Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
paper
Cited
Public
Unavailable
- Authors
- Takahashi, Kazutoshi; Yamanaka, Shinya
- Year
- 2006
- Journal
- Cell
- PMID
- 16904174
- DOI
- 10.1016/j.cell.2006.07.024
Differentiated cells can be reprogrammed to an embryonic-like state by transfer of nuclear contents into oocytes or by fusion with embryonic stem (ES) cells. Little is known about factors that induce this reprogramming. Here, we demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions. Unexpectedly, Nanog was dispensable. These cells, which we designated iPS (induced pluripotent stem) cells, exhibit the morphology and growth properties of ES cells and express ES cell marker genes. Subcutaneous transplantation of iPS cells into nude mice resulted in tumors containing a variety of tissues from all three germ layers. Following injection into blastocysts, iPS cells contributed to mouse embryonic development. These data demonstrate that pluripotent stem cells can be directly generated from fibroblast cultures by the addition of only a few defined factors.
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| A Guided Approach to Establish a Functional Humanized Brain-on-a-Chip Microfluidic Model of the Neurovascular System. | Raut S et al. | β | 2025 | β |
| A high-performance extracellular field potential analyzer for iPSC-derived cardiomyocytes. | Patel N et al. | β | 2025 | β |
| A history of omics discoveries reveals the correlates and mechanisms of loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young investigator award invited review. | Chambers TL et al. | β | 2025 | β |
| Airway epithelial stem cell renewal and differentiation: overcoming challenging steps towards clinical-grade tissue engineering. | Adamo D et al. | β | 2025 | β |
| AKT1 as a therapeutic target for platinum-resistant SOX2 positive ovarian cancer cells. | Xue M et al. | β | 2025 | β |
| A Landscape of Cancer Initiation and Cancer Stem Cells. | Seno M | β | 2025 | β |
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| Analysis of miRNAs from Inner Ear Organoid-Derived Extracellular Vesicles. | Lee S et al. | β | 2025 | β |
| Analysis of neuronal activity impairment in iPSC-derived neurons from idiopathic autism patients. | Kern A et al. | β | 2025 | β |
| A narrative review of the distribution and role of multipotent fibroblasts in penile tissue: implications for regenerative medicine and erectile dysfunction. | Fridayana FR et al. | β | 2025 | β |
| An axolotl limb regeneration-inspired strategy to enhance alveolar bone regeneration. | Liu R et al. | β | 2025 | β |
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| An Optimized Method to Produce Human-Induced Pluripotent Stem Cell-Derived Limbal Stem Cells Easily Adaptable for Clinical Use. | Edel MJ et al. | β | 2025 | β |
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| Anti-senescence therapies: a new concept to address cardiovascular disease. | StojanoviΔ SD et al. | β | 2025 | β |
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| A Personal Scientific Journey-Looking Back at My Journey in Science: How DNA Damage and Repair Led to the Role of Gap Junctional Intercellular Communication, Mechanisms of Tumor Promotion, Human Adult Stem Cells, "Cancer Stem Cells", Two Types of "Cancer Stem Cells" and the Modulation of Human Diseases by Epigenetic Toxins/Toxicants, Nutrition and Diets. | Trosko JE | β | 2025 | β |
| A pluripotent stem cell model of Emberger syndrome reveals reduced lymphatic endothelial differentiation. | Kouzuki K et al. | β | 2025 | β |
| A Polyomavirus-Positive Merkel Cell Carcinoma Mouse Model Supports a Unified Origin for Somatic and Germ Cell Cancers. | Yang W et al. | β | 2025 | β |
| Apoptotic priming in senescence predicts specific senolysis by quantitative analysis of mitochondrial dependencies. | MacDonald JA et al. | β | 2025 | β |
| Application of Biomaterials in Diabetic Wound Healing: The Recent Advances and Pathological Aspects. | Han C et al. | β | 2025 | β |
| Application of Endogenous Stem Cells in the Repair of Annulus Fibrosus Injury of Intervertebral Discs. | Zhao W et al. | β | 2025 | β |
| Application of induced pluripotent stem cells in the conservation of endangered animals. | Lou J et al. | β | 2025 | β |
| Application of neural stem cells in the treatment of intracerebral hemorrhage: a systematic review. | Song P et al. | β | 2025 | β |
| Application of scRNA-seq in Dental Research: Seeking Regenerative Clues From the Structure of Tooth and Periodontium in Physical or Pathological States. | Miao X et al. | β | 2025 | β |
| Application potential of induced pluripotent stem cells in the research and treatment of autoimmune diseases (Review). | Ye Z et al. | β | 2025 | β |
| A primer on global molecular responses to exercise in skeletal muscle: Omics in focus. | Murach KA et al. | β | 2025 | β |
| A protocol for karyotyping and genetic editing of induced pluripotent stem cells with homology-directed repair mediated CRISPR/Cas9. | Lobo S et al. | β | 2025 | β |
| A rapid chemical reprogramming system to generate human pluripotent stem cells. | Wang Y et al. | β | 2025 | β |
| Arginine methylation in cancer: mechanisms and therapeutic implications. | Xu Y et al. | β | 2025 | β |
| A role for NFIB in <i>SOX2</i> downregulation and epigenome accessibility changes due to long-term estrogen treatment of breast cancer epithelial cells. | Abatti L et al. | β | 2025 | β |
| ARSACS: Clinical Features, Pathophysiology and iPS-Derived Models. | Salem IH et al. | β | 2025 | β |
| Artificial Gametogenesis and In Vitro Spermatogenesis: Emerging Strategies for the Treatment of Male Infertility. | Kaltsas A et al. | β | 2025 | β |
| Artificial Nanovesicles Derived from Cells: A Promising Alternative to Extracellular Vesicles. | Lou S et al. | β | 2025 | β |
| A scalable platform for EPSC-Induced MSC extracellular vesicles with therapeutic potential. | Gong S et al. | β | 2025 | β |
| A scoping review of stem cell models of leukodystrophies: advances in understanding pathophysiological mechanisms. | Chapleau A et al. | β | 2025 | β |
| A simple, efficient technique to make colon crypt gels for 3D models. | Bieberich MA et al. | β | 2025 | β |
| Assessing <i>in-vitro</i> models for microglial development and fetal programming: a critical review. | Schepanski S et al. | β | 2025 | β |
| Asthma and stem cell therapy. | Chen QH et al. | β | 2025 | β |
| A systems view of cellular heterogeneity: Unlocking the "wheel of fate". | Movasat H et al. | β | 2025 | β |
| Autologous iPSC- and MSC-derived chondrocyte implants for cartilage repair in a miniature pig model. | Lee MS et al. | β | 2025 | β |
| Autophagy- and oxidative stress-related protein deregulation mediated by extracellular vesicles of human MJD/SCA3 iPSC-derived neuroepithelial stem cells and differentiated neural cultures. | MendonΓ§a LS et al. | β | 2025 | β |
| A versatile inΒ vivo platform for reversible control of transgene expression in adult tissues. | Taguchi J et al. | β | 2025 | β |
| Benzo[a]pyrene reduces cellular senescence in ovarian cancer by stabilizing c-Myc independently of DNA damage. | Fu Z et al. | β | 2025 | β |
| Beyond metaphor: quantitative reconstruction of Waddington landscape and exploration of cellular behavior. | Han Y et al. | β | 2025 | β |
| Bioengineering strategies for regeneration of skin integrity: A literature review. | Shiraishi M et al. | β | 2025 | β |
| Biomaterial platforms in cardiovascular regenerative medicine - challenges and future perspectives. | Vo QD | β | 2025 | β |
| Biomaterials and cell-based therapy post spinal cord injury. | Haratizadeh S et al. | β | 2025 | β |
| Biomaterials-driven stem cell therapy for tissue repair and functional rehabilitation after ischemic stroke. | Wang M et al. | β | 2025 | β |
| Biomimetic Approaches in the Development of Optimised 3D Culture Environments for Drug Discovery in Cardiac Disease. | Shepherd J | β | 2025 | β |
| Bioprinted Organoids: An Innovative Engine in Biomedicine. | Li Z et al. | β | 2025 | β |
| BMP4 cocktail promotes utricular progenitor reprogramming and vestibular functional recovery in adult mice. | You D et al. | β | 2025 | β |
| BMP and NODAL paracrine signalling regulate the totipotent-like cell state in embryonic stem cells. | Jagdish S et al. | β | 2025 | β |
| Body Fluid-Derived Stem Cells: Powering Innovative, Less-Invasive Cell Therapies. | Goff AD et al. | β | 2025 | β |
| Bone Tissue Engineering: From Biomaterials to Clinical Trials. | Jagadale S et al. | β | 2025 | β |
| Bottom-up Biomaterial strategies for creating tailored stem cells in regenerative medicine. | Cruz-Gonzalez B et al. | β | 2025 | β |
| Brain Organoids and Assembloids-From Disease Modeling to Drug Discovery. | Ajongbolo AO et al. | β | 2025 | β |
| Breaking Barriers in Huntington's Disease Therapy: Focused Ultrasound for Targeted Drug Delivery. | Helal MM et al. | β | 2025 | β |
| Bridging science, society and policy with the German Stem Cell Network. | Besser D et al. | β | 2025 | β |
| Bridging the gap: Canine in vitro models of the central nervous system as tools to study pathogenetic mechanisms in neurodegenerative disease and neuroinfectiology. | Beythien G et al. | β | 2025 | β |
| C3H10T1/2 Mesenchymal Stem Cell Line as a New In Vitro Tool for Studying Adipocyte Dedifferentiation. | Yuuki Y et al. | β | 2025 | β |
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| Can cell-cultured meat from stem cells pave the way for sustainable alternative protein? | Nunes OBDS et al. | β | 2025 | β |
| Cancer Reversion Therapy: Prospects, Progress and Future Directions. | Oisakede EO et al. | β | 2025 | β |
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| Canine organoids: state-of-the-art, translation potential for human medicine and plea for standardization. | Verduijn K et al. | β | 2025 | β |
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| Capturing avian somatic cells using feather pulp fibroblast culture as a non-invasive approach to biobanking endangered birds. | Blank MH et al. | β | 2025 | β |
| Cardiac organoids: a new tool for disease modeling and drug screening applications. | Yaqinuddin A et al. | β | 2025 | β |
| Cardiac repair and regeneration: cell therapy, in vivo reprogramming, and the promise of extracellular vesicles. | Karim Rony RMI et al. | β | 2025 | β |
| Cardiomyocyte sheet stacking using fibrin enables high-speed construction of three-dimensional myocardial tissue and high transplantation efficiency. | Sakaguchi K et al. | β | 2025 | β |
| Cartilage organoids: an emerging platform for novel osteoarthritis therapies. | Gao B et al. | β | 2025 | β |
| Cartilage organoids from basic research to clinical translation. | Zhang W et al. | β | 2025 | β |
| Categories, applications, and potential of stem cells in bone regeneration: an overview. | Jiao M et al. | β | 2025 | β |
| CD157<sup>+</sup> vascular endothelial cells derived from human-induced pluripotent stem cells have high angiogenic potential. | Takii A et al. | β | 2025 | β |
| Cell and tissue reprogramming: Unlocking a new era in medical drug discovery. | Sen CK et al. | β | 2025 | β |
| Cell-based artificial platelet production: historical milestones, emerging trends, and future directions. | Kim KM et al. | β | 2025 | β |
| Cell-based regenerative and rejuvenation strategies for treating neurodegenerative diseases. | Deng S et al. | β | 2025 | β |
| Cell-based treatments of lung diseases: overview and outlook. | van der Does AM et al. | β | 2025 | β |
| Cell culture research in aging and Alzheimer's disease: The strategic use/reuse of untreated controls and savings people's tax dollars. | Kshirsagar S et al. | β | 2025 | β |
| Cell reprogramming in cancer: Interplay of genetic, epigenetic mechanisms, and the tumor microenvironment in carcinogenesis and metastasis. | Shenoy S | β | 2025 | β |
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| Cell Reprogramming, Transdifferentiation, and Dedifferentiation Approaches for Heart Repair. | Almeida M et al. | β | 2025 | β |
| Cell therapy: A beacon of hope in the battle against pulmonary fibrosis. | Wan R et al. | β | 2025 | β |
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| Characterization of DNA methylation profile of the entire CpG island spanning the 5' untranslated region to intron 1 of the Oct4/POU5F1 gene in bovine gametes, embryos, and somatic cells. | Moura AO et al. | β | 2025 | β |
| Characterizing resistant cellular states in nasopharyngeal carcinoma during EBV lytic induction. | Wang X et al. | β | 2025 | β |
| CHD1L in cancer and beyond: structure, oncogenic functions, and therapeutic potential. | Clune S et al. | β | 2025 | β |
| Chemical-based epigenetic reprogramming to advance pluripotency and totipotency. | Wen S et al. | β | 2025 | β |
| Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespan. | Schoenfeldt L et al. | β | 2025 | β |
| Chemical reprogramming culture for the expansion of salivary gland epithelial basal progenitor cells. | Jeong YJ et al. | β | 2025 | β |
| Chemical reprogramming of human blood cells to pluripotent stem cells. | Peng F et al. | β | 2025 | β |
| Chemogenetic tuning reveals optimal MAPK signaling for cell-fate programming. | Lende-Dorn BA et al. | β | 2025 | β |
| Chitosan and hyaluronic acid in colorectal cancer therapy: A review on EMT regulation, metastasis, and overcoming drug resistance. | Han M et al. | β | 2025 | β |
| Cholangiocyte organoids for disease, cancer, and regenerative medicine. | Nagao M et al. | β | 2025 | β |
| Chondrocalcin: Insights into its regulation and multi-function in cartilage and bone. | Zhu W et al. | β | 2025 | β |
| Cis-regulatory Function of the Pou5f1 Gene Promoter in the Mouse MHC Locus. | Ermakova VV et al. | β | 2025 | β |
| Clinical Applications of Corneal Cells Derived from Induced Pluripotent Stem Cells. | Luan Y et al. | β | 2025 | β |
| Clinical perspective on pluripotent stem cells derived cell therapies for the treatment of neurodegenerative diseases. | Izrael M et al. | β | 2025 | β |
| Clinical state and future directions of stem cell therapy in stroke rehabilitation. | Habib P et al. | β | 2025 | β |
| Clinical translation of human iPSC technologies: advances, safety concerns, and future directions. | Dhaiban S et al. | β | 2025 | β |
| Coenzyme Q10 Ameliorates Chemotherapy-Induced Neurotoxicity in iPSC-Derived Neurons by Reducing Oxidative Stress. | Ababneh NA et al. | β | 2025 | β |
| Comparative analysis of mouse strains for in vivo induction of reprogramming factors. | PicΓ³ S et al. | β | 2025 | β |
| Complete genome assemblies of two mouse subspecies reveal structural diversity of telomeres and centromeres. | Francis BA et al. | β | 2025 | β |
| Compressive Forces Induce Epigenetic Activation of Aged Human Dermal Fibroblasts Through ERK Signaling Pathway. | Liu H et al. | β | 2025 | β |
| Connexin 43 suppression enhances contractile force in human iPSC-derived cardiac tissues. | Takada T et al. | β | 2025 | β |
| Considerations in biodistribution evaluation of iPSC-derived cell therapy: A pancreatic islet cell case study. | Nakayama M et al. | β | 2025 | β |
| Constructing a potential HLA haplo-homozygous induced pluripotent stem cell haplobank using data from an umbilical cord blood bank. | He J et al. | β | 2025 | β |
| Construction and Influence of Induced Pluripotent Stem Cells on Early Embryo Development in Black Bone Sheep. | Wang D et al. | β | 2025 | β |
| [Construction of cardiac organoids derived from human induced pluripotent stem cells for cardiac disease modeling and drug evaluation]. | Gong X et al. | β | 2025 | β |
| Construction of human pluripotent stem cell-derived testicular organoids and their use as humanized testis models for evaluating the effects of semaglutide. | Huang R et al. | β | 2025 | β |
| Controllability of the gene regulatory network in zebrafish embryogenesis. | Park J et al. | β | 2025 | β |
| Control of Gene Expression by Proteins That Bind Many Alternative Nucleic Acid Structures Through the Same Domain. | Herbert A | β | 2025 | β |
| Coupling of stemness maintenance with cell cycle control in stem cells. | Huang X et al. | β | 2025 | β |
| CRISPR antiviral inhibits neurotrophic JC polyomavirus in 2D and 3D culture models through dual-gRNA excision by SaCas9. | Rocchi A et al. | β | 2025 | β |
| CRISPR/Cas9 and iPSC-Based Therapeutic Approaches in Alzheimer's Disease. | Raffaele I et al. | β | 2025 | β |
| CRISPR/Cas-edited iPSCs and mesenchymal stem cells: a concise review of their potential in thalassemia therapy. | Shu J et al. | β | 2025 | β |
| Crosstalk between cancer stem cells and myeloid-derived suppressor cells: implications for tumor progression and immunotherapy. | Wang B et al. | β | 2025 | β |
| Cryopreservation practices in clinical and preclinical iPSC-based cell therapies: Current challenges and future directions. | Dobruskin M et al. | β | 2025 | β |
| Current advances and future prospects of cell reprogramming in progeroid syndromes. | Moledo-Nodar L et al. | β | 2025 | β |
| Current and emergent therapies targeting spinal cord injury. | Grasso G et al. | β | 2025 | β |
| Current Applications of Human Pluripotent Stem Cells in Neuroscience Research and Cell Transplantation Therapy for Neurological Disorders. | Verma I et al. | β | 2025 | β |
| Current approaches for Usher syndrome disease models and developing therapies. | Leith FK et al. | β | 2025 | β |
| Current Development of iPSC-Based Modeling in Neurodegenerative Diseases. | Guo X et al. | β | 2025 | β |
| Current opinion on pluripotent stem cell technology in Gaucher's disease: challenges and future prospects. | Gurra P et al. | β | 2025 | β |
| Current Position and Future Direction of Inflammation in Neuropsychiatric Disorders: A Review. | Upthegrove R et al. | β | 2025 | β |
| Current Progress of Tissue Engineering With Stem Cells in Urology Updated Review in 2025. | Kobayashi K et al. | β | 2025 | β |
| Decellularized Cell-Secreted Extracellular Matrices as Biomaterials for Tissue Engineering. | Ramos-Rodriguez DH et al. | β | 2025 | β |
| Deciphering alternative splicing patterns during cell fate transition of fast chemical reprogramming. | Lu Y et al. | β | 2025 | β |
| Deciphering reprogramming efficiency in human induced pluripotent stem cells: insights from the generation of 150 cell lines. | Kuebler B et al. | β | 2025 | β |
| Deciphering respiratory viral infections by harnessing organ-on-chip technology to explore the gut-lung axis. | Koceva H et al. | β | 2025 | β |
| Decoding cancer etiology with cellular reprogramming. | Huang MF et al. | β | 2025 | β |
| Decoding cell fate: integrated experimental and computational analysis at the single-cell level. | Zhou Y et al. | β | 2025 | β |
| Decoding human chemical reprogramming: mechanisms and principles. | Cheng L et al. | β | 2025 | β |
| Decoding Liver Fibrosis: How Omics Technologies and Innovative Modeling Can Guide Precision Medicine. | Codotto G et al. | β | 2025 | β |
| Defined culture conditions robustly maintain human stem cell pluripotency, highlighting a role for Ca<sup>2+</sup> signaling. | Eidhof I et al. | β | 2025 | β |
| Delayed Repolarization Caused by hERG Block With Different Drug Modalities Can Be Detected in Stem Cell-Derived Cardiomyocytes: Incubation Time Matters. | Qu Y et al. | β | 2025 | β |
| Derivation of Lung Organoids from Human-Induced Pluripotent Stem Cells for Respiratory Infection Studies. | Leibel SL | β | 2025 | β |
| Development of a Lentiviral Reporter System for In Vitro Reprogramming of Astrocytes to Neuronal Precursors. | Schnaubelt A et al. | β | 2025 | β |
| Development of a Manufacturing Process for ClinicalΒ Autologous hiPSC-Derived RetinalΒ PigmentΒ Epithelium. | Jha S et al. | β | 2025 | β |
| Development of an electroconductive Heart-on-a-chip model to investigate cellular and molecular response of human cardiac tissue to gold nanomaterials. | Esmaeili H et al. | β | 2025 | β |
| Developments and Applications of Liver-on-a-Chip Technology-Current Status and Future Prospects. | Mugaanyi J et al. | β | 2025 | β |
| Differentiation Defect Into GABAergic Neurons in Cerebral Organoids From Autism Patients. | Hali S et al. | β | 2025 | β |
| Differentiation of Human Pluripotent Cells into Pancreatic Beta Cells for Disease Modeling and Cell Replacement Therapy for Diabetes. | Barinova AA et al. | β | 2025 | β |
| Differentiation of Mature Dopaminergic Neurons from Human Induced Pluripotent Stem Cells. | Garg P et al. | β | 2025 | β |
| Differentiation of Mesenchymal Stromal/Stem Cells from Induced Pluripotent Stem Cells. | Marais AL et al. | β | 2025 | β |
| Differentiation properties of 3D scaffolds nanostructured with multi-walled carbon nanotubes on human induced pluripotent stem cells. | Cavion F et al. | β | 2025 | β |
| Dihydrotanshinone I enhanced BRAF mutant melanoma treatment efficacy by inhibiting the STAT3/SOX2 signaling pathway. | Luo X et al. | β | 2025 | β |
| Dimethyl Sulfoxide Conditions Induced Pluripotent Stem Cells for more Efficient Nephron Progenitor and Kidney Organoid Differentiation. | Kearney H et al. | β | 2025 | β |
| Direct fibroblast reprogramming: an emerging strategy for treating organic fibrosis. | Lin H et al. | β | 2025 | β |
| Direct in vivo reprogramming to relieve tissue ischemia via induced vasculogenesis. | Yoder MC et al. | β | 2025 | β |
| Direct Lineage Reprogramming of Fibroblasts into Functional Keratinocyte-Like Cells via BMI1 and FGFR2b for Diabetic Wound Repair. | Ma H et al. | β | 2025 | β |
| Direct reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells. | Morita A et al. | β | 2025 | β |
| Disease-modifying therapies for Alzheimer's disease: Clinical trial progress and opportunity. | Zhang Y et al. | β | 2025 | β |
| Disruption of Krox20-Notch1 signaling blocks meibomian gland development and homeostasis leading to dry eye disease. | Zhang Y et al. | β | 2025 | β |
| Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq. | Liu W et al. | β | 2025 | β |
| Distinct anticancer properties of exosomes from induced mesenchymal stem cells vs. bone marrow-derived stem cells in MCF7 and A549 models. | Ababneh NA et al. | β | 2025 | β |
| Distribution and metabolism of iPSC-MSCs in the joint cavity of an osteoarthritis rat model. | Yuan X et al. | β | 2025 | β |
| Divergent destinies: insights into the molecular mechanisms underlying EPI and PE fate determination. | Athanasouli P et al. | β | 2025 | β |
| Drug repurposing in amyotrophic lateral sclerosis (ALS). | Carroll E et al. | β | 2025 | β |
| DualNetM: an adaptive dual network framework for inferring functional-oriented markers. | Dai B et al. | β | 2025 | β |
| Dual prophylactic and therapeutic potential of iPSC-based vaccines and neoantigen discovery in colorectal cancer. | Jwo SH et al. | β | 2025 | β |
| Dual SMAD inhibitionΒ as a versatile platform in human pluripotent stem cell-based regenerative medicine and disease modeling. | Puspita L et al. | β | 2025 | β |
| Dynamic changes of intracellular signals in ATTR Tyr114Cys amyloidosis. | Ouchi K et al. | β | 2025 | β |
| Editorial: Induced pluripotent stem cells (iPSCs) for skeletal muscle diseases. | Sakurai H et al. | β | 2025 | β |
| Editorial: Methods in cellular neurobiology research. | Han S et al. | β | 2025 | β |
| Editorial: Role of induced pluripotent stem cells (iPSCs) in regenerative medicine, disease modeling and drug discovery. | O'Connor KC et al. | β | 2025 | β |
| Editorial: Senescence and reprogramming: hallmarks in aging and disease. | GonzΓ‘lez-Rico FJ et al. | β | 2025 | β |
| Effect of iPS cell culture medium on the differentiation potential of induced cardiac tissues. | Nakashima Y et al. | β | 2025 | β |
| Effect of Octacalcium Phosphate on Osteogenic Differentiation of Induced Pluripotent Stem Cells in a 3D Hybrid Spheroid Culture. | Sugai Y et al. | β | 2025 | β |
| Effects of embryonic origin, tissue cues and pathological signals on fibroblast diversity in humans. | Torregrossa M et al. | β | 2025 | β |
| Efficacy and safety assessment of homotopical transplantation of iPSCs-derived midbrain organoids into the substantia nigra of Parkinsonian rats. | Zheng X et al. | β | 2025 | β |
| Efficacy of Mesenchymal and Embryonic Stem Cell Therapy for the Treatment of Spinal Cord Injury: A Systematic Review and Meta-Analysis of Human Studies. | Troiani Z et al. | β | 2025 | β |
| Efficient and Reproducible Differentiation Protocol for Pluripotent Stem Cells into Functional Endothelial Cells: Unveiling the Path to Vascular Regeneration. | Azhdari M et al. | β | 2025 | β |
| Efficient differentiation of human iPSCs into Leydig-like cells capable of long-term stable secretion of testosterone. | Sato K et al. | β | 2025 | β |
| Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson's disease. | Ballion B et al. | β | 2025 | β |
| Embryoid bodies as a model system for exploring early human embryonic development. | Zhigalina DI et al. | β | 2025 | β |
| Embryonic stem cell-derived extracellular vesicles delay cellular senescence by inhibiting oxidative stress. | Enomoto S et al. | β | 2025 | β |
| Emerging brain organoids: 3D models to decipher, identify and revolutionize brain. | Zhao Y et al. | β | 2025 | β |
| Emerging concepts and novel mechanisms in organ fibrosis. | Ruiz-Villalba A et al. | β | 2025 | β |
| Endothelial Cell Phenotypic Plasticity in Cardiovascular Physiology and Disease: Mechanisms and Therapeutic Prospects. | de Queiroz DB et al. | β | 2025 | β |
| Engineered 3D immuno-glial-neurovascular human miBrain model. | Stanton AE et al. | β | 2025 | β |
| Engineered extracellular vesicles derived from pluripotent stem cells: a cell-free approach to regenerative medicine. | Wang AYL et al. | β | 2025 | β |
| Engineered iPSC-derived natural killer cells: recent innovations in translational innate anti-cancer immunotherapy. | Sun J et al. | β | 2025 | β |
| Engineered transcription factor-binding arrays for DNA-based gene expression control in mammalian cells. | Zouein A et al. | β | 2025 | β |
| Engineering a dynamic extracellular matrix using thrombospondin-1 to propel hepatocyte organoids reprogramming and improve mouse liver regeneration post-transplantation. | Xu ZY et al. | β | 2025 | β |
| Engineering aortic valves via transdifferentiating fibroblasts into valvular endothelial cells without using viruses or iPS cells. | Tang P et al. | β | 2025 | β |
| Engineering cardiology with miniature hearts. | Xia X et al. | β | 2025 | β |
| Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities. | Jeong HJ et al. | β | 2025 | β |
| Engineering the next generation of CAR T- cells: precision modifications, logic gates and universal strategies to overcome exhaustion and tumor resistance. | Garcia-Robledo JE et al. | β | 2025 | β |
| Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase. | Guo L et al. | β | 2025 | β |
| Enhanced differentiation capacity of parthenogenetic embryonic stem cells via incorporation of non-growing oocyte genomes in mouse. | Shao H et al. | β | 2025 | β |
| Epigenetic age predictors for non-invasive assessment of human skin. | Menendez Vazquez A et al. | β | 2025 | β |
| Epigenetic Regulation of Aging and its Rejuvenation. | An Y et al. | β | 2025 | β |
| Escaping ageing through Cell Annealing-a phenomenological model. | Memczak S et al. | β | 2025 | β |
| ESC Seed Cell Resource Bank. | Niu S et al. | β | 2025 | β |
| Essential and dual effects of Notch activity on a natural transdifferentiation event. | Daniele T et al. | β | 2025 | β |
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| Establishment and characterization of Cri Du Chat neuronal stem cells: a novel promising resource to study the syndrome. | Piovani G et al. | β | 2025 | β |
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| Expanding the cytokine receptor alphabet reprograms T cells into diverse states. | Zhao Y et al. | β | 2025 | β |
| Exploring hiPSC-CM replacement therapy in ischemic hearts. | Cipriano G et al. | β | 2025 | β |
| Exploring organoid and assembloid technologies: a focus on retina and brain. | Ouaidat S et al. | β | 2025 | β |
| Exploring the effects of gut microbiota on cholangiocarcinoma progression by patient-derived organoids. | Lederer AK et al. | β | 2025 | β |
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| FACS-Based Assessment of Human Hematopoietic Stem and Progenitor Cells. | Schmachtel T et al. | β | 2025 | β |
| Fat-derived neural stem cells promote nerve regeneration following peripheral nerve injury. | Ott LC et al. | β | 2025 | β |
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| Fibroblasts and hiPS-Derived Astrocytes From CoPAN Patients Showed Different Levels of Iron Overload Correlated With Senescent Phenotype. | Cozzi A et al. | β | 2025 | β |
| Fibroblasts-The emerging therapeutic target of the cardiovascular system? | Asselberghs SEJ et al. | β | 2025 | β |
| Flipons enable genomes to learn by intermediating the exchange of energy for information. | Herbert A | β | 2025 | β |
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| From induced pluripotent stem cell (iPSC) to universal immune cells: literature review of advances in a new generation of tumor therapies. | Zhang J et al. | β | 2025 | β |
| From in vivo models to in vitro bioengineered neuromuscular junctions for the study of Charcot-Marie-Tooth disease. | Scherrer C et al. | β | 2025 | β |
| From Molecules to Models: miRNAs and Advanced Human Platforms of Neurodegeneration and Repair in Multiple Sclerosis. | MuΓ±oz-San MartΓn M et al. | β | 2025 | β |
| From Organoids to Assembloids: Experimental Approaches to Study Human Neuropsychiatric Disorders. | Levy RJ et al. | β | 2025 | β |
| From the Masters: How RNA drugs will transform vascular medicine. | Cooke JP | β | 2025 | β |
| Frontier progress and translational challenges of pluripotent differentiation of stem cells. | Su Z et al. | β | 2025 | β |
| Functional Analysis of Antipsychotics in Human iPSC-Based Neural Progenitor 2D and 3D Schizophrenia Models. | Farkas KG et al. | β | 2025 | β |
| Functional analysis of human induced pluripotent stem cell-derived cardiac tissue during endothelial cell network changes. | Koike T et al. | β | 2025 | β |
| Functional and molecular single-cell analyses implicate PRDM14 in the initiation of B cell leukemia in mice. | Tracey LJ et al. | β | 2025 | β |
| Gene and Stem Cell-Based Therapies for Retinal Degenerative Diseases: Update, Challenges, and Future Directions. | Bhat MA et al. | β | 2025 | β |
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| Generation and assessment of high-quality fat-tailed dunnart oocytes following superovulation in prepubertal animalsβ . | Liu J et al. | β | 2025 | β |
| Generation and characterization of human-induced pluripotent stem cell lines from patients with autism spectrum disorder and SCN2A variants. | Santos JLS et al. | β | 2025 | β |
| Generation and Characterization of Human iPSC-Derived Astrocytes with Potential for Modeling X-Linked Adrenoleukodystrophy Phenotypes. | Kaur N et al. | β | 2025 | β |
| Generation and transcriptome profiling of bonobo induced pluripotent stem cells using stealth RNA vectors: a tripartite comparative study with humans and chimpanzees. | Hamazaki Y et al. | β | 2025 | β |
| Generation of 3D Human iPSC-Derived Multi-Cell Type Neurospheres for Studying Neuron, Astrocyte, and Microglia Crosstalk. | Wendt S et al. | β | 2025 | β |
| Generation of a Double Reporter mES Cell Line to Simultaneously Trace the Generation of Retinal Progenitors and Photoreceptors. | Zabiegalov O et al. | β | 2025 | β |
| Generation of chicken induced pluripotent stem cells (iPSCs) from somatic cells using multi-lentiviral transduction and OAC2. | Liu G et al. | β | 2025 | β |
| Generation of equine induced pluripotent stem cells from cells of embryonic, perinatal and adult tissues. | Barrachina L et al. | β | 2025 | β |
| Generation of human-induced pluripotent stem cells from a patient with Beckwith-Wiedemann syndrome. | Tang M et al. | β | 2025 | β |
| Generation of parathyroid glands from pluripotent stem cells. | Kano M | β | 2025 | β |
| Generation of the induced pluripotent stem cell line SJTUGHi004-A derived from a Best's disease patient with c.763CΒ >Β T mutation in BEST1 gene. | Jiang Y et al. | β | 2025 | β |
| Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients harbouring TTN mutations. | Tan R et al. | β | 2025 | β |
| Gene regulation technologies for gene and cell therapy. | Butterfield GL et al. | β | 2025 | β |
| Genes as Genome Stabilizers in Pluripotent Stem Cells. | Karmakar A et al. | β | 2025 | β |
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| Genomic and Epigenomic Analysis of Plasma Cell-Free DNA Identifies Stemness Features Associated with Worse Survival in Lethal Prostate Cancer. | Chauhan PS et al. | β | 2025 | β |
| Global morphogenesis regulating tissue architecture and organogenesis. | Ripamonti U | β | 2025 | β |
| Global research dynamics in the induced pluripotent stem cell and diabetes: A bibliometric analysis of the past twenty years. | Wang J et al. | β | 2025 | β |
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| Glycosylation in Stem Cell Biology. | Ogura C et al. | β | 2025 | β |
| Guanine nucleoside alleviates mycophenolic acid-induced toxicity in mouse embryonic stem cells. | Lin B et al. | β | 2025 | β |
| Gut Permeability and Microbiota in Parkinson's Disease: Mechanistic Insights and Experimental Therapeutic Strategies. | Liang Y et al. | β | 2025 | β |
| HAND2 invades nucleolar condensates to pioneer lineage-specific cardiac pacemaker gene programs. | Kulkarni K et al. | β | 2025 | β |
| Harnessing nanotechnology for stem-cell therapies: revolutionizing neurodegenerative disorder treatments - a state-of-the-art update. | Chengebroyen N et al. | β | 2025 | β |
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| Harnessing the ubiquitin proteasome system as a key player in stem cell biology. | Atta H et al. | β | 2025 | β |
| Heart-derived endogenous stem cells. | Inouye K et al. | β | 2025 | β |
| Heart Regeneration and Repair: Molecular Mechanism and Therapeutic Targets. | Liu M et al. | β | 2025 | β |
| Hematopoietic stem cells: Understanding the mechanisms to unleash the therapeutic potential of hematopoietic stem cell transplantation. | Aljagthmi AA et al. | β | 2025 | β |
| Heterogeneity of Cellular Senescence: Subtype-Specific Mechanisms and the Emerging Role of Plasma Membrane Damage. | Alghamdi E et al. | β | 2025 | β |
| Heterologous expression of bovine histone H1foo into porcine fibroblasts alters the transcriptome profile but not embryo development following nuclear transfer. | de Macedo MP et al. | β | 2025 | β |
| High Mobility Group A1 Chromatin Keys: Unlocking the Genome During MPN Progression. | Resar LMS et al. | β | 2025 | β |
| Hormesis and Muscle Plasticity. | Radak Z | β | 2025 | β |
| hPSC-based treatment of retinal diseases - Current progress and challenges. | Ozaki A et al. | β | 2025 | β |
| Human Blastoid: A Next-Generation Model for Reproductive Medicine? | Ryabchenko AS et al. | β | 2025 | β |
| Human brain organoids: an innovative model for neurological disorder research and therapy. | Li H et al. | β | 2025 | β |
| Human Cardiac Organoids: Advances and Prospects from Construction to Preclinical Drug Evaluation. | Chen M et al. | β | 2025 | β |
| Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury. | Vidman S et al. | β | 2025 | β |
| Human induced pluripotent stem cell models for Alzheimer's disease research: a bibliometric analysis. | Sun Y et al. | β | 2025 | β |
| Human-Induced Pluripotent Stem Cells (iPSCs) for Disease Modeling and Insulin Target Cell Regeneration in the Treatment of Insulin Resistance: A Review. | Thiab S et al. | β | 2025 | β |
| Human iPSC-Based in Vitro Cardiovascular Tissue Models for Drug Screening Applications. | Anand S et al. | β | 2025 | β |
| Human iPSC Reprogramming Success: The Impact of Approaches and Source Materials. | Pozner T et al. | β | 2025 | β |
| Human iPSCs-derived mesenchymal stem cells promote skin regeneration and burn wound healing. | Farahat M et al. | β | 2025 | β |
| Human kidney organoids for modeling the development of different diseases. | Ceccotti E et al. | β | 2025 | β |
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| Human Pluripotent Stem Cell-Based Therapies for Parkinson's Disease: Challenges and Potential Solutions. | Chang MY et al. | β | 2025 | β |
| Human PSC-derived liver cells and their applications for disease models and drug discovery. | Koui Y et al. | β | 2025 | β |
| Human stem cells with in vivo high plasticity generated by cell-cell communication. | Li S et al. | β | 2025 | β |
| Hydrogel-Based Biomaterials in Spinal Repair: Evaluating Mechanisms for IVDD, SCI, and Dural Regeneration. | Wang Y et al. | β | 2025 | β |
| Hydrogels for Cardiac Tissue Regeneration: Current and Future Developments. | Holme S et al. | β | 2025 | β |
| Hyperresponsiveness to inflammatory stimulation in human neuronal-like cells from patients with inflammation-associated depression. | Schillo SE et al. | β | 2025 | β |
| Hypoimmunogenic pluripotent stem cells: A game-changer in cell-based regenerative medicine. | Asadi-Sarabi P et al. | β | 2025 | β |
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| Hypoxia and Multilineage Communication in 3D Organoids for Human Disease Modeling. | Ehab S et al. | β | 2025 | β |
| Identification and function of periosteal skeletal stem cells in skeletal development, homeostasis, and disease. | Shi F et al. | β | 2025 | β |
| Identifying regulators of aged fibroblast activation in 3D tissue models. | Liu H et al. | β | 2025 | β |
| Illuminating the future of diabetes treatment: Autologous CiPSC-derived islets take center stage. | Lou Y | β | 2025 | β |
| <i>MAPT</i>-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis. | Itsuno M et al. | β | 2025 | β |
| Immortality Reconsidered: Clinical Challenges at the Frontier of Plastic Surgery. | Xun H et al. | β | 2025 | β |
| Impact of circadian rhythm on differentiation and maturation of insulin-producing cells. | Moon JE et al. | β | 2025 | β |
| Impact of differentiation protocols on the functionality of mesenchymal stem cells derived from induced pluripotent stem cells. | Ababneh NA et al. | β | 2025 | β |
| Incorporation of iPSCs together with TERT-immortalized keratinocytes and fibroblasts into reconstructed human gingiva enhances phenotype of gingival epithelium. | Brueske LL et al. | β | 2025 | β |
| Induced Mesenchymal Stem Cells: An Emerging Source for Regenerative Medicine Applications. | Choudhery MS et al. | β | 2025 | β |
| Induced Pluripotent (iPSC) and Mesenchymal (MSC) Stem Cells for In Vitro Disease Modeling and Regenerative Medicine. | Panferov E et al. | β | 2025 | β |
| Induced Pluripotent Stem Cell-Based Cancer Immunotherapy: Strategies and Perspectives. | Xun X et al. | β | 2025 | β |
| Induced Pluripotent Stem Cell-Derived Dendritic Cells Provide a Reliable In Vitro Platform for Functional Screening of Immunoregulatory Probiotics. | Chiang YL et al. | β | 2025 | β |
| Induced pluripotent stem cell-derived mesenchymal stem cells (iMSCs) inhibit M1 macrophage polarization and reduce alveolar bone loss associated with periodontitis. | Chen L et al. | β | 2025 | β |
| Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease. | Yi LX et al. | β | 2025 | β |
| Induced Pluripotent Stem Cells-Based Regenerative Therapies in Treating Human Aging-Related Functional Decline and Diseases. | Yu P et al. | β | 2025 | β |
| Induced Pluripotent Stem Cells for the Treatment of Lysosomal Storage Disorders. | Lorino M et al. | β | 2025 | β |
| Induced Pluripotent Stem Cells in Cardiomyopathy: Advancing Disease Modeling, Therapeutic Development, and Regenerative Therapy. | Vo QD et al. | β | 2025 | β |
| Induced Pluripotent Stem Cells in Congenital Long QT Syndrome: Research Progress and Clinical Applications. | Li Q et al. | β | 2025 | β |
| Induced Pluripotent Stem Cells (iPSC) and Their Use in Disease Modeling. | Dorota A et al. | β | 2025 | β |
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| Inhibition of mesenchymal drift as a strategy for rejuvenation. | de Lima Camillo LP | β | 2025 | β |
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| Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia. | Liu W et al. | β | 2025 | β |
| Innovations, Challenges, and Regulatory Pathways in Cultured Meat for a Sustainable Future. | Khan I et al. | β | 2025 | β |
| Innovative approaches to boost mesenchymal stem cells efficacy in myocardial infarction therapy. | An C et al. | β | 2025 | β |
| Innovative integration of biometric data and blockchain to enhance ownership and trust with NFTs. | Heo SE et al. | β | 2025 | β |
| Insights into Noncanonical and Diversified Functions of ABCF1: From Health to Disease. | Duan J et al. | β | 2025 | β |
| In silico modeling of directed differentiation of induced pluripotent stem cells to definitive endoderm. | Mostofinejad A et al. | β | 2025 | β |
| Integrating allostasis and emerging technologies to study complex diseases. | Park I et al. | β | 2025 | β |
| Integrative analyses of mendelian randomization and bioinformatics reveal casual relationship and genetic links between COVID-19 and knee osteoarthritis. | Zheng X et al. | β | 2025 | β |
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| Intraosseous adipose mesenchymal stem cells and plasma rich in growth factors: A promising approach for articular cartilage and subchondral bone regeneration. | Torres-Torrillas M et al. | β | 2025 | β |
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| Investigating the hepatic developmental toxicity of synthetic phenolic antioxidant 3-BHA: A comprehensive network-based approach combined with human embryonic stem cell-derived hepatocyte models. | Nijiati N et al. | β | 2025 | β |
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| In Vivo Reprogramming Highlights Epigenetic Regulation That Shapes Cancer Hallmarks. | Yamada Y et al. | β | 2025 | β |
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| Japan's big bet on stem-cell therapies might soon pay off with medical breakthroughs. | Mallapaty S | β | 2025 | β |
| KDM3A and KDM3B regulate alternative splicing in mouse pluripotent stem cells. | Dillingham CM et al. | β | 2025 | β |
| KLF4 in cancer chemoresistance: molecular mechanisms and therapeutic implications. | Yadav SS et al. | β | 2025 | β |
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| Large-Scale Production of Transfusion-Ready Red Blood Cells From Induced Pluripotent Stem Cells. | Varga E et al. | β | 2025 | β |
| Leigh Syndrome: A Comprehensive Review of the Disease and Present and Future Treatments. | Magro G et al. | β | 2025 | β |
| Leukemic Transdifferentiation: From Pathological Plasticity to Dendritic Cell-Based Immunotherapy. | Dubis J et al. | β | 2025 | β |
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| Liver regeneration: unraveling the molecular mechanisms and clinical application. | Wang N et al. | β | 2025 | β |
| Liver Transplantation in a Child With Homozygous Familial Hypercholesterolemia: A Case Report and Literature Review. | Zhong C et al. | β | 2025 | β |
| Locking the Fate: How PROX1 Represses Plasticity and Liver Cancer. | Lee SW et al. | β | 2025 | β |
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| Long-read RNA-sequencing reveals transcript-specific regulation in human-derived cortical neurons. | Xu J et al. | β | 2025 | β |
| Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs. | Kim DH et al. | β | 2025 | β |
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| Low-intensity pulsed ultrasound promotes proliferation and differentiation of neural stem cells to enhance spinal cord injury recovery. | Liao YH et al. | β | 2025 | β |
| <i>In vitro</i> derivation of megakaryocytes and platelets from induced pluripotent stem cells: developmental foundations and translational perspectives. | Mazurek M et al. | β | 2025 | β |
| <i>In vitro</i> models of muscle spindles: From traditional methods to 3D bioprinting strategies. | Kang Y et al. | β | 2025 | β |
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| Maturation of human induced pluripotent stem cell-derived cardiomyocytes promoted by Brachyury priming. | Kargaran PK et al. | β | 2025 | β |
| Measurements of neurite extension and nucleokinesis in an iPSC-derived model system following microtubule perturbation. | SΓ©bastien M et al. | β | 2025 | β |
| Mechanical function of scaffold-free cardiac tissue fabricated using a temperature-responsive culture dish depends on the degree of shrinkage and load. | Nishina S et al. | β | 2025 | β |
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| Metabolic Culture Medium Enhances Maturation of Human iPSC-Derived Cardiomyocytes via Cardiac Troponin I Isoform Induction. | Goliusova DV et al. | β | 2025 | β |
| Metabolic Maturation in hiPSC-Derived Cardiomyocytes: Emerging Strategies for Inducing the Adult Cardiac Phenotype. | Malan D et al. | β | 2025 | β |
| Metal Ion Signaling in Biomedicine. | Rodriguez R et al. | β | 2025 | β |
| Metformin and Dietary Restriction Counteract Aging via Reducing m6A-Dependent Stabilization of Methionine Synthase mRNA in Brachionus asplanchnoidis (Rotifera). | Zhang Y et al. | β | 2025 | β |
| Metformin Protects Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons from Oxidative Damage Through Antioxidant Mechanisms. | Gharandouq MH et al. | β | 2025 | β |
| Methods for Pluripotent Stem Cell Characterization: A Narrative Review. | Temsamani F et al. | β | 2025 | β |
| MFGE8 Acts as a Cell Adhesion Factor for Human-Induced Pluripotent Stem Cells in Embryology. | Nakashima Y et al. | β | 2025 | β |
| Microfluidic technologies for enhancing the potency, predictability and affordability of adoptive cell therapies. | Wang Z et al. | β | 2025 | β |
| Microglial involvement in autism spectrum disorder: insights from human data and iPSC models. | Michels S et al. | β | 2025 | β |
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| Microvascularization in 3D Human Engineered Tissue and Organoids. | Shin YJ et al. | β | 2025 | β |
| miRNAs from Zebrafish Embryo Extracts Inhibit Breast Cancer Invasiveness and Migration by Modulating miR-218-5p/PI3K Pathway. | Monti N et al. | β | 2025 | β |
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| The Rapid Activation of MYDGF Is Critical for Cell Survival in the Acute Phase of Retinal Regeneration in Fish. | Sugitani K et al. | β | 2025 | β |
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| Transplant of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Strips for Macular Degeneration and Retinitis Pigmentosa. | Sakai D et al. | β | 2025 | β |
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| Skin and Induced Pluripotent Stem Cells as Biomarkers for Neurodegenerative Diseases. | Rallis E et al. | β | 2024 | β |
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| The role of the SOX2 gene in cervical cancer: focus on ferroptosis and construction of a predictive model. | Liu S et al. | β | 2024 | β |
| Time-efficient strategies in human iPS cell-derived pancreatic progenitor differentiation and cryopreservation: advancing towards practical applications. | Genova E et al. | β | 2024 | β |
| Transplantation of derivative retinal organoids from chemically induced pluripotent stem cells restored visual function. | Zhao N et al. | β | 2024 | β |