Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review.
paper
Primary
Public
- Authors
- Edenberg, Howard J; McClintick, Jeanette N
- Year
- 2018
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 30320893
- DOI
- 10.1111/acer.13904
- PMCID
- PMC6286250
Alcohol use disorders (AUDs) are complex traits, meaning that variations in many genes contribute to the risk, as does the environment. Although the total genetic contribution to risk is substantial, most individual variations make only very small contributions. By far the strongest contributors are functional variations in 2 genes involved in alcohol (ethanol [EtOH]) metabolism. A functional variant in alcohol dehydrogenase 1B (ADH1B) is protective in people of European and Asian descent, and a different functional variant in the same gene is protective in those of African descent. A strongly protective variant in aldehyde dehydrogenase 2 (ALDH2) is essentially only found in Asians. This highlights the need to study a wide range of populations. The likely mechanism of protection against heavy drinking and AUDs in both cases is alteration in the rate of metabolism of EtOH that at least transiently elevates acetaldehyde. Other ADH and ALDH variants, including functional variations in ADH1C, have also been implicated in affecting drinking behavior and risk for alcoholism. The pattern of linkage disequilibrium in the ADH region and the differences among populations complicate analyses, particularly of regulatory variants. This critical review focuses upon the ADH and ALDH genes as they affect AUDs.
Primary pathway of alcohol metabolism.The oxidation of alcohol to acetaldehyde is reversible in vitro, but in vivo the overall reaction goes strongly toward acetate due to the activity of ALDH2. The ADH and ALDH enzymes that carry out most of the metabolism are shown.
Expression of ADH mRNA in selected tissues.Data are in median transcripts per million transcripts (tpm), from GTEx version 7 (gtexportal.org, exported 15 April 2018) (GTEx Consortium, 2013). ADH genes are shown in numerical order, left to right, within each tissue. Inset shows enlarged image of stomach, brain (maximum tpm across all brain tissues) and whole blood.
ADH region of chromosome 4.ADH genes are arranged head-to-tail along chromosome 4, and transcribed in the opposite direction. Numbers below the line are distances between genes, in kb.
Expression of key ALDH RNAs in selected tissues.Data are median tpm, from GTEx version 7 (exported 15 April 2018) (GTEx Consortium, 2013).
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|---|---|---|
| 60 | Aldehyde dehydrogenase enzymes β ALDH1B1 | Two missense variants in ALDH1B1 are predicted to be damaging (Way et al., 2017). The Ala86Valβ¦ |
| 61 | Aldehyde dehydrogenase enzymes β ALDH1A1 | ALDH1A1 is a cytosolic enzyme that has a low affinity for acetaldehyde (Table 3). It is expressed atβ¦ |
| 62 | Aldehyde dehydrogenase enzymes β ALDH1A1 | There are several low frequency variants of ALDH1A1 that have been nominally associated withβ¦ |
| 63 | Aldehyde dehydrogenase enzymes β ALDH results to date | There is overwhelming evidence, both biochemical and genetic, that ALDH2*2 reduces alcoholβ¦ |
| 64 | Conclusions | The coding variants ADH1B*2, ADH1B*3, ADH1C*1 and ALDH2*2 all provide some protection against⦠|
| 65 | Conclusions | The evidence for effects of other ADH and ALDH genes is much weaker. Regulatory variants and other⦠|
| 66 | Conclusions | Beyond the genes encoding these metabolic enzymes, there are probably at least hundreds to thousands⦠|
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61β67 of 67
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects. | Hart SFM et al. | β | 2026 | β |
| Genome-wide meta-analyses of cross substance use disorders in diverse populations. | Lai D et al. | β | 2026 | β |
| Long-term impact of embryonic ethanol exposure on gene expression and executive functions in zebrafish. | Lima Filho RO et al. | β | 2026 | β |
| Rapid and simple lateral flow detection for ADH1B and ALDH2 genotyping: PCR-restriction digestion-adapter ligation-lateral flow (PRALL) assay. | Shirasu N et al. | β | 2026 | β |
| Activation of hepatic alcohol metabolism by enzymatic porcine placenta hydrolysate in rats. | Shin J et al. | β | 2025 | β |
| Addiction Susceptibility: Genetic Factors, Personality Traits, and Epigenetic Interactions with the Gut Microbiome. | Borrego-Ruiz A et al. | β | 2025 | β |
| Alcohol-clozapine synergism triggering rhabdomyolysis at subtoxic levels: a case report and literature review. | Zhou W et al. | β | 2025 | β |
| Alcohol-Metabolizing Enzymes, Liver Diseases and Cancer. | Liu T et al. | β | 2025 | β |
| Comparative Evaluation of Combined Denoising and Resolution Enhancement Algorithms for Intravital Two-Photon Imaging of Organs. | Bohlooli Darian S et al. | β | 2025 | β |
| Computational identification of potential bioactive compounds from Triphala against alcoholic liver injury by targeting alcohol dehydrogenase. | Banjan B et al. | β | 2025 | β |
| Deciphering the Role of Oroxylin A in Liver Fibrosis. | Wang S et al. | β | 2025 | β |
| Decoding the Liver-Heart Axis in Cardiometabolic Diseases. | Capone F et al. | β | 2025 | β |
| Effects of Polyphenols and Ascorbic Acid in Honey From Diverse Floral Origins on Liver Alcohol Metabolism. | Sun Z et al. | β | 2025 | β |
| Establishment and application of murine models of alcoholic liver disease: A narrative review. | Liu M et al. | β | 2025 | β |
| "General Addiction Liability" Revisited. | Watts AL et al. | β | 2025 | β |
| Identification of glycolysis-related genes and analysis of potential prognostic clinical application in oral squamous cell carcinoma. | Chen R et al. | β | 2025 | β |
| Identification of risk variants and cross-disorder pleiotropy through multi-ancestry genome-wide analysis of alcohol use disorder. | Icick R et al. | β | 2025 | β |
| Intracellular Photocatalytic NADH/NAD(P)H Oxidation for Cancer Drug Development. | Yadav AK et al. | β | 2025 | β |
| Maternal alcohol consumption during pregnancy and child development: Role of ADH1B and ALDH2 gene polymorphisms-The Yamanashi Adjunct Study of the Japan Environment and Children's Study. | Miyake K et al. | β | 2025 | β |
| Population genomics advances in frontier ethnic minorities in China. | Chen H et al. | β | 2025 | β |
| Recent advances in alcohol metabolism: from the gut to the brain. | Goldman MR et al. | β | 2025 | β |
| Regional and temporal dynamics of DNA methylation and epigenetic gene regulation in response to binge-like alcohol exposure in the adolescent mouse brain. | Cherif A et al. | β | 2025 | β |
| Relationship between age-related hearing loss and alcohol consumption in a Japanese population. | Takahashi H et al. | β | 2025 | β |
| Relationship Between Postoperative Acute Kidney Injury and Early Extubation After Pediatric Liver Transplant. | Sahinturk H et al. | β | 2025 | β |
| Role of Metabolism onΒ Alcohol Preference, Addiction, and Treatment. | Quintanilla ME et al. | β | 2025 | β |
| Selected Genetic Characteristics of the Vietnamese Minority Living in the Czech Republic. | Pham KH et al. | β | 2025 | β |
| Serum Ξ²-klotho is a potential biomarker for diagnosing alcoholic liver disease and differentiating from nonalcoholic fatty liver disease. | Fang C et al. | β | 2025 | β |
| Soybean genomeβwide association study of seed weight, protein, and oil content in the southeastern USA. | Patel J et al. | β | 2025 | β |
| The Pathophysiology of Alcohol-Associated Liver Disease: Focusing on Superoxide Dismutase 1 as a Therapeutic Target. | Gopal T et al. | β | 2025 | β |
| Unraveling time-dependent genetic components underlying alcohol response. | Hikino K et al. | β | 2025 | β |
| Acetaldehyde-mediated increase in glutamatergic and N-acetylaspartate neurometabolite levels in the midcingulate cortex of ALDH2*1/*2 heterozygous young adults. | Ueno F et al. | β | 2024 | β |
| Alcohol consumption and allergic diseases: Mendelian randomization evidence from China. | Zhu C et al. | β | 2024 | β |
| Alcohol Consumption and Cerebral Small- and Large-Vessel Diseases: A Mendelian Randomization Analysis. | Wakabayashi I | β | 2024 | β |
| Alcohol consumption and heart failure: a dose-response meta-analysis. | Wong B et al. | β | 2024 | β |
| Alcohol consumption and risk of psoriasis: Results from observational and genetic analyses in more than 100,000 individuals from the Danish general population. | Jordan A et al. | β | 2024 | β |
| Alcohol Use Disorder Polygenic Score Compared With Family History and ADH1B. | Lai D et al. | β | 2024 | β |
| ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism. | Luo J et al. | β | 2024 | β |
| A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals. | Jennings MV et al. | β | 2024 | β |
| Bitter taste function-related genes are implicated in the behavioral association between taste preference and ethanol preference in male mice. | Koh AP et al. | β | 2024 | β |
| Dual peroxisome proliferator-activated receptor Ξ±/Ξ΄ agonists: Hope for the treatment of alcohol-associated liver disease? | Zhang XY et al. | β | 2024 | β |
| Exploring patterns of alcohol use and alcohol use disorder among Asian Americans with a finer lens. | Zhang H et al. | β | 2024 | β |
| Genetic and environmental influence on alcohol intent and alcohol sips among U.S. children-Effects across sex, race, and ethnicity. | Puga T et al. | β | 2024 | β |
| Genome-Wide Analysis to Assess if Heavy Alcohol Consumption Modifies the Association between SNPs and Pancreatic Cancer Risk. | Ni Z et al. | β | 2024 | β |
| Genome-wide meta-analyses of cross substance use disorders in European, African, and Latino ancestry populations | Lai D et al. | β | 2024 | β |
| Global Gene Expression Profiling and Bioinformatics Analysis Reveal Downregulated Biomarkers as Potential Indicators for Hepatocellular Carcinoma. | Mestareehi A | β | 2024 | β |
| How to survive enormous amounts of alcohol. | Spanagel R | β | 2024 | β |
| Human adaptations to diet: Biological and cultural coevolution. | Jelenkovic A et al. | β | 2024 | β |
| Introduction: Approved treatments for alcohol use disorder by regulatory agencies. | Camarini R et al. | β | 2024 | β |
| Oxytocin as a treatment for alcohol use disorder and heavy drinking: A narrative review. | Rastogi K et al. | β | 2024 | β |
| Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model. | Li X et al. | β | 2024 | β |
| Relationship between moderate alcohol consumption, genetic polymorphisms and body weight in a population sample of Puerto Madryn, Argentina | PΓ©rez LO et al. | β | 2024 | β |
| Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental Pathways Associated with Risk of FASD Outcomes. | McKay L et al. | β | 2024 | β |
| The biochemistry of the carcinogenic alcohol metabolite acetaldehyde. | Thomas LA et al. | β | 2024 | β |
| The genetical genomic path to understanding why rats and humans consume too much alcohol. | Tabakoff B et al. | β | 2024 | β |
| The Impact of Tobacco Smoking and Alcohol Consumption on the Development of Gastric Cancers. | Hatta W et al. | β | 2024 | β |
| The web-based self-reported survey of Alcohol Use Disorders Identification Test and associated factors in Japan. | Toyama T et al. | β | 2024 | β |
| 5. Collaborative Study on the Genetics of Alcoholism: Functional genomics. | Gameiro-Ros I et al. | β | 2023 | β |
| Aged Garlic Extract Prevents Alcohol-Induced Cytotoxicity through Induction of Aldehyde Dehydrogenase 2 inΒ theΒ LiverΒ ofΒ Mice. | Kitakaze T et al. | β | 2023 | β |
| Alcohol and breast cancer. | Starek-Εwiechowicz B et al. | β | 2023 | β |
| Alcohol use disorder in community management of chronic liver diseases. | Leggio L et al. | β | 2023 | β |
| Aldehyde-Associated MutagenesisβCurrent State of Knowledge. | Vijayraghavan S et al. | β | 2023 | β |
| [Aldehyde dehydrogenase 2 rs671 genetic polymorphisms are associated with chemotherapy-induced nausea and vomiting]. | Yang Q et al. | β | 2023 | β |
| ALDH2 inhibition by lead and ethanol elicits redox imbalance and mitochondrial dysfunction in SH-SY5Y human neuroblastoma cell line: Reversion by Alda-1. | Deza-Ponzio R et al. | β | 2023 | β |
| Association between genetic risk of alcohol consumption and alcohol-related morbidity and mortality under different alcohol policy conditions: Evidence from the Finnish alcohol price reduction of 2004. | Lahtinen H et al. | β | 2023 | β |
| Association of ADH1B rs1229984, ADH1C rs698, and ALDH2 rs671 with Alcohol abuse and Alcoholic Cirrhosis in People Living in Northeast Vietnam. | Hoang YTT et al. | β | 2023 | β |
| Emerging bone marrow failure syndromes- new pieces to an unsolved puzzle. | Feurstein S | β | 2023 | β |
| Environmental neurology: Concepts and short history of an interdisciplinary approach to etiology, treatment and prevention. | Reis J et al. | β | 2023 | β |
| Estimating Prevalence of Bereavement, Its Contribution to Risk for Binge Drinking, and Other High-Risk Health States in a State Population Survey, 2019 Georgia Behavioral Risk Factor Surveillance Survey. | Miles TP et al. | β | 2023 | β |
| Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis. | Kawai Y et al. | β | 2023 | β |
| Genetic associations between alcohol phenotypes and life satisfaction: a genomic structural equation modelling approach. | Bountress KE et al. | β | 2023 | β |
| Genetic Underpinnings of the Transition From Alcohol Consumption to Alcohol Use Disorder: Shared and Unique Genetic Architectures in a Cross-Ancestry Sample. | Kember RL et al. | β | 2023 | β |
| <i>ADH1B</i>, <i>ADH1B/C</i> and <i>CYP2E1</i> Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder. | Kukowka A et al. | β | 2023 | β |
| Implementing Core Genes and an Omnigenic Model for Behaviour Traits Prediction in Genomics. | Rancelis T et al. | β | 2023 | β |
| Influence of sex in alcohol-related liver disease: Pre-clinical and clinical settings. | Bizzaro D et al. | β | 2023 | β |
| Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches. | Devi A et al. | β | 2023 | β |
| Loss of alcohol dehydrogenase 1B in cancer-associated fibroblasts: contribution to the increase of tumor-promoting IL-6 in colon cancer. | VillΓ©ger R et al. | β | 2023 | β |
| Multi-omics cannot replace sample size in genome-wide association studies. | Baranger DAA et al. | β | 2023 | β |
| Pancreatic ductal adenocarcinoma with a high expression of alcohol dehydrogenase 1B is associated with less aggressive features and a favorable prognosis. | Chida K et al. | β | 2023 | β |
| Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease. | Yan C et al. | β | 2023 | β |
| Recent Advances in Understanding of Pathogenesis of Alcohol-Associated Liver Disease. | Wu X et al. | β | 2023 | β |
| Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis. | Zhang B et al. | β | 2023 | β |
| Stomach encyclopedia: Combined single-cell and spatial transcriptomics reveal cell diversity and homeostatic regulation of human stomach. | Tsubosaka A et al. | β | 2023 | β |
| The Changing Epidemiology of Alcohol-Associated Liver Disease: Gender, Race, and Risk Factors. | Anouti A et al. | β | 2023 | β |
| The collaborative study on the genetics of alcoholism: Genetics. | Johnson EC et al. | β | 2023 | β |
| The diagnostic and prognostic value of pseudogene SIGLEC17P in lung adenocarcinoma and a preliminary functional study. | Shen X et al. | β | 2023 | β |
| The Genetically Informed Neurobiology of Addiction (GINA) model. | Bogdan R et al. | β | 2023 | β |
| The Self-Rated Effects of Alcohol Are Related to Presystemic Metabolism of Alcohol. | Bramness JG et al. | β | 2023 | β |
| A Genome-Wide Association Study Reveals a <i>BDNF</i>-Centered Molecular Network Associated with Alcohol Dependence and Related Clinical Measures. | Levchenko A et al. | β | 2022 | β |
| Alcohol Consumption and Mild Cognitive Impairment: A Mendelian Randomization Study from Rural China. | Cui Y et al. | β | 2022 | β |
| Association of Alcohol Use Disorder Risk With <i>ADH1B, DRD2, FAAH, SLC39A8, GCKR</i>, and <i>PDYN</i> Genetic Polymorphisms. | Legaki E et al. | β | 2022 | β |
| Behavioral consequences of the downstream products of ethanol metabolism involved in alcohol use disorder. | Holbrook OT et al. | β | 2022 | β |
| Brain ethanol metabolism and mitochondria. | Waddell J et al. | β | 2022 | β |
| Computational Investigation of Structural Basis for Enhanced Binding of Isoflavone Analogues with Mitochondrial Aldehyde Dehydrogenase. | Zhang Y et al. | β | 2022 | β |
| Context-dependant enhancers as a reservoir of functional polymorphisms and epigenetic markers linked to alcohol use disorders and comorbidities. | MacKenzie A et al. | β | 2022 | β |
| Crosstalk between Oxidative Stress and Inflammatory Liver Injury in the Pathogenesis of Alcoholic Liver Disease. | Yang YM et al. | β | 2022 | β |
| Diagnosis by Volatile Organic Compounds in Exhaled Breath in Exhaled Breath from Patients with Gastric and Colorectal Cancers. | Chung J et al. | β | 2022 | β |
| Estimating the time of last drinking from blood ethyl glucuronide and ethyl sulphate concentrations. | Wang L et al. | β | 2022 | β |
| Genetic Association Study Advances Idiopathic Pulmonary Fibrosis Pathophysiology and Health Equity. | Hobbs BD | β | 2022 | β |
| Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci. | WistrΓΆm ED et al. | β | 2022 | β |
| Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder. | Deak JD et al. | β | 2022 | β |
| Genome-wide meta-analysis of alcohol use disorder in East Asians. | Zhou H et al. | β | 2022 | β |
| Hazardous drinking and alcohol use disorders. | MacKillop J et al. | β | 2022 | β |
| Identification of functional genes associated with the biotransformation of limonene to trans-dihydrocarvone in Klebsiella sp. O852. | Zhang LL et al. | β | 2022 | β |
| <i>Levilactobacillus brevis</i> MG5311 Alleviates Ethanol-Induced Liver Injury by Suppressing Hepatic Oxidative Stress in C57BL/6 Mice. | Jung H et al. | β | 2022 | β |
| Investigation of Association of Rare, Functional Genetic Variants With Heavy Drinking and Problem Drinking in Exome Sequenced UK Biobank Participants. | Curtis D | β | 2022 | β |
| Molecular Alterations Caused by Alcohol Consumption in the UK Biobank: A Mendelian Randomisation Study. | O'Farrell F et al. | β | 2022 | β |
| Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development. | Fukami T et al. | β | 2022 | β |
| Positive selection acts on regulatory genetic variants in populations of European ancestry that affect ALDH2 gene expression. | Schaschl H et al. | β | 2022 | β |
| Single Nucleotide Polymorphisms of ADH1B, ADH1C and ALDH2 Genes in 235 People Living in Thai Nguyen Province of Vietnam. | Hoang YTT et al. | β | 2022 | β |
| Six Types of Tea Reduce Acute Alcoholism in Mice by Enhancing Ethanol Metabolism, Suppressing Oxidative Stress and Inflammation. | Lai X et al. | β | 2022 | β |
| The addiction risk factor: A unitary genetic vulnerability characterizes substance use disorders and their associations with common correlates. | Hatoum AS et al. | β | 2022 | β |
| Transcriptome Analysis of Protection by Dendrobium Nobile Alkaloids (DNLA) against Chronic Alcoholic Liver Injury in Mice. | Huang X et al. | β | 2022 | β |
| Virtual Screening of FDA-Approved Drugs for Enhanced Binding with Mitochondrial Aldehyde Dehydrogenase. | Zhou B et al. | β | 2022 | β |
| Acetaldehyde Enhances Alcohol Sensitivity and Protects against Alcoholism: Evidence from Alcohol Metabolism in Subjects with Variant <i>ALDH2*2</i> Gene Allele. | Chen YC et al. | β | 2021 | β |
| Adverse Reactions to Illicit Drugs (Marijuana, Opioids, Cocaine) and Alcohol. | Decuyper II et al. | β | 2021 | β |
| Alcohol and the brain: from genes to circuits. | Egervari G et al. | β | 2021 | β |
| ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis. | Hu YF et al. | β | 2021 | β |
| Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders. | Rao X et al. | β | 2021 | β |
| A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism. | Sheraj I et al. | β | 2021 | β |
| Applying genome-wide CRISPR to identify known and novel genes and pathways that modulate formaldehyde toxicity. | Zhao Y et al. | β | 2021 | β |
| Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume. | Thompson A et al. | β | 2021 | β |
| Biochemical Mechanisms Associating Alcohol Use Disorders with Cancers. | Rodriguez FD et al. | β | 2021 | β |
| Dimensional Phenotypes in Psychiatric Genetics: Lessons from Genome-Wide Association Studies of Alcohol Use Phenotypes. | Mallard TT et al. | β | 2021 | β |
| Effect of alcohol on the central nervous system to develop neurological disorder: pathophysiological and lifestyle modulation can be potential therapeutic options for alcohol-induced neurotoxication. | Pervin Z et al. | β | 2021 | β |
| Ethnic Differences in Serum Levels of microRNAs Potentially Regulating Alcohol Dehydrogenase 1B and Aldehyde Dehydrogenase 2. | Wakabayashi I et al. | β | 2021 | β |
| Exploring the Role of Alcohol Metabolizing Genotypes in a 12-Week Clinical Trial of Naltrexone for Alcohol Use Disorder. | Castaldelli-Maia JM et al. | β | 2021 | β |
| Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population. | Clarke TK et al. | β | 2021 | β |
| Genetics of substance use disorders: a review. | Deak JD et al. | β | 2021 | β |
| Genetics of substance use disorders in the era of big data. | Gelernter J et al. | β | 2021 | β |
| Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations. | Lai D et al. | β | 2021 | β |
| Long tracks of homozygosity predict the severity of alcohol use disorders in an American Indian population. | Peng Q et al. | β | 2021 | β |
| Maternal and offspring genetic risk score analyses of fetal alcohol exposure and attention-deficit hyperactivity disorder risk in offspring. | Haan E et al. | β | 2021 | β |
| Metal-Based Catalytic Drug Development for Next-Generation Cancer Therapy. | Fan Z et al. | β | 2021 | β |
| Oral enzymatic detoxification system: Insights obtained from proteome analysis to understand its potential impact on aroma metabolization. | Schwartz M et al. | β | 2021 | β |
| Oxidative Stress-A Key Player in the Course of Alcohol-Related Liver Disease. | Michalak A et al. | β | 2021 | β |
| Perspective on Beyond Statistical Significance: Finding Meaningful Effects. | Edenberg HJ | β | 2021 | β |
| Punch-Drunk or Drunken Boxing? The Etiology of Alcohol-Related Physical Violence through Adolescence and Young Adulthood. | Deutsch AR | β | 2021 | β |
| Regulation of Alcohol and Acetaldehyde Metabolism by a Mixture of <i>Lactobacillus</i> and <i>Bifidobacterium</i> Species in Human. | Jung SJ et al. | β | 2021 | β |
| Relationship between rice farming and polygenic scores potentially linked to agriculture in China. | Zhu C et al. | β | 2021 | β |
| Sex Differences in Alcohol Consumption and Alcohol-Associated Liver Disease. | Kezer CA et al. | β | 2021 | β |
| Targeting Epigenetic Mechanisms to Treat Alcohol Use Disorders (AUD). | Rodriguez FD | β | 2021 | β |
| The Gut Microbiome and Substance Use Disorder. | Russell JT et al. | β | 2021 | β |
| The Role of Alcohol Dehydrogenase in Drug Metabolism: Beyond Ethanol Oxidation. | Di L et al. | β | 2021 | β |
| Transfer hydrogenation catalysis in cells. | Banerjee S et al. | β | 2021 | β |
| A Call to Action: A Systematic Review Examining the Failure to Include Females and Members of Minoritized Racial/Ethnic Groups in Clinical Trials of Pharmacological Treatments for Alcohol Use Disorder. | Schick MR et al. | β | 2020 | β |
| Alcohol Consumption and Progression of Chronic Kidney Disease: Results From the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease. | Joo YS et al. | β | 2020 | β |
| Alcohol consumption in later life and reaching longevity: the Netherlands Cohort Study. | van den Brandt PA et al. | β | 2020 | β |
| Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans. | Parker CC et al. | β | 2020 | β |
| Alcohol Use and Depression: A Mendelian Randomization Study From China. | Zhu C et al. | β | 2020 | β |
| An update on the role of common genetic variation underlying substance use disorders. | Johnson EC et al. | β | 2020 | β |
| Association between rs1229984 in ADH1B and cancer prevalence in a Japanese population. | Govind P et al. | β | 2020 | β |
| Bottom-Up Construction of a Minimal System for Cellular Respiration and Energy Regeneration. | Biner O et al. | β | 2020 | β |
| E487K-Induced Disorder in Functionally Relevant Dynamics of Mitochondrial Aldehyde Dehydrogenase 2. | Matsumoto S et al. | β | 2020 | β |
| Fetal alcohol spectrum disorders: Genetic and epigenetic mechanisms. | Kaminen-Ahola N | β | 2020 | β |
| Flying Together: <i>Drosophila</i> as a Tool to Understand the Genetics of Human Alcoholism. | Lathen DR et al. | β | 2020 | β |
| Hepatic injury and inflammation alter ethanol metabolism and drinking behavior. | Ren T et al. | β | 2020 | β |
| Identification of Functional Genetic Variants Associated With Alcohol Dependence and Related Phenotypes Using a High-Throughput Assay. | Thapa KS et al. | β | 2020 | β |
| <i>Ent</i>-Peniciherqueinone Suppresses Acetaldehyde-Induced Cytotoxicity and Oxidative Stress by Inducing ALDH and Suppressing MAPK Signaling. | Oh T et al. | β | 2020 | β |
| Immobilization of alcohol dehydrogenase from Saccharomyces cerevisiae onto carboxymethyl dextran-coated magnetic nanoparticles: a novel route for biocatalyst improvement via epoxy activation. | VasiΔ K et al. | β | 2020 | β |
| Influence of Comorbid Psychiatric Disorders on the Risk of Development of Alcohol Dependence by Genetic Variations of ALDH2 and ADH1B. | Itoh M et al. | β | 2020 | β |
| Prognostic implications of alcohol dehydrogenases in hepatocellular carcinoma. | Liu X et al. | β | 2020 | β |
| Protection of retinal function and morphology in MNU-induced retinitis pigmentosa rats by ALDH2: an in-vivo study. | Yan W et al. | β | 2020 | β |
| Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse. | Sanchez-Roige S et al. | β | 2020 | β |
| Reply to Brewer: Liver-targeted ALDH2 inhibition may reduce alcohol-seeking behaviors with limited side effects. | Guillot A et al. | β | 2020 | β |
| Ethanol activates immune response in lymphoblastoid cells. | McClintick JN et al. | β | 2019 | β |
| Ethyl glucuronide hair testing: A review. | Biondi A et al. | β | 2019 | β |
| Genetic evidence for assortative mating on alcohol consumption in the UK Biobank. | Howe LJ et al. | β | 2019 | β |
| Genetics of Alcoholism. | Edenberg HJ et al. | β | 2019 | β |
| Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations. | Peterson RE et al. | β | 2019 | β |
| Genome-wide association study of alcohol dependence in male Han Chinese and cross-ethnic polygenic risk score comparison. | Sun Y et al. | β | 2019 | β |
| How Much Do You Drink on Your Heavy DrinkingΒ Day? | Edenberg HJ | β | 2019 | β |
| Psychosocial moderation of polygenic risk for cannabis involvement: the role of trauma exposure and frequency of religious service attendance. | Meyers JL et al. | β | 2019 | β |
| Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking. | Guillot A et al. | β | 2019 | β |
| The Genetic Relationship Between Alcohol Consumption and Aspects of Problem Drinking in an Ascertained Sample. | Johnson EC et al. | β | 2019 | β |