. | Pan H et al. | β | 2024 | β |
| Impact of insomnia upon inflammatory digestive diseases and biomarkers: a two-sample mendelian randomization research on Europeans. | Dai L et al. | β | 2024 | β |
| Inferring the genetic effects of serum homocysteine and vitamin B levels on autism spectral disorder through Mendelian randomization. | Jin T et al. | β | 2024 | β |
| Inflammatory Bowel Disease and Skin Cancer: A Two-Sample Mendelian Randomization Analysis. | Li A et al. | β | 2024 | β |
| Inflammo-immune perspective on the association of eight migraine risk factors with migraine: a multi-omics Mendelian randomization study. | Zhao J et al. | β | 2024 | β |
| Investigating the association between blood metabolites and telomere length: A mendelian randomization study. | Gao C | β | 2024 | β |
| Investigating the causal association between serum uric acid levels and gastric cancer risk: a Mendelian randomization study. | Zhao X et al. | β | 2024 | β |
| Investigating the Causal Link between Rheumatoid Arthritis and Atrial Fibrillation in East Asian Populations: A Mendelian Randomization Approach. | Luo W et al. | β | 2024 | β |
| Investigation of causal effects of blood metabolites on insomnia and circadian rhythm sleep wake disorders. | Lv Z et al. | β | 2024 | β |
| Iron Status, Thyroid Dysfunction, and Iron Deficiency Anemia: A Two-Sample Mendelian Randomization Study. | Huang X et al. | β | 2024 | β |
| Maternal periodontitis may cause lower birth weight in children: genetic evidence from a comprehensive Mendelian randomization study on periodontitis and pregnancy. | Chen X et al. | β | 2024 | β |
| Mendelian randomization analysis does not reveal a causal association between migraine and Meniere's disease. | Zhang K et al. | β | 2024 | β |
| Mendelian randomization analysis identified serum palmitoylcarnitine as a biomarker for hepatocellular carcinoma | Wang Y | β | 2024 | β |
| Mendelian randomization analysis reveals causal effects of inflammatory bowel disease and autoimmune hyperthyroidism on diffuse large B-cell lymphoma risk. | Lyu C et al. | β | 2024 | β |
| Mendelian randomization analysis using multiple biomarkers of an underlying common exposure. | Jin J et al. | β | 2024 | β |
| Mendelian randomization and transcriptome analysis identified immune-related biomarkers for osteoarthritis. | Pang WW et al. | β | 2024 | β |
| Mendelian Randomization Highlights Gut Microbiota of Short-chain Fatty Acids' Producer as Protective Factor of Cerebrovascular Disease. | Luo S et al. | β | 2024 | β |
| Mendelian randomization of chronic hepatitis B and cardiovascular disease. | Wu D et al. | β | 2024 | β |
| Mendelian randomization provides causal association between COVID-19 and thyroid cancer: insights from a multi-cancer analysis. | Li S et al. | β | 2024 | β |
| Mendelian randomization reveals apolipoprotein B shortens healthspan and possibly increases risk for Alzheimer's disease. | Martin L et al. | β | 2024 | β |
| Mendelian randomization studies of periodontitis: Understanding benefits and natural limitations in an applied context. | Haworth S et al. | β | 2024 | β |
| Mendelian randomization study on association between grip strength and BMD in different age groups. | Zhu Y et al. | β | 2024 | β |
| Mendelian randomization study on insulin resistance and risk of hypertension and cardiovascular disease. | Zhang F et al. | β | 2024 | β |
| Mendelian randomization study reveals a causal relationship between body mass index in children and risk of autoimmune diseases. | He J et al. | β | 2024 | β |
| Mendelian randomization with incomplete measurements on the exposure in the Hispanic Community Health Study/Study of Latinos. | Li Y et al. | β | 2024 | β |
| Metabolome-Wide Mendelian Randomization Assessing the Causal Role of Serum and Cerebrospinal Metabolites in Traumatic Brain Injury. | Duan A et al. | β | 2024 | β |
| MIMOSA: a resource consisting of improved methylome prediction models increases power to identify DNA methylation-phenotype associations. | Melton HJ et al. | β | 2024 | β |
| Modifiable risk factors mediate the effect of gastroesophageal reflux disease on stroke and subtypes: A Mendelian randomization study. | Chen S et al. | β | 2024 | β |
| Multiome-wide Association Studies: Novel Approaches for Understanding Diseases. | Shao M et al. | β | 2024 | β |
| Navigating Mendelian Randomization in Sleep Medicine: Challenges, Opportunities, and Best Practices. | BaHammam AS et al. | β | 2024 | β |
| No causal relationship between serum vitamin D levels and alcoholic liver disease: a two-sample bidirectional Mendelian randomization study. | Wu H et al. | β | 2024 | β |
| No Evidence of Causal Association Between Atopic Dermatitis and Primary Open-Angle Glaucoma: A Bidirectional Two-Sample Mendelian Randomization Study. | Luan X et al. | β | 2024 | β |
| No genetic association between iron deficiency anemia and ischemic stroke and its subtypes: a bidirectional two-sample Mendelian randomization study. | Chen X et al. | β | 2024 | β |
| Obesity-related indicators and tuberculosis: A Mendelian randomization study. | Cai N et al. | β | 2024 | β |
| Observational and genetic evidence disagree on the association between loneliness and risk of multiple diseases. | Liang YY et al. | β | 2024 | β |
| Pathogenic Factor Analysis of Shoulder Periarthritis and Design of Virtual Reality Exercise Intervention System. | Tian Y et al. | β | 2024 | β |
| Physical activity and the osteoarthritis of the knee: A Mendelian randomization study. | Ma X et al. | β | 2024 | β |
| Plasma fatty acids and attention deficit hyperactivity disorder: a Mendelian randomization investigation. | Zhou K et al. | β | 2024 | β |
| Plasma metabolites and risk of seven cancers: a two-sample Mendelian randomization study among European descendants. | Chen Y et al. | β | 2024 | β |
| Potential causal association between gut microbiome and posttraumatic stress disorder. | He Q et al. | β | 2024 | β |
| Potential of gut microbiota metabolites in treating COPD: network pharmacology and Mendelian randomization approaches. | Cao Z et al. | β | 2024 | β |
| PTGES2 and RNASET2 identified as novel potential biomarkers and therapeutic targets for basal cell carcinoma: insights from proteome-wide mendelian randomization, colocalization, and MR-PheWAS analyses. | Han QJ et al. | β | 2024 | β |
| PYPE: A pipeline for phenome-wide association and Mendelian randomization in investigator-driven biobank scale analysis. | Dalal T et al. | β | 2024 | β |
| Relationship between type 1 diabetes and autoimmune diseases in european populations: A two-sample Mendelian randomization study. | Xie W et al. | β | 2024 | β |
| Role of CD38 in mediating the effect of Bacillus on acute pancreatitis: a study of mediated Mendelian randomization. | Xiao J et al. | β | 2024 | β |
| Sex hormones and risk of lung and colorectal cancers in women: a Mendelian randomization study. | Denos M et al. | β | 2024 | β |
| Shared genetic architecture between periodontal disease and type 2 diabetes: a large scale genome-wide cross-trait analysis. | Wu KCH et al. | β | 2024 | β |
| Smoking as a mediator in the association between major depressive disorder and schizophrenia on lung cancer risk: a bidirectional/multivariable and mediation Mendelian randomization study. | Zhu X et al. | β | 2024 | β |
| SUMMIT-FA: a new resource for improved transcriptome imputation using functional annotations. | Melton HJ et al. | β | 2024 | β |
| Systemic inflammatory regulators and preeclampsia: a two-sample bidirectional Mendelian randomization study. | Li C et al. | β | 2024 | β |
| The association between lipid biomarkers and osteoarthritis based on the National Health and Nutrition Examination Survey and Mendelian randomization study. | Huang G et al. | β | 2024 | β |
| The association between primary frozen shoulder and serum lipids may be overestimated: evidence based on retrospective observational studies and Mendelian randomization. | Zhang Y et al. | β | 2024 | β |
| The association between tea consumption and non-malignant digestive system diseases: A Mendelian randomized study. | Sun Q et al. | β | 2024 | β |
| The associations between modifiable risk factors and constipation: a comprehensive mendelian randomization study. | Chang H et al. | β | 2024 | β |
| The causal effects of age at menarche and age at menopause on sepsis: A two-sample Mendelian randomization analysis. | Guo N et al. | β | 2024 | β |
| The causal effects of atopic dermatitis on the risk of skin cancers: A two-sample Mendelian randomization study. | Luo M et al. | β | 2024 | β |
| The causality between systemic inflammatory regulators and chronic respiratory diseases: A bidirectional Mendelian-randomization study. | Jiang G et al. | β | 2024 | β |
| The causal nexus between diverse smoking statuses, potential therapeutic targets, and NSCLC: insights from Mendelian randomization and mediation analysis. | Cao Z et al. | β | 2024 | β |
| The causal relationship between cholecystectomy and IBD/IBS and the role of bile acids and gut microbiota: a two-sample Mendelian randomization study. | Peng D et al. | β | 2024 | β |
| The causal relationship between gut microbiota and diabetic neuropathy: a bi-directional two-sample Mendelian randomization study. | Xie L et al. | β | 2024 | β |
| The causal relationship between human blood metabolites and risk of peripheral artery disease: a Mendelian randomization study. | Dong Z et al. | β | 2024 | β |
| The causal relationship between rheumatoid arthritis and bronchiectasis: a bidirectional Mendelian randomization study. | Li Y et al. | β | 2024 | β |
| The causal relationship between sarcopenia-related traits and ECG indices - A mendelian randomization study. | Fu C et al. | β | 2024 | β |
| The genetic causal effect of hand grip strength on osteoporosis and falling risk: a Mendelian randomization study. | Ma Y et al. | β | 2024 | β |
| The genetic effects of hormones modulated by the Pituitary-Thyroid/Adrenal/Gonadal axis on the risk of developing venous thromboembolism: a mendelian randomization study. | Tian H et al. | β | 2024 | β |
| The integrity of the corticospinal tract and corpus callosum, and the risk of ALS: univariable and multivariable Mendelian randomization. | Wu J et al. | β | 2024 | β |
| The plasma lipids with different fatty acid chains are associated with the risk of hemorrhagic stroke: a Mendelian randomization study. | Zhang X et al. | β | 2024 | β |
| The protective role of water intake in age-related eye diseases: insights from a Mendelian randomization study. | Mi Y et al. | β | 2024 | β |
| The relationship between autoimmune disorders and intracranial aneurysms in East Asian and European populations: a bidirectional and multivariable two-sample Mendelian randomization study. | Tang C et al. | β | 2024 | β |
| The relationship between human blood metabolites and preeclampsia-eclampsia: A Mendelian randomization study. | Wei J et al. | β | 2024 | β |
| The relationship between inflammatory factors and heart failure: evidence based on bidirectional Mendelian randomization analysis. | Huang X et al. | β | 2024 | β |
| The relationship between metabolites and gout: a Mendelian randomization study. | Ding Z et al. | β | 2024 | β |
| The Relationship Between PM2.5 and Eight Common Lung Diseases: A Two-Sample Mendelian Randomization Analysis. | Jiang Y et al. | β | 2024 | β |
| The Relationship Between Systemic Lupus Erythematosus and Osteoporosis Based on Different Ethnic Groups: a Two-Sample Mendelian Randomization Analysis. | Shi YK et al. | β | 2024 | β |
| The Role of Gut Microbiota in Thromboangiitis Obliterans: Cohort and Mendelian Randomization Study. | Sheng C et al. | β | 2024 | β |
| The Role of Inflammatory Biomarkers in Mediating the Effect of Inflammatory Bowel Disease on nonmalignant Digestive System Diseases: A Multivariable Mendelian Randomized Study. | Zhou S et al. | β | 2024 | β |
| Thyroid function variations within the reference range and cognitive function: A two-sample Mendelian randomization study. | Yu ZW et al. | β | 2024 | β |
| Type 2 diabetes and fasting glycemic traits are causal factors of frozen shoulder: a 2-sample Mendelian randomization analysis. | Xu T et al. | β | 2024 | β |
| Type 2 diabetes mediates the causal relationship between obesity and osteomyelitis: A Mendelian randomization study. | Liu HZ et al. | β | 2024 | β |
| Uncovering the molecular networks of ferroptosis in the pathogenesis of type 2 diabetes and its complications: a multi-omics investigation. | Dong C et al. | β | 2024 | β |
| Unraveling the association between gut microbiota and chemotherapy efficacy: a two-sample Mendelian randomization study. | Jia Z et al. | β | 2024 | β |
| Unravelling the Metabolic Underpinnings of Gestational Diabetes Mellitus: A Comprehensive Mendelian Randomisation Analysis Identifying Causal Metabolites and Biological Pathways. | Shen M et al. | β | 2024 | β |
| Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives. | Guo J et al. | β | 2024 | β |
| Unveiling the association between HMG-CoA reductase inhibitors and bladder cancer: a comprehensive analysis using Mendelian randomization, animal models, and transcriptomics. | Wei H et al. | β | 2024 | β |
| White Matter Imaging Phenotypes Mediate the Negative Causality of Mitochondrial DNA Copy Number on Sleep Apnea: A Bidirectional Mendelian Randomization Study and Mediation Analysis. | Ying Q et al. | β | 2024 | β |
| A bidirectional Mendelian randomization study about the role of morning plasma cortisol in attention deficit hyperactivity disorder. | Jue H et al. | β | 2023 | β |
| A Causal Atlas on Comorbidities in Idiopathic Pulmonary Fibrosis: A Bidirectional Mendelian Randomization Study. | Zhu J et al. | β | 2023 | β |
| A causal effects of gut microbiota in the development of migraine. | He Q et al. | β | 2023 | β |
| Age at menarche and polycystic ovary syndrome: A Mendelian randomization study. | Ma Y et al. | β | 2023 | β |
| A Mendelian randomization study on causal effects of leisure sedentary behaviour on the risk of rheumatoid arthritis. | Huang G et al. | β | 2023 | β |
| An empirical investigation into the impact of winner's curse on estimates from Mendelian randomization. | Jiang T et al. | β | 2023 | β |
| Assessing the causal relationship between COVID-19 and post-COVID-19 syndrome: A Mendelian randomisation study. | Tao Y et al. | β | 2023 | β |
| Assessing the causal relationships between human blood metabolites and the risk of NAFLD: A comprehensive mendelian randomization study. | Guo Z et al. | β | 2023 | β |
| Assessing the genetic relationship between gastroesophageal reflux disease and chronic respiratory diseases: a mendelian randomization study. | Cheng X et al. | β | 2023 | β |
| Association between brain structures and migraine: A bidirectional Mendelian randomization study. | Guo X et al. | β | 2023 | β |
| Association between gut microbiota and benign prostatic hyperplasia: a two-sample mendelian randomization study. | Xia D et al. | β | 2023 | β |
| Association between multiple sclerosis and cancer risk: An extensive review/meta and Mendelian randomization analyses. | Liu Q et al. | β | 2023 | β |
| Association of atopic dermatitis with autoimmune diseases: A bidirectional and multivariable two-sample mendelian randomization study. | Zhou W et al. | β | 2023 | β |
| Association of atopic dermatitis with conjunctivitis and other ocular surface diseases: A bidirectional two-sample Mendelian randomization study. | Zhou W et al. | β | 2023 | β |
| Association of gut microbiota and dietary component intake with COVID-19: A mendelian randomization study. | Zhang H et al. | β | 2023 | β |
| Associations between attention-deficit/hyperactivity disorder and allergic diseases: a two-sample Mendelian randomization study. | Zhang X et al. | β | 2023 | β |
| Associations between body circumference and testosterone levels and risk of metabolic dysfunction-associated fatty liver disease: a mendelian randomization study. | Ning L et al. | β | 2023 | β |
| Body mass index and the risk of abdominal hernia: a Mendelian randomization study. | Li Z et al. | β | 2023 | β |
| Can Intelligence Affect Alcohol-, Smoking-, and Physical Activity-Related Behaviors? A Mendelian Randomization Study. | Li H et al. | β | 2023 | β |
| Cannabis use and atherosclerotic cardiovascular disease: a Mendelian randomization study. | de La Harpe R et al. | β | 2023 | β |
| Casual association between childhood body mass index and risk of psoriasis: A Mendelian randomization study. | Li Y et al. | β | 2023 | β |
| Causal association between body mass index and temporomandibular disorders: a bidirectional two-sample Mendelian randomization analysis. | Chen X et al. | β | 2023 | β |
| Causal association between placental growth factor and coronary heart disease: a Mendelian randomization study. | Zuo B et al. | β | 2023 | β |
| Causal association between serum 25-Hydroxyvitamin D levels and cutaneous melanoma: a two-sample Mendelian randomization study. | Cai B et al. | β | 2023 | β |
| Causal association between tea intake and risk for gout: a Mendelian randomization study. | Liang X et al. | β | 2023 | β |
| Causal association of lipoprotein-associated phospholipids on the risk of sepsis: a Mendelian randomization study. | Zeng L et al. | β | 2023 | β |
| Causal associations between gastroesophageal reflux disease and lung cancer risk: A Mendelian randomization study. | Li L et al. | β | 2023 | β |
| Causal Associations Between Gut Microbiota and Psoriasis: A Mendelian Randomization Study. | Zang C et al. | β | 2023 | β |
| Causal associations between gut microbiota, gut microbiota-derived metabolites, and cerebrovascular diseases: a multivariable Mendelian randomization study. | Lin D et al. | β | 2023 | β |
| Causal associations between prodromal infection and neuromyelitis optica spectrum disorder: A Mendelian randomization study. | Wang L et al. | β | 2023 | β |
| Causal associations between serum amino acid levels and osteoarthritis: a Mendelian randomization study. | Cui ZY et al. | β | 2023 | β |
| Causal associations of thyroid function and sudden sensorineural hearing loss: a bidirectional and multivariable Mendelian randomization study. | Chen J et al. | β | 2023 | β |
| Causal effect of beta-blockers on the risk of lung cancer: a Mendelian randomization study. | Lu Y et al. | β | 2023 | β |
| Causal effects between atrial fibrillation and heart failure: evidence from a bidirectional Mendelian randomization study. | Zhang Z et al. | β | 2023 | β |
| Causal Effects between Gut Microbiome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Two-Sample Mendelian Randomization Study. | He G et al. | β | 2023 | β |
| Causal Effects of Gut Microbiota on Sleep-Related Phenotypes: A Two-Sample Mendelian Randomization Study. | Yue M et al. | β | 2023 | β |
| Causal effects of inflammatory bowel diseases on the risk of kidney stone disease: a two-sample bidirectional mendelian randomization. | Zhang H et al. | β | 2023 | β |
| Causal effects of specific gut microbiota on musculoskeletal diseases: a bidirectional two-sample Mendelian randomization study. | Chen S et al. | β | 2023 | β |
| Causal influence of muscle weakness on cardiometabolic diseases and osteoporosis. | Mou X et al. | β | 2023 | β |
| Causality between urate levels with sarcopenia-related traits: a bi-directional Mendelian randomization study. | Lin Y et al. | β | 2023 | β |
| Causality of Diabetic Nephropathy and Age-Related Macular Degeneration: A Mendelian Randomization Study. | Chen X et al. | β | 2023 | β |
| Causal links between socioeconomic status, leisure sedentary behaviours and gastro-oesophageal reflux disease: a multivariable two-sample Mendelian randomisation study. | Lian X et al. | β | 2023 | β |
| Causal relationship between blood metabolites and risk of five infections: a Mendelian randomization study. | Wei Z et al. | β | 2023 | β |
| Causal relationship between gut microbiota and kidney diseases: a two-sample Mendelian randomization study. | Feng Z et al. | β | 2023 | β |
| Causal relationship between gut microbiota and urticaria: a bidirectional two-sample mendelian randomization study. | Shi YZ et al. | β | 2023 | β |
| Causal relationship between human blood omega-3 fatty acids and the risk of epilepsy: A two-sample Mendelian randomization study. | Liang Z et al. | β | 2023 | β |
| Causal relationship between Type 1 diabetes and osteoporosis and fracture occurrence: a two-sample Mendelian randomization analysis. | Tang Y et al. | β | 2023 | β |
| Causal relationship between type 2 diabetes mellitus and bone mineral density: a Mendelian randomization study in an East Asian population. | Huang G et al. | β | 2023 | β |
| Causal relationships between COVID-19 and osteoporosis: a two-sample Mendelian randomization study in European population. | Zhang K et al. | β | 2023 | β |
| Causal relationships of excessive daytime napping with atherosclerosis and cardiovascular diseases: a Mendelian randomization study. | Chen J et al. | β | 2023 | β |
| Constipation and cardiovascular disease: A two-sample Mendelian randomization analysis. | Dong Q et al. | β | 2023 | β |
| COVID-19 has causal effects on cancer risk? Something we might ignore. | Sun Z et al. | β | 2023 | β |
| Data Integration in Causal Inference. | Shi X et al. | β | 2023 | β |
| Dissecting the association between gut microbiota and liver cancer in European and East Asian populations using Mendelian randomization analysis. | Jiang H et al. | β | 2023 | β |
| Dissecting the causal association between social or physical inactivity and depression: a bidirectional two-sample Mendelian Randomization study. | Zhao G et al. | β | 2023 | β |
| Disturbance of skin sensation and autism spectrum disorder: A bidirectional Mendelian randomization study. | Zhong X et al. | β | 2023 | β |
| DNA methylation analysis is used to identify novel genetic loci associated with circulating fibrinogen levels in blood. | Hahn J et al. | β | 2023 | β |
| Do testosterone and sex hormone-binding globulin affect cancer risk? A Mendelian randomization and bioinformatics study. | Liu X et al. | β | 2023 | β |
| Effect of genetically determined BCAA levels on cardiovascular diseases and their risk factors: A Mendelian randomization study. | Zuo Z et al. | β | 2023 | β |
| Effect of interleukin-17 on periodontitis development: An instrumental variable analysis. | Baumeister SE et al. | β | 2023 | β |
| Effects of insomnia and non-vasomotor menopausal symptoms on coronary heart disease risk: a mendelian randomization study. | Lian IB et al. | β | 2023 | β |
| Endometriosis and epithelial ovarian cancer: a two-sample Mendelian randomization analysis. | Wang L et al. | β | 2023 | β |
| Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI. | Yang Y et al. | β | 2023 | β |
| Evaluating the causal relationship between human blood metabolites and gastroesophageal reflux disease. | Hu JY et al. | β | 2023 | β |
| Evaluating the effect of childhood sunburn on the risk of cutaneous melanoma through Mendelian randomization. | Zhong S et al. | β | 2023 | β |
| Evaluation of causal associations between interleukin-18 levels and immune-mediated inflammatory diseases: a Mendelian randomization study. | Wu J et al. | β | 2023 | β |
| Exploring blood metabolites and thyroid disorders: a bidirectional mendelian randomization study. | Zhang X et al. | β | 2023 | β |
| Exploring causal effects of smoking and alcohol related lifestyle factors on self-report tiredness: A Mendelian randomization study. | Li H et al. | β | 2023 | β |
| Exploring the causal effects of the gut microbiome on serum lipid levels: A two-sample Mendelian randomization analysis. | Guo G et al. | β | 2023 | β |
| Exploring the Causality Between Body Mass Index and Sepsis: A Two-Sample Mendelian Randomization Study. | Wang J et al. | β | 2023 | β |
| Exploring the causal relationship between inflammatory bowel disease and sarcopenia-related traits: a two-sample Mendelian randomization analysis. | Lin S et al. | β | 2023 | β |
| Genetically predicted 486 blood metabolites in relation to risk of colorectal cancer: A Mendelian randomization study. | Yun Z et al. | β | 2023 | β |
| Genetic association between interleukin-17 and susceptibility to rheumatoid arthritis. | Zhao R et al. | β | 2023 | β |
| Genetic Causal Association Between the Gut Microbiome and Intracranial Aneurysm and Subarachnoid Hemorrhage: A Two-Sample Mendelian Randomization Study. | He M et al. | β | 2023 | β |
| Genetic causal relationship between gut microbiome and psoriatic arthritis: a bidirectional two-sample Mendelian randomization study. | Qian X et al. | β | 2023 | β |
| Genetic evidence for the causal linkage between telomere length and aortic aneurysm risk: A Mendelian randomisation study. | Zhang R et al. | β | 2023 | β |
| Genetic support of a causal relationship between cannabis use and educational attainment: a two-sample Mendelian randomization study of European ancestry. | Chen D et al. | β | 2023 | β |
| Gut microbiota and risk of five common cancers: A univariable and multivariable Mendelian randomization study. | Wei Z et al. | β | 2023 | β |
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| Gut microbiota and SjΓΆgren's syndrome: a two-sample Mendelian randomization study. | Cao Y et al. | β | 2023 | β |
| Identifying and ranking causal association between gut microbiota and neuroticism. | Yang J et al. | β | 2023 | β |
| Identifying and ranking causal microbial biomarkers for colorectal cancer at different cancer subsites and stages: a Mendelian randomization study. | Li H et al. | β | 2023 | β |
| Immune-mediated inflammatory diseases and leukocyte telomere length: A Mendelian randomization study. | Liu M et al. | β | 2023 | β |
| Impairment of kidney function and kidney cancer: A bidirectional Mendelian randomization study. | Lin Y et al. | β | 2023 | β |
| Inflammatory markers and the risk of idiopathic sudden sensorineural hearing loss: A Mendelian randomization study. | Zhou T et al. | β | 2023 | β |
| Integrated Analyses of Single-Cell Transcriptome and Mendelian Randomization Reveal the Protective Role of Resistin in Sepsis Survival in Intensive Care Unit. | Chen H et al. | β | 2023 | β |
| Investigating the shared genetic architecture and causal relationship between pain and neuropsychiatric disorders. | Chen M et al. | β | 2023 | β |
| Investigation of the causal relationship between breast cancer and autoimmune diseases: A bidirectional mendelian randomization study. | Lu Y et al. | β | 2023 | β |
| Iron status and obesity-related traits: A two-sample bidirectional Mendelian randomization study. | Zhou Z et al. | β | 2023 | β |
| Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response. | Dekkers KF et al. | β | 2023 | β |
| Lipid Metabolism Traits Mediate the Effect of Psoriasis on Myocardial Infarction Risk: A Two-Step Mendelian Randomization Study. | Ding Y et al. | β | 2023 | β |
| Male infertility risk and gut microbiota: a Mendelian randomization study. | Fu ZD et al. | β | 2023 | β |
| Mendelian randomization analysis for attention deficit/hyperactivity disorder: studying a broad range of exposures and outcomes. | Soler Artigas M et al. | β | 2023 | β |
| Mendelian Randomization Analysis Reveals a Complex Genetic Interplay among Atopic Dermatitis, Asthma, and Gastroesophageal Reflux Disease. | Ahn K et al. | β | 2023 | β |
| Mendelian randomization analysis to investigate the gut microbiome in oral and oropharyngeal cancer. | Zhang Q et al. | β | 2023 | β |
| Mendelian Randomization and Transcriptome-Wide Association Analysis Identified Genes That Were Pleiotropically Associated with Intraocular Pressure. | Yang Z et al. | β | 2023 | β |
| Mendelian randomization study on the causal effect of serum IgA levels on H7N9 avian influenza A virus susceptibility. | Liao Q et al. | β | 2023 | β |
| Mendelian-randomization study reveals causal relationships between nitrogen dioxide and gut microbiota. | Yang H et al. | β | 2023 | β |
| Mendelian randomization study reveals the effect of idiopathic pulmonary fibrosis on the risk of erectile dysfunction. | Zhang K et al. | β | 2023 | β |
| Mendelian randomization study shows a causal effect of asthma on chronic obstructive pulmonary disease risk. | Li Y et al. | β | 2023 | β |
| Mendelian randomization supports causality between gut microbiota and chronic hepatitis B. | Zhang Q et al. | β | 2023 | β |
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| Multi-response Mendelian randomization: Identification of shared and distinct exposures for multimorbidity and multiple related disease outcomes. | Zuber V et al. | β | 2023 | β |
| No association effect of genetic polymorphism was observed between polycystic ovary syndrome and cardiovascular diseases risk: a mendelian randomization study. | Zhang X et al. | β | 2023 | β |
| No causal association between COVID-19 and sepsis: a bidirectional two-sample Mendelian randomization study. | Lu H et al. | β | 2023 | β |
| No causal genetic relationships between atrial fibrillation and vascular dementia: A bidirectional Mendelian randomization study. | Gao YF et al. | β | 2023 | β |
| Opportunities and challenges in using instrumental variables to study causal effects in nonrandomized stress and trauma research. | Matthay EC et al. | β | 2023 | β |
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| Plasma lipids, alcohol intake frequency and risk of Osteoarthritis: a Mendelian randomization study. | Wen MT et al. | β | 2023 | β |
| Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses. | Yuan S et al. | β | 2023 | β |
| Proteomics Analysis of Genetic Liability of Abdominal Aortic Aneurysm Identifies Plasma Neogenin and Kit Ligand: The ARIC Study. | Steffen BT et al. | β | 2023 | β |
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| Risk relationship between leukocyte telomere length and constipation: a Mendelian randomization study. | Chi Z et al. | β | 2023 | β |
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| Socioeconomic status may affect association of vegetable intake with risk of ischemic cardio-cerebral vascular disease: a Mendelian randomization study. | Huang J et al. | β | 2023 | β |
| The association between basal metabolic rate and osteoarthritis: a Mendelian randomization study. | Zhou J et al. | β | 2023 | β |
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| The bidirectional relationship between Alzheimer's disease (AD) and epilepsy: A Mendelian randomization study. | Xu L et al. | β | 2023 | β |
| The Casual Association Inference for the Chain of Falls Risk Factors-Falls-Falls Outcomes: A Mendelian Randomization Study. | Wu JX et al. | β | 2023 | β |
| The causal association between systemic inflammatory regulators and primary ovarian insufficiency: a bidirectional mendelian randomization study. | Wang J et al. | β | 2023 | β |
| The causal associations of non-alcoholic fatty liver disease with blood pressure and the mediating effects of cardiometabolic risk factors: A Mendelian randomization study. | Zhang Z et al. | β | 2023 | β |
| The causal effects of age at menarche, age at first live birth, and estradiol levels on systemic lupus erythematosus: A two-sample Mendelian randomization analysis. | Zhang Y et al. | β | 2023 | β |
| The Causal Effects of Cholelithiasis on Acute Pancreatitis and Pancreatic Cancer: A Large Sample Size Mendelian Randomization Analysis. | Rao M et al. | β | 2023 | β |
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| The Causal Impact of the Gut Microbiota on Respiratory Tuberculosis Susceptibility. | Wen J et al. | β | 2023 | β |
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| The Frailty Index and colon cancer: a 2-sample Mendelian-randomization study. | Gao L et al. | β | 2023 | β |
| The immune factors have complex causal regulation effects on inflammatory bowel disease. | Qiu B et al. | β | 2023 | β |
| The impact of serum magnesium and calcium on the risk of epilepsy: A mendelian randomization study. | Guo X et al. | β | 2023 | β |
| The interactions between host genome and gut microbiome increase the risk of psychiatric disorders: Mendelian randomization and biological annotation. | Xiao L et al. | β | 2023 | β |
| The relationship between autoimmune thyroid disease, thyroid nodules and sleep traits: a Mendelian randomization study. | Wang S et al. | β | 2023 | β |
| Two-sample Mendelian randomization analysis evaluates causal associations between inflammatory bowel disease and osteoporosis. | Dai Z et al. | β | 2023 | β |
| [Type 1 diabetes mellitus is likely to increase the risk of thyrotoxicdsis: a two-sample Mendelian randomization study]. | Zhan W et al. | β | 2023 | β |
| Understanding the relationship between circulating lipids and risk of chronic kidney disease: a prospective cohort study and large-scale genetic analyses. | Wang Y et al. | β | 2023 | β |
| Unlocking the Medicinal Mysteries: Preventing Lacunar Stroke with Drug Repurposing. | Zhang L et al. | β | 2023 | β |
| Unraveling the relationships between alpha- and beta-adrenergic modulation and the risk of heart failure. | Baudier C et al. | β | 2023 | β |
| Work-related factors and risk of amyotrophic lateral sclerosis: A multivariable Mendelian randomization study. | Li M et al. | β | 2023 | β |
| Absence of causal association between Vitamin D and bone mineral density across the lifespan: a Mendelian randomization study. | Tang Y et al. | β | 2022 | β |
| ADHD and its neurocognitive substrates: A two sample Mendelian randomization study. | Ahn K et al. | β | 2022 | β |
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| A Guide for Understanding and Designing Mendelian Randomization Studies in the Musculoskeletal Field. | Hartley AE et al. | β | 2022 | β |
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| A putative causality of vitamin D in common diseases: A mendelian randomization study. | Liu H et al. | β | 2022 | β |
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| Assessing the Relationship Between High-sensitivity C-reactive Protein and Kidney Function Employing Mendelian Randomization in the Japanese Community-based J-MICC Study. | Fujii R et al. | β | 2022 | β |
| Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study. | Li P et al. | β | 2022 | β |
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| Association of ICU Admission and Outcomes in Sepsis and Acute Respiratory Failure. | Anesi GL et al. | β | 2022 | β |
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| A two-sample Mendelian randomization analysis of modifiable risk factors and intracranial aneurysms. | Tian D et al. | β | 2022 | β |
| Body Mass Index and the Risk of Atrial Fibrillation: A Mendelian Randomization Study. | Ma M et al. | β | 2022 | β |
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| Causal association between rheumatoid arthritis and celiac disease: A bidirectional two-sample mendelian randomization study. | Hua L et al. | β | 2022 | β |
| Causal associations between blood pressure and the risk of myocardial infarction: A bidirectional Mendelian randomization study. | Yang ZQ et al. | β | 2022 | β |
| Causal Effects of Circulating Cytokines on the Risk of Psoriasis Vulgaris: A Mendelian Randomization Study. | Zhao P et al. | β | 2022 | β |
| Causal effects of homocysteine levels on the components of sarcopenia: A two-sample mendelian randomization study. | Yu H et al. | β | 2022 | β |
| Causal relationship between gut microbiota and serum vitamin D: evidence from genetic correlation and Mendelian randomization study. | Yang X et al. | β | 2022 | β |
| Causal relationships between metabolic-associated fatty liver disease and iron status: Two-sample Mendelian randomization. | He H et al. | β | 2022 | β |
| Causal roles of circulating adiponectin in osteoporosis and cancers. | He B et al. | β | 2022 | β |
| Causal Roles of Sleep Duration in Osteoporosis and Cardiometabolic Diseases: A Mendelian Randomization Study. | He B et al. | β | 2022 | β |
| Circulating adipokine levels and preeclampsia: A bidirectional Mendelian randomization study. | Chen X et al. | β | 2022 | β |
| Coffee Types and Type 2 Diabetes Mellitus: Large-Scale Cross-Phenotype Association Study and Mendelian Randomization Analysis. | Wang X et al. | β | 2022 | β |
| Combining evidence from Mendelian randomization and colocalization: Review and comparison of approaches. | Zuber V et al. | β | 2022 | β |
| COVID-19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis. | Zhang H et al. | β | 2022 | β |
| Cross-fitted instrument: A blueprint for one-sample Mendelian randomization. | Denault WRP et al. | β | 2022 | β |
| Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. | Martin S et al. | β | 2022 | β |
| Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization. | Batool F et al. | β | 2022 | β |
| Do sex hormones confound or mediate the effect of chronotype on breast and prostate cancer? A Mendelian randomization study. | Hayes BL et al. | β | 2022 | β |
| Effect of blood lipids and lipid-lowering therapies on osteoarthritis risk: A Mendelian randomization study. | Wang Z et al. | β | 2022 | β |
| Effects of Gut Microbiota and Metabolites on Heart Failure and Its Risk Factors: A Two-Sample Mendelian Randomization Study. | Luo Q et al. | β | 2022 | β |
| Elevated blood pressure, antihypertensive medications and bone health in the population: revisiting old hypotheses and exploring future research directions. | Canoy D et al. | β | 2022 | β |
| Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study. | Li GH et al. | β | 2022 | β |
| Examining Health Outcomes in Juvenile Idiopathic Arthritis: A Genetic Epidemiology Study. | Clarke SLN et al. | β | 2022 | β |
| Excess comorbidities in gout: the causal paradigm and pleiotropic approaches to care. | Choi HK et al. | β | 2022 | β |
| Exploring Lead loci shared between schizophrenia and Cardiometabolic traits. | He Q et al. | β | 2022 | β |
| Family Socioeconomic Position and Lung Cancer Risk: A Meta-Analysis and a Mendelian Randomization Study. | Zou X et al. | β | 2022 | β |
| Fibrinogen in Alzheimer's Disease, Parkinson's Disease and Lewy Body Dementia: A Mendelian Randomization Study. | Zhang H et al. | β | 2022 | β |
| Genetically Predicted Circulating Omega-3 Fatty Acids Levels Are Causally Associated With Increased Risk for Systemic Lupus Erythematosus. | Wang P et al. | β | 2022 | β |
| Genetically predicted tea intake increases the risk of osteoarthritis: A Mendelian randomization study. | Li G et al. | β | 2022 | β |
| Genetically supported causality between benign prostate hyperplasia and urinary bladder neoplasms: A mendelian randomization study. | Du W et al. | β | 2022 | β |
| Genetic estimation of correlations and causalities between multifaceted modifiable factors and gastro-oesophageal reflux disease. | Sun Y et al. | β | 2022 | β |
| Genetic liability between COVID-19 and heart failure: evidence from a bidirectional Mendelian randomization study. | Wang H et al. | β | 2022 | β |
| Genetic liability for prescription opioid use and risk of cardiovascular diseases: a multivariable Mendelian randomization study. | Cai J et al. | β | 2022 | β |
| Genetic predisposition to neurodegenerative diseases and risk of stroke: A Mendelian randomization study. | Li F et al. | β | 2022 | β |
| Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans. | Yang W et al. | β | 2022 | β |
| Genome-wide association study meta-analysis identifies three novel loci for circulating anti-MΓΌllerian hormone levels in women. | Verdiesen RMG et al. | β | 2022 | β |
| Genome-Wide Integration of Genetic and Genomic Studies of Atopic Dermatitis: Insights into Genetic Architecture and Pathogenesis. | Chen Y et al. | β | 2022 | β |
| Gut microbiota alterations may increase the risk of prescription opioid use, but not vice versa: A two-sample bi-directional Mendelian randomization study. | Lin L et al. | β | 2022 | β |
| GWAS of depression in 4,520 individuals from the Russian population highlights the role of <i>MAGI2</i> (<i>S-SCAM</i>) in the gut-brain axis. | Pinakhina D et al. | β | 2022 | β |
| High-Density Lipoprotein 3 Cholesterol and Primary Open-Angle Glaucoma: Metabolomics and Mendelian Randomization Analyses. | Nusinovici S et al. | β | 2022 | β |
| Identifying molecular mediators of the relationship between body mass index and endometrial cancer risk: a Mendelian randomization analysis. | Hazelwood E et al. | β | 2022 | β |
| Intelligence, education level, and risk of Parkinson's disease in European populations: A Mendelian randomization study. | Shi J et al. | β | 2022 | β |
| Investigating genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being. | Cai L et al. | β | 2022 | β |
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| Large-scale genetic correlation scanning and causal association between deep vein thrombosis and human blood metabolites. | Luo P et al. | β | 2022 | β |
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| Mendelian Randomization: Principles and its usage in Lp(a) research. | Lamina C | β | 2022 | β |
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| Mendelian randomization study of the effect of coronary artery calcification on atherosclerotic cardiovascular diseases. | Sae-Jie W et al. | β | 2022 | β |
| Mendelian randomization supports the causal role of fasting glucose on periodontitis. | Wang Y et al. | β | 2022 | β |
| Multi-ancestry fine-mapping improves precision to identify causal genes in transcriptome-wide association studies. | Lu Z et al. | β | 2022 | β |
| No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis. | Yin KJ et al. | β | 2022 | β |
| Osteoarthritis and cardiovascular disease: A Mendelian randomization study. | Wang Z et al. | β | 2022 | β |
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| Polyunsaturated Fatty Acids Level and Bone Mineral Density: A Two-Sample Mendelian Randomization Study. | Wang L et al. | β | 2022 | β |
| Prioritization of risk genes in multiple sclerosis by a refined Bayesian framework followed by tissue-specificity and cell type feature assessment. | Liu A et al. | β | 2022 | β |
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| Rho GTPase gene expression and breast cancer risk: a Mendelian randomization analysis. | Kazmi N et al. | β | 2022 | β |
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| Smoking, alcohol consumption, diabetes, body mass index, and peptic ulcer risk: A two-sample Mendelian randomization study. | Liu Y et al. | β | 2022 | β |
| Smoking Status and Type 2 Diabetes, and Cardiovascular Disease: A Comprehensive Analysis of Shared Genetic Etiology and Causal Relationship. | Chi Y et al. | β | 2022 | β |
| Socioeconomic status, individual behaviors and risk for mental disorders: A Mendelian randomization study. | Cai J et al. | β | 2022 | β |
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| Systematic review of Mendelian randomization studies on risk of cancer. | Markozannes G et al. | β | 2022 | β |
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| Telomere Length and Development of Systemic Lupus Erythematosus: A Mendelian Randomization Study. | Wang XF et al. | β | 2022 | β |
| The Association between Blood Lipids and Systemic Lupus Erythematosus: A Two-Sample Mendelian Randomization Research. | Ding Y et al. | β | 2022 | β |
| The association between circulating docosahexaenoic acid and lung cancer: A Mendelian randomization study. | Zhao H et al. | β | 2022 | β |
| The association between plasma chemokines and breast cancer risk and prognosis: A mendelian randomization study. | Yu X et al. | β | 2022 | β |
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| The causal association of polyunsaturated fatty acids with allergic disease: A two-sample Mendelian randomization study. | Li Y et al. | β | 2022 | β |
| The causal relationship between allergic diseases and heart failure: Evidence from Mendelian randomization study. | Guo YG et al. | β | 2022 | β |
| The Causal Relationships Between Extrinsic Exposures and Risk of Prostate Cancer: A Phenome-Wide Mendelian Randomization Study. | Gu D et al. | β | 2022 | β |
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| An atlas on risk factors for multiple sclerosis: a Mendelian randomization study. | Yuan S et al. | β | 2021 | β |
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| Causal Effect of Serum Magnesium on Osteoporosis and Cardiometabolic Diseases. | He B et al. | β | 2021 | β |
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| Causal effects of homocysteine levels on the changes of bone mineral density and risk for bone fracture: A two-sample mendelian randomization study. | Wang P et al. | β | 2021 | β |
| Causal relationship between educational attainment and the risk of rheumatoid arthritis: a Mendelian randomization study. | Huang G et al. | β | 2021 | β |
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| Genetically Predicted Circulating Concentrations of Micronutrients and Risk of Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study. | Mu C et al. | β | 2021 | β |
| Genetic and phenotypic analysis of the causal relationship between aging and COVID-19. | Ying K et al. | β | 2021 | β |
| Genetic Determinants of Increased Body Mass Index Partially Mediate the Effect of Elevated Birth Weight on the Increased Risk of Atrial Fibrillation. | Chen S et al. | β | 2021 | β |
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| Gluten-free Diet Reduces the Risk of Irritable Bowel Syndrome: A Mendelian Randomization Analysis. | Sun Y et al. | β | 2021 | β |
| Gut Microbiota and Psychiatric Disorders: A Two-Sample Mendelian Randomization Study. | Ni JJ et al. | β | 2021 | β |
| Habitual consumption of alcohol with meals and lung cancer: a Mendelian randomization study. | Chen C et al. | β | 2021 | β |
| Integrating brain imaging endophenotypes with GWAS for Alzheimer's disease. | Knutson KA et al. | β | 2021 | β |
| Investigating the Causal Relationship Between Physical Activity and Chronic Back Pain: A Bidirectional Two-Sample Mendelian Randomization Study. | Gao S et al. | β | 2021 | β |
| Iron Status May Not Affect Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study. | Cai J et al. | β | 2021 | β |
| Letter to the Editor - Increased risk of ischemic heart disease in patients with bipolar disorder: A population-based study. | Ge F et al. | β | 2021 | β |
| Leveraging Genetic Data to Elucidate the Relationship Between COVID-19 and Ischemic Stroke. | Zuber V et al. | β | 2021 | β |
| Life Course Adiposity and Alzheimer's Disease: A Mendelian Randomization Study. | Li X et al. | β | 2021 | β |
| Long-term cost-effectiveness of interventions for obesity: A mendelian randomisation study. | Harrison S et al. | β | 2021 | β |
| Lower Lymphocyte Count is Associated With Increased Risk of Parkinson's Disease. | Jensen MP et al. | β | 2021 | β |
| Mendelian Randomization Highlights the Causal Role of Normal Thyroid Function on Blood Lipid Profiles. | Wang Y et al. | β | 2021 | β |
| Mendelian Randomization Identifies the Potential Causal Impact of Dietary Patterns on Circulating Blood Metabolites. | Taba N et al. | β | 2021 | β |
| Mendelian randomization study on atrial fibrillation and cardiovascular disease subtypes. | Kwok MK et al. | β | 2021 | β |
| Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian randomisation study. | Li S et al. | β | 2021 | β |
| No Casual Relationship Between T2DM and the Risk of Infectious Diseases: A Two-Sample Mendelian Randomization Study. | Wang H et al. | β | 2021 | β |
| No Causal Association Between Adiponectin and the Risk of Rheumatoid Arthritis: A Mendelian Randomization Study. | Chen H et al. | β | 2021 | β |
| Non-Causal Effects of Asthma on COVID-19 Susceptibility and Severity. | Qiu LJ et al. | β | 2021 | β |
| Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts. | Pistis G et al. | β | 2021 | β |
| Plasma Proteomics of Renal Function: A Transethnic Meta-Analysis and Mendelian Randomization Study. | MatΓas-GarcΓa PR et al. | β | 2021 | β |
| Pleiotropy robust methods for multivariable Mendelian randomization. | Grant AJ et al. | β | 2021 | β |
| Relationship Between Serum Amino Acid Levels and Bone Mineral Density: A Mendelian Randomization Study. | Cui Z et al. | β | 2021 | β |
| Rheumatoid Arthritis and Cardio-Cerebrovascular Disease: A Mendelian Randomization Study. | Qiu S et al. | β | 2021 | β |
| Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. | Lagou V et al. | β | 2021 | β |
| Sex Steroids and Osteoarthritis: A Mendelian Randomization Study. | Yan YS et al. | β | 2021 | β |
| Shared associations identify causal relationships between gene expression and immune cell phenotypes. | Gasperi C et al. | β | 2021 | β |
| Suggestive Evidence for Causal Effect of Leptin Levels on Risk for Anorexia Nervosa: Results of a Mendelian Randomization Study. | Peters T et al. | β | 2021 | β |
| Systematic Influence of Circulating Bilirubin Levels on Osteoporosis. | Zhao J et al. | β | 2021 | β |
| The Association of Waist Circumference and the Risk of Deep Vein Thrombosis. | Lin C et al. | β | 2021 | β |
| The causal effect of interleukin-17 on the risk of psoriatic arthritis: a Mendelian randomization study. | Wu D et al. | β | 2021 | β |
| The Causal Effects of Insomnia on Bipolar Disorder, Depression, and Schizophrenia: A Two-Sample Mendelian Randomization Study. | Huang P et al. | β | 2021 | β |
| The Effect of Attention Deficit/Hyperactivity Disorder on Physical Health Outcomes: A 2-Sample Mendelian Randomization Study. | Leppert B et al. | β | 2021 | β |
| The Genetic Association of Polycystic Ovary Syndrome and the Risk of Endometrial Cancer: A Mendelian Randomization Study. | Chen H et al. | β | 2021 | β |
| The Gut Microbiome and Osteoarthritis: A Two-Sample Mendelian Randomization Study. | Lee YH et al. | β | 2021 | β |
| The Role of C-Reactive Protein and Fibrinogen in the Development of Intracerebral Hemorrhage: A Mendelian Randomization Study in European Population. | Wang B et al. | β | 2021 | β |
| The use of negative control outcomes in Mendelian randomization to detect potential population stratification. | Sanderson E et al. | β | 2021 | β |
| Two-Sample Mendelian Randomization Analysis of Associations Between Periodontal Disease and Risk of Cancer. | Corlin L et al. | β | 2021 | β |
| Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney. | Eales JM et al. | β | 2021 | β |
| Using genetic variants to evaluate the causal effect of serum vitamin D concentration on COVID-19 susceptibility, severity and hospitalization traits: a Mendelian randomization study. | Cui Z et al. | β | 2021 | β |
| A comparison of robust Mendelian randomization methods using summary data. | Slob EAW et al. | β | 2020 | β |
| A Mendelian randomization study of telomere length and blood-cell traits. | Adams CD et al. | β | 2020 | β |
| A Mendelian randomization study of the causal association between anxiety phenotypes and schizophrenia. | Jones HJ et al. | β | 2020 | β |
| A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer. | Gormley M et al. | β | 2020 | β |
| A multivariable Mendelian randomization to appraise the pleiotropy between intelligence, education, and bipolar disorder in relation to schizophrenia. | Adams CD | β | 2020 | β |
| Are vitamins relevant to cancer risks? A Mendelian randomization investigation. | Cheng WW et al. | β | 2020 | β |
| A unified framework for joint-tissue transcriptome-wide association and Mendelian randomization analysis. | Zhou D et al. | β | 2020 | β |
| Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses. | Brumpton B et al. | β | 2020 | β |
| Body mass index and height and risk of cutaneous melanoma: Mendelian randomization analyses. | Dusingize JC et al. | β | 2020 | β |
| Body Mass Index and Polycystic Ovary Syndrome: A 2-Sample Bidirectional Mendelian Randomization Study. | Zhao Y et al. | β | 2020 | β |
| Cancer risks in patients with vitiligo: a Mendelian randomization study. | Wen Y et al. | β | 2020 | β |
| Can increasing years of schooling reduce type 2 diabetes (T2D)?: Evidence from a Mendelian randomization of T2D and 10 of its risk factors. | Adams CD et al. | β | 2020 | β |
| Causal association between periodontitis and risk of rheumatoid arthritis and systemic lupus erythematosus: aΒ Mendelian randomization. | Bae SC et al. | β | 2020 | β |
| Circulating Glutamine and Alzheimer's Disease: A Mendelian Randomization Study. | Adams CD | β | 2020 | β |
| Education, intelligence, and amyotrophic lateral sclerosis: A Mendelian randomization study. | Zhang L et al. | β | 2020 | β |
| Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework. | Cho Y et al. | β | 2020 | β |
| Exploring the genetic relationship between hearing impairment and Alzheimer's disease. | Mitchell BL et al. | β | 2020 | β |
| Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis. | Parisinos CA et al. | β | 2020 | β |
| Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study. | Cai L et al. | β | 2020 | β |
| Human genetic determinants of the gut microbiome and their associations with health and disease: a phenome-wide association study. | Groot HE et al. | β | 2020 | β |
| Identification of Genetic Variants for Female Obesity and Evaluation of the Causal Role of Genetically Defined Obesity in Polycystic Ovarian Syndrome. | Ahn Y et al. | β | 2020 | β |
| Investigating causal relationships between Body Mass Index and risk of atopic dermatitis: a Mendelian randomization analysis. | Yew YW et al. | β | 2020 | β |
| Investigation of the Causal Association between Long-Chain n-6 Polyunsaturated Fatty Acid Synthesis and the Risk of Type 2 Diabetes: A Mendelian Randomization Analysis. | Zulyniak MA et al. | β | 2020 | β |
| Lipid and Ischemic Heart Disease Revisited: Mendelian Randomization Analysis. | Sung J | β | 2020 | β |
| Mendelian randomisation analysis of circulating adipokines and C-reactive protein on breast cancer risk. | Robinson T et al. | β | 2020 | β |
| Mendelian randomization study of inflammatory bowel disease and bone mineral density. | Wu F et al. | β | 2020 | β |
| Mendelian randomization study of telomere length and bone mineral density. | Wu F et al. | β | 2020 | β |
| Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. | Erzurumluoglu AM et al. | β | 2020 | β |
| Power calculation for the general two-sample Mendelian randomization analysis. | Deng L et al. | β | 2020 | β |
| Protein QTL analysis of IGF-I and its binding proteins provides insights into growth biology. | Bartell E et al. | β | 2020 | β |
| Quantitative genetic analysis deciphers the impact of cis and trans regulation on cell-to-cell variability in protein expression levels. | Morgan MD et al. | β | 2020 | β |
| Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization. | Zuber V et al. | β | 2020 | β |
| Shared genetic architecture and casual relationship between leptin levels and type 2 diabetes: large-scale cross-trait meta-analysis and Mendelian randomization analysis. | Wang X et al. | β | 2020 | β |
| Shared genetic etiology underlying Alzheimer's disease and major depressive disorder. | Lutz MW et al. | β | 2020 | β |
| Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways. | Jamieson E et al. | β | 2020 | β |
| Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study. | Smit RAJ et al. | β | 2020 | β |
| Strengthening Causal Inference for Complex Disease Using Molecular Quantitative Trait Loci. | Neumeyer S et al. | β | 2020 | β |
| Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study. | Howell AE et al. | β | 2020 | β |
| The Causal Effects of Blood Iron and Copper on Lipid Metabolism Diseases: Evidence from Phenome-Wide Mendelian Randomization Study. | Zhou J et al. | β | 2020 | β |
| The causal effects of health conditions and risk factors on social and socioeconomic outcomes: Mendelian randomization in UK Biobank. | Harrison S et al. | β | 2020 | β |
| The genetic architecture of sporadic and multiple consecutive miscarriage. | Laisk T et al. | β | 2020 | β |
| The relationship between blood metabolites of the tryptophan pathway and kidney function: a bidirectional Mendelian randomization analysis. | Cheng Y et al. | β | 2020 | β |
| Understanding the nature of association between anxiety phenotypes and anorexia nervosa: a triangulation approach. | Lloyd EC et al. | β | 2020 | β |
| Using Mendelian randomization to understand and develop treatments for neurodegenerative disease. | Storm CS et al. | β | 2020 | β |
| A Bayesian approach to Mendelian randomisation with dependent instruments. | Shapland CY et al. | β | 2019 | β |
| Age at menarche and epithelial ovarian cancer risk: A meta-analysisΒ and Mendelian randomization study. | Yang H et al. | β | 2019 | β |
| Alcohol intake and risk of rheumatoid arthritis: aΒ Mendelian randomization study. | Bae SC et al. | β | 2019 | β |
| Alcohol intake and risk of systemic lupus erythematosus: a Mendelian randomization study. | Bae SC et al. | β | 2019 | β |
| Appraising the causal relevance of DNA methylation for risk of lung cancer. | Battram T et al. | β | 2019 | β |
| Assessing the robustness of sisVIVE in a Mendelian randomization study to estimate the causal effect of body mass index on income using multiple SNPs from understanding society. | Bao Y et al. | β | 2019 | β |
| Autoimmune Diseases and Lung Cancer: A Mendelian Randomization Study. | Zhou H et al. | β | 2019 | β |
| Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndrome. | Brower MA et al. | β | 2019 | β |
| Causal association between body mass index and risk of rheumatoid arthritis: A Mendelian randomization study. | Bae SC et al. | β | 2019 | β |
| Causal association between rheumatoid arthritis and aΒ decreased risk of Alzheimer's disease : AΒ Mendelian randomization study. | Bae SC et al. | β | 2019 | β |
| Causal association between smoking behavior and the decreased risk of osteoarthritis: aΒ Mendelian randomization. | Lee YH | β | 2019 | β |
| Circulating antioxidants and Alzheimer disease prevention: a Mendelian randomization study. | Williams DM et al. | β | 2019 | β |
| Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study. | Adams CD et al. | β | 2019 | β |
| Deciphering the Biological Mechanisms Underlying the Genome-Wide Associations between Computerized Device Use and Psychiatric Disorders. | Wendt FR et al. | β | 2019 | β |
| Docosapentaenoic acid and lung cancer risk: A Mendelian randomization study. | Liu J et al. | β | 2019 | β |
| Education and lung cancer: a Mendelian randomization study. | Zhou H et al. | β | 2019 | β |
| Education protects against coronary heart disease and stroke independently of cognitive function: evidence from Mendelian randomization. | Gill D et al. | β | 2019 | β |
| Effect of Genetically Low 25-Hydroxyvitamin D on Mortality Risk: Mendelian Randomization Analysis in 3 Large European Cohorts. | Aspelund T et al. | β | 2019 | β |
| Effects of blood lead on coronary artery disease and its risk factors: a Mendelian Randomization study. | Schooling CM et al. | β | 2019 | β |
| Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization. | Evans DM et al. | β | 2019 | β |
| Evaluating causal associations between chronotype and fatty acids and between fatty acids and type 2 diabetes: A Mendelian randomization study. | Adams CD et al. | β | 2019 | β |
| Examining the causal role of leptin in bone mineral density: A Mendelian randomization study. | Meng XH et al. | β | 2019 | β |
| Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration. | Wilman HR et al. | β | 2019 | β |
| Gout and the risk of Alzheimer's disease: A Mendelian randomization study. | Lee YH | β | 2019 | β |
| Guidelines for performing Mendelian randomization investigations: update for summer 2023. | Burgess S et al. | β | 2019 | β |
| Implementing MR-PRESSO and GCTA-GSMR for pleiotropy assessment in Mendelian randomization studies from a practitioner's perspective. | Ong JS et al. | β | 2019 | β |
| Investigating the effects of lycopene and green tea on the metabolome of men at risk of prostate cancer: The ProDiet randomised controlled trial. | Beynon RA et al. | β | 2019 | β |
| Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. | Warrington NM et al. | β | 2019 | β |
| Mendelian randomisation and the goal of inferring causation from observational studies in the vision sciences. | Plotnikov D et al. | β | 2019 | β |
| Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. | Porcu E et al. | β | 2019 | β |
| Meta-analysis and Mendelian randomization: A review. | Bowden J et al. | β | 2019 | β |
| Mineral Nutrition and the Risk of Chronic Diseases: A Mendelian Randomization Study. | Cheng WW et al. | β | 2019 | β |
| Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health. | Davies NM et al. | β | 2019 | β |
| No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma: A Mendelian Randomization Study. | Dong J et al. | β | 2019 | β |
| Potential causal associations of serum 25-hydroxyvitamin D with lipids: a Mendelian randomization approach of the HUNT study. | Mai XM et al. | β | 2019 | β |
| Probabilistic fine-mapping of transcriptome-wide association studies. | Mancuso N et al. | β | 2019 | β |
| Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies. | Morris AP et al. | β | 2019 | β |
| Uric acid level, gout and bone mineral density: A Mendelian randomization study. | Lee YH et al. | β | 2019 | β |
| Within family Mendelian randomization studies. | Davies NM et al. | β | 2019 | β |
| Are serum concentrations of vitamin B-12 causally related to cardiometabolic risk factors and disease? A Mendelian randomization study. | Moen GH et al. | β | 2018 | β |
| Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study. | Trajanoska K et al. | β | 2018 | β |
| Associations of Circulating Protein Levels With Lipid Fractions in the General Population. | Figarska SM et al. | β | 2018 | β |
| Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis. | Yarmolinsky J et al. | β | 2018 | β |
| Coffee consumption and the risk of rheumatoid arthritis and systemic lupus erythematosus: a Mendelian randomization study. | Bae SC et al. | β | 2018 | β |
| Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study. | He Y et al. | β | 2018 | β |
| Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study. | Bell JA et al. | β | 2018 | β |
| Investigating the possible causal association of coffee consumption with osteoarthritis risk using a Mendelian randomization analysis. | Lee YH | β | 2018 | β |
| Mendelian randomization does not support serum calcium in prostate cancer risk. | Yarmolinsky J et al. | β | 2018 | β |
| Reassessing the Association between Circulating Vitamin D and IGFBP-3: Observational and Mendelian Randomization Estimates from Independent Sources. | Tan VY et al. | β | 2018 | β |
| Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease. | Richardson TG et al. | β | 2018 | β |
| Using genetic data to strengthen causal inference in observational research. | Pingault JB et al. | β | 2018 | β |