Impulsivity, frontal lobes and risk for addiction.

paper Cited Public

Authors: Crews, Fulton Timm; Boettiger, Charlotte Ann
Year: 2009
Journal: Pharmacology, biochemistry, and behavior
PMID: 19410598
DOI: 10.1016/j.pbb.2009.04.018
PMCID: PMC2730661

Alcohol and substance abuse disorders involve continued use of substances despite negative consequences, i.e. loss of behavioral control of drug use. The frontal-cortical areas of the brain oversee behavioral control through executive functions. Executive functions include abstract thinking, motivation, planning, attention to tasks and inhibition of impulsive responses. Impulsiveness generally refers to premature, unduly risky, poorly conceived actions. Dysfunctional impulsivity includes deficits in attention, lack of reflection and/or insensitivity to consequences, all of which occur in addiction [Evenden JL. Varieties of impulsivity. Psychopharmacology (Berl) 1999;146:348-361.; de Wit H. Impulsivity as a determinant and consequence of drug use: a review of underlying processes. Addict Biol 2009;14:22-31]. Binge drinking models indicate chronic alcohol damages in the corticolimbic brain regions [Crews FT, Braun CJ, Hoplight B, Switzer III RC, Knapp DJ. Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats. Alcohol Clin Exp Res 2000;24:1712-1723] causing reversal learning deficits indicative of loss of executive function [Obernier JA, White AM, Swartzwelder HS, Crews FT. Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats. Pharmacol Biochem Behav 2002b;72:521-532]. Genetics and adolescent age are risk factors for alcoholism that coincide with sensitivity to alcohol-induced neurotoxicity. Cortical degeneration from alcohol abuse may increase impulsivity contributing to the development, persistence and severity of alcohol use disorders. Interestingly, abstinence results in bursts of neurogenesis and brain regrowth [Crews FT, Nixon K. Mechanisms of neurodegeneration and regeneration in alcoholism. Alcohol Alcohol 2009;44:115-127]. Treatments for alcoholism, including naltrexone pharmacotherapy and psychotherapy may work through improving executive functions. This review will examine the relationships between impulsivity and executive function behaviors to changes in cortical structure during alcohol dependence and recovery.

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40	8. Summary	The discovery of a key role of the frontal cortex in addiction provides new approaches to therapy.…

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Adolescence as a critical window for developing an alcohol use disorder: current findings in neuroscience.	2010	20224404

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Behavioral and Cerebral Impairments Associated with Binge Drinking in Youth: A Critical Review.	Lannoy S et al.	—	2019	→
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Cannabidiol as a Novel Candidate Alcohol Use Disorder Pharmacotherapy: A Systematic Review.	Turna J et al.	—	2019	→
Chronic alcohol exposure induced gut microbiota dysbiosis and its correlations with neuropsychic behaviors and brain BDNF/Gabra1 changes in mice.	Xu Z et al.	—	2019	→
Decreased event-related theta power and phase-synchrony in young binge drinkers during target detection: An anatomically-constrained MEG approach.	Correas A et al.	—	2019	→
Differentiation between young adult Internet addicts, smokers, and healthy controls by the interaction between impulsivity and temporal lobe thickness.	Zsidó AN et al.	—	2019	→
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Dynamic Causal Modeling of Insular, Striatal, and Prefrontal Cortex Activities During a Food-Specific Go/NoGo Task.	He Q et al.	—	2019	→
Earlier Alcohol Use and Lower Neuropsychological Performance in Brazilian Adolescence: Is the School Environment Related to This?	Willhelm AR et al.	—	2019	→
Ethanol induces interferon expression in neurons via TRAIL: role of astrocyte-to-neuron signaling.	Lawrimore CJ et al.	—	2019	→
Exercise-driven restoration of the alcohol-damaged brain.	West RK et al.	—	2019	→
Explaining Excessive Weight Gain during Early Recovery from Addiction.	Gottfredson NC et al.	—	2019	→
Facets of impulsivity and alcohol use: What role do emotions play?	Herman AM et al.	—	2019	→
Functional and structural connectivity of the executive control network in college binge drinkers.	Sousa SS et al.	—	2019	→
Increased Nucleus Accumbens Volume in College Binge Drinkers - Preliminary Evidence From Manually Segmented MRI Analysis.	Sousa SS et al.	—	2019	→
Internalizing and externalizing factors on the pathway from adverse experiences in childhood to non-medical prescription opioid use in adulthood.	Quinn K et al.	—	2019	→
Internet addiction associated with right pars opercularis in females.	Inhóf O et al.	—	2019	→
Its complicated: The relationship between alcohol and microglia in the search for novel pharmacotherapeutic targets for alcohol use disorders.	Melbourne JK et al.	—	2019	→
Methamphetamine Users Show No Behavioral Deficits in Response Selection After Protracted Abstinence.	Bensmann W et al.	—	2019	→
Modulating Activity in the Prefrontal Cortex Changes Intertemporal Choice for Loss: A Transcranial Direct Current Stimulation Study.	Xiong G et al.	—	2019	→
Prelimbic Cortical Neurons Track Preferred Reward Value and Reflect Impulsive Choice during Delay Discounting Behavior.	Sackett DA et al.	—	2019	→
Pubertal hormones mediate sex differences in levels of myelin basic protein in the orbitofrontal cortex of adult rats.	Darling JS et al.	—	2019	→
Sexual behaviour is impaired by the abused inhalant toluene in adolescent male rats.	Violante-Soria V et al.	—	2019	→
Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway.	Yohn SE et al.	—	2019	→
Structural and Functional Alterations in Betel-Quid Chewers: A Systematic Review of Neuroimaging Findings.	Sariah A et al.	—	2019	→
The combination of swimming and curcumin consumption may improve spatial memory recovery after binge ethanol drinking.	Feizolahi F et al.	—	2019	→
The Correlation between the Frontostriatal Network and Impulsivity in Internet Gaming Disorder.	Kim JY et al.	—	2019	→
The Mediating Effects of Affect on Associations between Impulsivity or Resilience and Internet Gaming Disorder.	Shin D et al.	—	2019	→
The Mediating Role of Coping Styles on Impulsivity, Behavioral Inhibition/Approach System, and Internet Addiction in Adolescents From a Gender Perspective.	Li Q et al.	—	2019	→
The neurobiology of impulsivity and substance use disorders: implications for treatment.	Kozak K et al.	—	2019	→
The role of the visual association cortex in scaffolding prefrontal cortex development: A novel mechanism linking socioeconomic status and executive function.	Rosen ML et al.	—	2019	→
Young frequent binge drinkers show no behavioral deficits in inhibitory control and cognitive flexibility.	Bensmann W et al.	—	2019	→
Adolescent Brain Surface Area Pre- and Post-Cannabis and Alcohol Initiation.	Infante MA et al.	—	2018	→
Adolescent development of cortical oscillations: Power, phase, and support of cognitive maturation.	Marek S et al.	—	2018	→
Adolescent morphine exposure induces immediate and long-term increases in impulsive behavior.	Moazen P et al.	—	2018	→
ADX-47273, a mGlu5 receptor positive allosteric modulator, attenuates deficits in cognitive flexibility induced by withdrawal from 'binge-like' ethanol exposure in rats.	Marszalek-Grabska M et al.	—	2018	→
Alcohol Consumption and Subclinical Findings on Cognitive Function, Biochemical Indexes, and Cortical Anatomy in Cognitively Normal Aging Han Chinese Population.	Sun L et al.	—	2018	→
Alcohol Hangover Increases Conflict Load via Faster Processing of Subliminal Information.	Zink N et al.	—	2018	→
Alcohol Use in Adolescence and Later Working Memory: Findings From a Large Population-Based Birth Cohort.	Mahedy L et al.	—	2018	→
Association of 24 h maternal deprivation with a saline injection in the neonatal period alters adult stress response and brain monoamines in a sex-dependent fashion.	Cabbia R et al.	—	2018	→
Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits.	Renteria R et al.	—	2018	→
Claustrum circuit components for top-down input processing and cortical broadcast.	White MG et al.	—	2018	→
Cortical Expression of the Polysialylated Isoform of the Neural Cell Adhesion Molecule on Brain Tissue to Recognize Drug-Related Death: An Exploratory Analysis.	Cirielli V et al.	—	2018	→
Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics.	Bazov I et al.	—	2018	→
Early deprivation disruption of associative learning is a developmental pathway to depression and social problems.	Sheridan MA et al.	—	2018	→
Effects of a Theta/Sensorimotor Rhythm Neurofeedback Training Protocol on Measures of Impulsivity, Drug Craving, and Substance Abuse in Forensic Psychiatric Patients With Substance Abuse: Randomized Controlled Trial.	Fielenbach S et al.	—	2018	→
Effects of neuromodulation on cognitive performance in individuals exhibiting addictive behaviors: A systematic review.	Naish KR et al.	—	2018	→
Effects of neuromodulation on cognitive performance in individuals exhibiting addictive behaviour: a systematic review protocol.	Naish KR et al.	—	2018	→
Identifying Inhibitory Subcomponents Associated with Changes in Binge Drinking Behavior: A 6-Month Longitudinal Design.	Paz AL et al.	—	2018	→
Impulsivity as a mechanism linking child abuse and neglect with substance use in adolescence and adulthood.	Oshri A et al.	—	2018	→
Innate Immune Signaling and Alcohol Use Disorders.	Coleman LG et al.	—	2018	→
Light social drinkers are more distracted by irrelevant information from an induced attentional bias than heavy social drinkers.	Knight HC et al.	—	2018	→
Metabolic alterations in the anterior cingulate cortex and related cognitive deficits in late adolescent methamphetamine users.	Kim JE et al.	—	2018	→
Neuroimaging, neuromodulation, and population health: the neuroscience of chronic disease prevention.	Hall PA et al.	—	2018	→
Patterns of Harmful Alcohol Consumption among Truck Drivers: Implications for Occupational Health and Work Safety from a Systematic Review and Meta-Analysis.	Bragazzi NL et al.	—	2018	→
Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder.	Bachi K et al.	—	2018	→
Repeated toluene exposure increases the excitability of layer 5 pyramidal neurons in the prefrontal cortex of adolescent rats.	Armenta-Resendiz M et al.	—	2018	→
Schizophrenia and Criminal Responsibility: A Systematic Review.	Tsimploulis G et al.	—	2018	→
Social stress during adolescence activates long-term microglia inflammation insult in reward processing nuclei.	Rodríguez-Arias M et al.	—	2018	→
Sweet taste preference in binge-eating disorder: A preliminary investigation.	Goodman EL et al.	—	2018	→
The Role of Impulsivity and Expectancies in Predicting Marijuana Use: An Application of the Acquired Preparedness Model.	Luba R et al.	—	2018	→
The role of the orbitofrontal cortex in alcohol use, abuse, and dependence.	Moorman DE	—	2018	→
To take or not to take: the association between perceived addiction risk, expected analgesic response and likelihood of trying novel pain relievers in self-identified chronic pain patients.	Tompkins DA et al.	—	2018	→
Trait Impulsivity in Alcohol-naïve Offspring at High Risk for Alcoholism.	Kumar R et al.	—	2018	→
Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle.	Gonzalez-Cuevas G et al.	—	2018	→
Acute alcohol effects on set-shifting and its moderation by baseline individual differences: a latent variable analysis.	Korucuoglu O et al.	—	2017	→
Adolescent intermittent ethanol reduces serotonin expression in the adult raphe nucleus and upregulates innate immune expression that is prevented by exercise.	Vetreno RP et al.	—	2017	→
Adolescents at risk for drug abuse: a 3-year dual-process analysis.	Ames SL et al.	—	2017	→
Alcohol consumption during adolescence is associated with reduced grey matter volumes.	Heikkinen N et al.	—	2017	→
Alcohol vapor exposure differentially impacts mesocorticolimbic cytokine expression in a sex-, region-, and duration-specific manner.	Baxter-Potter LN et al.	—	2017	→
Altered brain correlates of response inhibition and error processing in females with obesity and sweet food addiction: A functional magnetic imaging study.	Hsu JS et al.	—	2017	→
A one-week 5-choice serial reaction time task to measure impulsivity and attention in adult and adolescent mice.	Remmelink E et al.	—	2017	→
Aripiprazole Suppression of Drinking in a Clinical Laboratory Paradigm: Influence of Impulsivity and Self-Control.	Anton RF et al.	—	2017	→
Assessing the risk of marijuana use disorder among adolescents and adults who use marijuana.	Richter L et al.	—	2017	→
Associating resting-state connectivity with trait impulsivity.	Angelides NH et al.	—	2017	→
Association between Internet gaming disorder and adult attention deficit and hyperactivity disorder and their correlates: Impulsivity and hostility.	Yen JY et al.	—	2017	→
Binge alcohol alters exercise-driven neuroplasticity.	Barton EA et al.	—	2017	→
Dissociable Contributions of Imagination and Willpower to the Malleability of Human Patience.	Jenkins AC et al.	—	2017	→
Dissociable frontostriatal white matter connectivity underlies reward and motor impulsivity.	Hampton WH et al.	—	2017	→
Do alcohol-dependent patients show different neural activation during response inhibition than healthy controls in an alcohol-related fMRI go/no-go-task?	Czapla M et al.	—	2017	→
Dysregulated Glycine Signaling Contributes to Increased Impulsivity during Protracted Alcohol Abstinence.	Irimia C et al.	—	2017	→
Effect of Victimization on Impulse Control and Binge Drinking among Serious Juvenile Offenders from Adolescence to Young Adulthood.	Davis JP et al.	—	2017	→
Effects of Alcohol Dependence Severity on Neural Correlates of Delay Discounting.	Lim AC et al.	—	2017	→
Effects of binge drinking and hangover on response selection sub-processes-a study using EEG and drift diffusion modeling.	Stock AK et al.	—	2017	→
Effects of drinking patterns on prospective memory performance in college students.	Zamroziewicz M et al.	—	2017	→
Executive Functions and Performance Variability Measured by Event-Related Potentials to Understand the Neural Bases of Perceptual Decision-Making.	Perri RL et al.	—	2017	→
Gray Matter Abnormalities in the Inhibitory Circuitry of Young Binge Drinkers: A Voxel-Based Morphometry Study.	Sousa SS et al.	—	2017	→
Impact of juvenile chronic stress on adult cortico-accumbal function: Implications for cognition and addiction.	Watt MJ et al.	—	2017	→
Impulsive Rats Exhibit Blunted Dopamine Release Dynamics during a Delay Discounting Task Independent of Cocaine History.	Moschak TM et al.	—	2017	→
Long-term reliability and stability of behavioral measures among adolescents: The Delay Discounting and Stroop tasks.	Martínez-Loredo V et al.	—	2017	→
Neural impact of low-level alcohol use on response inhibition: An fMRI investigation in young adults.	Hatchard T et al.	—	2017	→
One-year sobriety improves satisfaction with life, executive functions and psychological distress among patients with polysubstance use disorder.	Hagen E et al.	—	2017	→
Orbitofrontal Neuroadaptations and Cross-Species Synaptic Biomarkers in Heavy-Drinking Macaques.	Nimitvilai S et al.	—	2017	→
Pilot Study of Endurance Runners and Brain Responses Associated with Delay Discounting.	Martin LE et al.	—	2017	→
Steep effort discounting of a preferred reward over a freely-available option in prolonged methamphetamine withdrawal in male rats.	Thompson AB et al.	—	2017	→
Testing interactive effects of automatic and conflict control processes during response inhibition - A system neurophysiological study.	Chmielewski WX et al.	—	2017	→
The ABCD study of neurodevelopment: Identifying neurocircuit targets for prevention and treatment of adolescent substance abuse.	Bjork JM et al.	—	2017	→
The procrastination of Internet gaming disorder in young adults: The clinical severity.	Yeh YC et al.	—	2017	→
The role of neuroimmune signaling in alcoholism.	Crews FT et al.	—	2017	→
Toll-like receptor signaling and stages of addiction.	Crews FT et al.	—	2017	→
Typology of Internet gaming disorder and its clinical implications.	Lee SY et al.	—	2017	→
White matter alterations in cocaine users are negatively related to the number of additionally (ab)used substances.	Kaag AM et al.	—	2017	→
White Matter Changes in HIV+ Women with a History of Cocaine Dependence.	Wakim KM et al.	—	2017	→
Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior.	Crews FT et al.	—	2016	→
Adolescent oxycodone self administration alters subsequent oxycodone-induced conditioned place preference and anti-nociceptive effect in C57BL/6J mice in adulthood.	Zhang Y et al.	—	2016	→
Adolescent transitions in reflexive and non-reflexive behavior: Review of fear conditioning and impulse control in rodent models.	Hunt PS et al.	—	2016	→
Alcohol dependence-induced regulation of the proliferation and survival of adult brain progenitors is associated with altered BDNF-TrkB signaling.	Somkuwar SS et al.	—	2016	→
Anodal Stimulation of the Left DLPFC Increases IGT Scores and Decreases Delay Discounting Rate in Healthy Males.	He Q et al.	—	2016	→
Brain Cortical Thickness Differences in Adolescent Females with Substance Use Disorders.	Boulos PK et al.	—	2016	→
Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity.	Li W et al.	—	2016	→
Chronic Cigarette Smoking in Healthy Middle-Aged Individuals Is Associated With Decreased Regional Brain N-acetylaspartate and Glutamate Levels.	Durazzo TC et al.	—	2016	→
Cognitive Decline and Recovery in Alcohol Abuse.	Perry CJ	—	2016	→
Cognitive Dysfunction, Affective States, and Vulnerability to Nicotine Addiction: A Multifactorial Perspective.	Besson M et al.	—	2016	→
Differential Improvement of Executive Functions During Abstinence in Cocaine-Dependent Patients: A Longitudinal Study.	Inozemtseva O et al.	—	2016	→
Distress Tolerance and Impulsivity Are Associated With Drug and Alcohol Use Consequences in an Online Community Sample.	Greenberg LP et al.	—	2016	→
Disturbances in Response Inhibition and Emotional Processing as Potential Pathways to Violence in Schizophrenia: A High-Density Event-Related Potential Study.	Krakowski MI et al.	—	2016	→
Frontal asymmetry and alcohol cue reactivity: Influence of core personality systems.	Mechin N et al.	—	2016	→
Future Directions in Childhood Adversity and Youth Psychopathology.	McLaughlin KA	—	2016	→
General Habit Propensity Relates to the Sensation Seeking Subdomain of Impulsivity But Not Obesity.	Dietrich A et al.	—	2016	→
High-dose alcohol intoxication differentially modulates cognitive subprocesses involved in response inhibition.	Stock AK et al.	—	2016	→
How to study sex differences in addiction using animal models.	Carroll ME et al.	—	2016	→
Impulsivity and Alcohol Dependence Treatment Completion: Is There a Neurocognitive Risk Factor at Treatment Entry?	Rupp CI et al.	—	2016	→
Increased Synaptic Excitation and Abnormal Dendritic Structure of Prefrontal Cortex Layer V Pyramidal Neurons following Prolonged Binge-Like Consumption of Ethanol.	Klenowski PM et al.	—	2016	→
Influence of the Novelty-Seeking Endophenotype on the Rewarding Effects of Psychostimulant Drugs in Animal Models.	Arenas MC et al.	—	2016	→
Neural Correlates of Response Inhibition in Adolescents Prospectively Predict Regular Tobacco Smoking.	Anokhin AP et al.	—	2016	→
Neural predictors of alcohol use and psychopathology symptoms in adolescents.	Brumback TY et al.	—	2016	→
Neurobiology of Adolescent Substance Use Disorders.	Sharma A et al.	—	2016	→
Novel GRN Mutations in Patients with Corticobasal Syndrome.	Taghdiri F et al.	—	2016	→
On the relationship between response selection and response inhibition: An individual differences approach.	Bender AD et al.	—	2016	→
Paradox effects of binge drinking on response inhibition processes depending on mental workload.	Stock AK et al.	—	2016	→
Perspectives on neurocognitive rehabilitation as an adjunct treatment for addictive disorders: From cognitive improvement to relapse prevention.	Rezapour T et al.	—	2016	→
Prior Binge Ethanol Exposure Potentiates the Microglial Response in a Model of Alcohol-Induced Neurodegeneration.	Marshall SA et al.	—	2016	→
Proactive inhibitory control: A general biasing account.	Elchlepp H et al.	—	2016	→
Relations Between Cognitive Functioning and Alcohol Use, Craving, and Post-Traumatic Stress: An Examination Among Trauma-Exposed Military Veterans With Alcohol Use Disorder.	Heinz AJ et al.	—	2016	→
Reliability of the GAIN-SS, CRAFTT and PESQ screening instruments for substance use among South African adolescents.	Carney T et al.	—	2016	→
Residual Effects: Young Adult Diagnostic Drinking Predicts Late-Life Health Outcomes.	Haber JR et al.	—	2016	→
Self-deception as affective coping. An empirical perspective on philosophical issues.	Lauria F et al.	—	2016	→
Self-regulation interventions to reduce consumption of sugar-sweetened beverages in adolescents.	Ames SL et al.	—	2016	→
Sensation seeking and executive deficits in relation to alcohol, tobacco, and marijuana use frequency among university students: Value of ecologically based measures.	Meil WM et al.	—	2016	→
Sex differences in the relationship between heavy alcohol use, inhibition and performance monitoring: Disconnect between behavioural and brain functional measures.	Smith JL et al.	—	2016	→
Should I stop or should I go? The role of associations and expectancies.	Best M et al.	—	2016	→
The impact of cognitive impairment and impulsivity on relapse of alcohol-dependent patients: implications for psychotherapeutic treatment.	Czapla M et al.	—	2016	→
Treatment Utilization Among Adolescent Substance Users: Findings from the 2002 to 2013 National Survey on Drug Use and Health.	Haughwout SP et al.	—	2016	→
Underage drinking: prevalence and correlates of risky drinking measures among youth aged 12-20.	Richter L et al.	—	2016	→
Using Dual Process Models to Examine Impulsivity Throughout Neural Maturation.	Leshem R	—	2016	→
Withdrawal from Chronic Nicotine Exposure Produces Region-Specific Tolerance to Alcohol-Stimulated GluA1 Phosphorylation.	McGinn MA et al.	—	2016	→
Aggressive behavior among military veterans in substance use disorder treatment: the roles of posttraumatic stress and impulsivity.	Heinz AJ et al.	—	2015	→
A hypothesis about how early developmental methylmercury exposure disrupts behavior in adulthood.	Newland MC et al.	—	2015	→
Alcohol use across the lifespan: An analysis of adolescent and aged rodents and humans.	Novier A et al.	—	2015	→
Alleviating waiting impulsivity and perseverative responding by μ-opioid receptor antagonism in two inbred mouse strains.	Sanchez-Roige S et al.	—	2015	→
Altered gray matter density and disrupted functional connectivity of the amygdala in adults with Internet gaming disorder.	Ko CH et al.	—	2015	→
Brain correlates of response inhibition in Internet gaming disorder.	Chen CY et al.	—	2015	→
Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features.	Kamarajan C et al.	—	2015	→
Distinct facets of impulsivity exhibit differential associations with substance use disorder treatment processes: a cross-sectional and prospective investigation among military veterans.	Heinz AJ et al.	—	2015	→
Evaluating Exercise as a Therapeutic Intervention for Methamphetamine Addiction-Like Behavior.	Somkuwar SS et al.	—	2015	→
Exploratory Analysis of Power Spectrum and Functional Connectivity During Resting State in Young Binge Drinkers: A MEG Study.	Correas A et al.	—	2015	→
Family history of alcoholism and brain activation: commentary on "Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/No-Go task".	Colrain IM	—	2015	→
Female but not male young heavy drinkers display altered performance monitoring.	Smith JL et al.	—	2015	→
Fronto-temporal white matter connectivity predicts reversal learning errors.	Alm KH et al.	—	2015	→
Functional coherence of insula networks is associated with externalizing behavior.	Abram SV et al.	—	2015	→
Impulsivity is Associated with Increased Metabolism in the Fronto-Insular Network in Parkinson's Disease.	Tahmasian M et al.	—	2015	→
Is binge drinking in young adults associated with an alcohol-specific impairment of response inhibition?	Czapla M et al.	—	2015	→
Model of voluntary ethanol intake in zebrafish: effect on behavior and hypothalamic orexigenic peptides.	Sterling ME et al.	—	2015	→
Modification of EEG functional connectivity and EEG power spectra in overweight and obese patients with food addiction: An eLORETA study.	Imperatori C et al.	—	2015	→
Neural mechanisms of high-risk decisions-to-drink in alcohol-dependent women.	Arcurio LR et al.	—	2015	→
Neuroimmune Function and the Consequences of Alcohol Exposure.	Crews FT et al.	—	2015	→
New developments on the neurobiological and pharmaco-genetic mechanisms underlying internet and videogame addiction.	Weinstein A et al.	—	2015	→
Religiosity and Impulsivity in Mental Health: Is There a Relationship?	Caribé AC et al.	—	2015	→
Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task.	Kamarajan C et al.	—	2015	→
Sex Differences in Behavioral Dyscontrol: Role in Drug Addiction and Novel Treatments.	Carroll ME et al.	—	2015	→
Study of the analgesic activities, chronic toxicity and addictive potential of Jia-Yuan-Qing pill in rats.	Tian YE et al.	—	2015	→
The genetics of impulsivity: evidence for the heritability of delay discounting.	Anokhin AP et al.	—	2015	→
Two clusters of child molesters based on impulsiveness.	Baltieri DA et al.	—	2015	→
Withdrawal from chronic intermittent alcohol exposure increases dendritic spine density in the lateral orbitofrontal cortex of mice.	McGuier NS et al.	—	2015	→
Adolescent, but not adult, binge ethanol exposure leads to persistent global reductions of choline acetyltransferase expressing neurons in brain.	Vetreno RP et al.	—	2014	→
[Alcohol induced cognitive deficits].	Weiss E et al.	—	2014	→
Banishing the Control Homunculi in Studies of Action Control and Behavior Change.	Verbruggen F et al.	—	2014	→
Chronic alcohol intake during adolescence, but not adulthood, promotes persistent deficits in risk-based decision making.	Schindler AG et al.	—	2014	→
Cognitive control in alcohol use disorder: deficits and clinical relevance.	Wilcox CE et al.	—	2014	→
Construct validity of adolescents' self-reported big five personality traits: importance of conceptual breadth and initial validation of a short measure.	Morizot J	—	2014	→
Current hypotheses on the mechanisms of alcoholism.	Vetreno RP et al.	—	2014	→
Differential sensitivity of prefrontal cortex and hippocampus to alcohol-induced toxicity.	Fowler AK et al.	—	2014	→
Dissecting impulsivity and its relationships to drug addictions.	Jentsch JD et al.	—	2014	→
Dysfunctional inhibitory control and impulsivity in Internet addiction.	Choi JS et al.	—	2014	→
Effectively addressing addiction requires changing the language of addiction.	Richter L et al.	—	2014	→
Effects of amphetamine exposure in adolescence or young adulthood on inhibitory control in adult male and female rats.	Hammerslag LR et al.	—	2014	→
Effects of stress and dietary tryptophan enhancement on craving for alcohol in binge and non-binge heavy drinkers.	Nesic J et al.	—	2014	→
fMRI response during figural memory task performance in college drinkers.	Dager AD et al.	—	2014	→
Functional imaging of an alcohol-Implicit Association Test (IAT).	Ames SL et al.	—	2014	→
Impaired response inhibition in the rat 5 choice continuous performance task during protracted abstinence from chronic alcohol consumption.	Irimia C et al.	—	2014	→
Impulsivity and comorbid traits: a multi-step approach for finding putative responsible microRNAs in the amygdala.	Pietrzykowski AZ et al.	—	2014	→
Impulsivity moderates the association between physical activity and alcohol consumption.	Leasure JL et al.	—	2014	→
Increased response conflict in recreational cocaine polydrug users.	Sellaro R et al.	—	2014	→
Inhibitory control effects in adolescent binge eating and consumption of sugar-sweetened beverages and snacks.	Ames SL et al.	—	2014	→
Interactive effects of chronic cigarette smoking and age on brain volumes in controls and alcohol-dependent individuals in early abstinence.	Durazzo TC et al.	—	2014	→
Modulation of risky choices in recently abstinent dependent cocaine users: a transcranial direct-current stimulation study.	Gorini A et al.	—	2014	→
Neural correlates of a Go/NoGo task with alcohol stimuli in light and heavy young drinkers.	Ames SL et al.	—	2014	→
Neurocircuitry of alcohol addiction: synthesis from animal models.	Koob GF	—	2014	→
Neuroimmune basis of alcoholic brain damage.	Crews FT et al.	—	2014	→
Partial inactivation of nucleus accumbens core decreases delay discounting in rats without affecting sensitivity to delay or magnitude.	Moschak TM et al.	—	2014	→
Perspectives on the neuroscience of alcohol from the National Institute on Alcohol Abuse and Alcoholism.	Reilly MT et al.	—	2014	→
Pharmacological and clinical dilemmas of prescribing in co-morbid adult attention-deficit/hyperactivity disorder and addiction.	Pérez de los Cobos J et al.	—	2014	→
Profiles of impaired, spared, and recovered neuropsychologic processes in alcoholism.	Oscar-Berman M et al.	—	2014	→
Relationship between impulsivity, prefrontal anticipatory activation, and striatal dopamine release during rewarded task performance.	Weiland BJ et al.	—	2014	→
Relationship between trait impulsivity and cortical volume, thickness and surface area in male cocaine users and non-drug using controls.	Kaag AM et al.	—	2014	→
Role of microglia in regulation of ethanol neurotoxic action.	Chastain LG et al.	—	2014	→
Role of NG2 expressing cells in addiction: a new approach for an old problem.	Somkuwar SS et al.	—	2014	→
Substance abuse risk in emerging adults associated with smaller frontal gray matter volumes and higher externalizing behaviors.	Weiland BJ et al.	—	2014	→
The association between premenstrual dysphoric disorder and internet use disorder.	Ko CH et al.	—	2014	→
The development of a brief self-report questionnaire to measure 'recent' rash impulsivity: a preliminary investigation of its validity and association with recent alcohol consumption.	Mayhew MJ et al.	—	2014	→
The effects of acute alcohol administration on the human brain: insights from neuroimaging.	Bjork JM et al.	—	2014	→
Theory of mind among young adult children from alcoholic families.	Kopera M et al.	—	2014	→
Treatment of methamphetamine-induced psychosis: a double-blind randomized controlled trial comparing haloperidol and quetiapine.	Verachai V et al.	—	2014	→
Why adolescents are at risk of misusing alcohol and gambling.	Noël X	—	2014	→
Approach bias modification in alcohol dependence: do clinical effects replicate and for whom does it work best?	Eberl C et al.	—	2013	→
Are the effects of response inhibition on gambling long-lasting?	Verbruggen F et al.	—	2013	→
Chronic cigarette smoking in alcohol dependence: associations with cortical thickness and N-acetylaspartate levels in the extended brain reward system.	Durazzo TC et al.	—	2013	→
Cocaine self-administration behavior in inbred mouse lines segregating different capacities for inhibitory control.	Cervantes MC et al.	—	2013	→
Controversies about the enhanced vulnerability of the adolescent brain to develop addiction.	Bernheim A et al.	—	2013	→
Developmental disruption of gamma-aminobutyric acid function in the medial prefrontal cortex by noncontingent cocaine exposure during early adolescence.	Cass DK et al.	—	2013	→
Diffusion tensor imaging of white matter networks in individuals with current and remitted alcohol use disorders and comorbid conditions.	Monnig MA et al.	—	2013	→
Dissociable effects of kappa-opioid receptor activation on impulsive phenotypes in wistar rats.	Walker BM et al.	—	2013	→
Effects of intoxicating free-choice alcohol consumption during adolescence on drinking and impulsivity during adulthood in selectively bred high-alcohol preferring mice.	O'Tousa DS et al.	—	2013	→
Effects of the Youth Empowerment Seminar on impulsive behavior in adolescents.	Ghahremani DG et al.	—	2013	→
Exercise enhances hippocampal recovery following binge ethanol exposure.	Maynard ME et al.	—	2013	→
Familial, social, and individual factors contributing to risk for adolescent substance use.	Whitesell M et al.	—	2013	→
Fluctuating disinhibition: implications for the understanding and treatment of alcohol and other substance use disorders.	Jones A et al.	—	2013	→
Gene expression in brain and liver produced by three different regimens of alcohol consumption in mice: comparison with immune activation.	Osterndorff-Kahanek E et al.	—	2013	→
High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence.	Crews FT et al.	—	2013	→
Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: The importance of microglia phenotype.	Marshall SA et al.	—	2013	→
Periadolescent ethanol vapor exposure persistently reduces measures of hippocampal neurogenesis that are associated with behavioral outcomes in adulthood.	Ehlers CL et al.	—	2013	→
Peri-adolescent ethanol vapor exposure produces reductions in hippocampal volume that are correlated with deficits in prepulse inhibition of the startle.	Ehlers CL et al.	—	2013	→
Readiness to change and brain damage in patients with chronic alcoholism.	Le Berre AP et al.	—	2013	→
Relationship of age to impulsivity and decision making: a baseline secondary analysis of a behavioral treatment study in stimulant use disorders.	Kalapatapu RK et al.	—	2013	→
Reversed scototaxis during withdrawal after daily-moderate, but not weekly-binge, administration of ethanol in zebrafish.	Holcombe A et al.	—	2013	→
Systemic administration of low dosage of tetanus toxin decreases cell proliferation and neuroblast differentiation in the mouse hippocampal dentate gyrus.	Yan BC et al.	—	2013	→
The concepts of rash impulsiveness and reward sensitivity in substance use disorders.	Boog M et al.	—	2013	→
The role of negative emotionality and impulsivity in depressive/anxiety disorders and alcohol dependence.	Boschloo L et al.	—	2013	→
Time-based prospective memory predicts engagement in risk behaviors among substance users: results from clinical and nonclinical samples.	Weinborn M et al.	—	2013	→
Upregulated dynorphin opioid peptides mediate alcohol-induced learning and memory impairment.	Kuzmin A et al.	—	2013	→
A critical look at the relationship between impulsivity and decision-making in adolescents: are they related or separate factors?	Leshem R et al.	—	2012	→
Alcohol dependence associated with increased utilitarian moral judgment: a case control study.	Khemiri L et al.	—	2012	→
Alcohol-induced one-carbon metabolism impairment promotes dysfunction of DNA base excision repair in adult brain.	Fowler AK et al.	—	2012	→
A modified adjusting delay task to assess impulsive choice between isocaloric reinforcers in non-deprived male rats: effects of 5-HT₂A/C and 5-HT₁A receptor agonists.	Blasio A et al.	—	2012	→
Are executive function and impulsivity antipodes? A conceptual reconstruction with special reference to addiction.	Bickel WK et al.	—	2012	→
Cognitive barriers to readiness to change in alcohol-dependent patients.	Le Berre AP et al.	—	2012	→
Decision-making deficit in chronic migraine patients with medication overuse.	Biagianti B et al.	—	2012	→
Differences between smokers and non-smokers in regional gray matter volumes: a voxel-based morphometry study.	Liao Y et al.	—	2012	→
Disordered neighborhood environments and risk-taking propensity in late childhood through adolescence.	Furr-Holden CD et al.	—	2012	→
Drug-related cues exacerbate decision making and increase craving in heroin addicts at different abstinence times.	Wang GB et al.	—	2012	→
Executive functioning and alcohol binge drinking in university students.	Parada M et al.	—	2012	→
Impulsivity differences in recreational cannabis users and binge drinkers in a university population.	Moreno M et al.	—	2012	→
NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration.	Qin L et al.	—	2012	→
Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry.	Archer T et al.	—	2012	→
Orbitofrontal dysfunction and medication overuse in patients with migraine.	Biagianti B et al.	—	2012	→
Phasic nucleus accumbens dopamine encodes risk-based decision-making behavior.	Sugam JA et al.	—	2012	→
Proactive motor control reduces monetary risk taking in gambling.	Verbruggen F et al.	—	2012	→
Repeated moderate-dose ethanol bouts impair cognitive function in Wistar rats.	Kuzmin A et al.	—	2012	→
Responses to novelty and vulnerability to cocaine addiction: contribution of a multi-symptomatic animal model.	Belin D et al.	—	2012	→
Reversal learning as a measure of impulsive and compulsive behavior in addictions.	Izquierdo A et al.	—	2012	→
Substrates of neuropsychological functioning in stimulant dependence: a review of functional neuroimaging research.	Crunelle CL et al.	—	2012	→
Targeting dynorphin/kappa opioid receptor systems to treat alcohol abuse and dependence.	Walker BM et al.	—	2012	→
Taste, olfactory and food texture reward processing in the brain and the control of appetite.	Rolls ET	—	2012	→
The effect of morphine dependence on impulsive choice in rats.	Harvey-Lewis C et al.	—	2012	→
Topography, power, and current source density of θ oscillations during reward processing as markers for alcohol dependence.	Kamarajan C et al.	—	2012	→
Addiction, adolescence, and the integration of control and motivation.	Gladwin TE et al.	—	2011	→
Adolescent substance abuse: the effects of alcohol and marijuana on neuropsychological performance.	Thoma RJ et al.	—	2011	→
Advances in animal models of drug addiction.	Heidbreder C	—	2011	→
A neurochemical yin and yang: does serotonin activate and norepinephrine deactivate the prefrontal cortex?	Fitzgerald PJ	—	2011	→
Antipsychotic treatment of adolescent dual diagnosis patients.	Price SA et al.	—	2011	→
Association of frontal and posterior cortical gray matter volume with time to alcohol relapse: a prospective study.	Rando K et al.	—	2011	→
Cognitive neuroscience of self-regulation failure.	Heatherton TF et al.	—	2011	→
Effects of premature birth on the risk for alcoholism appear to be greater in males than females.	Manzardo AM et al.	—	2011	→
Evidence that 'food addiction' is a valid phenotype of obesity.	Davis C et al.	—	2011	→
Frontally mediated inhibitory processing and white matter microstructure: age and alcoholism effects.	Colrain IM et al.	—	2011	→
Genetic dissection of behavioral flexibility: reversal learning in mice.	Laughlin RE et al.	—	2011	→
Individual differences in local gray and white matter volumes reflect differences in temperament and character: a voxel-based morphometry study in healthy young females.	Van Schuerbeek P et al.	—	2011	→
Methamphetamine-induced locomotor changes are dependent on age, dose and genotype.	Good RL et al.	—	2011	→
Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain.	Alfonso-Loeches S et al.	—	2011	→
N4 component responses to pre-pulse startle stimuli in young adults: relationship to alcohol dependence.	Ehlers CL et al.	—	2011	→
Periadolescent ethanol exposure reduces adult forebrain ChAT+IR neurons: correlation with behavioral pathology.	Ehlers CL et al.	—	2011	→
Reduced cortical gray matter volume in male adolescents with substance and conduct problems.	Dalwani M et al.	—	2011	→
Reduced dorsal prefrontal gray matter after chronic ketamine use.	Liao Y et al.	—	2011	→
Repeated co-administrations of alcohol- and methamphetamine-produced anxiogenic effect could be associated with the neurotoxicity in the dentate gyrus.	Chuang JY et al.	—	2011	→
Repeated exposure to moderate doses of ethanol augments hippocampal glutamate neurotransmission by increasing release.	Chefer V et al.	—	2011	→
Stress and alcohol cues exert conjoint effects on go and stop signal responding in male problem drinkers.	Zack M et al.	—	2011	→
Taste, olfactory and food texture reward processing in the brain and obesity.	Rolls ET	—	2011	→
Adolescence as a critical window for developing an alcohol use disorder: current findings in neuroscience.	Nixon K et al.	—	2010	→
A method for mapping intralocus interactions influencing excessive alcohol drinking.	Phillips TJ et al.	—	2010	→
A new test to measure attentional bias and cognitive disinhibition in drinkers, based on the Hayling task.	Rose AK et al.	—	2010	→
Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.	Olive MF	—	2010	→
Cortical perfusion in alcohol-dependent individuals during short-term abstinence: relationships to resumption of hazardous drinking after treatment.	Durazzo TC et al.	—	2010	→
Delay discounting behavior and white matter microstructure abnormalities in youth with a family history of alcoholism.	Herting MM et al.	—	2010	→
EEG alpha phenotypes: linkage analyses and relation to alcohol dependence in an American Indian community study.	Ehlers CL et al.	—	2010	→
Effects of repeated withdrawal from alcohol on recovery of cognitive impairment under abstinence and rate of relapse.	Loeber S et al.	—	2010	→
Glutamatergic targets for enhancing extinction learning in drug addiction.	Cleva RM et al.	—	2010	→
Heterogeneity of reward mechanisms.	Lajtha A et al.	—	2010	→
Impulsivity, impulsive and reflective processes and the development of alcohol use and misuse in adolescents and young adults.	Wiers RW et al.	—	2010	→
Metabolite levels in the brain reward pathway discriminate those who remain abstinent from those who resume hazardous alcohol consumption after treatment for alcohol dependence.	Durazzo TC et al.	—	2010	→
Protein kinase C isozymes as regulators of sensitivity to and self-administration of drugs of abuse-studies with genetically modified mice.	Olive MF et al.	—	2010	→
Recruitment of additional brain regions to accomplish simple motor tasks in chronic alcohol-dependent patients.	Parks MH et al.	—	2010	→
Special issue in honor of professor Armen Galoyan. Preface.	Lajtha A	—	2010	→
The Effects of Naltrexone Among Alcohol Non-Abstainers: Results from the COMBINE Study.	Ray LA et al.	—	2010	→
The emergence of gonadal hormone influences on dopaminergic function during puberty.	Kuhn C et al.	—	2010	→