Alcohol-related risk of suicidal ideation, suicide attempt, and completed suicide: a meta-analysis.
paper
Cited
Public
- Authors
- Darvishi, Nahid; Farhadi, Mehran; Haghtalab, Tahereh; Poorolajal, Jalal
- Year
- 2015
- Journal
- PloS one
- PMID
- 25993344
- DOI
- 10.1371/journal.pone.0126870
- PMCID
- PMC4439031
BACKGROUND: Several original studies have investigated the effect of alcohol use disorder (AUD) on suicidal thought and behavior, but there are serious discrepancies across the studies. Thus, a systematic assessment of the association between AUD and suicide is required. METHODS: We searched PubMed, Web of Science, and Scopus until February 2015. We also searched the Psycinfo web site and journals and contacted authors. We included observational (cohort, case-control, and cross-sectional) studies addressing the association between AUD and suicide. The exposure of interest was AUD. The primary outcomes were suicidal ideation, suicide attempt, and completed suicide. We assessed heterogeneity using Q-test and I2 statistic. We explored publication bias using the Egger's and Begg's tests and funnel plot. We meta-analyzed the data with the random-effects models. For each outcome we calculated the overall odds ratio (OR) or risk ratio (RR) with 95% confidence intervals (CI). RESULTS: We included 31 out of 8548 retrieved studies, with 420,732 participants. There was a significant association between AUD and suicidal ideation (OR=1.86; 95% CI: 1.38, 2.35), suicide attempt (OR=3.13; 95% CI: 2.45, 3.81); and completed suicide (OR=2.59; 95% CI: 1.95, 3.23 and RR=1.74; 95% CI: 1.26, 2.21). There was a significant heterogeneity among the studies, but little concern to the presence of publication bias. CONCLUSIONS: There is sufficient evidence that AUD significantly increases the risk of suicidal ideation, suicide attempt, and completed suicide. Therefore, AUD can be considered an important predictor of suicide and a great source of premature death.
Flow of information through the different phases of the systematic review.
Forest plot of the association between alcohol use disorder and suicide ideation.
Forest plot of the association between alcohol use disorder and suicide attempt.
Forest plot of the association between alcohol use disorder and completed suicide.
Funnel plot of included studies assessing the publication bias in studies addressing the association between alcohol use disorder and suicide ideation.
Funnel plot of included studies assessing the publication bias in studies addressing the association between alcohol use disorder and suicide attempt.
Funnel plot of included studies assessing the publication bias in studies addressing the association between alcohol use disorder and completed suicide.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Reciprocal relationships between substance use and disorders and suicidal ideation and suicide attempts in the Collaborative Study of the Genetics of Alcoholism. | 2017 | 28213124 |
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