Is there a genetic relationship between alcoholism and depression?
- Authors
- Nurnberger, John I; Foroud, Tatiana; Flury, Leah; Meyer, Eric T; Wiegand, Ryan
- Year
- 2002
- Journal
- Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism
- PMID
- 12875052
- PMCID
- PMC6683839
The Collaborative Study on the Genetics of Alcoholism (COGA) seeks to identify genes contributing to alcoholism and related traits (i.e., phenotypes), including depression. Among alcoholic subjects the COGA study found an increased prevalence of depressive syndrome (i.e., depression that may or may not occur in conjunction with increased drinking). This combination of alcoholism and depression tends to run in families. Comorbid alcoholism and depression occurred substantially more often in first-degree relatives of COGA participants with alcoholism than in relatives of control participants. Based on these data, COGA investigators defined three phenotypes--"alcoholism," "alcoholism and depression," and "alcoholism or depression"--and analyzed whether these phenotypes were linked to specific chromosomal regions. These analyses found that the "alcoholism or depression" phenotype showed significant evidence for genetic linkage to an area on chromosome 1. This suggests that a gene or genes on chromosome 1 may predispose some people to alcoholism and others to depression (which may be alcohol induced).
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| Novel characterization of the multivariate genetic architecture of internalizing psychopathology and alcohol use. | Colbert SMC et al. | — | 2021 | → |
| Stress vulnerability promotes an alcohol-prone phenotype in a preclinical model of sustained depression. | Riga D et al. | — | 2020 | → |
| Reliability and validity of an internalizing symptom scale based on the adolescent and adult Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). | Acion L et al. | — | 2019 | → |
| Shared genetic etiology between alcohol dependence and major depressive disorder. | Foo JC et al. | — | 2018 | → |
| The developmental psychopathology of alcohol use and alcohol disorders: research achievements and future directions. | Chassin L et al. | — | 2013 | → |
| Genome-wide association study of comorbid depressive syndrome and alcohol dependence. | Edwards AC et al. | — | 2012 | → |
| An internalizing pathway to alcohol use and disorder. | Hussong AM et al. | — | 2011 | → |
| Associations between first use of substances and change in internalizing symptoms among girls: differences by symptom trajectory and substance use type. | Marmorstein NR et al. | — | 2010 | → |
| Glial and glutamatergic markers in depression, alcoholism, and their comorbidity. | Miguel-Hidalgo JJ et al. | — | 2010 | → |
| Longitudinal associations between depression and substance dependence from adolescence through early adulthood. | Marmorstein NR et al. | — | 2010 | → |
| Binge drinking and depressive symptoms: a 5-year population-based cohort study. | Paljärvi T et al. | — | 2009 | → |
| Longitudinal associations between alcohol problems and depressive symptoms: early adolescence through early adulthood. | Marmorstein NR | — | 2009 | → |
| Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients. | Joe KH et al. | — | 2008 | → |
| triADD: the risk for alcohol abuse, depression, and diabetes multimorbidity in the American Indian and Alaska Native populations. | Tann SS et al. | — | 2007 | → |
| Alcohol consumption alters dopamine transporter sites in Wistar-Kyoto rat brain. | Jiao X et al. | — | 2006 | → |
| Correlation of liver dysfunction biological markers to the mood status of alcohol-dependent individuals. | Liappas IA et al. | — | 2006 | → |
| Depression syndromes with risk of alcohol dependence in adulthood: a latent class analysis. | Crum RM et al. | — | 2005 | → |
| Genetic influences in emotional dysfunction and alcoholism-related brain damage. | Oscar-Berman M et al. | — | 2005 | → |
| Two types of classification for male opioid dependence: identification of an opioid addict with depressive features. | Modestin J et al. | — | 2005 | → |