Further Analyses of Genetic Association Between GRM8 and Alcohol Dependence Symptoms Among Young Adults.
- Authors
- Long, Elizabeth C; Aliev, Fazil; Wang, Jen-Chyong; Edenberg, Howard J; Nurnberger, John; Hesselbrock, Victor; Porjesz, Bernice; Dick, Danielle M
- Year
- 2015
- Journal
- Journal of studies on alcohol and drugs
- PMID
- 25978827
- DOI
- 10.15288/jsad.2015.76.414
- PMCID
- PMC4440299
OBJECTIVE: The gene GRM8, a metabotropic glutamate receptor, has emerged as a gene of interest for its possible role in the development of alcohol dependence, with evidence of association with an electrophysiological endophenotype and level of response to alcohol as well as suggestive evidence of association with alcohol dependence. METHOD: The present study further investigated the association between GRM8 and alcohol dependence symptom counts among young adults using a new sample of individuals collected as part of the prospective sample (ages 18-26 years; N = 842) from the Collaborative Study on the Genetics of Alcoholism (COGA). RESULTS: Two single-nucleotide polymorphisms were significantly associated with alcohol dependence in European Americans using the Nyholt corrected p value of .007: rs886003 (β = -.212, p = .0002) and rs17862325 (β = -.234, p < .0001), but not in African Americans, likely because of the lower power to detect association in this group. CONCLUSIONS: These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. | 2016 | 26809998 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory Transmission and Sensorimotor Activity. | Nabit BP et al. | — | 2024 | → |
| Loss-of-Function Models of the Metabotropic Glutamate Receptor Genes <i>Grm8a</i> and <i>Grm8b</i> Display Distinct Behavioral Phenotypes in Zebrafish Larvae (<i>Danio rerio</i>). | Lüffe TM et al. | — | 2022 | → |
| GRM8 genotype is associated with externalizing disorders and greater inter-trial variability in brain activation during a response inhibition task. | Bauer LO et al. | — | 2020 | → |
| Pharmacogenetics of drug dependence: Polymorphisms of genes involved in glutamate neurotransmission. | Nudmamud-Thanoi S et al. | — | 2020 | → |
| Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence. | Alasmari F et al. | — | 2018 | → |
| A 7q31.33q32.1 microdeletion including <i>LRRC4</i> and <i>GRM8</i> is associated with severe intellectual disability and characteristics of autism. | Sangu N et al. | — | 2017 | → |
| Effects of alcohol on c-Myc protein in the brain. | Akinyeke T et al. | — | 2017 | → |
| Association study of DRD2 A2/A1, DRD3 Ser9Gly, DβH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A polymorphisms with alcohol dependence. | Ragia G et al. | — | 2016 | → |
| Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings. | Bell RL et al. | — | 2016 | → |