Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator.
paper
Cited
Public
- Authors
- Bowden, Jack; Davey Smith, George; Haycock, Philip C; Burgess, Stephen
- Year
- 2016
- Journal
- Genetic epidemiology
- PMID
- 27061298
- DOI
- 10.1002/gepi.21965
- PMCID
- PMC4849733
Developments in genome-wide association studies and the increasing availability of summary genetic association data have made application of Mendelian randomization relatively straightforward. However, obtaining reliable results from a Mendelian randomization investigation remains problematic, as the conventional inverse-variance weighted method only gives consistent estimates if all of the genetic variants in the analysis are valid instrumental variables. We present a novel weighted median estimator for combining data on multiple genetic variants into a single causal estimate. This estimator is consistent even when up to 50% of the information comes from invalid instrumental variables. In a simulation analysis, it is shown to have better finite-sample Type 1 error rates than the inverse-variance weighted method, and is complementary to the recently proposed MR-Egger (Mendelian randomization-Egger) regression method. In analyses of the causal effects of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol on coronary artery disease risk, the inverse-variance weighted method suggests a causal effect of both lipid fractions, whereas the weighted median and MR-Egger regression methods suggest a null effect of high-density lipoprotein cholesterol that corresponds with the experimental evidence. Both median-based and MR-Egger regression methods should be considered as sensitivity analyses for Mendelian randomization investigations with multiple genetic variants.
Illustrative diagram representing the hypothesized relationships between genetic variant Gj, exposure X, disease Y, and confounders U when Gj is a valid instrumental variable (IV). Crosses indicate violations of assumptions IV2 and IV3 that potentially lead to invalid inferences from conventional methods.
Fictional example of a Mendelian randomization analysis with 10 genetic variants–six valid instrumental variables (hollow circles) and four invalid instrumental variables (solid circles) for finite sample size (left) and infinite sample size (right) showing IVW (solid line) and simple median (dashed line) estimates compared with the true causal effect (dotted line). The ratio estimate for each genetic variant is the gradient of the line connecting the relevant datapoint for that variant to the origin; the simple median estimate is the median of these ratio estimates.
Empirical distribution functions of ordered ratio instrumental variable estimates (β^j) used for calculation of the simple median estimate (black) and two weighted median estimates (shown in red and blue) using the weights given in Table 1.
Scatter plots of genetic associations with the outcome (coronary artery disease risk, CAD) against genetic associations with the exposure (low‐density lipoprotein cholesterol, LDL‐c; high‐density lipoprotein cholesterol, HDL‐c; triglycerides). Left side: all genetic variants, right side: genetic variants having primary association with the target exposure. Solid line represents IVW estimate, dashed line represents weighted median estimate, and dotted line represents MR‐Egger estimate.
1–20 of 45
Next →
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
| Citation | PMID | DOI | Status |
|---|---|---|---|
| Bochud M , Chiolero A , Elston R , Paccaud F . 2008 A cautionary note on the use of Mendelian randomization to infer causation in observational epidemiology. Int J Epidemiol 37(2):414–416.1788141010.1093/ije/dym186 | — | — | — |
| Bowden J , Davey Smith G , Burgess S . 2015 Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 44(2):512–525.2605025310.1093/ije/dyv080PMC4469799 | — | — | — |
| Bowden J , Thompson J , Burton P . 2006 Using pseudo‐data to correct for publication bias in meta‐analysis. Stat Med 25: 3798–3813.1638241810.1002/sim.2487 | — | — | — |
| Burgess S , Butterworth A , Thompson S . 2013 Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 37(7):658–665.2411480210.1002/gepi.21758PMC4377079 | — | — | — |
| Burgess S , Dudbridge F , Thompson SG . 2015a Re: “multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects.” Am J Epidemiol 181(4):290–291.2566008110.1093/aje/kwv017 | — | — | — |
| Burgess S , Scott R , Timpson N , Davey Smith G , Thompson S , EPIC‐InterAct Consortium . 2015b Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol 30(7):543–552.2577375010.1007/s10654-015-0011-zPMC4516908 | — | — | — |
| Burgess S , Thompson S , CRP CHD Genetics Collaboration . 2011 Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol 40(3):755–764.2141499910.1093/ije/dyr036 | — | — | — |
| Burgess S , Thompson SG . 2015 Mendelian Randomization: Methods for Using Genetic Variants in Causal Estimation. Chapman & Hall, Boca Raton, FL, USA. | — | — | — |
| CARDIoGRAMplusC4D Consortium . 2013 Large‐scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 45(1):25–33.2320212510.1038/ng.2480PMC3679547 | — | — | — |
| Cheung B , Lauder I , Lau C , Kumana C . 2004 Meta‐analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes. Br J Clin Pharmacol 57(5):640–651.1508981810.1111/j.1365-2125.2003.02060.xPMC1884492 | — | — | — |
| Davey Smith G , Ebrahim S . 2003 “Mendelian randomization”: can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 32(1):1–22.1268999810.1093/ije/dyg070 | — | — | — |
| Davey Smith G , Ebrahim S . 2004 Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 33(1):30–42.1507514310.1093/ije/dyh132 | — | — | — |
| Davey Smith G , Ebrahim S . 2005 What can Mendelian randomisation tell us about modifiable behavioural and environmental exposures? Br Med J 330(7499):1076–1079.1587940010.1136/bmj.330.7499.1076PMC557238 | — | — | — |
| Davey Smith G , Hemani G . 2014 Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet 23(R1):R89–R98.2506437310.1093/hmg/ddu328PMC4170722 | — | — | — |
| Di Angelantonio E , Sarwar N , Perry P , Kaptoge S , Ray KK , Thompson A , Wood AM , Lewington S , Sattar N , Packard CJ and others. 2009 Major lipids, apolipoproteins, and risk of vascular disease. J Am Med Assoc 302(18):1993–2000.10.1001/jama.2009.1619PMC328422919903920 | — | — | — |
| Didelez V , Sheehan N . 2007 Mendelian randomization as an instrumental variable approach to causal inference. Stat Methods Med Res 16(4):309–330.1771515910.1177/0962280206077743 | — | — | — |
| Do R , Willer CJ , Schmidt EM , Sengupta S , Gao C , Peloso GM , Gustafsson S , Kanoni S , Ganna A , Chen J and others. 2013 Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 45: 1345–1352.2409706410.1038/ng.2795PMC3904346 | — | — | — |
| Duval S , Tweedie R . 2000 Trim and fill: a simple funnel‐plot‐based method of testing and adjusting for publication bias in meta‐analysis. Biometrics 56: 455–463.1087730410.1111/j.0006-341x.2000.00455.x | — | — | — |
| Egger M , Smith GD , Schneider M , Minder C . 1997 Bias in meta‐analysis detected by a simple, graphical test. Br Med J 315(7109):629–634.931056310.1136/bmj.315.7109.629PMC2127453 | — | — | — |
| Freeman G , Cowling B , Schooling M . 2013 Power and sample size calculations for Mendelian randomization studies. Int J Epidemiol 42(4):1157–1163.2393431410.1093/ije/dyt110 | — | — | — |
| Global Lipids Genetics Consortium . 2013 Discovery and refinement of loci associated with lipid levels. Nat Genet 45:1274–1283.2409706810.1038/ng.2797PMC3838666 | — | — | — |
| Glymour M , Tchetgen Tchetgen E , Robins J . 2012 Credible Mendelian randomization studies: approaches for evaluating the instrumental variable assumptions. Am J Epidemiol 175(4):332–339.2224704510.1093/aje/kwr323PMC3366596 | — | — | — |
| Greco M , Minelli C , Sheehan NA , Thompson JR . 2015 Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome. Stat Med 34(21):2926–2940.2595099310.1002/sim.6522 | — | — | — |
| Greenland S . 2000 An introduction to instrumental variables for epidemiologists. Int J Epidemiol 29(4):722–729.1092235110.1093/ije/29.4.722 | — | — | — |
| Han C . 2008 Detecting invalid instruments using L1‐GMM. Econ Lett 101: 285–287. | — | — | — |
| Hernán M , Hernández‐Díaz S , Robins J . 2004 A structural approach to selection bias. Epidemiology 15(5):615–625.1530896210.1097/01.ede.0000135174.63482.43 | — | — | — |
| Holmes MV , Asselbergs FW , Palmer TM , Drenos F , Lanktree MB , Nelson CP , Dale CE , Padmanabhan S , Finan C , Swerdlow DI and others. 2015 Mendelian randomization of blood lipids for coronary heart disease. Eur Heart J 36(9):539–550.2447473910.1093/eurheartj/eht571PMC4344957 | — | — | — |
| Johnson T . 2013 Efficient calculation for multi‐SNP genetic risk scores. Technical report The Comprehensive R Archive Network. Available at http://cran.r‐project.org/web/packages/gtx/vignettes/ashg2012.pdf [last accessed 2014/11/19]. | — | — | — |
| Kang H , Zhang A , Cai T , Small D . 2015 Instrumental variables estimation with some invalid instruments, and its application to Mendelian randomisation. J Am Stat Assoc. Available online before print. | — | — | — |
| Kolesár M , Chetty R , Friedman J , Glaeser E , Imbens G . 2014 Identification and inference with many invalid instruments. J Bus Econ Stat. Available online before print. | — | — | — |
| Lawlor D , Harbord R , Sterne J , Timpson N , Davey Smith G . 2008 Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med 27(8):1133–1163.1788623310.1002/sim.3034 | — | — | — |
| Linsel‐Nitschke P , Götz A , Erdmann J , Braenne I , Braund P , Hengstenberg C , Stark K , Fischer M , Schreiber S , El Mokhtari NE and others. 2008 Lifelong reduction of LDL‐cholesterol related to a common variant in the LDL‐receptor gene decreases the risk of coronary artery disease—a Mendelian randomisation study. PLoS One 3(8):e2986.1871437510.1371/journal.pone.0002986PMC2500189 | — | — | — |
| Martens E , Pestman W , de Boer A , Belitser S , Klungel O . 2006 Instrumental variables: application and limitations. Epidemiology 17(3):260–267.1661727410.1097/01.ede.0000215160.88317.cb | — | — | — |
| Nitsch D , Molokhia M , Smeeth L , DeStavola B , Whittaker J , Leon D . 2006 Limits to causal inference based on Mendelian randomization: a comparison with randomized controlled trials. Am J Epidemiol 163(5):397–403.1641034710.1093/aje/kwj062 | — | — | — |
| Pedersen TR , Kjekshus J , Berg K , Haghfelt T , Faergeman O , Faergeman G , Pyörälä K , Miettinen T , Wilhelmsen L , Olsson AG , Wedel H . 1994 Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 344(8934):1383–1389.7968073 | — | — | — |
| Pickrell J . 2015 Detection and interpretation of shared genetic influences on 40 human traits Technical report, bioRxiv. Available at http://biorxiv.org/content/early/2015/04/16/018150.10.1038/ng.3570PMC520780127182965 | — | — | — |
| Pierce B , Burgess S . 2013 Efficient design for Mendelian randomization studies: subsample and two‐sample instrumental variable estimators. Am J Epidemiol 178(7):1177–1184.2386376010.1093/aje/kwt084PMC3783091 | — | — | — |
| Schwartz GG , Olsson AG , Abt M , Ballantyne CM , Barter PJ , Brumm J , Chaitman BR , Holme IM , Kallend D , Leiter LA and others. 2012 Effects of dalcetrapib in patients with a recent acute coronary syndrome. New Engl J Med 367(22):2089–2099.2312625210.1056/NEJMoa1206797 | — | — | — |
| Thomas D , Lawlor D , Thompson J . 2007 Re: estimation of bias in nongenetic observational studies using “Mendelian triangulation” by Bautista et al. Ann Epidemiol 17(7):511–513.1746653510.1016/j.annepidem.2006.12.005 | — | — | — |
| Voight BF , Peloso GM , Orho‐Melander M , Frikke‐Schmidt R , Barbalic M , Jensen MK , Hindy G , Hólm H , Ding EL , Johnson T and others. 2012 Plasma HDL cholesterol and risk of myocardial infarction: a Mendelian randomisation study. Lancet 380(9841):572–580.2260782510.1016/S0140-6736(12)60312-2PMC3419820 | — | — | — |
| Windmeijer F , Farbmacher H , Davies N , Davey Smith G , White I . 2015 Selecting (in)valid instruments for instrumental variables estimation. Available at http://www.hec.unil.ch/documents/seminars/iems/1849.pdf.10.1080/01621459.2018.1498346PMC681732931708716 | — | — | — |
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| ABCC2 as a drug target for post-stroke recovery: Evidence from Mendelian randomization and colocalization analyses. | Gui J et al. | — | 2026 | → |
| A bidirectional 2-sample Mendelian randomization study of depressed mood and premature ovarian insufficiency. | Chen K et al. | — | 2026 | → |
| A gut microbiome-kidney-heart axis predictive of future cardiovascular diseases. | Chechi K et al. | — | 2026 | → |
| Alcohol consumption and molecular subtypes of colorectal cancer: pooled observational and Mendelian randomization analyses. | Chalitsios CV et al. | — | 2026 | → |
| A Linear Mixed Model With Measurement Error Correction (LMM-MEC): A Method for Summary-Data-Based Multivariable Mendelian Randomization. | Ding M et al. | — | 2026 | → |
| A linear-no-threshold association between carotid intima-media thickness and cognitive function: The mediating role of cerebrovascular disease. | Zhang W et al. | — | 2026 | → |
| Alterations of gut microbiome in chronic rhinosinusitis: insights from a mendelian randomization study. | Wang KS et al. | — | 2026 | → |
| A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders. | Jang B et al. | — | 2026 | → |
| Ancestry-specific genetics of amino acids and microbiota-related metabolites reveal causal effects on cardiometabolic disease in Chinese populations. | Ding Y et al. | — | 2026 | → |
| An oral, liver-restricted LXR inverse agonist for dyslipidemia: preclinical development and phase 1 trial. | Li X et al. | — | 2026 | → |
| A potential drug target in epilepsy and its role in other neurological disorders. | Gao S et al. | — | 2026 | → |
| Assessing the bidirectional causal relationship between malnutrition, self-reported fatigue, and stroke: A 2-sample Mendelian randomization study. | Luo M et al. | — | 2026 | → |
| Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study. | Morales-Berstein F et al. | — | 2026 | → |
| Association between asthma and myopia: the NHANES database and Mendelian randomization analysis. | Zheng YJ et al. | — | 2026 | → |
| Association between chronic kidney disease and sarcopenia: a national cohort study and two-step Mendelian randomization analysis. | Wang H et al. | — | 2026 | → |
| Association between epigenetic age acceleration and psychiatric disorders: a bidirectional Mendelian randomization study. | Hong Y | — | 2026 | → |
| Association between gut microbiota and spontaneous abortion: A two-sample Mendelian randomization study. | Tang C et al. | — | 2026 | → |
| Association between immune cells and multiple cancers: Insights from Mendelian randomization and gene-based analysis. | Tang M et al. | — | 2026 | → |
| Association between type 2 diabetes and autoimmune liver disease: An integrated analysis of Mendelian randomization and clinical samples. | Wen L et al. | — | 2026 | → |
| Association of IGF-1 Levels With Height From Childhood to Adulthood: An Observational and Mendelian Randomization Study. | De La Barrera B et al. | — | 2026 | → |
| Association of oral microbiota and digestive system cancers revealed by bidirectional two sample Mendelian randomization. | Zhang YJ et al. | — | 2026 | → |
| Associations of blood cell indices with the severity of rheumatoid arthritis: a retrospective case-control and machine learning modeling study. | He R et al. | — | 2026 | → |
| Associations of loneliness and social isolation with the risk of suicide attempts: Insights from an observational and genetic analysis. | Hu W et al. | — | 2026 | → |
| Astragalus polysaccharide ameliorates neuroinflammation in EAE mice by modulating microglial autophagy to reduce lipid droplet accumulation. | Wang X et al. | — | 2026 | → |
| A systematic exploration of gut microbiota-driven blood metabolites in sepsis: an integrated bioinformatics and genetic association study. | Zhang Y et al. | — | 2026 | → |
| A two-sample Mendelian randomization study and mediation analysis exploring the link between cathepsins and epilepsy. | Sun H et al. | — | 2026 | → |
| BACH1 is stabilized by vitamin E and attenuates the formation of hypertrophic scar through the Wnt/β-catenin pathway. | Luan W et al. | — | 2026 | → |
| Bidirectional Mendelian Randomization and Colocalization Study of Memory B Cells and Major Depressive Disorder. | Si SM et al. | — | 2026 | → |
| Bidirectional Mendelian Randomization Study: Unraveling the Link Between Idiopathic Pulmonary Fibrosis and Cardiovascular Disease. | Hu L et al. | — | 2026 | → |
| Blood neurofilament light chain as a biomarker for cognitive impairment in adults with epilepsy: Integrated evidence from clinical cohorts in Northeast China and European GWAS data. | Chen Z et al. | — | 2026 | → |
| Brain age gap as biomarker linking cardiovascular diseases genetic susceptibility and causality. | Lyu S et al. | — | 2026 | → |
| Brain structures mediate the causal effects of socioeconomic status on mental disorders: A multi-stage Mendelian randomization study. | Pan S et al. | — | 2026 | → |
| Cardiometabolic Dysregulation and PON1 Genetic Susceptibility in Chronic E-waste Recyclers Exposed to Potentially Toxic Elements. | Shoukat A et al. | — | 2026 | → |
| Cardiorespiratory fitness, grip strength and depression symptoms: A Mendelian Randomization study. | Vincent J et al. | — | 2026 | → |
| Cathepsin H as a causal risk factor and therapeutic target in proliferative diabetic retinopathy. | Zhou Q et al. | — | 2026 | → |
| Causal association and potential mediators between obstructive sleep apnea and diabetic nephropathy: A Mendelian randomization study. | He Y et al. | — | 2026 | → |
| Causal association between benign anorectal disorders and mental disorders: A Mendelian randomization study. | Wu X et al. | — | 2026 | → |
| Causal association between circulating leukocyte characteristics and diabetic retinopathy based on two-sample Mendelian randomization. | Wang Y et al. | — | 2026 | → |
| Causal Association Between Commonly Used Medicines and Diabetes-Related Eye Diseases: Univariable and Multivariable Mendelian Randomization Study. | Wang Y et al. | — | 2026 | → |
| Causal association between matrix metalloproteinases and gout: A two-sample mendelian randomization study. | Chen DW et al. | — | 2026 | → |
| Causal association between metformin and arrhythmias: A Mendelian randomization study. | Qin WP et al. | — | 2026 | → |
| Causal association between sarcopenia and iron deficiency anemia: A two-sample Mendelian randomization study. | Li B et al. | — | 2026 | → |
| Causal association between sleep disorders and delirium: A bidirectional mendelian randomization analysis for clinical practice. | Niu W et al. | — | 2026 | → |
| Causal Association Between Transferrin Saturation and Periodontitis: A Mendelian Randomization Study. | Gao J | — | 2026 | → |
| Causal associations between ankylosing spondylitis and cardiovascular disease: a mendelian randomization analysis. | Zhou L et al. | — | 2026 | → |
| Causal Associations Between Human Blood Metabolites and Cardio-Cerebrovascular Diseases: A Mendelian Randomisation Study. | Zhang H et al. | — | 2026 | → |
| Causal Associations Between Sleep Traits and Polycystic Ovary Syndrome: A Univariable, Bidirectional, and Multivariable Mendelian Randomization Study. | Chen X et al. | — | 2026 | → |
| Causal associations of specific immunoglobulin G N-glycosylation subtypes with osteoporosis: A two-sample Mendelian randomization. | Zhao Y et al. | — | 2026 | → |
| Causal effects of drug exposure on gastric cancer risk: a Mendelian randomization study involving 23 commonly used medications in the European population. | Zhang G et al. | — | 2026 | → |
| Causal effects of gut microbiota and blood metabolites on subtypes of perinatal depression classified based on depressive symptom trajectories: a mendelian randomization study. | Li H et al. | — | 2026 | → |
| Causal effects of inflammatory bowel disease on brain structure: A Mendelian randomization study. | He Y et al. | — | 2026 | → |
| Causal effects of single-carbon metabolism and vitamin levels on autism spectrum disorder risk: a bidirectional Mendelian randomized study. | Zhu J et al. | — | 2026 | → |
| Causal Exposures of Immune Cells in Neuromyelitis Optica Spectrum Disorders: A Mendelian Randomization Study and Flow Cytometry Analysis. | Ren J et al. | — | 2026 | → |
| Causal inference in psychiatric research: how to critically evaluate and interpret mendelian randomization studies. | Garcia-Argibay M et al. | — | 2026 | → |
| Causal interplay between trigeminal neuralgia and systemic inflammatory markers: A bidirectional Mendelian randomization study. | Hou L et al. | — | 2026 | → |
| Causality between immune cells and HER2-breast cancer: A 2‑sample Mendelian randomization study. | Zhang M et al. | — | 2026 | → |
| Causality of atrial fibrillation and left atrial traits: Genetic and epigenetic perspectives. | Cai D et al. | — | 2026 | → |
| Causal links among gut microbiota, immune-inflammatory and compensatory immune-regulatory systems, and schizophrenia. | Yang BZ et al. | — | 2026 | → |
| Causal relationship between consumption of different tea types and the risk of stroke: A two-sample Mendelian randomization analysis. | Jiang X et al. | — | 2026 | → |
| Causal relationship between Helicobacter pylori and periodontal disease: Two-sample Mendelian randomization study. | Wang H et al. | — | 2026 | → |
| Causal relationship between matrix metalloproteinases and diabetic retinopathy: A bidirectional two-sample Mendelian randomization study. | Qiu X et al. | — | 2026 | → |
| Causal relationship between mental illness and venous thromboembolism: a Mendelian randomization study. | Jin et al. | — | 2026 | → |
| Causal Relationship Between Neurotrophins and Normal Pressure Hydrocephalus: Insights From a Bidirectional Two-Sample Mendelian Randomization Study. | Xu T et al. | — | 2026 | → |
| Causal relationship between obesity, leptin, and brain structure and functional connectivity: evidence based on bidirectional and mediation mendelian randomisation analyses. | Wu Y et al. | — | 2026 | → |
| Causal relationships between ADHD, ASD and brain structure: A mendelian randomization study. | Zhao Y et al. | — | 2026 | → |
| Causal relationships between alzheimer's disease genetics and brain connectivity alterations: a multi-modal mendelian randomization study with transcriptomic validation of 191 rs-fMRI and 635 DTI neuroimaging traits. | Ji J et al. | — | 2026 | → |
| Causal relationships between antibody-induced immune responses and sepsis: Evidence from genetic studies. | Li L et al. | — | 2026 | → |
| Causal Relationships Between High-Altitude Adaptation, Metabolic Traits, and Tumors: Insights from Mendelian Randomization. | Zhang X et al. | — | 2026 | → |
| Causal relationships between plasma lipidomics, trace elements, cerebrospinal fluid metabolites, and Parkinson's disease using Mendelian randomization. | Wang M et al. | — | 2026 | → |
| Causal relationships of lipid metabolism in diabetic nephropathy risk: A two-sample Mendelian randomization study. | Yu C et al. | — | 2026 | → |
| Causal role of genetically predicted impairment of branched-chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes. | Zhou X et al. | — | 2026 | → |
| Causal roles of immune cells and plasma metabolites in esophageal cancer: A Mendelian randomization study with nutritional insights. | Liu X et al. | — | 2026 | → |
| Cell senescence-related pathogenic genes in sleep disorders: a multi-omics Mendelian randomization study. | Li J et al. | — | 2026 | → |
| Cerebrospinal fluid metabolites and multiple sclerosis: A two-sample Mendelian randomization study. | Zhang D et al. | — | 2026 | → |
| Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study. | Zhang Y et al. | — | 2026 | → |
| Chronic periodontitis and respiratory diseases: A bidirectional two-sample Mendelian randomization study. | Ye H et al. | — | 2026 | → |
| Circulating levels of insulin-like growth factor I (IGF-I) and risk of multiple myeloma: An observational and Mendelian randomisation study. | Benavente Y et al. | — | 2026 | → |
| Circulating metabolites mediating the effect of psoriatic arthritis on Crohn disease risk: A mediation Mendelian randomization study. | Qin X et al. | — | 2026 | → |
| Circulating Proteins Link Obesity With Cardiac Remodeling: Insights From Mendelian Randomization. | Mao Y et al. | — | 2026 | → |
| Class-Specific Antihypertensives and Alzheimer's Disease: Genotype- and Hypertension-Stratified Analysis. | Yang D et al. | — | 2026 | → |
| Combining single-cell analysis and Mendelian randomization to elucidate the molecular mechanisms of fibronectin-related genes in multiple sclerosis. | Zhao N et al. | — | 2026 | → |
| Constructing a protein-protein interaction network for autoimmune liver diseases by integrating pQTL, rQTL, and mediation analyses. | Tian D et al. | — | 2026 | → |
| Convergent Multistage Evidence Implicates the CCR2-Artemin Immune-Inflammation Axis in Acute Myeloid Leukemia. | Jin Y et al. | — | 2026 | → |
| Cortical structural variations and scoliosis risk: insights from a large-scale Mendelian randomization analysis. | Ma H et al. | — | 2026 | → |
| Cross-phenotype genome-wide association study supports shared genetic etiology between skin and gastrointestinal tract diseases. | Peng B et al. | — | 2026 | → |
| Cross-trait genomic and sequential analyses of multiple omics datasets identified shared genetic components for the gut-eye axis. | Gao Y et al. | — | 2026 | → |
| Cumulative adverse childhood experiences increase migraine risk in later life in China: evidence from CHARLS with mediation and Mendelian randomization. | Duan L et al. | — | 2026 | → |
| Deciphering the causal influence of BMI and related metabolic, inflammatory, and cardiovascular factors on brain structure: a Mendelian Randomization Study. | Painter JN et al. | — | 2026 | → |
| Deciphering the shared genetic architecture between female reproductive disorders and psychiatric disorders. | Li N et al. | — | 2026 | → |
| Deriving Mendelian Randomization-Based Causal Networks of Brain Imaging Phenotypes and Bipolar Disorder. | O'Connell S et al. | — | 2026 | → |
| Development and validation of a diagnostic machine learning model for gastric cancer risk based on double-negative T cell-related features. | Yin Z et al. | — | 2026 | → |
| Diagnostic value of mitochondria-related genes in intervertebral disc degeneration associated with spinal metastasis: a Mendelian randomization study. | Liu L et al. | — | 2026 | → |
| Differential modulation of gestational immunity by fatty acids: tissue-specific immune remodeling and clinical implications. | Chen J et al. | — | 2026 | → |
| Discovery of circadian rhythm-related hub genes in acute myocardial infarction: A two-sample Mendelian randomization study. | Peng S et al. | — | 2026 | → |
| Disentangling the Effect of BMI on Hepatocellular Carcinoma From Cirrhosis With Multivariable Mendelian Randomization. | Gkatzionis A et al. | — | 2026 | → |
| Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study. | Mason AC et al. | — | 2026 | → |
| Dissecting the Mediating Role of Cortical Structures in the Pathogenesis of Socioeconomic Status to ADHD: A Mendelian Randomization Study and Mediation Analysis. | Xie W et al. | — | 2026 | → |
| Distinct roles of chronotype, daytime napping, and sleep duration in biological and functional aging: a univariable and multivariable Mendelian randomization study. | Zhang Z et al. | — | 2026 | → |
| Divergent Patterns of Genetic Overlap Between Severe Mental Disorders and Metabolic Markers. | van der Meer D et al. | — | 2026 | → |
| Effect of type 1 diabetes on oral lichen planus mediated by IL-10. | Chen X et al. | — | 2026 | → |
| Effects of artificial sweeteners on coronary heart disease: A 2-way 2-sample Mendelian randomization study and mediation analysis. | Sun S et al. | — | 2026 | → |
| Elucidating biopsychosocial mechanisms in migraine: an integrative analytics approach combining genetics, neuroimaging, and machine learning. | Liu YC et al. | — | 2026 | → |
| Elucidating Causal Associations Between Immune Cells, Circulating Inflammatory Proteins, and Chronic Inflammatory Demyelinating Polyneuropathy: A Two-Sample Two-Step Mendelian Randomization Study. | Wang AC et al. | — | 2026 | → |
| Explainable AI multiomics analysis reveals shared and divergent host responses in COVID-19 and influenza. | Zhang Y et al. | — | 2026 | → |
| Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study. | Chang S et al. | — | 2026 | → |
| Exploring estrogen synthesis and metabolism related markers and immune dynamics in osteoporosis-insights from single-cell RNA sequencing and Mendelian randomization. | Hao X et al. | — | 2026 | → |
| Exploring Potential Associations Between HIV Acquisition and Biological Aging: Insights from a Bidirectional Mendelian Randomization Study. | Wang H et al. | — | 2026 | → |
| Exploring the association of age at first sexual intercourse and lifetime number of sexual partners on neurological and psychiatric disorders: An observational and genetic study. | Dong Y et al. | — | 2026 | → |
| Exploring the causal association between body composition and primary ovarian insufficiency: A retrospective cohort study and Mendelian randomization analyses. | Zheng J et al. | — | 2026 | → |
| Exploring the causal effect of genetically predicted blood and cerebrospinal fluid metabolites and metabolic pathways on intracranial aneurysm. | Ding L et al. | — | 2026 | → |
| Exploring the genetically predicted gut microbiota-reproductive axis: Impact on anti-Müllerian hormone levels. | Liao CC et al. | — | 2026 | → |
| Exploring the Genetic Association and Genetic Architecture of Iridocyclitis and Extraocular Autoimmune Diseases. | Yuan F et al. | — | 2026 | → |
| Facial skin aging is a potential osteoporosis-associated marker: evidence from both observational and genetic studies. | Yu ZD et al. | — | 2026 | → |
| Female Reproductive Traits and Late-Life Hormone-Sensitive Cancer Risk: A Mendelian Randomization Study. | Li Z et al. | — | 2026 | → |
| From gut to glymphatic system: Causal pathways converge in midbrain glutamatergic neurons. | Li B et al. | — | 2026 | → |
| Genetically predicted anti‑rubella virus IgG levels and dermatitis risk: A two‑sample Mendelian randomization study. | Ouyang Z et al. | — | 2026 | → |
| Genetically predicted artificial sweeteners and stroke susceptibility: a multivariable Mendelian randomization study. | Song Z et al. | — | 2026 | → |
| Genetically predicted associations between blood cell perturbation responses and bronchiectasis through immune mediation: A Mendelian Randomization study. | Han J et al. | — | 2026 | → |
| Genetically Predicted Levels of Lipoprotein(a) and Risk of Cerebrovascular Disease. | Daghlas I et al. | — | 2026 | → |
| Genetically predicted plasma metabolites mediate the relation between inflammatory factors and Meniere's disease. | Wang J et al. | — | 2026 | → |
| Genetically Validated Immune Susceptibility Markers for Crohn's Disease: A Multi-Omics Mendelian Randomization Analysis. | Li Z | — | 2026 | → |
| Genetic and epidemiological insights into the role of neutrophil percentage in heart failure risk: a Mendelian randomization and NHANES study. | Gao Y et al. | — | 2026 | → |
| Genetic Association Between Rheumatoid Arthritis and Preeclampsia: A Bidirectional Mendelian Randomization and Bioinformatics Study. | Li L et al. | — | 2026 | → |
| Genetic Association of Circulating Proteins and Gene Transcripts With Spontaneous Coronary Artery Dissection. | Ardissino M et al. | — | 2026 | → |
| Genetic Evidence for Causal Effects of Blood Metabolites on Age-Related Macular Degeneration and its Subtypes. | Zhang K et al. | — | 2026 | → |
| Genetic evidence for causal effects of lifestyle factors, psychiatric factors, and socioeconomic status on various spinal disorders. | Shao J et al. | — | 2026 | → |
| Genetic evidence for causal relationship between general cognition and treatment resistance in schizophrenia. | Li C et al. | — | 2026 | → |
| Genetic evidence for the association between schizophrenia and obesity. | Su MH et al. | — | 2026 | → |
| Genetic evidence for the causal relationship between metabolic diseases and primary aldosteronism: insights from Mendelian randomization analysis. | Zhang H et al. | — | 2026 | → |
| Genetic evidence from proteome-wide analysis identifies plasma proteins driving risk of respiratory tract infections. | Yuan Y et al. | — | 2026 | → |
| Genetic evidence of the causal relationship between genetically predicted nutrients and psoriatic arthritis. | Zhao J et al. | — | 2026 | → |
| Genetic Evidence Reveals Causal Effect of Circulating Proteome on Random Glucose: A Mendelian Randomization Study. | Shen Z et al. | — | 2026 | → |
| Genetic evidence supporting obesity as a risk factor for lung squamous cell carcinoma and the identification of MFAP1 as a shared genetic target. | Xu K et al. | — | 2026 | → |
| Genetic insights into therapeutic targets for gestational diabetes mellitus: a multi-omics analysis. | Li Q et al. | — | 2026 | → |
| Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve. | Thériault S et al. | — | 2026 | → |
| Genome-wide cross-trait analyses reveal shared genetic architecture and causal links between attention-deficit/hyperactivity disorder and cardiovascular diseases. | Liu HY et al. | — | 2026 | → |
| Genomic and AI-driven discovery in chronic prostatitis: Causal role of ITPR3 and therapeutic repurposing of raloxifene. | Li Y et al. | — | 2026 | → |
| Genomic approach to investigate air pollution's causal impact on neurodevelopment and mental health: An extensive-scale 2-sample Mendelian randomization study. | Wu W et al. | — | 2026 | → |
| Global, Population and Genetic Evidence on the Relationships Between Immune-Mediated Inflammatory Disease and Cancer Risk. | Dong X et al. | — | 2026 | → |
| GLP-1R agonists and heart failure: novel beneficial effects suggested by Mendelian randomization. | Hu Y et al. | — | 2026 | → |
| Gut microbiota as potential mediator linking dietary preferences and aging phenotypes. | Li W et al. | — | 2026 | → |
| Gut microbiota, immune cells, and postpartum depression: A mediation Mendelian randomization study. | Zhou B et al. | — | 2026 | → |
| Gut microbiota's causal effect on physical activity: Insights from two-sample Mendelian randomization analysis. | Meng D et al. | — | 2026 | → |
| Helicobacter pylori infection is causally associated with extra-gastric tumors: a Mendelian randomization study. | Liu J et al. | — | 2026 | → |
| Histone lactatation-related genes GPR19 and SLC22A16 are important diagnostic markers and drug treatment targets for prostate cancer. | Yan Y et al. | — | 2026 | → |
| Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis. | Alhathli E et al. | — | 2026 | → |
| Identification of immune cells in benign and malignant thymus tumors: a Mendelian randomization study. | Yan N et al. | — | 2026 | → |
| Identification of mitochondrial dynamics-related biomarkers in psoriasis using bioinformatics and Mendelian randomization. | Zhang B et al. | — | 2026 | → |
| Identification of potential drug targets for delirium from genetic insights: A Mendelian randomization study. | Geng YN et al. | — | 2026 | → |
| IL-1β Signaling, Obesity, and Venous Thromboembolism: A Mendelian Randomization Study. | Sun B et al. | — | 2026 | → |
| Imaging and genome-supported association of glymphatic system function and multiregional brain characteristics with Parkinson's disease. | Ye Z et al. | — | 2026 | → |
| Immune cells influence major depression through metabolites: A Mendelian randomization analysis of bidirectional causality and mediating effects. | Kong Z et al. | — | 2026 | → |
| Immune cells mediated the causal relationship between gut microbiota and carpal tunnel syndrome: A Mendelian randomization study. | Li JA et al. | — | 2026 | → |
| Impacts of host genetics on gut microbiome composition in Alzheimer's disease. | Liu J et al. | — | 2026 | → |
| Inflammation as a mediator of air pollution's role in Alzheimer's disease and related dementias. | Zhao B et al. | — | 2026 | → |
| Inflammatory cytokines are not associated with early age-related macular degeneration: a two-sample Mendelian randomisation study. | Dai Y et al. | — | 2026 | → |
| Insulin resistance increases stroke risk: a cross-sectional study from NHANES 1999-2018 and a Mendelian randomization study. | Hu Y et al. | — | 2026 | → |
| Integrated multi-omics identifies macrophage ARG1-mediated deacetylation with causal and diagnostic implications in ischemic stroke. | Ruan HZ et al. | — | 2026 | → |
| Integrative genomics establishes GNL3 as a pleiotropic hub and causal gene for osteoarthritis. | Qu T et al. | — | 2026 | → |
| Investigating the association between uterine fibroids and weight-bearing joint osteoarthritis based on a bidirectional Mendelian randomization study. | Ma X et al. | — | 2026 | → |
| Investigating the relationship between dietary vitamin B12 and bone mineral density: Observational and genetic analyses. | Zhong Y et al. | — | 2026 | → |
| Investigating the relationship between taste perception of artificial sweeteners and cancer risk. | Crick DCP et al. | — | 2026 | → |
| Investigating the Shared Genetic Architecture of 3 Age-Related Ocular Disorders. | Bai ZP et al. | — | 2026 | → |
| Knowledge-graph embeddings for osteoarthritis candidate prediction. | Wang Z et al. | — | 2026 | → |
| Leveraging genetic propensity to identify modifiable factors for the age at onset of Alzheimer's disease. | Li YJ et al. | — | 2026 | → |
| Lifecourse genome-wide association study meta-analysis refines the critical life stages for adiposity's influence on breast cancer risk. | Power GM et al. | — | 2026 | → |
| MACFIV: a novel framework for nonlinear causal inference in the body mass index-hypertension relationship with many weak and pleiotropic genetic instruments. | Chen D et al. | — | 2026 | → |
| Malignant neoplasm of skin with risk of sepsis: A bidirectional Mendelian randomization analysis. | Pan L et al. | — | 2026 | → |
| Mapping the genetically predicted associations of plasma metabolites with sarcopenia and aging traits: Evidence from bidirectional Mendelian randomization and transcriptome analysis. | Wang Q et al. | — | 2026 | → |
| Maternal and fetal genetic predispositions to insulin deficiency and resistance affect fetal growth through distinct pathways. | Yu G et al. | — | 2026 | → |
| Maternal migraine and offspring ADHD: triangulating the evidence. | Luo Y et al. | — | 2026 | → |
| May obesity increase the risk of lymphoma? Insights from genetic evidence. | Liu J et al. | — | 2026 | → |
| Mediators between gut microbiota and Alzheimer's disease: A mediation Mendelian randomization study. | Dong XY et al. | — | 2026 | → |
| Mendelian randomization analyses support causal relationships between COVID-19 and changes in brain structure and function. | Wang Q et al. | — | 2026 | → |
| Mendelian randomization analysis of the causal relationship between low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and androgenic alopecia. | Fu M et al. | — | 2026 | → |
| Mendelian randomization analysis of the causal relationship between micronutrients and childhood asthma. | Liu Z et al. | — | 2026 | → |
| Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging-Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases. | Chen J et al. | — | 2026 | → |
| Mendelian Randomization and ScTranscriptomics Reveal a Lipid Low Malignant Cells Driving Immunosuppression and Matrix Remodeling in Oral squamous cell carcinoma. | Su K et al. | — | 2026 | → |
| Mendelian randomization applied to migraine research: Opportunities and challenges. | Daghlas I et al. | — | 2026 | → |
| Mendelian randomization identifies causal effects of phospholipids on portal vein thrombosis risk: FADS1/2-mediated pathways and their potential as diagnostic biomarkers. | Wang Y | — | 2026 | → |
| Mendelian randomization identifies multiple immune cell surface markers as potential causal contributors and drug targets in rheumatoid arthritis. | Huang G et al. | — | 2026 | → |
| Mendelian Randomization Methods for Causal Inference: Estimands, Identification and Inference. | Yao M et al. | — | 2026 | → |
| Mendelian randomization reveals the associations between modifiable risk factors and intermediate phenotypes and spontaneous abortion. | Guo W et al. | — | 2026 | → |
| Mendelian randomization study: investigating the causal impact of Covid-19 on adverse pregnancy outcomes. | Tang R et al. | — | 2026 | → |
| Mendelian Randomization Study of Age-Related Macular Degeneration and Inflammatory Bowel Disease. | Hua Z et al. | — | 2026 | → |
| Mendelian Randomization Study on Serum Metabolites and Diabetic Nephropathy Risk: Identifying Potential Biomarkers for Early Intervention. | Song S et al. | — | 2026 | → |
| Metabolome Wide Mendelian Randomization Assessing the Causal Relationship Between Serum Metabolites, Cerebrospinal Metabolites, and Aneurysmal Subarachnoid Hemorrhage. | Song B et al. | — | 2026 | → |
| Metabolomic insights into associations between adiposity markers and liver cancer risk: Results from a prospective cohort study and Mendelian randomization analysis. | Li ZY et al. | — | 2026 | → |
| Metabolomic Profile of Genetic Liability to Type 2 Diabetes Among 125,000 Mexican Adults: A Mendelian Randomization Study. | Bragg F et al. | — | 2026 | → |
| Mind the gap: Characterizing bias due to population mismatch in two-sample Mendelian randomization. | Li J et al. | — | 2026 | → |
| Multi-ancestry genome-wide association and integrated multi-omics analyses of endometriosis and its clinical manifestations. | Koller D et al. | — | 2026 | → |
| Multivariable Mendelian randomization analysis reveals the protective effect of restless legs syndrome against lower limb venous diseases and pulmonary embolism. | Zhang RY et al. | — | 2026 | → |
| Neutrophil extracellular traps-associated candidate genes in IgA vasculitis: an exploratory multi-omics analysis integrating transcriptomics and Mendelian randomization. | Lin L et al. | — | 2026 | → |
| Novel insights into the causal effects of triglycerides to high density lipoprotein cholesterol ratio on blood pressure. | Wan A et al. | — | 2026 | → |
| Novel Plasma Proteomic Markers and Risk of Venous Thromboembolism. | Tang W et al. | — | 2026 | → |
| Oxidative Stress-Related Genome-Wide Mendelian Randomization Identifies Causal Genes for Coronary Artery Disease. | Zhang H et al. | — | 2026 | → |
| Plasma Proteome Signature for Leukocyte Telomere Length and Its Link to Abdominal Aortic Aneurysm. | Li A et al. | — | 2026 | → |
| Platelet indices as prognostic biomarkers in lung cancer: A meta-analysis and Mendelian randomization study. | Yuan M et al. | — | 2026 | → |
| Pleiotropic gene mapping reveals shared immune regulatory hubs across 15 autoimmune diseases. | Jin Y et al. | — | 2026 | → |
| Powering the mind: deciphering the shared genetic architecture between mitochondrial DNA copy number and major psychiatric disorders. | Xue H et al. | — | 2026 | → |
| Protective role of PCED1B -expressing naive CD4 + T cells in sepsis. | Shang W et al. | — | 2026 | → |
| Proteome-wide Mendelian randomization and colocalization analyses identify novel protein targets for cardiac conduction disorders. | Song ZQ et al. | — | 2026 | → |
| Relationship between genetically determined telomere length and childhood glioma risk. | Zhou N et al. | — | 2026 | → |
| Relationship between the microbiome and obesity-associated cancer risk using Mendelian randomisation. | Yates T et al. | — | 2026 | → |
| Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization. | Taylor-Bateman V et al. | — | 2026 | → |
| Right and Left Atrial Dysfunction as Independent Cardiovascular Risk Factors: A UK Biobank Study. | Yogeswaran V et al. | — | 2026 | → |
| Risk insights for clinical medication: a Mendelian randomization study of 23 drugs and lung cancer. | Wang H et al. | — | 2026 | → |
| Role of CD127 on CD28<sup>+</sup> CD45RA<sup>+</sup> CD8<sup>br</sup> Treg Cells in Mediating the Association Between GDF-15 and Sarcopenia. | Pan Y et al. | — | 2026 | → |
| Role of CD25 on resting Treg immune cell in mediating the effect of stearate biosynthesis microbiome pathway on lung adenocarcinoma. | Yang L et al. | — | 2026 | → |
| Role of TRAIL in mediating the effect of lipidome on breast cancer: a Mendelian randomization study. | Wang X et al. | — | 2026 | → |
| Role of Transitional %B Cells in Mediating the Effect of Phosphatidylinositol (16:0_18:1) on Aortic Dissection. | Ma L et al. | — | 2026 | → |
| Screen Time and Chronic Pain Health: Mendelian Randomization Study. | Jiang J et al. | — | 2026 | → |
| Sedentary behaviour, muscle diseases, fractures: Mendelian randomisation study. | Qin H et al. | — | 2026 | → |
| Serum cystatin C as a biomarker for diabetic retinopathy and its role in diabetic retinopathy-diabetic kidney disease comorbidity. | Chen X et al. | — | 2026 | → |
| Serum Minerals and Male Age-related Hypogonadism: Multimodal Evidence Decoding Associations and Intervention Strategies. | Xie J et al. | — | 2026 | → |
| Shared genetic architecture of psychiatric disorders and ocular diseases: Evidence from genome-wide analyses. | Zhang ZY et al. | — | 2026 | → |
| Shared Genetic Basis Between Systemic Lupus Erythematosus and Inflammatory Bowel Disease in East Asian Ancestry: A Genome-Wide Cross-trait Analysis. | Mo X et al. | — | 2026 | → |
| Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers. | Buyukkurt A et al. | — | 2026 | → |
| SLC22A3 deficiency leads to cognitive impairment through the cardio-neuroinflammatory axis mediated HA/H1R/NLRP3 pathway in heart failure mice. | Wang Z et al. | — | 2026 | → |
| Smoking behaviour, altered DNA methylation, and heart failure risk: evidence from a prospective cohort and epigenetic Mendelian randomization study. | Song ZQ et al. | — | 2026 | → |
| Social isolation and 59 common health conditions: insights from observational and genetics analyses. | Ai S et al. | — | 2026 | → |
| Study on the bidirectional causal relationship between visceral adipose tissue and heart failure: Multivariate Mendelian randomization and mediation analysis. | Liao J et al. | — | 2026 | → |
| Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for osteomyelitis. | Chai W et al. | — | 2026 | → |
| Systematic review and meta-analysis of Mendelian randomization in delirium studies: Key findings and methodological issues. | Tao H et al. | — | 2026 | → |
| Systemic interleukin signaling and Alzheimer's disease risk: A two-sample cross-replication Mendelian randomization study. | Ahmed HM et al. | — | 2026 | → |
| Taste Preferences Shape Disease Susceptibility via Heritable Nutrient Predispositions: A Behavior-Gene Coevolution Framework. | Yan X et al. | — | 2026 | → |
| The Association Between Autoimmune Rheumatic Diseases and Depression: A Two-Sample Bidirectional Mendelian Randomization. | Wang H et al. | — | 2026 | → |
| The Association Between Irritable Bowel Syndrome and Generalized Anxiety Disorder and Influencing Factors: A Mediation Mendelian Randomization Study. | Yang W et al. | — | 2026 | → |
| The association between steatotic liver disease and chronic kidney disease: a meta-analysis and Mendelian randomization study highlighting metabolic comorbidities. | Ji X et al. | — | 2026 | → |
| The causal association between plasma amino acid levels and abdominal aortic aneurysm: insights from Mendelian randomization and an experimental validation. | Li M et al. | — | 2026 | → |
| The causal relationship between multiple cardiovascular diseases and glioblastoma: A Mendelian randomization study. | Lin K et al. | — | 2026 | → |
| The Causal Relationship Between Physical Activity and Sleep and Eating Disorders: Evidence From a Mendelian Randomization Analysis. | Xu D et al. | — | 2026 | → |
| The causal relationship in hypertensive encephalopathy: mechanistic analysis of five specific circulating cytokines. | Zhang P et al. | — | 2026 | → |
| The correlation between exercise and atherosclerotic cardiovascular disease: a combined analysis using NHANES data (2007-2018) and Mendelian randomization. | Zhao Z et al. | — | 2026 | → |
| The Cortical Structural Mediators of Cognitive Enhancement in Computer Game Players: Evidence From Mendelian Randomization. | Sun Y et al. | — | 2026 | → |
| The Genetic Link Between Primary Immune Thrombocytopenia and Depression/Anxiety Disorders: A Two-Sample Mendelian Randomization Study. | Jiang L et al. | — | 2026 | → |
| The genetic relationships between post-traumatic stress disorder and its corresponding neural circuit structures. | Gong Q et al. | — | 2026 | → |
| The impact of anti-gout medications on eight cardiovascular diseases: a Mendelian randomized study. | Peng P et al. | — | 2026 | → |
| The impact of different intensities of physical activity on aging: A Mendelian randomization study. | Li H et al. | — | 2026 | → |
| The Link Between Serum Copper and Diabetic Kidney Disease: A Plasma Proteomic Perspective. | Feng Z et al. | — | 2026 | → |
| The Mechanism of Gut Microbiota in Breast Cancer Based on the Bulk Transcriptome, Mendelian Randomization Analysis and Single Cell RNA Sequencing. | Luo T et al. | — | 2026 | → |
| The role of lipids in mediating the effects of immune cells on Alzheimer's disease risk: A network Mendelian randomization study. | Yang X et al. | — | 2026 | → |
| Transfer learning-based two-sample Mendelian randomization method for heterogeneous population. | Wei Y et al. | — | 2026 | → |
| Uncovering and validating biomarkers associated with RNA methylation modifications in keloids: Insights from transcriptomic and Mendelian randomization analyses. | Han P et al. | — | 2026 | → |
| Uncovering plasma protein biomarkers linked to depression: A differential abundance analysis and Mendelian randomization using large-scale data. | Abebe E et al. | — | 2026 | → |
| Unraveling the causal link between inflammatory cytokines and hypertensive renal disease: a Mendelian randomization analysis. | Gong X et al. | — | 2026 | → |
| Unveiling the mediating role of immune cells in the link between pathogen infections and Hashimoto's thyroiditis. | Zhou J et al. | — | 2026 | → |
| Using human genetics to understand the epidemiological association between child obesity at different ages and MASLD. | Ge Q et al. | — | 2026 | → |
| A Bidirectional Mendelian Randomization Study of Causal Relationships Between Migraine and White-Matter Structural Connectivity. | Tong D et al. | — | 2025 | → |
| Absence of bidirectional causality between primary biliary cholangitis and major depression: A two-sample Mendelian randomization study. | Du Q et al. | — | 2025 | → |
| A Causal Association Between Drug Use and Cognitive Impairment: A Two-Sample Mendelian Randomization Study. | Yan B et al. | — | 2025 | → |
| A Causal Inference Study of Circulating Metabolites Mediating the Effect of Obesity-Related Indicators on the Incidence of Anxiety Disorders. | Qin C et al. | — | 2025 | → |
| A causal relationship between functional connectivity of brain networks and cardiovascular disease: A Mendelian randomization study. | Chu H et al. | — | 2025 | → |
| A causal relationship between type 1 diabetes and risk of systemic sclerosis: a bidirectional two-sample Mendelian randomization study. | Huang H et al. | — | 2025 | → |
| ADHD and Differences in Brain Function as Measured by EEG: Cause or Effect? | Ahn K et al. | — | 2025 | → |
| Adiposity distribution and risks of 12 obesity-related cancers: a Mendelian randomization analysis. | Hazelwood E et al. | — | 2025 | → |
| A genetic data-based causal exploration of the relationship between docosahexaenoic acid levels and the risk of acute pancreatitis. | Yu J et al. | — | 2025 | → |
| A genome-wide association study about presbycusis and brain cortical structure: Neuroimaging traits from a Mendelian randomization study. | Gao Z et al. | — | 2025 | → |
| Age-specific childhood obesity and adult cholelithiasis: association and shared transcriptomic bases. | Liu L et al. | — | 2025 | → |
| A Mendelian analysis of the causality between inflammatory cytokines and digestive tract cancers. | Ren X et al. | — | 2025 | → |
| A Mendelian randomization analysis reveals the role of the skin microbiota in systemic lupus erythematosus. | Yin Y et al. | — | 2025 | → |
| A Mendelian randomization-based risk model using aging-related genes for prognosis in lung adenocarcinoma. | Feng S et al. | — | 2025 | → |
| A Mendelian randomization study between air pollutants and benign prostatic hyperplasia. | Xia L et al. | — | 2025 | → |
| A Mendelian randomization study investigating the causal effect of simvastatin consumption on pancreatitis risk. | Lin W et al. | — | 2025 | → |
| A Mendelian randomization study of the associations between depression, anxiety and clinical conditions including thyroid nodules, flatulence, and irregular menstruation. | Bi Z et al. | — | 2025 | → |
| Analysis of the causal association between systemic lupus erythematosus and osteonecrosis: A bidirectional 2-sample Mendelian randomization study. | Zhang L et al. | — | 2025 | → |
| An atlas on multitudinous risk factors associated with incident hypertension: comprehensive exposome-wide association and wide-angled genetic analyses. | Yang H et al. | — | 2025 | → |
| An Integrated Multi-Omics Analysis Identifies Oxeiptosis-Related Biomarkers in Diabetic Retinopathy. | Deng J et al. | — | 2025 | → |
| An Introduction to Causal Inference Methods with Multi-omics Data. | Yao M et al. | — | 2025 | → |
| A Novel Depression Risk Prediction Model Using NHANES Data With Mendelian Randomization Validation. | Lin L et al. | — | 2025 | → |
| Aortic stenosis intricacies beyond the valve: A bidirectional Mendelian randomization study. | Cai D et al. | — | 2025 | → |
| APM-Related gene signature model to predict prognosis and immunotherapy response in hepatocellular carcinoma. | Zhang S et al. | — | 2025 | → |
| Application of Mendelian Randomization Analysis on the Exploration of the Association Between Immune Cell Phenotypes and Alzheimer's disease. | Guo J et al. | — | 2025 | → |
| Application of Mendelian randomization to explore metabolic pathways in colorectal cancer. | Hoang T et al. | — | 2025 | → |
| A prognostic model for breast cancer survival based on PCD and m6A gene interactions. | Li W et al. | — | 2025 | → |
| A protocol for using human genetic data to identify circulating protein level changes that are the causal consequence of cancer processes. | Hobson LM et al. | — | 2025 | → |
| Are lipid-lowering drugs harmful to cognitive performance?: A Mendelian randomization study. | Han L et al. | — | 2025 | → |
| Arthritis as a risk factor for cataract: Evidence from NHANES data and Mendelian randomization. | Ma M et al. | — | 2025 | → |
| A semi-empirical Bayes approach for calibrating weak instrumental bias in sex-specific Mendelian randomization studies. | Huang YJ et al. | — | 2025 | → |
| A single-cell multi-omics framework identifies immune cell drivers of migraine and repurposable therapeutics. | Li DP et al. | — | 2025 | → |
| Assessing causal associations between TNF-related apoptosis-inducing ligand, vascular endothelial growth factor and colon cancer: a Mendelian-randomization study. | Zhang C et al. | — | 2025 | → |
| Assessing the causal and independent impact of parity-related reproductive factors on risk of breast cancer subtypes. | Prince C et al. | — | 2025 | → |
| Assessing the influence of metabolic syndrome on thyroid cancer: insights from a Mendelian randomization approach. | Ru X et al. | — | 2025 | → |
| Assessing the potential causal influence of myasthenia gravis on neurodegenerative diseases via multivariable Mendelian randomization. | Huang X et al. | — | 2025 | → |
| Assessing the relationship between gut microbiota and hyperprolactinemia: A bidirectional two-sample Mendelian randomization study. | Qi T et al. | — | 2025 | → |
| Assessment of causality between circulating inflammatory proteins and subtypes of diabetic retinopathy. | Dong M et al. | — | 2025 | → |
| Assessment of the bidirectional causal association between frailty and allergic diseases. | Fan GZ et al. | — | 2025 | → |
| Association between 1400 metabolites and IgA nephropathy: A Mendelian randomization analysis. | Wang C et al. | — | 2025 | → |
| Association Between ADHD and Pediatric Asthma: Results From a Large-Sample Cross-Sectional Study of National Surveys and Mendelian Randomization Analyses. | Zhuoran Z et al. | — | 2025 | → |
| Association between anemia and stroke with its subtypes in adults: Insights from NHANES 2005-2016 and Mendelian randomization analyses. | Li Q et al. | — | 2025 | → |
| Association between antibody-mediated immune responses and gastroesophageal reflux disease: Evidence from genetic studies. | Li L et al. | — | 2025 | → |
| Association between antibody-mediated immune responses of herpesvirus and osteoporosis: Mendelian randomization study. | Li B et al. | — | 2025 | → |
| Association between brain connectivity and renal pathophysiology: a multi-trait Mendelian randomization analysis. | Xu Z et al. | — | 2025 | → |
| Association Between Cannabis Use and Neuropsychiatric Disorders: A Two-sample Mendelian Randomization Study. | Guo W et al. | — | 2025 | → |
| Association between childhood obesity and polycystic ovary syndrome: a two-sample Mendelian randomization study. | Wei S et al. | — | 2025 | → |
| Association between chronic kidney disease and colorectal cancer: evidence from meta-analysis and Mendelian randomization. | Qian S et al. | — | 2025 | → |
| Association between chronic kidney disease and depression: evidence from the NHANES 2015-2018 and Mendelian randomization analysis. | Cheng X et al. | — | 2025 | → |
| Association between depression and asthma: insight from observational and genetic evidence. | Ji T et al. | — | 2025 | → |
| Association between different frequencies of age-related hearing loss and depression: A Mendelian randomization and observational study. | Wang W et al. | — | 2025 | → |
| Association between frailty and chest pain: Insights from the 2009 to 2018 NHANES cross-sectional analysis and Mendelian randomization. | Zhang Z et al. | — | 2025 | → |
| Association between glucosamine use and albuminuria in the UK: a cohort and Mendelian randomisation study. | Hayward SJ et al. | — | 2025 | → |
| Association between immune cells and breast cancer: A two-sample Mendelian randomization study. | Luo W et al. | — | 2025 | → |
| Association between ketone metabolism and the risk of depression: An observational and Mendelian randomization study. | Dong X et al. | — | 2025 | → |
| Association between metabolites and hepatocellular carcinoma: findings from a two-sample Mendelian randomization study. | Hoang T et al. | — | 2025 | → |
| Association between mitochondrial DNA copy number and the risk of Parkinson's disease: a meta-analysis and Mendelian randomization study. | Zheng H et al. | — | 2025 | → |
| Association Between Obstructive Sleep Apnea and Prostate Cancer: NHANES and the Mendelian Randomization Study. | Liu Y et al. | — | 2025 | → |
| Association Between Platelet Indices and Risk of Chronic Obstructive Pulmonary Disease: A Bidirectional Mendelian Randomization Study. | Liao W et al. | — | 2025 | → |
| Association Between Preoperative Cognitive Performance and Postoperative Delirium in Older Patients: Results From a Multicenter, Prospective Cohort Study, and a Mendelian Randomization Study. | Sun R et al. | — | 2025 | → |
| Association between rheumatoid arthritis and blood lipid levels: An integrated epidemiological observational analysis and Mendelian randomization study. | Yi J et al. | — | 2025 | → |
| Association Between Serum Apolipoprotein B and Bone Mineral Density and the Effects of Cardiovascular Disease Mediation: Results From the NHANES 2011-2016 and a Mendelian Randomization Study. | Sun A et al. | — | 2025 | → |
| Association between specific neuroticism symptoms and cardiovascular disease: insights from genetic analysis. | Zhang H et al. | — | 2025 | → |
| Association between thyroid function and type 2 diabetes mellitus based on the NHANES and Mendelian randomization study. | Su C et al. | — | 2025 | → |
| Association of antipsychotic drug target genes and risk of lung cancer: a Mendelian randomization study. | Xiang J et al. | — | 2025 | → |
| Association of blood urea nitrogen with gout: Observational and Mendelian randomization analyses. | Hong KD et al. | — | 2025 | → |
| Association of chaperone-mediated autophagy with the mechanisms of vascular calcification in diabetic nephropathy. | Zhang Y et al. | — | 2025 | → |
| Association of circulating fatty acids with metabolic dysfunction-associated steatotic liver disease: A cross-sectional analysis and Mendelian randomization study. | Liu Z et al. | — | 2025 | → |
| Association of educational attainment with mental disorders and the mediation role of lifestyle factors: a Mendelian randomization study. | Shi X et al. | — | 2025 | → |
| Association of female reproductive traits with altered aging trajectories: Insights from genetic and observational analyses. | Lou C et al. | — | 2025 | → |
| Association of Inflammatory Factors and Calcium Metabolism With Arthritis in Patients With Inflammatory Bowel Disease: Evidence From Mediated Mendelian Randomization. | Xiao S et al. | — | 2025 | → |
| Association of Sleep, Inflammation and Female Infertility: A Cross-Sectional Survey and Genetic Approach. | Xin X et al. | — | 2025 | → |
| Association of Vitiligo With Autoimmune Disorders: A Bidirectional Two-Sample and Summary-Based Mendelian Randomization Study. | Huang J et al. | — | 2025 | → |
| Associations between allergic diseases and autoimmune thyroid diseases: A meta-analysis of Mendelian randomization studies. | Li J et al. | — | 2025 | → |
| Associations Between Dietary Factors, Metabolic Factors, Sleep Disorders, Physical Activity, and the Risk of Multiple Sclerosis: A Univariable and Multivariable Mendelian Randomization Study. | Liu H et al. | — | 2025 | → |
| Associations Between Gastroenteropancreatic Neuroendocrine Neoplasms and Inflammatory Factors: Insights From a Two-Sample Mendelian Randomization Analysis. | Guo H et al. | — | 2025 | → |
| Associations between gut microbiota and multiple system atrophy: a Mendelian randomization study. | Wang D et al. | — | 2025 | → |
| Associations Between Obstructive Sleep Apnea and Metabolic Dysfunction-Associated Fatty Liver Disease: Insights from Comprehensive Mendelian Randomization and Gene Expression Analysis. | Ma T et al. | — | 2025 | → |
| Associations Between Single and Multiple Vitamins and the Risk of Dental Caries: Results from a Cross-Sectional Study and Mendelian Randomisation Analysis. | He Q et al. | — | 2025 | → |
| Associations between the gut microbiota, immune cells, and different subtypes of epilepsy: A Mendelian randomization study. | Zhang X et al. | — | 2025 | → |
| Associations of 35 Serum and Urine Biomarkers With Vascular Dementia-A Mendelian Randomization Study. | Zhu X et al. | — | 2025 | → |
| Associations of gestational diabetes mellitus with the risk of cardiometabolic diseases: results from NHANES and mendelian randomization analyses. | Zhang L et al. | — | 2025 | → |
| A Systematic analysis of gut microbiota in anorectal abscess and anal Fistula, with the mediating role of immune cells. | Shen P et al. | — | 2025 | → |
| A two-sample Mendelian randomization analysis of the impact of GABA receptor subtypes on human height. | Chen L et al. | — | 2025 | → |
| A Two-Sample Mendelian Randomization Research Examining the Causal Association Between Ischemic Stroke and Obstructive Sleep Apnea. | Yu Q et al. | — | 2025 | → |
| Bidirectional causal association and shared anti-inflammatory target of asthma and atopic dermatitis: a Mendelian randomization and colocalisation study. | Bi J et al. | — | 2025 | → |
| Bidirectional causality between liver dysfunction and migraine: A mediating Mendelian randomization study. | Yi S et al. | — | 2025 | → |
| Bidirectional causal relationship between depression and Type 2 diabetes: a multi-ancestry and sex stratified Mendelian Randomization analysis. | Liu HY et al. | — | 2025 | → |
| Bidirectional causal relationship between obesity and osteoarthritis: Insights from a two-sample Mendelian randomization study. | Kamps A et al. | — | 2025 | → |
| Bidirectional Mendelian Randomization Analysis of Mood Disorders and Risk of Preeclampsia-Eclampsia. | Zhao C et al. | — | 2025 | → |
| Bidirectional Mendelian Randomization Analysis of the Causal Relationship Between Uterine Fibroids and Breast Cancer in East Asian Women. | Lee Y et al. | — | 2025 | → |
| Bidirectional Mendelian randomization and cross-sectional study reveal depression as a causal risk factor for endometriosis. | Jiang L et al. | — | 2025 | → |
| Bidirectional Mendelian randomization and immune cell mediation analysis: A STROBE-MR study unveiling the causal link between non-small cell and small cell lung cancers. | Gao Y et al. | — | 2025 | → |
| Bidirectional Mendelian Randomization and Multi-Omics Uncover Causal Serum Metabolites and Neuro-Related Mechanistic Pathways in Acute Myeloid Leukemia. | Ye H et al. | — | 2025 | → |
| Bidirectional Mendelian Randomization Indicates Causal Relationships Between Circulating Branched-Chain Amino Acids and Metabolic Health. | Jia RY et al. | — | 2025 | → |
| Birth Weight, Cardiovascular Health, and Microvascular Complications in Individuals with Diabetes Mellitus. | Yu C et al. | — | 2025 | → |
| Blood metabolites and gastric cancer risk: A bidirectional 2-sample Mendelian randomization study. | Chen S et al. | — | 2025 | → |
| Blood Pressure and Mortality in Mexico City: A Mendelian Randomization Study. | Turner M et al. | — | 2025 | → |
| Brain Connectivity Yields Insights into the Pathogenesis of Epilepsy and Subtypes: Evidence from Mendelian Randomization Analysis. | He Z et al. | — | 2025 | → |
| Brain network connectivity and dementia risk: a bidirectional Mendelian randomisation perspective. | Zhu S et al. | — | 2025 | → |
| Breakfast Skipping Increases the Risk of Coronary Heart Disease and Myocardial Infarction: Evidence From the Mendelian Randomization Study. | Cao S et al. | — | 2025 | → |
| Burden and risk factors of autism spectrum disorder: global study and analysis. | Lin L et al. | — | 2025 | → |
| Carnitine and Other Metabolites in Fibromyalgia a Clinical Perspective on a Mendelian Randomization Study. | Hong M et al. | — | 2025 | → |
| Cathepsin Levels and Atrial Fibrillation Risk: Insights From Bidirectional and Multivariable Mendelian Randomization Analyses. | Ye F et al. | — | 2025 | → |
| Cathepsins effect on diffuse large B cell lymphoma risk: A Mendelian randomization study. | Lu C et al. | — | 2025 | → |
| Causal Analysis of Platelet Indices and Breast Cancer, Including Estrogen Receptor-Specific Subtypes: A Mendelian Randomization Study. | Zhu Y et al. | — | 2025 | → |
| Causal and mediating link between sarcopenia and nonalcoholic fatty liver disease: A bidirectional two-sample, two-step Mendelian randomization study. | Li Y et al. | — | 2025 | → |
| Causal association analysis between blood metabolomes and osteopenia and therapeutic target prediction for mechanomedicine. | Liu R et al. | — | 2025 | → |
| Causal association between chronic obstructive pulmonary disease and brain cortical structure: A Mendelian randomization study. | Wang HQ et al. | — | 2025 | → |
| Causal association between circulating Klotho levels and B-cell lymphoma: A 2-sample Mendelian randomization study. | Wang Z et al. | — | 2025 | → |
| Causal association between different types of ametropia and risk of diabetic retinopathy: a two-sample Mendelian randomization study. | Ma Q et al. | — | 2025 | → |
| Causal association between gut microbiota and neonatal digestive system diseases: A Mendelian randomization study. | Pang J et al. | — | 2025 | → |
| Causal association between immunoglobulin G N-glycosylation patterns and diabetic complications: two-sample mendelian randomization. | Zhang X | — | 2025 | → |
| Causal association between insomnia and diabetic nephropathy independent of diabetes: Evidence from 2-sample Mendelian randomization analysis. | Zhang J et al. | — | 2025 | → |
| Causal association between macrophage migration inhibitory factor and nonalcoholic fatty liver disease: A two-sample Mendelian randomization study. | Yu F et al. | — | 2025 | → |
| CAUSAL ASSOCIATION BETWEEN MEDICATION USE AND SEPSIS: A TWO-SAMPLE MENDELIAN RANDOMIZATION STUDY. | Sun M et al. | — | 2025 | → |
| Causal association between neutrophil extracellular traps and rheumatoid arthritis: A 2-sample bidirectional Mendelian randomization study. | Luo J et al. | — | 2025 | → |
| Causal Association Between Psoriasis and Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study. | Lee Y et al. | — | 2025 | → |
| Causal association between rheumatoid arthritis and pancreatic cancer: a bidirectional two-sample Mendelian randomization study. | Li J et al. | — | 2025 | → |
| Causal association between sarcopenia-related traits and osteoarthritis: A bidirectional 2-sample Mendelian randomization Study. | Zhang C et al. | — | 2025 | → |
| Causal association between sleep traits and diabetic nephropathy. | Ji C et al. | — | 2025 | → |
| Causal Association of Alzheimer's Disease with Low Back Pain: A Mendelian Randomization Study. | Li Y et al. | — | 2025 | → |
| Causal association of dietary intake habits and telomere lengths: A Mendelian randomization study. | Chen J et al. | — | 2025 | → |
| Causal Association of Galectins and Diabetic Retinopathy: A Two-Sample Mendelian Randomization Study. | Yang S et al. | — | 2025 | → |
| Causal Associations Between 4907 Circulating Proteins and Hyperlipidemia: A Two-Sample Mendelian Randomization Study Based on European Ancestry. | Cheng H et al. | — | 2025 | → |
| Causal associations between air pollution and breast cancer risk and survival: a Mendelian randomization study. | Li W et al. | — | 2025 | → |
| Causal associations between biomarkers and depression: A Mendelian randomization study. | Guo J et al. | — | 2025 | → |
| Causal Associations Between Body Composition and Cerebral Small Vessel Disease. | Wang M et al. | — | 2025 | → |
| Causal associations between cognitive impairments and retinal diseases: A two-sample Mendelian randomization study. | Shi Q et al. | — | 2025 | → |
| Causal associations between diet and thromboembolism: A 2-sample Mendelian randomization study. | Hu S et al. | — | 2025 | → |
| Causal associations between food intakes and autoimmune skin diseases: A 2-sample Mendelian randomization study. | Xiao T et al. | — | 2025 | → |
| Causal Associations Between Immune Cell Phenotypes and Oral Lichen Planus: A Large-Scale Mendelian Randomization Study. | Meng Z et al. | — | 2025 | → |
| Causal associations between inflammatory cytokines and hypertensive disorders. | Li X et al. | — | 2025 | → |
| Causal associations between insulin-like growth factor binding protein-1 to -7 and osteoporosis: A two-sample Mendelian randomization study. | Du P et al. | — | 2025 | → |
| Causal Associations Between Obstructive Sleep Apnea and Hypertension: Evidence From a Bidirectional and Multivariable Mendelian Randomization Analysis. | Tang S et al. | — | 2025 | → |
| Causal associations between psoriasis and atopic dermatitis: A bidirectional Mendelian randomization study. | Wang Z et al. | — | 2025 | → |
| Causal associations between schizophrenia and other psychiatric disorders: A Mendelian randomization study. | Zhou Y et al. | — | 2025 | → |
| Causal Associations Between Socioeconomic Status, Intelligence, Cognition and Atrial Fibrillation: Evidence From Mendelian Randomization. | Kaisaier W et al. | — | 2025 | → |
| Causal associations of inflammatory proteins and plasma metabolites with Clostridium difficile colitis: A Mendelian randomization study. | Dong G et al. | — | 2025 | → |
| Causal associations of single anthropometric measures and body shape with nonalcoholic fatty liver disease: A Mendelian randomization study. | Zhai C et al. | — | 2025 | → |
| Causal Associations of the Alterations in Peripheral Blood Immune Cell Characteristics on the Incidence of Osteoporosis: A Bidirectional Mendelian Randomization Study. | Yin Q et al. | — | 2025 | → |
| Causal correlation between gut microbiota and stable angina pectoris: a two-sample Mendelian randomisation study. | Zhou C et al. | — | 2025 | → |
| Causal Effect of Blood Cell Perturbation Phenotypes on Multiple Sclerosis via Immune Mediation: A Mendelian Randomization Study. | Yun JJ et al. | — | 2025 | → |
| Causal effect of body mass index on herpes zoster and postherpetic neuralgia: A Mendelian randomization study. | Wang W et al. | — | 2025 | → |
| Causal effect of gut microbiota and its metabolites on cerebral small vessel disease: A multivariable Mendelian randomization analysis. | Xue H et al. | — | 2025 | → |
| Causal effect of kimchi intake on HDL-cholesterol levels in middle aged Korean men: a two-sample Mendelian randomization analysis. | Cha J et al. | — | 2025 | → |
| Causal Effect of Plasma Fatty Acid Profiles on Psoriasis Risk: Genetic Evidence from a Mendelian Randomization Study. | Yao L et al. | — | 2025 | → |
| Causal effects and immune cells mediators between gut microbiota and sicca syndrome: A Mendelian randomization study. | Yue J et al. | — | 2025 | → |
| Causal effects and metabolite mediation of immune cells in preterm birth: a Mendelian randomization study. | Zhou T et al. | — | 2025 | → |
| Causal effects of antibody-mediated immune responses on allergic diseases: A bidirectional Mendelian randomization study. | Leng L et al. | — | 2025 | → |
| Causal effects of body composition on lifespan: Mendelian randomization analysis. | Jiesisibieke ZL et al. | — | 2025 | → |
| Causal Effects of Breast Cancer Risk Factors across Hormone Receptor Breast Cancer Subtypes: A Two-Sample Mendelian Randomization Study. | Verdiesen RMG et al. | — | 2025 | → |
| Causal effects of cholecystectomy on the lipidome: cross-sectional and mendelian randomization studies. | Liang Y et al. | — | 2025 | → |
| Causal effects of dietary antioxidants on epigenetic age: A two-sample Mendelian randomization study. | Huang C et al. | — | 2025 | → |
| Causal effects of immune cell populations on biological aging: a Mendelian randomization study. | Fu J et al. | — | 2025 | → |
| Causal Effects of Immune Cell Populations on Cognitive Performance: A Mendelian Randomization Study. | Fu J et al. | — | 2025 | → |
| Causal Effects of Immune Cells on Reproductive Ill-Health, Including Abnormal Spermatozoa, Polycystic Ovary Syndrome and Spontaneous Abortion: Mendelian Randomization Analyses. | Chen S et al. | — | 2025 | → |
| Causal Effects of Inflammatory Arthritis Subtypes on Fibromyalgia: A Comprehensive Mendelian Randomization Study. | Wang F et al. | — | 2025 | → |
| Causal Effects of Inflammatory Bowel Disease on Lung Function and Disease: A Two-Sample Mendelian Randomization Study. | Fu X et al. | — | 2025 | → |
| Causal Effects of Metabolic Syndrome on Gastric Disorders: Univariable and Multivariable Mendelian Randomization. | Li B et al. | — | 2025 | → |
| Causal effects of physical activity and screen time on childhood intelligence via Mendelian randomization: The mediating role of intracranial volume. | Feng J et al. | — | 2025 | → |
| Causal Effects of Plasma Proteins in Polycystic Ovary Syndrome: A Proteome-Wide Mendelian Randomization Study. | Yu T et al. | — | 2025 | → |
| Causal effects of primary aldosteronism on inflammation and bone density: evidence from Mendelian randomization, animal, and clinical studies. | Zhang Z et al. | — | 2025 | → |
| Causal effects of the gut microbiota, circulating metabolites, and cardiometabolic diseases: A Mendelian randomization study. | Ye C et al. | — | 2025 | → |
| Causal Gene Identification and Biomarker Prioritization in Periodontitis via Integrative Multiomics and Mendelian Randomization. | Mo H et al. | — | 2025 | → |
| Causal genetic link between gut microbiome, metabolites, and autism spectrum disorder in a European cohort. | Chen C et al. | — | 2025 | → |
| Causal impact of obesity class stratification and endometrial cancer subtypes: an integrated Mendelian randomization and Global Burden of Disease Study 2021 analysis. | Tong Y et al. | — | 2025 | → |
| Causal inference study on the effect of exogenous insulin on the risk of osteoarthritis. | Zheng J et al. | — | 2025 | → |
| Causal insights into immune cell profiles, plasma metabolites, and bladder cancer: A Mendelian randomization approach. | Yang J et al. | — | 2025 | → |
| Causality between aging and interstitial lung disease: A bidirectional two-sample Mendelian randomization study. | Luo W et al. | — | 2025 | → |
| Causality between periodontitis and schizophrenia, bipolar disorder, and major depressive disorder: A mendelian randomization study. | Zhang S et al. | — | 2025 | → |
| Causality between rheumatic diseases and iron-deficiency anemia: A 2-sample, 2-step mediation Mendelian randomization investigation. | Huang W et al. | — | 2025 | → |
| Causality of blood metabolites and narcolepsy type 1: A Mendelian randomization study. | Shen B et al. | — | 2025 | → |
| Causality of genetically determined gut microbiota on lung cancer: a Mendelian randomization study. | Yu H et al. | — | 2025 | → |
| Causal link between coronary heart disease and lipidomics: A Mendelian randomization analysis. | Kang R et al. | — | 2025 | → |
| Causal Link Between Thyroid Function and Female-Specific Cancers: A Bidirectional Two-Sample and Mediation Mendelian Randomization Study. | Gao B et al. | — | 2025 | → |
| Causal Link of Distinct Mental Disorders with Androgenetic Alopecia and Alopecia Areata: A Bidirectional Two-Sample Mendelian Randomization Study. | Hu C et al. | — | 2025 | → |
| Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study. | Zhao J et al. | — | 2025 | → |
| Causal relationship and shared genetic pathways between diabetic kidney disease and cognitive impairment: a Mendelian randomization study. | Yu K et al. | — | 2025 | → |
| Causal relationship between 179 plasma lipids and intracranial aneurysm: A 2-sample Mendelian randomization study. | Ding L et al. | — | 2025 | → |
| Causal relationship between 91 circulating inflammatory proteins and gynecological diseases: A two-sample bidirectional Mendelian randomization study. | Wang JL et al. | — | 2025 | → |
| Causal relationship between air pollution and rheumatoid arthritis: A two-sample Mendelian randomization study. | Yang C et al. | — | 2025 | → |
| Causal relationship between albumin, total protein, and colorectal cancer risk: A 2-sample Mendelian randomization study. | Chen J et al. | — | 2025 | → |
| Causal relationship between Alzheimer's disease and cerebral small vessel disease: a Mendelian randomization study. | Liu R et al. | — | 2025 | → |
| Causal Relationship Between Anxiety Disorders and Cancers: A Bidirectional Two-Sample Mendelian Randomization Study. | Su J et al. | — | 2025 | → |
| Causal relationship between asthma and chronic rhinosinusitis: A Mendelian randomization study. | Li J et al. | — | 2025 | → |
| Causal Relationship Between Brain Functional Networks and Sleep Disorders: A Mendelian Randomization Study. | Lin W et al. | — | 2025 | → |
| Causal relationship between branched-chain amino acids and their metabolites and frailty: A two-sample Mendelian randomization study. | Zhou Y et al. | — | 2025 | → |
| Causal Relationship Between Butyrate and Dyspepsia: Evidence From Two-Sample Mendelian Randomization Analysis of CSF Metabolites. | Cai Y et al. | — | 2025 | → |
| Causal relationship between cardiovascular diseases and vestibular dysfunction: A 2-sample Mendelian randomization study. | Liu H et al. | — | 2025 | → |
| Causal Relationship Between Cataracts and Gastrointestinal Diseases: A Two-Sample Mendelian Randomization Study. | Li Y et al. | — | 2025 | → |
| Causal relationship between chronic hepatitis B infection and gastric ulcer: A Mendelian randomization study. | Wang Y et al. | — | 2025 | → |
| Causal relationship between circulating immune cells and diabetic nephropathy: A Mendelian randomization study. | Wang T et al. | — | 2025 | → |
| Causal relationship between circulating micronutrient levels and bipolar disorder: A Mendelian randomization study. | You T et al. | — | 2025 | → |
| Causal Relationship Between Circulating Omega-3 Fatty Acid and Cerebral Small Vessel Disease: A Mendelian Randomization Study. | Zhang Y et al. | — | 2025 | → |
| Causal Relationship Between Depression, Sleep Disorders, and Constipation: A Mendelian Randomization and Mediation Analysis. | Wang JX et al. | — | 2025 | → |
| Causal relationship between dietary factors and oral mucosal lesions: Two-sample Mendelian randomization analysis. | Jiang S et al. | — | 2025 | → |
| Causal Relationship Between Galectins With Neuroblastoma: A Mendelian Randomization Study. | Long C et al. | — | 2025 | → |
| Causal Relationship Between Genetically Determined Free Fatty Acids and Nonalcoholic Fatty Liver Disease: A Mendelian Randomization Study. | Li K et al. | — | 2025 | → |
| Causal relationship between gut microbiota and diabetic neuropathy: a Mendelian randomization and 16S rRNA sequencing analysis. | Hu Y et al. | — | 2025 | → |
| Causal Relationship between Gut Microbiota and Endometrial Cancer: A Two-Sample Mendelian Randomization Study. | Yao X et al. | — | 2025 | → |
| Causal relationship between gut microbiota and pituitary neuroendocrine tumors: a bidirectional Mendelian randomization. | Wang W et al. | — | 2025 | → |
| Causal relationship between gut microbiota and pneumonia: a Mendelian randomization and retrospective case-control study. | Huang P et al. | — | 2025 | → |
| [Causal relationship between gut microbiota and T cell subsets in the development of colorectal cancer: a Mendelian randomization analysis]. | Yu Z et al. | — | 2025 | → |
| Causal relationship between hypertension and cancer: a two‑sample bidirectional Mendelian randomization study. | Zeng C et al. | — | 2025 | → |
| Causal relationship between IgG N-glycosylation and autoimmune thyroid diseases, and the possible mediating role of immune cells and inflammatory cytokines. | Li W et al. | — | 2025 | → |
| Causal relationship between immune cells and myocardial infarction: A Mendelian randomization study. | Xu Y et al. | — | 2025 | → |
| Causal Relationship between Immune Cells and Postpartum Depression: A Bidirectional Two-Sample Mendelian Randomization Study. | Zhu Y et al. | — | 2025 | → |
| Causal relationship between inflammatory bowel disease and cardiovascular disease: a two-sample Mendelian randomized study. | Ma L et al. | — | 2025 | → |
| Causal Relationship Between Inflammatory Bowel Disease and Neuropsychiatric Disorders: A Bidirectional Mendelian Randomization Study. | Lei J et al. | — | 2025 | → |
| Causal Relationship Between Matrix Metalloproteinase and Cervical Lesions: A Two-Sample Mendelian Randomization Analysis. | Pan M et al. | — | 2025 | → |
| Causal Relationship Between Matrix Metalloproteinase with Their Tissue Inhibitors and Human Immunodeficiency Virus Infection: A Two-Sample Bidirectional Mendelian Randomization Analysis. | Guo C et al. | — | 2025 | → |
| Causal relationship between multiple types of food intake and myopia: a Mendelian randomization study. | Zhang SS et al. | — | 2025 | → |
| Causal relationship between oral/gut microbiota and lung cancer: a two-sample Mendelian randomization study. | Huang ZJ et al. | — | 2025 | → |
| Causal relationship between plasma lipidome and 6 types of cancer: A Mendelian randomization study. | Tang N et al. | — | 2025 | → |
| Causal relationship between plasma metabolites and hypertension: A Mendelian randomization study. | Yang F et al. | — | 2025 | → |
| Causal relationship between proton pump inhibitors and dementia risk: evidence from a Mendelian randomization study. | Ou M et al. | — | 2025 | → |
| Causal relationship between schizophrenia and tachyarrhythmia: A Mendelian randomization study based on a European population. | Li P et al. | — | 2025 | → |
| Causal relationship between serum metabolites and chronic myeloid leukemia: A bidirectional Mendelian randomization study. | Ye H et al. | — | 2025 | → |
| Causal Relationship Between Serum Uric Acid and Atherosclerotic Disease: A Mendelian Randomization and Transcriptomic Analysis. | Wang S et al. | — | 2025 | → |
| Causal Relationship Between Sleep Characteristics and Alopecia Areata and Other Non-Scarring Alopecia: A Two-Sample Bidirectional Mendelian Randomization Analysis. | Li Y et al. | — | 2025 | → |
| Causal relationship between statins and hemorrhagic stroke: A drug-target Mendelian randomization analysis. | Xia M et al. | — | 2025 | → |
| Causal relationship between systolic blood pressure and susceptibility to allergic rhinitis in East Asian populations: A bidirectional two-sample Mendelian randomization study. | Fan J et al. | — | 2025 | → |
| Causal relationship between the plasma lipidome and urological cancers: A two-sample Mendelian randomization study. | Chen R et al. | — | 2025 | → |
| Causal Relationship Between Type 2 Diabetes Mellitus and Preeclampsia: A Bidirectional Two-Sample Mendelian Randomized Study. | Song X et al. | — | 2025 | → |
| Causal relationship between varicose veins and hydrocele: A bidirectional two-sample Mendelian randomization study. | Guo C et al. | — | 2025 | → |
| Causal relationship between white matter structural connectivity and epilepsy. | Zhang N et al. | — | 2025 | → |
| Causal relationships between 4907 circulating proteins and heart failure and atrial fibrillation: A bidirectional Mendelian randomization study. | Yang Z et al. | — | 2025 | → |
| Causal Relationships Between Abdominal Obesity, Type 2 Diabetes, Fasting Insulin, and Cervical Disc Disorders, Osteoporosis, and Rheumatoid Arthritis: A Mendelian Randomization Study. | Tang H et al. | — | 2025 | → |
| Causal relationships between antibody-mediated immune responses and acute pancreatitis: Evidence from a genetic study. | Xie M et al. | — | 2025 | → |
| Causal relationships between gut microbiome and hundreds of age-related traits: evidence of a replicable effect on ApoM protein levels. | Grosso F et al. | — | 2025 | → |
| Causal relationships between immune cells and common urinary system tumors: A bidirectional analysis of Mendelian randomization. | Liu Z et al. | — | 2025 | → |
| Causal Relationships Between Immune Cell Traits, Plasma Metabolites, and Asthma: A Two-Step, Two-Sample Mendelian Randomization Study. | Hu Z et al. | — | 2025 | → |
| Causal relationships between metabolic syndrome, plasma metabolites, and female reproductive diseases: insights from a two-step mendelian randomization approach. | Li L et al. | — | 2025 | → |
| Causal relationships between micronutrients and sarcopenia: a two-sample bidirectional Mendelian randomization study. | Liu H et al. | — | 2025 | → |
| Causal relationships between neuroimaging phenotypes and the risk of early and late-onset alzheimer's disease. | Zhou J et al. | — | 2025 | → |
| Causal relationships between plasma proteins and Alzheimer's disease using bidirectional Mendelian randomization. | Li Y et al. | — | 2025 | → |
| Causal Relationships Between Pregnancy, Menstrual History, and Endometrial Cancer With Mediating Effects of Metabolism-Related Traits. | Zhou M et al. | — | 2025 | → |
| Causal Relationships Between the Oral Microbiome and Autoimmune Diseases: A Mendelian Randomization Study. | Wu X et al. | — | 2025 | → |
| Causal relationships between white matter connectome and mental disorders: a large-scale genetic correlation study. | Zhao Z et al. | — | 2025 | → |
| Causal relationships of serum iron metabolites with sepsis and cardiomyopathy: a Mendelian randomization analysis. | Zhang J et al. | — | 2025 | → |
| Causal role of phenylalanine and cholesterol metabolism in bladder cancer Chemoresistance: Insights from mendelian randomization and targeted molecular docking. | Li J et al. | — | 2025 | → |
| Causal role of the plasma lipidome in the occurrence and progression of chronic kidney disease: a two-sample Mendelian randomization study. | Su J et al. | — | 2025 | → |
| Causal validation between 179 lipids and hyperparathyroidism: A bidirectional Mendelian randomization combined meta-analysis with mediation factors. | Zhu C et al. | — | 2025 | → |
| CD45 on CD33br HLA-DR+ immune cells promote cholecystitis via glycine-mediated pathways: A Mendelian randomization study. | Zeng X et al. | — | 2025 | → |
| Cerebrospinal fluid haptoglobin levels and outcome after aneurysmal subarachnoid haemorrhage: Evidence from Mendelian randomization. | Kayode GA et al. | — | 2025 | → |
| Cerebrospinal fluid metabolomic and postpartum depression: A Mendelian randomization study. | Hong M et al. | — | 2025 | → |
| Characterizing aging-related genetic and physiological determinants of spinal curvature. | Wang FM et al. | — | 2025 | → |
| Childhood obesity influences mid-to-late life bone health through shared genetic architecture. | Xia M et al. | — | 2025 | → |
| Cholecystitis and cholangiocarcinoma: a two-sample Mendelian randomization study. | Gao X et al. | — | 2025 | → |
| Cigarette smoke-induced lung-brain barrier dysfunction drives neurocognitive impairment via inflammatory spill-over. | Yu X et al. | — | 2025 | → |
| Circulating causal protein networks linked to future risk of myocardial infarction. | Bankier S et al. | — | 2025 | → |
| Circulating Inflammatory Cytokines, Lipoprotein Particles, and Gestational Diabetes Risk: A Mendelian Randomization Study. | Xu J et al. | — | 2025 | → |
| Circulating inflammatory proteins as causal drivers and therapeutic targets in asthma: insights from genetic and pathway-based analyses. | Miao Y et al. | — | 2025 | → |
| Circulating Inflammatory Proteins Mediate the Causal Effect of Gut Microbiota on Inflammatory Bowel Disease: Bayesian and Mediated Mendelian Randomization. | Li Z et al. | — | 2025 | → |
| Clonal hematopoiesis of indeterminate potential as a risk factor for atrial fibrillation: Evidence of a causal relationship by Mendelian randomization study. | Zhang Q et al. | — | 2025 | → |
| Combined Analysis of Transcriptome and Mendelian Randomization Reveals <i>AKT1</i> and <i>PPARG</i> as Biomarkers Related to Glucose Metabolism in Sepsis. | Ma J et al. | — | 2025 | → |
| Common sleep characteristics and the risk of common perinatal complications and adverse outcomes: a multi-sample, bidirectional Mendelian randomization study. | Wang N et al. | — | 2025 | → |
| Community-based causal evidence that high habitual caffeine consumption alters distinct polysomnography-derived sleep variables. | Stucky B et al. | — | 2025 | → |
| Complex causal association between immune cells and psoriatic arthritis: A bidirectional Mendelian randomization study. | Jia Y et al. | — | 2025 | → |
| Comprehensive Analysis Reveals Biomarkers Related to Diabetic Peripheral Neuropathy and Its Molecular Mechanism. | Zhu Q et al. | — | 2025 | → |
| Constipation and Parkinson disease: A 2-sample bidirectional Mendelian randomization analysis. | Li H et al. | — | 2025 | → |
| Correlations between genetically predicted iron-supplement drug targets and inflammatory bowel disease: A Mendelian randomization study. | Li DL et al. | — | 2025 | → |
| COVID-19, inflammatory cytokines, and digestive system cancers: a bidirectional Mendelian study and mediation analysis. | Liang Y et al. | — | 2025 | → |
| COVID-19 vaccination status and the risk of developing lung diseases: A Mendelian randomization study. | Niu D et al. | — | 2025 | → |
| C-reactive protein and prospective cardiometabolic risk: observational and Mendelian randomization study of ischemic stroke and all-cause death. | Rolver MG et al. | — | 2025 | → |
| Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation. | Yuan S et al. | — | 2025 | → |
| Deciphering causality between social/physical activity and suicide attempt: evidence from Mendelian randomization. | Li H et al. | — | 2025 | → |
| Deciphering the causal relationships between plasma metabolites, peripheral cells, inflammatory factors and DLBCL for discovering novel therapeutic targets. | Xu M et al. | — | 2025 | → |
| Deciphering the genetic interconnection between sarcopenia and osteoporosis: SCD1. | Lv Y et al. | — | 2025 | → |
| Deciphering the immunometabolic axis: a mendelian randomization study of a causal cascade network from immune cell phenotypes to metabolites in esophageal cancer. | Gui D et al. | — | 2025 | → |
| Deciphering the role of cathepsins in digestive system cancers: a Mendelian randomization study. | Guo B et al. | — | 2025 | → |
| Decoding rheumatoid arthritis: Biomarker identification and immune profiling via bioinformatics and Mendelian randomization. | Shao S et al. | — | 2025 | → |
| Decoding the skin microbiota: A Mendelian randomization study reveals new insights into acne causality. | Zhou J et al. | — | 2025 | → |
| Detecting a potential causal relationship between plasma metabolites and myocardial infarction using bidirectional and two-step Mendelian randomization. | Yang M et al. | — | 2025 | → |
| Development and validation of a prognostic prediction model for gastric cancer based on lipophagy-related genes. | Wusiman L et al. | — | 2025 | → |
| Diabetes is associated with a decreased risk of meningiomas: a mendelian randomization study. | Wang R et al. | — | 2025 | → |
| Dietary factors causally affect the risk of kidney cancer: a two-sample Mendelian randomization study. | Zhu C et al. | — | 2025 | → |
| Dietary intake and five types of mental disorders: a bidirectional Mendelian randomization study. | Zhang Y et al. | — | 2025 | → |
| Dietary patterns, physical activity, and risk of urinary tract diseases: a two sample Mendelian randomization analysis. | Zhao C et al. | — | 2025 | → |
| Dietary Sodium-Potassium Imbalance and Hypertension: Causal Pathways Involving Gut Microbiota Dysbiosis, Inflammation, and Metabolic Disorders. | Lu C et al. | — | 2025 | → |
| Differential association of platelet indices in NAFLD/NASH: a Mendelian randomized study. | Huang H et al. | — | 2025 | → |
| Differential Causal Effects of Common Analgesics on Breast Cancer Risk and Survival: Evidence from Mendelian Randomization. | Peng Z et al. | — | 2025 | → |
| Disentangling horizontal and vertical Pleiotropy in genetic correlation estimation: introducing the HVP model. | Amente LD et al. | — | 2025 | → |
| Disentangling the Causal Effects of Education and Participation Bias on Alzheimer Disease Using Mendelian Randomization. | Chatterjee A et al. | — | 2025 | → |
| Disentangling the divergent causal pathways underlying the association between body mass index and bone mineral density: a comprehensive Mendelian randomization study. | Zhao X et al. | — | 2025 | → |
| Disentangling the genetic relationship between malignant skin neoplasms and sepsis: Evidence from bidirectional Mendelian randomization. | Liu Q et al. | — | 2025 | → |
| Dissecting causal networks of inflammatory factors and metabolites in heart failure: A mediation Mendelian randomization study. | Guan X et al. | — | 2025 | → |
| Dissecting causal relationships between dietary factors and intracerebral hemorrhage: A Mendelian randomization study. | Wang P et al. | — | 2025 | → |
| Dissecting Causal Relationships Between Gut Microbiota Imbalance, Inflammatory Cytokines, and Structural Connectivity in the Brain: A Mendelian Randomization Study. | Guo Q et al. | — | 2025 | → |
| Dissecting Causal Relationships Between Gut Microbiota, Immunocyte Phenotype, and Migraine: A Mendelian Randomization Study. | Lai Y et al. | — | 2025 | → |
| Dissecting Causal Relationships Between Gut Microbiota, Plasma Metabolites and Bladder Cancer: A Two-Step Mendelian Randomization Study. | Che K et al. | — | 2025 | → |
| Dissecting the causal effects of interleukin receptor-related factors and the risk of developing endometriosis: a two-sample Mendelian randomization study. | Lv SJ et al. | — | 2025 | → |
| Dissecting the role of plasma and urinary metabolites in bone mineral density: Evidence from a bidirectional univariable Mendelian randomization study. | Xie T et al. | — | 2025 | → |
| Distinct gut microbiota profiles in acute vs. chronic sinusitis: potential biomarkers. | Cao H et al. | — | 2025 | → |
| DNA methylation and bronchiectasis: a Mendelian randomization analysis to investigate causal link and therapeutic target. | Qin J et al. | — | 2025 | → |
| DNA methylation-mediated ADA overexpression drives pancreatic cancer progression. | Zeng J et al. | — | 2025 | → |
| DNA methylation regulates TREM1 expression to modulate immune responses and drive progression in colorectal neuroendocrine neoplasm as a potential therapeutic target. | Guo H et al. | — | 2025 | → |
| Does uveitis increase the risk of age-related wet macular degeneration? A Mendelian randomization study. | Jing RH et al. | — | 2025 | → |
| Druggable Genome Mendelian Randomization and GWAS-sceQTLs MR Analysis Reveal Genetic Associations Between Open-Angle Glaucoma and Immune Cells, and Identify Potential Drugs. | Ke K et al. | — | 2025 | → |
| Dynamics of mitochondrial DNA copy number regulation in relation to gastric cancer survival. | Yang Q et al. | — | 2025 | → |
| Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences. | Beeche C et al. | — | 2025 | → |
| Effect of education on endometriosis and mediating effects: a mendelian randomization study. | Jin L et al. | — | 2025 | → |
| Effect of the gut microbiota on frozen shoulder and potential mediating role of inflammatory cytokines: A Mendelian randomization study and mediation analysis. | Feng Z et al. | — | 2025 | → |
| Effects of Diabetes Mellitus and Glycemic Traits on COPD and Pulmonary Function Traits: Insights From Mendelian Randomization and NHANES. | Wang N et al. | — | 2025 | → |
| Effects of PD-1 inhibitors on ovarian function-based on two-sample mendelian randomization and visualization experimental validation. | Zheng J et al. | — | 2025 | → |
| Efficient Mendelian randomization analysis with self-adaptive determination of sample structure and multiple pleiotropic effects. | Zhang L et al. | — | 2025 | → |
| Elevated CD14 in B cells associates with reduced ovarian cancer risk via CD80 + dendritic cell interaction: a multi-omics study. | Zheng M | — | 2025 | → |
| Elevated interleukin-12B is associated with increased seizure susceptibility: insights from two-sample Mendelian randomization and <i>in vivo</i> experiment. | Lu Y et al. | — | 2025 | → |
| Elevated Ocular and Visual Disorder Risk in Developmental Disabilities: Insights from Cross-Sectional Study and Mendelian Randomization Analysis. | Li X et al. | — | 2025 | → |
| Elucidating causal relationships between circulating inflammatory factors and aging traits: Transcriptomics and Mendelian randomization analyses. | Cao D et al. | — | 2025 | → |
| Elucidating the causal role of age of menarche, adiposity, lipid fractions, and blood pressure upon cardiovascular disease: a multivariable Mendelian randomization study. | Jee Y et al. | — | 2025 | → |
| Elucidating the causal triad of cardiovascular disease, cancer, and lipid traits: a bidirectional Mendelian randomization study with genetic mediation analysis. | Wu W et al. | — | 2025 | → |
| Elucidating the genetic and metabolomic underpinnings of age-related macular degeneration through two-sample Mendelian randomization. | Shen W et al. | — | 2025 | → |
| Endometriosis and Ovarian Cancer: Insights from NHANES and Mendelian Randomization Analysis. | Liu D et al. | — | 2025 | → |
| Entertainment activities and the risk of multiple sclerosis: A Mendelian randomization analysis. | Wang Z et al. | — | 2025 | → |
| Epigenetic age acceleration and allergic diseases: a bidirectional two-sample Mendelian randomization study. | Sun J et al. | — | 2025 | → |
| Epigenetic age acceleration and midlife cognition: joint evidence from observational study and Mendelian randomization. | Pan Y et al. | — | 2025 | → |
| Epigenetic Mediating Mechanisms in Parkinson's Disease: The Impact of Educational Attainment on SETD1A Expression. | Yin KF et al. | — | 2025 | → |
| Epilepsy and migraine: A bidirectional mendelian randomization study. | Chen F et al. | — | 2025 | → |
| Estimating effects of serum vitamin B12 levels on psychiatric disorders and cognitive impairment: a Mendelian randomization study. | Lu T et al. | — | 2025 | → |
| Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders. | Gilchrist L et al. | — | 2025 | → |
| Evaluating the effect of metformin on sarcopenia: A Mendelian randomization study. | Fan C et al. | — | 2025 | → |
| Evaluating the relationship between educational attainment, obesity-related indicators, and prostate diseases: A univariable and multivariable Mendelian randomization study. | Ji WT et al. | — | 2025 | → |
| Evaluating transportability of in vitro cellular models to in vivo human phenotypes using gene perturbation data. | Howe LJ et al. | — | 2025 | → |
| Evidence of bidirectional relationship between type 2 diabetes and depression; a Mendelian randomization study. | Bala R et al. | — | 2025 | → |
| Exploration and Validation of Key Genes and Immune Infiltration in Alcoholic Hepatitis. | Mei Y et al. | — | 2025 | → |
| Exploration and validation of the prognostic value of mitophagy and mitochondrial dynamics-related genes in cervical cancer. | Li J et al. | — | 2025 | → |
| Exploration of causal relationship between transplant rejection and immune cells: A two-sample Mendelian randomization study. | Xue F et al. | — | 2025 | → |
| Exploration of potential novel drug targets for rheumatoid arthritis by plasma proteome screening. | Ma Z et al. | — | 2025 | → |
| Exploration of potential therapeutic target genes for preeclampsia through genetic analysis. | Wang H et al. | — | 2025 | → |
| Exploring Bidirectional Causality between Obstructive Sleep Apnea and Chronic Kidney Disease via Mendelian Randomization. | Liu X et al. | — | 2025 | → |
| Exploring causal associations between nuclear magnetic resonance biomarkers and colorectal cancer risk. | Zhou Q et al. | — | 2025 | → |
| Exploring Causality Between Bone Mineral Density and Cervical Spondylosis: Bidirectional and Multivariable Mendelian Randomization Study. | Mao W et al. | — | 2025 | → |
| Exploring causal link of 25-hydroxyvitamin D with eating disorder risk via bidirectional Mendelian randomization. | Zhang H et al. | — | 2025 | → |
| Exploring Causal Relationships Between Kidney Function and the Risk of Senile Cataract and Primary Open-Angle Glaucoma: A Mendelian Randomization Study and Bioinformatics Analyses. | Li P et al. | — | 2025 | → |
| Exploring genetic association of chronic kidney disease with sarcopenia among European population: a bidirectional Mendelian randomization study. | Zhu X et al. | — | 2025 | → |
| Exploring metabolic pathways in gastrointestinal cancer: new evidence of causality. | Wang Z et al. | — | 2025 | → |
| Exploring of bladder cancer immune-related genes and potential therapeutic targets based on transcriptomic data and Mendelian randomization analysis. | Xu Z et al. | — | 2025 | → |
| Exploring Potential Causal Links: How Parkinson's Disease Brain Damage Impacts Liver Health-A Mendelian Randomization and Transcriptomic Study. | Liu T et al. | — | 2025 | → |
| Exploring the Association between Childhood Intelligence and Vestibular Function: A Mendelian Randomization Study. | Zhong A et al. | — | 2025 | → |
| Exploring the Association Between Multidimensional Dietary Patterns and Non-Scarring Hair Loss Using Mendelian Randomization. | Pan L et al. | — | 2025 | → |
| Exploring the Causal Association Between 91 Circulating Inflammatory Proteins and Neurodegenerative Diseases: A Bidirectional Two-Sample Mendelian Randomization and Bioinformatics Analysis. | Gong Z et al. | — | 2025 | → |
| Exploring the causal effects of epilepsy and its subtypes on anthropometric traits: A 2-sample Mendelian randomization study. | Chen L et al. | — | 2025 | → |
| Exploring the Causal Links Between 338 Cerebrospinal Fluid Metabolites and Parkinson's Disease. | Zhang H et al. | — | 2025 | → |
| Exploring the causal relationship between acute respiratory distress syndrome and gut microbiota: Unveiling the gut-lung axis through a large-scale Mendelian randomization study. | Li C et al. | — | 2025 | → |
| Exploring the causal relationship between gut microbiota, circulating inflammatory proteins, and colorectal neuroendocrine tumors: a Mendelian randomization study. | Cui J et al. | — | 2025 | → |
| Exploring the causal relationship between immune cell characteristics and melanoma: A two-way Mendelian randomization study. | Wang S et al. | — | 2025 | → |
| Exploring the causal relationship between plasma proteins and postherpetic neuralgia: a Mendelian randomization study. | Wei Q et al. | — | 2025 | → |
| Exploring the causal role of gut microbiota and inflammatory proteins in neuromyelitis optica spectrum disorder: A Mendelian randomization study with mediation analysis. | Yin Z et al. | — | 2025 | → |
| Exploring the complex relationship between systemic lupus erythematosus and coronavirus disease 2019: genetic insights and potential protective mechanisms. | Xu X et al. | — | 2025 | → |
| Exploring the genetic causality of childhood maltreatment on multiple risk-related outcomes using Mendelian randomization: evidence from European-Ancestry GWAS. | Zhang Z et al. | — | 2025 | → |
| Exploring the genetic determinants of the oral microbiome's role in gastrointestinal cancer risk: Mendelian randomization and genetic correlation analysis in an East Asian population. | Jin W et al. | — | 2025 | → |
| Exploring the impact of physical activity and micronutrients on diabetic nephropathy: a subtype-specific genetic correlation and Mendelian randomization study. | Li F et al. | — | 2025 | → |
| Exploring the liver-brain axes: insights from a bidirectional Mendelian randomization study on brain cortical structure and liver cancers. | Zhu Q et al. | — | 2025 | → |
| Exploring the pathways linking fasting insulin to coronary artery disease: a proteome-wide Mendelian randomization study. | Huang X et al. | — | 2025 | → |
| Exploring the plausible genetic relationship of salivary and tongue microbiome with periodontitis: A mendelian randomization study. | Li J et al. | — | 2025 | → |
| Exploring the Protein-Metabolite Interplay to Discover Novel Drug Targets for Alzheimer's Disease. | Yin KF et al. | — | 2025 | → |
| Exploring the relationship between graft dysfunction with serum metabolites and inflammatory proteins: integrating Mendelian randomization, single-cell analysis, machine learning, and SHAP methods for comprehensive analysis. | Li J et al. | — | 2025 | → |
| Exploring the relationship between metabolic syndrome and vestibular dysfunction: NHANES data and Mendelian randomization analysis. | Zhang L et al. | — | 2025 | → |
| Exploring the role of 338 cerebrospinal fluid metabolites in primary brain malignancies risk: a Mendelian randomization study. | He H et al. | — | 2025 | → |
| Exploring the Role of B-Cell Biotherapy in Myasthenia Gravis from a Genetic Perspective: A Mendelian Randomization Study. | Zhang M et al. | — | 2025 | → |
| Exploring the Role of Immune Cells in Glioma: Causal Associations and Clinical Implications. | Pan Y et al. | — | 2025 | → |
| Exploring the role of immune cell traits and circulating inflammatory cytokines in the development of diabetic neuropathy. | Guo N et al. | — | 2025 | → |
| Exploring the role of inflammation, immunity, and metabolism in colorectal cancer via mendelian randomization approach. | Zhou L et al. | — | 2025 | → |
| Exploring the Shared Genetic Architectures Between Primary Open-Angle Glaucoma and Visual Pathway Regions in the Brain. | Aman AM et al. | — | 2025 | → |
| Exploring the Therapeutic Potential of Antidiabetic Drugs in Cardiac Arrhythmia Management: A Drug Target Mendelian Randomization Study. | Song ZQ et al. | — | 2025 | → |
| Extreme exercise in males is linked to mTOR signalling and onset of amyotrophic lateral sclerosis. | O'Brien D et al. | — | 2025 | → |
| From genetic causality to druggable targets: A multiomics framework identifies ZSCAN16 in gout pathogenesis. | Chen C et al. | — | 2025 | → |
| From Hypothyroidism to Coronary Heart Disease: Unraveling the Lipid Profile Link: A Mendelian Randomization Study. | Li J et al. | — | 2025 | → |
| From Mind to Liver: Exploring the Causal Relationship Between Anxiety Disorders and Non-Alcoholic Fatty Liver Disease Through Mendelian Randomization and UK Biobank Validation. | Song H et al. | — | 2025 | → |
| GDF15 and its receptors as pathways mediating smoking related weight change. | Tinworth AC et al. | — | 2025 | → |
| Genetically Elevated Neutrophil Count Is Associated with Poor Outcome Following Ischemic Stroke: A Mendelian Randomization Study. | Wang M et al. | — | 2025 | → |
| Genetically informed causal links between gut microbiota and bone mass: pleiotropy and metabolic mediation. | Guan PL et al. | — | 2025 | → |
| Genetically Predict Diet-derived Antioxidants and Risk of Neurodegenerative Diseases Among Individuals of European Descent: A Mendelian Randomization Study. | Duan QQ et al. | — | 2025 | → |
| Genetically predicted ankylosing spondylitis increases the risk of heart failure: a Mendelian randomization study. | Liu C et al. | — | 2025 | → |
| Genetically predicted basal metabolic rate and infectious diseases: a Mendelian randomization study. | Li Z et al. | — | 2025 | → |
| Genetically predicted CD28 on CD4+ CD45RA+ T cells mediate the association between rheumatoid arthritis and blood leukocytes mitochondrial DNA copy number: A mediation Mendelian randomization study. | Song X et al. | — | 2025 | → |
| Genetically Predicted Gut Microbiota and Host Metabolites Mediate the Causal Link Between Dietary Factors and Acute Myeloid Leukemia. | Qin J et al. | — | 2025 | → |
| Genetically predicted mood disorders increased risk of cisplatin-induced hearing loss in childhood cancer: Evidence from a bidirectional Mendelian randomization study. | Xie S et al. | — | 2025 | → |
| Genetically Predicted Serum 25-Hydroxyvitamin D Concentrations in Related to Type 2 Diabetes Mellitus: A Mendelian Randomization Study. | Yang J | — | 2025 | → |
| Genetically predicted the causal relationship between blood metal levels and ischemic stroke risk based on Asian ethnicity. | Jing Z et al. | — | 2025 | → |
| Genetically predicted the causal relationship between gut-brain axis and chronic pain: a Mendelian randomization study. | Shi S et al. | — | 2025 | → |
| Genetically Prioritized Plasma Proteins as Candidate Therapeutic Targets for Dry Age-Related Macular Degeneration. | Hou J et al. | — | 2025 | → |
| Genetically proxied blood pressure, vascular brain injury, and Alzheimer's disease pathology. | Daghlas I et al. | — | 2025 | → |
| Genetic analysis of the correlation between GLP1 action and metabolic liver disease: Insights from Mendelian randomization analysis. | Ma Z et al. | — | 2025 | → |
| Genetic analysis the causal associations between metal elements and thyroid cancer: a bidirectional Mendelian randomization. | Yan S et al. | — | 2025 | → |
| Genetic Association and Causal Effects Between Obesity and Multiple Sclerosis: A Robust Two-Sample Mendelian Randomization Study. | Almosallam A | — | 2025 | → |
| Genetic association and potential mediators between subjective well-being and cardiovascular events: A bidirectional two-sample, two-step Mendelian randomization study. | Shen R et al. | — | 2025 | → |
| Genetic association of lipid-lowering drug target genes with cholecystitis: A summary-data-based Mendelian randomization analysis. | Zhao K et al. | — | 2025 | → |
| Genetic Association of Lipids and Lipid-Lowering Drug Target Genes With Atopic Dermatitis: A Drug Target Mendelian Randomization Study. | Luo M et al. | — | 2025 | → |
| Genetic correlation and causation of craniofacial microsomia with 33 diseases in Asian populations: insights from large-scale genome-wide cross-trait analysis. | Luo P et al. | — | 2025 | → |
| Genetic Correlation and Mendelian Randomization Analyses Support Causal Relationships Between Instant Coffee and Age-Related Macular Degeneration. | Jia Q et al. | — | 2025 | → |
| Genetic Determinants of Leukocyte Count in Nonsyndromic Cleft Lip With or Without Cleft Palate Among Asians. | Xing C et al. | — | 2025 | → |
| Genetic Downregulation of Interleukin-6 Signaling, Coagulation Function, and Risk of Thromboembolic Disease. | Daghlas I et al. | — | 2025 | → |
| Genetic evidence for causal links between type 1 diabetes and autoimmune liver diseases. | Liang C et al. | — | 2025 | → |
| Genetic Evidence for Causal Relationships Between Circulating Cathepsin Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Study. | Duan C et al. | — | 2025 | → |
| Genetic evidence linking gastroesophageal reflux disease to chronic kidney disease and kidney failure: a two-step Mendelian randomization study. | Zheng F et al. | — | 2025 | → |
| Genetic evidence of association between family factors and the risk of stroke: A 2-sample Mendelian randomization analysis. | Wang B et al. | — | 2025 | → |
| Genetic evidence of dietary patterns and diet-derived antioxidants on polyp development through gut microbiota modulation. | Zou Y et al. | — | 2025 | → |
| Genetic evidence of the causal relationship between serum micronutrients and Graves' disease: A Mendelian randomization and cross-sectional observational study. | Zhang J et al. | — | 2025 | → |
| Genetic evidence on the crucial role of immune cells in postpartum depression: Mendelian randomization analysis. | Lu H et al. | — | 2025 | → |
| Genetic evidence reveals phosphatidylcholine as a mediator in the causal relationship between omega-3 and multiple myeloma risk. | Li J et al. | — | 2025 | → |
| Genetic influence of the brain on epigenetic age acceleration: evidence of a large-scale genetic correlation study. | Li C et al. | — | 2025 | → |
| Genetic Insights Into Skin Diseases and Depression: Evidence From East Asian Mendelian Randomization Analysis. | Lin S et al. | — | 2025 | → |
| Genetic insights into the effect of Metformin on psychiatry disorders. | Zhou Q et al. | — | 2025 | → |
| Genetic insights into the mediating role of cardiac function in hypertension-induced brain cortical changes: a Mendelian randomization study with cardiac magnetic resonance imaging. | Wen J et al. | — | 2025 | → |
| Genetic insights into visceral obesity with health conditions, from disease susceptibility to therapeutic intervention. | Zhang G et al. | — | 2025 | → |
| Genetic liability to atrial fibrillation, aortic valve disease, and mitral valve disease: a two-sample Mendelian randomization study. | Zhang Y et al. | — | 2025 | → |
| Genetic Liability to Bone Mineral Density and Functional Outcome After Ischemic Stroke. | Fan D et al. | — | 2025 | → |
| Genetic liability to depression and cerebral small vessel disease: A mendelian randomization study. | Wang M et al. | — | 2025 | → |
| Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations. | Jiang X et al. | — | 2025 | → |
| Genetic prediction of blood metabolites and causal relationships with pain associated with temporomandibular disorders: a Mendelian randomization study. | Zhang X et al. | — | 2025 | → |
| Genetic prediction of the effect of gut microbiota on retinal vein occlusion via blood metabolites. | Xie X et al. | — | 2025 | → |
| Genetic prediction of the relationship between mitochondrial proteins and diabetic polyneuropathy risk: a Mendelian randomization study. | Wang Z et al. | — | 2025 | → |
| Genetic Susceptibility to Causal Relationship Between Iron Metabolism Disorder Involving Immunocytes and Risk of Pneumonia and Sepsis. | Wu Z et al. | — | 2025 | → |
| Genetic variants of glucose-dependent insulinotropic polypeptide (GIP) signalling as proxy for body weight reduction and cardiovascular risk. | Emanuelsson F et al. | — | 2025 | → |
| Genetic Variants Specific to Critical COVID-19: Insights From Genome-Wide Association Studies and Structural Analysis. | Chen H et al. | — | 2025 | → |
| Genome- and Exome-Wide Identification of Common-to-Rare Variants Associated with Middle Ear Cholesteatoma. | Qiu K et al. | — | 2025 | → |
| Genome-wide insights of shared genetic architecture between menstrual traits and bone mineral density. | Lei B et al. | — | 2025 | → |
| Getting to GRIPS with MR-Egger: Modelling directional pleiotropy independently of allele coding. | Dudbridge F et al. | — | 2025 | → |
| Glucokinase activator, circulating metabolites, and cardio-cerebrovascular diseases: a Mendelian randomization study. | Wang X et al. | — | 2025 | → |
| Glutamine and allergic rhinitis: A bidirectional two-sample Mendelian randomization study. | Fan S et al. | — | 2025 | → |
| Glutaryl-CoA dehydrogenase (GCDH) enhances renal malignancy risk via modulating glutarylcarnitine levels. | Liu X et al. | — | 2025 | → |
| Grip strength: are some adiposity phenotypes more detrimental than others? A Mendelian randomization study. | Taylor AE et al. | — | 2025 | → |
| Gut microbiome and diabetic kidney disease: Insights from Mendelian randomization and genetic correlations. | Yang K et al. | — | 2025 | → |
| Gut microbiome and peritoneal inflammation: a new perspective on peritoneal dialysis-associated peritonitis. | Xu P et al. | — | 2025 | → |
| Gut microbiota and breast cancer risk: a Mendelian randomization study stratified by ER status. | Yue J et al. | — | 2025 | → |
| Gut microbiota and diabetic neuropathy/peripheral artery disease: A two-sample Mendelian randomization study investigating risk factors for diabetic foot ulcers. | Tang G et al. | — | 2025 | → |
| Gut microbiota and insomnia: Mendelian randomization and network pharmacology to predict potential intervention with traditional Chinese medicine. | Wang X et al. | — | 2025 | → |
| Gut microbiota and protein-to-protein ratios in NAFLD: insights from Mendelian randomization and murine studies. | Lei L et al. | — | 2025 | → |
| Gut microbiota and risk of cervical cancer: a Mendelian multivariable randomization study. | Lu L et al. | — | 2025 | → |
| Gut microbiota as a causal mediator linking inflammatory cytokines and ageing phenotypes. | Liu Q et al. | — | 2025 | → |
| Gut microbiota causally affects ulcerative colitis by potential mediation of plasma metabolites: A Mendelian randomization study. | Zhao S et al. | — | 2025 | → |
| Gut Microbiota in Lactose Intolerance: A Mendelian Randomization Study on Microbial Mechanisms and Potential Links to Tumor Inflammatory Microenvironments. | Xie Y et al. | — | 2025 | → |
| Gut microbiota-mediated targeting of EHMT2 in individuals of European ancestry: A novel therapeutic approach for Alzheimer's disease. | Yan Y et al. | — | 2025 | → |
| Gut microbiota, plasma metabolites, and venous thromboembolism: a Mendelian randomization study. | Cheng PF et al. | — | 2025 | → |
| GWAS for primary angle-closure glaucoma identifies loci related to ocular biometry and morphology. | Luben RN et al. | — | 2025 | → |
| Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study. | Ge X et al. | — | 2025 | → |
| Higher levels of plasma phosphatidylcholine (17:0_18:1) raise the risk of developing Parkinson's disease. | Su D et al. | — | 2025 | → |
| HLA-DOB: A Key "Coordinator" Between Cutaneous Melanoma and Psoriasis. | Li Y et al. | — | 2025 | → |
| Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry. | Schuermans A et al. | — | 2025 | → |
| Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases. | Bhak Y et al. | — | 2025 | → |
| Identification and Validation of Novel Lipids Linked to Bone Mineral Density Change and Fracture Risk. | Ma C et al. | — | 2025 | → |
| Identification Exploring the Mechanism and Clinical Validation of Mitochondrial Dynamics-Related Genes in Membranous Nephropathy Based on Mendelian Randomization Study and Bioinformatics Analysis. | Shao Q et al. | — | 2025 | → |
| Identification of biomarkers of Shenhailong formula in benign prostatic hyperplasia treatment: An observation study using network pharmacology and Mendelian randomization analysis. | Pan J et al. | — | 2025 | → |
| Identification of cancer-associated fibroblast signature genes for potential biomarkers in cholangiocarcinoma: a Mendelian randomization study. | Hu S et al. | — | 2025 | → |
| Identification of Cathepsin H and Metabolic Traits as Potential Biomarkers for Lung Cancer by Mendelian Randomization and Single-Cell Transcriptomics. | Song C et al. | — | 2025 | → |
| Identification of Co-Diagnostic Genes and Potential Therapeutic Targets for Asthma and Sepsis Through Mendelian Randomization and Immune Infiltration Analysis. | Chen C et al. | — | 2025 | → |
| Identification of comorbid genes between type 2 diabetes and migraine through peripheral blood single-cell and Mendelian randomization analysis. | Yuan B et al. | — | 2025 | → |
| Identification of <i>TMEM106B</i> as a Shared Potential Drug Target for Depression and Stroke Through Comprehensive Genetic Analyses. | Zhang W et al. | — | 2025 | → |
| Identification of Novel Biomarkers and Potential Therapeutic Targets for Systemic Sclerosis: An Integrated Analysis of Plasma Proteome-Wide Mendelian Randomization and Transcriptome. | Li H et al. | — | 2025 | → |
| Identification of novel high-risk genes in gastric cancer through single-cell RNA sequencing, eQTL Mendelian randomization, and in vitro validation. | Qi L et al. | — | 2025 | → |
| Identification of novel therapeutic targets for cognitive performance and associations with brain health. | Zhang LY et al. | — | 2025 | → |
| Identification of plasma protein biomarkers for ankylosing spondylitis by integrating proteome with genome. | Wang M et al. | — | 2025 | → |
| Identification of potential key targets and mechanisms underlying cleft palate induced by tobacco smoke exposure through multi-omics integrated Mendelian randomization analysis. | Lin Y et al. | — | 2025 | → |
| Identification of potential therapeutic targets for problematic alcohol use using multi-omics data. | Lee DJ et al. | — | 2025 | → |
| Identification of prognostic genes associated with mitochondria and macrophage polarization in prostate adenocarcinoma based on transcriptome and Mendelian randomization analysis. | Heng L et al. | — | 2025 | → |
| Identification of protein targets for dyslipidaemia and cardiovascular diseases among people with South Asian ancestry: a mendelian randomisation study. | Wu S et al. | — | 2025 | → |
| Identification of SARS2, PKN1, and IL11RA as causally-associated genes for patients with gastric cancer via immune cell activity: A multi-omics Mendelian randomization study integrating GWAS, eQTL, and pQTL data. | Tang C et al. | — | 2025 | → |
| Identification of senescence-related biomarkers for osteoporosis based on microarray analysis, Mendelian randomization, and experimental validation. | Zhu Y et al. | — | 2025 | → |
| Identification of therapeutic targets for psoriatic arthritis through proteomics. | Zhang F et al. | — | 2025 | → |
| Identifying causal genes for prostatitis through drug-targeted Mendelian randomization. | Yan K et al. | — | 2025 | → |
| Identifying Common Diagnostic Biomarkers and Therapeutic Targets between COPD and Sepsis: A Bioinformatics and Machine Learning Approach. | Li X et al. | — | 2025 | → |
| Identifying CTSF and GSTM3 as chemoresistance therapeutic targets in breast cancer through multi-omics MR analysis. | Liu R et al. | — | 2025 | → |
| Identifying diagnostic biomarkers for glaucoma based on transcriptome combined with Mendelian randomization. | Lin X et al. | — | 2025 | → |
| Identifying modifiable factors and their causal effects on osteoporosis risk. | Jiang S et al. | — | 2025 | → |
| Identifying novel risk targets in inflammatory skin diseases by comprehensive proteome-wide Mendelian randomization study. | Li Y et al. | — | 2025 | → |
| Identifying Targets and Drugs for Rheumatoid Arthritis Stratified Therapy Using Mendelian Randomization and a Pretraining Model. | Yan Y et al. | — | 2025 | → |
| IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk. | Zhang L et al. | — | 2025 | → |
| IL7R<sup>+</sup> T Cell-Macrophage Crosstalk Links Asthma to Alzheimer's Pathogenesis: Integrating Mendelian Randomization and CellChat Analysis. | Yang J et al. | — | 2025 | → |
| Illuminating the intricate role of genetic factors in chronic low back pain: from the molecular basis of onset to the determination of susceptibility and the search for novel therapeutic avenues. | Chen DQ et al. | — | 2025 | → |
| Immune, blood-brain barrier, and metabolic biomarkers mediate gut-brain axis crosstalk in alzheimer's disease. | Li J et al. | — | 2025 | → |
| Immune cells and the risk of acne vulgaris: A Mendelian randomization study. | Yang X et al. | — | 2025 | → |
| Immune cells, inflammatory proteins, and sepsis: A mediation Mendelian randomization study. | Zhang Y et al. | — | 2025 | → |
| Immune cells mediate the association between the plasma lipidome and pancreatic cancer: a Mendelian randomization analysis. | Ma C et al. | — | 2025 | → |
| Immune Cells Mediate the Causal Pathway Linking Multisite Chronic Pain to Asthma: A Mediation Mendelian Randomization Study. | Chen JH et al. | — | 2025 | → |
| Immune-mediated bone loss: A Mendelian randomization and NHANES-based study of viral infections and osteoporosis. | Xiong L et al. | — | 2025 | → |
| Immune-metabolic perspective on the association of seven psychiatric disorders and five common auditory diseases: a bidirectional two-sample Mendelian randomization study and mediation analysis. | Yang J et al. | — | 2025 | → |
| Immunological determinants of pterygium pathogenesis: Mendelian randomization analysis of CD39 + CD8 + T cell proportions within the T cell compartment. | Yang J et al. | — | 2025 | → |
| Immunosuppressant use may be a potential mediator in the progression of systemic lupus erythematosus to osteomyelitis: A bidirectional Mendelian randomization study. | Hu M et al. | — | 2025 | → |
| Impact of age at first sexual intercourse on the development and prognosis of breast cancer: A two-sample Mendelian randomization study with NHANES validation. | Yang X et al. | — | 2025 | → |
| Impact of Immune Cells on IgA Vasculitis via Metabolites and Inflammatory Cytokines. | Xie M et al. | — | 2025 | → |
| Impact of mild cortisol excess on osteoporosis and the mediating role of sarcopenia-related traits: A Mendelian randomization study. | Zhu J et al. | — | 2025 | → |
| Independent Effects of Hypothyroidism and Obesity on Endometrial Cancer Risk Revealed by Mendelian Randomisation. | Glubb DM et al. | — | 2025 | → |
| Independent effects of mental health disorders on breast cancer and their mediating factors: evidence from NHANES and two-step Mendelian randomization. | Ma K et al. | — | 2025 | → |
| Inferring multi-organ genetic connections using imaging and clinical data through Mendelian randomization. | Shu J et al. | — | 2025 | → |
| Inflammation biomarkers mediate causal inference of the effect of skin microbiota on the risk of allergic diseases. | Zhang Y et al. | — | 2025 | → |
| Inflammatory Bowel Disease Mediates the Causal Relationship Between Gut Microbiota and Colorectal Cancer: Identification of Therapeutic Targets and Predictive Modeling. | Wang JB et al. | — | 2025 | → |
| Inflammatory index-based nomogram for risk stratification of erectile dysfunction: a cross-sectional study with dual-cohort validation and mendelian randomization analysis. | Shi Z et al. | — | 2025 | → |
| Inflammatory Proteins Mediate the Effect of Gut Microbiota on Graves' Ophthalmopathy: A Mendelian Randomization Study. | Li Y et al. | — | 2025 | → |
| Insights into the impact of neuropsychiatric disorders on prostate diseases: A 2-sample Mendelian randomization study. | Xie H et al. | — | 2025 | → |
| Insomnia Proven to be Associated With Prostate Cancer: A Genetic Correlation Study Incorporating Lifestyle Factors. | Chen X et al. | — | 2025 | → |
| Integrated genetic analysis of Alzheimer's disease and stroke subtypes: insights from LDSC, PLACO, and MR studies. | Long Y et al. | — | 2025 | → |
| Integrated multi-omics identifies GZMA targeting NK cells as a novel therapeutic strategy for hidradenitis suppurativa. | Yao J et al. | — | 2025 | → |
| Integrating Expression Quantitative Trait Loci and Genome-Wide Association Study Identifies Druggable Genes for Tinnitus. | Guo T et al. | — | 2025 | → |
| Integrating genetics and transcriptome analyses identify potential biomarkers and immune interactions in metabolic syndrome-related sarcopenia. | Fu W et al. | — | 2025 | → |
| Integrating Human Proteomes with Genome-Wide Association Data Reveals Prioritized Therapeutic Candidates for Lung Squamous Cell Carcinoma. | Zhang Y et al. | — | 2025 | → |
| Integrating multi-omics to reveal the causal effect of gut microbiota on post-traumatic stress disorder and potential drug target analysis. | Huang H et al. | — | 2025 | → |
| Integrating plasma proteomics and genome-wide association data to identify therapeutic targets for retinal neurodegenerative diseases in Europeans. | Guo YJ et al. | — | 2025 | → |
| Integrating Single-Cell Transcriptome-Wide Mendelian Randomization and Differentially Expressed Gene Analyses to Prioritize Dynamic Immune-Related Drug Targets for Cancers. | Zheng J et al. | — | 2025 | → |
| Integration of summary data from GWAS and eQTLs studies predicts causality of S1PR1 and breast cancer. | Shi H et al. | — | 2025 | → |
| Integrative evidence for causal links between gut microbiota and Schizophrenia: A Mendelian randomization and 16S rRNA study. | Zeng J et al. | — | 2025 | → |
| Integrative evidence linking excessive daytime sleepiness, narcolepsy, and hypertension: insights from NHANES, Mendelian randomization, and proteomics. | Feng S et al. | — | 2025 | → |
| Integrative genetic and multi-omics analysis reveals the interleukin-6 receptor's role in recurrent spontaneous abortion. | Ma W et al. | — | 2025 | → |
| Integrative genome-wide analysis unveils the genetic landscape of gallstone disease and highlights novel loci with therapeutic potential. | Chen H et al. | — | 2025 | → |
| Integrative Mendelian randomization analysis to identify causal plasma proteins and therapeutic targets for delirium. | Hao R et al. | — | 2025 | → |
| Integrative Mendelian randomization for detecting exposure-by-group interactions using group-specific and combined summary statistics. | Xu K et al. | — | 2025 | → |
| Integrative multi-omics analysis identifies mitochondria- and ferroptosis-related prognostic genes in cervical cancer. | Jia L et al. | — | 2025 | → |
| Investigating antidiabetic drug targets as potential therapeutic modulators for schizophrenia. | Huang YS et al. | — | 2025 | → |
| Investigating bidirectional causal relationships between gut microbiota and insomnia. | Shi S et al. | — | 2025 | → |
| Investigating potential biomarkers associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis using Mendelian randomization and transcriptomic analysis. | Wang Y et al. | — | 2025 | → |
| Investigating shared genetic architecture between major depressive disorder and central obesity. | Zhan Y et al. | — | 2025 | → |
| Investigating the association between anthropometry and colorectal cancer survival: a two-sample Mendelian randomization analysis. | Kanellopoulou A et al. | — | 2025 | → |
| Investigating the Causal Relationship and Shared Genetic Basis Between Major Depression Disorder and Eight Types of Gastrointestinal Diseases. | Sun F et al. | — | 2025 | → |
| Investigating the causal relationship between multimodal brain imaging-derived phenotypes and insomnia: A Mendelian randomization study. | Gu H et al. | — | 2025 | → |
| Investigating the causal role of cellular senescence-related genes in preeclampsia: a multi-omics Mendelian randomization study with differential expression analysis. | Zhu H et al. | — | 2025 | → |
| Investigating the causal role of the gut microbiome in Kawasaki disease: mediating effects of immune cells. | Fan Y et al. | — | 2025 | → |
| Investigating the correlation between tea intake and glioblastoma: A Mendelian randomization study. | Zhang C et al. | — | 2025 | → |
| Investigating the genetic causality between periodontitis and intracranial aneurysms: A 2-sample Mendelian randomization study. | Chen Y et al. | — | 2025 | → |
| Investigating the mediating effect of plasma metabolites on the gut microbiome in influencing Behçet disease: A multi-omics validated Mendelian randomization study. | Guo T et al. | — | 2025 | → |
| Investigating the relationship between breast cancer risk factors and an AI-generated mammographic texture feature in the Nurses' Health Study II. | Wu X et al. | — | 2025 | → |
| Investigating the relationship of plasma microRNAs and colorectal cancer risk using genetic evidence. | Bouras E et al. | — | 2025 | → |
| Investigating the role of homocysteine and B vitamins in gestational diabetes mellitus: Mendelian randomization study. | Zhan X et al. | — | 2025 | → |
| Investigating the shared genetic architecture between adiposity measures and obesity-related cancers. | Wang S et al. | — | 2025 | → |
| Investigating the visceral adiposity-major depressive disorder link: a cross-sectional NHANES 2011-2014 analysis and Mendelian randomization study. | Hu M et al. | — | 2025 | → |
| Investigation of Genetic Causality Between Epstein-Barr Virus Infection and Risk of Autoimmune Diseases. | Hu X et al. | — | 2025 | → |
| Iron Homeostasis as a Mediator Linking Central Obesity with MASLD and Primary Liver Cancer: A Two-Step Mendelian Randomization Study. | Zeng Y et al. | — | 2025 | → |
| Is there a genetic correlation between tinnitus and temporomandibular joint disorder?: A two-sample Mendelian randomization study. | Ma X et al. | — | 2025 | → |
| Lack of evidence for obesity paradox in patients with cardiovascular disease: A UK BioBank cohort study. | Yu W et al. | — | 2025 | → |
| Lack of genetic correlation and causal association between specific gut microbiota and osteoporosis. | Chen D et al. | — | 2025 | → |
| Leveraging Genomic Data to Examine the Causal Impact of Alcohol, Tobacco, Cannabis, and Opioid Use on Biological and Cognitive Ageing. | Balbona JV et al. | — | 2025 | → |
| Lipid-lowering drug targets influence inflammatory bowel disease through gut microbiota and inflammatory cytokines. | Huang X et al. | — | 2025 | → |
| Lipid metabolism and osteonecrosis: unraveling causal mechanisms via multi-omics and mendelian randomization. | Chen Y et al. | — | 2025 | → |
| Lipids, Lipid-Lowering Drug Target Genes, and COPD Risk: A Mendelian Randomization Study. | Jia G et al. | — | 2025 | → |
| Liposomes, immune cells, and lung cancer subtypes: A bidirectional Mendelian randomization study. | Tian K et al. | — | 2025 | → |
| Local Genetic Correlations and Pleiotropy Reveal Shared Genetic Architecture Between COVID-19 Phenotypes and Prostate Cancer in European Populations. | Xiang R et al. | — | 2025 | → |
| Longitudinal change and causal relationship between gut microbiota and gestational diabetes mellitus. | Wu X et al. | — | 2025 | → |
| Low bone mineral density as a causal risk factor for cervical and thoracolumbar intervertebral disc degeneration: A Mendelian randomization analysis. | Huang L et al. | — | 2025 | → |
| <i>VEGFB</i> is a potential therapeutic target for Alzheimer's disease: Insights from integrative multi-omics analysis. | Ye H et al. | — | 2025 | → |
| Lung cancer and COVID-19 susceptibility and severity: a Mendelian randomization analysis. | Bai M et al. | — | 2025 | → |
| Magnetic resonance imaging quantifies causal body compartment effects on metabolic traits via immune phenotypes-a Mendelian randomisation study. | Zhang D et al. | — | 2025 | → |
| Major Depression as a Catalyst for Nonalcoholic Fatty Liver Disease: Insights From a Comprehensive Mendelian Randomization Study. | Su Y et al. | — | 2025 | → |
| Male infertility and the risk of developing prostate cancer: a bidirectional two-sample Mendelian randomization study. | Shao J et al. | — | 2025 | → |
| Mediating role of basophils in the triacylglycerol-asthma link: a Mendelian randomization study. | Hu X et al. | — | 2025 | → |
| Mediating role of thyroid dysfunction in the relationship between insomnia and osteoporosis: A Mendelian randomization analysis. | Wu L et al. | — | 2025 | → |
| Mediation Mendelian randomization study of plasma proteomics reveals the causal relationship and potential mechanisms between iron and colorectal adenocarcinoma. | Chen X et al. | — | 2025 | → |
| Mendelian randomisation analysis to discover plasma metabolites mediating the effect of obesity on cancer risk. | Yates T et al. | — | 2025 | → |
| Mendelian randomisation and single-cell transcriptomic analyses reveal serotonin promotes multiple sclerosis progression by suppressing adenosine deaminase activity. | Huang L et al. | — | 2025 | → |
| Mendelian randomization analyses explore the causal relationship between fibroblast growth factor receptors and hypertrophic scar. | Ma HF et al. | — | 2025 | → |
| Mendelian randomization analyses support causal relationship between brain imaging-derived phenotypes and risk of low back pain. | Xie XY et al. | — | 2025 | → |
| Mendelian Randomization Analyses Support Causal Relationships Between Psychiatric Disorders and Risk of Urinary Tract Infections. | Ke M et al. | — | 2025 | → |
| Mendelian randomization analysis: causal link between hyperthyroidism/thyrotoxicosis and ovarian cancer. | Wang H et al. | — | 2025 | → |
| Mendelian randomization analysis of C-reactive protein on septic arthritis risk. | Lei H et al. | — | 2025 | → |
| Mendelian randomization analysis of lipidomic profiles and thyroid cancer risk in European populations. | Li S et al. | — | 2025 | → |
| Mendelian randomization analysis of lipids traits and lipid-lowering drug-targets in relation to cognitive status. | Fu J et al. | — | 2025 | → |
| Mendelian randomization analysis of the causal relationship between COPD and type 1 and type 2 diabetes mellitus. | Wu Y et al. | — | 2025 | → |
| Mendelian Randomization Analysis of the Relationship Between Immune-Related Diseases and Alzheimer's Disease. | Huang DH et al. | — | 2025 | → |
| Mendelian randomization analysis reveals causal effects of metformin on bipolar disorder risk. | Li Z et al. | — | 2025 | → |
| Mendelian Randomization Analysis Reveals No Causal Genetic Link Between Dentofacial Anomalies and Dental Caries. | Wang X et al. | — | 2025 | → |
| Mendelian randomization analysis unveils causal relationships between skin microbiota and osteomyelitis. | Wang Y et al. | — | 2025 | → |
| Mendelian randomization analysis with the GEO database: Exploring the molecular mechanism underlying insulin therapy for perioperative neurocognitive disorders. | Jian C et al. | — | 2025 | → |
| Mendelian randomization and AlphaFold3 analysis suggest putative causal plasma proteins in graves' disease. | Deng B et al. | — | 2025 | → |
| Mendelian randomization and colocalization analyses reveal an association between diet consumption and altered telomere length in leukocytes. | Wang B et al. | — | 2025 | → |
| Mendelian Randomization and Transcriptome Analyses Reveal Important Roles for CEBPB and CX3CR1 in Osteoarthritis. | Gao H et al. | — | 2025 | → |
| Mendelian randomization and transcriptomic data analysis reveals the causal association between gout and breast cancer. | Zhang H et al. | — | 2025 | → |
| Mendelian randomization combined with single-cell sequencing analysis revealed prognostic genes related to myeloid cell differentiation in prostate cancer and experimental verification. | Chen J et al. | — | 2025 | → |
| Mendelian Randomization Evidence for Relationship and Mediation of Educational Attainment on Chronic Obstructive Pulmonary Disease. | Yang X et al. | — | 2025 | → |
| Mendelian Randomization Identifies CD25+ CD4+ Tregs and Plasma Proteins in Androgenetic Alopecia Pathogenesis. | Du Y et al. | — | 2025 | → |
| Mendelian randomization in SLEEP: avoiding pitfalls with MR-SLEEP guidelines. | Evans DS et al. | — | 2025 | → |
| Mendelian randomization investigation: Exploring the relationship between phosphatidylinositol levels and hypertrophic cardiomyopathy risk through interleukin-20 receptor subunit alpha expression. | Huang L et al. | — | 2025 | → |
| Mendelian randomization revealed a one-way causal association between increased Isovalerylcarnitine (C5) levels and the risk of idiopathic pulmonary fibrosis. | He J et al. | — | 2025 | → |
| Mendelian Randomization Reveals Unidirectional Links Between Amyloid-β and Tau in Alzheimer's Disease. | Kim JP et al. | — | 2025 | → |
| Mendelian Randomization Studies of Myopia: Choosing the Right Summary Statistics. | Nguyen TN et al. | — | 2025 | → |
| Mendelian randomization study explores the peripheral immunological characteristics of colorectal cancer. | Yuan C et al. | — | 2025 | → |
| Mendelian randomization study of micronutrients and development of CKD in a Korean population. | Lee J et al. | — | 2025 | → |
| Mendelian randomization study of self-reported long sleep duration, short sleep duration, and insomnia and cognitive function. | Guo Y | — | 2025 | → |
| Mendelian Randomization Study of Sex Hormone Binding Globulin and Its Influence on Adverse Pregnancy Outcomes. | Wu H et al. | — | 2025 | → |
| Mendelian randomization study reveals the causal effect of sex hormone binding globulin on osteoporosis. | Zuo GS et al. | — | 2025 | → |
| Mendelian randomization study: The association between pain, analgesics, and frailty. | Wu Z | — | 2025 | → |
| Mendelian randomization underscores the importance of clinical nursing in mitigating anxiety and panic attack risks among low-educated populations. | Li H et al. | — | 2025 | → |
| Mendelian randomization unveils genetic causal relationships between viral infections and systemic sclerosis. | Cheng T et al. | — | 2025 | → |
| Metabolism-Mediated FGF5 Association with Stroke: Based on Mendelian Randomization and Bioinformatics Analysis. | Xu C et al. | — | 2025 | → |
| Metformin reduces the risk of frailty: evidence from a Mendelian randomization study. | Chen T et al. | — | 2025 | → |
| Mitochondrial DNA Copy Number and Risk of Gestational Metabolic Disorders: A Two-Sample Mendelian Randomization Study. | Zhan F et al. | — | 2025 | → |
| Mitochondrial DNA copy number as a genetic determinant of renal function: insights from bidirectional Mendelian randomization. | Wang S et al. | — | 2025 | → |
| Mitochondrial proteins contribute to the pathogenesis of myasthenia gravis. | Cao F et al. | — | 2025 | → |
| Mobile phone usage duration and male fertility: A two-sample Mendelian randomization analysis. | Xiang Y et al. | — | 2025 | → |
| Molecular insights into gender-specific differences in rheumatoid arthritis: A study using high-throughput sequencing and Mendelian randomization. | Wang D et al. | — | 2025 | → |
| Mood instability and 22 gastrointestinal disorders: investigating the causal relationships and the mediating factors by Mendelian randomization analysis. | Yan F et al. | — | 2025 | → |
| MR analysis reveals no causal association between mitochondrial DNA copy number and osteoporosis. | Xiao M et al. | — | 2025 | → |
| MR-EILLS: an invariance-based Mendelian randomization method integrating multiple heterogeneous GWAS summary datasets. | Hou L et al. | — | 2025 | → |
| Multidimensional Evidence Chain of Nutritional Impact on Digestive System Tumors: Integration of Mendelian Randomization Causal Inference, NHANES Epidemiological Data, and Transcriptomic Analysis. | Chen Y et al. | — | 2025 | → |
| Multifaceted dietary exposures and atrial fibrillation: Bidirectional causal evidence from two-sample Mendelian randomization study. | Li H et al. | — | 2025 | → |
| Multi-Omics Analyses Reveal Relationships Between Gut Microbiota and Frailty. | Hou X et al. | — | 2025 | → |
| Multi-Omics Analysis Reveals Causal Relationships and Potential Mediators Between Dietary Preferences and Risk of NAFLD. | Fu Q et al. | — | 2025 | → |
| Multi-omics analysis reveals glutathione metabolism-related immune suppression and constructs a prognostic model in lung adenocarcinoma. | Chi Y et al. | — | 2025 | → |
| Multi-omics identification of circulating protein biomarkers for intervertebral disc degeneration using Mendelian randomization and scRNA-seq. | Bai F et al. | — | 2025 | → |
| Multi-omics integration analysis based on plasma circulating proteins reveals potential therapeutic targets for ulcerative colitis. | Zhou J et al. | — | 2025 | → |
| Multi-omics integration reveals Chr1 associated QTL mediating backfat thickness in pigs. | Yu N et al. | — | 2025 | → |
| Multi-Omics Mendelian Randomization Identifies a DNA Methylation-ZDHHC20-Immune Axis Associated With Schizophrenia Risk. | Guo Q et al. | — | 2025 | → |
| Multi-omics Mendelian randomization integrating RNA-seq, eQTL and pQTL data revealed CPXM1 as a potential drug target for osteoporosis. | Lian J et al. | — | 2025 | → |
| Multi-omic underpinnings of heterogeneous aging across multiple organ systems. | Xiong J et al. | — | 2025 | → |
| Multivariate genome-wide analyses of insulin resistance unravel novel loci and therapeutic targets for cardiometabolic health. | Ye C et al. | — | 2025 | → |
| Natural active ingredients targeted inflammatory cytokines and major blinding eye diseases: a two-sample Mendelian randomization and molecular docking analysis. | Shao Y et al. | — | 2025 | → |
| Negative emotions mediate the causal association between GERD and MG: A mediation Mendelian randomization study. | Li P et al. | — | 2025 | → |
| Neuroprotective mechanisms of valproic acid and alpha-lipoic acid in ALS: a network pharmacology-based investigation. | Zhang D et al. | — | 2025 | → |
| Neuroticism, omega-3 fatty acids, and risk of incident dementia. | Gao Y et al. | — | 2025 | → |
| New drug targets for acute myeloid leukemia identified through a comprehensive analysis of the plasma protein. | Hong Y et al. | — | 2025 | → |
| New insights into genetic comorbidity mechanisms: type 2 diabetes and primary open-angle glaucoma. | Wang Y et al. | — | 2025 | → |
| No Evidence for a Causal Association Between Depression and Herpes Zoster or Post-Herpetic Neuralgia: A Mendelian Randomization Study. | Zhang X et al. | — | 2025 | → |
| No evidence of a causal relationship between negative emotions and glaucoma: evidence triangulation from genetic correlation, Mendelian randomisation and colocalisation. | Qi J et al. | — | 2025 | → |
| No More Free Lunch: Challenges to Mendelian Randomization Due to Sample Selection and Complex Methods. | Lu T et al. | — | 2025 | → |
| Noninvasive markers for warning premature ovarian insufficiency: a Mendelian randomisation study. | Tan H et al. | — | 2025 | → |
| Novel Genetic Loci for Nontuberculous Mycobacterial Pulmonary Disease and Potential Protective Effect of Body Mass Index. | Park K et al. | — | 2025 | → |
| Novel High-Resolution Lipidomes Could Serve as New Biomarkers for Diabetic Retinopathy: A Bidirectional and Mediated Mendelian Randomization Study. | Sun Y et al. | — | 2025 | → |
| Novel Insights Into the Causal Association Between Dietary Factors and Risk of Urinary Calculus: A Multivariate and Two-Step Mendelian Randomization Analysis. | Tang X et al. | — | 2025 | → |
| Novel insights into the relationship between glaucoma and brain diseases from the genetic to diseases levels: A cross-sectional study. | Chen X et al. | — | 2025 | → |
| Novel therapeutic targets for metabolism-related diseases: proteomic Mendelian randomization and colocalization analyses. | Zhang YY et al. | — | 2025 | → |
| Obesity, plasma metabolites, and hypertension: A mediation Mendelian randomization study based on STROBE-MR guidelines. | Fu H | — | 2025 | → |
| Observational and Genetic Evidence Reveals the Effect of Serum Lipid Levels on COPD Risk. | Jia G et al. | — | 2025 | → |
| Omega-6/Omega-3 Ratio as a Protective Factor in Lung Cancer: A Mendelian Randomization Study on Polyunsaturated Fatty Acids and Lung Adenocarcinoma Risk. | Wang C et al. | — | 2025 | → |
| Oncostatin M mediates the causal relationship between obesity and chronic kidney disease: evidence from Mendelian randomization and experimental validation. | Zhang X et al. | — | 2025 | → |
| One-carbon metabolism and risk of PCOS: insights from Mendelian randomization. | Zhao Y et al. | — | 2025 | → |
| Optimizing treatment of cardiovascular risk factors in cerebral small vessel disease using genetics. | Koohi F et al. | — | 2025 | → |
| Oral and gut microbiota in gingivitis subtypes: a causal inference study using Mendelian randomization. | Lin J et al. | — | 2025 | → |
| Outlier Detection in Mendelian Randomization. | Mandl MM et al. | — | 2025 | → |
| Pan-cancer analysis of the impact of fatty acids: a two-sample and multivariable Mendelian randomization study. | Kuang X et al. | — | 2025 | → |
| Pear-shaped body types linked to lower risk of gout: genetic evidence from Mendelian randomization. | Qiu Y et al. | — | 2025 | → |
| Personal history of irradiation and risk of osteomyelitis: A Mendelian randomization study. | Yun X et al. | — | 2025 | → |
| Perturbation of Circulating Inflammatory Proteins Mediates the Relationship Between Cholecystectomy and Nonalcoholic Fatty Liver Disease: A Multivariate and Mediation Mendelian Randomization Study. | Chen C et al. | — | 2025 | → |
| Perturbations in lipid metabolism mediate the relationship between cholecystectomy and dementia: A mediation Mendelian randomization study. | Gu H et al. | — | 2025 | → |
| Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study. | Chalitsios CV et al. | — | 2025 | → |
| Pigmentation and Retinal Pigment Epithelium Thickness: A Study of the Phenotypic and Genotypic Relationships Between Ocular and Extraocular Pigmented Tissues. | Julian TH et al. | — | 2025 | → |
| Plasma complement proteins as biomarkers and therapeutic targets in chronic kidney disease: a Mendelian randomization analysis. | Xu YP et al. | — | 2025 | → |
| Plasma metabolic landscape unveils key regulators of leukemia subtype progression. | Liang C et al. | — | 2025 | → |
| Plasma proteins and onset of atherosclerosis: integrating human plasma proteogenomics, transcriptomics and in vivo evidence. | Chen K et al. | — | 2025 | → |
| Plasma Proteome Profiling Identifies Biomarkers and Potential Drug Targets for Non-Small Cell Lung Cancer. | Zhao M et al. | — | 2025 | → |
| Polyunsaturated Fatty Acids and Skin Cancer: Two-Sample Mendelian Randomization Study. | Kim G et al. | — | 2025 | → |
| Potential Causal Effects of Cystatin C on Age-Related Macular Degeneration: A Two-Sample Mendelian Randomization Study. | Lee Y et al. | — | 2025 | → |
| Potential Causal Relationship Between Chronic Obstructive Pulmonary Disease and Diabetes: A Bidirectional Two-Sample Mendelian Randomization Study. | Wang X et al. | — | 2025 | → |
| Potential Causal Relationships Between Circulating Micronutrient Levels and Multiple Neuroimmune Diseases: A Genetic Association Analysis. | Chen L et al. | — | 2025 | → |
| Potential Risk of Cutaneous Melanoma Attributable to Medication Use: A Mendelian Randomization Approach. | Wan H et al. | — | 2025 | → |
| pQTL Mendelian randomization analysis combined with single-cell sequencing to identify biomarkers and drug targets for bladder cancer. | Gao W et al. | — | 2025 | → |
| Precision Target Discovery for Migraine: An Integrated GWAS-eQTL-PheWAS Pipeline. | Liu X et al. | — | 2025 | → |
| Prenatal and childhood exposure to mixtures of environmental chemicals and adolescence attentional problems: a triangulation study. | Fabbri L et al. | — | 2025 | → |
| Primary Biliary Cholangitis and Seropositive Rheumatoid Arthritis: A Two-Sample Mendelian Randomization Study. | Deng Z et al. | — | 2025 | → |
| Prospective evidence for the gut-bone axis in osteoporotic fractures: Insights from genetic prediction and metabolite mediators. | Zhu B et al. | — | 2025 | → |
| Prospects of Mendelian randomization in hepatology: a comprehensive literature review with practice guidance. | Chen L et al. | — | 2025 | → |
| Protective and pathogenic dietary factors in bronchitis: Insights from Mendelian randomization. | Wang J et al. | — | 2025 | → |
| Protein markers of ovarian cancer and its subtypes: insights from proteome-wide Mendelian randomisation analysis. | Mulugeta A et al. | — | 2025 | → |
| Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention. | Yarmolinsky J et al. | — | 2025 | → |
| Proteome-Wide Mendelian Randomisation Study of Adverse Perinatal Outcomes. | Daubney ER et al. | — | 2025 | → |
| Proteome-wide Mendelian randomization identifies drug targets for atrial fibrillation/flutter. | Jia Q et al. | — | 2025 | → |
| Proteome-wide Mendelian randomization reveals causal associations between plasma proteins and autoimmune thyroid disease. | Li Y et al. | — | 2025 | → |
| Proteome-wide mendelian randomization reveals circulating proteins causally associated with childhood body mass index. | Avocegamou R et al. | — | 2025 | → |
| Proteomic insights into chronic pancreatitis: Proteome-wide mendelian randomization to identify potential therapeutic targets. | Li Q et al. | — | 2025 | → |
| Proteomic ratio reveals subtype-specific genetic mechanisms and therapeutic targets in osteoarthritis. | Wang Y et al. | — | 2025 | → |
| Proton pump inhibitors and the risk of urolithiasis: A Mendelian randomization study. | Guo J et al. | — | 2025 | → |
| PTPRD pleiotropy, genetically driven childbirth timing, and corpus callosum microstructure as potential mechanisms underlying ADHD-RLS comorbidity. | Li FJ et al. | — | 2025 | → |
| Rapid eye movement sleep behavior disorder (RBD) and neurodegenerative diseases: A bidirectional 2-sample Mendelian randomization study. | Hu W et al. | — | 2025 | → |
| Real-world data and Mendelian randomization analysis in assessing adverse reactions of rilonacept. | Liu L et al. | — | 2025 | → |
| Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study. | Morales Berstein F et al. | — | 2025 | → |
| Reassessing the relationship between major depressive disorder and blood lipids: a comprehensive Mendelian randomisation study. | Sun G et al. | — | 2025 | → |
| [Reduced intestinal abundance of <i>Gordonibacter</i> increases risk of kidney stones: a Mendelian randomization study and evidence from rat models]. | Pan X et al. | — | 2025 | → |
| Regular use of pharmaceutical opioids and subsequent risk of cancer: a prospective cohort study and Mendelian randomization analysis. | Sheikh M et al. | — | 2025 | → |
| Relationship between metabolic syndrome and overactive bladder: insights from the NHANES and Mendelian randomization study. | Liu Z et al. | — | 2025 | → |
| Revealing the causal association among clonal hematopoiesis (CH), stroke and circulating inflammatory factors: A Mendelian randomization study. | Yu H et al. | — | 2025 | → |
| Revealing the causal relationship between cathepsin and inflammatory disease of wrist through Mendelian randomization. | Qu Y et al. | — | 2025 | → |
| Revealing the Causal Relationship of the Gut-Liver Axis in MASH: A Study Based on Mendelian Randomization and Multi-Omics. | Yin D et al. | — | 2025 | → |
| Revealing the genetic architectures underlying organ-specific aging based on proteomic data. | Zhu RJ et al. | — | 2025 | → |
| Rheumatoid arthritis and cardiovascular disease associations in the UK Biobank. | Salatzki J et al. | — | 2025 | → |
| Rheumatoid arthritis increases risk of atherosclerosis: A Mendelian randomization study. | Liu QP et al. | — | 2025 | → |
| Risk-based screening and prognostic analysis for second primary malignancies in kidney cancer patients: a retrospective cohort study based on large-scale population and Mendelian randomization analysis. | Zou M et al. | — | 2025 | → |
| Risk factors for sacrococcygeal pilonidal sinus: a systematic review and meta-analysis supplemented by genetic causal assessment. | Xu X et al. | — | 2025 | → |
| Role of Dendritic Cells in Mediating the Effect of Growth Differentiation Factor 15 on Nonalcoholic Fatty Liver Disease: Insights From Causal Inference and Single-Cell Profiling. | Yao T et al. | — | 2025 | → |
| Role of Lung Function, Chronic Obstructive Pulmonary Disease on Hearing Impairment: Evidence for Causal Effects and Clinical Implications. | Yuan L et al. | — | 2025 | → |
| Roles of Gut Microbiota and Associated Metabolites in <i>Clostridioides difficile</i> Infection. | Gao Y et al. | — | 2025 | → |
| Self-Report Alzheimer's Disease Statuses in UK Biobank Distort Downstream Analyses. | Hu S et al. | — | 2025 | → |
| Serum urate and pancreatitis: A bidirectional Mendelian randomization study. | Li Y et al. | — | 2025 | → |
| Serum Vitamin D Levels Over Time and the Incidence of Atrial Fibrillation in the HUNT Study. | Jiang L et al. | — | 2025 | → |
| SGLT2 inhibitor, bone metabolism biomarkers, and osteoporosis risk: A Mendelian randomization study. | Wang X et al. | — | 2025 | → |
| Shared Genetic Architecture Between Atopic Dermatitis and Autoimmune Diseases. | Lazanas P et al. | — | 2025 | → |
| Shared Genetic Architecture Between Psychiatric Disorders and Keratoconus: Insights From a Large-Scale Genome-Wide Cross-Trait Analysis. | Li G et al. | — | 2025 | → |
| Shared genetic architecture between stroke and blood lipids: a large-scale genome-wide cross-trait analysis. | Bai W et al. | — | 2025 | → |
| Shared genetic associations between CHA<sub>2</sub>DS<sub>2</sub>-VASc score and cardio-embolic stroke: Insights from mendelian randomization based bioinformatics analysis. | Yuan K et al. | — | 2025 | → |
| Single-cell transcriptome atlas and genome-wide Mendelian randomization reveal chemokine involvement in diverse immune cells in type 2 diabetes. | Liu Y et al. | — | 2025 | → |
| Sjögren's syndrome is associated with a reduction in the surface area of the right caudal anterior cingulate gyrus. | Wang P et al. | — | 2025 | → |
| Sleep disorders and aging: Mendelian randomization analysis of epigenetic and frailty markers. | Zhang Z et al. | — | 2025 | → |
| Sleep Traits and Risk of Epilepsy: A Bidirectional and Multivariable Two-Sample Mendelian Randomization Study. | Zhu Y et al. | — | 2025 | → |
| Smoking exposure and cervical cancer risk: Integrating observational and genetic evidence. | Su L et al. | — | 2025 | → |
| Socioeconomic status, individual behaviors and the risk of aneurysmal subarachnoid hemorrhage: a Mendelian randomization study. | Luo S et al. | — | 2025 | → |
| Specific plasma lipid species in children are causally associated with kawasaki disease: a mendelian randomization analysis. | Zhen C et al. | — | 2025 | → |
| Statins as a risk factor for anaemia: Evidence from genetic and epidemiological data. | Liu Z et al. | — | 2025 | → |
| Strengthening the reporting of observational studies in epidemiology using Mendelian randomization (STROBE-MR): a Korean translation of explanation and elaboration. | Skrivankova VW et al. | — | 2025 | → |
| Sugar consumption and its role in dental caries: Insights from a 2-sample Mendelian randomization study. | Lim SW et al. | — | 2025 | → |
| Synergistic Effects of Dietary Protein and Vitamin E Intake on Reducing Metabolic-Associated Fatty Liver Disease Risk: Insights From NHANES [2017-2023] and Mendelian Randomization Study. | Wu W et al. | — | 2025 | → |
| Systematic genetic investigation on relative macronutrient intake, circulating metabolic biomarkers and the risk of autoimmune diseases. | Zheng S et al. | — | 2025 | → |
| Systolic and diastolic blood pressure, abdominal obesity, and alcohol consumption contribute to the risk of hypertrophic and dilated cardiomyopathies in European and East Asian populations. | Zhang W et al. | — | 2025 | → |
| The association between chronic liver disease and osteoporosis in East Asian populations: a bidirectional Mendelian randomization study. | Wang Z et al. | — | 2025 | → |
| The association between diet and bladder cancer risk: a two-sample mendelian randomization. | Dai YN et al. | — | 2025 | → |
| The association between maternal smoking and the risk of kidney diseases in offspring: A Mendelian randomization analysis based on large-scale GWAS. | Kang S et al. | — | 2025 | → |
| The association between sedentary behavior and infertility: a population-based cross-sectional observational study and Mendelian randomization analysis. | Wang Y et al. | — | 2025 | → |
| The association between white blood cell count and relative risk of non-small cell lung cancer. | Yang X et al. | — | 2025 | → |
| The Associations of General, Central, Visceral Obesity, and Body Fat Percentage with Cognitive Impairment in the Elderly: Meta-analysis and Mendelian Randomization Study. | Lu D et al. | — | 2025 | → |
| The brief resilience scale: a genome-wide association study in the UK Biobank. | Cornelis MC et al. | — | 2025 | → |
| The Casual Associations Between Brain Functional Networks and Fibromyalgia: A Large-Scale Genetic Correlation and Mendelian Randomization Study. | Hu Y et al. | — | 2025 | → |
| The causal association between insomnia and cognitive decline: A 2-sample, 2-step multivariable Mendelian randomization study. | Wang Z et al. | — | 2025 | → |
| The Causal Association between Total Bilirubin, Direct Bilirubin, and Ulcerative Colitis: A Two-Sample Mendelian Randomization Study. | Zhu X et al. | — | 2025 | → |
| The causal associations of 25(OH)D and its metabolites with oropharyngeal cancer risk: a Mendelian randomization study. | Yu Y et al. | — | 2025 | → |
| The Causal Correlation Between Gastroesophageal Reflux Disease and Chronic Widespread Pain: A Bidirectional Mendelian Randomization Study. | Chen M et al. | — | 2025 | → |
| The Causal Effect of Social Isolation on Cannabis Use Disorder and the Mediating Role of Depression: Evidence From a Mendelian Randomization Study. | Ma T | — | 2025 | → |
| The Causal Effects Between Circulating Inflammatory Proteins and Osteoarthritis: A Mendelian Randomization and Transcriptomic Analysis. | Lin S et al. | — | 2025 | → |
| The causality between chronic rhinosinusitis and inflammatory bowel disease: A bidirectional 2-sample Mendelian randomization analysis. | Liu Z et al. | — | 2025 | → |
| The causal links between gut microbiota and both acute and chronic renal failure: A two-sample mendelian randomization study. | Yang W | — | 2025 | → |
| The causal relationship between blood cell traits and aging: a Mendelian randomization study. | Chen P et al. | — | 2025 | → |
| The causal relationship between body mass index and perianal abscess: a Mendelian randomization study. | Wu L et al. | — | 2025 | → |
| The causal relationship between chronic obstructive pulmonary disease and Barrett's esophagitis: A two-sample Mendelian randomization study. | Yi N et al. | — | 2025 | → |
| The causal relationship between circulating inflammatory proteins, gut microbiotas, immune cells and leukemia: a bidirectional Mendelian randomization study. | Zhu L et al. | — | 2025 | → |
| The causal relationship between enlarged perivascular spaces and intracerebral hemorrhage: A 2-sample Mendelian randomization study. | Yan W et al. | — | 2025 | → |
| The causal relationship between gut microbiome composition and Alzheimer’s disease: A two-sample Mendelian randomization analysis | Monaghan G et al. | — | 2025 | — |
| The Causal Relationships Between Inflammatory Proteins, Brain Structure, and Psychiatric Disorders: A Two-Step Mendelian Randomization Analysis. | Zhao L et al. | — | 2025 | → |
| The crucial role of immune factors in susceptibility to SARS-CoV-2 infection and severity of COVID-19. | Yu XH et al. | — | 2025 | → |
| The "double-edged sword" effect of non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of endometriosis (EMS). | Shi Z et al. | — | 2025 | → |
| The Effect of Epigenetic Age Acceleration on Atopic Dermatitis: A Mendelian Randomization Study. | Xin Y et al. | — | 2025 | → |
| The Genetic Association Between Prescription Pain Medication Use and the Risk for Fibromyalgia: A Bidirectional and Multivariable Mendelian Randomization Analysis. | Zhou G et al. | — | 2025 | → |
| The gut microbiota, circulating metabolites, immune cells, and pancreatitis risk: Evidence from a bidirectional two-sample Mendelian randomization study and mediation analysis. | Zeng YZ et al. | — | 2025 | → |
| The Impact of Age at First Sexual Intercourse on Female Reproductive Disorders: A Mendelian Randomized Study. | Xin X et al. | — | 2025 | → |
| The impact of beverage consumption on chronic renal failure risk and the mediation of serum metabolites: based on Mendelian randomization study. | Wei Z et al. | — | 2025 | → |
| The Impact of Childhood Obesity on Adult Dental Caries: A Mendelian Randomization Study. | Kim YW et al. | — | 2025 | → |
| The Inflammatory-Immune Axis in Thyroid Disease: A Mendelian Randomization Study. | Pan T et al. | — | 2025 | → |
| The Interrelationship between Preconception Folate Nutritional Intake and Child Genetic Liability in the Risk of Childhood Acute Lymphoblastic Leukemia. | Xiang Y et al. | — | 2025 | → |
| The lactylation-immune regulatory axis: a potential therapeutic target for migraine prevention and treatment. | Wang L et al. | — | 2025 | → |
| The mechanisms of kidney-lung interactions in chronic kidney disease-associated pulmonary diseases: A two-sample Mendelian randomization study. | Yang S et al. | — | 2025 | → |
| The mediating role of blood metabolites in the association between myocardial infarction and cancer risk: An observational and mendelian randomization analysis. | Zhu J et al. | — | 2025 | → |
| The Mediating Role of Plasma Inflammatory Proteins in Gut Microbiota-Driven Valvular Heart Disease: A Mendelian Randomization Study. | Zhao J et al. | — | 2025 | → |
| The Mediation of Circulating Inflammatory Proteins in the Causal Pathway From Immune Cells to Delirium. | Liu T et al. | — | 2025 | → |
| The paradox of SGLT2 inhibitors in heart failure: Caution with drug target Mendelian randomization. | Huang H et al. | — | 2025 | → |
| The Persistent Threat of Chronic Inflammation on the Mortality Among Cervical Cancer Survivors: A Mendelian Randomization and Machine Learning Analysis Using UK Biobank and Chinese Cohort Data. | Wang J et al. | — | 2025 | → |
| The phenotypic and genetic association between endometriosis and immunological diseases. | Shigesi N et al. | — | 2025 | → |
| The potential causal relationship between fat mass in different body areas and low back pain: Findings from NHANES and Mendelian randomization studies. | Yang J et al. | — | 2025 | → |
| The Relationship Between Hypothyroidism and Pneumonia and Possible Prevention and Treatment Measures. | Hao Y et al. | — | 2025 | → |
| The relationship between insomnia and multiple gastrointestinal disorders: a Mendelian randomization study. | Yu J et al. | — | 2025 | → |
| The Role of Energy Homeostasis in Depression Pathophysiology and Its Heterogeneity. | Pistis G et al. | — | 2025 | → |
| The role of gut microbiota and plasma metabolites in osteoporosis: Insights from Mendelian randomization analysis. | Zhu W et al. | — | 2025 | → |
| The Role of Inflammatory Cytokines in the Causal Pathway From Gut Microbiota to Sjögren's Syndrome: Evidence From Mendelian Randomization. | Zhao J et al. | — | 2025 | → |
| The Role of Metabolites in CSF on NAFLD Development: A Mendelian Randomisation Analysis. | Liang F et al. | — | 2025 | → |
| The Role of Mitochondrial DNA Copy Number in Neurodevelopmental Disorders: A Bidirectional Two-Sample Mendelian Randomization Study. | Qiu X et al. | — | 2025 | → |
| The role of sleep traits in prostate, endometrial, and epithelial ovarian cancers: An observational and Mendelian randomisation study. | Chalitsios CV et al. | — | 2025 | → |
| The shared genetic architecture between schizophrenia and common peripheral organ imaging phenotypes. | Xie Y et al. | — | 2025 | → |
| The shared genetic structure and causal analysis between frailty and suicide. | Deng S et al. | — | 2025 | → |
| Thyroid disease and breast cancer, benign breast neoplasm: a two-sample Mendelian randomization study. | Wang B et al. | — | 2025 | → |
| Thyroid disorders and pregnancy loss: a bidirectional mendelian randomization exploration. | Chen P et al. | — | 2025 | → |
| Thyroid disorders as potential causal factors for preeclampsia: A two-sample bidirectional mendelian randomization study. | Zhan F et al. | — | 2025 | → |
| Thyroiditis and human blood metabolites: A mendelian randomization study. | Shao L et al. | — | 2025 | → |
| To explore the association between the neutrophil percentage to albumin ratio and low bone mineral density/osteoporosis based on NHANES 2011-2018. | Liu T et al. | — | 2025 | → |
| Toxic effect of carbon monoxide and 41 inflammatory cytokines: A bidirectional 2-sample Mendelian randomization study. | Yang H et al. | — | 2025 | → |
| Trends in Mendelian randomization in neurological disease research: a bibliometric analysis. | Yin S et al. | — | 2025 | → |
| Triangulation evidence for the causal effect of monocytes on pulmonary artery hypertension: a Mendelian randomization study and results from NHANES. | Liu Z et al. | — | 2025 | → |
| Two Birds With One Stone: The Protective Role of the Antidiabetic Drug Sodium-Glucose Cotransporter-2 Inhibitor in Neurodegenerative Diseases. | Zhang L et al. | — | 2025 | → |
| Two-Sample Network Mendelian Randomization and Single-Cell Analysis Reveal the Causal Associations and Underlying Mechanisms Between Antihypertensive Drugs and Kidney Cancer. | Deng R et al. | — | 2025 | → |
| Ubiquitin-related Protein IFNGR1 as Causal Factor and Drug Target for Keloids: A Mendelian Randomization Analysis. | Nurzat Y et al. | — | 2025 | → |
| UDP-Glucose Ceramide Glucosyltransferase Inhibition, Immune Cell Mediation, and Endometriosis Risk: A Mendelian Randomization Study. | Xue L et al. | — | 2025 | → |
| Uncovering the gut microbiota's role in temporomandibular joint disorders: A bidirectional Mendelian randomization study. | Ni T et al. | — | 2025 | → |
| Understanding the alcohol harm paradox: A multivariable mendelian randomization approach. | Sawyer G et al. | — | 2025 | → |
| Unique association of COVID-19 with increased risk of aplastic anemia among various viruses: insights from a two-sample Mendelian randomization study. | Zou J et al. | — | 2025 | → |
| Unraveling drug resistance mechanisms in testicular cancer through immune cell phenotypes: a bidirectional Mendelian randomization analysis revealing novel therapeutic targets. | Xiao L et al. | — | 2025 | → |
| Unraveling the causal landscape of intervertebral disc degeneration: A Mendelian randomization analysis of 108 traits. | Zeng B et al. | — | 2025 | → |
| Unraveling the causal link between immune cells and temporomandibular disorders: A Mendelian randomization analysis. | Zhang X et al. | — | 2025 | → |
| Unraveling the causal link between lipidomes and unstable angina pectoris: A Mendelian randomization analysis. | Pan W et al. | — | 2025 | → |
| Unraveling the causal nexus of cathepsins and rheumatoid arthritis: Insights from a two-sample Mendelian randomization framework. | Zhang H et al. | — | 2025 | → |
| Unraveling the Interplay Between Alcohol, Immunity, and Gastric Cancer: A Genomic Approach. | He KJ et al. | — | 2025 | → |
| Unraveling the link between inflammatory bowel disease and perianal abscess: insights from bidirectional and multivariable Mendelian randomization study. | Zhu H et al. | — | 2025 | → |
| Unraveling the link: Is Parkinson's disease a causal factor for glaucoma? Insights from Mendelian randomization. | Bin Lin MM et al. | — | 2025 | → |
| Unravelling the causal link between gut microbiota and acne risk using a genetic approach. | Cao F et al. | — | 2025 | → |
| Unveiling causal links between serum amino acid levels and risk of hepatobiliary neoplasms by Mendelian randomization study. | Zhai A et al. | — | 2025 | → |
| Unveiling CTRB2, RSPO3, KLOTB, and ROR1 as obesity-pancreatic disease association proteins: a comprehensive Mendelian randomization study. | Zhou C et al. | — | 2025 | → |
| Unveiling the Causal Relationship Between Osteoporosis and Circulating Metabolites from a Genetic Perspective. | Wan P et al. | — | 2025 | → |
| Unveiling the Causal Roles of the Oral Microbiome-Host Metabolism-Inflammation Axis in Periodontitis: A Mendelian Randomisation Study. | Zhao Z et al. | — | 2025 | → |
| Unveiling the diagnostic and causal role of hyperlipidemia- and lipophagy-associated genes PLAUR, IVNS1ABP, and QKI in acute myocardial infarction. | Zou JH et al. | — | 2025 | → |
| Unveiling the enigma: Investigating the controversy surrounding mitochondrial DNA copy number and gastric cancer using Mendelian randomization analysis. | Zhou J et al. | — | 2025 | → |
| Unveiling the genetic biomarkers for ageing: evidence from a large sample genome-wide association study and in vivo validation. | Cai Z et al. | — | 2025 | → |
| Unveiling the genetic overlap and causal links between gastroesophageal reflux disease and asthma. | Zhang Y et al. | — | 2025 | → |
| Unveiling the Role of Cathepsins on Lung Function in Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Analysis. | Zhang X et al. | — | 2025 | → |
| Use of bidirectional Mendelian randomization to unveil the association between antibody-mediated immune responses to infectious agents and allergic rhinitis. | Cao W et al. | — | 2025 | → |
| Use of bidirectional Mendelian randomization to unveil the association of Helicobacter pylori infection and pancreatic cancer. | Hu J et al. | — | 2025 | → |
| Utilising genomic association data for causal inference in anorexia nervosa. | Adams DM et al. | — | 2025 | → |
| Vitamin A and vitamin B12 levels and coronary artery atherosclerosis: Univariate and multivariate Mendelian randomization analysis. | Huang L et al. | — | 2025 | → |
| What comes first: Heart rate variability changes or insomnia? A causal investigation using Mendelian randomization. | Yan B et al. | — | 2025 | → |
| Widespread but moderate genetic overlap between circulating polyunsaturated fatty acids and brain disorders. | Xu H et al. | — | 2025 | → |
| Will diabetes mellitus induce aplastic anemia by immune factors?: A two-sample and mediation Mendelian randomization study. | Zhong C et al. | — | 2025 | → |