Twin studies on obsessive-compulsive disorder: a review.
paper
Cited
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- Authors
- van Grootheest, DaniΓ«l S; Cath, DaniΓ«lle C; Beekman, Aartjan T; Boomsma, Dorret I
- Year
- 2005
- Journal
- Twin research and human genetics : the official journal of the International Society for Twin Studies
- PMID
- 16212834
- DOI
- 10.1375/183242705774310060
Genetic factors have historically been thought of as important in the development of obsessive-compulsive disorder (OCD). For the estimation of the relative importance of genetic and environmental factors, twin studies are an obvious approach. Twin studies of OCD have a long history, starting in 1929. In this review, over 70 years of twin research of OCD is presented, using four different approaches that represent the steps in the twin research of OCD from past to present. These steps include (1) case-studies of twins with OCD from the old literature; (2) twin studies of OCD using Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria; (3) twin studies of OCD using a dimensional approach, comparing resemblances in monozygotic and dizygotic twins; and (4) twin studies of OCD using a dimensional approach, analyzing the data with Structural Equation Modeling. It is concluded that only the studies using the last method have convincingly shown that, in children, obsessive-compulsive (OC) symptoms are heritable, with genetic influences in the range of 45% to 65%. In adults, studies are suggestive for a genetic influence on OC symptoms, ranging from 27% to 47%, but a large twin study using a biometrical approach with continuous data is still needed to provide conclusive evidence. Strategies for future twin studies of OCD are discussed.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Case Series on Obsessive-compulsive Disorder in Twins: Phenotypic Divergence and Shared Therapeutic Challenges. | Chouhan A et al. | β | 2026 | β |
| Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders. | Giacomel A et al. | β | 2026 | β |
| Astrocyte Dysfunctions in Obsessive Compulsive Disorder: Rethinking Neurobiology and Therapeutic Targets. | Gonzalez L et al. | β | 2025 | β |
| Characterizing Rare DNA Copy-Number Variants in Pediatric Obsessive-Compulsive Disorder. | Abdallah SB et al. | β | 2025 | β |
| De novo variant analysis of childhood-onset obsessive-compulsive disorder in the French-Canadian population. | Bornais K et al. | β | 2025 | β |
| Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. | Strom NI et al. | β | 2025 | β |
| Obsessive Beliefs, Metacognitive Beliefs, and Rumination in Parents of Adolescents with and Without Obsessive-Compulsive Disorder: A Linear Mixed-Effects Model. | MΔ±sΔ±r E et al. | β | 2025 | β |
| Pharmacogenetics of obsessive-compulsive disorder: Investigations of intragenic and regulatory region genetic variations. | Zai G et al. | β | 2025 | β |
| Associations between somatomotor-putamen resting state connectivity and obsessive-compulsive symptoms vary as a function of stress during early adolescence: Data from the ABCD study. | Petrie DJ et al. | β | 2024 | β |
| Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population. | Strom NI et al. | β | 2024 | β |
| Genomics of severe and treatment-resistant obsessive-compulsive disorder treated with deep brain stimulation: A preliminary investigation. | Chen LL et al. | β | 2024 | β |
| Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol. | Crowley JJ et al. | β | 2024 | β |
| Neurobiology of Obsessive-Compulsive Disorder from Genes to Circuits: Insights from Animal Models. | Zhang YD et al. | β | 2024 | β |
| Unraveling the Boundaries, Overlaps, and Connections between Schizophrenia and Obsessive-Compulsive Disorder (OCD). | Pardossi S et al. | β | 2024 | β |
| Autoantibodies in patients with obsessive-compulsive disorder: a systematic review. | Denzel D et al. | β | 2023 | β |
| Genetic influences on the interplay between obsessive-compulsive behavior symptoms and cannabis use during adolescence. | Kutzner J et al. | β | 2023 | β |
| Genomics of Obsessive-Compulsive Disorder and Related Disorders: What the Clinician Needs to Know. | Crowley JJ | β | 2023 | β |
| Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating. | Ho EV et al. | β | 2023 | β |
| Obsessive-Compulsive Disorder and Its Cross-Generational Familial Association With Anxiety Disorders in a National Swedish Extended Adoption Study. | Kendler KS et al. | β | 2023 | β |
| Relationship between insight level and clinical and familial features in pediatric obsessive-compulsive disorder. | Miniksar DY et al. | β | 2023 | β |
| The genetic epidemiology of obsessive-compulsive disorder: a systematic review and meta-analysis. | Blanco-Vieira T et al. | β | 2023 | β |
| The Motivational Determinants of Human Action, Their Neural Bases and Functional Impact in Adolescents With Obsessive-Compulsive Disorder. | Perkes IE et al. | β | 2023 | β |
| A prospective clinical cohort-based study of the prevalence of OCD, obsessive compulsive and related disorders, and tics in families of patients with OCD. | Carmi L et al. | β | 2022 | β |
| Lived experiences of children and adolescents with obsessive-compulsive disorder: interpretative phenomenological analysis. | Sravanti L et al. | β | 2022 | β |
| Tourettic OCD: Current understanding and treatment challenges of a unique endophenotype. | Katz TC et al. | β | 2022 | β |
| A dimensional perspective on the genetics of obsessive-compulsive disorder. | Strom NI et al. | β | 2021 | β |
| An association of Myelin Oligodendrocyte Glycoprotein (MOG) gene variants with white matter volume in pediatric obsessive-compulsive disorder. | Zai G et al. | β | 2021 | β |
| Are There Familial Patterns of Symptom Dimensions in Obsessive-Compulsive Disorder? | Balachander S et al. | β | 2021 | β |
| Association Between Obsessive-Compulsive Symptom Dimensions in Mothers and Psychopathology in Their Children. | Blanco-Vieira T et al. | β | 2021 | β |
| Bidirectional Behavioral Selection in Mice: A Novel Pre-clinical Approach to Examining Compulsivity. | Mitra S et al. | β | 2021 | β |
| Clinical validation of the parent-report Toronto Obsessive-Compulsive Scale (TOCS): A pediatric open-source rating scale. | Lambe LJ et al. | β | 2021 | β |
| Developmental Considerations in Obsessive Compulsive Disorder: Comparing Pediatric and Adult-Onset Cases. | Geller DA et al. | β | 2021 | β |
| Genetics of obsessive-compulsive disorder. | Mahjani B et al. | β | 2021 | β |
| Genetics of OCD and Related Disorders; Searching for Shared Factors. | GrΓΌnblatt E | β | 2021 | β |
| Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder. | Burton CL et al. | β | 2021 | β |
| Neurocognitive Endophenotypes of OCD. | Vaghi MM | β | 2021 | β |
| Specialty knowledge and competency standards for pharmacotherapy for adult obsessive-compulsive disorder. | Pittenger C et al. | β | 2021 | β |
| The Brain-Derived Neurotrophic Factor Val66Met Polymorphism Is Associated With Female Obsessive-Compulsive Disorder: An Updated Meta-Analysis of 2765 Obsessive-Compulsive Disorder Cases and 5558 Controls. | Shang Y et al. | β | 2021 | β |
| Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder. | Piantadosi SC et al. | β | 2021 | β |
| De Novo Damaging DNA Coding Mutations Are Associated With Obsessive-Compulsive Disorder and Overlap With Tourette's Disorder and Autism. | Cappi C et al. | β | 2020 | β |
| Genetic meta-analysis of obsessive-compulsive disorder and self-report compulsive symptoms. | Smit DJA et al. | β | 2020 | β |
| Heritability of overlapping impulsivity and compulsivity dimensional phenotypes. | Tiego J et al. | β | 2020 | β |
| Nordic OCD & Related Disorders Consortium: Rationale, design, and methods. | Mataix-Cols D et al. | β | 2020 | β |
| Obsessive-compulsive disorder and attention-deficit/hyperactivity disorder: distinct associations with DNA methylation and genetic variation. | Goodman SJ et al. | β | 2020 | β |
| Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling. | Bralten J et al. | β | 2020 | β |
| Are punitive parenting and stressful life events environmental risk factors for obsessive-compulsive symptoms in youth? A longitudinal twin study. | Krebs GC et al. | β | 2019 | β |
| Challenges in the diagnosis and treatment of pediatric obsessive-compulsive disorder. | Westwell-Roper C et al. | β | 2019 | β |
| Genetics of obsessive-compulsive disorder. | Purty A et al. | β | 2019 | β |
| Sex differences in the genetic architecture of obsessive-compulsive disorder. | Khramtsova EA et al. | β | 2019 | β |
| Assessing the evidence for shared genetic risks across psychiatric disorders and traits. | Martin J et al. | β | 2018 | β |
| Association of serotonin receptor 2a haplotypes with obsessive-compulsive disorder and its treatment response in Iranian patients: a genetic and pharmacogenetic study. | Sina M et al. | β | 2018 | β |
| Heritability of obsessive-compulsive trait dimensions in youth from the general population. | Burton CL et al. | β | 2018 | β |
| Impaired cognitive plasticity and goal-directed control in adolescent obsessive-compulsive disorder. | Gottwald J et al. | β | 2018 | β |
| Neuroscientifically Informed Formulation and Treatment Planning for Patients With Obsessive-Compulsive Disorder: A Review. | Dougherty DD et al. | β | 2018 | β |
| Obsessive-compulsive symptoms in children with first degree relatives diagnosed with obsessive-compulsive disorder. | Chacon P et al. | β | 2018 | β |
| Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis. | International Obsessive Compulsive Disorder Foundation Genetics Collaborative (IOCDF-GC) and OCD Collaborative Genetics Association Studies (OCGAS) | β | 2018 | β |
| Significant concordance of genetic variation that increases both the risk for obsessive-compulsive disorder and the volumes of the nucleus accumbens and putamen. | Hibar DP et al. | β | 2018 | β |
| Glutamate Genetics in Obsessive-Compulsive Disorder: A Review. | Rajendram R et al. | β | 2017 | β |
| Heritability of tic disorders: a twin-family study. | ZilhΓ£o NR et al. | β | 2017 | β |
| High resolution chromosomal microarray analysis in paediatric obsessive-compulsive disorder. | GrΓΌnblatt E et al. | β | 2017 | β |
| Rodent models of obsessive compulsive disorder: Evaluating validity to interpret emerging neurobiology. | Zike I et al. | β | 2017 | β |
| Toxoplasma-infected subjects report an Obsessive-Compulsive Disorder diagnosis more often and score higher in Obsessive-Compulsive Inventory. | Flegr J et al. | β | 2017 | β |
| Cross-Disorder Genetic Analysis of Tic Disorders, Obsessive-Compulsive, and Hoarding Symptoms. | ZilhΓ£o NR et al. | β | 2016 | β |
| Learning From Animal Models of Obsessive-Compulsive Disorder. | Monteiro P et al. | β | 2016 | β |
| Obsessive-Compulsive Disorder: The Process of Parental Adaptation and Implications for Genetic Counseling. | Andrighetti H et al. | β | 2016 | β |
| Polymorphisms within the neuronal cadherin (CDH2) gene are associated with obsessive-compulsive disorder (OCD) in a South African cohort. | McGregor NW et al. | β | 2016 | β |
| Traumatic and Adverse Attachment Childhood Experiences are not Characteristic of OCD but of Depression in Adolescents. | Ivarsson T et al. | β | 2016 | β |
| Validity of Quinpirole Sensitization Rat Model of OCD: Linking Evidence from Animal and Clinical Studies. | Stuchlik A et al. | β | 2016 | β |
| An association study between DLGAP1 rs11081062 and EFNA5 rs26728 polymorphisms with obsessive-compulsive disorder in a Chinese Han population. | Li J et al. | β | 2015 | β |
| COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based association study. | Sampaio AS et al. | β | 2015 | β |
| Genetic and environmental influences on obsessive-compulsive behaviour across development: a longitudinal twin study. | Krebs G et al. | β | 2015 | β |
| Microribonucleic acid dysregulations in children and adolescents with obsessive-compulsive disorder. | Kandemir H et al. | β | 2015 | β |
| Obsessive-compulsive disorder in children and adolescents. | Krebs G et al. | β | 2015 | β |
| Pediatric obsessive-compulsive disorder: an update for advanced practice psychiatric nurses. | Kameg KM et al. | β | 2015 | β |
| Riluzole augmentation in treatment-refractory obsessive-compulsive disorder: a pilot randomized placebo-controlled trial. | Pittenger C et al. | β | 2015 | β |
| Subcortical and cortical morphological anomalies as an endophenotype in obsessive-compulsive disorder. | Shaw P et al. | β | 2015 | β |
| Candidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder. | Tang R et al. | β | 2014 | β |
| Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. | McGrath LM et al. | β | 2014 | β |
| Genetics of obsessive-compulsive disorder and related disorders. | Browne HA et al. | β | 2014 | β |
| Neuropsychological and Clinical Profiles of Children and Adolescents Diagnosed with Childhood Obsessive Compulsive Disorder. | Baykal S et al. | β | 2014 | β |
| Obsessive compulsive symptom dimensions and neuroticism: An examination of shared genetic and environmental risk. | Bergin J et al. | β | 2014 | β |
| Partitioning the etiology of hoarding and obsessive-compulsive symptoms. | Mathews CA et al. | β | 2014 | β |
| Prevalence and heritability of obsessive-compulsive spectrum and anxiety disorder symptoms: A survey of the Australian Twin Registry. | LΓ³pez-SolΓ C et al. | β | 2014 | β |
| Psychiatrists' views of the genetic bases of mental disorders and behavioral traits and their use of genetic tests. | Klitzman R et al. | β | 2014 | β |
| The neurobiological link between OCD and ADHD. | Brem S et al. | β | 2014 | β |
| Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder. | Walitza S et al. | β | 2014 | β |
| Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity. | Murphy DL et al. | β | 2013 | β |
| Association between SLC1A1 gene and early-onset OCD in the Han Chinese population: a case-control study. | Wu H et al. | β | 2013 | β |
| Genome-wide association study of obsessive-compulsive disorder. | Stewart SE et al. | β | 2013 | β |
| Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study. | Wu K et al. | β | 2013 | β |
| In a double-blind, randomized and placebo-controlled trial, adjuvant memantine improved symptoms in inpatients suffering from refractory obsessive-compulsive disorders (OCD). | Haghighi M et al. | β | 2013 | β |
| Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive-compulsive symptoms. | Cai J et al. | β | 2013 | β |
| Interaction of SLC1A1 gene variants and life stress on pharmacological resistance in obsessive-compulsive disorder. | Real E et al. | β | 2013 | β |
| Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1. | Stewart SE et al. | β | 2013 | β |
| Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. | Davis LK et al. | β | 2013 | β |
| The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) influences age at onset of obsessive-compulsive disorder. | Lennertz L et al. | β | 2013 | β |
| Assessment and medication management of paediatric obsessive-compulsive disorder. | Stewart SE et al. | β | 2012 | β |
| Connectomic intermediate phenotypes for psychiatric disorders. | Fornito A et al. | β | 2012 | β |
| Do cognitive functions in obsessive-compulsive disorder change after treatment? A systematic review and a double case report. | Vandborg SK et al. | β | 2012 | β |
| Environmental effects on compulsive tail chasing in dogs. | Tiira K et al. | β | 2012 | β |
| Genome-wide linkage analysis of obsessive-compulsive disorder implicates chromosome 1p36. | Mathews CA et al. | β | 2012 | β |
| Is obsessive-compulsive disorder an anxiety disorder, and what, if any, are spectrum conditions? A family study perspective. | Bienvenu OJ et al. | β | 2012 | β |
| Pilot study on HTR2A promoter polymorphism, -1438G/A (rs6311) and a nearby copy number variation showed association with onset and severity in early onset obsessive-compulsive disorder. | Walitza S et al. | β | 2012 | β |
| The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder. | Wu K et al. | β | 2012 | β |
| Association between polymorphisms in GRIK2 gene and obsessive-compulsive disorder: a family-based study. | Sampaio AS et al. | β | 2011 | β |
| Major depressive disorder in a family study of obsessive-compulsive disorder with pediatric probands. | Hanna GL et al. | β | 2011 | β |
| Obsessive-compulsive disorder in children and adolescents. | Walitza S et al. | β | 2011 | β |
| Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. | Nemoda Z et al. | β | 2011 | β |
| Attachment states of mind in adolescents with Obsessive-Compulsive Disorder and/or depressive disorders: a controlled study. | Ivarsson T et al. | β | 2010 | β |
| Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset. | Correia S et al. | β | 2010 | β |
| Brain activation during cognitive planning in twins discordant or concordant for obsessive-compulsive symptoms. | den Braber A et al. | β | 2010 | β |
| Genetics of early-onset obsessive-compulsive disorder. | Walitza S et al. | β | 2010 | β |
| Glutamate and the Treatment of Obsessive-Compulsive Disorder. | Macmaster FP et al. | β | 2010 | β |
| NEUROBIOLOGICAL EVIDENCE SUPPORTING GLUTAMATE'S ROLE IN PEDIATRIC OBSESSIVE COMPULSIVE DISORDER. | MacMaster FP et al. | β | 2010 | β |
| The Genetics of Obsessive-Compulsive Disorder. | Bloch MH et al. | β | 2010 | β |
| The genetics of obsessive-compulsive disorder: a review. | Pauls DL | β | 2010 | β |
| The role of the COMT Val(158)Met polymorphism in the phenotypic expression of obsessive-compulsive disorder. | Katerberg H et al. | β | 2010 | β |
| Translational neuroimaging research in pediatric obsessive-compulsive disorder. | MacMaster FP | β | 2010 | β |
| Assessing the validity of current mouse genetic models of obsessive-compulsive disorder. | Wang L et al. | β | 2009 | β |
| Children with obsessive-compulsive disorder: are they just "little adults"? | Kalra SK et al. | β | 2009 | β |
| Genetics of anxiety and trauma-related disorders. | Norrholm SD et al. | β | 2009 | β |
| Glutamate system genes associated with ventral prefrontal and thalamic volume in pediatric obsessive-compulsive disorder. | Arnold PD et al. | β | 2009 | β |
| Recent advances in the genetics of obsessive-compulsive disorder. | Samuels JF | β | 2009 | β |
| Structure of genetic and environmental risk factors for dimensional representations of DSM-IV anxiety disorders. | Tambs K et al. | β | 2009 | β |
| Symptom dimensions and subtypes of obsessive-compulsive disorder: a developmental perspective. | Leckman JF et al. | β | 2009 | β |
| The role of the brain-derived neurotrophic factor (BDNF) val66met variant in the phenotypic expression of obsessive-compulsive disorder (OCD). | Katerberg H et al. | β | 2009 | β |
| Brain imaging in pediatric obsessive-compulsive disorder. | MacMaster FP et al. | β | 2008 | β |
| Genetic and environmental influences on obsessive-compulsive disorder. | Grisham JR et al. | β | 2008 | β |
| Glutamatergic Synaptic Dysfunction and Obsessive-Compulsive Disorder. | Ting JT et al. | β | 2008 | β |
| The genetics of obsessive compulsive disorder: a review of the evidence. | Pauls DL | β | 2008 | β |
| Evidence for a susceptibility locus on chromosome 10p15 in early-onset obsessive-compulsive disorder. | Hanna GL et al. | β | 2007 | β |
| Parental psychopathology in child and adolescent obsessive-compulsive disorder. | Calvo R et al. | β | 2007 | β |
| Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism. | Hasler G et al. | β | 2006 | β |
| The genetic studies of obsessive-compulsive disorder and its future directions. | Kim SJ et al. | β | 2006 | β |
| Worsening of obsessive-compulsive symptoms under methadone tapering. | Khazaal Y et al. | β | 2006 | β |