Genetic subtypes of unipolar primary depressive illness distinguished by hypothalamic-pituitary-adrenal axis activity.
paper
Cited
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- Authors
- Schlesser, M A; Winokur, G; Sherman, B M
- Year
- 1979
- Journal
- Lancet (London, England)
- PMID
- 85987
- DOI
- 10.1016/s0140-6736(79)91203-0
Serum-cortisol response to the 1 mg overnight dexamethasone suppression test was investigated in 86 patients with unipolar primary depressive illness and 80 non-depressed controls (45 with mania and 35 with schizophrenia). The depressed patients were assigned to one of three genetic subtypes according to the family psychiatric history. Resistance to suppression of serum-cortisol by dexamethasone was found in 37 of 86 (43%) depressives and none of the 80 controls. Non-suppression distinguished the three genetic subtypes of depression, being found in 23 of 28 (82%) patients with familial pure depressive disease (F.P.D.D.), 13 of 35 (37%) patients with sporadic depressive disease (S.D.D.), and 1 of 23 (4%) patients with depression spectrum disease (D.S.D.). The three genetic subtypes were further distinguished by the age of onset, with S.D.D. the oldest, and by the number of previous depressive episodes, with F.P.D.D. the most. Severity of depression did not separate the three subtypes. This is the first report of a distinct neuroendocrine abnormality which supports an objectively defined classification of unipolar primary depressive illness. It is suggested that unipolar primary depressive illness is three or more separate illnesses, each with a potentially distinctive mode of inheritance, pathophysiology, neurochemistry, clinical course, and treatment response.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Rostral anterior cingulate cortex volume correlates with depressed mood in normal healthy children. | Boes AD et al. | — | 2008 | → |
| The facets of melancholia. | Coryell W | — | 2007 | → |
| Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: diagnostic specificity and prognostic implications. | Coryell W et al. | — | 2005 | → |
| Is there a genetic relationship between alcoholism and depression? | Nurnberger JI et al. | — | 2002 | → |
| Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. | Nurnberger JI et al. | — | 2001 | → |
| Multiple HPA profiles in endogenous depression: effect of age and sex on cortisol and beta-endorphin. | Akil H et al. | — | 1993 | → |
| Age and the dexamethasone suppression test: results from a broad unselected patient population. | Keitner GI et al. | — | 1992 | → |
| Family history of psychiatric disorder and low self-confidence: predictors of depressive symptoms at 12-month follow-up. | Hughes DC et al. | — | 1992 | → |
| Serial dexamethasone suppression test in psychiatric inpatients. | Hwu HG et al. | — | 1990 | → |
| The assessment of abnormalities in hormonal responsiveness at multiple levels of the hypothalamic-pituitary-adrenocortical axis in depressive illness. | Amsterdam JD et al. | — | 1989 | → |
| Depressive states in 11 psychiatrically hospitalized preschoolers: investigation and review. | Doherty MB et al. | — | 1988 | → |
| Individual differences in plasma cortisol changes during mania and depression. | Joyce PR et al. | — | 1987 | → |
| The ACTH stimulation test before and after clinical recovery from depression. | Amsterdam JD et al. | — | 1987 | → |
| The dexamethasone suppression test in dementia. | Magni G et al. | — | 1987 | → |
| Relationships of the dexamethasone suppression test to clinical severity and degree of melancholia. | Kumar A et al. | — | 1986 | → |
| The dexamethasone suppression test in depressive and schizophrenic patients under controlled treatment conditions. | Möller HJ et al. | — | 1986 | → |
| Comparative dexamethasone suppression test measurements in bulimia, depression and normal controls. | Musisi S et al. | — | 1985 | → |
| Dexamethasone suppression test and the levels of serum growth hormone, plasma vasopressin and plasma homovanillic acid in depressed in- and outpatients. | Syvälahti E | — | 1985 | → |
| Failure to normalize the dexamethasone suppression test: association with length of illness. | Lenox RH et al. | — | 1985 | → |
| Lymphocyte glucocorticoid receptor binding in depressed patients with hypercortisolemia. | Schlechte JA et al. | — | 1985 | → |
| Persistent elevation of urinary free cortisol and loss of circannual periodicity in recovered depressive patients. A trait finding. | Kathol RG | — | 1985 | → |
| The dexamethasone suppression test in depressed retarded adults: preliminary findings. | Beckwith BE et al. | — | 1985 | → |
| The dexamethasone suppression test in depression. | Dam H et al. | — | 1985 | → |
| Clinical investigations into antidepressive mechanisms. II. Dexamethasone suppression test predicts response to nomifensine or amitriptyline. | Beckmann H et al. | — | 1984 | → |
| Depression in the geriatric population--implications for the dental practitioner. | Schmahl SR | — | 1984 | → |
| [Dexamethasone suppression test: a biologic marker of endogenous depression?]. | Berger M et al. | — | 1984 | → |
| Dexamethasone suppression test in depression: association with duration of illness. | Sashidharan SP et al. | — | 1984 | → |
| Identification of depression in children and adolescents: the role of the dexamethasone suppression test. | Klee SH et al. | — | 1984 | → |
| Mean 14.00-17.00 h plasma cortisol concentration and its relationship to the 1 mg-dexamethasone suppression response in depressives and controls. | Holsboer F et al. | — | 1984 | → |
| Outcomes on lithium treatment as a tool for genetic studies in affective disorders. | Smeraldi E et al. | — | 1984 | → |
| Postdexamethasone prolactin and cortisol: a biological state variable in depression. | Klein HE et al. | — | 1984 | → |
| Symptoms and subtypes of depression among adolescents distinguished by the dexamethasone suppression test: a preliminary report. | Alessi NE et al. | — | 1984 | → |
| The dexamethasone suppression test in normal control subjects: comparison of two assays and effect of age. | Rosenbaum AH et al. | — | 1984 | → |
| The implications of DSM-III personality disorders for patients with major depression. | Pfohl B et al. | — | 1984 | → |
| Biological classification of depressive illness. | Coppen A et al. | — | 1983 | → |
| Chrononeuroendocrine perspectives of ACTH and related peptides. | Falaschi P et al. | — | 1983 | → |
| Cortisol secretion and DST in affective disorders--methodological concerns. | Prabhu V et al. | — | 1983 | → |
| Depression spectrum disease or character spectrum disorder? A clinical study of major depressives with familial alcoholism or sociopathy. | Van Valkenburg C et al. | — | 1983 | → |
| Dexamethasone suppression test response in major depression: stability across hospitalizations. | Coryell W et al. | — | 1983 | → |
| Regulation of ACTH and cortisol in depression. | Reus VI et al. | — | 1983 | → |
| Response to dexamethasone in psychotic depression. | Caroff S et al. | — | 1983 | → |
| Serial dexamethasone suppression test results during antidepressant therapy: relationship to diagnosis and clinical change. | Coryell W et al. | — | 1983 | → |
| The dexamethasone suppression test. | Leckman JF | — | 1983 | → |
| The dexamethasone suppression test in adolescent depression. | Hsu LK et al. | — | 1983 | → |
| The effect of chlormethiazole on serum cortisol concentrations in chronic alcoholics. | Majumdar SK | — | 1983 | → |
| The familial classification of primary unipolar depression: biological validation of distinct subtypes. | Lewis DA et al. | — | 1983 | → |
| The thyrotropin-releasing hormone and dexamethasone suppression tests in the familial classification of depression. | Fleming JE et al. | — | 1983 | → |
| Toward a biochemical classification of depressive disorders, VII: urinary free cortisol and urinary MHPG in depressions. | Rosenbaum AH et al. | — | 1983 | → |
| Central nervous system and peripheral effects of ACTH, MSH, and related neuropeptides. | Beckwith BE et al. | — | 1982 | → |
| Clinical applications of psychiatric genetics. | Targum SD et al. | — | 1982 | → |
| Diagnosis of depression in a general medical practice: observations on "lack of pizzazz," the "blahs," and other complaints. | Burnum JF | — | 1982 | → |
| Hypothalamic-pituitary-adrenal axis abnormality and ECT response. | Coryell W | — | 1982 | → |
| Patterns of depression reflected in pituitary - thyroid and pituitary - adrenal endocrine changes. | Agren H et al. | — | 1982 | → |
| Pituitary-adrenal regulation over multiple depressive episodes. | Brown WA et al. | — | 1982 | → |
| Subtypes of unipolar depression distinguished by the dexamethasone suppression test. | Targum SD et al. | — | 1982 | → |
| The significance of biological factors in the diagnosis of depressions: II hormonal variables. | van Praag HM | — | 1982 | → |
| The use of the dexamethasone suppression test in the differential diagnosis of catatonic stupor. | Bloodworth RC | — | 1982 | → |
| Cortisol secretion and dexamethasone response in depression. | Asnis GM et al. | — | 1981 | → |
| Current antidepressant drugs: their clinical use. | Hollister LE | — | 1981 | → |
| Depression: diagnosis and treatment with tricyclic antidepressants. | Gold MS et al. | — | 1981 | → |
| Dexamethasone suppression test and selection of antidepressant medications. | Greden JF et al. | — | 1981 | → |
| Dextroamphetamine infusions in normals result in correlated increases of plasma beta-endorphin and cortisol immunoreactivity. | Cohen MR et al. | — | 1981 | → |
| Gender differences in bipolar affective disorder. | Taylor MA et al. | — | 1981 | → |
| Pituitary-adrenal disinhibition in depression: marker of a subtype with characteristic clinical features and response to treatment? | Brown WA et al. | — | 1981 | → |
| Psychomotor function in affective disorders: an overview of new monitoring techniques. | Greden JF et al. | — | 1981 | → |
| The classification of affective disorders: a synthesis of old and new concepts. | Roth RM et al. | — | 1981 | → |
| The dexamethasone suppression test: clinical applications. | Brown WA | — | 1981 | → |
| Urinary free cortisol and clinical classification of depressive illness. | Milln P et al. | — | 1981 | → |
| A theory of convulsive therapy in endogenous depression: significance of hypothalamic functions. | Fink M et al. | — | 1980 | → |
| Biological component of the NIMH clinical research branch collaborative program on the psychobiology of depression: I. Background and theoretical considerations. | Maas JW et al. | — | 1980 | → |
| Biology of manic-melancholic disorders. | Rafaelsen OJ | — | 1980 | → |
| Diagnosis of endogenous depression. Comparison of clinical, research and neuroendocrine criteria. | Carroll BJ et al. | — | 1980 | → |
| Is there a common genetic factor in bipolar and unipolar affective disorder? | Winokur G | — | 1980 | → |
| Monoamine metabolites in cerebrospinal fluid of depressive subgroups. | Rosenthal NE et al. | — | 1980 | → |
| Neuroendocrine dysfunction in genetic subtypes of primary unipolar depression. | Carroll BJ et al. | — | 1980 | → |
| Neuroendocrine studies in affective disorders. Part 1. Plasma prolactin response to thyrotropin-releasing hormone in affective disorders: effect of ECT. | Coppen A et al. | — | 1980 | → |
| Neuroendocrine studies in affective disorders. Part 2. Plasma thyroid-stimulating hormone response to thyrotropin-releasing hormone in affective disorders: effect of ECT. | Coppen A et al. | — | 1980 | → |
| Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illness. | Checkley SA | — | 1980 | → |
| Neuroendocrinology and ECT: a review of recent developments. | Fink M | — | 1980 | → |
| Rapidly evolving anoxia after inhalation of polluted water. | Servadio G et al. | — | 1980 | → |
| Reassessing the bipolar-unipolar dichotomy. | Taylor MA et al. | — | 1980 | → |
| The medical model-why psychiatry is a branch of medicine. | Joyce PR | — | 1980 | → |
| Who responds to amitriptyline? | Milln P et al. | — | 1980 | → |
| Hyperacitivity of hypothalamic-pituitary-adrenal axis in endogenous depression. | Langer G et al. | — | 1979 | → |
| The safest place of birth. | Senn SJ | — | 1979 | → |