Acetylcholine in mind: a neurotransmitter correlate of consciousness?
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The cholinergic system is one of the most important modulatory neurotransmitter systems in the brain and controls activities that depend on selective attention, which are an essential component of conscious awareness. Psychopharmacological and pathological evidence supports the concept of a 'cholinergic component' of conscious awareness. Drugs that antagonize muscarinic receptors induce hallucinations and reduce the level of consciousness, while the nicotinic receptor is implicated as being involved in the mechanism of action of general (inhalational) anaesthetics. In degenerative diseases of the brain, alterations in consciousness are associated with regional deficits in the cholinergic system. In Alzheimer's disease (AD), there is a loss of explicit (more than implicit) memory and hypoactivity of cholinergic projections to the hippocampus and cortex, while the visual hallucinations experienced by subjects with Dementia with Lewy bodies (DLB) are associated with reductions in neocortical ACh-related activity. In Parkinson's disease, the additional loss of pedunculopontine cholinergic neurones, which control REM (rapid eye movement) sleep or dreaming, is likely to contribute to REM abnormalities, which also occur in DLB. Widespread basal-forebrain and rostral brainstem cholinergic pathways, which include converging projections to the thalamus, appear to be located strategically for generating and integrating conscious awareness. Alleviation of a range of cognitive and non-cognitive symptoms by drugs that modulate the cholinergic system, which are being developed for the treatment of AD and related disorders, could be caused by changes in consciousness.
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| Neurophysiological insights into the pathophysiology of REM sleep behavior disorders: a review. | Nardone R et al. | — | 2013 | → |
| Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice. | Rajasekar N et al. | — | 2013 | → |
| Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex. | Yang Y et al. | — | 2013 | → |
| pH sensing characteristics and biosensing application of solution-gated reduced graphene oxide field-effect transistors. | Sohn IY et al. | — | 2013 | → |
| Scopolamine modulates paternal parental retrieval behavior in mice induced by the maternal mate. | Fujimoto H et al. | — | 2013 | → |
| Short- and long-term habituation of auditory event-related potentials in the rat. | Gurevicius K et al. | — | 2013 | → |
| The anticipatory proportion as an indicator of language impairment in early-stage cognitive disorder in the elderly. | Wutzler A et al. | — | 2013 | → |
| A core process in receptor function, general anesthesia, sleep, and aging. | Kier LB et al. | — | 2012 | → |
| Cholinergic system function and cognition in mild cognitive impairment. | Haense C et al. | — | 2012 | → |
| Control of sleep and wakefulness. | Brown RE et al. | — | 2012 | → |
| Cortical afferent inhibition is reduced in patients with idiopathic REM sleep behavior disorder and cognitive impairment: a TMS study. | Nardone R et al. | — | 2012 | → |
| Early memory deficits precede plaque deposition in APPswe/PS1dE9 mice: involvement of oxidative stress and cholinergic dysfunction. | Zhang W et al. | — | 2012 | → |
| Early visuospatial deficits predict the occurrence of visual hallucinations in autopsy-confirmed dementia with Lewy bodies. | Hamilton JM et al. | — | 2012 | → |
| Event-Related Oscillations in Alcoholism Research: A Review. | Pandey AK et al. | — | 2012 | → |
| GABAA agonist reduces visual awareness: a masking-EEG experiment. | van Loon AM et al. | — | 2012 | → |
| Muscarinic receptors: their roles in disorders of the central nervous system and potential as therapeutic targets. | Scarr E | — | 2012 | → |
| Neuronal correlates to consciousness. The "Hall of Mirrors" metaphor describing consciousness as an epiphenomenon of multiple dynamic mosaics of cortical functional modules. | Agnati LF et al. | — | 2012 | → |
| Organization of the cholinergic systems in the brain of two lungfishes, Protopterus dolloi and Neoceratodus forsteri. | López JM et al. | — | 2012 | → |
| Pareidolias: complex visual illusions in dementia with Lewy bodies. | Uchiyama M et al. | — | 2012 | → |
| Population spikes in cortical networks during different functional states. | Mark S et al. | — | 2012 | → |
| Prefrontal gray matter morphology mediates the association between serum anticholinergicity and cognitive functioning in early course schizophrenia. | Wojtalik JA et al. | — | 2012 | → |
| Proteasome inhibition leads to early loss of synaptic proteins in neuronal culture. | Bajic N et al. | — | 2012 | → |
| Staging of the cognitive decline in Alzheimer's disease: insights from a detailed neuropsychological investigation of mild cognitive impairment and mild Alzheimer's disease. | Carter SF et al. | — | 2012 | → |
| The pedunculopontine nucleus is related to visual hallucinations in Parkinson's disease: preliminary results of a voxel-based morphometry study. | Janzen J et al. | — | 2012 | → |
| 24-month effect of smoking cessation on cognitive function and brain structure in later life. | Almeida OP et al. | — | 2011 | → |
| Alzheimer's disease, anesthesia and the cholinergic system. | Kapoor MC | — | 2011 | → |
| Biperiden-induced delirium in an adolescent patient. | Wang LJ et al. | — | 2011 | → |
| Drugs with anticholinergic properties: a current perspective on use and safety. | Gerretsen P et al. | — | 2011 | → |
| ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor. | Saxena G et al. | — | 2011 | → |
| Lesion of cholinergic neurons in nucleus basalis enhances response to general anesthetics. | Leung LS et al. | — | 2011 | → |
| M1 and M4 receptors modulate hippocampal pyramidal neurons. | Dasari S et al. | — | 2011 | → |
| Modes and models of forebrain cholinergic neuromodulation of cognition. | Hasselmo ME et al. | — | 2011 | → |
| Neurophysiology of Nicotine Addiction. | Dani JA et al. | — | 2011 | → |
| Norepinephrine infusion into nucleus basalis elicits microarousal in desflurane-anesthetized rats. | Pillay S et al. | — | 2011 | → |
| Purple rice berry is neuroprotective and enhances cognition in a rat model of Alzheimer's disease. | Pannangrong W et al. | — | 2011 | → |
| Revisiting the cholinergic hypothesis of behavioral and psychological symptoms in dementia of the Alzheimer's type. | Pinto T et al. | — | 2011 | → |
| Reward, addiction, withdrawal to nicotine. | De Biasi M et al. | — | 2011 | → |
| Scutellarin protects against Aβ-induced learning and memory deficits in rats: involvement of nicotinic acetylcholine receptors and cholinesterase. | Guo LL et al. | — | 2011 | → |
| Sex differences in the septo-hippocampal cholinergic system in rats: behavioral consequences. | Mitsushima D | — | 2011 | → |
| Specific α4β2 nicotinic acetylcholine receptor binding of [F-18]nifene in the rhesus monkey. | Hillmer AT et al. | — | 2011 | → |
| The basal forebrain cholinergic system in aging and dementia. Rescuing cholinergic neurons from neurotoxic amyloid-β42 with memantine. | Nyakas C et al. | — | 2011 | → |
| The central role of 5-HT6 receptors in modulating brain neurochemistry. | Dawson LA | — | 2011 | → |
| The interplay of cholinergic function, attention, and falls in Parkinson's disease. | Yarnall A et al. | — | 2011 | → |
| The in vivo neurochemistry of the brain during general anesthesia. | Müller CP et al. | — | 2011 | → |
| Water chreodes and the mechanisms of ligand diffusion, general anesthesia, and sleep. | Kier LB | — | 2011 | → |
| Anti-inflammatory and antioxidant activities of Jungia paniculata. | Casado R et al. | — | 2010 | → |
| Cholinergic neuromodulation controls directed temporal communication in neocortex in vitro. | Roopun AK et al. | — | 2010 | → |
| Cognitive enhancement as a pharmacotherapy target for stimulant addiction. | Sofuoglu M | — | 2010 | → |
| [Dreaming is a hypnic state of consciousness: getting rid of the Goblot hypothesis and its modern avatars]. | Guénolé F et al. | — | 2010 | → |
| Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines. | Sarachana T et al. | — | 2010 | → |
| Measurement of orexin (hypocretin) and substance P effects on constitutively active inward rectifier K(+) channels in brain neurons. | Nakajima Y et al. | — | 2010 | → |
| Metabolic activity in the brain of juvenile and adult rats with a neonatal ventral hippocampal lesion. | François J et al. | — | 2010 | → |
| Nicotine induction of theta frequency oscillations in rodent hippocampus in vitro. | Lu CB et al. | — | 2010 | → |
| Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity. | Kamat PK et al. | — | 2010 | → |
| Role of the central ascending neurotransmitter systems in the psychostimulant effects of caffeine. | Ferré S | — | 2010 | → |
| Sex steroids and acetylcholine release in the hippocampus. | Mitsushima D | — | 2010 | → |
| Temporal dynamics of distinct CA1 cell populations during unconscious state induced by ketamine. | Kuang H et al. | — | 2010 | → |
| To what extent do neurobiological sleep-waking processes support psychoanalysis? | Gottesmann C | — | 2010 | → |
| Action of estrogen on survival of basal forebrain cholinergic neurons: promoting amelioration. | Abrahám IM et al. | — | 2009 | → |
| Activational and organisational effects of gonadal steroids on sex-specific acetylcholine release in the dorsal hippocampus. | Mitsushima D et al. | — | 2009 | → |
| Advances in the design of 5-HT6 receptor ligands with therapeutic potential. | Witty D et al. | — | 2009 | → |
| An electrospray ionization mass spectrometric study of the interactions between crown ethers and tetramethylammonium(-phosphonium) cations. | Frański R | — | 2009 | → |
| Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway. | Pavlov VA et al. | — | 2009 | → |
| Cholinergic functioning in stimulant addiction: implications for medications development. | Sofuoglu M et al. | — | 2009 | → |
| Choline transporter gene variation is associated with attention-deficit hyperactivity disorder. | English BA et al. | — | 2009 | → |
| Drugs with anticholinergic properties: a potential risk factor for psychosis onset in Alzheimer's disease? | Cancelli I et al. | — | 2009 | → |
| Evolution of the human CNS cholineric system: has this resulted in the emergence of psychiatric disease? | Dean B | — | 2009 | → |
| Functional involvement of central cholinergic circuits and visual hallucinations in Parkinson's disease. | Manganelli F et al. | — | 2009 | → |
| Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET. | Shimada H et al. | — | 2009 | → |
| Protective effect of stilbenes containing extract-fraction from Cajanus cajan L. on Abeta(25-35)-induced cognitive deficits in mice. | Ruan CJ et al. | — | 2009 | → |
| Quality of life as an outcome in Alzheimer's disease and other dementias--obstacles and goals. | Riepe MW et al. | — | 2009 | → |
| Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-(11)C-methoxy]donepezil. | Hiraoka K et al. | — | 2009 | → |
| Rivastigmine in Parkinson's disease dementia. | Chitnis S et al. | — | 2009 | → |
| Role of the cholinergic system in the pathology and treatment of schizophrenia. | Scarr E et al. | — | 2009 | → |
| Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation. | Ma L et al. | — | 2009 | → |
| Typical and atypical antipsychotics alter acetylcholinesterase activity and ACHE expression in zebrafish (Danio rerio) brain. | Seibt KJ et al. | — | 2009 | → |
| 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease. | Upton N et al. | — | 2008 | → |
| Acetylcholine esterase activity in mild cognitive impairment and Alzheimer's disease. | Herholz K | — | 2008 | → |
| Acetylcholine receptors in dementia and mild cognitive impairment. | Sabri O et al. | — | 2008 | → |
| A review of brain oscillations in cognitive disorders and the role of neurotransmitters. | Başar E et al. | — | 2008 | → |
| Cholinesterase inhibitors for delirium: what is the evidence? | Mukadam N et al. | — | 2008 | → |
| Coexposure of neonatal mice to a flame retardant PBDE 99 (2,2',4,4',5-pentabromodiphenyl ether) and methyl mercury enhances developmental neurotoxic defects. | Fischer C et al. | — | 2008 | → |
| Cognition enhancers between treating and doping the mind. | Lanni C et al. | — | 2008 | → |
| Critical Evaluation of Acetylcholine Determination in Rat Brain Microdialysates using Ion-Pair Liquid Chromatography with Amperometric Detection. | De Bundel D et al. | — | 2008 | → |
| Deficits of the cholinergic system in early AD. | Herholz K et al. | — | 2008 | → |
| Degeneration of cholinergic rat basal forebrain neurons after experimental subarachnoid hemorrhage. | Löhr M et al. | — | 2008 | → |
| Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice. | Saxena G et al. | — | 2008 | → |
| From event-related potential to oscillations: genetic diathesis in brain (dys)function and alcohol dependence. | Rangaswamy M et al. | — | 2008 | → |
| In vivo imaging of neurotransmission and brain receptors in dementia. | Pappatà S et al. | — | 2008 | → |
| MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats. | Bessho T et al. | — | 2008 | → |
| Neonatal exposure to deca-brominated diphenyl ether (PBDE 209) causes dose-response changes in spontaneous behaviour and cholinergic susceptibility in adult mice. | Johansson N et al. | — | 2008 | → |
| Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice. | Johansson N et al. | — | 2008 | → |
| Neurocognitive effects of ziprasidone and related factors in patients with chronic schizophrenia undergoing usual care: a 12-month, open-label, flexible-dose, naturalistic observational trial. | Gibel A et al. | — | 2008 | → |
| Neurodegeneration and the structure of time: clinical evidence for philosophical reasoning. | Förstl H | — | 2008 | → |
| Neurokinin-1 receptors in cholinergic neurons of the rat ventral pallidum have a predominantly dendritic distribution that is affected by apomorphine when combined with startle-evoking auditory stimulation. | Mengual E et al. | — | 2008 | → |
| Nicotinic receptors containing the alpha7 subunit: a model for rational drug design. | Sharma G et al. | — | 2008 | → |
| Nicotinic Receptors: Role in Addiction and Other Disorders of the Brain. | Sharma G et al. | — | 2008 | → |
| Pathophysiology and treatment of psychosis in Parkinson's disease: a review. | Zahodne LB et al. | — | 2008 | → |
| Role of the central cholinergic system in the therapeutics of schizophrenia. | Terry AV | — | 2008 | → |
| Time-dependent alterations of cholinergic markers after experimental traumatic brain injury. | Donat CK et al. | — | 2008 | → |
| Uncovering genes for cognitive (dys)function and predisposition for alcoholism spectrum disorders: a review of human brain oscillations as effective endophenotypes. | Rangaswamy M et al. | — | 2008 | → |
| Vesicular acetylcholine transporter (VAChT) in the brain of spontaneously hypertensive rats (SHR): effect of treatment with an acetylcholinesterase inhibitor. | Tayebati SK et al. | — | 2008 | → |
| AC260584 (4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one), a selective muscarinic M1 receptor agonist, increases acetylcholine and dopamine release in rat medial prefrontal cortex and hippocampus. | Li Z et al. | — | 2007 | → |
| A new treatment for hypoxic brain injury? | Flood P | — | 2007 | → |
| Cholinergic dysfunction in temporal lobe epilepsy. | Friedman A et al. | — | 2007 | → |
| Cognitive deficits in schizophrenia: focus on neuronal nicotinic acetylcholine receptors and smoking. | Ochoa EL et al. | — | 2007 | → |
| Cognitive functioning in late life: the impact of moderate alcohol consumption. | McGuire LC et al. | — | 2007 | → |
| Deficits in acetylcholine homeostasis, receptors and behaviors in choline transporter heterozygous mice. | Bazalakova MH et al. | — | 2007 | → |
| [Delirium with dementia]. | Kratz T | — | 2007 | → |
| Delta and theta oscillations as risk markers in adolescent offspring of alcoholics. | Rangaswamy M et al. | — | 2007 | → |
| Dementia with Lewy bodies. | Ferman TJ et al. | — | 2007 | → |
| Effects of typical and atypical antipsychotic drugs on rat brain muscarinic receptors. | Zavitsanou K et al. | — | 2007 | → |
| Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model. | Semmler A et al. | — | 2007 | → |
| Muscarinic receptor dependent long-term depression in rat visual cortex is PKC independent but requires ERK1/2 activation and protein synthesis. | McCoy PA et al. | — | 2007 | → |
| New approaches to understanding hallucinations in Parkinson's disease: phenomenology and possible origins. | Onofrj M et al. | — | 2007 | → |
| Physostigmine reverses cognitive dysfunction caused by moderate hypoxia in adult mice. | Bekker A et al. | — | 2007 | → |
| Reward prediction error computation in the pedunculopontine tegmental nucleus neurons. | Kobayashi Y et al. | — | 2007 | → |
| Selective disarrangement of the rostral telencephalic cholinergic system in heterozygous reeler mice. | Sigala S et al. | — | 2007 | → |
| Sex difference in the 24-h acetylcholine release profile in the premotor/supplementary motor area of behaving rats. | Takase K et al. | — | 2007 | → |
| Subjectively reported sleep quality and excessive daytime somnolence in Parkinson's disease with and without dementia, dementia with Lewy bodies and Alzheimer's disease. | Boddy F et al. | — | 2007 | → |
| Systemic and brain metabolic dysfunction as a new paradigm for approaching Alzheimer's dementia. | Giordano V et al. | — | 2007 | → |
| Tabernaemontana divaricata extract inhibits neuronal acetylcholinesterase activity in rats. | Chattipakorn S et al. | — | 2007 | → |
| The neurobiological characteristics of rapid eye movement (REM) sleep are candidate endophenotypes of depression, schizophrenia, mental retardation and dementia. | Gottesmann C et al. | — | 2007 | → |
| Towards a muscarinic hypothesis of schizophrenia. | Raedler TJ et al. | — | 2007 | → |
| A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine-acetylcholine synaptic balance. | Calabresi P et al. | — | 2006 | → |
| Alzheimer's disease and anaesthesia: implications for the central cholinergic system. | Fodale V et al. | — | 2006 | → |
| ApoE-epsilon 4-dependent association of the choline acetyltransferase gene polymorphisms (2384G>A and 1882G>A) with Alzheimer's disease. | Ahn Jo S et al. | — | 2006 | → |
| Binding properties of the cerebral alpha4beta2 nicotinic acetylcholine receptor ligand 2-[18F]fluoro-A-85380 to plasma proteins. | Sorger D et al. | — | 2006 | → |
| Biperiden-induced delirium model in rats: a behavioral and electroencephalographic study. | Tamura Y et al. | — | 2006 | → |
| Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody. | Bales KR et al. | — | 2006 | → |
| Cognitive decline correlates with neuropathological stage in Parkinson's disease. | Braak H et al. | — | 2006 | → |
| Do lesions involving the cortical cholinergic pathways help or hinder efficacy of donepezil in patients with Alzheimer's disease? | Fukui T et al. | — | 2006 | → |
| Dopaminergic dysbalance in distinct basal ganglia neurocircuits: implications for the pathophysiology of Parkinson's disease, schizophrenia and attention deficit hyperactivity disorder. | Mehler-Wex C et al. | — | 2006 | → |
| Effects of rivastigmine on cognitive function in patients with traumatic brain injury. | Silver JM et al. | — | 2006 | → |
| Genetic deletion of muscarinic M4 receptors is anxiolytic in the shock-probe burying model. | Degroot A et al. | — | 2006 | → |
| Genetics of human brain oscillations. | Begleiter H et al. | — | 2006 | → |
| Involvement of the GABAergic system in depressive symptoms of Alzheimer's disease. | Garcia-Alloza M et al. | — | 2006 | → |
| Looking back: corticothalamic feedback and early visual processing. | Cudeiro J et al. | — | 2006 | → |
| More attention must be paid: the neurobiology of attentional effort. | Sarter M et al. | — | 2006 | → |
| Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes. | George O et al. | — | 2006 | → |
| Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered. | Braak H et al. | — | 2006 | → |
| Thalamic nicotinic receptors implicated in disturbed consciousness in dementia with Lewy bodies. | Pimlott SL et al. | — | 2006 | → |
| The cholinergic system in Down's syndrome. | Fodale V et al. | — | 2006 | → |
| The dreaming sleep stage: a new neurobiological model of schizophrenia? | Gottesmann C | — | 2006 | → |
| The Ferrier Lecture 1998. The molecular biology of consciousness investigated with genetically modified mice. | Changeux JP | — | 2006 | → |
| The high-affinity choline transporter: a critical protein for sustaining cholinergic signaling as revealed in studies of genetically altered mice. | Bazalakova MH et al. | — | 2006 | → |
| The P300 component in patients with Alzheimer's disease and their biological children. | Ally BA et al. | — | 2006 | → |
| The role of the extrapersonal brain systems in religious activity. | Previc FH | — | 2006 | → |
| Time-dependent effects of haloperidol and ziprasidone on nerve growth factor, cholinergic neurons, and spatial learning in rats. | Terry AV et al. | — | 2006 | → |
| Ziprasidone-induced cognitive enhancement in schizophrenia: specificity or pseudospecificity? | Malhotra AK et al. | — | 2006 | → |
| 5-HT6 receptors: a novel target for cognitive enhancement. | Mitchell ES et al. | — | 2005 | → |
| Acetylcholine dynamically controls spatial integration in marmoset primary visual cortex. | Roberts MJ et al. | — | 2005 | → |
| Activation of nucleus basalis facilitates cortical control of a brain stem motor program. | Berg RW et al. | — | 2005 | → |
| An Os(II)--bisbipyridine--4-picolinic acid complex mediates the biocatalytic growth of au nanoparticles: optical detection of glucose and acetylcholine esterase inhibition. | Xiao Y et al. | — | 2005 | → |
| Apolipoprotein E and category fluency: evidence for reduced semantic access in healthy normal controls at risk for developing Alzheimer's disease. | Rosen VM et al. | — | 2005 | → |
| Brain 3D-SSP SPECT analysis in dementia with Lewy bodies, Parkinson's disease with and without dementia, and Alzheimer's disease. | Mito Y et al. | — | 2005 | → |
| Dementia associated with alcohol and other drug use. | Hulse GK et al. | — | 2005 | → |
| Direct detection of brain acetylcholine synthesis by magnetic resonance spectroscopy. | Katz-Brull R et al. | — | 2005 | → |
| Drugs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium. | Praticò C et al. | — | 2005 | → |
| Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies. | Teaktong T et al. | — | 2005 | → |
| N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors. | Li Z et al. | — | 2005 | → |
| Sleep, anesthesiology, and the neurobiology of arousal state control. | Lydic R et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
| Treatment of behavioural symptoms and dementia in Parkinson's disease. | Hanagasi HA et al. | — | 2005 | → |
| Treatment of dementia with Lewy bodies and Parkinson's disease dementia. | Poewe W | — | 2005 | → |
| Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection. | Sarter M et al. | — | 2005 | → |
| Visual dysfunction in Parkinson disease without dementia. | Uc EY et al. | — | 2005 | → |
| Adulthood nicotine treatment alleviates behavioural impairments in rats neonatally treated with quinpirole: possible roles of acetylcholine function and neurotrophic factor expression. | Brown RW et al. | — | 2004 | → |
| Alcohol, wine and mental health: focus on dementia and stroke. | Pinder RM et al. | — | 2004 | → |
| Brain inhibitory mechanisms involved in basic and higher integrated sleep processes. | Gottesmann C | — | 2004 | → |
| Cholinergic elements in the zebrafish central nervous system: Histochemical and immunohistochemical analysis. | Clemente D et al. | — | 2004 | → |
| Chronic ethanol consumption does not affect action of propofol on rat hippocampal acetylcholine release in vivo. | Inagawa G et al. | — | 2004 | → |
| Developmental origins of the age-related decline in cortical cholinergic function and associated cognitive abilities. | Sarter M et al. | — | 2004 | → |
| Differential effects of typical and atypical antipsychotics on nerve growth factor and choline acetyltransferase expression in the cortex and nucleus basalis of rats. | Parikh V et al. | — | 2004 | → |
| Distinct forms of cholinergic modulation in parallel thalamic sensory pathways. | Mooney DM et al. | — | 2004 | → |
| DLB fluctuations: specific features that reliably differentiate DLB from AD and normal aging. | Ferman TJ et al. | — | 2004 | → |
| Factors associated with complex visual hallucinations during antidepressant treatment. | Cancelli I et al. | — | 2004 | → |
| Functional nicotinic acetylcholine receptors on subplate neurons in neonatal rat somatosensory cortex. | Hanganu IL et al. | — | 2004 | → |
| Gamma EEG dynamics in neocortex and hippocampus during human wakefulness and sleep. | Cantero JL et al. | — | 2004 | → |
| Interaction between dinucleotide and nicotinic receptors in individual cholinergic terminals. | Díaz-Hernández M et al. | — | 2004 | → |
| Involvement of alpha6/alpha3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies: [(125)I]-alpha-conotoxin MII binding in the thalamus and striatum. | Ray M et al. | — | 2004 | → |
| Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition. | Jones KA et al. | — | 2004 | → |
| Loss of cortical acetylcholine enhances amphetamine-induced locomotor activity. | Mattsson A et al. | — | 2004 | → |
| Molecular and neuronal substrates for general anaesthetics. | Rudolph U et al. | — | 2004 | → |
| Muscarinic acetylcholine receptor stimulation induces expression of the activity-regulated cytoskeleton-associated gene (ARC). | Teber I et al. | — | 2004 | → |
| Neurochemistry of consciousness: cholinergic pathologies in the human brain. | Perry EK et al. | — | 2004 | → |
| Pedunculo-pontine control of visually guided saccades. | Kobayashi Y et al. | — | 2004 | → |
| PSD93 regulates synaptic stability at neuronal cholinergic synapses. | Parker MJ et al. | — | 2004 | → |
| Psychosis in Parkinson's disease. | Wint DP et al. | — | 2004 | → |
| Psychotic symptoms in Parkinson's disease: pathophysiology and management. | Bosboom JL et al. | — | 2004 | → |
| Randomized placebo-controlled trial of donepezil in cognitive impairment in Parkinson's disease. | Leroi I et al. | — | 2004 | → |
| Reduction in acetylcholine release in the hippocampus of dopamine D5 receptor-deficient mice. | Laplante F et al. | — | 2004 | → |
| Response-related fMRI of veridical and false recognition of words. | Heun R et al. | — | 2004 | → |
| Right prosubiculum amyloid plaque density correlates with anosognosia in Alzheimer's disease. | Marshall GA et al. | — | 2004 | → |
| Selective reduction in ventral hippocampal acetylcholine release in awake galanin-treated rats and galanin-overexpressing transgenic mice. | Laplante F et al. | — | 2004 | → |
| Sound sequence discrimination learning is dependent on cholinergic inputs to the rat auditory cortex. | Kudoh M et al. | — | 2004 | → |
| Structural determinants of the roles of acetylcholine in cerebral cortex. | Descarries L et al. | — | 2004 | → |
| The acetylcholinesterase inhibitors for treatment of cognitive and behavioral symptoms in dementia with Lewy bodies. | Simard M et al. | — | 2004 | → |
| The genetics of oscillations in the human brain. | Porjesz B et al. | — | 2004 | → |
| Treatment of opioid-induced delirium with acetylcholinesterase inhibitors: a case report. | Slatkin N et al. | — | 2004 | → |
| Amnesia induced by beta-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade. | Mazzola C et al. | — | 2003 | → |
| A novel method for noninvasive detection of neuromodulatory changes in specific neurotransmitter systems. | Alpert NM et al. | — | 2003 | → |
| Ca2+-dependent inward current induced by nicotinic receptor activation depends on Ca2+/calmodulin-CaMKII pathway in dopamine neurons. | Yamashita T et al. | — | 2003 | → |
| Cognitive, psychiatric and motor response to galantamine in Parkinson's disease with dementia. | Aarsland D et al. | — | 2003 | → |
| Drug treatment of REM sleep behavior disorders in dementia with Lewy bodies. | Massironi G et al. | — | 2003 | → |
| Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. | Tzavara ET et al. | — | 2003 | → |
| Individual differences in cognitive aging: implication of pregnenolone sulfate. | Mayo W et al. | — | 2003 | → |
| Modulatory action of acetylcholine on striatal neurons: microiontophoretic study in awake, unrestrained rats. | Windels F et al. | — | 2003 | → |
| Muscarinic and GABAA receptors modulate acetylcholine release in feline basal forebrain. | Vazquez J et al. | — | 2003 | → |
| Nitric oxide-mediated cortical activation: a diffuse wake-up system. | Mariño J et al. | — | 2003 | → |
| Perturbed signal transduction in neurodegenerative disorders involving aberrant protein aggregation. | Mattson MP et al. | — | 2003 | → |
| Pharmacological discrimination between muscarinic receptor signal transduction cascades with bethanechol chloride. | Liu L et al. | — | 2003 | → |
| Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors. | Gobert A et al. | — | 2003 | → |
| Pyridostigmine enhances glutamatergic transmission in hippocampal CA1 neurons. | Pavlovsky L et al. | — | 2003 | → |
| Rats living in small cages respond to restraint stress with adrenocortical corticosterone release but not with hippocampal acetylcholine release. | Mitsushima D et al. | — | 2003 | → |
| The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development. | Terry AV et al. | — | 2003 | → |
| 17beta-estradiol enhances cortical cholinergic innervation and preserves synaptic density following excitotoxic lesions to the rat nucleus basalis magnocellularis. | Horvath KM et al. | — | 2002 | → |
| Acute synaptic modulation by nicotinic agonists in developing cerebellar Purkinje cells of the rat. | Kawa K | — | 2002 | → |
| Alcohol consumption and risk of dementia: the Rotterdam Study. | Ruitenberg A et al. | — | 2002 | → |
| Cholinesterase-inhibitor therapy for dementia: novel clinical substrates and mechanisms for treatment response. | Kaufer DI | — | 2002 | → |
| Co-localisation of functional nicotinic and ionotropic nucleotide receptors in isolated cholinergic synaptic terminals. | Díaz-Hernández M et al. | — | 2002 | → |
| Complete deletion of the neurotrophin receptor p75NTR leads to long-lasting increases in the number of basal forebrain cholinergic neurons. | Naumann T et al. | — | 2002 | → |
| Contribution of pedunculopontine tegmental nucleus neurons to performance of visually guided saccade tasks in monkeys. | Kobayashi Y et al. | — | 2002 | → |
| Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia. | Dean B et al. | — | 2002 | → |
| Disturbances of consciousness in dementia with Lewy bodies associated with alteration in nicotinic receptor binding in the temporal cortex. | Ballard CG et al. | — | 2002 | → |
| Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons. | Krause M et al. | — | 2002 | → |
| Heteropterys aphrodisiaca (extract BST0298): a Brazilian plant that improves memory in aged rats. | Galvão SM et al. | — | 2002 | → |
| Metalearning and neuromodulation. | Doya K | — | 2002 | → |
| Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2. | McClatchy DB et al. | — | 2002 | → |
| Pharmacologic therapy of dementia with Lewy bodies. | Kaufer DI | — | 2002 | → |
| Regulatory mechanisms that govern nicotinic synapse formation in neurons. | Rosenberg MM et al. | — | 2002 | → |
| Sensory-motor gating and cognitive control by the brainstem cholinergic system. | Kobayashi Y et al. | — | 2002 | → |
| Sleep-wake mechanisms and drug discovery: sleep EEG as a tool for the development of CNS-acting drugs. | Staner L | — | 2002 | → |
| The neurochemistry of waking and sleeping mental activity: the disinhibition-dopamine hypothesis. | Gottesmann C | — | 2002 | → |
| The neurosteroid pregnenolone sulfate infused into the medial septum nucleus increases hippocampal acetylcholine and spatial memory in rats. | Darnaudéry M et al. | — | 2002 | → |
| Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors. | Changeux J et al. | — | 2001 | → |
| A quantum approach to visual consciousness. | Woolf NJ et al. | — | 2001 | → |
| Basal forebrain acetylcholine release during REM sleep is significantly greater than during waking. | Vazquez J et al. | — | 2001 | → |
| Brain aging research at the close of the 20th century: from bench to bedside. | Cidis Meltzer C et al. | — | 2001 | → |
| Cholinergic deficits in the brains of patients with parkinsonism-dementia complex of Guam. | Masliah E et al. | — | 2001 | → |
| Cholinergic nerve terminals establish classical synapses in the rat cerebral cortex: synaptic pattern and age-related atrophy. | Turrini P et al. | — | 2001 | → |
| Cholinergic systems and schizophrenia: primary pathology or epiphenomena? | Hyde TM et al. | — | 2001 | → |
| Dahl salt-sensitive and salt-resistant rats: examination of learning and memory performance, blood pressure, and the expression of central nicotinic acetylcholine receptors. | Terry AV et al. | — | 2001 | → |
| Dementia with Lewy bodies: clinical features and treatment. | Campbell S et al. | — | 2001 | → |
| Donepezil in the treatment of opioid-induced sedation: report of six cases. | Slatkin NE et al. | — | 2001 | → |
| Effect of acetylcholine on the temporary connections in neuronal populations of intact cortex and a neuronally isolated cortical strip. | Chizhenkova RA | — | 2001 | → |
| Laminar distribution of cholinergic- and serotonergic-dependent plasticity within kitten visual cortex. | Kojic L et al. | — | 2001 | → |
| Molecular ontogeny of major neurotransmitter receptor systems in the mammalian central nervous system: norepinephrine, dopamine, serotonin, acetylcholine, and glycine. | Rho JM et al. | — | 2001 | → |
| N-methyl-D-aspartate channel and consciousness: from signal coincidence detection to quantum computing. | Freitas da Rocha A et al. | — | 2001 | → |
| Pregnenolone sulfate and aging of cognitive functions: behavioral, neurochemical, and morphological investigations. | Mayo W et al. | — | 2001 | → |
| Src family kinase involvement in muscarinic receptor-induced tyrosine phosphorylation in differentiated SH-SY5Y cells. | Watcharasit P et al. | — | 2001 | → |
| Stroop interference and facilitation effects in first-episode schizophrenic patients. | Chen EY et al. | — | 2001 | → |
| Successful use of donepezil for the treatment of dementia with Lewy bodies. | Rojas-Fernandez CH | — | 2001 | → |
| What have we learned about cognition in myasthenia gravis?: a review of methods and results. | Paul RH et al. | — | 2001 | → |
| A comparison of sleep profiles in patients with dementia with lewy bodies and Alzheimer's disease. | Grace JB et al. | — | 2000 | → |
| A model for pleiotropic muscarinic potentiation of fast synaptic transmission. | Schobesberger H et al. | — | 2000 | → |
| A new look at the neuronal nicotinic acetylcholine receptor pharmacophore. | Curtis L et al. | — | 2000 | → |
| Central cholinergic depletion induced by 192 IgG-saporin alleviates the sedative effects of propofol in rats. | Pain L et al. | — | 2000 | → |
| Cholinergic innervation in adult rat cerebral cortex: a quantitative immunocytochemical description. | Mechawar N et al. | — | 2000 | → |
| Cholinergic modulation of cortical function: a hypothetical role in shifting the dynamics in cortical network. | Kimura F | — | 2000 | → |
| Distribution of choline acetyltransferase (ChAT) immunoreactivity in the brain of the adult trout and tract-tracing observations on the connections of the nuclei of the isthmus. | Pérez SE et al. | — | 2000 | → |
| Galantamine: a review of its use in Alzheimer's disease. | Scott LJ et al. | — | 2000 | → |
| Increased acetylcholine release in the rat medial prefrontal cortex during performance of a visual attentional task. | Passetti F et al. | — | 2000 | → |
| Localization of nicotinic receptor subunit mRNAs in monkey brain by in situ hybridization. | Quik M et al. | — | 2000 | → |
| Morphology and neurochemistry of two striatal neuronal subtypes expressing the GABA(A) receptor alpha3-subunit in the rat. | Rodríguez-Pallares J et al. | — | 2000 | → |
| Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61. | Albrecht C et al. | — | 2000 | → |
| Nicotinic receptor function: new perspectives from knockout mice. | Cordero-Erausquin M et al. | — | 2000 | → |
| Nicotinic receptors in human brain: topography and pathology. | Court JA et al. | — | 2000 | → |
| Quantifying fluctuation in dementia with Lewy bodies, Alzheimer's disease, and vascular dementia. | Walker MP et al. | — | 2000 | → |
| Quantitative autoradiographic distribution of gamma-hydroxybutyric acid binding sites in human and monkey brain. | Castelli MP et al. | — | 2000 | → |
| Receptor targeting and heterogeneity at interneuronal nicotinic cholinergic synapses in vivo. | Temburni MK et al. | — | 2000 | → |
| Sleep disturbance and nonmalignant chronic pain: a comprehensive review of the literature. | Menefee LA et al. | — | 2000 | → |
| Ultrastructural evidence for diffuse transmission by monoamine and acetylcholine neurons of the central nervous system. | Descarries L et al. | — | 2000 | → |
| Cholinergic correlates of consciousness: from mind to molecules. | Woolf NJ | — | 1999 | → |
| Cholinergic therapy for neuropsychiatric symptoms in neurologic disorders. | Kaufer DI | — | 1999 | → |
| Consciousness in mind: a correlate for ACh? | Hölscher C | — | 1999 | → |
| Magnetoencephalography of cognitive responses A sensitive method for the detection of age-related changes. | Boeijinga PH | — | 1999 | → |
| Neuropsychiatric aspects of Alzheimer's disease. | Ballard C et al. | — | 1999 | → |
| Tracking cholinergic pathways from psychological and chemical stressors to variable neurodeterioration paradigms. | Kaufer D et al. | — | 1999 | → |