The results pointed to an area of interest on chromosome 1 for the AorD phenotype (Nurnberger et al. 2001). Increased allele sharing was seen near two markers called D1S1648 and D1S1588 between 100 and 110 centi-Morgan (cM)1 from the origin. This increased sharing was observed in the initial data set, to a lesser extent in the replication data set, and was still evident when the two data sets were combined. Overall, the analyses found evidence for genetic linkage over a relatively large portion of chromosome 1 (i.e., 60 cM). (For a summary of other linkage results from these data sets, including results for the AAD and DEP phenotypes, see Nurnberger and colleagues 2001; see also the articles in this issue by Bierut and colleagues, pp. 208–213 and by Edenberg, pp. 214–218.)
