The same portion of chromosome 1 that exhibited linkage with the AorD phenotype also has shown suggestive linkage with the ALC phenotype (Reich et al. 1998). Analysis of all possible sibling pairs with the ALC phenotype in the initial data set identified a region near a marker called D1S1675. In sibling pairs with the ALC phenotype, allele sharing in that area was similar to the allele sharing observed in sibling pairs with the AorD phenotype. In these families, the same genetic characteristics may predispose some people to depression and others to alcoholism.
