Association of alcohol craving with alpha-synuclein (SNCA).
paper
Primary
Public
Unavailable
- Authors
- Foroud, Tatiana; Wetherill, Leah Flury; Liang, Tiebing; Dick, Danielle M; Hesselbrock, Victor; Kramer, John; Nurnberger, John; Schuckit, Marc; Carr, Lucinda; Porjesz, Bernice; Xuei, Xiaoling; Edenberg, Howard J
- Year
- 2007
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 17374032
- DOI
- 10.1111/j.1530-0277.2007.00337.x
BACKGROUND: Studies have found that genomic variation in the gene SNCA, which encodes the protein alpha-synuclein, may contribute to the variation in alcohol consumption in an inbred rat model of alcohol preference. Studies in humans have provided support for an association between SNCA and craving for alcohol. METHODS: To examine the role of this gene in alcohol dependence and related phenotypes, 30 single nucleotide polymorphisms (SNPs) were genotyped across the SNCA gene in a sample of 219 multiplex alcoholic families of European American descent. Two phenotypes, alcohol dependence and alcohol craving, were analyzed using the pedigree disequilibrium test. RESULTS: There was no evidence of association between any of the SNCA SNPs and alcohol dependence (p>or=0.13). In contrast, 8 SNPs provided evidence of association (p<0.05) with the phenotype of alcohol craving. Haplotype analysis further supported evidence of an association with alcohol craving; a haplotype encompassing SNPs in intron 4 through the region downstream of the gene was overtransmitted to cravers and a second haplotype was overtransmitted to noncravers. CONCLUSIONS: These results suggest that variation in SNCA contributes to alcohol craving, a common, although not uniform, feature of alcohol dependence.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Bitter and Sweet Diets Alter Taste Response and Alcohol Consumption Behavior in Mice. | Koh AP et al. | β | 2025 | β |
| Aberrant brain topological organization and granger causality connectivity in Parkinson's disease with impulse control disorders. | Gan C et al. | β | 2024 | β |
| Current trends in the role of neuroinflammation & Ξ±-synuclein in alcohol use disorder: A systematic quantitative literature review. | James BC et al. | β | 2024 | β |
| Prenatal alcohol exposure is associated with changes in placental gene co-expression networks. | Deyssenroth MA et al. | β | 2024 | β |
| The Impact of Alcohol-Induced Epigenetic Modifications in the Treatment of Alcohol use Disorders. | Fanfarillo F et al. | β | 2024 | β |
| Network analysis of internet addiction and sleep disturbance symptoms. | Lu JX et al. | β | 2023 | β |
| The collaborative study on the genetics of alcoholism: Genetics. | Johnson EC et al. | β | 2023 | β |
| Sex-Related Differences in Voluntary Alcohol Intake and mRNA Coding for Synucleins in the Brain of Adult Rats Prenatally Exposed to Alcohol. | Kokhan VS et al. | β | 2022 | β |
| Dimensions of Craving Interact with <i>COMT</i> Genotype to Predict Relapse in Individuals with Alcohol Use Disorder Six Months after Treatment. | Padula CB et al. | β | 2021 | β |
| Alcohol Use Disorder, Neurodegeneration, Alzheimer's and Parkinson's Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity. | Kamal H et al. | β | 2020 | β |
| Alpha sinuclein expression in blood and its relationship with chronic constipation in a population from BogotΓ‘, D.C., with problems of alcohol consumption | MartΓnez-RodrΓguez TY et al. | β | 2020 | β |
| Alpha-Synuclein in Alcohol Use Disorder, Connections with Parkinson's Disease and Potential Therapeutic Role of 5' Untranslated Region-Directed Small Molecules. | Cahill CM et al. | β | 2020 | β |
| Epigenetic changes on rat chromosome 4 contribute to disparate alcohol drinking behavior in alcohol-preferring and -nonpreferring rats. | Spence JP et al. | β | 2020 | β |
| The etiology of DSM-5 alcohol use disorder: Evidence of shared and non-shared additive genetic effects. | Palmer RHC et al. | β | 2019 | β |
| DNA methylation signatures: Biomarkers of drug and alcohol abuse. | Mahna D et al. | β | 2018 | β |
| Ethanol (EtOH)-Related Behaviors in Ξ±-Synuclein Mutant Mice and Association of SNCA SNPs with Anxiety in EtOH-Dependent Patients. | Persyn W et al. | β | 2018 | β |
| Emerging Role of Epigenetic Mechanisms in Alcohol Addiction. | Berkel TD et al. | β | 2017 | β |
| Enhanced motivation to alcohol in transgenic mice expressing human Ξ±-synuclein. | Rotermund C et al. | β | 2017 | β |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | β | 2016 | β |
| Epigenetic Modifications, Alcoholic Brain and Potential Drug Targets. | Jangra A et al. | β | 2016 | β |
| An Ξ±-synuclein gene (SNCA) polymorphism moderates the association of PTSD symptomatology with hazardous alcohol use, but not with aggression-related measures. | Guillot CR et al. | β | 2015 | β |
| Nosologic Comparisons of DSM-IV and DSM-5 Alcohol and Drug Use Disorders: Results From the National Epidemiologic Survey on Alcohol and Related Conditions-III. | Goldstein RB et al. | β | 2015 | β |
| Alpha-synuclein deletion decreases motor impulsivity but does not affect risky decision making in a mouse Gambling Task. | PeΓ±a-Oliver Y et al. | β | 2014 | β |
| Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression. | McClintick JN et al. | β | 2014 | β |
| Evidence of a role for SNCA in impulse control in humans. | Guillot CR et al. | β | 2014 | β |
| Genetic risk prediction and neurobiological understanding of alcoholism. | Levey DF et al. | β | 2014 | β |
| Genetics of alcoholism. | Iyer-Eimerbrink PA et al. | β | 2014 | β |
| Genetics of alcoholism. | Edenberg HJ et al. | β | 2014 | β |
| Reduced expression of Ξ±-synuclein in alcoholic brain: influence of SNCA-Rep1 genotype. | Janeczek P et al. | β | 2014 | β |
| A spontaneous deletion of Ξ±-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption. | LΓ³pez-JimΓ©nez A et al. | β | 2013 | β |
| DSM-5 criteria for substance use disorders: recommendations and rationale. | Hasin DS et al. | β | 2013 | β |
| Genetically selected alcohol preferring rats to model human alcoholism. | Ciccocioppo R | β | 2013 | β |
| Genetic influences on craving for alcohol. | Agrawal A et al. | β | 2013 | β |
| Genetic variation in the alpha synuclein gene (SNCA) is associated with BOLD response to alcohol cues. | Wilcox CE et al. | β | 2013 | β |
| NCK2 is significantly associated with opiates addiction in African-origin men. | Liu Z et al. | β | 2013 | β |
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | McClintick JN et al. | β | 2013 | β |
| Substance use disorders: a theory-driven approach to the integration of genetics and neuroimaging. | Karoly HC et al. | β | 2013 | β |
| The role of Ξ±-synuclein in the pathophysiology of alcoholism. | Janeczek P et al. | β | 2013 | β |
| Validity of proposed DSM-5 diagnostic criteria for nicotine use disorder: results from 734 Israeli lifetime smokers. | Shmulewitz D et al. | β | 2013 | β |
| Alpha-synuclein and heroin craving in opiate-dependent patients on injectable heroin maintenance. | DΓΌrsteler-MacFarland KM et al. | β | 2012 | β |
| Human laboratory paradigms in alcohol research. | Plebani JG et al. | β | 2012 | β |
| Large scale association analysis for drug addiction: results from SNP to gene. | Guo X et al. | β | 2012 | β |
| Understanding Alcoholism Through microRNA Signatures in Brains of Human Alcoholics. | Nunez YO et al. | β | 2012 | β |
| Alcohol craving and the dimensionality of alcohol disorders. | Keyes KM et al. | β | 2011 | β |
| Alcohol research: past, present, and future. | Gunzerath L et al. | β | 2011 | β |
| Biochemical and morphological consequences of human Ξ±-synuclein expression in a mouse Ξ±-synuclein null background. | Prasad K et al. | β | 2011 | β |
| Drug-dependent inpatients reporting continuous absence of spontaneous drug craving for the main substance throughout detoxification treatment. | De Los Cobos JP et al. | β | 2011 | β |
| Measures of current alcohol consumption and problems: two independent twin studies suggest a complex genetic architecture. | Dick DM et al. | β | 2011 | β |
| NACP-Rep1 relates to Beck Depression Inventory scores in healthy humans. | Lenz B et al. | β | 2011 | β |
| Nicotine dependence, abuse and craving: dimensionality in an Israeli sample. | Shmulewitz D et al. | β | 2011 | β |
| A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models. | Ehlers CL et al. | β | 2010 | β |
| A principal components analysis of the abbreviated Desires for Alcohol Questionnaire (DAQ). | Kramer JR et al. | β | 2010 | β |
| A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. | Kalsi G et al. | β | 2010 | β |
| Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats. | Liang T et al. | β | 2010 | β |
| Identification of genes influencing skeletal phenotypes in congenic P/NP rats. | Alam I et al. | β | 2010 | β |
| Alpha-synuclein, alcohol use disorders, and Parkinson disease: a case-control study. | Brighina L et al. | β | 2009 | β |
| From QTL to candidate gene: a genetic approach to alcoholism research. | Spence JP et al. | β | 2009 | β |
| Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving. | Hillemacher T et al. | β | 2009 | β |
| Alpha synuclein protein levels are increased in serum from recently abstinent cocaine abusers. | Mash DC et al. | β | 2008 | β |
| Emerging role of epigenetics in the actions of alcohol. | Shukla SD et al. | β | 2008 | β |
| Genetic approaches to addiction: genes and alcohol. | Ducci F et al. | β | 2008 | β |
| High level of alpha-synuclein mRNA in peripheral lymphocytes of patients with alcohol dependence syndrome. | Taraskina AE et al. | β | 2008 | β |
| Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. | Le-Niculescu H et al. | β | 2008 | β |
| Review. Neurogenetic studies of alcohol addiction. | Crabbe JC | β | 2008 | β |
| The tachykinin receptor 3 is associated with alcohol and cocaine dependence. | Foroud T et al. | β | 2008 | β |