Brain oscillations as biomarkers in neuropsychiatric disorders: following an interactive panel discussion and synopsis.
- Authors
- Yener, GΓΆrsev G; BaΕar, Erol
- Year
- 2013
- Journal
- Supplements to Clinical neurophysiology
- PMID
- 24053048
- DOI
- 10.1016/b978-0-7020-5307-8.00016-8
This survey covers the potential use of neurophysiological changes as a biomarker in four neuropsychiatric diseases (attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), bipolar disorder (BD), and schizophrenia (SZ)). Great developments have been made in the search of biomarkers in these disorders, especially in AD. Nevertheless, there is a tremendous need to develop an efficient, low-cost, potentially portable, non-invasive biomarker in the diagnosis, course, or treatment of the above-mentioned disorders. Electrophysiological methods would provide a tool that would reflect functional brain dynamic changes within milliseconds and also may be used as an ensemble of biomarkers that is greatly needed in the evaluation of cognitive changes seen in these disorders. The strategies for measuring cognitive changes include spontaneous electroencephalography (EEG), sensory evoked oscillation (SEO), and event-related oscillations (ERO). Further selective connectivity deficit in sensory or cognitive networks is reflected by coherence measurements. Possible candidate biomarkers discussed in an interactive panel can be summarized as follows: for ADHD: (a) elevation of delta and theta, (b) diminished alpha and beta responses in spontaneous EEG; for SZ: (a) decrease of ERO gamma responses, (b) decreased ERO in all other frequency ranges, (c) invariant ERO gamma response in relation to working memory demand; for euthymic BD: (a) decreased event-related gamma coherence, (b) decreased alpha in ERO and in spontaneous EEG; for manic BD: (a) lower alpha and higher beta in ERO, (b) decreased event-related gamma coherence, (c) lower alpha and beta in ERO after valproate; and for AD: (a) decreased alpha and beta, and increased theta and delta in spontaneous EEG, (b) hyperexcitability of motor cortices as shown by transcortical magnetic stimulation, (c) hyperexcitability of visual sensory cortex as indicated by increased SEO theta responses, (d) lower delta ERO, (e) lower delta, theta, and alpha event-related coherence, (f) higher theta synchrony and higher alpha event-related coherence in cholinergically treated AD subjects. In further research in the search for biomarkers, multimodal methods should be introduced to electrophysiology for validation purposes. Also, providing the protocols for standardization and harmonization of user-friendly acquisition or analysis methods that would be applied in larger cohort populations should be used to incorporate these electrophysiologic methods into the clinical criteria. In an extension to conventional anatomical, biochemical and brain imaging biomarkers, the use of neurophysiologic markers may lead to new applications for functional interpretrations and also the possibility to monitor treatments tailored for individuals.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
| Brain oscillations in neuropsychiatric disease. | 2013 | 24174901 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Gestational Chlorpyrifos Exposure Imparts Lasting Alterations to the Rat Somatosensory Cortex | Koenig JA et al. | β | 2025 | β |
| Gestational Chlorpyrifos Exposure Imparts Lasting Alterations to the Rat Somatosensory Cortex. | Koenig JA et al. | β | 2025 | β |
| Virtual reality based audio visual brainwave entrainment to improve learning in children with attention deficit hyperactive disorder. | Mandapati M et al. | β | 2025 | β |
| Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models. | NegrΓ³n-Oyarzo I et al. | β | 2024 | β |
| Effects of the mGlu2/3 receptor agonist LY379268 on two models of disturbed auditory evoked brain oscillations in mice. | Dormann OD et al. | β | 2023 | β |
| Gender-Specific Interactions in a Visual Object Recognition Task in Persons with Opioid Use Disorder. | Petrie J et al. | β | 2023 | β |
| Neural Oscillation Disorder in the Hippocampal CA1 Region of Different Alzheimer's Disease Mice. | Yuan W et al. | β | 2023 | β |
| Would frontal midline theta indicate cognitive changes induced by non-invasive brain stimulation? A mini review. | Nakamura-Palacios EM et al. | β | 2023 | β |
| Altered Connectivity of the Frontoparietal Network During Attention Processing in Prolactinomas. | Cao C et al. | β | 2021 | β |
| The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala-Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders. | Vila-Merkle H et al. | β | 2021 | β |
| Analysis of KCNH2 and CACNA1C schizophrenia risk genes on EEG functional network modulation during an auditory odd-ball task. | Lubeiro A et al. | β | 2020 | β |
| Differential effects of traxoprodil and S-ketamine on quantitative EEG and auditory event-related potentials as translational biomarkers in preclinical trials in rats and mice. | Raith H et al. | β | 2020 | β |
| Envelope Following Response to 440 Hz Carrier Chirp-Modulated Tones Show Clinically Relevant Changes in Schizophrenia. | Griskova-Bulanova I et al. | β | 2020 | β |
| Suppression of Parvalbumin Interneuron Activity in the Prefrontal Cortex Recapitulates Features of Impaired Excitatory/Inhibitory Balance and Sensory Processing in Schizophrenia. | Toader O et al. | β | 2020 | β |
| New Horizons in Early Dementia Diagnosis: Can Cerebellar Stimulation Untangle the Knot? | Naro A et al. | β | 2019 | β |
| No evidence of associations between ADHD and event-related brain potentials from a continuous performance task in a population-based sample of adolescent twins. | Lau-Zhu A et al. | β | 2019 | β |
| Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology. | Stampanoni Bassi M et al. | β | 2019 | β |
| The Modulation of Gamma Oscillations by Methamphetamine in Rat Hippocampal Slices. | Li Y et al. | β | 2019 | β |
| A minimally invasive neurostimulation method for controlling abnormal synchronisation in the neuronal activity. | Asllani M et al. | β | 2018 | β |
| A within-subject consideration of the psychotic spectrum disorder concept in a patient in remission associated with cortical gray matter recovery. | Meltzer HY et al. | β | 2018 | β |
| Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late "P300-Like" Event-Related Potential in Rats. | Ahnaou A et al. | β | 2018 | β |
| Electroencephalographic delta/alpha frequency activity differentiates psychotic disorders: a study of schizophrenia, bipolar disorder and methamphetamine-induced psychotic disorder. | Howells FM et al. | β | 2018 | β |
| Frontal Alpha Asymmetry and Theta Oscillations Associated With Information Sharing Intention. | Fischer NL et al. | β | 2018 | β |
| Stimulus dependent neural oscillatory patterns show reliable statistical identification of autism spectrum disorder in a face perceptual decision task. | Castelhano J et al. | β | 2018 | β |
| Acute low-level alcohol consumption reduces phase locking of event-related oscillations in rodents. | Amodeo LR et al. | β | 2017 | β |
| Alterations of Intrinsic Brain Connectivity Patterns in Depression and Bipolar Disorders: A Critical Assessment of Magnetoencephalography-Based Evidence. | Alamian G et al. | β | 2017 | β |
| Functional EEG network analysis in schizophrenia: Evidence of larger segregation and deficit of modulation. | Gomez-Pilar J et al. | β | 2017 | β |
| Machine-based classification of ADHD and nonADHD participants using time/frequency features of event-related neuroelectric activity. | Γztoprak H et al. | β | 2017 | β |
| AΞ²1-42-induced dysfunction in synchronized gamma oscillation during working memory. | Bai W et al. | β | 2016 | β |
| Best method for analysis of brain oscillations in healthy subjects and neuropsychiatric diseases. | BaΕar E et al. | β | 2016 | β |
| Evidence for genetic regulation of the human parieto-occipital 10-Hz rhythmic activity. | Salmela E et al. | β | 2016 | β |
| Impaired theta-gamma coupling in APP-deficient mice. | Zhang X et al. | β | 2016 | β |
| Promising Role of Neuromodulation in Predicting the Progression of Mild Cognitive Impairment to Dementia. | Naro A et al. | β | 2016 | β |
| What does the broken brain say to the neuroscientist? Oscillations and connectivity in schizophrenia, Alzheimer's disease, and bipolar disorder. | BaΕar E et al. | β | 2016 | β |
| Advances in Electrophysiological Research. | Kamarajan C et al. | β | 2015 | β |
| Heightened Delta Power during Slow-Wave-Sleep in Patients with Rett Syndrome Associated with Poor Sleep Efficiency. | Ammanuel S et al. | β | 2015 | β |
| Pharmaco-EEG Studies in Animals: An Overview of Contemporary Translational Applications. | Drinkenburg WH et al. | β | 2015 | β |
| Biomarkers in the diagnosis of ADHD--promising directions. | Faraone SV et al. | β | 2014 | β |
| Cholinergic modulation of event-related oscillations (ERO). | Sanchez-Alavez M et al. | β | 2014 | β |
| Non-invasive detection of high gamma band activity during motor imagery. | Smith MM et al. | β | 2014 | β |
| Patients with mild cognitive impairment display reduced auditory event-related delta oscillatory responses. | Kurt P et al. | β | 2014 | β |
| The visual cognitive network, but not the visual sensory network, is affected in amnestic mild cognitive impairment: a study of brain oscillatory responses. | Yener GG et al. | β | 2014 | β |
| Brain oscillations in neuropsychiatric disease. | BaΕar E | β | 2013 | β |
| Brain's alpha, beta, gamma, delta, and theta oscillations in neuropsychiatric diseases: proposal for biomarker strategies. | BaΕar E et al. | β | 2013 | β |