Maturation of the adolescent brain.
- Authors
- Arain, Mariam; Haque, Maliha; Johal, Lina; Mathur, Puja; Nel, Wynand; Rais, Afsha; Sandhu, Ranbir; Sharma, Sushil
- Year
- 2013
- Journal
- Neuropsychiatric disease and treatment
- PMID
- 23579318
- DOI
- 10.2147/NDT.S39776
- PMCID
- PMC3621648
Adolescence is the developmental epoch during which children become adults - intellectually, physically, hormonally, and socially. Adolescence is a tumultuous time, full of changes and transformations. The pubertal transition to adulthood involves both gonadal and behavioral maturation. Magnetic resonance imaging studies have discovered that myelinogenesis, required for proper insulation and efficient neurocybernetics, continues from childhood and the brain's region-specific neurocircuitry remains structurally and functionally vulnerable to impulsive sex, food, and sleep habits. The maturation of the adolescent brain is also influenced by heredity, environment, and sex hormones (estrogen, progesterone, and testosterone), which play a crucial role in myelination. Furthermore, glutamatergic neurotransmission predominates, whereas gamma-aminobutyric acid neurotransmission remains under construction, and this might be responsible for immature and impulsive behavior and neurobehavioral excitement during adolescent life. The adolescent population is highly vulnerable to driving under the influence of alcohol and social maladjustments due to an immature limbic system and prefrontal cortex. Synaptic plasticity and the release of neurotransmitters may also be influenced by environmental neurotoxins and drugs of abuse including cigarettes, caffeine, and alcohol during adolescence. Adolescents may become involved with offensive crimes, irresponsible behavior, unprotected sex, juvenile courts, or even prison. According to a report by the Centers for Disease Control and Prevention, the major cause of death among the teenage population is due to injury and violence related to sex and substance abuse. Prenatal neglect, cigarette smoking, and alcohol consumption may also significantly impact maturation of the adolescent brain. Pharmacological interventions to regulate adolescent behavior have been attempted with limited success. Since several factors, including age, sex, disease, nutritional status, and substance abuse have a significant impact on the maturation of the adolescent brain, we have highlighted the influence of these clinically significant and socially important aspects in this report.
Factors influencing adolescent brain maturation.Notes: Brain maturation is influenced by heredity and environment, prenatal and postnatal insult, nutritional status, sleep patterns, pharmacotherapy, and surgical interventions during early childhood. Furthermore, physical, mental, economical, and psychological stress; drug abuse (caffeine, nicotine, and ethanol); and sex hormones, including estrogen, progesterone, and testosterone influence the development and maturation of the adolescent brain. MRI studies have suggested that neurocircuitry and myelinogenesis remain under construction during adolescence because these events in the CNS depend on sex hormones that are specifically increased during puberty.Abbreviations: CNS, central nervous system; MRI, magnetic resonance imaging.
A diagram illustrating various stages of human brain development.Notes: Several neurobehavioral, morphological, neurochemical, and pharmacological evidences suggest that the brain remains under construction during adolescence.1,2,3,7,12,21,22,23,25,42 Tubulinogenesis, axonogenesis, and synaptogenesis may be accomplished during prenatal and immediate postnatal life, yet myelinogenesis remains active during adolescent life. Furthermore, glutamatergic neurotransmission is accomplished during prenatal and immediate postnatal life, while GABAergic neurotransmission in the prefrontal cortex remains under construction. Delayed development of GABAergic neurotransmission among adolescents is implicated in neurobehavioral excitement and risk-taking behavior.Abbreviations: CT, computed tomography; GABAergic, gamma amino butyric acid ergic; MRI, magnetic resonance imaging.
A diagram illustrating the developmental regulation of executive functions by the prefrontal cortex, which remains under construction during adolescence.Notes: Several executive brain functions are governed by the prefrontal cortex, which remains in a state of active maturation during adolescence. These complex brain functions are regulated by the prefrontal cortex as illustrated in this figure (based on the original discoveries by Gedd and Steinberg).1,21β23,25 Due to immature functional areas in the prefrontal cortex, adolescent teens may take part in risk seeking behavior including unprotected sex, impaired driving, and drug addiction.
An algorithmic diagram illustrating the management of emotions and motivation by the limbic system in the adolescent brain.Notes: The nucleus accumbens and amygdala are the two most prominent parts of the central nervous system involved in riskier behavior and increased sex drive among teenage adolescents. The nucleus accumbens is highly sensitized to accomplish desirable goals. A decrease in dopamine in the nucleus accumbens is involved in increased vulnerability to drug addiction and risky decisions. Sex hormones (estrogen and testosterone) bind with their receptors to induce increased sex drive and emotional volatility and impulsivity. Due to an immature prefrontal cortex, adolescents also have an increased sex drive and problems in self-regulation as illustrated in this flow diagram.19,23,26,27,54
Leading cause of death among adolescents (10β24 years).Notes: Injury and violence are the two most common leading causes of death during adolescence. Out of 19 million adolescents (15β24 years) in the US that were diagnosed with HIV/AIDS, 39% admitted that they had unprotected sex. In addition to risky sex behavior, 30% of adolescents had been involved in motor vehicle accidents, with 41% of these linked to deaths; 12% committed suicide; and 15% were victims of homicide as illustrated in this figure (Steinberg 2004, Centers for Disease Control and Prevention).18Abbreviations: AIDS, acquired immune deficiency syndrome; HIV, human immunodeficiency virus; M, million; STD, sexually transmitted disease.
Effect of seafood on the maturation of the adolescent brain.Notes: MRI studies have provided evidence that in addition to the prefrontal cortex and limbic system, myelinogenesis and neurocircuitry remains under construction during adolescence.1,7,19,21 Myelinogenesis requires precursors such as polyunsaturated fatty acids, of which many seafoods are a rich source. Hence, consuming seafood may accelerate brain maturation in adolescents. However, malnutrition and substance abuse may inhibit maturation of the adolescent brain. (+) induction; (β) inhibition.
| Name | Type |
|---|---|
| abstract thinking local | phenotype |
| abstract thought local | phenotype |
| addiction | phenotype |
| adolescent behavior | phenotype |
| Adolescent brain development local | anatomy |
| adolescent brain maturation local | anatomy |
| Adolescent nervous system local | anatomy |
| adolescent population | cohort |
| adolescents | cohort |
| adolescent sexual behavior local | phenotype |
| Adrenocorticotropic hormones local | drug |
| adulthood | cohort |
| Adult role models local | cohort |
| adults | cohort |
| age 25 years local | phenotype |
| agents of infection local | drug |
| Ages 10-24 years local | cohort |
| aging | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| amygdala | anatomy |
| anesthetics | drug |
| anger | phenotype |
| anticonvulsant | drug |
| anxiety | phenotype |
| anxiety-like behavior | phenotype |
| anxiolytic compounds local | drug |
| arousal | phenotype |
| ascending dopaminergic system local | anatomy |
| attention deficit hyperactivity disorder | phenotype |
| Attitudes toward intimacy and independence local | phenotype |
| behavior | phenotype |
| behavioral immaturity local | phenotype |
| behavioral inhibition | phenotype |
| binge drinking | phenotype |
| brain | anatomy |
| brain activity | phenotype |
| Brain changes local | phenotype |
| brain development | phenotype |
| brain stem | anatomy |
| caffeine | drug |
| cannabis use | phenotype |
| central nervous system | anatomy |
| cerebellum | anatomy |
| chemotherapeutic compounds | drug |
| childhood | cohort |
| children | cohort |
| chronic stress | phenotype |
| cigarettes | phenotype |
| Circadian rhythms | phenotype |
| CNS complications local | phenotype |
| cocaine | phenotype |
| cognition | phenotype |
| Cognitive abnormalities | anatomy |
| cognitive analysis local | phenotype |
| Cognitive characteristics local | phenotype |
| cognitive development | phenotype |
| cognitive differences local | phenotype |
| cognitive processes | phenotype |
| cold cognition local | phenotype |
| community | cohort |
| computed tomography local | drug |
| concrete thinking local | phenotype |
| Copulatory behavior local | phenotype |
| corpus callosum | anatomy |
| correct behavior in social situations local | phenotype |
| Cortical circuitry breakdown local | phenotype |
| corticocortical functional connectivity local | anatomy |
| DAergic system local | anatomy |
| DAergic system local | drug |
| Dangerous behaviors local | phenotype |
| decision making | phenotype |
| Decision-making patterns local | phenotype |
| Delayed gratification local | phenotype |
| dependence | phenotype |
| depressive behavior | phenotype |
| Developmental dyslexia local | phenotype |
| Developmental Dyslexia local | phenotype |
| diet | drug |
| Disturbances in waking electroencephalography local | phenotype |
| dopamine | drug |
| Dopaminergic system | drug |
| drinking | phenotype |
| drug dependence | phenotype |
| drugs | drug |
| drug-seeking behavior | phenotype |
| early adulthood | cohort |
| eating behavior | phenotype |
| eating disorders | phenotype |
| Eating habits local | phenotype |
| elevated impulsivity local | phenotype |
| Emotion | phenotype |
| Emotional Volatility local | phenotype |
| emotion regulation | phenotype |
| Emotion-related brain regions local | anatomy |
| endocrine dysfunction local | phenotype |
| enhanced vulnerability to nicotine local | phenotype |
| environmental stress | phenotype |
| epilepsy | phenotype |
| estradiol | drug |
| estrogen | drug |
| ethanol consumption | phenotype |
| euphoria | phenotype |
| excitatory glutamatergic neurotransmission local | drug |
| executive brain functions local | phenotype |
| executive functioning | phenotype |
| fatty acids | drug |
| fear | phenotype |
| fetal alcohol syndrome | phenotype |
| Fish oils local | drug |
| Fish Oils local | drug |
| food intake | phenotype |
| frontal cortex | anatomy |
| GABA | phenotype |
| glutamate | drug |
| GnRH neurons local | anatomy |
| Gonadal maturation | phenotype |
| Gonadotropin-releasing hormone local | drug |
| good judgment local | phenotype |
| gray matter | anatomy |
| Guns local | drug |
| Gut Feeling Decision Making local | phenotype |
| Hemispheres local | anatomy |
| hippocampus | anatomy |
| homeostatic mechanisms local | anatomy |
| hot cognition local | phenotype |
| hypothalamic-pituitary-adrenal axis | anatomy |
| hypothalamicβpituitaryβadrenal axis | anatomy |
| hypothalamus | anatomy |
| Illicit substance abuse local | phenotype |
| immune function | phenotype |
| impaired driving local | phenotype |
| impulse control | phenotype |
| Impulsive decision making | phenotype |
| impulsive decisions local | phenotype |
| impulsivity | phenotype |
| infection | phenotype |
| intellectual performance issues local | phenotype |
| intelligence | phenotype |
| Intense emotions local | phenotype |
| Intense Mood Swings local | phenotype |
| learning | phenotype |
| learning and memory | phenotype |
| limbic regions | anatomy |
| limbic system | anatomy |
| Manicβdepressive psychosis local | phenotype |
| Mass media local | drug |
| Maternal Nutrition local | cohort |
| melatonin | drug |
| memory | phenotype |
| Memory storage local | phenotype |
| Mesolimbic brain regions local | anatomy |
| mesolimbic dopamine system | drug |
| mesolimbic system | anatomy |
| mind usage local | phenotype |
| mood disorders | phenotype |
| mood swings | phenotype |
| mortality | phenotype |
| Multimedia local | drug |
| myelin | phenotype |
| myelinogenesis local | phenotype |
| Myelinogenesis local | phenotype |
| neural reward systems local | anatomy |
| Neurocircuitry local | anatomy |
| Neurocircuitry local | phenotype |
| neurological disorders | phenotype |
| Neurophysiological changes local | phenotype |
| neuropsychiatric disorders | phenotype |
| neuropsychological impairment local | phenotype |
| Neurotoxic insult local | phenotype |
| nicotine | drug |
| nicotine dependence | phenotype |
| nicotine replacement therapy | drug |
| nicotine reward | phenotype |
| nicotine withdrawal | phenotype |
| nonreproductive behaviors local | phenotype |
| novelty seeking | phenotype |
| nucleus accumbens | anatomy |
| occipital cortex | anatomy |
| overnutrition local | phenotype |
| P3 wave local | phenotype |
| parenting local | drug |
| parietal cortex | anatomy |
| pediatric cancer survivors local | cohort |
| pediatric cancer treatment local | cohort |
| pediatric CNS local | anatomy |
| pediatric population local | cohort |
| physical characteristics | phenotype |
| physical development | phenotype |
| physical strength local | phenotype |
| physical tolerance local | phenotype |
| pleasure | phenotype |
| Postpubertal psychoses local | phenotype |
| prefrontal cortex | anatomy |
| pregnancy | phenotype |
| Premature sleep patterns local | phenotype |
| prenatal substance abuse local | drug |
| progesterone | drug |
| protein | drug |
| psychiatric disorders | phenotype |
| psychosis | phenotype |
| Psychosocial characteristics local | phenotype |
| Pubertal processes local | phenotype |
| puberty local | cohort |
| puberty | phenotype |
| Quickness to Anger local | phenotype |
| rats | cohort |
| reckless driving | phenotype |
| Reduction in the P3 wave local | phenotype |
| Reproductive behavior | phenotype |
| resilience | phenotype |
| risk assessment | phenotype |
| riskier decisions | phenotype |
| risk-taking behavior | phenotype |
| schizophrenia | phenotype |
| secondary malignancies local | phenotype |
| secondary sex characteristics | phenotype |
| Sedentary lifestyles local | phenotype |
| self-control | phenotype |
| self-regulation | phenotype |
| sensory dysfunction local | phenotype |
| serotonin | drug |
| sex | phenotype |
| sex differences | phenotype |
| sex drive | phenotype |
| sex hormones | drug |
| Sexual motivation local | phenotype |
| Sexual salience of sensory stimuli local | phenotype |
| sleep | phenotype |
| sleep-inducing compounds local | drug |
| Sleeping habits local | phenotype |
| sleep requirements local | phenotype |
| Sleepβwake cycle local | phenotype |
| slow-wave sleep | phenotype |
| social brain local | anatomy |
| Social brain local | anatomy |
| social cognition | phenotype |
| Socialβemotional development local | phenotype |
| social factors local | drug |
| Steroid hormones local | drug |
| stress | phenotype |
| stress hormones | drug |
| structural MRI | drug |
| subcortical brain areas local | anatomy |
| Subcortical dysfunction local | phenotype |
| subcortical functional connectivity local | anatomy |
| subcorticocortical functional connectivity local | anatomy |
| substance abuse | phenotype |
| synaptic plasticity | phenotype |
| teens | cohort |
| temporal lobe | anatomy |
| testosterone | drug |
| tobacco dependence | phenotype |
| toxic effects | phenotype |
| trauma | phenotype |
| undernutrition | phenotype |
| unprotected sex | phenotype |
| ventral tegmental area | anatomy |
| Waking electroencephalography local | phenotype |
| white matter | anatomy |
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