Direct conversion of fibroblasts to functional neurons by defined factors.
paper
Cited
Public
- Authors
- Vierbuchen, Thomas; Ostermeier, Austin; Pang, Zhiping P; Kokubu, Yuko; Südhof, Thomas C; Wernig, Marius
- Year
- 2010
- Journal
- Nature
- PMID
- 20107439
- DOI
- 10.1038/nature08797
- PMCID
- PMC2829121
Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four transcription factors. This raised the question of whether transcription factors could directly induce other defined somatic cell fates, and not only an undifferentiated state. We hypothesized that combinatorial expression of neural-lineage-specific transcription factors could directly convert fibroblasts into neurons. Starting from a pool of nineteen candidate genes, we identified a combination of only three factors, Ascl1, Brn2 (also called Pou3f2) and Myt1l, that suffice to rapidly and efficiently convert mouse embryonic and postnatal fibroblasts into functional neurons in vitro. These induced neuronal (iN) cells express multiple neuron-specific proteins, generate action potentials and form functional synapses. Generation of iN cells from non-neural lineages could have important implications for studies of neural development, neurological disease modelling and regenerative medicine.
A screen for neuronal fate inducing factors and characterization of MEF-derived iN cellsa, Experimental rationale. b, Uninfected, p3 TauEGFP MEFs contained rare Tuj1-positive cells (red) with flat morphology. Blue: DAPI counterstain. c, Tuj1-positive fibroblasts do not express visible TauEGFP. d–e, MEF-iN cells express Tuj1 (red) and TauEGFP (green) and display complex neuronal morphologies 32 days after infection with the 19-factor (19F) pool. f, Tuj1 expression in MEFs 13 days after infection with the 5F pool. g–j, MEF-derived Tuj1-positive iN cells co-express the pan-neuronal markers TauEGFP (h), NeuN (red,i) and MAP2 (red,j). k, Representative traces of membrane potential responding to step depolarization by current injection (lower panel). Membrane potential was current-clamped at around −65 mV. l, Representative traces of whole-cell currents in voltage-clamp mode, cell was held at −70 mV, step depolarization from −90 mV to 60 mV at 10 mV interval were delivered (lower panel). Insert showing Na+currents. m, Spontaneous action potentials (AP) recorded from a 5F MEF-iN cell 8 days post infection. No current injection was applied. n–p, 22 days post-infection 5F MEF-iN cells expressed synapsin (red,n) and vesicular glutamate transporter 1 (vGLUT1) (red,o) or GABA (p). Scale bars = 5 μm (o), 10 μm (e,n,p) 20 μm (c,h,i), and 200 μm (f).
Efficient induction of neurons from perinatal tail-tip fibroblastsa, Tuj1-stained tail-tip fibroblast 13 days after infection 5F pool. b–c, TTF-iNs express the pan-neuronal markers MAP2 (b) and NeuN (c). d, Representative traces showing action potentials elicited at day 13 post infection. Nine of eleven cells recorded exhibited APs. e, Whole cell currents recorded in voltage-clamp mode. Inward fast inactivating sodium currents (arrow) and outward currents can be observed. f–h, 21 days after infection TTF-iN cells express synapsin (red, f), vGLUT1 (red g) and GABA (h). c, f, and g are overlay images with the indicated marker (red) and Tuj1 (green). Scale bars = 20 μm (b,f,g), 100 μm (h), 200 μm (a).
The 5F pool induced conversion is rapid and efficienta, Tuj1-positive iN cells (red) exhibit morphological maturation over time after viral infections. At day 13, TauEGFP expression outlines neuronal processes. b, FACS analysis of TauEGFP expression 8 and 13 days post infection. Control = Uninfected TauEGFP MEFs. c, Representative traces showing action potentials elicited from MEF-iN cells at days 8, 12, and 20 post infection. Cells were maintained at a potential of ~ −65 to −70mV. Step current injection protocols were used from −50 to +70 pA. Scale bars apply to all traces. d–g, Quantification of membrane properties in MEF-iN cells at 8, 12, and 20 days post infection. Numbers in the bars represent the numbers of recorded cells. Data are presented as mean±S.E.M. * p<0.05; **p<0.01; *** p<0.001 (Student’s t-test). AP: Action Potentials; RMP: Resting Membrane Potentials; Rin: Membrane input resistances; Cm: Membrane Capacitance. AP heights were measured from the baseline. h, BrdU-positive iN cells following BrdU treatment from day 0–13 or day 1–13 after transgene induction. i, Example of a Tuj1 (green) positive cell not labeled with BrdU (red) when added at day 0 after addition of doxycycline. Data are presented as mean ±S.D. j, Efficiency estimates for iN cell generation 13 days after infection (see methods). Every bar represents an independent experiment. Doxycycline was added to 48 hours after plating in MEF experiment #1 and after 24 hours in MEF experiments #2, #3. Error bars = ±1 S.D. of cell counts. Scale Bars = 10 μm (j), 100 μm (a).
MEF-derived iN cells exhibit functional synaptic propertiesTauEGFP-positive iN cells were FACS purified 7–8 days post infection of MEFs and plated on cortical neuronal cultures (7 days in vitro, a–f) or on monolayer glial cultures (g–i). Electrophysiological recordings were performed 7–10 days after sorting. a, Recording electrode (Rec.) patched onto an TauEGFP-positive cell (middle panel) with a stimulation electrode (Sti.). right panel, merged picture of DIC and fluorescence images showing the recorded cell is TauEGFP positive. b, Representative traces of spontaneous synaptic network activities and representative evoked postsynaptic currents (PSCs) following stimulation. c, In the presence of 20 μM CNQX and 50 μM D-APV, upper panel shows a representative trace of spontaneous IPSCs. Evoked IPSC could be elicited (middle panel) and blocked by the addition of picrotoxin. When a train of 10 stimulations was applied at 10 Hz, evoked IPSCs exhibit depression (lower panel). d, In the presence of 30 μM picrotoxin, excitatory synaptic activities from EGFP-positive cells were observed. Spontaneous-(upper panel), and evoked-(middle panel) EPSCs. At a holding potential of −70 mV, AMPA receptor (R) -mediated EPSCs were monitored. When holding potential were set at +60 mV, both AMPA R- and NMDA R-mediated EPSCs could be recorded. Lower panel shows the short-term synaptic plasticity of both AMPA R- and NMDA R- mediated synaptic activities. e, Example of a TauEGFP-positive iN cell expressing MAP2 among cortical neurons. f, High magnification of area marked with dotted lines in e. g, Representative spontaneous postsynaptic currents (PSCs) recorded from MEF-iN cells co-cultured with glia. h, Representative traces of evoked EPSCs. NMDA R-mediated EPSCs in the presence of 10 μM NBQX were recorded at holding potential (Vh) of +60 mV. Application of D-APV blocked the response. AMPA R-mediated EPSCs were recorded at Vh of −70 mV. AMPA R-evoked response is blocked by NBQX and APV. i, Current-voltage (I-V) relationship of NMDA R-mediated EPSCs, left panel; representative traces of evoked EPSCs at different Vh as indicated. Right panel shows the summarized I-V relationship. NMDA-R EPSC amplitudes (INMDA) are normalized to EPSCs at Vh of +60 mV (indicated by *, n=5). NMDA-R EPSCs show ratifications at negative holding potentials, presumably because of the blockade of NMDA-R by Mg2+. Scale bars = 10 μm (a,d).
Defining a minimal pool for efficient induction of functional iN cellsa, Quantification of Tuj1-positive iN cells from TauEGFP MEFs infected with different 3-factor combinations of the five genes. Each gene is represented by the first letter in its name. Averages from 30 randomly selected visual fields are shown (error bars= ± S.D.) b–d, Representative images of Tuj1 staining of MEFs infected with the 5F (b), Ascl1+Brn2+Zic1 (ABZ) (c) and Ascl1+Brn2+Myt1L (BAM) (d) pools. e, Tuj1 staining of perinatal TTF-iN cells 13 days after infection with the BAM pool. f, BAM-induced MEF-iN cells express MAP2 (green) and synapsin (red) 22 days after infection. g, Representative traces of synaptic responses recorded from MEF-derived BAM (3F)-iN cells co-cultured with glia after isolation by FACs. Vh: holding potential. At Vh of −70 mV, AMPA R-mediated EPSCs were recorded; at Vh of +60 mV, NMDA R-mediated EPSCs were revealed. h, Synaptic responses recorded from TTF-derived 3F-iN cells. Scale bars in (h) apply to traces in (g). i, Representative traces of action potentials elicited from MEF-derived iN cells transduced with the indicated gene combinations, recorded 12 days after infection. Cells were maintained at a resting membrane potential of ~−65 to −70mV. Step current injection protocols were used from −50 to +70 pA. Traces in each subgroup (left or right panels) represent subpopulations of neurons with similar responses. Numbers indicate the fraction of cells from each group that were qualitatively similar to the traces shown. Right panels: representative images of Tuj1 staining after recordings from each condition. Scale bars = 20 μm (f) and 100 μm (b,i).
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| Reprogramming astroglia into neurons with hallmarks of fast-spiking parvalbumin-positive interneurons by phospho-site-deficient Ascl1. | Marichal N et al. | — | 2024 | → |
| Reprogramming Stars #14: Fast-Forwarding Cellular Reprogramming- An Interview with Dr. Mark Kotter. | Kotter MR et al. | — | 2024 | → |
| RFX4 is an intrinsic factor for neuronal differentiation through induction of proneural genes POU3F2 and NEUROD1. | Choi W et al. | — | 2024 | → |
| Small molecules reprogram reactive astrocytes into neuronal cells in the injured adult spinal cord. | Tan Z et al. | — | 2024 | → |
| Strategies for modeling aging and age-related diseases. | Jothi D et al. | — | 2024 | → |
| Surface tension enables induced pluripotent stem cell culture in commercially available hardware during spaceflight. | Mozneb M et al. | — | 2024 | → |
| Synaptotagmins family affect glucose transport in retinal pigment epithelial cells through their ubiquitination-mediated degradation and glucose transporter-1 regulation. | Xu H et al. | — | 2024 | → |
| Systematic Evaluation of Extracellular Coating Matrix on the Differentiation of Human-Induced Pluripotent Stem Cells to Cortical Neurons. | Li S et al. | — | 2024 | → |
| The proneural factors Ascl1a and Ascl1b contribute to the terminal differentiation of dopaminergic GABAergic dual transmitter neurons in zebrafish. | Altbürger C et al. | — | 2024 | → |
| Transcriptional Factors Mediated Reprogramming to Pluripotency. | Fatima N et al. | — | 2024 | → |
| Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation. | Singh PNP et al. | — | 2024 | → |
| Transdifferentiation occurs without resetting development-specific DNA methylation, a key determinant of full-function cell identity. | Radwan A et al. | — | 2024 | → |
| 2p25.3 microduplications involving MYT1L: further phenotypic characterization through an assessment of 16 new cases and a literature review. | Bouassida M et al. | — | 2023 | → |
| A cutting-edge strategy for spinal cord injury treatment: resident cellular transdifferentiation. | Fang YM et al. | — | 2023 | → |
| A human stem cell-derived neuronal model of morphine exposure reflects brain dysregulation in opioid use disorder: Transcriptomic and epigenetic characterization of postmortem-derived iPSC neurons. | Mendez EF et al. | — | 2023 | → |
| Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons. | Popova D et al. | — | 2023 | → |
| Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells? | Rodriguez-Jimenez FJ et al. | — | 2023 | → |
| Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths. | Vainorius G et al. | — | 2023 | → |
| ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors. | Wang L et al. | — | 2023 | → |
| ASCL1-mediated ferroptosis resistance enhances the progress of castration-resistant prostate cancer to neurosecretory prostate cancer. | Nie J et al. | — | 2023 | → |
| Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons. | Pietiläinen O et al. | — | 2023 | → |
| A variegated model of transcription factor function in the immune system. | Chowdhary K et al. | — | 2023 | → |
| Cdk5 activation promotes Cos-7 cells transition towards neuronal-like cells. | Bao L et al. | — | 2023 | → |
| Cell Transdifferentiation: A Challenging Strategy with Great Potential. | Wang F et al. | — | 2023 | → |
| Cellular reprogramming of fibroblasts in heart regeneration. | Chi C et al. | — | 2023 | → |
| Characterization by Gene Expression Analysis of Two Groups of Dopaminergic Cells Isolated from the Mouse Olfactory Bulb. | Casciano F et al. | — | 2023 | → |
| Charting a high-resolution roadmap for regeneration of pancreatic β cells by in vivo transdifferentiation from adult acinar cells. | Liu G et al. | — | 2023 | → |
| Chemical Transdifferentiation of Somatic Cells: Unleashing the Power of Small Molecules. | Zhang Y et al. | — | 2023 | → |
| Chromodomain helicase DNA binding protein 4 in cell fate decisions. | Laureano A et al. | — | 2023 | → |
| COMMD10 Is Essential for Neural Plate Development during Embryogenesis. | Phan KP et al. | — | 2023 | → |
| Complex Autism Spectrum Disorder in a Patient with a Novel De Novo Heterozygous <i>MYT1L</i> Variant. | Yip S et al. | — | 2023 | → |
| Conserved transcription factors promote cell fate stability and restrict reprogramming potential in differentiated cells. | Missinato MA et al. | — | 2023 | → |
| Direct cardiac reprogramming: A new technology for cardiac repair. | Brlecic PE et al. | — | 2023 | → |
| Direct Conversion of Fibroblast into Neurons for Alzheimer's Disease Research: A Systematic Review. | Sattarov R et al. | — | 2023 | → |
| Direct Lineage Reprogramming for Induced Keratinocyte Stem Cells: A Potential Approach for Skin Repair. | Lin H et al. | — | 2023 | → |
| Direct neuronal reprogramming by temporal identity factors. | Boudreau-Pinsonneault C et al. | — | 2023 | → |
| Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factors. | Fontcuberta-PiSunyer M et al. | — | 2023 | → |
| Diverse heterochromatin states restricting cell identity and reprogramming. | McCarthy RL et al. | — | 2023 | → |
| DOT1L is a barrier to histone acetylation during reprogramming to pluripotency. | Wille CK et al. | — | 2023 | → |
| Echinoderm radial glia in adult cell renewal, indeterminate growth, and regeneration. | Mashanov V et al. | — | 2023 | → |
| Efficient Generation of Dopaminergic Neurons from Mouse Ventral Midbrain Astrocytes. | Han JY et al. | — | 2023 | → |
| Efficient generation of functional neurons from mouse embryonic stem cells via neurogenin-2 expression. | Liu Y et al. | — | 2023 | → |
| Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues. | Limone F et al. | — | 2023 | → |
| Endothelial cell direct reprogramming: Past, present, and future. | Cho S et al. | — | 2023 | → |
| From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome. | Watson LA et al. | — | 2023 | → |
| Functional bioengineered models of the central nervous system. | Rouleau N et al. | — | 2023 | → |
| Generation of self-organized autonomic ganglion organoids from fibroblasts. | Liu S et al. | — | 2023 | → |
| Gene Therapy Using Efficient Direct Lineage Reprogramming Technology for Neurological Diseases. | Chang Y et al. | — | 2023 | → |
| H3K36 methylation maintains cell identity by regulating opposing lineage programmes. | Hoetker MS et al. | — | 2023 | → |
| Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer's Disease. | Young JE et al. | — | 2023 | → |
| Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming. | Agarwal D et al. | — | 2023 | → |
| <i>Bcl</i>-<i>xL</i> Promotes the Survival of Motor Neurons Derived from Neural Stem Cells. | Wu Y et al. | — | 2023 | → |
| Identifying Cancer Type-Specific Transcriptional Programs through Network Analysis. | Kurup JT et al. | — | 2023 | → |
| Identifying Molecular Roadblocks for Transcription Factor-Induced Cellular Reprogramming In Vivo by Using <i>C. elegans</i> as a Model Organism. | Özcan I et al. | — | 2023 | → |
| Improved Cardiac Function in Postischemic Rats Using an Optimized Cardiac Reprogramming Cocktail Delivered in a Single Novel Adeno-Associated Virus. | Zhou H et al. | — | 2023 | → |
| Improving Efficiency of Direct Pro-Neural Reprogramming: Much-Needed Aid for Neuroregeneration in Spinal Cord Injury. | Chudakova DA et al. | — | 2023 | → |
| Inferring regulators of cell identity in the human adult pancreas. | Vanheer L et al. | — | 2023 | → |
| Insights and applications of direct neuronal reprogramming. | Schaukowitch K et al. | — | 2023 | → |
| Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings. | Hicks EM et al. | — | 2023 | → |
| Label-Free Long-Term Methods for Live Cell Imaging of Neurons: New Opportunities. | Baričević Z et al. | — | 2023 | → |
| Lama2 And Samsn1 Mediate the Effects of Brn4 on Hippocampal Neural Stem Cell Proliferation and Differentiation. | Zhang L et al. | — | 2023 | → |
| Lineage tracing identifies in vitro microglia-to-neuron conversion by NeuroD1 expression. | Irie T et al. | — | 2023 | → |
| Low glutaminase and glycolysis correlate with a high transdifferentiation efficiency in mouse cortex. | Li Y et al. | — | 2023 | → |
| MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention. | Weigel B et al. | — | 2023 | → |
| MYT1L is required for suppressing earlier neuronal development programs in the adult mouse brain. | Chen J et al. | — | 2023 | → |
| Neurod1 mediates the reprogramming of NG2 glial into neurons in vitro. | Wei M et al. | — | 2023 | → |
| Oxytocin Receptor Expression in Hair Follicle Stem Cells: A Promising Model for Biological and Therapeutic Discovery in Neuropsychiatric Disorders. | Pandamooz S et al. | — | 2023 | → |
| Patient-Derived Cellular Models for Polytarget Precision Medicine in Pantothenate Kinase-Associated Neurodegeneration. | Álvarez-Córdoba M et al. | — | 2023 | → |
| Patient-derived iPSC models of Friedreich ataxia: a new frontier for understanding disease mechanisms and therapeutic application. | Maheshwari S et al. | — | 2023 | → |
| PAX3-FOXO1 dictates myogenic reprogramming and rhabdomyosarcoma identity in endothelial progenitors. | Searcy MB et al. | — | 2023 | → |
| Physicochemical cues are not potent regulators of human dermal fibroblast trans-differentiation. | Ryan CNM et al. | — | 2023 | → |
| Programming human cell fate: overcoming challenges and unlocking potential through technological breakthroughs. | Lin HC et al. | — | 2023 | → |
| Protocol Optimization for Direct Reprogramming of Primary Human Fibroblast into Induced Striatal Neurons. | Kraskovskaya N et al. | — | 2023 | → |
| Recent advances and future prospects in direct cardiac reprogramming. | Xie Y et al. | — | 2023 | → |
| Reduction of Intracellular Tension and Cell Adhesion Promotes Open Chromatin Structure and Enhances Cell Reprogramming. | Soto J et al. | — | 2023 | → |
| Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy. | Linde MH et al. | — | 2023 | → |
| Reprogramming Cell Identity: Past Lessons, Challenges, and Future Directions. | Silva JCR | — | 2023 | → |
| Reprogramming of cardiac cell fate as a therapeutic strategy for ischemic heart disease. | Garry GA et al. | — | 2023 | → |
| Retinal Ganglion Cells in a Dish: Current Strategies and Recommended Best Practices for Effective In Vitro Modeling of Development and Disease. | Huang KC et al. | — | 2023 | → |
| Simple, Fast, and Efficient Method for Derivation of Dermal Fibroblasts From Skin Biopsies. | Iannello G et al. | — | 2023 | → |
| Single-cell epigenome analysis identifies molecular events controlling direct conversion of human fibroblasts to pancreatic ductal-like cells. | Fei L et al. | — | 2023 | → |
| Small molecules fail to induce direct reprogramming of adult rat olfactory ensheathing glia to mature neurons. | Portela-Lomba M et al. | — | 2023 | → |
| Spinal Cord Organoids to Study Motor Neuron Development and Disease. | Buchner F et al. | — | 2023 | → |
| Spontaneous and familial models of Alzheimer's disease: Challenges and advances in preclinical research. | Ulaganathan S et al. | — | 2023 | → |
| Stem Cell Models for Context-Specific Modeling in Psychiatric Disorders. | Seah C et al. | — | 2023 | → |
| Stem cell programming - prospects for perinatal medicine. | Berg LJ et al. | — | 2023 | → |
| Strategies and mechanisms of neuronal reprogramming. | Wan Y et al. | — | 2023 | → |
| Systems Medicine as a Strategy to Deal with Alzheimer's Disease. | Zeng XX et al. | — | 2023 | → |
| The bHLH transcription factor ASCL1 promotes differentiation of endocrine cells in the stomach and is regulated by Notch signaling. | Hibdon ES et al. | — | 2023 | → |
| The circadian regulator PER1 promotes cell reprogramming by inhibiting inflammatory signaling from macrophages. | Katoku-Kikyo N et al. | — | 2023 | → |
| The homeodomain of Oct4 is a dimeric binder of methylated CpG elements. | Tan DS et al. | — | 2023 | → |
| The latest role of nerve-specific splicing factor PTBP1 in the transdifferentiation of glial cells into neurons. | Chen XD et al. | — | 2023 | → |
| The role of pioneer transcription factors in the induction of direct cellular reprogramming. | Horisawa K et al. | — | 2023 | → |
| The Wisdom in Teeth: Neuronal Differentiation of Dental Pulp Cells. | Sramkó B et al. | — | 2023 | → |
| Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature. | Horisawa K et al. | — | 2023 | → |
| Translational landscape of direct cardiac reprogramming reveals a role of Ybx1 in repressing cardiac fate acquisition. | Xie Y et al. | — | 2023 | → |
| Use of <i>in vitro</i> derived human neuronal models to study host-parasite interactions of <i>Toxoplasma gondii</i> in neurons and neuropathogenesis of chronic toxoplasmosis. | Halonen SK | — | 2023 | → |
| Virtual Screening-Based Drug Development for the Treatment of Nervous System Diseases. | Li Q et al. | — | 2023 | → |
| WMDS.net: a network control framework for identifying key players in transcriptome programs. | Cheng X et al. | — | 2023 | → |
| 100 plus years of stem cell research-20 years of ISSCR. | Lendahl U | — | 2022 | → |
| Accelerated neuronal aging <i>in vitro</i> ∼melting watch ∼. | Inagaki E et al. | — | 2022 | → |
| Activity-Dependent Induction of Younger Biological Phenotypes. | Lissek T | — | 2022 | → |
| An Isogenic Collection of Pluripotent Stem Cell Lines With Elevated α-Synuclein Expression Validated for Neural Induction and Cortical Neuron Differentiation. | Natalwala A et al. | — | 2022 | → |
| Application and prospects of high-throughput screening for <i>in vitro</i> neurogenesis. | Zhang SY et al. | — | 2022 | → |
| Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment. | Yang R et al. | — | 2022 | → |
| Application of Small Molecules in the Central Nervous System Direct Neuronal Reprogramming. | Wang J et al. | — | 2022 | → |
| Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes <i>in vivo</i>. | Ghazale H et al. | — | 2022 | → |
| A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor development. | Benedetti V et al. | — | 2022 | → |
| Astragalus Flavone Induces Proliferation and Differentiation of Neural Stem Cells in a Cerebral Infarction Model. | Gao H et al. | — | 2022 | → |
| A subterminal growth zone at arm tip likely underlies life-long indeterminate growth in brittle stars. | Mashanov V et al. | — | 2022 | → |
| Building in vitro models of the brain to understand the role of <i>APOE</i> in Alzheimer's disease. | Pinals RL et al. | — | 2022 | → |
| Cell models for Down syndrome-Alzheimer's disease research. | Wu Y et al. | — | 2022 | → |
| CELLoGeNe - An energy landscape framework for logical networks controlling cell decisions. | Andersson E et al. | — | 2022 | → |
| Cell Reprogramming for Regeneration and Repair of the Nervous System. | Clark IH et al. | — | 2022 | → |
| Cellular Reprogramming and Its Potential Application in Alzheimer's Disease. | Zhou C et al. | — | 2022 | → |
| Changing Fate: Reprogramming Cells via Engineered Nanoscale Delivery Materials. | Soltani Dehnavi S et al. | — | 2022 | → |
| Chemically induced senescence in human stem cell-derived neurons promotes phenotypic presentation of neurodegeneration. | Fathi A et al. | — | 2022 | → |
| Combinatorial Approach of Binary Colloidal Crystals and CRISPR Activation to Improve Induced Pluripotent Stem Cell Differentiation into Neurons. | Urrutia-Cabrera D et al. | — | 2022 | → |
| Comparative roadmaps of reprogramming and oncogenic transformation identify Bcl11b and Atoh8 as broad regulators of cellular plasticity. | Huyghe A et al. | — | 2022 | → |
| Computational approaches for direct cell reprogramming: from the bulk omics era to the single cell era. | Tran A et al. | — | 2022 | → |
| Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes. | Wang H et al. | — | 2022 | → |
| "Cutting the Mustard" with Induced Pluripotent Stem Cells: An Overview and Applications in Healthcare Paradigm. | Behl T et al. | — | 2022 | → |
| Designer Extracellular Vesicles Modulate Pro-Neuronal Cell Responses and Improve Intracranial Retention. | Ortega-Pineda L et al. | — | 2022 | → |
| Dimerization of PtrMYB074 and PtrWRKY19 mediates transcriptional activation of PtrbHLH186 for secondary xylem development in Populus trichocarpa. | Liu H et al. | — | 2022 | → |
| Direct cardiac reprogramming comes of age: Recent advance and remaining challenges. | Xie Y et al. | — | 2022 | → |
| Direct Cell Conversion of Somatic Cells into Dopamine Neurons: Achievements and Perspectives. | Aversano S et al. | — | 2022 | → |
| Direct Conversion of Cell Fate and Induced Endothelial Cells. | Han JK et al. | — | 2022 | → |
| Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches. | Bocchi R et al. | — | 2022 | → |
| Diseased, differentiated and difficult: Strategies for improved engineering of <i>in vitro</i> neurological systems. | Elder N et al. | — | 2022 | → |
| Disease Modeling of Neurodegenerative Disorders Using Direct Neural Reprogramming. | Legault EM et al. | — | 2022 | → |
| Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins. | Zheng L et al. | — | 2022 | → |
| Dynamics and Pathways of Chromosome Structural Organizations during Cell Transdifferentiation. | Chu X et al. | — | 2022 | → |
| Elevated ASCL1 activity creates de novo regulatory elements associated with neuronal differentiation. | Woods LM et al. | — | 2022 | → |
| Elongated nanoporous Au networks improve somatic cell direct conversion into induced dopaminergic neurons for Parkinson's disease therapy. | Lee S et al. | — | 2022 | → |
| Embryoid Body Formation from Mouse and Human Pluripotent Stem Cells for Transplantation to Study Brain Microenvironment and Cellular Differentiation. | Guerra-Crespo M et al. | — | 2022 | → |
| Expression level of the reprogramming factor NeuroD1 is critical for neuronal conversion efficiency from different cell types. | Matsuda-Ito K et al. | — | 2022 | → |
| Expression of myelin transcription factor 1 and lamin B receptor mediate neural progenitor fate transition in the zebrafish spinal cord pMN domain. | Xing L et al. | — | 2022 | → |
| Foxa2 and Pet1 Direct and Indirect Synergy Drive Serotonergic Neuronal Differentiation. | Aydin B et al. | — | 2022 | → |
| Function of Proneural Genes Ascl1 and Asense in Neurogenesis: How Similar Are They? | Soares DS et al. | — | 2022 | → |
| Generation and Application of Directly Reprogrammed Endothelial Cells. | Jung C et al. | — | 2022 | → |
| Generation of a Pure Culture of Neuron-like Cells with a Glutamatergic Phenotype from Mouse Astrocytes. | Fernandes GS et al. | — | 2022 | → |
| Gene Therapy Approach with an Emphasis on Growth Factors: Theoretical and Clinical Outcomes in Neurodegenerative Diseases. | Parambi DGT et al. | — | 2022 | → |
| Genetic and Epigenetic Interplay Define Disease Onset and Severity in Repeat Diseases. | Barbé L et al. | — | 2022 | → |
| Genetic Mechanism Study of Auditory Phoenix Spheres and Transcription Factors Prediction for Direct Reprogramming by Bioinformatics. | Chen J et al. | — | 2022 | → |
| Harnessing the Power of Stem Cell Models to Study Shared Genetic Variants in Congenital Heart Diseases and Neurodevelopmental Disorders. | Chang X et al. | — | 2022 | → |
| Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG. | Lewis NA et al. | — | 2022 | → |
| Human Brain-Based Models Provide a Powerful Tool for the Advancement of Parkinson's Disease Research and Therapeutic Development. | McComish SF et al. | — | 2022 | → |
| Huntington's disease iPSC models-using human patient cells to understand the pathology caused by expanded CAG repeats. | Kaye J et al. | — | 2022 | → |
| Identification of a new way to induce differentiation of dermal fibroblasts into vascular endothelial cells. | Cui X et al. | — | 2022 | → |
| Impact of Mitochondrial A3243G Heteroplasmy on Mitochondrial Bioenergetics and Dynamics of Directly Reprogrammed MELAS Neurons. | Lin DS et al. | — | 2022 | → |
| Indirect Mechanisms of Transcription Factor-Mediated Gene Regulation during Cell Fate Changes. | Larcombe MR et al. | — | 2022 | → |
| Induced Dopaminergic Neurons for Parkinson's Disease Therapy: Targeting the Striatum or Midbrain/Substantia Nigra Pars Compacta? | Xu H et al. | — | 2022 | → |
| Induced pluripotent stem cell-derived and directly reprogrammed neurons to study neurodegenerative diseases: The impact of aging signatures. | Aversano S et al. | — | 2022 | → |
| Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer. | Kelenis DP et al. | — | 2022 | → |
| Integrative molecular roadmap for direct conversion of fibroblasts into myocytes and myogenic progenitor cells. | Kim I et al. | — | 2022 | → |
| In vivo reprogramming as a new approach to cardiac regenerative therapy. | Sadahiro T et al. | — | 2022 | → |
| iPSCs in Neurodegenerative Disorders: A Unique Platform for Clinical Research and Personalized Medicine. | Pandey S et al. | — | 2022 | → |
| Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation. | Pulcrano S et al. | — | 2022 | → |
| Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs. | Sanchez-Priego C et al. | — | 2022 | → |
| Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation. | Kreimer A et al. | — | 2022 | → |
| Measuring transcription factor binding and gene expression using barcoded self-reporting transposon calling cards and transcriptomes. | Lalli M et al. | — | 2022 | → |
| Melatonin and the Programming of Stem Cells. | Hardeland R | — | 2022 | → |
| Melatonin attenuates dimethyl sulfoxide- and Zika virus-induced degeneration of porcine induced neural stem cells. | Horcharoensuk P et al. | — | 2022 | → |
| MicroRNA Roles in Cell Reprogramming Mechanisms. | Pascale E et al. | — | 2022 | → |
| Mitochondrial dysfunction of induced pluripotent stem cells-based neurodegenerative disease modeling and therapeutic strategy. | Luo HM et al. | — | 2022 | → |
| Modeling Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome Using Patient-Derived Induced Neurons Generated by Direct Reprogramming. | Povea-Cabello S et al. | — | 2022 | → |
| Morphometric imaging biomarker identifies Alzheimer's disease even among mixed dementia patients. | Chirila FV et al. | — | 2022 | → |
| MYT1L-associated neurodevelopmental disorder: description of 40 new cases and literature review of clinical and molecular aspects. | Coursimault J et al. | — | 2022 | → |
| Myt1l haploinsufficiency leads to obesity and multifaceted behavioral alterations in mice. | Wöhr M et al. | — | 2022 | → |
| MYT1L in the making: emerging insights on functions of a neurodevelopmental disorder gene. | Chen J et al. | — | 2022 | → |
| Oligodendroglia Generated From Adult Rat Adipose Tissue by Direct Cell Conversion. | Vellosillo L et al. | — | 2022 | → |
| Parkinson's disease motor symptoms rescue by CRISPRa-reprogramming astrocytes into GABAergic neurons. | Giehrl-Schwab J et al. | — | 2022 | → |
| Past, Present, and Future of Direct Cell Reprogramming. | Ahlenius H | — | 2022 | → |
| Patient-Specific iPSCs-Based Models of Neurodegenerative Diseases: Focus on Aberrant Calcium Signaling. | Grekhnev DA et al. | — | 2022 | → |
| Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons. | He ZQ et al. | — | 2022 | → |
| Phenotypic plasticity during metastatic colonization. | Jehanno C et al. | — | 2022 | → |
| Pioneer factors as master regulators of the epigenome and cell fate. | Balsalobre A et al. | — | 2022 | → |
| Polyphenols as potential enhancers of stem cell therapy against neurodegeneration. | Rodríguez-Vera D et al. | — | 2022 | → |
| Postnatal age-differential ASD-like transcriptomic, synaptic, and behavioral deficits in Myt1l-mutant mice. | Kim S et al. | — | 2022 | → |
| Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity. | Ma X et al. | — | 2022 | → |
| Probabilistic boolean networks predict transcription factor targets to induce transdifferentiation. | Tercan B et al. | — | 2022 | → |
| Probing cell identity hierarchies by fate titration and collision during direct reprogramming. | Hersbach BA et al. | — | 2022 | → |
| Rapid Conversion of Human Induced Pluripotent Stem Cells into Dopaminergic Neurons by Inducible Expression of Two Transcription Factors. | Nishimura K et al. | — | 2022 | → |
| Regulation of Neural Differentiation of ADMSCs using Graphene-Mediated Wireless-Localized Electrical Signals Driven by Electromagnetic Induction. | Guo Z et al. | — | 2022 | → |
| Repurposing the lineage-determining transcription factor Atoh1 without redistributing its genomic binding sites. | Costa A et al. | — | 2022 | → |
| Restoration of spinal cord injury: From endogenous repairing process to cellular therapy. | Wu Y et al. | — | 2022 | → |
| Revealing the Impact of Mitochondrial Fitness During Early Neural Development Using Human Brain Organoids. | Romero-Morales AI et al. | — | 2022 | → |
| Reversibility and therapeutic development for neurodevelopmental disorders, insights from genetic animal models. | Megagiannis P et al. | — | 2022 | → |
| Role of the Transcription Factor MAFA in the Maintenance of Pancreatic β-Cells. | Nishimura W et al. | — | 2022 | → |
| Somatic Lineage Reprogramming. | Shelby H et al. | — | 2022 | → |
| Spinal motor neuron transplantation to enhance nerve reconstruction strategies: Towards a cell therapy. | Bazarek S et al. | — | 2022 | → |
| St18 specifies globus pallidus projection neuron identity in MGE lineage. | Nunnelly LF et al. | — | 2022 | → |
| Stem-like T cells and niches: Implications in human health and disease. | Yi L et al. | — | 2022 | → |
| Strategies of pluripotent stem cell-based therapy for retinal degeneration: update and challenges. | Maeda T et al. | — | 2022 | → |
| Targeting PTB for Glia-to-Neuron Reprogramming In Vitro and In Vivo for Therapeutic Development in Neurological Diseases. | Contardo M et al. | — | 2022 | → |
| The Art of Reprogramming for Regenerative Medicine. | Kuang J et al. | — | 2022 | → |
| The bHLH Transcription Factors in Neural Development and Therapeutic Applications for Neurodegenerative Diseases. | Lee DG et al. | — | 2022 | → |
| The use of fibroblasts as a valuable strategy for studying mitochondrial impairment in neurological disorders. | Olesen MA et al. | — | 2022 | → |
| Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation. | Janas JA et al. | — | 2022 | → |
| Transcription Factors with Targeting Potential in Gliomas. | Giannopoulou AI et al. | — | 2022 | → |
| TRANSDIRE: data-driven direct reprogramming by a pioneer factor-guided trans-omics approach. | Eguchi R et al. | — | 2022 | → |
| Transient nuclear deformation primes epigenetic state and promotes cell reprogramming. | Song Y et al. | — | 2022 | → |
| Uncovering the Quantitative Relationships Among Chromosome Fluctuations, Epigenetics, and Gene Expressions of Transdifferentiation on Waddington Landscape. | Chu WT et al. | — | 2022 | → |
| VLDLR and ApoER2 are receptors for multiple alphaviruses. | Clark LE et al. | — | 2022 | → |
| A computer-guided design tool to increase the efficiency of cellular conversions. | Jung S et al. | — | 2021 | → |
| Advancing models of neural development with biomaterials. | Roth JG et al. | — | 2021 | → |
| A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation. | Chen J et al. | — | 2021 | → |
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| Direct Conversion of Human Fibroblasts to Induced Neurons. | Zhou-Yang L et al. | — | 2021 | → |
| Direct conversion of porcine primary fibroblasts into hepatocyte-like cells. | Fráguas-Eggenschwiler M et al. | — | 2021 | → |
| Direct Differentiation of Functional Neurons from Human Pluripotent Stem Cells (hPSCs). | Hu R et al. | — | 2021 | → |
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| Directly Reprogrammed Neurons as a Tool to Assess Neurotoxicity of the Contaminant 4-Hydroxy-2',3,5,5'-tetrachlorobiphenyl (4'OH-CB72) in Melon-Headed Whales. | Ochiai M et al. | — | 2021 | → |
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| Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture. | Lattke M et al. | — | 2021 | → |
| Functional Assessment of Direct Reprogrammed Neurons In Vitro and In Vivo. | Kidnapillai S et al. | — | 2021 | → |
| Generation of Human iPSC-derived Neural Progenitor Cells (NPCs) as Drug Discovery Model for Neurological and Mitochondrial Disorders. | Zink A et al. | — | 2021 | → |
| Generation of Induced Dopaminergic Neurons from Human Fetal Fibroblasts. | Legault EM et al. | — | 2021 | → |
| Generation of Induced Nephron Progenitor-like Cells from Human Urine-Derived Cells. | Gao WW et al. | — | 2021 | → |
| Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments. | Zhang X et al. | — | 2021 | → |
| Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2. | Kempf J et al. | — | 2021 | → |
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| Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging. | Chao CC et al. | — | 2021 | → |
| Human mini-brain models. | Tan HY et al. | — | 2021 | → |
| Human Neural Stem Cells for Cell-Based Medicinal Products. | Fernandez-Muñoz B et al. | — | 2021 | → |
| Human stem cell models to study host-virus interactions in the central nervous system. | Harschnitz O et al. | — | 2021 | → |
| Hypothesis and Theory: Characterizing Abnormalities of Energy Metabolism Using a Cellular Platform as a Personalized Medicine Approach for Alzheimer's Disease. | Ryu WI et al. | — | 2021 | → |
| <i>In vivo</i> Direct Conversion of Astrocytes to Neurons Maybe a Potential Alternative Strategy for Neurodegenerative Diseases. | Wang Y et al. | — | 2021 | → |
| Improved Method for Efficient Generation of Functional Neurons from Murine Neural Progenitor Cells. | Soni A et al. | — | 2021 | → |
| Injury-induced ASCL1 expression orchestrates a transitory cell state required for repair of the neonatal cerebellum. | Bayin NS et al. | — | 2021 | → |
| In Silico Analysis to Explore Lineage-Independent and -Dependent Transcriptional Programs Associated with the Process of Endothelial and Neural Differentiation of Human Induced Pluripotent Stem Cells. | Nakhaei-Nejad M et al. | — | 2021 | → |
| Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification. | Liu KC et al. | — | 2021 | → |
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| In Vitro Conversion of Murine Fibroblasts into Cardiomyocyte-Like Cells. | Xu J et al. | — | 2021 | → |
| Isolation and Neuronal Reprogramming of Mouse Embryonic Fibroblasts. | Adrian-Segarra JM et al. | — | 2021 | → |
| Lineage tracing of direct astrocyte-to-neuron conversion in the mouse cortex. | Xiang Z et al. | — | 2021 | → |
| Making Sense of Patient-Derived iPSCs, Transdifferentiated Neurons, Olfactory Neuronal Cells, and Cerebral Organoids as Models for Psychiatric Disorders. | Unterholzner J et al. | — | 2021 | → |
| Management of oxidative stress and inflammation in cardiovascular diseases: mechanisms and challenges. | Donia T et al. | — | 2021 | → |
| Mash-1 modified neural stem cells transplantation promotes neural stem cells differentiation into neurons to further improve locomotor functional recovery in spinal cord injury rats. | Deng M et al. | — | 2021 | → |
| Modulating the Electrical and Mechanical Microenvironment to Guide Neuronal Stem Cell Differentiation. | Oh B et al. | — | 2021 | → |
| Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo. | Sönmezer C et al. | — | 2021 | → |
| Molecular Mechanisms Underlying Ascl1-Mediated Astrocyte-to-Neuron Conversion. | Rao Z et al. | — | 2021 | → |
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| Neurotransmitter Release of Reprogrammed Cells Using Electrochemical Detection Methods. | Heuer A | — | 2021 | → |
| New Insights Into the Intricacies of Proneural Gene Regulation in the Embryonic and Adult Cerebral Cortex. | Oproescu AM et al. | — | 2021 | → |
| On the origins and conceptual frameworks of natural plasticity-Lessons from single-cell models in C. elegans. | Lambert J et al. | — | 2021 | → |
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| Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity. | Sorek M et al. | — | 2021 | → |
| Reactivation of the Hedgehog pathway in esophageal progenitors turns on an embryonic-like program to initiate columnar metaplasia. | Vercauteren Drubbel A et al. | — | 2021 | → |
| Regulation of Adult Mammalian Neural Stem Cells and Neurogenesis by Cell Extrinsic and Intrinsic Factors. | Matsubara S et al. | — | 2021 | → |
| Rejuvenated Stem/Progenitor Cells for Cartilage Repair Using the Pluripotent Stem Cell Technology. | Nakayama N et al. | — | 2021 | → |
| Reprogramming astrocytes to motor neurons by activation of endogenous Ngn2 and Isl1. | Zhou M et al. | — | 2021 | → |
| Reprogramming Glial Cells into Functional Neurons for Neuro-regeneration: Challenges and Promise. | Wang F et al. | — | 2021 | → |
| Reprogramming Human Adult Fibroblasts into GABAergic Interneurons. | Bruzelius A et al. | — | 2021 | → |
| Reprogramming Stars #4: A Reprogramming Approach for Parkinson's Disease-An Interview with Dr. Malin Parmar. | Parmar M et al. | — | 2021 | → |
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| Screening Platforms for Genetic Epilepsies-Zebrafish, iPSC-Derived Neurons, and Organoids. | Shcheglovitov A et al. | — | 2021 | → |
| Single-Cell Genomics: Catalyst for Cell Fate Engineering. | Li B et al. | — | 2021 | → |
| Stepwise Induction of Inner Ear Hair Cells From Mouse Embryonic Fibroblasts via Mesenchymal- to-Epithelial Transition and Formation of Otic Epithelial Cells. | Yang Q et al. | — | 2021 | → |
| Suppression of canonical TGF-β signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis. | Riching AS et al. | — | 2021 | → |
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| Targeting neurotransmitter-mediated inflammatory mechanisms of psychiatric drugs to mitigate the double burden of multimorbidity and polypharmacy. | Matt SM | — | 2021 | → |
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| The Inside-Out of End-Stage Liver Disease: Hepatocytes are the Keystone. | Haep N et al. | — | 2021 | → |
| The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models. | MacDougall G et al. | — | 2021 | → |
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| The Role of Astrocytes in the Neurorepair Process. | Chiareli RA et al. | — | 2021 | → |
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| Transcription Factor Reprogramming in the Inner Ear: Turning on Cell Fate Switches to Regenerate Sensory Hair Cells. | Iyer AA et al. | — | 2021 | → |
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| Activated HoxB4-induced hematopoietic stem cells from murine pluripotent stem cells via long-term programming. | Izawa K et al. | — | 2020 | → |
| ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress. | Guallar D et al. | — | 2020 | → |
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| Advances in Human Stem Cells and Genome Editing to Understand and Develop Treatment for Fragile X Syndrome. | Zhao X et al. | — | 2020 | → |
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| Cell Reprogramming Preserving Epigenetic Age: Advantages and Limitations. | Samoylova EM et al. | — | 2020 | → |
| Cell therapy for central nervous system disorders: Current obstacles to progress. | Yasuhara T et al. | — | 2020 | → |
| Chitosan-<i>g</i>-oligo(L,L-lactide) Copolymer Hydrogel Potential for Neural Stem Cell Differentiation. | Revkova VA et al. | — | 2020 | → |
| Conjunctival goblet cells: Ocular surface functions, disorders that affect them, and the potential for their regeneration. | Swamynathan SK et al. | — | 2020 | → |
| Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity. | Clark EA et al. | — | 2020 | → |
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| Cytokine Directed Chondroblast Trans-Differentiation: <i>JAK</i> Inhibition Facilitates Direct Reprogramming of Fibroblasts to Chondroblasts. | Cota P et al. | — | 2020 | → |
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| Direct conversion of somatic cells towards oligodendroglial lineage cells: A novel strategy for enhancement of myelin repair. | Yavarpour-Bali H et al. | — | 2020 | → |
| Direct Lineage Reprogramming in the CNS. | Bajohr J et al. | — | 2020 | → |
| Direct Neuronal Reprogramming of Common Marmoset Fibroblasts by ASCL1, microRNA-9/9*, and microRNA-124 Overexpression. | Nemoto A et al. | — | 2020 | → |
| Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons. | Nolbrant S et al. | — | 2020 | → |
| Direct Reprogramming of Mouse Fibroblasts into Functional Osteoblasts. | Zhu H et al. | — | 2020 | → |
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| Extracellular Matrix and Cellular Plasticity in Musculoskeletal Development. | Ma SKY et al. | — | 2020 | → |
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| Five transcriptional factors reprogram fibroblast into myogenic lineage cells via paraxial mesoderm stage. | Hwang M et al. | — | 2020 | → |
| Forskolin rapidly enhances neuron-like morphological change of directly induced-neuronal cells from neurofibromatosis type 1 patients. | Sagata N et al. | — | 2020 | → |
| From in vitro to in vivo reprogramming for neural transdifferentiation: An approach for CNS tissue remodeling using stem cell technology. | Egawa N et al. | — | 2020 | → |
| Full small molecule conversion of human fibroblasts to neuroectodermal cells via a cocktail of Dorsomorphin and Trichostatin A. | Hosseini Farahabadi SS et al. | — | 2020 | → |
| Functional Comparison of Blood-Derived Human Neural Progenitor Cells. | Szabó E et al. | — | 2020 | → |
| Gap Junction Dependent Cell Communication Is Modulated During Transdifferentiation of Mesenchymal Stem/Stromal Cells Towards Neuron-Like Cells. | Dilger N et al. | — | 2020 | → |
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| Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington's disease. | Wu Z et al. | — | 2020 | → |
| Human Dermal Fibroblast: A Promising Cellular Model to Study Biological Mechanisms of Major Depression and Antidepressant Drug Response. | Mesdom P et al. | — | 2020 | → |
| Human Induced Pluripotent Stem Cell Models of Neurodegenerative Disorders for Studying the Biomedical Implications of Autophagy. | Seranova E et al. | — | 2020 | → |
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| Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer. | Corella AN et al. | — | 2020 | → |
| Insights Into the Role and Potential of Schwann Cells for Peripheral Nerve Repair From Studies of Development and Injury. | Balakrishnan A et al. | — | 2020 | → |
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| Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells. | Bäuerlein FJB et al. | — | 2020 | → |
| Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells. | Powell SK et al. | — | 2020 | → |
| In vivo combinatory gene therapy synergistically promotes cardiac function and vascular regeneration following myocardial infarction. | Lee S et al. | — | 2020 | → |
| Involvement of <i>HB-EGF/Ascl1/Lin28a</i> Genes in Dedifferentiation of Adult Mammalian Müller Glia. | Stanchfield ML et al. | — | 2020 | → |
| iPSC modeling of rare pediatric disorders. | Freel BA et al. | — | 2020 | → |
| KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain. | Lipinski M et al. | — | 2020 | → |
| KMT2B and Neuronal Transdifferentiation: Bridging Basic Chromatin Mechanisms to Disease Actionability. | Barbagiovanni G et al. | — | 2020 | → |
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| Mapping Gene Circuits Essential for Germ Layer Differentiation via Loss-of-Function Screens in Haploid Human Embryonic Stem Cells. | Yilmaz A et al. | — | 2020 | → |
| Master Regulators and Cofactors of Human Neuronal Cell Fate Specification Identified by CRISPR Gene Activation Screens. | Black JB et al. | — | 2020 | → |
| Method to combat Parkinson's disease by astrocyte-to-neuron conversion. | Arenas E | — | 2020 | → |
| MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons. | Habekost M et al. | — | 2020 | → |
| miRNA-Based Rapid Differentiation of Purified Neurons from hPSCs Advancestowards Quick Screening for Neuronal Disease Phenotypes In Vitro. | Ishikawa M et al. | — | 2020 | → |
| Modeling Brain Disorders Using Induced Pluripotent Stem Cells. | Vadodaria KC et al. | — | 2020 | → |
| Modeling Psychiatric Disorder Biology with Stem Cells. | Das D et al. | — | 2020 | → |
| Modelling frontotemporal dementia using patient-derived induced pluripotent stem cells. | Lines G et al. | — | 2020 | → |
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| Neurodegeneration in a dish: advancing human stem-cell-based models of Alzheimer's disease. | Klimmt J et al. | — | 2020 | → |
| Neurogenic Niche Conversion Strategy Induces Migration and Functional Neuronal Differentiation of Neural Precursor Cells Following Brain Injury. | Wang Z et al. | — | 2020 | → |
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| Novel Glial Cell Functions: Extensive Potency, Stem Cell-Like Properties, and Participation in Regeneration and Transdifferentiation. | Milichko V et al. | — | 2020 | → |
| Novel insights into inner ear development and regeneration for targeted hearing loss therapies. | Roccio M et al. | — | 2020 | → |
| Nuclear actin and myosin in chromatin regulation and maintenance of genome integrity. | Venit T et al. | — | 2020 | → |
| Organoid and pluripotent stem cells in Parkinson's disease modeling: an expert view on their value to drug discovery. | Marotta N et al. | — | 2020 | → |
| Overcoming Current Dilemma in Cartilage Regeneration: Will Direct Conversion Provide a Breakthrough? | Im GI et al. | — | 2020 | → |
| Pharmacologic fibroblast reprogramming into photoreceptors restores vision. | Mahato B et al. | — | 2020 | → |
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| Protein-based direct reprogramming of fibroblasts to neuronal cells using 30Kc19 protein and transcription factor Ascl1. | Ryu J et al. | — | 2020 | → |
| Quick Commitment and Efficient Reprogramming Route of Direct Induction of Retinal Ganglion Cell-like Neurons. | Wang J et al. | — | 2020 | → |
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| The iNs and Outs of Direct Reprogramming to Induced Neurons. | Carter JL et al. | — | 2020 | → |
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| Understanding and Engineering Chromatin as a Dynamical System across Length and Timescales. | Johnstone CP et al. | — | 2020 | → |
| Using brain organoids to study human neurodevelopment, evolution and disease. | Kyrousi C et al. | — | 2020 | → |
| Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases. | Zhang X et al. | — | 2020 | → |
| Visualizing the Synaptic and Cellular Ultrastructure in Neurons Differentiated from Human Induced Neural Stem Cells-An Optimized Protocol. | Capetian P et al. | — | 2020 | → |
| What we can learn from iPSC-derived cellular models of Parkinson's disease. | Caiazza MC et al. | — | 2020 | → |
| Whole brain delivery of an instability-prone <i>Mecp2</i> transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome. | Luoni M et al. | — | 2020 | → |
| 17-β estradiol exerts anti-inflammatory effects through activation of Nrf2 in mouse embryonic fibroblasts. | Song CH et al. | — | 2019 | → |
| A common molecular logic determines embryonic stem cell self-renewal and reprogramming. | Dunn SJ et al. | — | 2019 | → |
| Acquisition of functional neurons by direct conversion: Switching the developmental clock directly. | Chen S et al. | — | 2019 | → |
| A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport. | Shlevkov E et al. | — | 2019 | → |
| Alternative 3' UTRs direct localization of functionally diverse protein isoforms in neuronal compartments. | Ciolli Mattioli C et al. | — | 2019 | → |
| Alzheimer's in a dish - induced pluripotent stem cell-based disease modeling. | de Leeuw S et al. | — | 2019 | → |
| A master regulator of regeneration. | Alonge M et al. | — | 2019 | → |
| A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes. | Lee J et al. | — | 2019 | → |
| Analysis of pituitary adenoma expression patterns suggests a potential role for the NeuroD1 transcription factor in neuroendocrine tumor-targeting therapies. | Mitrofanova LB et al. | — | 2019 | → |
| Antioxidant Regulation of Cell Reprogramming. | Suzuki YJ et al. | — | 2019 | → |
| A Revolution in Reprogramming: Small Molecules. | Zhou J et al. | — | 2019 | → |
| Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal. | Di Bella DJ et al. | — | 2019 | → |
| A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons. | Sridharan B et al. | — | 2019 | → |
| Attenuation of PRRX2 and HEY2 enables efficient conversion of adult human skin fibroblasts to neurons. | Li H et al. | — | 2019 | → |
| Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology. | Fenske P et al. | — | 2019 | → |
| bHLH transcription factors in neural development, disease, and reprogramming. | Dennis DJ et al. | — | 2019 | → |
| BRN2, a POUerful driver of melanoma phenotype switching and metastasis. | Fane ME et al. | — | 2019 | → |
| Cell-based therapy for Parkinson's disease: A journey through decades toward the light side of the Force. | Parmar M et al. | — | 2019 | → |
| Cell Reprogramming: The Many Roads to Success. | Aydin B et al. | — | 2019 | → |
| Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons. | Herdy J et al. | — | 2019 | → |
| Chemotherapy-Induced Neuropathy and Drug Discovery Platform Using Human Sensory Neurons Converted Directly from Adult Peripheral Blood. | Vojnits K et al. | — | 2019 | → |
| Combination of Chemical and Neurotrophin Stimulation Modulates Neurotransmitter Receptor Expression and Activity in Transdifferentiating Human Adipose Stromal Cells. | Nery AA et al. | — | 2019 | → |
| Comparison between curcumin and all-trans retinoic acid in the osteogenic differentiation of mouse bone marrow mesenchymal stem cells. | Ahmed MF et al. | — | 2019 | → |
| Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics. | Fantuzzo JA et al. | — | 2019 | → |
| Computational Analysis of Altering Cell Fate. | Abdallah HM et al. | — | 2019 | → |
| Connectomics of Morphogenetically Engineered Neurons as a Predictor of Functional Integration in the Ischemic Brain. | Sandvig A et al. | — | 2019 | → |
| Contribution of induced pluripotent stem cell technologies to the understanding of cellular phenotypes in schizophrenia. | Balan S et al. | — | 2019 | → |
| Conversion of Astrocytes and Fibroblasts into Functional Noradrenergic Neurons. | Li S et al. | — | 2019 | → |
| Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors. | Cheng Z et al. | — | 2019 | → |
| Conversion of human and mouse fibroblasts into lung-like epithelial cells. | Wong AP et al. | — | 2019 | → |
| CRISPR-activation-based screen reveals neuronal fate promotion by polycomb repressive complex 2 during direct reprogramming. | Wolfram T et al. | — | 2019 | → |
| DC3 is a method for deconvolution and coupled clustering from bulk and single-cell genomics data. | Zeng W et al. | — | 2019 | → |
| Decoding cell signalling and regulation of oligodendrocyte differentiation. | Santos AK et al. | — | 2019 | → |
| Deconstructing age reprogramming. | Singh PB et al. | — | 2019 | → |
| Differentiation of neural rosettes from human pluripotent stem cells in vitro is sequentially regulated on a molecular level and accomplished by the mechanism reminiscent of secondary neurulation. | Fedorova V et al. | — | 2019 | → |
| Direct cell reprogramming for tissue engineering and regenerative medicine. | Grath A et al. | — | 2019 | → |
| Direct conversion of adult human skin fibroblasts into functional Schwann cells that achieve robust recovery of the severed peripheral nerve in rats. | Kitada M et al. | — | 2019 | → |
| Direct conversion of fibroblasts to osteoblasts as a novel strategy for bone regeneration in elderly individuals. | Chang Y et al. | — | 2019 | → |
| Direct Conversion of Human Urine Cells to Neurons by Small Molecules. | Xu G et al. | — | 2019 | → |
| Direct conversion of mouse embryonic fibroblast to osteoblast cells using hLMP-3 with Yamanaka factors. | Ahmed MF et al. | — | 2019 | → |
| Directed Differentiation of Pluripotent Stem Cells by Transcription Factors. | Oh Y et al. | — | 2019 | → |
| Direct neuronal reprogramming of olfactory ensheathing cells for CNS repair. | Sun X et al. | — | 2019 | → |
| Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors. | Colasante G et al. | — | 2019 | → |
| Direct reprogramming into interneurons: potential for brain repair. | Pereira M et al. | — | 2019 | → |
| Direct Reprogramming to Human Induced Neuronal Progenitors from Fibroblasts of Familial and Sporadic Parkinson's Disease Patients. | Lee M et al. | — | 2019 | → |
| Dual modulation of neuron-specific microRNAs and the REST complex promotes functional maturation of human adult induced neurons. | Birtele M et al. | — | 2019 | → |
| Electrical stimulation induces direct reprogramming of human dermal fibroblasts into hyaline chondrogenic cells. | Lee GS et al. | — | 2019 | → |
| Emerging Technologies for Tissue Engineering: From Gene Editing to Personalized Medicine. | Armstrong JPK et al. | — | 2019 | → |
| Engineering Precision Medicine. | Sun W et al. | — | 2019 | → |
| ETV2/ER71 Transcription Factor as a Therapeutic Vehicle for Cardiovascular Disease. | Lee DH et al. | — | 2019 | → |
| Evolving principles underlying neural lineage conversion and their relevance for biomedical translation. | Flitsch LJ et al. | — | 2019 | → |
| Experimental and Computational Approaches to Direct Cell Reprogramming: Recent Advancement and Future Challenges. | Gam R et al. | — | 2019 | → |
| From Schizophrenia Genetics to Disease Biology: Harnessing New Concepts and Technologies. | Duan J et al. | — | 2019 | → |
| Generation of Genetically Stable Human Direct-Conversion-Derived Neural Stem Cells Using Quantity Control of Proto-oncogene Expression. | Daekee K et al. | — | 2019 | → |
| Genetic conversion of proliferative astroglia into neurons after cerebral ischemia: a new therapeutic tool for the aged brain? | Popa-Wagner A et al. | — | 2019 | → |
| Genome-wide analysis of RNA and protein localization and local translation in mESC-derived neurons. | Ludwik KA et al. | — | 2019 | → |
| Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons. | Luo C et al. | — | 2019 | → |
| Glycolytic Switch Is Required for Transdifferentiation to Endothelial Lineage. | Lai L et al. | — | 2019 | → |
| Hand2 Selectively Reorganizes Chromatin Accessibility to Induce Pacemaker-like Transcriptional Reprogramming. | Fernandez-Perez A et al. | — | 2019 | → |
| Harnessing cellular aging in human stem cell models of amyotrophic lateral sclerosis. | Ziff OJ et al. | — | 2019 | → |
| Helix-loop-helix proteins and the advent of cellular diversity: 30 years of discovery. | Murre C | — | 2019 | → |
| Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. | Mahmoudi S et al. | — | 2019 | → |
| Human Dental Pulp Stem Cells and Gingival Mesenchymal Stem Cells Display Action Potential Capacity In Vitro after Neuronogenic Differentiation. | Li D et al. | — | 2019 | → |
| Human Stem Cell-Derived Models: Lessons for Autoimmune Diseases of the Nervous System. | Harschnitz O | — | 2019 | → |
| Hybrid Nanofiber Scaffold-Based Direct Conversion of Neural Precursor Cells/Dopamine Neurons. | Lim MS et al. | — | 2019 | → |
| Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells. | Thier MC et al. | — | 2019 | → |
| Impelling force and current challenges by chemicals in somatic cell reprogramming and expansion beyond hepatocytes. | Ge JY et al. | — | 2019 | → |
| Induced pluripotent stem cell-based modeling of mutant LRRK2-associated Parkinson's disease. | Weykopf B et al. | — | 2019 | → |
| Inferring Regulatory Programs Governing Region Specificity of Neuroepithelial Stem Cells during Early Hindbrain and Spinal Cord Development. | Chasman D et al. | — | 2019 | → |
| Inhibition of Glioma Development by ASCL1-Mediated Direct Neuronal Reprogramming. | Cheng X et al. | — | 2019 | → |
| Intestinal Neurod1 expression impairs paneth cell differentiation and promotes enteroendocrine lineage specification. | Li HJ et al. | — | 2019 | → |
| In Vitro Functional Characterization of Human Neurons and Astrocytes Using Calcium Imaging and Electrophysiology. | Hansen MG et al. | — | 2019 | → |
| In vivo direct reprogramming of glial linage to mature neurons after cerebral ischemia. | Yamashita T et al. | — | 2019 | → |
| Live-Imaging Readouts and Cell Models for Phenotypic Profiling of Mitochondrial Function. | Iannetti EF et al. | — | 2019 | → |
| Liver to Pancreas Transdifferentiation. | Meivar-Levy I et al. | — | 2019 | → |
| Magnetic Control of Axon Navigation in Reprogrammed Neurons. | Jin Y et al. | — | 2019 | → |
| Metastable Reprogramming State of Single Transcription Factor-Derived Induced Hepatocyte-Like Cells. | Hwang SI et al. | — | 2019 | → |
| Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. | Babos KN et al. | — | 2019 | → |
| Modelling mitochondrial dysfunction in Alzheimer's disease using human induced pluripotent stem cells. | Hawkins KE et al. | — | 2019 | → |
| Molecular Interaction Networks to Select Factors for Cell Conversion. | Ouyang JF et al. | — | 2019 | → |
| mRNA-Driven Generation of Transgene-Free Neural Stem Cells from Human Urine-Derived Cells. | Kang PJ et al. | — | 2019 | → |
| Multiplication of the SNCA locus exacerbates neuronal nuclear aging. | Tagliafierro L et al. | — | 2019 | → |
| Multi-site phosphorylation controls the neurogenic and myogenic activity of E47. | Hardwick LJA et al. | — | 2019 | → |
| Neural stem cell therapies and hypoxic-ischemic brain injury. | Huang L et al. | — | 2019 | → |
| Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. | Patzke C et al. | — | 2019 | → |
| Next-generation disease modeling with direct conversion: a new path to old neurons. | Traxler L et al. | — | 2019 | → |
| Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains. | Lei W et al. | — | 2019 | → |
| Novel Direct Conversion of Microglia to Neurons. | Trudler D et al. | — | 2019 | → |
| Novel insights into cell cycle regulation of cell fate determination. | Gao SW et al. | — | 2019 | → |
| Novel Tools towards Magnetic Guidance of Neurite Growth: (I) Guidance of Magnetic Nanoparticles into Neurite Extensions of Induced Human Neurons and In Vitro Functionalization with RAS Regulating Proteins. | Schöneborn H et al. | — | 2019 | → |
| OCT4 and PAX6 determine the dual function of SOX2 in human ESCs as a key pluripotent or neural factor. | Zhang S et al. | — | 2019 | → |
| ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility. | van der Raadt J et al. | — | 2019 | → |
| Organs to Cells and Cells to Organoids: The Evolution of <i>in vitro</i> Central Nervous System Modelling. | Pacitti D et al. | — | 2019 | → |
| Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons. | Schafer ST et al. | — | 2019 | → |
| Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance. | Gupta PB et al. | — | 2019 | → |
| Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion. | Matsuda T et al. | — | 2019 | → |
| Plasmid-based generation of neural cells from human fibroblasts using non-integrating episomal vectors. | Dai SB et al. | — | 2019 | → |
| Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2. | Malik V et al. | — | 2019 | → |
| Potential application of cell reprogramming techniques for cancer research. | Saito S et al. | — | 2019 | → |
| Precision medicine in pantothenate kinase-associated neurodegeneration. | Alvarez-Cordoba M et al. | — | 2019 | → |
| Proteomics in the World of Induced Pluripotent Stem Cells. | Lindoso RS et al. | — | 2019 | → |
| Radial Glia in Echinoderms. | Mashanov V et al. | — | 2019 | → |
| Rapid and Efficient Conversion of Human Fibroblasts into Functional Neurons by Small Molecules. | Yang Y et al. | — | 2019 | → |
| Recapitulating kidney development: Progress and challenges. | Little MH et al. | — | 2019 | → |
| SATB2 and NGR1: potential upstream regulatory factors in uterine leiomyomas. | Sato S et al. | — | 2019 | → |
| Seeking fate-CRISPRa screens reveal new neural lineage and reprogramming factors. | Baumann V et al. | — | 2019 | → |
| Silencing the alternative. | Sivaramakrishnan P et al. | — | 2019 | → |
| Single-cell multimodal transcriptomics to study neuronal diversity in human stem cell-derived brain tissue and organoid models. | van den Hurk M et al. | — | 2019 | → |
| Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming. | Francesconi M et al. | — | 2019 | → |
| Somatic cell reprogramming as a tool for neurodegenerative diseases. | Ebrahimi A et al. | — | 2019 | → |
| Somatic MIWI2 Hinders Direct Lineage Reprogramming From Fibroblast to Hepatocyte. | Shi X et al. | — | 2019 | → |
| Stemming retinal regeneration with pluripotent stem cells. | Jin ZB et al. | — | 2019 | → |
| Structural Features of Transcription Factors Associating with Nucleosome Binding. | Fernandez Garcia M et al. | — | 2019 | → |
| Take the shortcut - direct conversion of somatic cells into induced neural stem cells and their biomedical applications. | Erharter A et al. | — | 2019 | → |
| The Chromatin Environment Around Interneuron Genes in Oligodendrocyte Precursor Cells and Their Potential for Interneuron Reprograming. | Boshans LL et al. | — | 2019 | → |
| The novel lncRNA <i>lnc-NR2F1</i> is pro-neurogenic and mutated in human neurodevelopmental disorders. | Ang CE et al. | — | 2019 | → |
| The pleiotropic transcriptional regulator COUP-TFI plays multiple roles in neural development and disease. | Bertacchi M et al. | — | 2019 | → |
| Tox4 modulates cell fate reprogramming. | Vanheer L et al. | — | 2019 | → |
| Transcription Factor-Directed Re-wiring of Chromatin Architecture for Somatic Cell Nuclear Reprogramming toward trans-Differentiation. | Dall'Agnese A et al. | — | 2019 | → |
| Transcription Factors That Govern Development and Disease: An Achilles Heel in Cancer. | Huilgol D et al. | — | 2019 | → |
| Understanding and Modulating Immunity With Cell Reprogramming. | Pires CF et al. | — | 2019 | → |
| Using Dental Pulp Stem Cells for Stroke Therapy. | Gancheva MR et al. | — | 2019 | → |
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | — | 2019 | → |
| Using transcription factors for direct reprogramming of neurons <i>in vitro</i>. | El Wazan L et al. | — | 2019 | → |
| Adult Neural Stem Cells: Basic Research and Production Strategies for Neurorestorative Therapy. | Samoilova EM et al. | — | 2018 | → |
| Adult Stem Cell-Based Strategies for Peripheral Nerve Regeneration. | De la Rosa MB et al. | — | 2018 | → |
| Advances in Functional Restoration of the Lacrimal Glands. | Hirayama M | — | 2018 | → |
| Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases. | Mertens J et al. | — | 2018 | → |
| Allele-Specific Biased Expression of the CNTN6 Gene in iPS Cell-Derived Neurons from a Patient with Intellectual Disability and 3p26.3 Microduplication Involving the CNTN6 Gene. | Gridina MM et al. | — | 2018 | → |
| Analysis of transcriptional activity by the Myt1 and Myt1l transcription factors. | Manukyan A et al. | — | 2018 | → |
| A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification. | Guo WF et al. | — | 2018 | → |
| Assessment of stem cell differentiation based on genome-wide expression profiles. | Godoy P et al. | — | 2018 | → |
| A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. | Sheng C et al. | — | 2018 | → |
| A systems mechanobiology model to predict cardiac reprogramming outcomes on different biomaterials. | Kong YP et al. | — | 2018 | → |
| Binding of HMGN proteins to cell specific enhancers stabilizes cell identity. | He B et al. | — | 2018 | → |
| Brief summary of the current protocols for generating intestinal organoids. | Miura S et al. | — | 2018 | → |
| Brn2 Alone Is Sufficient to Convert Astrocytes into Neural Progenitors and Neurons. | Zhu X et al. | — | 2018 | → |
| Cardiac Stem Cells in the Postnatal Heart: Lessons from Development. | Aguilar-Sanchez C et al. | — | 2018 | → |
| Cell cycle-dependent phosphorylation and regulation of cellular differentiation. | Hardwick LJA et al. | — | 2018 | → |
| Cell lineage tracing in the retina: Could material transfer distort conclusions? | Boudreau-Pinsonneault C et al. | — | 2018 | → |
| Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities. | Hébert JM et al. | — | 2018 | → |
| Cellular Models: HD Patient-Derived Pluripotent Stem Cells. | Geater C et al. | — | 2018 | → |
| Chemical compound-based direct reprogramming for future clinical applications. | Takeda Y et al. | — | 2018 | → |
| Chemical conversion of human lung fibroblasts into neuronal cells. | Wan XY et al. | — | 2018 | → |
| Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors. | Chai M et al. | — | 2018 | → |
| Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission. | Nehme R et al. | — | 2018 | → |
| Computational approaches for predicting key transcription factors in targeted cell reprogramming (Review). | Guerrero-Ramirez GI et al. | — | 2018 | → |
| Computer logic meets cell biology: how cell science is getting an upgrade. | Savage N | — | 2018 | → |
| Conversion of adult human fibroblasts into neural precursor cells using chemically modified mRNA. | Connor B et al. | — | 2018 | → |
| CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming. | Liu Y et al. | — | 2018 | → |
| Current and Future Trends in Adipose Stem Cell Differentiation into Neuroglia. | George S et al. | — | 2018 | → |
| Customized Brain Cells for Stroke Patients Using Pluripotent Stem Cells. | Kokaia Z et al. | — | 2018 | → |
| Direct Cardiac Reprogramming: Progress and Promise. | Engel JL et al. | — | 2018 | → |
| Direct Control of Stem Cell Behavior Using Biomaterials and Genetic Factors. | Yoon JK et al. | — | 2018 | → |
| Direct conversion of human fibroblasts into functional Leydig-like cells by <i>SF-1</i>, <i>GATA4</i> and <i>NGFI-B</i>. | Hou YP et al. | — | 2018 | → |
| Directing neuronal cell fate in vitro: Achievements and challenges. | Riemens RJM et al. | — | 2018 | → |
| Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program. | Karow M et al. | — | 2018 | → |
| Direct Reprograming to Regenerate Myocardium and Repair Its Pacemaker and Conduction System. | Adepu S et al. | — | 2018 | → |
| Direct Reprogramming of Adult Human Somatic Stem Cells Into Functional Neurons Using <i>Sox2, Ascl1</i>, and <i>Neurog2</i>. | Araújo JAM et al. | — | 2018 | → |
| Direct Reprogramming of Glioblastoma Cells into Neurons Using Small Molecules. | Lee C et al. | — | 2018 | → |
| Diverse reprogramming codes for neuronal identity. | Tsunemoto R et al. | — | 2018 | → |
| Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming. | Malik V et al. | — | 2018 | → |
| Elixir of Life: Thwarting Aging With Regenerative Reprogramming. | Beyret E et al. | — | 2018 | → |
| Engineered Neurons May Generate Future Therapy for Neurological Disease. | Brusko GD et al. | — | 2018 | → |
| Engineering new neurons: in vivo reprogramming in mammalian brain and spinal cord. | Wang LL et al. | — | 2018 | → |
| Establishment and Identification of a CiPSC Lineage Reprogrammed from FSP-tdTomato Mouse Embryonic Fibroblasts (MEFs). | Chen R et al. | — | 2018 | → |
| Establishment of stably expandable induced myogenic stem cells by four transcription factors. | Lee EJ et al. | — | 2018 | → |
| FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. | Kolundzic E et al. | — | 2018 | → |
| Fibroblasts as maestros orchestrating tissue regeneration. | Costa-Almeida R et al. | — | 2018 | → |
| Forging our understanding of lncRNAs in the brain. | Andersen RE et al. | — | 2018 | → |
| Functional cargo delivery into mouse and human fibroblasts using a versatile microfluidic device. | Lam KH et al. | — | 2018 | → |
| Generation of Functional Dopaminergic Neurons from Reprogramming Fibroblasts by Nonviral-based Mesoporous Silica Nanoparticles. | Chang JH et al. | — | 2018 | → |
| Genomic analysis of transcriptional networks directing progression of cell states during MGE development. | Sandberg M et al. | — | 2018 | → |
| Groucho related gene 5 (GRG5) is involved in embryonic and neural stem cell state decisions. | Chanoumidou K et al. | — | 2018 | → |
| High-throughput drug screens for amyotrophic lateral sclerosis drug discovery. | McGown A et al. | — | 2018 | → |
| hsa-let-7c miRNA Regulates Synaptic and Neuronal Function in Human Neurons. | McGowan H et al. | — | 2018 | → |
| Human cellular models of medium spiny neuron development and Huntington disease. | Golas MM | — | 2018 | → |
| Human Cortical Neuron Generation Using Cell Reprogramming: A Review of Recent Advances. | McCaughey-Chapman A et al. | — | 2018 | → |
| Human dental stem cell derived transgene-free iPSCs generate functional neurons via embryoid body-mediated and direct induction methods. | El Ayachi I et al. | — | 2018 | → |
| Human Induced Pluripotent Stem Cell Production and Expansion from Blood using a Non-Integrating Viral Reprogramming Vector. | Sharma A et al. | — | 2018 | → |
| Human neurons to model aging: A dish best served old. | Böhnke L et al. | — | 2018 | → |
| Human stem cell modeling in neurofibromatosis type 1 (NF1). | Wegscheid ML et al. | — | 2018 | → |
| Huntington modeling improves with age. | Mattis VB et al. | — | 2018 | → |
| <i>In vitro</i> Models for Seizure-Liability Testing Using Induced Pluripotent Stem Cells. | Grainger AI et al. | — | 2018 | → |
| Inducing hair follicle neogenesis with secreted proteins enriched in embryonic skin. | Fan SM et al. | — | 2018 | → |
| <i>N</i>-Glycosylation Regulates the Trafficking and Surface Mobility of GluN3A-Containing NMDA Receptors. | Skrenkova K et al. | — | 2018 | → |
| Intrinsic DNA binding properties demonstrated for lineage-specifying basic helix-loop-helix transcription factors. | Casey BH et al. | — | 2018 | → |
| In vitro study of the effects of reprogramming neonatal rat fibroblasts transfected with TBX18 on spontaneous beating in neonatal rat cardiomyocytes. | Quan D et al. | — | 2018 | → |
| In Vivo Evaluation of PAX6 Overexpression and NMDA Cytotoxicity to Stimulate Proliferation in the Mouse Retina. | Ranaei Pirmardan E et al. | — | 2018 | → |
| iPS cells in the study of PD molecular pathogenesis. | Cobb MM et al. | — | 2018 | → |
| KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes. | Barbagiovanni G et al. | — | 2018 | → |
| Lineage Plasticity in Cancer Progression and Treatment. | Le Magnen C et al. | — | 2018 | → |
| Materials for Neural Differentiation, Trans-Differentiation, and Modeling of Neurological Disease. | Gong L et al. | — | 2018 | → |
| Mechanisms of Cortical Differentiation. | Adnani L et al. | — | 2018 | → |
| Mechanistic Insights Into MicroRNA-Induced Neuronal Reprogramming of Human Adult Fibroblasts. | Lu YL et al. | — | 2018 | → |
| Metabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs). | Lagies S et al. | — | 2018 | → |
| MicroRNA-Directed Neuronal Reprogramming as a Therapeutic Strategy for Neurological Diseases. | Faravelli I et al. | — | 2018 | → |
| miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation. | De Gregorio R et al. | — | 2018 | → |
| Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells. | LaMarca EA et al. | — | 2018 | → |
| More than one way to induce a neuron. | Lim L et al. | — | 2018 | → |
| Msx2 Supports Epidermal Competency during Wound-Induced Hair Follicle Neogenesis. | Hughes MW et al. | — | 2018 | → |
| Multigene delivery in mammalian cells: Recent advances and applications. | Mansouri M et al. | — | 2018 | → |
| Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression. | Melhuish TA et al. | — | 2018 | → |
| Myt1l induced direct reprogramming of pericytes into cholinergic neurons. | Liang XG et al. | — | 2018 | → |
| Myt1L Promotes Differentiation of Oligodendrocyte Precursor Cells and is Necessary for Remyelination After Lysolecithin-Induced Demyelination. | Shi Y et al. | — | 2018 | → |
| Natural and forced neurogenesis: similar and yet different? | Falk S et al. | — | 2018 | → |
| Neural stem cell differentiation into mature neurons: Mechanisms of regulation and biotechnological applications. | Vieira MS et al. | — | 2018 | → |
| Neural stem cell therapy aiming at better functional recovery after spinal cord injury. | Zhu Y et al. | — | 2018 | → |
| Neural stem cell therapy-Brief review. | Grochowski C et al. | — | 2018 | → |
| Nonintegrating Direct Conversion Using mRNA into Hepatocyte-Like Cells. | Yoon S et al. | — | 2018 | → |
| NTF3 Is a Novel Target Gene of the Transcription Factor POU3F2 and Is Required for Neuronal Differentiation. | Lin YJ et al. | — | 2018 | → |
| Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. | Brumbaugh J et al. | — | 2018 | → |
| On the Viability and Potential Value of Stem Cells for Repair and Treatment of Central Neurotrauma: Overview and Speculations. | Wu S et al. | — | 2018 | → |
| Open chromatin dynamics reveals stage-specific transcriptional networks in hiPSC-based neurodevelopmental model. | Zhang S et al. | — | 2018 | → |
| Optimization of Synthetic mRNA for Highly Efficient Translation and its Application in the Generation of Endothelial and Hematopoietic Cells from Human and Primate Pluripotent Stem Cells. | Suknuntha K et al. | — | 2018 | → |
| Overexpression of the proneural transcription factor ASCL1 in chronic lymphocytic leukemia with a t(12;14)(q23.2;q32.3). | Malli T et al. | — | 2018 | → |
| Parkinson's disease: what the model systems have taught us so far. | Ghatak S et al. | — | 2018 | → |
| Patient-Derived Induced Pluripotent Stem Cells and Organoids for Modeling Alpha Synuclein Propagation in Parkinson's Disease. | Koh YH et al. | — | 2018 | → |
| Patient-Derived iPSCs and iNs-Shedding New Light on the Cellular Etiology of Neurodegenerative Diseases. | Tang BL | — | 2018 | → |
| Peptide Nanofiber Substrates for Long-Term Culturing of Primary Neurons. | Martin AD et al. | — | 2018 | → |
| Pioneer Factors in Animals and Plants-Colonizing Chromatin for Gene Regulation. | Lai X et al. | — | 2018 | → |
| Pluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects. | Sonntag KC et al. | — | 2018 | → |
| Potentials of Cellular Reprogramming as a Novel Strategy for Neuroregeneration. | Fang L et al. | — | 2018 | → |
| POU3F2 participates in cognitive function and adult hippocampal neurogenesis via mammalian-characteristic amino acid repeats. | Hashizume K et al. | — | 2018 | → |
| Proteomic Analysis of Nucleus Pulposus Cell-derived Extracellular Matrix Niche and Its Effect on Phenotypic Alteration of Dermal Fibroblasts. | Yuan M et al. | — | 2018 | → |
| Recent Advances: Decoding Alzheimer's Disease With Stem Cells. | Fang Y et al. | — | 2018 | → |
| Recent Advances in the Genetics of Schizophrenia. | Avramopoulos D | — | 2018 | → |
| Repairing the Brain: Cell Replacement Using Stem Cell-Based Technologies. | Henchcliffe C et al. | — | 2018 | → |
| Representing Diversity in the Dish: Using Patient-Derived <i>in Vitro</i> Models to Recreate the Heterogeneity of Neurological Disease. | Ghaffari LT et al. | — | 2018 | → |
| Reprogramming Glia Into Neurons in the Peripheral Auditory System as a Solution for Sensorineural Hearing Loss: Lessons From the Central Nervous System. | Meas SJ et al. | — | 2018 | → |
| Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors. | Yuan J et al. | — | 2018 | → |
| Reprogramming of mouse fibroblasts into neural lineage cells using biomaterials. | Kantawong F et al. | — | 2018 | → |
| Reprogramming, oscillations and transdifferentiation in epigenetic landscapes. | Kaity B et al. | — | 2018 | → |
| Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters. | Grunseich C et al. | — | 2018 | → |
| Sendai virus based direct cardiac reprogramming: what lies ahead? | Engel JL et al. | — | 2018 | → |
| Shaping Gene Expression by Landscaping Chromatin Architecture: Lessons from a Master. | Sartorelli V et al. | — | 2018 | → |
| Single-cell genomics to guide human stem cell and tissue engineering. | Camp JG et al. | — | 2018 | → |
| Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiation. | Shang Z et al. | — | 2018 | → |
| SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States. | Cossec JC et al. | — | 2018 | → |
| Synthetic transcription factors for cell fate reprogramming. | Black JB et al. | — | 2018 | → |
| Targeting Alzheimer's disease with gene and cell therapies. | Loera-Valencia R et al. | — | 2018 | → |
| The causal relationship between epigenetic abnormality and cancer development: in vivo reprogramming and its future application. | Yamada Y et al. | — | 2018 | → |
| The complex simplicity of the brittle star nervous system. | Zueva O et al. | — | 2018 | → |
| The N terminus of Ascl1 underlies differing proneural activity of mouse and <i>Xenopus</i> Ascl1 proteins. | Hardwick LJA et al. | — | 2018 | → |
| The Paraventricular Nucleus of the Hypothalamus: Development, Function, and Human Diseases. | Qin C et al. | — | 2018 | → |
| The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. | Sun N et al. | — | 2018 | → |
| The Presence of Neural Stem Cells and Changes in Stem Cell-Like Activity With Age in Mouse Spiral Ganglion Cells In Vivo and In Vitro. | Moon BS et al. | — | 2018 | → |
| The proneural bHLH genes Mash1, Math3 and NeuroD are required for pituitary development | Ando M et al. | — | 2018 | → |
| Therapeutic effects of stem cells in rodent models of Huntington's disease: Review and electrophysiological findings. | Holley SM et al. | — | 2018 | → |
| The rise of three-dimensional human brain cultures. | Pașca SP | — | 2018 | → |
| The state of the art in stem cell biology and regenerative medicine: the end of the beginning. | Snyder EY | — | 2018 | → |
| The Wnt/β-catenin pathway determines the predisposition and efficiency of liver-to-pancreas reprogramming. | Cohen H et al. | — | 2018 | → |
| Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons. | Jin Y et al. | — | 2018 | → |
| Towards stem cell based therapies for Parkinson's disease. | Parmar M | — | 2018 | → |
| Transcription factor programming of human ES cells generates functional neurons expressing both upper and deep layer cortical markers. | Miskinyte G et al. | — | 2018 | → |
| Transdifferentiating Astrocytes Into Neurons Using ASCL1 Functionalized With a Novel Intracellular Protein Delivery Technology. | Robinson M et al. | — | 2018 | → |
| Transdifferentiation: a new promise for neurodegenerative diseases. | Mollinari C et al. | — | 2018 | → |
| Transdifferentiation of human adult peripheral blood T cells into neurons. | Tanabe K et al. | — | 2018 | → |
| Uncovering True Cellular Phenotypes: Using Induced Pluripotent Stem Cell-Derived Neurons to Study Early Insults in Neurodevelopmental Disorders. | Fink JJ et al. | — | 2018 | → |
| Understanding direct neuronal reprogramming-from pioneer factors to 3D chromatin. | Ninkovic J et al. | — | 2018 | → |
| Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. | Roh HC et al. | — | 2018 | → |
| A computational systems approach identifies synergistic specification genes that facilitate lineage conversion to prostate tissue. | Talos F et al. | — | 2017 | → |
| A deterministic method for estimating free energy genetic network landscapes with applications to cell commitment and reprogramming paths. | Olariu V et al. | — | 2017 | → |
| Advanced Gene Manipulation Methods for Stem Cell Theranostics. | Rathnam C et al. | — | 2017 | → |
| A mouse tissue transcription factor atlas. | Zhou Q et al. | — | 2017 | → |
| Animal and cellular models of familial dysautonomia. | Lefcort F et al. | — | 2017 | → |
| Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease. | Powell SK et al. | — | 2017 | → |
| Applications of Tissue Engineering in Joint Arthroplasty: Current Concepts Update. | Zeineddine HA et al. | — | 2017 | → |
| ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells. | Park NI et al. | — | 2017 | → |
| Associations of the Intellectual Disability Gene MYT1L with Helix-Loop-Helix Gene Expression, Hippocampus Volume and Hippocampus Activation During Memory Retrieval. | Kepa A et al. | — | 2017 | → |
| Cell fate modification toward the hepatic lineage by extrinsic factors. | Kawamata M et al. | — | 2017 | → |
| Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain. | López-León M et al. | — | 2017 | → |
| Cell Therapy for Parkinson's Disease. | Yasuhara T et al. | — | 2017 | → |
| Cellular reprogramming dynamics follow a simple 1D reaction coordinate. | Pusuluri ST et al. | — | 2017 | → |
| Cellular reprogramming technology for dissecting cancer epigenome in vivo. | Ito K et al. | — | 2017 | → |
| Chemical reprogramming and transdifferentiation. | Xie X et al. | — | 2017 | → |
| Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage. | Cao S et al. | — | 2017 | → |
| Cochlear Implants Meet Regenerative Biology: State of the Science and Future Research Directions. | Dabdoub A et al. | — | 2017 | → |
| Comparative Analysis of Non-viral Transfection Methods in Mouse Embryonic Fibroblast Cells. | Lee M et al. | — | 2017 | → |
| Comparative gene expression study and pathway analysis of the human iris- and the retinal pigment epithelium. | Bennis A et al. | — | 2017 | → |
| Comparison of Reprogramming Methods for Generation of Induced-Oligodendrocyte Precursor Cells. | Lee EH et al. | — | 2017 | → |
| Concise Review: Induced Pluripotent Stem Cell Models for Neuropsychiatric Diseases. | Adegbola A et al. | — | 2017 | → |
| Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. | Ruetz T et al. | — | 2017 | → |
| Controlled re-activation of epigenetically silenced Tet promoter-driven transgene expression by targeted demethylation. | Gödecke N et al. | — | 2017 | → |
| CRISPR Transcriptional Activation Analysis Unmasks an Occult γ-Secretase Processivity Defect in Familial Alzheimer's Disease Skin Fibroblasts. | Inoue K et al. | — | 2017 | → |
| Cyclin-Dependent Kinase-Dependent Phosphorylation of Sox2 at Serine 39 Regulates Neurogenesis. | Lim S et al. | — | 2017 | → |
| DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells. | Harterink M et al. | — | 2017 | → |
| Direct conversion of human fibroblasts to functional excitatory cortical neurons integrating into human neural networks. | Miskinyte G et al. | — | 2017 | → |
| Direct Conversion of Human Umbilical Cord Blood into Induced Neural Stem Cells with SOX2 and HMGA2. | Kim JJ et al. | — | 2017 | → |
| Direct induction of functional neuronal cells from fibroblast-like cells derived from adult human retina. | Hao L et al. | — | 2017 | → |
| Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus. | Avaliani N et al. | — | 2017 | → |
| Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success. | Gascón S et al. | — | 2017 | → |
| Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned? | Drouin-Ouellet J et al. | — | 2017 | → |
| Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State. | Li X et al. | — | 2017 | → |
| Direct reprogramming of mouse fibroblasts into neural cells via Porphyra yezoensis polysaccharide based high efficient gene co-delivery. | Yu Q et al. | — | 2017 | → |
| Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons. | Pereira M et al. | — | 2017 | → |
| Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons. | Tang Y et al. | — | 2017 | → |
| DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells. | Sanosaka T et al. | — | 2017 | → |
| Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study. | Sagata N et al. | — | 2017 | → |
| Editorial overview: Cell reprogramming: Carpe diem. | Esteban MA et al. | — | 2017 | → |
| Electromagnetized gold nanoparticles mediate direct lineage reprogramming into induced dopamine neurons in vivo for Parkinson's disease therapy. | Yoo J et al. | — | 2017 | → |
| Engineering cell identity: establishing new gene regulatory and chromatin landscapes. | Guo C et al. | — | 2017 | → |
| Engineering kidney cells: reprogramming and directed differentiation to renal tissues. | Kaminski MM et al. | — | 2017 | → |
| Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury. | Lisi V et al. | — | 2017 | → |
| Evolution of microRNA in primates. | McCreight JC et al. | — | 2017 | → |
| Finding MyoD and lessons learned along the way. | Lassar AB | — | 2017 | → |
| Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming. | Miura S et al. | — | 2017 | → |
| Generation of multipotent induced cardiac progenitor cells from mouse fibroblasts and potency testing in ex vivo mouse embryos. | Lalit PA et al. | — | 2017 | → |
| Generation of patient specific human neural stem cells from Niemann-Pick disease type C patient-derived fibroblasts. | Sung EA et al. | — | 2017 | → |
| Generation of pure GABAergic neurons by transcription factor programming. | Yang N et al. | — | 2017 | → |
| Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. | Glasgow SM et al. | — | 2017 | → |
| Induced neural stem cells as a means of treatment in Huntington's disease. | Choi KA et al. | — | 2017 | → |
| Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease. | Jiménez-Moreno N et al. | — | 2017 | → |
| Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model. | Rivetti di Val Cervo P et al. | — | 2017 | → |
| <i>Neurog2</i> and <i>Ascl1</i> together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex. | Dennis DJ et al. | — | 2017 | → |
| iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer's Disease. | Kondo T et al. | — | 2017 | → |
| KDM3A-mediated demethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis. | Lin H et al. | — | 2017 | → |
| Lineage conversion of mouse fibroblasts to pancreatic α-cells. | Liu T et al. | — | 2017 | → |
| Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes. | Chouchane M et al. | — | 2017 | → |
| MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. | Li X et al. | — | 2017 | → |
| Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres. | Iki T et al. | — | 2017 | → |
| Modelling APOE ɛ3/4 allele-associated sporadic Alzheimer's disease in an induced neuron. | Kim H et al. | — | 2017 | → |
| Mouse embryonic stem cells can differentiate via multiple paths to the same state. | Briggs JA et al. | — | 2017 | → |
| MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus. | Blanchet P et al. | — | 2017 | → |
| Neural differentiation of fibroblasts induced by intracellular co-delivery of Ascl1, Brn2 and FoxA1 via a non-viral vector of cationic polysaccharide. | Yu Q et al. | — | 2017 | → |
| Neuronal replacement therapy: previous achievements and challenges ahead. | Grade S et al. | — | 2017 | → |
| New Advances and Challenges of Targeting Cancer Stem Cells. | Dashzeveg NK et al. | — | 2017 | → |
| New neurons in adult brain: distribution, molecular mechanisms and therapies. | Pino A et al. | — | 2017 | → |
| Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation. | Roese-Koerner B et al. | — | 2017 | → |
| Old and new challenges in Parkinson's disease therapeutics. | Pires AO et al. | — | 2017 | → |
| Operating principles of tristable circuits regulating cellular differentiation. | Jia D et al. | — | 2017 | → |
| Paying the Toll in Nuclear Reprogramming. | Liu C et al. | — | 2017 | → |
| Pluripotent stem cell-derived neurons for transplantation in Huntington's disease. | Li M et al. | — | 2017 | → |
| Programming cells for cardiac repair. | Romagnuolo R et al. | — | 2017 | → |
| Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons. | Wapinski OL et al. | — | 2017 | → |
| Ready, Set…Poised!: Polycomb target genes are bound by poised RNA polymerase II throughout differentiation. | Rada-Iglesias A | — | 2017 | → |
| Regenerating the human heart: direct reprogramming strategies and their current limitations. | Ghiroldi A et al. | — | 2017 | → |
| Regulation of cAMP and GSK3 signaling pathways contributes to the neuronal conversion of glioma. | Oh J et al. | — | 2017 | → |
| Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries. | Blanchard JW et al. | — | 2017 | → |
| Reprogramming of Dermal Fibroblasts into Osteo-Chondrogenic Cells with Elevated Osteogenic Potency by Defined Transcription Factors. | Wang Y et al. | — | 2017 | → |
| REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways. | Drouin-Ouellet J et al. | — | 2017 | → |
| Sensitive and long-term monitoring of intracellular microRNAs using a non-integrating cytoplasmic RNA vector. | Sano M et al. | — | 2017 | → |
| Sequential EMT-MET induces neuronal conversion through Sox2. | He S et al. | — | 2017 | → |
| Simple Maturation of Direct-Converted Hepatocytes Derived from Fibroblasts. | Cho YD et al. | — | 2017 | → |
| Single-Base Resolution Mapping of 5-Hydroxymethylcytosine Modifications in Hippocampus of Alzheimer's Disease Subjects. | Ellison EM et al. | — | 2017 | → |
| Single cell qPCR reveals that additional HAND2 and microRNA-1 facilitate the early reprogramming progress of seven-factor-induced human myocytes. | Bektik E et al. | — | 2017 | → |
| Small molecules for reprogramming and transdifferentiation. | Qin H et al. | — | 2017 | → |
| Stem cells: from biomedical research towards clinical applications. | Zenke M | — | 2017 | → |
| Systematic comparison of 2A peptides for cloning multi-genes in a polycistronic vector. | Liu Z et al. | — | 2017 | → |
| The doublesex-related Dmrta2 safeguards neural progenitor maintenance involving transcriptional regulation of Hes1. | Young FI et al. | — | 2017 | → |
| The formation of the light-sensing compartment of cone photoreceptors coincides with a transcriptional switch. | Daum JM et al. | — | 2017 | → |
| The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening. | Gonzalez DM et al. | — | 2017 | → |
| The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells. | Cortés D et al. | — | 2017 | → |
| The novel tool of cell reprogramming for applications in molecular medicine. | Mall M et al. | — | 2017 | → |
| The Potential of Targeting Brain Pathology with Ascl1/Mash1. | Tang BL | — | 2017 | → |
| The Role of NMDA Receptors in Neural Stem Cell Proliferation and Differentiation. | Chakraborty A et al. | — | 2017 | → |
| The zinc finger E-box-binding homeobox 1 (<i>Zeb1</i>) promotes the conversion of mouse fibroblasts into functional neurons. | Yan L et al. | — | 2017 | → |
| Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue. | Gallego-Perez D et al. | — | 2017 | → |
| Towards understanding transcriptional networks in cellular reprogramming. | Firas J et al. | — | 2017 | → |
| Transdifferentiation and reprogramming: Overview of the processes, their similarities and differences. | Cieślar-Pobuda A et al. | — | 2017 | → |
| Transdifferentiation of brain-derived neurotrophic factor (BDNF)-secreting mesenchymal stem cells significantly enhance BDNF secretion and Schwann cell marker proteins. | Bierlein De la Rosa M et al. | — | 2017 | → |
| Unraveling the biology of bipolar disorder using induced pluripotent stem-derived neurons. | Miller ND et al. | — | 2017 | → |
| μNeurocircuitry: Establishing <i>in vitro</i> models of neurocircuits with human neurons. | Fantuzzo JA et al. | — | 2017 | → |