Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats.
paper
Cited
Public
Unavailable
- Authors
- Crews, F T; Braun, C J; Hoplight, B; Switzer, R C; Knapp, D J
- Year
- 2000
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 11104119
BACKGROUND: Adolescents respond differently to alcohol than adults. Furthermore, binge drinking in young adolescents is becoming increasingly common. METHODS: To determine if the effects of binge drinking on brain damage are different in juveniles compared with adults, the effects of a 4 day binge ethanol treatment (e.g., 4 days of 4 times per day 15% ethanol intragastrically, approximately 9-10 g/kg/day ethanol) were investigated in adolescent-juvenile rats (JVN) 35 days old and compared with adult (ADT) rats 80 to 90 days old. Brain damage was measured by using the amino cupric silver stain of de Olmos et al. (1994). RESULTS: Significant brain damage was found in both groups. The olfactory bulbs were equally damaged in both groups; however, the associated frontal cortical olfactory regions were damaged only in JVN. The anterior portions of the piriform and perirhinal cortices also were damaged only in JVN rats. Quantitation of silver-stained frontal areas in binge ethanol-treated JVN rats ranged from 400% to 1,260% of control values. For example, in anterior perirhinal cortex, silver stain increased from 48 +/- 14 to 444 +/- 114 (mm2 x 10(3) argyrophilic area; p < 0.01) in JVN control and binge ethanol-treated animals, respectively. In contrast, posterior perirhinal cortex showed greater damage in adults, being 236 +/- 76 vs. 875 +/- 135 (mm2 x 10(3) argyrophilic area; p < 0.005) in JVN and ADT, respectively. CONCLUSIONS: The young-adolescent brain shows differential sensitivity to alcohol-induced brain damage compared with adults.
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| Brain structure in adolescents and young adults with alcohol problems: systematic review of imaging studies. | Welch KA et al. | โ | 2013 | โ |
| Chronic binge-like alcohol consumption in adolescence causes depression-like symptoms possibly mediated by the effects of BDNF on neurogenesis. | Briones TL et al. | โ | 2013 | โ |
| Consequences of ethanol exposure on cued and contextual fear conditioning and extinction differ depending on timing of exposure during adolescence or adulthood. | Broadwater M et al. | โ | 2013 | โ |
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| Differences in brain activity during a verbal associative memory encoding task in high- and low-fit adolescents. | Herting MM et al. | โ | 2013 | โ |
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| Effects of intoxicating free-choice alcohol consumption during adolescence on drinking and impulsivity during adulthood in selectively bred high-alcohol preferring mice. | O'Tousa DS et al. | โ | 2013 | โ |
| Effects of rearing conditions on behaviour and endogenous opioids in rats with alcohol access during adolescence. | Palm S et al. | โ | 2013 | โ |
| Effects of voluntary access to sweetened ethanol during adolescence on intake in adulthood. | Broadwater M et al. | โ | 2013 | โ |
| Fluctuating disinhibition: implications for the understanding and treatment of alcohol and other substance use disorders. | Jones A et al. | โ | 2013 | โ |
| Juvenile ethanol exposure increases rewarding properties of cocaine and morphine in adult DBA/2J mice. | Molet J et al. | โ | 2013 | โ |
| Long-term effects of chronic intermittent ethanol exposure in adolescent and adult rats: radial-arm maze performance and operant food reinforced responding. | Risher ML et al. | โ | 2013 | โ |
| Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: The importance of microglia phenotype. | Marshall SA et al. | โ | 2013 | โ |
| Multiple behavioural impulsivity tasks predict prospective alcohol involvement in adolescents. | Fernie G et al. | โ | 2013 | โ |
| Pathways to alcohol-induced brain impairment in young people: a review. | Hermens DF et al. | โ | 2013 | โ |
| Similar ethanol drinking in adolescent and adult C57BL/6J mice after chronic ethanol exposure and withdrawal. | Carrara-Nascimento PF et al. | โ | 2013 | โ |
| STP position paper: Recommended practices for sampling and processing the nervous system (brain, spinal cord, nerve, and eye) during nonclinical general toxicity studies. | Bolon B et al. | โ | 2013 | โ |
| The acute effects of alcohol on sleep architecture in late adolescence. | Chan JK et al. | โ | 2013 | โ |
| The developmental psychopathology of alcohol use and alcohol disorders: research achievements and future directions. | Chassin L et al. | โ | 2013 | โ |
| The effects of abused drugs on adolescent development of corticolimbic circuitry and behavior. | Gulley JM et al. | โ | 2013 | โ |
| Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder. | Liput DJ et al. | โ | 2013 | โ |
| Working memory ability predicts trajectories of early alcohol use in adolescents: the mediational role of impulsivity. | Khurana A et al. | โ | 2013 | โ |
| Adolescent binge drinking increases expression of the danger signal receptor agonist HMGB1 and Toll-like receptors in the adult prefrontal cortex. | Vetreno RP et al. | โ | 2012 | โ |
| Alcohol-related brain damage: report from a Medical Council on Alcohol Symposium, June 2010. | Thomson AD et al. | โ | 2012 | โ |
| A mouse model for adolescent alcohol abuse: stunted growth and effects in brain. | Huang C et al. | โ | 2012 | โ |
| A prospective study of sexual assault and alcohol use among first-year college women. | Mouilso ER et al. | โ | 2012 | โ |
| Attention, impulsivity, and cognitive flexibility in adult male rats exposed to ethanol binge during adolescence as measured in the five-choice serial reaction time task: the effects of task and ethanol challenges. | Semenova S | โ | 2012 | โ |
| Early attentional modulation by alcohol-related cues in young binge drinkers: an event-related potentials study. | Petit G et al. | โ | 2012 | โ |
| Effect of intermittent exposure to ethanol and MDMA during adolescence on learning and memory in adult mice. | Vidal-Infer A et al. | โ | 2012 | โ |
| Effects of ethanol during adolescence on the number of neurons and glia in the medial prefrontal cortex and basolateral amygdala of adult male and female rats. | Koss WA et al. | โ | 2012 | โ |
| Executive functioning and alcohol binge drinking in university students. | Parada M et al. | โ | 2012 | โ |
| High-risk driving behaviors among adolescent binge drinkers. | Marcotte TD et al. | โ | 2012 | โ |
| Hyperactivation of right inferior frontal cortex in young binge drinkers during response inhibition: a follow-up study. | Lรณpez-Caneda E et al. | โ | 2012 | โ |
| Impulsivity and alcohol consumption in young social drinkers. | Henges AL et al. | โ | 2012 | โ |
| Increased amplitude of P3 event-related potential in young binge drinkers. | Crego A et al. | โ | 2012 | โ |
| Inflammasome-IL-1ฮฒ Signaling Mediates Ethanol Inhibition of Hippocampal Neurogenesis. | Zou J et al. | โ | 2012 | โ |
| In the rat, chronic intermittent ethanol exposure during adolescence alters the ethanol sensitivity of tonic inhibition in adulthood. | Fleming RL et al. | โ | 2012 | โ |
| Mephedrone (4-methylmethcathinone, 'meow'): acute behavioural effects and distribution of Fos expression in adolescent rats. | Motbey CP et al. | โ | 2012 | โ |
| NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration. | Qin L et al. | โ | 2012 | โ |
| Repeated ethanol but not phencyclidine impairs spontaneous alternation behaviour in the Y-maze. | Gรถtesson J et al. | โ | 2012 | โ |
| Supplemental choline during the periweaning period protects against trace conditioning impairments attributable to post-training ethanol exposure in adolescent rats. | Hunt PS | โ | 2012 | โ |
| Talking about alcohol consumption: health campaigns, conversational valence, and binge drinking intentions. | Hendriks H et al. | โ | 2012 | โ |
| The contribution of executive functions deficits to impaired episodic memory in individuals with alcoholism. | Noรซl X et al. | โ | 2012 | โ |
| Adolescent alcohol exposure alters the central brain circuits known to regulate the stress response. | Allen CD et al. | โ | 2011 | โ |
| Adolescent alcohol intoxication in Dutch hospital centers of pediatrics: characteristics and gender differences. | Bouthoorn SH et al. | โ | 2011 | โ |
| Adolescent binge alcohol exposure alters hippocampal progenitor cell proliferation in rats: effects on cell cycle kinetics. | McClain JA et al. | โ | 2011 | โ |
| Adolescent binge alcohol exposure induces long-lasting partial activation of microglia. | McClain JA et al. | โ | 2011 | โ |
| Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice. | Coleman LG et al. | โ | 2011 | โ |
| Adolescent neurobehavioral characteristics, alcohol sensitivities, and intake: Setting the stage for alcohol use disorders? | Spear LP | โ | 2011 | โ |
| Adolescent substance abuse: the effects of alcohol and marijuana on neuropsychological performance. | Thoma RJ et al. | โ | 2011 | โ |
| Alcohol intoxication among Dutch adolescents: acute medical complications in the years 2000-2010. | Bouthoorn SH et al. | โ | 2011 | โ |
| Associations between heavy drinking and changes in impulsive behavior among adolescent boys. | White HR et al. | โ | 2011 | โ |
| Brain renin-angiotensin--a new look at an old system. | Wright JW et al. | โ | 2011 | โ |
| Changes in neuropsychological functioning over 10 years following adolescent substance abuse treatment. | Hanson KL et al. | โ | 2011 | โ |
| Chronic alcohol consumption impairs visuo-spatial associative memory in periadolescent rhesus monkeys. | Crean RD et al. | โ | 2011 | โ |
| Chronic alcohol exposure induced gene expression changes in the zebrafish brain. | Pan Y et al. | โ | 2011 | โ |
| Chronic intermittent ethanol exposure in early adolescent and adult male rats: effects on tolerance, social behavior, and ethanol intake. | Broadwater M et al. | โ | 2011 | โ |
| Differential effects of post-weaning juvenile stress on the behaviour of C57BL/6 mice in adolescence and adulthood. | Peleg-Raibstein D et al. | โ | 2011 | โ |
| Early environmental factors differentially affect voluntary ethanol consumption in adolescent and adult male rats. | Daoura L et al. | โ | 2011 | โ |
| Effect of alcohol consumption in prenatal life, childhood, and adolescence on child development. | Foltran F et al. | โ | 2011 | โ |
| Effects of exogenous agents on brain development: stress, abuse and therapeutic compounds. | Archer T | โ | 2011 | โ |
| Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats. | Allen CD et al. | โ | 2011 | โ |
| Induction of innate immune genes in brain create the neurobiology of addiction. | Crews FT et al. | โ | 2011 | โ |
| Intermittent ethanol exposure increases long-lasting behavioral and neurochemical effects of MDMA in adolescent mice. | Rodrรญguez-Arias M et al. | โ | 2011 | โ |
| Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. | Alfonso-Loeches S et al. | โ | 2011 | โ |
| Recommended neuroanatomical sampling practices for comprehensive brain evaluation in nonclinical safety studies. | Switzer RC et al. | โ | 2011 | โ |
| Repeated co-administrations of alcohol- and methamphetamine-produced anxiogenic effect could be associated with the neurotoxicity in the dentate gyrus. | Chuang JY et al. | โ | 2011 | โ |
| Unique brain areas associated with abstinence control are damaged in multiply detoxified alcoholics. | Duka T et al. | โ | 2011 | โ |
| Upregulated vimentin suggests new areas of neurodegeneration in a model of an alcohol use disorder. | Kelso ML et al. | โ | 2011 | โ |
| Adolescence as a critical window for developing an alcohol use disorder: current findings in neuroscience. | Nixon K et al. | โ | 2010 | โ |
| Alcohol inhibition of neurogenesis: a mechanism of hippocampal neurodegeneration in an adolescent alcohol abuse model. | Morris SA et al. | โ | 2010 | โ |
| Alcohol response and consumption in adolescent rhesus macaques: life history and genetic influences. | Schwandt ML et al. | โ | 2010 | โ |
| Brain injury and recovery following binge ethanol: evidence from in vivo magnetic resonance spectroscopy. | Zahr NM et al. | โ | 2010 | โ |
| Consilient research approaches in studying gene x environment interactions in alcohol research. | Sher KJ et al. | โ | 2010 | โ |
| Drinking against unpleasant emotions: possible outcome of early onset of alcohol use? | Buchmann AF et al. | โ | 2010 | โ |
| Effects of ethanol on hippocampal function during adolescence: a look at the past and thoughts on the future. | Chin VS et al. | โ | 2010 | โ |
| Exercise neuroprotection in a rat model of binge alcohol consumption. | Leasure JL et al. | โ | 2010 | โ |
| Gender differences in the relationship between white matter organization and adolescent substance use disorders. | Thatcher DL et al. | โ | 2010 | โ |
| Long-term modulations in the vertebral transcriptome of adolescent-stage rats exposed to binge alcohol. | Callaci JJ et al. | โ | 2010 | โ |
| Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence. | Guerri C et al. | โ | 2010 | โ |
| Neurocircuitry of emotion and cognition in alcoholism: contributions from white matter fiber tractography. | Schulte T et al. | โ | 2010 | โ |
| Recreational drug use and impulsivity in a population of canadian undergraduate drinkers. | Balodis IM et al. | โ | 2010 | โ |
| Repeated binge ethanol administration during adolescence enhances voluntary sweetened ethanol intake in young adulthood in male and female rats. | Maldonado-Devincci AM et al. | โ | 2010 | โ |
| Research on alcohol and adolescent brain development: opportunities and future directions. | Witt ED | โ | 2010 | โ |
| Reversibility of object recognition but not spatial memory impairment following binge-like alcohol exposure in rats. | Cippitelli A et al. | โ | 2010 | โ |
| Risky alcohol use and heavy episodic drinking among Spanish University students: a two-year follow-up. | Mota N et al. | โ | 2010 | โ |
| Roles of neural stem cells and adult neurogenesis in adolescent alcohol use disorders. | Nixon K et al. | โ | 2010 | โ |
| Similar withdrawal severity in adolescents and adults in a rat model of alcohol dependence. | Morris SA et al. | โ | 2010 | โ |
| Suicidal behavior and alcohol abuse. | Pompili M et al. | โ | 2010 | โ |
| A developmental perspective on underage alcohol use. | Masten AS et al. | โ | 2009 | โ |
| Alcohol environments and disparities in exposure associated with adolescent drinking in California. | Truong KD et al. | โ | 2009 | โ |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | โ | 2009 | โ |
| Altered white matter integrity in adolescent binge drinkers. | McQueeny T et al. | โ | 2009 | โ |
| Behavioural measures of frontal lobe function in a population of young social drinkers with binge drinking pattern. | Scaife JC et al. | โ | 2009 | โ |
| Binge drinking affects attentional and visual working memory processing in young university students. | Crego A et al. | โ | 2009 | โ |
| Binge drinking in undergraduates: relationships with sex, drinking behaviors, impulsivity, and the perceived effects of alcohol. | Balodis IM et al. | โ | 2009 | โ |
| Binge drinking in young adults: Data, definitions, and determinants. | Courtney KE et al. | โ | 2009 | โ |
| Binge ethanol-induced neurodegeneration in rat organotypic brain slice cultures: effects of PLA2 inhibitor mepacrine and docosahexaenoic acid (DHA). | Brown J et al. | โ | 2009 | โ |
| Chronic alcohol consumption from adolescence-to-adulthood in mice--effect on growth and social behavior. | Zou H et al. | โ | 2009 | โ |
| Effects of different concentrations of sugarcane alcohol on food intake and nutritional status of male and female periadolescent rats. | Gonรงalves de Orange L et al. | โ | 2009 | โ |
| Functional brain imaging of development-related risk and vulnerability for substance use in adolescents. | Hardin MG et al. | โ | 2009 | โ |
| Heavy drinking is associated with deficient response inhibition in women but not in men. | Nederkoorn C et al. | โ | 2009 | โ |
| Impact of age at first drink on vulnerability to alcohol-related problems: testing the marker hypothesis in a prospective study of young adults. | Buchmann AF et al. | โ | 2009 | โ |
| Impulsivity, frontal lobes and risk for addiction. | Crews FT et al. | โ | 2009 | โ |
| Increased apoptosis and reduced neuronal and glial densities in the hippocampus due to nicotine and ethanol exposure in adolescent mice. | Oliveira-da-Silva A et al. | โ | 2009 | โ |
| Intra-cornu ammonis 1 administration of the human immunodeficiency virus-1 protein trans-activator of transcription exacerbates the ethanol withdrawal syndrome in rodents and activates N-methyl-D-aspartate glutamate receptors to produce persisting spatial learning deficits. | Self RL et al. | โ | 2009 | โ |
| Linking binge alcohol-induced neurodamage to brain edema and potential aquaporin-4 upregulation: evidence in rat organotypic brain slice cultures and in vivo. | Sripathirathan K et al. | โ | 2009 | โ |
| Long-term risk preference and suboptimal decision making following adolescent alcohol use. | Nasrallah NA et al. | โ | 2009 | โ |
| Mechanisms of neurodegeneration and regeneration in alcoholism. | Crews FT et al. | โ | 2009 | โ |
| Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats. | Gilpin NW et al. | โ | 2009 | โ |
| Post-training ethanol disrupts trace conditioned fear in rats: effects of timing of ethanol, dose and trace interval duration. | Hunt PS et al. | โ | 2009 | โ |
| Preventing and reducing underage drinking. | Galson SK | โ | 2009 | โ |
| Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult rats. | Wills TA et al. | โ | 2009 | โ |
| The heritability of P300 amplitude in 18-year-olds is robust to adolescent alcohol use. | Perlman G et al. | โ | 2009 | โ |
| The influence of chronic nicotine administration on behavioural and neurochemical parameters in male and female rats after repeated binge drinking exposure. | Lallemand F et al. | โ | 2009 | โ |
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| Acute ethanol effects on local cerebral glucose utilization in select central nervous system regions of adolescent alcohol-preferring (P) and alcohol-nonpreferring (NP) rats. | Strother WN et al. | โ | 2008 | โ |
| A developmental perspective on alcohol and youths 16 to 20 years of age. | Brown SA et al. | โ | 2008 | โ |
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| Alcohol-related neurodegeneration and recovery: mechanisms from animal models. | Crews FT | โ | 2008 | โ |
| A meta-analysis of marijuana and alcohol use by socio-economic status in adolescents aged 10-15 years. | Lemstra M et al. | โ | 2008 | โ |
| Behavioral responses during the initial exposures to a low dose of cocaine in late preweanling and adult rats. | Smith KS et al. | โ | 2008 | โ |
| Differential dietary ethanol intake and blood ethanol levels in adolescent and adult rats: effects on anxiety-like behavior and seizure thresholds. | Wills TA et al. | โ | 2008 | โ |
| Distinct cell proliferation events during abstinence after alcohol dependence: microglia proliferation precedes neurogenesis. | Nixon K et al. | โ | 2008 | โ |
| Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. | Ji D et al. | โ | 2008 | โ |
| Electrophysiological effects of dizocilpine (MK-801) in adult rats exposed to ethanol during adolescence. | Criado JR et al. | โ | 2008 | โ |
| Interactions between implicit and explicit cognition and working memory capacity in the prediction of alcohol use in at-risk adolescents. | Thush C et al. | โ | 2008 | โ |
| Intermittent binge alcohol exposure during the periadolescent period induces spatial working memory deficits in young adult rats. | Schulteis G et al. | โ | 2008 | โ |
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| Prefrontal cortex volumes in adolescents with alcohol use disorders: unique gender effects. | Medina KL et al. | โ | 2008 | โ |
| Review. Cognitive and emotional consequences of binge drinking: role of amygdala and prefrontal cortex. | Stephens DN et al. | โ | 2008 | โ |
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| Age of first marijuana use and the occurrence of marijuana use disorders in Southwest California Indians. | Ehlers CL et al. | โ | 2007 | โ |
| An inverse relationship between typical alcohol consumption and facial symmetry detection ability in young women. | Oinonen KA et al. | โ | 2007 | โ |
| A randomized clinical trial of a targeted intervention to moderate alcohol use and alcohol-related problems in at-risk adolescents. | Thush C et al. | โ | 2007 | โ |
| Chronic ethanol exposure during adolescence increases basal dopamine in the nucleus accumbens septi during adulthood. | Badanich KA et al. | โ | 2007 | โ |
| Chronic tolerance to the social consequences of ethanol in adolescent and adult Sprague-Dawley rats. | Varlinskaya EI et al. | โ | 2007 | โ |
| Decision making and binge drinking: a longitudinal study. | Goudriaan AE et al. | โ | 2007 | โ |
| Differential expression of ethanol-induced hypothermia in adolescent and adult rats induced by pretest familiarization to the handling/injection procedure. | Ristuccia RC et al. | โ | 2007 | โ |
| Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal volume and asymmetry. | Medina KL et al. | โ | 2007 | โ |
| Explicit and implicit alcohol-related cognitions and the prediction of future drinking in adolescents. | Thush C et al. | โ | 2007 | โ |
| HPA function in adolescence: role of sex hormones in its regulation and the enduring consequences of exposure to stressors. | McCormick CM et al. | โ | 2007 | โ |
| Influence of age at drinking onset on the alcohol deprivation effect and stress-induced drinking in female rats. | Fรผllgrabe MW et al. | โ | 2007 | โ |
| Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats. | Pascual M et al. | โ | 2007 | โ |
| P3 components and adolescent binge drinking in Southwest California Indians. | Ehlers CL et al. | โ | 2007 | โ |
| A 'best practices' approach to neuropathologic assessment in developmental neurotoxicity testing--for today. | Bolon B et al. | โ | 2006 | โ |
| Age at first intoxication and alcohol use disorders in Southwest California Indians. | Ehlers CL et al. | โ | 2006 | โ |
| A low chronic ethanol exposure induces morphological changes in the adolescent rat brain that are not fully recovered even after a long abstinence: an immunohistochemical study. | Evrard SG et al. | โ | 2006 | โ |
| Periadolescent exposure to ethanol and diazepam alters the aversive properties of ethanol in adult mice. | Graham DL et al. | โ | 2006 | โ |
| Possible role of nerve growth factor in the pathogenesis of alcohol dependence. | Yoon SJ et al. | โ | 2006 | โ |
| Repeated ethanol treatment in adolescent rats alters cortical NMDA receptor. | Sircar R et al. | โ | 2006 | โ |
| Structural and functional modifications in glutamateric synapses following prolonged ethanol exposure. | Chandler LJ et al. | โ | 2006 | โ |
| Two-choice reaction time performance in Sprague-Dawley rats exposed to alcohol during adolescence or adulthood. | Slawecki CJ | โ | 2006 | โ |
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| Binge drinking, cognitive performance and mood in a population of young social drinkers. | Townshend JM et al. | โ | 2005 | โ |
| CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction. | Pandey SC et al. | โ | 2005 | โ |
| Enhanced prepulse inhibition following adolescent ethanol exposure in Sprague-Dawley rats. | Slawecki CJ et al. | โ | 2005 | โ |
| Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and their combination: long-term behavioral, neurochemical and neuropharmacological effects in the rat. | Cassel JC et al. | โ | 2005 | โ |
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| Effects of heavy drinking, binge drinking, and family history of alcoholism on regional brain metabolites. | Meyerhoff DJ et al. | โ | 2004 | โ |
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| Long-lasting alterations of the mesolimbic dopamine system after periadolescent ethanol drinking by alcohol-preferring rats. | Sahr AE et al. | โ | 2004 | โ |
| Multiple binge alcohol consumption during rat adolescence increases anxiety but does not impair retention in the passive avoidance task. | Popoviฤ M et al. | โ | 2004 | โ |
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| The effects of alcohol on physiological processes and biological development. | โ | โ | 2004 | โ |
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| Animal models of periadolescent substance abuse. | Smith RF | โ | 2003 | โ |
| Binge ethanol treatment causes greater brain damage in alcohol-preferring P rats than in alcohol-nonpreferring NP rats. | Crews FT et al. | โ | 2003 | โ |
| Neural stem cells and alcohol. | Crews FT et al. | โ | 2003 | โ |
| Place conditioning: age-related changes in the rewarding and aversive effects of alcohol. | Philpot RM et al. | โ | 2003 | โ |
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| Binge ethanol exposure in adult rats causes necrotic cell death. | Obernier JA et al. | โ | 2002 | โ |
| Effects of adolescent ethanol exposure on ethanol consumption in adult rats. | Slawecki CJ et al. | โ | 2002 | โ |
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