Impulsivity, frontal lobes and risk for addiction.
- Authors
- Crews, Fulton Timm; Boettiger, Charlotte Ann
- Year
- 2009
- Journal
- Pharmacology, biochemistry, and behavior
- PMID
- 19410598
- DOI
- 10.1016/j.pbb.2009.04.018
- PMCID
- PMC2730661
Alcohol and substance abuse disorders involve continued use of substances despite negative consequences, i.e. loss of behavioral control of drug use. The frontal-cortical areas of the brain oversee behavioral control through executive functions. Executive functions include abstract thinking, motivation, planning, attention to tasks and inhibition of impulsive responses. Impulsiveness generally refers to premature, unduly risky, poorly conceived actions. Dysfunctional impulsivity includes deficits in attention, lack of reflection and/or insensitivity to consequences, all of which occur in addiction [Evenden JL. Varieties of impulsivity. Psychopharmacology (Berl) 1999;146:348-361.; de Wit H. Impulsivity as a determinant and consequence of drug use: a review of underlying processes. Addict Biol 2009;14:22-31]. Binge drinking models indicate chronic alcohol damages in the corticolimbic brain regions [Crews FT, Braun CJ, Hoplight B, Switzer III RC, Knapp DJ. Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats. Alcohol Clin Exp Res 2000;24:1712-1723] causing reversal learning deficits indicative of loss of executive function [Obernier JA, White AM, Swartzwelder HS, Crews FT. Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats. Pharmacol Biochem Behav 2002b;72:521-532]. Genetics and adolescent age are risk factors for alcoholism that coincide with sensitivity to alcohol-induced neurotoxicity. Cortical degeneration from alcohol abuse may increase impulsivity contributing to the development, persistence and severity of alcohol use disorders. Interestingly, abstinence results in bursts of neurogenesis and brain regrowth [Crews FT, Nixon K. Mechanisms of neurodegeneration and regeneration in alcoholism. Alcohol Alcohol 2009;44:115-127]. Treatments for alcoholism, including naltrexone pharmacotherapy and psychotherapy may work through improving executive functions. This review will examine the relationships between impulsivity and executive function behaviors to changes in cortical structure during alcohol dependence and recovery.
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| Effects of premature birth on the risk for alcoholism appear to be greater in males than females. | Manzardo AM et al. | β | 2011 | β |
| Evidence that 'food addiction' is a valid phenotype of obesity. | Davis C et al. | β | 2011 | β |
| Frontally mediated inhibitory processing and white matter microstructure: age and alcoholism effects. | Colrain IM et al. | β | 2011 | β |
| Genetic dissection of behavioral flexibility: reversal learning in mice. | Laughlin RE et al. | β | 2011 | β |
| Individual differences in local gray and white matter volumes reflect differences in temperament and character: a voxel-based morphometry study in healthy young females. | Van Schuerbeek P et al. | β | 2011 | β |
| Methamphetamine-induced locomotor changes are dependent on age, dose and genotype. | Good RL et al. | β | 2011 | β |
| Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain. | Alfonso-Loeches S et al. | β | 2011 | β |
| N4 component responses to pre-pulse startle stimuli in young adults: relationship to alcohol dependence. | Ehlers CL et al. | β | 2011 | β |
| Periadolescent ethanol exposure reduces adult forebrain ChAT+IR neurons: correlation with behavioral pathology. | Ehlers CL et al. | β | 2011 | β |
| Reduced cortical gray matter volume in male adolescents with substance and conduct problems. | Dalwani M et al. | β | 2011 | β |
| Reduced dorsal prefrontal gray matter after chronic ketamine use. | Liao Y et al. | β | 2011 | β |
| Repeated co-administrations of alcohol- and methamphetamine-produced anxiogenic effect could be associated with the neurotoxicity in the dentate gyrus. | Chuang JY et al. | β | 2011 | β |
| Repeated exposure to moderate doses of ethanol augments hippocampal glutamate neurotransmission by increasing release. | Chefer V et al. | β | 2011 | β |
| Stress and alcohol cues exert conjoint effects on go and stop signal responding in male problem drinkers. | Zack M et al. | β | 2011 | β |
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| Adolescence as a critical window for developing an alcohol use disorder: current findings in neuroscience. | Nixon K et al. | β | 2010 | β |
| A method for mapping intralocus interactions influencing excessive alcohol drinking. | Phillips TJ et al. | β | 2010 | β |
| A new test to measure attentional bias and cognitive disinhibition in drinkers, based on the Hayling task. | Rose AK et al. | β | 2010 | β |
| Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction. | Olive MF | β | 2010 | β |
| Cortical perfusion in alcohol-dependent individuals during short-term abstinence: relationships to resumption of hazardous drinking after treatment. | Durazzo TC et al. | β | 2010 | β |
| Delay discounting behavior and white matter microstructure abnormalities in youth with a family history of alcoholism. | Herting MM et al. | β | 2010 | β |
| EEG alpha phenotypes: linkage analyses and relation to alcohol dependence in an American Indian community study. | Ehlers CL et al. | β | 2010 | β |
| Effects of repeated withdrawal from alcohol on recovery of cognitive impairment under abstinence and rate of relapse. | Loeber S et al. | β | 2010 | β |
| Glutamatergic targets for enhancing extinction learning in drug addiction. | Cleva RM et al. | β | 2010 | β |
| Heterogeneity of reward mechanisms. | Lajtha A et al. | β | 2010 | β |
| Impulsivity, impulsive and reflective processes and the development of alcohol use and misuse in adolescents and young adults. | Wiers RW et al. | β | 2010 | β |
| Metabolite levels in the brain reward pathway discriminate those who remain abstinent from those who resume hazardous alcohol consumption after treatment for alcohol dependence. | Durazzo TC et al. | β | 2010 | β |
| Protein kinase C isozymes as regulators of sensitivity to and self-administration of drugs of abuse-studies with genetically modified mice. | Olive MF et al. | β | 2010 | β |
| Recruitment of additional brain regions to accomplish simple motor tasks in chronic alcohol-dependent patients. | Parks MH et al. | β | 2010 | β |
| Special issue in honor of professor Armen Galoyan. Preface. | Lajtha A | β | 2010 | β |
| The Effects of Naltrexone Among Alcohol Non-Abstainers: Results from the COMBINE Study. | Ray LA et al. | β | 2010 | β |
| The emergence of gonadal hormone influences on dopaminergic function during puberty. | Kuhn C et al. | β | 2010 | β |